LOCUS NC_013315:11 18882 bp DNA linear BCT 07-SEP-2013 DEFINITION Clostridium difficile CD196 chromosome, complete genome. ACCESSION NC_013315 SOURCE Clostridium difficile CD196 chromosome, complete genome. COMMENT locus start: 2232339; locus end: 2251220 COMMENT n1_4mer:GRV/n1_4mer:RV = 3.095113; n0_4mer:D = 19.357977; n0_4mer:PS = 32.351687 FEATURES Location/Qualifiers source 1..18882 /organism="Clostridium difficile CD196 chromosome, complete genome." gene complement(1..1359) /gene="pbuX" /locus_tag="pbuX" /db_xref="2232339..2233697" CDS complement(1..1359) /gene="pbuX" /product="xanthine permease" /translation="MKAKSTSKFELDGIPPLKEAIPLGLQHLMAMVIGSCLPAILIAN ASGLNHKMSTLLIQAALVFAGLSTLLQLYPIPLFKGFKLGGGIPVIMGATAMFIGAGV SVASKYGLPVLFGSQIIAGIVIIIIGFGLKKIRFIFTPAVSGTIVACMGLGLFPIAIK NLAGGMGNETFGNPINFIVGISVSLMILGLNKYGKGLFKDASILVSIIFGYILSLILG IVNFSSIQEFTLVALPKPLAFGLDIRLEVVVMFSIIYLVEIADIMGACTLSAVGGLNR QVTDEELSSAVLGNGVLSTIGALFSATPMGMFGQNSAIVSNTKVVSKFVLAIGGIGLF LAGISPLLANLIRTIPPCVVGGATLVIFSTLTTSGLRLVSMDGFNQENSMILGLSMAS GIGFMVAPQVLEKFPKFIETLLADSSVVSGAMVAIIIQALYMVKFPGNKSDKVEDKNK SL" gene complement(2706..3797) /gene="" /locus_tag="" /db_xref="2235044..2236135" CDS complement(2706..3797) /gene="" /product="hypothetical protein" /translation="MVMQVQEKILELLYTINEDVVSIKNDMSEVKQEMTVMKEDISEV KQEMTVMKEDMSEVKQEINVLKGDMSEVKQEMTVMKEDMSEVKQEINVLKEDMSEVKQ EMIVMKEDMSEVKQEMTVMKEDMSEVKQEMTVMKEDMSEVRQEINIMKEDISEVRQEM TVMKEDMSEVKQEINVLKEDMSEVRQEINIMKEDMSEVRQEMTVMKEDTSEVKQEINV MKKDMSEVRQEITVMKEDVSEVKSEVNFMQNKINNINEDMNGIKDEVSIANEKLYGIE IKIDSLECEDKSMKEIQIEQNNILGSLLHNSEINKATHDNIEHNIAYIKGDTNSIKED IAEIRRDLNLVELATSKNWSDIVKLKSVK" gene complement(4027..5112) /gene="pyrD" /locus_tag="pyrD" /db_xref="2236365..2237450" CDS complement(4027..5112) /gene="pyrD" /product="dihydroorotate dehydrogenase, catalytic subunit" /translation="MYNFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTIR KERAINPAPHMVRNTANALLNNEKWTDFEPEQWIDFEIPQMKRDGTVCIASVGHTIEE SSELVEKVANAGADFIELVSYDYRDLIPMLKDAKERVNIPVIVKLPPMIDEIGDFAKK LEEAGADAITACDSVGPAFRIDIETGQPLLGGNGIGYLSGETIKPITLQRIYEIKKQV NIPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDLKSNLNRLGYN TIENACGIVHNHMGDVNERLSFEFTYDEEKCTKCKMCERVCAYQARKLNDKMELNEEE CRYCGLCISVCKPKALGRKISCSELNV" gene complement(5148..6461) /gene="" /locus_tag="" /db_xref="2237486..2238799" CDS complement(5148..6461) /gene="" /product="amidohydrolase" /translation="MIAIKSKYLISSADEIYTNSAAVVENDIIKDILPNEEVEIKYKN IEEIIDKSDAIIMPGFVNGHMHQYGVLSRGIPANVHFTDFEGFLNDYWWPFIENRIGL KEVKATTKASAIELIESGVVAFCDTLEAPNTEEGTLIEQGKILEEIGMKAILSLESCE RISFENGLRCLDENSNLIKWSRENSKLINGIMCTHTSFTCSDRFIKKAKEDAKKLNAP MQFHLCESIYEPNYAEKHFGKKAVDYYNDLDILDETVLASQCVKVNDEEIDILKEKGV KVVHMPLSNCEVGGGFSPVPKMIKKGIKVALGTDGYINDFFEVMRGAFLMHKSVEEDA SVMPANLVFRMATEHGAYVLGLQNSGKIAVGNKADIIVMEDEFKTPVTLDNIFDQIVV QGKKEFISNVYIDGRHILKEKQLVDLDKKAIVKEMKEVACEFWKF" gene complement(6462..8753) /gene="xdhA2" /locus_tag="xdhA2" /db_xref="2238800..2241091" CDS complement(6462..8753) /gene="xdhA2" /product="xanthine dehydrogenase, molybdenum binding subunit" /translation="MVNKEVRKIDSEAIVTGKPIYTEDLIFHKDVLTIKLLRSPHAFA KIKNIDTKNALKVKGVVNIFTYKDVPNYRYSMVGESYPEASPHDQLILEDVVRYVGDE VAIIAAEDERAAIKAMKLIKVEYEVMTPILDARESEGNKILIHEEDDLFCPFDFGLDA TKNIVSREKMGKGDVEKEFKESDVIVEHSYMTQSQAHCMMETHRAYTYIDTNGRLVVT SANQSAYHMRRQVSKALGIPLSKVRVIKPRIGGGFGGKNIAVTEIYASFVTWMTKRPA KLIYTREETFAMTNTRHQMFFDIKIGADKEGNIKAIDMKALNNTGAYGDNGPSVCSES GHNVLPTYNNVPAIKFDGRTVYTNLVPGGALRGYGATQGTFALDCAIDELAHKLNMDP TEIKLKNIIKKQTEGGIMNFPIRSCALDECIIRGKKLIGWDEKYPVRDIGNNKVRAVG MSVGTHGSGIANIDMAIVNMRMDEDGTYKLFSGSSDLGTGSDTILAQIAAKALNTSID RISVYTGDTDMCPYDTGAYASCTTYVTGNATIKSAESLKQKILKVAQKKLDLPIDDLI LYEDRVCYSEDVEKFVLLSELGKESVGGGNQEVLYSSESYGIQESAKPFLAGFAEIEL DKTTGEFKVINYACSTDCGTVMNPALARIQVEGGVTQGIGLAMYEDPRHGSDGKLQTS NLLQYKVPTKKDIGNIIVDFVDNYEPTGPYGAKSLGEIVIHTPAPAIANAIYNATGVR IRELPITSEKVYMAMKKLNQGGK" gene complement(8743..9567) /gene="pucC2" /locus_tag="pucC2" /db_xref="2241081..2241905" CDS