LOCUS NC_013315:8 18516 bp DNA linear BCT 07-SEP-2013 DEFINITION Clostridium difficile CD196 chromosome, complete genome. ACCESSION NC_013315 SOURCE Clostridium difficile CD196 chromosome, complete genome. COMMENT locus start: 1679000; locus end: 1697515 COMMENT n1_4mer:GRV/n1_4mer:RV = 3.160034; n0_4mer:D = 18.598006; n0_4mer:PS = 34.401267 FEATURES Location/Qualifiers source 1..18516 /organism="Clostridium difficile CD196 chromosome, complete genome." gene 556..1329 /gene="" /locus_tag="" /db_xref="1679555..1680328" CDS 556..1329 /gene="" /product="hypothetical protein" /translation="MSNNLQVFKNSDFGEIRVIDLNGEPWFVGKDVAETLGYKDTSDA LKRHVDDEDKGVGEIPTPGGNQNMKIINESGLYSLILSSKLLTAKKFKHWVTRDVLPS IRKTGTYSSKKSECSKDDSEIKYMNAQTRLKNARAREAKIYLELADKVDIKEYKQIMY SKTIELLSGETLIPLPKMERKTYSATDIGKMLGISANKVGGLAKALNLNVSTVSAKLR NANRLKYIEAKNIQLMFFPNLSTEYLFEIEDEVKEKYRG" gene 1335..2138 /gene="" /locus_tag="" /db_xref="1680334..1681137" CDS 1335..2138 /gene="" /product="phage anti-repressor" /translation="MNNLQVIERNNERVLTTQQLADVYETDVRNISNNFNNNKDRFIE GKHYFLLQGDDLKNFKGIHTEYENLKFTSKMYLWTERGANRHCKILDTDKAWEQFDNL EESYFNKKKDTLITNQLSPELQLFKQIFDTVAKQEIEQKQIKQDITETKQEIKSIKDV VTLNTTDWREETRKLIVSMAQNLGGNEYINTLRKESYELLCKRFNVDLKRRLNNRRSK MAEKGVCKSRREKFNYLDVIQEQNYLIEGYVIVIKDMAIKYGVFMEKTN" gene 2110..2787 /gene="" /locus_tag="" /db_xref="1681109..1681786" CDS 2110..2787 /gene="" /product="hypothetical protein" /translation="MEFLWKKLINIINKIKQYRRNKKMKENNRIVSIGVDGEIDLTDK ELEMVNNFKKVMNSINNKIGIDCGISLSDKDIEDNKNILDKIASKVAWHYKKMNFEHL EMDEKFFDDFTFKFMLKFFGDIEEDELIKYLTYIKEESNELSARERIFYKIVDTLDTI ADIKIADQNKIEKEVGMCMGEDNYITYCIDEDLIKFYIKDEEELVIDKNSPLLYMLNT LFYEVHE" gene 3860..4297 /gene="" /locus_tag="" /db_xref="1682859..1683296" CDS 3860..4297 /gene="" /product="hypothetical protein" /translation="MVEVNVNVKVKVEAPEFTNALLVVANALGGLNLGKAMQIEPINI TDMKEEKKVEVKKAEKIKKVEVKEDVKEEIAEAKEEIEKNNENTTSEVKYTKEEVRTK AAQVSKAGKKDKLKELFGEFGASKLSEVKEEDYSAFMNKLESL" gene 4309..5475 /gene="" /locus_tag="" /db_xref="1683308..1684474" CDS 4309..5475 /gene="" /product="hypothetical protein" /translation="MPLQHARLSASGAHRWLHCTPSIKLEENYPPSTSIYAEEGTVAH ELAEVKLMLEYEKISEKAYNARIKKIQKSEYYNSEMEDYIQSYVENVVELVNDSKAIC DDVIVMLEERLDFSEWVPEGFGTGDVVVISDGILQVIDLKYGKGLEVSAIENPQLRLY GLGAYNQFEMLYDIDLIKTTIIQPRLDNISSEEIEVTKLLTWADNVKKKAQMAFNGEG EFVSGSHCGFCRAKNDCRKRAGDNLKLARKYDFADTFALNKYEIADILGFAKNIQDWL KDVQSYALEQAEKHGVKYPGYKLVEGRSNRKYVDEQEVAKVLLNSDYDEEKIYKPRTL KGISDMEKAIGKKSFAKLLSDLIIKPVGKATLVVESDKRSEINSIDSAKKDFEI" gene 5878..6450 /gene="" /locus_tag="" /db_xref="1684877..1685449" CDS 5878..6450 /gene="" /product="hypothetical protein" /translation="MSNQEITKLVENNLNLVHFSINRFFKSYVEQHPYLYEEFYQEGC IGLYKAALNYDSNRGKFSTVAVSYIRIEMFKALRYGEKHYRNSIEGLDVSVFEDSKRP LKDIHGFYEIQFNYDVDYIRKIARKSYLKDIDKIVDWILQDKKISDIGELLNVSSTVI CGRIKLFSKQVRDLDKFGEITSNIKSIYQI" gene 6473..7045 /gene="" /locus_tag="" /db_xref="1685472..1686044" CDS 6473..7045 /gene="" /product="hypothetical protein" /translation="MSNSVQSTKVVTGKVRLSYCNIFKSRAMVEGAEPKYSVCILIPK SDKVTLGRIKKAIDAAKEQGKTSKWGGKLPGNLKTPLRDGDAERADEAEEYVGMYFLN ANSTQKPGIVDKDLNEILDNTEVYSGCYGRVSINFFPYNSAGNKGIGCGLQNVQKLVD GEVLGGARASAEADFSDDFEYEDEEEDFLS" gene 7045..9003 /gene="" /locus_tag="" /db_xref="1686044..1688002" CDS 7045..9003 /gene="" /product="dna-directed dna polymerase i" /translation="MRTLSIDIETYSDLDIKKVGVYRYVDSANFEILLFAYAFDNEEV KVIDLVNDEELPKEVIEALNDNKVIKSAFNANFERTAISKFLNINLKPNEWSCTMIKA LTLGLPGSLDSVSKALKFNEDKQKMKEGKALIQYFCKPCKATKVNKGRTRNLPIHDME KWNKFKEYCKQDVVVEREIRNKLSKYKTTEREIKLWYLDQRINDTGIKVDTELIENAI ECDKRYTEKLTKEAIKITGLNNPNSPAQLKKWLSDKVGFEITSLTKESIPEILKQVDD ENVVRILELRKLMSKTSIKKYEAMKLAKGNDNRVRGLLQFYGANRTGRWAGRLVQVQN LPQNHIEDLDLARNLLKEGDFDLIELLYDSVPDVLSQLIRTAFIPSEGHRFIVSDFSA IEARVIAWLAGEKWRLDVFNSHGKIYEASASQMFKIPIENIKKGSELRQKGKLAELSN