complement(8743..9567) /gene="pucC2" /product="FAD-binding subunit of xanthine dehydrogenase" /translation="VKIKLIWGESMITIKEYVVPKSLDEAYELLISRKNNIILGGCGF LKLGSKNIGSAIDLKDLALDYINETDDSILIGADTSLRTLELNKVIKNYCNGVISNAV SNIVGVQFRSGARVGASVFAKYGFSDLIPSLLVVDAKVKLYKKGVMNLADFLESELEK DILIEVILPKKDAIGVFDSIRKCTGDFAVLNGAMLKEGSIYKIAIGARPRRAKIAYKA SEILSLENDIEKAGEVSSEELSFGSNIRGSKEYRKDMAKALVVRMYNSIGGECDGK" gene complement(9576..10043) /gene="xdhC" /locus_tag="xdhC" /db_xref="2241914..2242381" CDS complement(9576..10043) /gene="xdhC" /product="xanthine dehydrogenase iron-sulfur binding subunit" /translation="MSFEVIYLIIKCTINNKEKELSIRPDDFLADTLRENGYVSVKKG CDTGSCGLCTVMVNDKAVLSCNYLTARVDGQHITTLEGVLDEAKKFGDFLADEGADQC GFCAPGFIMMVLAMKRELQNPTEEEVIDYVNGNLCRCTGYKGQLRAIHKYLNT" gene complement(10094..11518) /gene="" /locus_tag="" /db_xref="2242432..2243856" CDS complement(10094..11518) /gene="" /product="amidohydrolase" /translation="MRGEIRMMDILIKNAIIVTVNKEREVIFDGALVVKDNKIADIGN SKEIESKYTDVKKIIDAKGKVLFPGFINTHNHLFQTLLKGLGDDMVLKDWLETMTFPA ANYLEPKDTYDAAMLGCIEGLRSGITTMVDYMYPHSKPGLCDGIIDAYKELGIRGILG RGCMNTGAQFGVHPGIMQDVETVEKDVRRLFEKHHNTENGRIKIGVAPAAIWSNSQEM LEMLWRVVKEYDDALFTVHISETPFDREAAKELHGQYDIDVLEKLGILGPNVLMVHCV YLTEKDMELTKKYDMKVSHNTASNMYLSSGVAPVPEMLKKGITVSLGVDGAASNNSQD MLELMKLTALQHKVNKCDPLAMSAEKVLELATIDGARAIGMEDEIGSLEIGKKADLLI FNPMLSPKAIPMHNPVSTLVYSSSMKNIESVIVDGNIIMEDSKILTANEEKALKDAQD TAERLCVRGTIKNRMEGHKWNSLY" gene complement(11518..12888) /gene="" /locus_tag="" /db_xref="2243856..2245226" CDS complement(11518..12888) /gene="" /product="D-hydantoinase" /translation="MGTILRGGTIITSDKTYISDLRIEDEKIVEIGNNLEINGDKVID ATGKIVIPGGIDTHTHFDMNAGSITTADNFETGTRAAIAGGTTTILDFAEANEGENLL QGVEAYHKKASGNCYCDYGFHMTITCLNKDTFNHMEKLISDGIVSFKMYMAYDGMKVD DGTIYRVLKKARDLGCIVGFHCENGDLLDVLIEENIQNGNLEPKYHPLTRPNIVEKES VSRLADITKLSNSKSYVVHLSCRESLETVKMAREKNIDMIVETCPQYLLLEDNLYNKN KFEGAKYVMSPPLRKKEDINYLWEGLSSGDIQTVGTDHCSFNFKGQKDLGIDDFSKIP NGAPGVEHRLALLYTYGVLENRISVNKFVEVTSTNAAKIFGMYPKKGEIAVGSDADIV ILNINKEETISYKTQKQNVDYTPYEGFKVKCKVEDVFLRGNHVVQSCNVKEHPTGQYI KRKITK" gene complement(13021..14208) /gene="" /locus_tag="" /db_xref="2245359..2246546" CDS complement(13021..14208) /gene="" /product="peptidase" /translation="MLNEQRKQEVTEICQKLIQNPSSSGNEEGVVKAIEESFEKLGFD SWSRDRYGNIVGCIKGNKPGKKILFDGHIDTVPVPDASKWSVPPFEGKIVDGKIYGRG TSDMKGQYTAMMSAVAYFAKDTNRDFAGELYVAGVVHEEIFEGVSAREISKAVQPDYV VIGESSELNLKIGQRGRGEIVVETFGKPAHSANPEKGVNAVYKMANVIQKIQQLVPPT HPVLGDGILVLTDIKSSPYPGASVVPDYCKATFDRRLLVGETREGVLAPIQALLDEMM KEDPELNAKVSYAVEKADCYTGNTIESERFFPGWLYDEEDEFVQAAYKGLKEAGIDSE ITQYSFCTNGSHYAGEAGIKTIGFGPSKENLAHTIDEYIEQEQLFIGTEGYYGILKSV YGK" gene complement(14335..15549) /gene="dpaL1" /locus_tag="dpaL1" /db_xref="2246673..2247887" CDS complement(14335..15549) /gene="dpaL1" /product="diaminopropionate ammonia-lyase" /translation="MLKEIKWKVNNLPKGDKENCIKFLNEEEITKVRNFHKSFPQYKE TPLANLEGLAKKLGVAGVYVKDESYRFGLNAFKVLGGSYSMGRYLAQRLDTDISELGY DKLTSKEIKEKLGEITFFTATDGNHGRGVAWTANKLGQKSVVLMPKGSSEFRLNKIKG EGADASITDLNYDDAVRLANDYAEADDHGVMVQDTAWDGYEEIPAWIMQGYGTMAQEA IEQLKEYGVDRPTHVFVQAGVGSLAGAVQGYVASIYDECPITVVVEADEADCYYKSAE AGDGKPRFVGGDMPTIMAGLACGEPNTIGFEVLKNHAAAFVSAPDWVSAKGMRTLGNP LNGDEKVISGESGAVTTGLLVAAMEREDLADLRKDLKLDENSRILLISTEGDTDPDKY RSIVWDGEYPSI" gene complement(15912..16583) /gene="" /locus_tag="" /db_xref="2248250..2248921" CDS complement(15912..16583) /gene="" /product="iron-sulfur flavoprotein" /translation="MAKILGICGSPRKGATEYAVLEALKEAETIPGIETEYWSVRGKK ISPCVHCDACIRKETMCIIKDDIQELEQKILEADGIIVGSPVYDMNITAQLTAVFNRL RPMYLVHPGKLQNKVGAAITTGGTRYGGQELTKLPIINFFLMHEMLVSGGLGGCYIGG TIWSKDGKAKGAQEDETGMDTVKRLGKGAAEAVMVSKFGLEKWNVVKEELDVKKDEKS PLRDH" gene complement(16666..18882) /gene="" /locus_tag="" /db_xref="2249004..2251220" CDS complement(16666..18882) /gene="" /product="xanthine dehydrogenase" /translation="MEKVIGKSYPLKDAALKVTGQMKYVADMKPQNVLYAKMLLSPVA HAKIKSIDTSEAEKVVGVRAIATYLNTSQRKYNGSLRFYEHNIPENEVIFSDTVRFVG DRVAAVAAETPEIAEKAVKLIKVEYEELPAVFTIQDAIKEDAICIHGDSNIVSQNNIN GGDVEKGFKECDYIFEDEYSTPAIHHSAIETHSVIAHYDYNDKLTVHTPCQNTFGFRI ILSQIFGMSLNKVRVIRPAIGGSFGGKLELTIEPVAAALSKMTRRPVKMVLTRKESMI STRTRHGSFVKLKTGVNKDGEVIAQDIKIYTNTGAYASSALNVIGALSHKVFKVYKIP NIKFTGMPVYTNTPIAGAMRGYGSPQIFMAQQAQFAKIAKEIGMDLVDFQNKNAVEPD DVDIIFRGSLGNPRVLDCIEQGKKMFKWDEKKKLPKEEGKYLRGIGMAIGAHGNGVFG AHRDVVTLTLKLNEDGTLTLLTGAHDMGNGVVTMQTMMVAEVLGITPDKVDTFETDTD ACTFNLGDYASRGVFVEGGGAKKTAEKLKNLIVEEAEKLLETSKEDLYLDNGYVISKL DENVKASLSDVAVYSQSKSLRELTVVEDYSSPAGLTSYGVHFAEVLVDKETKDIKVVD FVAVHDVGRVINPLNLEGQLEGGIHMGLGYALSEELAFDEQGRPKATDFKTYKLFRTV DMPKCQVAFVNSYEKAGPFGGKSIGECAVVPVAPAVANAVYNATDVEIHSLPIKLK" ORIGIN 1 ttataaactt ttatttttat cctcaacctt atcactttta tttccaggaa attttaccat 61 atataaagct tgaattatta tggctaccat tgctcctgaa actacacttg aatctgcaag 121 taatgtctct ataaattttg gaaatttttc aagaacttga ggagctacca tgaatccaat 181 accagaagcc atagaaagac ctaatatcat gctattttct tgattaaatc catccatact 241 aacaagtctt aaaccagatg ttgtaagagt tgaaaatata acgagtgttg ctcctccaac 301 cacacaggga ggaattgttc ttattaaatt agctaataaa ggcgatattc ctgccaaaaa 361 taatccaatt cctccaatag ctagtacaaa tttacttaca acctttgtat tggaaacgat 421 tgcagaattt tgtccaaaca tccccattgg agttgcagaa aataatgcac ctattgtaga 481 gagtactcca tttcctaaaa cagcagaaga aagttcttca tctgttactt gtctattaag 541 ccctcctacc gcagaaagtg tacaagcacc cattatatca gctatctcaa ctaaatatat 601 tattgaaaac attacaacaa cttcaagtct tatatctagc ccaaaagcaa gtggttttgg 661 aagcgcaacc aaagtaaact cctgaattga agaaaaattt actataccca aaattaatga 721 taaaatgtat ccaaaaatta tgctaactaa tattgatgca tctttaaata atccttttcc 781 atacttattt aatcctaata tcataagaga tacagatatt ccaactataa aattaattgg 841 attcccaaaa gtctcattgc ccataccccc agctaagttt tttatagcta ttggaaaaag 901 tccaagaccc atacatgcaa ctattgttcc tgatacagct ggagtaaata taaatcgtat 961 ttttttaaga ccaaaaccaa ttataattat tactatacca gctattattt gagagccaaa 1021 taatactggt agtccatact tacttgcaac agatacccca gctcctataa acatagctgt 1081 agctcccatt ataactggta ttcctcctcc taatttaaaa cctttaaaca aaggtattgg 1141 atataattgt aataaagttg ataatcctgc aaaaactaat gcggcttgaa tcaataatgt 1201 tgacatctta tgattaagtc cagatgcatt tgcaatcaat atcgctggta aacaactacc 1261 tattaccatt gccattaagt gttgtaaccc taaaggtatt gcttccttta gtggtggtat 1321 tccgtctaat tcaaattttg atgtactttt tgctttcata ataaaaactc ccgttacata 1381 aaacttattg aattatataa atacttaaaa atctaatata ttaaattaat gatgttcata 1441 aatatcaact atactccaac atatatttaa gtttttagtc ttaaaaaaca gatgcaataa 1501 atttaattat taacaaatac acgtattctt taattttgta tacattatat accatgcttt 1561 acaaatataa gagtattata gctatgaatt tttaattttt tatagtaaat ttaattcaat 1621 ttaaatcttt caatcttaat cattataagt tataagtttt cataagtatt tacatgtttc 1681 aagttttaaa catttaccta taaacgctac tttatagatg tcacttcaaa tctagtgacc 1741 tcatactttc atatgagcgt agactatttc ttcatcttca gcattacctg ctaagagcaa 1801 cccgtttcca ctatcaatcg cttatagtgt actctctctc gagatagtcg tttgaccttc 1861 ctatttctag gcttggcgac caaatgtcca tttttaagta cttaggctct caccatatac 1921 catcctcact attgtttctg gttttcacca cattcataaa agtttctttc tatcttttat 1981 tgtagttgca aggctttagg atttactggt tttaaagttg tgtcctacat agatttctct 2041 atgtacgggg ccaaaagtac aatttattta acatactttg ctttaccccc tgtaaataat 2101 attatttact ctttcactgt ttttgttatt aaattaatta aatatcaatt aatctaagca 2161 taaaataatt atttaattta aactcaaaat atttatgaat attttataat ataattctca 2221 taagacagaa aaacttaata agctatgtat ctcagttgta ccaatgtact ctcctttact 2281 atatttgtat ctgcaacata aaatatacaa gtttctatct atttatagat atatatatct 2341 ataagcaaaa tagtaatatt atttttatag taaaaatttt attcatatta ctatttataa 2401 tttttataga gcaattttag tgccaatatt tgcatacatt tgtatagtat aaaattttta 2461 tgttctcatt gataaaattt tacttatttc aagcgtttta ttcgatttta tcatctaaat 2521 tttaggtttt atttttataa attaattgta tttacataaa aaaaaagacc taaaaacaaa 2581 tttttaacgg tcttttctca attttttatt ttcatttcta aaatttataa taaatagtaa 2641 gaacactata aattctttta tataaaattc ttagtttgtg gatgataaat tagtgaatta 2701 