GYGGSVGALISMGAIKMGLKEEELQPIVTAWRNANPNITKFWWDVDKAAKKAIKDRTI VEIQHGIKFIYNPGVLFIELPSSRRLSYLRPKIEPHTTFSGDKITYEGMEQTSKQWKR IDTYGPKLVENIVQATARDCLREAMFNVTDAGYSIVMHVHDELVIDVDKKGGSLEEVN SIMGKEISWAKGLPLKADGYECDYYKKD" gene 9015..11432 /gene="" /locus_tag="" /db_xref="1688014..1690431" CDS 9015..11432 /gene="" /product="virulence-associated protein e" /translation="MDIKASEIEHINVRHDGQLMLAIGKNKLETHWKNKSILWSELVN RLSKTLRTQETYTEYRKMSKTEKDRVKDVGGFVGGSLKNGRRKAENIANRSIITLDID YANKDIWEDITLLNDYACLMYSTHSHTENNPRYRLVIPLTRPVLPEEYQAISRMIADT IGIDMFDDTTYQPHRLMYFPSTSIDGDYIFKFQDGEFLNPNEILDLYLDWTDVSYWPE SSRERQKFNTQLKKQQDPIEKAGIIGAFCRSYSIKETIETFLNEVYIPGIDETRYTYS EGSTSGGVVIYDDKFSYSHHGTDPASGILCNAFDLVRIHKFGELDEDAKPETPVNRLP SFTRMSEFASSDTKVRKTIGRENLDKAKDDFGDIDFEDDEWLTRLDYDNKGSYKKTTN NILMFIENDPYLKGKIAYNEFSNRAVVLGKLPWRKDDKLNDWNDSDDSGLRHHIETIY NISSPSKVNDALIIAFENNTFHPIKDYLNSLKWDGIKRVDTLLIDYLGAEDNHYTRTI IRKVLVAAVARVFNPGIKFDNMMVLSGPQGMGKSTFIKKLGGDWYSDSLTTVQGKEAY EQLQGVWLLEMGEMMATKKADIEAVKHFLSKSEDIYRVAYGKRTSRFLRQCVVIGTTN DKEFLRDKTGNRRFWPIDTGVKKVNKSIFNGQLDNERNQIWAEAVELCKANEQLYLSD EEKKEAERQQRTHSEENAKSGIIEEYLNKPITENWYDLSISEKREYIHGSDFGDLKEG TILREKTCVMEIWVELFNGEPKQLTPILSREINDILKGLDDWISYNGNLRFGKIYGRQ RAYVRKS" gene 11989..13359 /gene="" /locus_tag="" /db_xref="1690988..1692358" CDS 11989..13359 /gene="" /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /translation="MEFKPHPYQEYTIRKTIDNNNIGLLLDMGLGKTVCTLTAISELM YDYFDISKVLVIAPLRVARDTWSSEVKKWEHLKHLKVSKVLGSKLDRVRALSTDSDIY IINREMVPWIVDFYKRKWPFDMVVIDELSSFKSNKAQRFKSLKKVLPLTKRVVGLTGT PTPNSLIDLWAQMYLLDRGERLGKTITGYKERYFEPGQKNYQTGAIYNWQPKNGAENA IHNKIKDICISLKAEDYLNMPRKIDNKIEIHLDSKILKYYKELEKEKILELDRDIITA SSAAVAANKLLQLANGAIYDNDKNVKELHREKLEALKEIIDVSNGKPIIVFYNYKHDY NRLMKEFKSLKPRTIENSKDIYDWNNGRIQLLLCHPASTGHGLNLQSGGSIIVWFGLT WSLELYQQANARLYRQGQRETVIIHHLICKGTIDEQVMEAIENKDKGQSALLEAVKAK LKEYRE" gene 13513..13992 /gene="" /locus_tag="" /db_xref="1692512..1692991" CDS 13513..13992 /gene="" /product="hypothetical protein" /translation="VDKESIKEIVRELRKEEREDRKKGVLYNTRLLMKHYNDFKRHID SAVSEAKDVDYLEDDLGKLDNEELYILSIKKSKARTIIMIAHIDSAMKTLKLRQERLH SYEKYRALELYYCDEKTYEEIAEILNCGVVTSRRWINEMVKELGVYLFGIDGLKLTV" gene 14275..14727 /gene="" /locus_tag="" /db_xref="1693274..1693726" CDS 14275..14727 /gene="" /product="hypothetical protein" /translation="MLKILQEKNVRMIWSKNGEEVWFNANDVGEELGIVNIRDTLRNI DREYKKKFNESTVGDSYTRNFKDKLPNFGTTFVTEEAVYNMSFRSNKAEAKLFTKWVT KALKQIRIHGYYIATEKDQEWLDIRTEGKRSEKILQMKYKSFFINTST" gene 15019..15993 /gene="" /locus_tag="" /db_xref="1694018..1694992" CDS 15019..15993 /gene="" /product="hypothetical protein" /translation="MSNFKKRYIDVYRIDIINKINGSVYSDEEILKEVIKTFFKDKEY CKENKNGINITKDKKFWITEVKCSEDDLIIKVKLEYTKYNQNTNIINAHTKEVEGNKK MDQGDSNKQHLFIKFMKENNIAVVLFERVFVGVPMIELSKNLHLYYEDMIENNKFDNN MSKTSINITQIASKDFIEQILDLDGVSKITLNVDREKFGTDEDNLFSNLNNSRRHNDL IYKPTFRTRYLPSEVKRCCEKYIKGEEFRNKKINRIIIEGEKNKRKLKLDTEGIKLCR EIEVSLDIDNHIDSEDIFEKMNNLIDDLIENNSVFFNLMYQEVAMSEA" gene 16014..16523 /gene="" /locus_tag="" /db_xref="1695013..1695522" CDS 16014..16523 /gene="" /product="hypothetical protein" /translation="MYKKVLNILLNYYKAINSKEVVELVLTPVLICIISYMFFNSSIN KEVVISLNKDVLTLSGLLVAFGVCIITLLFTTYNKSISEAKDIKTERKVNGFNISYFQ FIQLKAYYTVIMEILVVVICFINTIMLTRYYSNIIFYVLIFFTVHIILSLTTLIISMF HLSWKDRGD" gene 16593..17285 /gene="" /locus_tag="" /db_xref="1695592..1696284" CDS 16593..17285 /gene="" /product="phage DNA-binding protein" /translation="VQDVKEKVKQDYLKGMKQKEISAKYDISLNTLKSWIKRYNWSSE KKKGAPINKRGAPFSNKNSVGYGAPKENKNAEKFGFFSKYLPEETRELIQEISIKDKF DILWEQITIQYAAIIRAQKIMYVKDKEEMIKELKKHEITENSEKIEYEFQFAWDRQAS FLNAQSRAMSELRSLIKQYDEMIHKDWNLATEEQKTRVEKLKCEVANLNKDDIGDDEL KISVDYGDRNDS" gene 17263..18516 /gene="" /locus_tag="" /db_xref="1696262..1697515" CDS 17263..18516 /gene="" /product="phage terminase large subunit" /translation="MVIEMIVRINFNPDFKEANFTKKRYRAMKGSAGSGKSVNVAQDY