aaatactact ttactgattt tagtttgaca atatcactcc aatttttact agtggctaac 2761 tctactaaat ttaagtctct tcttatttca gctatatcct cttttataga attagtgtca 2821 ccttttatat atgctatgtt atgttctata ttatcatgag tagctttatt tatttcagaa 2881 ttatgtaata aacttcctaa aatattattc tgttctatct gtatctcttt cattgattta 2941 tcttcacatt ctagactatc aatcttaatt tcaattccat ataatttttc atttgctatg 3001 gatacctcgt ccttaattcc attcatatct tcattaatgt tatttatttt attttgcata 3061 aagtttactt ctgatttaac ttcggaaaca tcttctttca ttacagttat ttcttgtctt 3121 acttctgaca tgtctttttt cattacattt atctcttgtt ttacctctga tgtatcttct 3181 ttcattacag tcatttcttg tcttacttca gacatatctt ctttcattat atttatctct 3241 tgtcttactt cggacatatc ttcttttaat acatttatct cctgttttac ttccgacata 3301 tcttctttca ttacagtcat ttcttgtctt acttcggata tatcctcttt cattatattt 3361 atctcttgtc ttacctctga catatcttct ttcattacag tcatttcctg ttttacttcc 3421 gacatatctt ctttcattac agtcatttcc tgttttactt ccgacatatc ttctttcatt 3481 acaatcattt cctgttttac ttccgacata tcttctttta atacatttat ttcctgtttt 3541 acttccgaca tatcttcttt cattacagtc atttcttgtt ttacttccga catatctcct 3601 tttaatacat ttatctcctg ttttacttcc gacatatctt ctttcattac agtcatttct 3661 tgttttactt ctgatatatc ttctttcatt acagtcattt cttgttttac ttccgacata 3721 tcatttttta tgctaactac atcttcattt atagtatata ataactctaa aatcttctct 3781 tgcacttgca tcaccatccc tattaattat tataacattt tacacaaatg ctatacaatg 3841 ttaacatata tatcagaatt attaaaattt taattaaaca aaattgattc actttattac 3901 ttcaaaacta attaatatct aaaataacta caaataaaca aaaataaggt caacaacaaa 3961 aaaggcttat ctctttgaga tagcctttct tatttttatt taaaactttg ttttttataa 4021 aataatctat acattcagct ctgaacatga aatttttctt ccaagtgctt ttggtttaca 4081 aactgatata caaagtccac aatatctaca ctcttcttca ttcaattcca tcttatcatt 4141 caattttctc gcttgatatg cacaaactct ctcgcacatc ttacatttag tacatttttc 4201 ttcatcataa gtaaactcaa agctaagtct ttcattaaca tctcccatat gattatgtac 4261 tataccacaa gcattttcta tagtattata tcctaatcta ttaagattag attttaaatc 4321 atcatgtatt ttagatatta cttgtgcgcc ttttaaaatt actactgaac atataccaac 4381 aaagtcagca cctgccataa tcatttctaa ggcatcatct ccacttacac atccacctaa 4441 gccaattatt ggtatattaa cttgtttttt tatttcatat attctctgta aagttattgg 4501 cttaatagtt tctccactta aatatcctat tccatttcca cctaataaag gttgccctgt 4561 ttctatgtct attctaaatg ctggtcctac agagtcacaa gcagttattg catctgctcc 4621 tgcttcttct aattttttag caaaatcgcc tatctcatct atcataggag gaagtttaac 4681 tattacaggt atatttactc tttcctttgc atctttaagc attggtatca aatctctata 4741 gtcataagat actaattcaa taaagtcagc tcctgcattt gcaactttct ctactaattc 4801 gctactttct tcaattgtat gacctactga agctatacag acagtcccat ctcttttcat 4861 ttgtggtatt tcaaaatcta tccattgctc tggctcaaaa tctgtccatt tttcattatt 4921 taaaagagca ttagctgtat ttctaaccat atgtggtgct ggatttatag ctctttcttt 4981 tcttatagtc ttagtcacaa ctgcccctgc tcctgcatca cttaatatct tgcatccagc 5041 tgcactatat gttaatggtc ctgaacctat tataagtggt gattttaatt ctttacctaa 5101 aaaattatac attatctgct tccccttttc atatatattt acattcgtta aaatttccaa 5161 aattcacaag caacttcttt catttcttta acaatagctt ttttatctaa atcaactaac 5221 tgtttttctt ttaaaatatg tctaccatct atgtatacat ttgatataaa ttctttttta 5281 ccctgaacta ctatctggtc aaatatatta tcaagagtca caggagtttt aaattcatct 5341 tccataacta ttatatcagc cttattacca actgctattt taccagaatt ttgaagtcct 5401 aatacataag caccatgctc tgttgccatc ctaaatacta aatttgctgg cattactgat 5461 gcatcttctt caactgattt atgcattaaa aatgcacctc tcataacttc aaaaaaatca 5521 tttatatatc catcagtacc cagtgccact tttatgcctt ttttaatcat ttttggtact 5581 ggagaaaaac ctccacctac ttcacagttg ctaagaggca tatgaaccac ttttacacct 5641 ttttctttta atatatctat ttcttcatca tttactttta cacactgaga tgctaataca 5701 gtttcatcca atatatctaa atcattatag tagtcaactg cttttttgcc aaaatgtttt 5761 tcagcatagt ttggctcata tatactctca cataaatgaa attgcattgg tgcatttaat 5821 ttttttgcat cttctttagc tttcttaata aatctatcag aacatgtgaa gcttgtatgt 5881 gtacacatta ttccatttat taatttacta ttttctctac tccactttat taaattagaa 5941 ttttcatcta aacatctaag tccattttca aagcttattc tttcacaact ttctaaggat 6001 aaaatcgctt tcatgcctat ttcttctagt atttttcctt gctcaattaa agttccttct 6061 tctgtatttg gagcttctag ggtatcacaa aaagctacca caccagattc tataagttct 6121 attgctgatg ctttagttgt tgccttcact tctttcaatc caattctatt ttctataaat 6181 ggccaccaat agtcatttaa aaaaccttca aagtcagtaa aatgtacatt tgccggtatt 6241 cccctagaaa gaactccata ttgatgcata tgaccattga cgaatcctgg cattattata 6301 gcatctgatt tatctattat ttcttcaata tttttatatt ttatttcaac ttcttcattt 6361 ggcaatatat cttttataat gtcattttct actacagcag cagaatttgt atatatttca 6421 tcagcagaag atattaagta tttactttta atagcaatca tttatttacc tccctgattt 6481 aattttttca tggccatata aactttctca gaagttatag gaagttctct tatacgaact 6541 cctgtggcat tgtatattgc atttgctatt gctggtgcag gtgtatgaat aactatttct 6601 cctaaagatt tagctccata tggacctgtt ggctcataat tatctacaaa atcaacaatt 6661 atgtttccta tatctttttt tgttggaact ttgtattgta atagattaga agtttgaagc 6721 tttccatcag aaccatgtct agggtcttca tacattgcaa gccctatacc ttgagttaca 6781 ccaccttcaa cttgtattct agcaagtgca ggattcataa ctgtaccaca atctgtagaa 6841 caagcataat ttattacttt aaactcccct gttgttttat ctaactctat ttcagcaaat 6901 cctgctaaga atggtttagc actctcttgt ataccataag attcagatga atataaaact 6961 tcttgatttc caccaccaac agattctttt cctaattcac ttaacaaaac aaacttctct 7021 acatcttcac tataacaaac tctgtcttca tatagtatta aatcatctat tggtaaatcg 7081 agtttcttct gtgctacttt taatatcttt tgttttaaac tttcagcaga ttttattgta 7141 gcatttccag ttacataagt agtacaagaa gcgtatgcac cagtatcata tggacacata 7201 tctgtatctc ctgtataaac ggaaattcta tcaatagatg tattcaatgc ttttgcagct 7261 atttgtgcaa gtattgtgtc agaaccagtt cctaagtctg aagacccaga aaacaactta 7321 taagttccat cttcatccat cctcatattt actattgcca tgtctatgtt ggctatacca 7381 gaaccatgag ttcccacaga cattccaaca gccctcacct tattgtttcc aatatcccta 7441 acagggtact tttcatccca tccaataagt tttttacctc taattataca ttcatcaagt 7501 gcacaacttc ttattggaaa attcattatt ccgccttcag tttgtttttt tataatattc 7561 tttaacttta tttctgttgg gtccatatta agtttatgcg ctaattcatc aattgcacaa 7621 tcaagtgcaa atgtaccttg tgttgctcca tatcctctta atgctcctcc tggaactaaa 7681 ttagtatata cagttctccc atcaaatttt attgcaggta cattattata tgttggaagt 7741 acattatgac ctgattcaga gcaaactgaa ggtccattat caccataagc gcctgtatta 7801 ttcaatgctt tcatatctat agcttttatg tttccttctt tatctgcccc aatttttata 7861 tcaaaaaaca tctgatgtct agtattagtc attgcaaaag tttcttctct agtataaatt 7921 agttttgctg gtctttttgt catccaagtt acaaatgatg catatatctc tgttacagct 7981 atgttttttc caccaaaacc tccacctatt cttggtttta ttactctaac ttttgaaaga 8041 ggtattccca gtgctttaga aacctgtctt ctcatatgat aagctgattg gtttgcagaa 8101 gttactacta atctgccatt cgtatctata tacgtataag ctctatgagt ttccatcata 8161 caatgggctt gtgattgagt catataagaa tgttctacta ttacatcact ttctttaaac 8221 tctttttcta catccccttt acccattttt tctctcgata caatattttt tgtagcatcc 8281 aatccaaaat caaatggaca aaacaaatca tcttcttcat ggattaaaat tttatttcct 8341 tccgattctc ttgcatccaa tataggagtc attacttcat attcaacttt tataagtttc 8401 atagctttaa tagcagccct ttcatcttca gcggctatta tagcaacttc atctcctaca 8461 tatctaacta cgtcttcaag tattaattgg tcatgaggtg atgcttctgg atatgactct 8521 ccaaccattg aatatctata atttggaaca tctttgtaag tgaatatgtt tactacacct 8581 tttaccttta atgcattttt tgtatctatg ttttttatct tcgcaaaagc atgcggactt 8641 ctaagaagct taattgttaa aacatcttta tgaaaaatta aatcttctgt atatattggt 8701 tttccagtaa caatggcttc actatctatt tttcttacct ctttatttac catcacactc 8761 acctccaata ctattataca ttctcactac taaggctttt gccatatctt ttctgtattc 8821 tttacttcct cttatattac ttccaaatga aagttcttca cttgatactt caccagcttt 8881 ttctatatca ttttctaaac ttaatatttc acttgcttta taggcaattt ttgctcttct 8941 tggtctagcg cctatcgcaa ttttataaat acttccttct tttaacattg ctccatttaa 9001 tactgcaaaa tcacctgtac attttcttat agaatcaaat acacctatag catctttttt 9061 aggtaatata acttctatta atatatcttt ttcaagctca ctttctaaaa aatcagctaa 9121 gttcataacc ccttttttat ataacttaac ctttgcatct accactagta atgaaggtat 9181 taaatctgaa aatccatact tagcaaatac gctagctcct actctggctc