ILKLGDKKYQGANLLVVRKSEATHKYSTYAELTGAINRIYGKQADKYWKTTLNPLEIK SKVTGNSIIFRGVNDAKQREKLKSINFSKGKLTWVWCEEATELMESDIDILDDRLRGI LTNPNLYYQMTFTFNPVSATHWIKRKYFDYKNDDIFTHHSTYLQNRFIDEAYYRRMQM RKEQDPEGYKVYGLGEWGETGGAILKNYVIHEFPTEFEYFDNMRLSQDFGFNHANAIL RIGFKDGELYICNEIYVHEMDTSEIIKIANSRGLEKTLFMYCDSAEPDRIKMWKSAGY KAKGVKKGPGSVKAQIDYLKQLRIHVHPSCTNTIKEIQQWKWKQDERTGLYLDEPVEF MDDAMAALRYSIDNKLKNNGISFLK" ORIGIN 1 tacctacacc atttaaaagc cactctttat taacattgaa tacatcacac atataattga 61 taaacaaagg ttttggttca actctattat attctatatt acttataaca tctttactaa 121 cacctagttt ttccccaaaa gctggttgag ataaattagc atcttttctt atctttctaa 181 ttcttgtgct tatagtttca ttagacaatt atatcacctc ccctaagagt attataattt 241 taagaatctt gttagtcaac aagaaaaaat aaacgaattt ttaaaatagt gttgactaac 301 aagtaaaagg atgataatat ggtgttacag aacaaggaag gcggtggata atatgagaga 361 gaaaaaaata ttagatacaa ttccaaaact tcaaactttg actgagagtg aattagattt 421 aattataaca gcagtagatt cttgtgttgt agtacaaact ttaatgaata caaaatctcc 481 aaaagatttt acaagtaaac tatcaaattt atttgaagtt gggagagaaa atacaaaaaa 541 ctagggggaa aaattatgag taataattta caagtattta aaaacagtga ttttggagaa 601 ataagggtta tagatttaaa tggagagcct tggtttgttg gtaaagatgt ggccgagaca 661 ttaggatata aagatacatc tgatgctttg aaaagacatg ttgatgatga agataaaggg 721 gtaggtgaaa taccgactcc tgggggtaat caaaatatga aaataattaa tgaaagtggt 781 ctttactctt taatattaag ttctaagttg ttaactgcta aaaaatttaa acattgggta 841 acaagagatg tattaccatc tattcgtaaa acaggtacat atagtagtaa aaaatctgaa 901 tgtagtaaag atgactcaga aataaaatac atgaatgctc aaacaagatt aaaaaatgca 961 agagcgagag aagcaaagat ttatttagag ttagctgata aagtagatat aaaagaatat 1021 aaacagatta tgtactcaaa gactattgaa ttactttctg gagaaacatt aataccactt 1081 cctaaaatgg aaagaaaaac ttattcagct acagatatag gtaagatgtt aggaatttca 1141 gctaacaaag ttggaggatt agcaaaagca ttgaatctaa atgtaagtac agtgtctgca 1201 aaattaagaa atgctaacag gttaaagtac atagaagcaa aaaatataca attaatgttt 1261 ttcccgaatc taagtactga atatcttttt gaaattgaag atgaagttaa agaaaaatat 1321 agggggtaac aaacatgaat aacttacaag taatagaaag aaataacgaa agagttttaa 1381 ctacacagca actagcagat gtatatgaaa cagatgtaag aaatataagc aacaatttta 1441 acaataacaa agatagattt attgaaggta aacattattt tttattacaa ggtgatgatt 1501 taaagaattt taaaggtatt catacagaat atgaaaacct aaaatttact tcaaaaatgt 1561 atctttggac tgaaagagga gcaaacagac actgcaaaat attggatact gacaaagctt 1621 gggagcagtt tgataactta gaagagtctt actttaacaa aaagaaagat actttaatta 1681 caaatcaatt aagtccagaa ctacaactgt ttaagcaaat atttgatact gtagcaaaac 1741 aagaaataga gcaaaaacaa ataaaacaag atataacaga aactaaacaa gaaataaaaa 1801 gcataaaaga tgttgttaca ttgaatacaa ctgattggag agaggaaaca cgcaagttga 1861 tagtatcaat ggcacaaaat ttaggtggaa atgaatatat aaatactctt agaaaagaaa 1921 gttatgaact tctttgtaaa agatttaatg ttgacttgaa gcgaagatta aataatagaa 1981 gaagtaaaat ggcagaaaaa ggtgtatgca agtctagaag ggaaaaattt aattacctgg 2041 atgttataca agaacaaaat tatttaatag aaggttatgt aattgtaata aaagatatgg 2101 ctattaaata tggagttttt atggaaaaaa ctaattaata ttattaataa aattaaacaa 2161 tataggagga ataagaaaat gaaagaaaat aatagaatag tgagtattgg agttgatgga 2221 gagatagact taacagataa ggaattagaa atggtaaata attttaagaa agttatgaat 2281 agcattaaca ataaaatagg tattgattgt ggaatttcac ttagtgataa agatatagaa 2341 gataataaaa acatattgga taagattgca tcaaaagtag catggcatta taagaaaatg 2401 aattttgaac acttagagat ggatgaaaaa ttctttgatg attttacttt taagtttatg 2461 ttaaaattct ttggtgatat agaagaagat gaattaataa aatatcttac ttatataaaa 2521 gaagaaagta acgaattgag tgctagagaa aggatatttt ataaaatagt agatactctt 2581 gatacaatag cagatataaa aatagcagac caaaataaga tagaaaaaga agtaggtatg 2641 tgcatgggcg aagataatta tataacttat tgtatagatg aagacttaat aaaattttac 2701 attaaagatg aagaagaatt agttatagat aaaaatagtc ctttgctata tatgttaaac 2761 acactatttt atgaagtaca tgaataataa aagtatttta ctagtaaaga ttaaatacaa 2821 ttaatttaat tttaaattag agaaaatagg gaggacaaaa catgagtaaa agaaaaaaaa 2881 gaagtaaaag aattcttaaa acctttatta agtaaaagag agataaaaca tttaatggat 2941 gcgcttgatg caaatatgat tatatgtgtt gagggtgtac aattaccaag agggaagtca 3001 acattagtag atttattgaa tgaaaacggt tatagagcta taaaagattg tgatgttttt 3061 aagatagagc ttaataaacc catacaaaaa acaccacaaa aataaaaata tctactttat 3121 agagaaaaat ttggaacttt tagatatatt aaaaatccaa ctatatgcac attaataaaa 3181 atagcgggct atttagatgt taccttagat gaattagttg ggaaataaaa aacagaatat 3241 tttgataata atgaggggat taaaaaatgg ataacacaaa tgaaatagtt aaaagattta 3301 gtgatagctt aaaaagctta atagaaatag agataagtaa acaagagaca gatagagtta 3361 agagtcaaac tattgaacaa aaggtaaagg tactggagcc taaagatata gttgttttaa 3421 taaaaagagg ttatccaaat tatctaataa cagtagaaga agcaagggga attttaaagt 3481 tagatacagc ttttatgcgt aggttagtaa gcacaggttt gataaaatca ctagttagag 3541 gtgatggtag aaaaatttca agatatgaag ttgatgattt tattgaaaga aatcaaggta 3601 aaaatttgga tgaactttta aaagcagtag agagggggga tgaaattgct gagtcttgat 3661 actaataata agaatgtagt aactcttaaa aaagatggaa aagttatagc agatatagta 3721 tttaaagata ttaaaactgg taagaaaata tcggttggaa tattaaataa aaaagtgttg 3781 gtaaaataac caacacacaa aaaaataaaa aataaaatat aacacaagta aagtataaca 3841 caaaaaggag agatttaaaa tggttgaagt taatgtaaat gtaaaagtta aagtagaagc 3901 accagaattt acaaatgcac tattagtagt ggcgaatgct ttaggaggtc ttaatctagg 3961 aaaagcaatg cagatagaac ctataaatat aacagatatg aaagaagaga agaaagttga 4021 agttaaaaaa gctgaaaaga ttaaaaaggt agaagtaaaa gaagacgtta aagaagaaat 4081 agcagaagca aaggaagaaa tagaaaagaa taatgaaaat acaactagtg aagttaaata 4141 cacaaaagaa gaggtaagaa ctaaggcagc acaagtaagt aaggcaggta agaaggataa 4201 gcttaaggag ttatttggtg aatttggagc tagtaagtta agtgaagtaa aagaagaaga 4261 ttattcagct tttatgaaca aattagaaag tttatagggg gtacataaat gccattacaa 4321 catgcaagac ttagtgcgag tggagcccat agatggcttc actgcactcc tagtataaaa 4381 ttagaagaaa actatccacc atcaactagt atatatgcag aagaaggaac agttgcacat 4441 gaattagcag aagttaaatt aatgctagag tatgaaaaaa taagtgaaaa ggcatataat 4501 gcaagaatta aaaagataca gaaaagtgag tattataact ctgaaatgga ggactatata 4561 caatcttatg ttgagaatgt agttgaatta gtaaatgata gtaaagctat atgtgatgat 4621 gtaatagtga tgttagaaga aagactcgat tttagcgagt gggttccaga aggatttgga 4681 acaggagacg ttgttgtaat atctgatggt atacttcaag ttatagacct aaagtatgga 4741 aaaggtttag aagtttcagc tatagagaat cctcaactta gactatatgg tttaggggca 4801 tataatcagt ttgaaatgct atatgatatt gatttaatta aaacaacaat aattcaacct 4861 agacttgata acatatcaag tgaagaaata gaagttacta aattacttac atgggcagat 4921 aatgttaaga agaaggctca aatggctttt aatggtgaag gagagtttgt aagtggcagt 4981 cattgtggat tttgtagagc taaaaatgat tgcagaaaaa gagctgggga taaccttaaa 5041 ctagctagaa aatatgattt tgctgacaca tttgctctta ataaatatga gatagcagat 5101 attttaggtt ttgctaagaa tatacaagat tggttaaagg atgttcaaag ttatgcacta 5161 gaacaagctg aaaagcatgg tgttaaatat ccaggatata agcttgtaga aggcagaagt 5221 aatagaaagt atgtagatga gcaagaagtt gctaaggttt tattaaattc agattatgat 5281 gaagaaaaaa tttataagcc aaggacctta aaaggaatta gtgatatgga gaaagctata 5341 ggtaaaaaga gttttgctaa actactaagt gatttaatta taaaaccagt tggaaaagct 5401 actttagtag tagaaagtga taaaaggtca gaaattaata gtatagattc agcgaaaaaa 5461 gattttgaaa tataaatggg ggatattaca tgccattaga tgcaggtata aaagataaat 5521 tagatgaaag cataagtata attttagatt taaaggagag aaaaaagagt atcgaaaaag 5581 atttagatta tgaaaaagat aatttactag atatgttaaa gagactaaat attacagaat 5641 ataactcaac tgaagaaaat gcaaaagtta cagtgatgga ttttaaaaga gaaagtttaa 5701 taaaggataa agtgatgtca actttcctcg aagtaaatga caatcatctt gatagagtgt 5761 atataccaga acatataaaa gttagtccag tatgctttgt atcagtaaga gcaaaggata 5821 tttaaaaata tttaattcct agtagctata aaaagattta aaaggggata taattttatg 5881 agtaatcaag aaataactaa actagttgaa aataatttga atcttgtaca ttttagtata 5941 aatagatttt ttaagtctta tgtagagcaa catccatact tatatgaaga gttttatcaa 