cacttctaaa 9241 ttgaactcct actatattag aaacagcgtt tgaaattacc ccattacagt aatttttaat 9301 aaccttattt aattctaaag ttcttaaact tgtgtctgct ccaattaata tgctatcatc 9361 agtttcattt atataatcta aagctaagtc ttttaaatct attgctgagc caatattttt 9421 actacctagt tttaaaaatc cacatcctcc aagtattatg ttgttttttc ttgatattag 9481 cagttcataa gcttcatcta aactttttgg aactacatat tcctttatag ttatcatact 9541 ctctccccat atcaacttaa ttttcactta aaagtctaag tgtttaaata tttatgtatt 9601 gctcttaatt gacctttata tcctgtacat ctacaaaggt taccatttac ataatctata 9661 acttcttctt ctgttggatt ttgaagctct cttttcattg ccaaaaccat cattataaat 9721 ccaggagcac aaaatccaca ctggtcagcc ccttcgtctg caagaaaatc tccaaacttc 9781 tttgcttcat ccaagacccc ctcaagtgtt gtaatatgct gaccatctac tctagcagta 9841 agataattac atgaaagcac ggccttgtca tttaccatca ctgtacataa cccacatgag 9901 cctgtatcac accctttttt aacacttaca tatccatttt ctcttaatgt atctgctaaa 9961 aaatcatctg gtcttatact taattctttt tctttattat ttatggtaca tttgataatc 10021 aaataaatca cctcaaaact catattttta agctaaagtt ttactatact tttctatgaa 10081 taaattacat ttattaataa aggctattcc atttatgacc ttccattcta ttttttatag 10141 ttcctcttac acaaagtctc tcagctgtat cttgagcatc ttttaatgct ttctcttcat 10201 tagctgtcaa tatttttgaa tcttccatta ttatatttcc atctactata acactctcta 10261 tatttttcat actagaagaa tatactaatg tagataccgg attatgcata ggtatcgctt 10321 ttggtgaaag cattggatta aatattagta agtctgcttt tttacctatc tccaatgaac 10381 ctatctcatc ttccattcca atagctcttg ctccatctat agttgccaac tcaagaactt 10441 tttctgccga cattgctaat gggtcacact tattaacttt atgttgaagt gctgttaatt 10501 tcataagttc aagcatatct tgagagttat tactagcggc tccatctact cctaaactaa 10561 ctgttattcc ttttttaagc atttctggca ctggtgcaac acctgaagat aagtacatat 10621 tacttgctgt attatgagac actttcatat cgtatttttt agtaagttcc atatcttttt 10681 cagttagata cacacaatgt accataagca catttggtcc aagtattcct aatttttcta 10741 aaacatctat gtcatattgc ccatgcaatt cttttgctgc ttctctatca aaaggagtct 10801 ctgatatatg tactgtaaat aaagcatcat catattcttt taccactctc catagcattt 10861 caagcatttc ttgagaattt gaccatattg ctgcaggagc tactcctatt ttgattcttc 10921 cattttctgt attatggtgt ttttcaaaca atcttcttac atctttttca accgtttcta 10981 catcttgcat tattccagga tgaactccaa attgagctcc tgtattcata catcctcttc 11041 caagtattcc tcttattcct aattctttat aagcatctat tattccatca caaagacctg 11101 gcttactatg aggatacatg tagtcaacca tggtcgttat accacttcta agtccttcaa 11161 tacatccaag cattgcagca tcataagtat cttttggctc taaatagtta gctgctggaa 11221 atgtcatagt ttctaaccag tctttaagta ccatatcatc tcccaatcct tttaataaag 11281 tttggaataa atgattatgt gtatttataa aacctgggaa taaaacttta cctttagcat 11341 ctataatttt tttaacatca gtatatttac tttctatctc tttagaattt ccaatatcag 11401 caatcttgtt atcttttact actaatgccc catcaaaaat aacttctctc tctttattca 11461 cagttactat tatggcattc ttaataagta tatccatcat tcttatttcc ccccgcatta 11521 tttagtaatt tttcttttaa tatattgacc tgttggatgt tctttaacat tacaactttg 11581 tactacatga tttcctctca aaaatacatc ttcaacttta catttaacct taaatccttc 11641 atatggagta taatctacat tttgtttttg agttttataa ctaattgttt cttctttatt 11701 gatatttaaa atgactatat ctgcatcact tcctacagct atctcacctt ttttaggata 11761 cattccaaat atttttgcag cattcgtaga agtaacttcc acaaacttat ttacacttat 11821 tctattttct aagaccccat atgtatataa aagtgctaac ctatgttcaa caccaggtgc 11881 tccatttggt atcttactaa aatcatcaat tcccaagtct ttttgcccct taaaattaaa 11941 tgaacagtgg tctgtgccaa ctgtttgaat atctccacta gacaatcctt cccaaaggta 12001 atttatgtct tctttttttc ttaaaggagg agacattaca tacttagcac cctcaaattt 12061 attcttatta tataaattgt cttctaataa tagatactgt gggcatgttt ctactatcat 12121 atctatattt ttttctctag ccatttttac agtttcaagt gactccctac aacttaagtg 12181 gactacatag gattttgaat tagataattt agttatatca gcaagtcttg aaacagactc 12241 tttctcaact atgttaggtc ttgtaagtgg atgatatttt ggctctaaat taccattttg 12301 tatattttct tctatcaata catctagtaa atccccattt tcacaatgaa atccaactat 12361 acaacctaaa tcccttgctt tctttaaaac cctgtatatt gttccatcat ctactttcat 12421 gccatcatat gccatataca tcttaaaaga