6001 gaaggatgta ttgggttata taaagcagca ttaaattatg atagtaacag aggcaagttt 6061 tctacagtgg ctgtttctta cataagaata gaaatgttta aagctttgcg ttatggcgaa 6121 aaacattata gaaactctat agaaggttta gatgtaagtg tatttgaaga tagtaaaaga 6181 ccattaaaag atatacatgg attttatgaa attcaattta actatgatgt tgattatata 6241 agaaaaattg caagaaagtc atatttaaaa gatattgata aaatagtaga ttggatttta 6301 caagataaaa agatatctga tataggagag ttattaaatg tttcttcaac agttatttgt 6361 ggaagaatta aattgtttag taagcaagtt agagatttag ataaatttgg agaaataact 6421 tcaaatataa aatcaatata ccaaatataa aaatattagg aggaagaaaa ttatgagtaa 6481 ttcagtacaa tcaacaaagg tagtaacagg aaaggtaaga ttaagttatt gcaatatctt 6541 taaaagcaga gcaatggtag aaggtgcaga gcccaagtat tcagtttgta ttttaatacc 6601 aaaatcagat aaggtgactt taggaagaat aaagaaggct attgatgcag ctaaagaaca 6661 aggtaaaact tctaaatggg gtggaaaatt accaggtaat ttaaaaacac ctcttcgtga 6721 tggagatgca gaaagagctg atgaagcaga ggaatatgta ggaatgtatt ttttaaatgc 6781 aaatagtact caaaagccag gaatagttga taaagactta aatgaaatat tagataatac 6841 agaggtatat agtggttgtt atggaagagt tagtataaac tttttcccat ataatagtgc 6901 aggaaataaa ggaataggtt gtggcttaca aaatgttcaa aagttagtag atggagaagt 6961 acttggagga gctagagcta gtgcagaagc agatttctca gatgactttg aatatgaaga 7021 tgaagaagag gacttcttaa gttaatgagg accttatcaa ttgatataga aacatatagt 7081 gatttagata taaaaaaagt tggagtctac agatatgtag actctgctaa ttttgagata 7141 ctgttatttg cctatgcttt tgataatgaa gaggtaaaag ttattgattt agtaaatgat 7201 gaagagttac caaaagaagt aatagaagct ttaaatgata ataaagttat aaaatcagca 7261 tttaatgcta attttgaaag aacagcaata agtaaatttt taaatattaa tttaaaacca 7321 aatgagtggt catgtacaat gataaaggcg ttaacactag gacttccagg aagtttagat 7381 agtgtgtcta aggctttaaa gtttaatgaa gataaacaga aaatgaaaga aggtaaagca 7441 ttaatacaat atttctgtaa accttgtaag gctacaaaag ttaacaaggg aagaactaga 7501 aatttaccaa tacatgatat ggaaaaatgg aataaattta aagaatattg taaacaagat 7561 gttgtagttg aaagagaaat aagaaacaaa cttagtaagt ataagactac cgaaagagaa 7621 attaaattat ggtatttaga ccagagaatt aatgatactg gtattaaagt ggatacagag 7681 ttaatagaga atgcaataga atgtgataaa agatatactg aaaaacttac aaaagaagca 7741 attaaaataa ctggtctaaa taatccaaat agtccagctc aattaaaaaa atggttaagt 7801 gataaagttg gctttgagat tacaagccta acaaaagaaa gtattccaga aatattaaaa 7861 caagttgatg atgaaaatgt agttagaatt ttagaactta gaaaattaat gtccaaaact 7921 tctataaaga aatatgaggc tatgaaatta gctaaaggta atgacaatag agtaagaggt 7981 ctactacagt tttatggggc taataggact ggtagatggg caggaagatt agtacaagta 8041 cagaatttac cacaaaatca tatagaggat ttagacctag ctagaaacct attaaaagaa 8101 ggagattttg atttaataga gcttttatat gatagtgtac cagatgtctt aagtcaattg 8161 ataaggacag cttttatacc aagtgaaggt catagattta tagtgtcaga ttttagtgca 8221 atagaagcta gagttatagc ttggcttgca ggtgagaagt ggagactgga tgtgtttaat 8281 tctcatggaa aaatatatga agctagtgcc agtcagatgt ttaaaattcc aatcgaaaat 8341 attaaaaaag gttctgaact tagacaaaaa ggaaagctag cagaattatc gaatggatat 8401 ggcggaagtg taggggcctt aatttctatg ggggctatta aaatggggct taaagaagaa 8461 gagcttcaac ctattgttac tgcatggaga aatgctaatc caaatataac taagttttgg 8521 tgggatgtag ataaggcagc taaaaaagct ataaaagata ggactatagt agaaattcaa 8581 catgggatta aatttattta taatccaggc gttttattta tagaactacc aagtagtaga 8641 agattatcgt atctaaggcc taagatagag ccacatacta catttagtgg ggataagata 8701 acatatgaag gtatggaaca gacaagtaaa caatggaaaa gaatagatac ttatggacct 8761 aagttagttg agaatattgt tcaagctaca gctagagatt gcttaagaga ggctatgttt 8821 aatgtgacag atgcaggtta tagcattgta atgcatgtac atgatgagct tgtaattgat 8881 gtagataaaa aaggaggttc tttagaagaa gttaacagta ttatgggaaa agaaatatct 8941 tgggctaaag gtcttcctct taaagcagat ggatatgaat gtgattatta taagaaagac 9001 taggtgattg atttatggat ataaaggcca gtgaaattga acacataaat gtaagacatg 9061 atggccaact catgctggcc ataggaaaaa ataaattaga aacacattgg aaaaataaaa 9121 gtattttatg gtccgaactt gtaaatagat taagtaaaac attaagaact caagaaacat 9181 atacagaata taggaagatg tcaaagactg aaaaagatag agttaaagat gttggtggat 9241 ttgtaggtgg aagcttaaaa aatggaagac gaaaagcaga gaatattgca aatagaagta 9301 ttataacttt agatatagat tatgcgaata aagatatatg ggaggatata acattattaa 9361 atgattatgc ttgtcttatg tattctacgc actcacatac tgagaataat cccagatata 9421 gacttgtaat acctttaact agaccagtac taccagaaga atatcaagca atttccagga 9481 tgatagcaga tactatagga atagatatgt ttgatgatac tacatatcaa cctcatagac 9541 ttatgtattt tccaagtact tcaattgatg gagactatat atttaaattt caagatggag 9601 agtttttaaa cccaaatgaa atactagatt tatatttaga ctggacagat gtaagctatt 9661 ggccagaaag ttcgagggag aggcaaaagt ttaatacaca attaaaaaaa caacaagacc 9721 ctattgaaaa ggctggaatt ataggtgcat tttgcaggtc ctatagtata aaagaaacta 9781 tagaaacttt cttaaatgaa gtatatattc ctggtattga tgaaaccagg tatacatatt 9841 cagaaggtag tacaagtggt ggagtagtta tttatgatga caagttttca tatagtcatc 9901 atggtacaga cccagcaagc ggaattttat gcaatgcttt tgatttagtt aggatacata 9961 aatttggtga acttgatgaa gatgctaaac ccgaaacgcc tgtaaacaga ttaccttcat 10021 ttactcgaat gagcgaattt gcaagcagtg acactaaagt acgaaagact ataggaagag 10081 aaaaccttga taaagctaag gatgattttg gtgatataga ttttgaagat gatgaatggt 10141 taactaggtt agattatgac aataagggaa gttataagaa aacaacaaac aatatcttaa 10201 tgtttataga aaatgaccca tatttgaaag gaaaaatagc ttataatgaa ttttcaaata 10261 gagctgtcgt tttaggtaag ttaccttgga gaaaagatga taaattaaat gattggaatg 10321 atagtgatga ttctgggctt agacatcata tagaaacaat ttacaatatc tcatcaccat 10381 caaaagtaaa tgatgctcta ataattgctt ttgaaaataa tacttttcat cctataaaag 10441 attatttaaa ttctttaaag tgggatggca ttaagagagt ggatacactt ttaattgact 10501 atttaggtgc agaagataac cactatacaa ggactataat aagaaaagtt ttagtagcag 10561 cagtagcaag agtatttaat ccaggaataa agtttgataa tatgatggtt ttatctggtc 10621 ctcaaggaat gggaaaaagt acttttatta aaaaacttgg tggagactgg tattctgata 10681 gtttaactac tgtacaaggt aaagaagcgt atgaacaatt acaaggagta tggttgctgg 10741 aaatgggtga aatgatggct actaaaaaag cagatattga ggcagttaag cattttctaa 10801 gcaaatcaga ggatatatat agggtcgcat atgggaagag aacatcaagg tttttacgtc 10861 aatgtgtagt tataggaaca actaatgata aagaattttt aagagataag accgggaata 10921 gaaggttttg gccaatagat acaggagtaa agaaggttaa caagagtata tttaatggtc 10981 aacttgataa tgaaagaaat caaatttggg cagaagcagt agaattatgt aaagccaatg 11041 aacagctata tctatcagat gaggagaaaa aagaagctga aagacaacaa agaactcact 11101 cagaagaaaa tgctaaatct ggaattatcg aagagtatct aaataaacct attactgaga 11161 attggtatga tttaagtatt tcagaaaaga gagaatatat tcatggttca gattttggtg 11221 atttaaaaga aggaacaata ttaagagaaa aaacgtgtgt tatggagata tgggttgagc 11281 tatttaatgg agaacctaaa caactcacgc ctatcttatc aagagaaatt aatgatatat 11341 taaaaggatt agatgattgg atatcatata atggaaattt aaggtttggg aaaatatatg 11401 gtaggcagag agcttatgta cgtaaaagtt agtgtcaaca gaattaaaaa cagagtaaat 11461 ttgaaaattt taaaagtgtc aacaatgtca acaaaaaaaa tggctttgtt gacgcttatg 11521 ttgacaccta agatgcagta attacaatgt ttgaggtatt aatgtcaaca atgtcaacaa 11581 aaattaagta taaagtagta taagtaatat taggcatata cgtatataca tatgtatgcc 11641 taatatgtat atatacatat atatagaaaa tctgttgaca ttgttgacac ttaaatttta 11701 aggaagtgat attttgttag aatcaaaaat agaaaaaaga cttaaaaaag agattgagtt 11761 gttaggtgga aaggctatga agtttatttc accaggtgag gcaggtgtgc cagataggat 11821 tgtcttatta ccagaaggac atgttatatt tgtagaactt aaagcaccag gtaaaaaact 11881 aaggaagctt caacaatata aaatgcgaga attaagagaa ttaggattta aagttaagtg 11941 tgtaagcaca ttaaaagaga tagatgattt tatcaaggag gttaagggat ggaatttaaa 12001 ccacatccat accaagaata cacaattaga aaaactatag ataataataa tataggttta 12061 ctattagata tgggattagg taaaacagtc tgtactctaa cagctataag tgaattaatg 12121 tatgattact ttgatatatc aaaagtttta gttatagcac ctttaagagt tgcaagagat 12181 acctggagta gtgaagtaaa aaaatgggaa catctaaagc atctaaaagt atctaaagtt 12241 cttggtagta aattagatag agtgagagct ttaagtacag actcagatat