tactatccca tccgaaataa gtttttccat 12481 atgattaaat gtatctttat ttaaacatgt aattgtcata tgaaaaccat aatcacaata 12541 acaatttcca cttgcttttt tatgatatgc ttctacacct tgcagtaggt tttccccctc 12601 attggcttct gcaaaatcta gtattgtagt agttcctcca gctatagctg ctcttgttcc 12661 tgtttcaaaa ttatctgcag ttgtaataga acctgcattc atatcaaaat gagtatgtgt 12721 gtctattcca ccaggaatta caattttacc tgtagcatca ataaccttat caccatttat 12781 ttctaagtta tttcctattt caactatctt ttcatcttct atccttaaat cacttatata 12841 agtcttatca gaggtaatta tagttccacc tcttagtatt gttcccatat atacctccta 12901 acttttaagc tttaaagtat tttctaagta tcgtaaaact ttatttaaaa ttgtattttc 12961 taaaggtgct atattcagca cctctagact atatttaaat aatttattgt gaactaaata 13021 ttattttccg tatacagatt ttaatattcc atagtaacct tctgttccta taaataactg 13081 ttcttgctct atatactcat ctattgtgtg agcaagattt tccttagaag gaccaaatcc 13141 tatagttttt attccagctt cacctgcata gtgacttcca ttcgtacaga atgagtattg 13201 agttatttct gaatctattc cagcttcttt taatccctta tatgctgctt gaacaaattc 13261 atcttcttcg tcatataacc aacctgggaa gaatctttca ctttctatag tatttcctgt 13321 atagcaatca gctttttcaa ccgcataaga aactttcgca tttaattctg ggtcttcttt 13381 catcatttca tctaataaag cttgtattgg agctaatacg ccttctcttg tttctccaac 13441 taataatctt ctatcaaaag tagctttgca ataatctggc actactgatg cccctggata 13501 tggagaagat tttatatctg ttaaaactaa tattccatca cctaaaactg gatgagttgg 13561 aggtactaat tgttgtatct tttggattac attagccatt ttataaactg catttacacc 13621 tttttctgga ttagcagagt gagctggttt accaaaagtt tctactacta tttctcctct 13681 acctctctga ccaatcttta agtttaactc tgaagactca cctattacaa catagtcagg 13741 ttgaacagcc ttacttatct ctctagccga aacaccttca aatatttctt catgaacaac 13801 acctgctaca tatagttctc cagcaaaatc tcgattagtg tctttagcaa aatacgctac 13861 agcagacatc attgcagtat attgaccttt catgtcagaa gttcctctac catatatctt 13921 tccatcaact atttttcctt caaaaggagg aacactccat ttacttgcat ctggaactgg 13981 aactgtatct atatgtccat caaataatat tttcttacct ggcttgttac cttttataca 14041 tcctactata tttccatatc tatctcttga ccaactatca aaacctaatt tttcaaaaga 14101 ctcttctatt gcttttacaa caccttcttc atttccagaa gaactaggat tttgaattaa 14161 tttttggcat atttcagtta cttcttgttt tctttgttcg tttaacattt cattatcccc 14221 ctagattttt tataatgtat gtattttata tacttatata ttttctaaat tttagaactt 14281 atatatcttc taaatatgta aaccaatatc taataattgc attttagtaa ttccttatat 14341 acttggatat tctccatccc aaactatact tctatatttg tcagggtcag tatctccttc 14401 tgtgcttatt aaaagtattc ttgaattttc atctaatttt aaatcttttc ttaaatctgc 14461 taaatcttct ctttccatag ctgctactaa aagaccagtt gtaactgctc cagattctcc 14521 agaaattacc ttttcatcac catttaaagg attacctaat gttctcatac ctttagcaga 14581 aacccagtct ggtgctgaaa caaatgctgc agcatgattt tttaatactt caaatcctat 14641 agtatttggt tctccacaag caagaccagc cattatagtt ggcatatctc ctccaacaaa 14701 tcttggtttt ccatctcctg cttctgctga tttatagtag caatcagctt catcagcttc 14761 tactactact gttattgggc attcatcgta tattgaagca acatatcctt gaactgctcc 14821 agcaagtgaa ccaacccctg cttgcacaaa tacatgtgtt ggtctatcta ctccatattc 14881 ttttaattgc tctatcgctt cttgagccat agttccatat ccttgcatta tccatgctgg 14941 aatttcttca tatccatccc atgctgtatc ttgaaccatt actccatgat catcagcttc 15001 tgcataatca ttagctaatc ttactgcatc atcatagttt aagtctgtta tactagcatc 15061 tgctccttct cctttaattt tatttaatct aaactcagaa gaaccttttg gcattaatac 15121 aacagatttt tgacctaatt tattagctgt ccaagcaact cctctaccgt gatttccatc 15181 tgtagctgta aagaaagtta tttctcctaa tttttctttt atttctttcg aagttaattt 15241 gtcataccct aactcagata tatctgtatc taatctttga gctaagtatc tacccataga 15301 ataagaacca cctaatactt taaatgcatt taatccaaat ctataagatt catcttttac 15361 atatactcct gcaacaccta atttttttgc taaaccttct aggtttgcta atggagtttc 15421 tttatattga ggaaagcttt tgtgaaaatt tctaacctta gttatttctt cttcatttaa 15481 aaatttgata caattttcct tatcaccctt tggcaaatta tttactttcc atttaatttc 15541 ttttaacatc taaaatacct ccaaattatt gttaaatttt tatactttaa tatataagca 15601 attaacatgc caacactaaa tatatactag atatttttct atgactcttt agtatagaaa 15661 ttgcaatgct