ttatataata 12301 aatagagaaa tggtaccctg gatagtggat ttttataaaa gaaaatggcc atttgatatg 12361 gttgtgatag atgaacttag ttcttttaaa tcaaataaag cacaacgatt taaaagttta 12421 aagaaagtat tgcctttaac taaaagagta gttgggctta ctggtacacc aacaccaaat 12481 agtttaatag acttatgggc acagatgtac ttacttgata gaggtgaaag actaggtaaa 12541 actattacag gatataaaga acgatacttt gagccaggac aaaaaaatta tcaaacagga 12601 gctatatata attggcaacc taaaaatgga gcagaaaatg caatacataa taaaataaaa 12661 gatatttgta taagcttaaa agcagaagat tatttgaata tgcctagaaa aatagataat 12721 aaaattgaaa tacaccttga tagtaaaata cttaaatatt acaaagaatt agaaaaagag 12781 aagatattag aattagatag agatataata acagcttcat cagcagctgt agcagcaaat 12841 aaacttttac aattagctaa tggagcaatt tatgataatg ataaaaatgt aaaggaactc 12901 catagagaaa aattagaagc tttaaaagaa attatagatg tttcaaatgg taagcctatt 12961 atagtttttt ataactataa acatgattat aatcgtttaa tgaaagagtt taagagtttg 13021 aaaccaagaa caatagaaaa ctcaaaagat atatatgatt ggaataatgg aagaatacaa 13081 ttattacttt gtcatccagc aagtacagga catggactta atttacaatc aggtggaagt 13141 ataattgttt ggtttggatt aacttggagc ttagaactgt atcaacaagc taatgcaagg 13201 ctttatagac agggtcaaag ggaaactgtt attatccatc atctaatctg taaaggtaca 13261 atagatgaac aagtaatgga agctatagag aataaggata aagggcaaag tgcattactt 13321 gaagcagtaa aagcaaaatt aaaagaatat agggagtgaa ggtatgaaag taaaaagaaa 13381 agatggaact tataagccca ggtaaaatag taagatgtgc ttggtgtggt agaagatttt 13441 ataagttgga taaatctaaa gttgagtatt gcagtagaag ttgttcgaag agagcaagaa 13501 ggagtgattt aagtggataa agaaagtata aaagaaattg taagagagtt aagaaaagaa 13561 gaaagagaag ataggaaaaa aggcgtttta tataatacta gattattgat gaagcattat 13621 aatgatttta agagacatat agactcagcg gtaagtgaag ctaaagatgt agattactta 13681 gaggatgatt taggtaagct tgataatgaa gagttgtata ttttaagtat aaagaaaagt 13741 aaagcaagaa ctattattat gatagcacat atagattcag caatgaaaac tttgaaatta 13801 agacaagagc gtttacattc ttatgaaaag tatagagctt tagagcttta ctattgtgat 13861 gaaaaaacat atgaagaaat agcagagata ttaaattgtg gagtagttac atcaagacgt 13921 tggattaatg aaatggtaaa agaacttgga gtgtatttat ttggtataga tggcttgaaa 13981 ttaactgttt gataaataca tgataaaaag atgatatttt aatgatattt aacccctgtt 14041 ataatggtag tatgaaacaa gtgtataata tattccccct tgaaaaaggc taagttaccc 14101 caacttagtc ttttttattt tgtaaataag gagaatgata aatgagtaat tcatgactta 14161 gagtgatttc taggtctttt tttatacaat tttaatctct catattgaag ggtcgaaaat 14221 aagggtgttc aaattgaata ttctttatta ataactaatt taggaggtag tagtatgttg 14281 aaaattttac aagagaaaaa tgtaaggatg atatggtcaa aaaatggaga agaagtttgg 14341 tttaatgcaa atgacgtagg agaggaacta ggcatagtaa atattcgtga tacattaaga 14401 aatatagata gagaatataa aaagaaattt aatgagtcta ctgtcggaga ttcctacact 14461 agaaacttta aagataaatt gcctaacttt ggtactactt ttgttacaga agaagctgtg 14521 tacaatatgt catttagaag taataaagca gaagcaaaac tatttacgaa gtgggttaca 14581 aaagcactta aacaaattag aatacatggt tactatattg ccacagaaaa agatcaagaa 14641 tggctggata taagaacaga aggtaaaagg tcagaaaaga ttttacagat gaaatacaag 14701 agttttttta ttaatacaag tacttgaaag agttatatct atgaaattac ctaggttgat 14761 agataaaggt atgaattata aagaggtata taaaaagatt aaagaattaa tcgaaatgat 14821 ttaaatgact gtattaatag agggtctttt tttttatgta atgaattaaa aatgaaatat 14881 atttgtacat tatagacagg aataaggtaa aagtattatt tagacttatt ttgtggttgt 14941 cgaatgatta ttgaaggata ttgactgatt atatagaatt atatcattat aaatatttgt 15001 gaaaggaata atggtataat gagtaatttt aaaaaaagat atattgatgt ttatagaata 15061 gatattataa ataaaattaa tgggagtgtc tattcagatg aagaaatttt aaaagaggta 15121 ataaagacct tctttaagga taaagaatat tgtaaagaaa acaaaaatgg aattaatatt 15181 actaaagata aaaagttttg gattacagaa gtaaaatgta gcgaggatga tttaataatc 15241 aaggtgaaac ttgaatatac taaatacaat cagaatacaa atattataaa tgctcatact 15301 aaagaagtag agggtaataa aaaaatggat caaggagata gcaataagca gcacctattt 15361 attaaattta tgaaggaaaa taatatagca gtagtattat ttgaaagagt ttttgtgggg 15421 gttcccatga ttgaactaag taaaaactta catctatatt atgaggatat gattgaaaat 15481 aataaatttg ataataatat gtcaaaaaca tcaattaata ttacacaaat agcaagtaaa 15541 gattttatag aacaaatatt agatttagat ggtgtttcaa aaataacttt aaatgttgat 15601 agagagaagt ttggaactga tgaagataat ttgttttcta atttaaataa ttcaagacga 15661 cataacgatt tgatatataa gcccacattt agaactagat atttacctag tgaagttaaa 15721 agatgttgcg aaaaatatat taaaggagag gaatttagaa ataaaaaaat aaataggata 15781 ataattgagg gagagaaaaa taagagaaaa ttaaagttgg atactgaggg tataaagttg 15841 tgtagagaaa tagaggtttc tcttgatata gataatcata tagatagtga agacattttt 15901 gagaagatga ataatttgat agatgattta attgagaata attcagtttt ttttaattta 15961 atgtatcaag aagttgctat gagtgaagca tagattgcta aggaggtgtt aaaatgtata 16021 aaaaggtatt aaatatctta ctcaattatt acaaggctat aaattctaaa gaagtagtag 16081 agttagtttt aacaccagta ttaatatgta ttatttcata catgtttttt aattcgtcaa 16141 ttaataaaga agttgtaatt tctttaaaca aagatgtact aactttgtca ggactattag 16201 tagcttttgg agtttgcatt attacattat tgtttactac atataacaaa tcaatatcag 16261 aagcaaaaga tataaaaaca gaaagaaagg taaatggatt taatatatca tactttcaat 16321 tcatacagtt aaaagcatat tatactgtaa taatggagat tttggttgtt gtaatatgtt 16381 ttatcaatac aataatgctt actcgatatt attctaatat aattttctat gttttaatat 16441 tttttacagt tcatataatt ttatctctaa ctacattaat aataagtatg tttcatttat 16501 cctggaagga tagaggagac tagatttgaa acaatcctat taaataggat tgttttttta 16561 ttcccaaaac aaacaaataa agaggtggtg atgtgcaaga tgtcaaagaa aaggtaaaac 16621 aagattactt aaaaggaatg aaacaaaagg aaatatcagc aaagtatgac attagtttaa 16681 atactttaaa gtcatggata aaaagataca attggtctag tgaaaaaaag aagggtgcac 16741 ctataaataa aaggggtgca cccttttcta ataaaaattc agttggttat ggtgctccaa 16801 aagagaataa aaatgctgaa aagtttggtt tcttctcaaa atacttacct gaagaaacta 16861 gggaattaat acaagaaata tctataaaag ataaatttga tattctttgg gaacagataa 16921 caattcaata cgcagcaata ataagagcac agaagataat gtatgttaaa gataaagagg 16981 aaatgattaa ggaattaaag aaacatgaaa tcacagaaaa tagtgagaag atagagtatg 17041 aatttcaatt tgcatgggat aggcaagcat cttttcttaa tgcacagagt agagctatga 17101 gtgagttaag gagtttaatt aagcagtatg atgaaatgat tcataaggat tggaatttgg 17161 ctacagagga gcagaaaaca agagttgaga agttgaaatg tgaggttgct aacctaaata 17221 aagatgatat tggagatgat gagttgaaaa taagtgtaga ttatggtgat agaaatgata 17281 gttagaataa attttaatcc agatttcaag gaagctaatt ttactaaaaa aagatacaga 17341 gcaatgaaag gttcagcagg gagtggaaaa tctgttaatg tagcacaaga ctatatacta 17401 aagttaggag ataagaagta tcaaggagct aatctattag tagttagaaa gtcagaagct 17461 acacataagt attcaacgta tgcagagctt acaggagcta taaatcgtat ttatggtaaa 17521 caagctgata agtattggaa aactacttta aatcctttag aaattaagag taaagttact 17581 ggtaactcta taattttcag aggagttaat gatgcaaaac aaagagaaaa attaaaatca 17641 attaacttct cgaaaggaaa attaacatgg gtttggtgtg aagaagctac agaacttatg 17701 gaaagtgaca tagatatact agatgaccgt ttaagaggta ttttaactaa tcctaacttg 17761 tattatcaaa tgacatttac atttaatcca gtctcagcta ctcattggat aaaaagaaag 17821 tattttgact ataaaaatga tgatatattt actcatcata gtacttatct acaaaataga 17881 ttcatagatg aagcttacta cagaagaatg caaatgagaa aagagcaaga cccagaaggg 17941 tacaaagtat atggtcttgg agaatgggga gaaactggtg gagcaatact taaaaattat 18001 gttatacatg aatttcccac agaatttgaa tactttgaca atatgagact gtcacaagac 18061 tttggcttta atcatgcaaa tgcaatactt agaattggct ttaaggatgg agagttatat 18121 atatgtaatg aaatatatgt acatgaaatg gatacctcag aaatcataaa aattgcaaat 18181 agtagaggtt tagaaaagac tctatttatg tactgtgata gtgctgaacc agatagaatt 18241 aagatgtgga agagtgcagg atataaagct aaaggagtta aaaaaggacc aggaagtgtt 18301 aaagctcaaa tagattattt gaaacaatta agaatacatg tacatcctag ttgcactaat 18361 accataaaag aaatacaaca atggaaatgg aaacaagacg aaagaactgg attatatctt 18421 gatgaaccag ttgagtttat ggatgatgca atggctgctc ttagatattc tatagataat 18481 aagcttaaaa ataatggaat aagcttctta aagtaa //