tttattattc tttcttttct atctttagtt catacaatgt atgtagaatt 15721 taataactaa aaaacctttt ctatcttctc actttttaat tctcattttt aaaatttaaa 15781 aataaatctc aaaacacttt gtttctatat tttttaatat aaaatttata aaatctaaat 15841 taaaacataa aatagtgatg caataatcta ttacatcact atttgtatat atttaataat 15901 ataataaatc tttagtggtc tctaagaggt gatttttcat cttttttaac atctaattct 15961 tcttttacga cattccattt ttcaagacca aacttagaaa ccataactgc ctctgcagca 16021 ccttttccaa gtctttttac tgtgtccata cctgtctcat cctcttgggc accttttgct 16081 tttccatctt tactccatat tgtaccacct atatagcatc cacctaaacc tccagatact 16141 aacatttcat gcattaggaa gaaatttatt ataggaagtt ttgtcaattc ttggccacca 16201 tatctagttc caccagtagt tatagctgca ccaaccttat tttgaagttt tcctggatga 16261 actaaataca ttggacgaag tctattaaat actgctgtaa gttgagcagt tatattcata 16321 tcataaactg gagaacctac tataattcca tctgcctcca atattttttg ctctaattct 16381 tggatatcat cttttataat acacatagtt tcttttctta tacatgcatc acaatgtaca 16441 caaggactta tttttttccc tctaactgac caatactcag tttctatacc aggtatagtt 16501 tctgcttctt tcaaagcttc taacactgca tattctgttg ctcctttacg tggacttcca 16561 caaataccta atatctttgc cataataata tctcctcacc aaataaatct atttttatta 16621 tctatttaca aatacaataa attgttgttt gtgctttaat ttctactatt ttaattttat 16681 tggcaatgaa tgtatttcta catcagttgc attatatact gcatttgcaa cagctggcgc 16741 aactggtaca acagcacatt ctccaatact cttaccacca aaaggtccag ctttttcata 16801 actatttaca aatgcaactt gacattttgg catatctaca gttctaaata atttatatgt 16861 tttaaaatca gtagctttag gtctaccttg ttcatcaaat gccaattctt cactcaatgc 16921 gtatcctaga cccatatgaa tcccaccttc taattgacct tctaaattta aaggatttat 16981 aactctacca acatcatgta cagctacaaa atcaactact tttatatcct tagtttcttt 17041 atctactaaa acttcagcaa aatgtacacc ataagaagta agtccagctg gtgaagaata 17101 atcttcaaca acagttaact ctcttaatga tttactttga ctatatactg cgacatcaga 17161 aagtgatgct tttacatttt catcaagttt actaattaca tatccattgt ctagatataa 17221 atcttctttt gatgtttcaa gtaatttttc tgcttcttct actataaggt ttttcaattt 17281 ctctgctgtc tttttagctc ctccaccttc tacaaatacc cctctacttg catagtcacc 17341 aaggttgaat gtacatgcat ccgtatcagt ttcaaatgta tcaactttat caggtgttat 17401 tcctaaaact tcagctacca tcattgtttg catagttacg acaccattac ccatatcatg 17461 tgctcctgtt agtagtgtca atgtaccatc ttcatttaat ttaagagtca atgtaacaac 17521 atctctatgt gcaccaaaaa ctccattacc atgtgcacct attgccatac ctatacctct 17581 taaatatttt ccttcttctt ttggaagttt tttcttttca tcccacttaa acatcttctt 17641 accttgctct atacaatcca atactctagg atttccaaga gaaccgcgga agattatatc 17701 gacatcatct ggctctactg catttttatt ttgaaaatcg actaaatcca tacctatttc 17761 cttggctatt ttcgcaaatt gagcctgttg agccataaat atttgaggtg acccatagcc 17821 tctcatagct cctgctattg gtgtatttgt atatacaggc atcccagtaa actttatatt 17881 tggtatttta taaactttaa atactttatg actaagtgct cctataacat ttaaagcact 17941 tgatgcatat gctcctgtat ttgtatatat ttttatatct tgtgctatta cttcaccatc 18001 tttatttaca ccagttttta attttacaaa agacccatga cgagttcttg ttgatatcat 18061 agattccttt cttgtaagaa ccattttaac tggtcttctt gtcatttttg ataatgcggc 18121 tgctactggt tcaattgtaa gttctaattt tccaccaaat gagcctccaa tagcaggtct 18181 tataactctt actttattta atgacatccc aaaaatttga gatagtatta ttctaaatcc 18241 aaatgtattt tggcaaggtg tatgtacagt taatttatca ttataatcat agtgtgcaat 18301 tacactatga gtctctattg cactatgatg tattgctgga gtagagtatt catcttcaaa 18361 tatatagtca cattccttga agcctttttc tacatctccc ccatttatgt tgttttgaga 18421 aactatattt gaatctccat gtatgcagat agcatcttct tttattgcat cttgtatagt 18481 aaatacagct ggcaattctt catattcaac ttttataagt tttacagctt tctctgctat 18541 ttctggagtc tctgcagcta ctgctgcaac acggtcacca acaaatctaa ctgtatctga 18601 aaatataact tcattttcag gtatattgtg ctcataaaat cttaatgaac cattgtattt 18661 tctttgtgat gtattgagat aagtagctat agctctaaca cctactactt tctcagcttc 18721 acttgtatct atacttttta tttttgcatg tgctacagga cttaaaagca tcttagcgta 18781 aagtacattt tgtggtttca tatcagccac gtatttcatt tgaccagtaa cttttaaagc 18841 tgcatctttt agagggtatg attttcctat taccttttcc at //