LOCUS NC_013315:7 18100 bp DNA linear BCT 07-SEP-2013 DEFINITION Clostridium difficile CD196 chromosome, complete genome. ACCESSION NC_013315 SOURCE Clostridium difficile CD196 chromosome, complete genome. COMMENT locus start: 1370000; locus end: 1388099 COMMENT n1_4mer:GRV/n1_4mer:RV = 5.993906; n0_4mer:D = 25.236242; n0_4mer:PS = 42.427636 FEATURES Location/Qualifiers source 1..18100 /organism="Clostridium difficile CD196 chromosome, complete genome." gene 54..1877 /gene="acd" /locus_tag="acd" /db_xref="1370053..1371876" CDS 54..1877 /gene="acd" /product="mannosyl-glycoprotein endo-beta-N-acetylglucosamidase" /translation="VKKKAALATLAMLPLGVVNAHADGDIGIVTINYLNVRNEPTAES SIAFVAKKDDKVLIKDSSNGWYKIKAESGQEGWASSKYIAKSNSDSLRTSTNKEKQVI SNSLNMRNGAGTSYRVITVLKKGQKVEVISESNGWSKIKYDGRLGYVSSSYLGDVSNS TNKSKTKQVNTTSLNVRSGPNTSYGLLGKLPKGSKVEVISESNGWSKIKYNGKDAYIS SMYLSDVSQSNSDNSSQSNDKKNTDKVVNTASLNVRSGPGSTYSKLGKVYKGSKVTVL SESSGWAKINFNNKEAFVVGNYLSTSADTSNNNSNSNSDNSSNSNGNNSSSSGQVNGM SGISGAKIDYKSLSYTLESHISKQVEKAASGGNVIAPSNRKSTPSPEFSTFSAQRTSS FVNASSSDIEYYLNPKNFTNTTKGMMQFLKINSYRDGISESSLNSYLNGLSSSVFKNQ GAAFINAAKKYNIDVVYLVSHAMWETAYGKSTLAQGQTLTSYKGQPLSKPVKVYNFFG IGAIDKSANVSGAEAAYSNGWTSVEATIDGSAKWISQNYVNSSKYNQNTIYKMKWNYD YTWHQYATDVNWANGISGIMENLIGLYGGGSSLVFEVPQYK" gene 2092..6390 /gene="dnaF" /locus_tag="dnaF" /db_xref="1372091..1376389" CDS 2092..6390 /gene="dnaF" /product="DNA polymerase III PolC-type" /translation="MESIKEYLDKLEINNSGLGKQLKEVYINRVVYFKEDKIVYFYLT SKDIVSHELLDKFKEELMYKLDYFKDMRMKIRFTGLERKSNKDVIKKYWNNILYILKY LCPSIAGWYKQVEFLCLEEELKIKLPKGIFYERLMKKNVTYVLKTVLSEELGLDLNIT IEKAVDEKVNKERLIRINDREMEEKIRALEIGKVNNCEENEEESYVIKSDVDENLIYG DNANAMIENIVELNASSGTVAVVGDIFDVDTKELKNGKILMIASITDYTSSISCKLFL TDTNKDGVLENVKKGAYLKIKGDIVYDTYQREISMMISGIRKETRIEREDKSEEKRVE LHAHTQMSSMDAICSVKKLVERAAKWGHSAIAITDHGVVQGFPDAMNAGKSNNIKILY GVEGYLVEDDSLIIEDANDKELSQTFVVFDIETTGFSNTNDKITEIGAVKIENFKIVD RFSELINPEKDISYKIQELTGITNELIKDKPTIEEILPKFMEFVGDSVLVAHNAEFDT GFISQKCREQGLLYNNKKVDTLMLARVMLPNLKRHRLNVVAKELGIPLLNHHRAVDDA EATALIFNKFLQMLTEKGAKTLSDVNNILGKIDYTKLSTNHITLIAKNSIGIKNLYKI ISDAHVNHFFRAPRILRSVLNEYKEGLIIGSACEAGVVFQAVKKNVSDEEMKKIIDLY DYIEVMPIDNNRFMIDKGEVKDEEELRELNRKLIDTAKKFDKIPVATGDVHFLDKHEA VLRKVLKYSQGFKVDEEETYLHFRTTDEMLEEFSYLGEELAYEVVVENSNLIADMVED IKPIPDDTYPPIIEGSDVELREMCYKKAKRIYGDPIPEIVQKRLDRELNSIISNGYAV MYIIAQKLVAKSLSDGYLVGSRGSVGSSFAATMSDITEVNPLPAHYICENEDCKYSFF YEIGEWGSGVDLPDKDCPKCGRKLAKNGHDIPFEVFLGFEGDKEPDIDLNFSGNYQPT IHKYTEELFGEGYVYRAGTIGTVAEKTAFGYARKYVEENNISVPNAEVLRLSNGCTGV KRTSGQHPGGVMVIPDYKDVYDFTPIQYPANDTSCGVITTHFDYHSISGRILKLDILG HDGPTIIRMLEDMTGINITEIPLDDKETMSLFTSTEALGVTPEEINCPIGCLAVPEFG TKFVRQMLLDTKPTTFAELVRISGLSHGTDVWVNNAQDLVREDIVGLKDVISTRDDIM NYLIFKGLPPKMSFTIMESVRKGKGLKPEHIEEMKKNNVPEWYIGSCKKIKYMFPKAH AVAYVMTSFRIAYCKVHYPEAFYATYFTTKVEDFDADLIVKGLDAIKSKINEIESLGN DATTKEKGMLTVLEVALEMYARGIKLLPVDIYKSDATEFIVVGEKTLLPPMAAIQGLG GNAAINIQNERKNGEFISKEDLRKRTKISKTVIETLTNHGSLENMSERNQLSLF" gene 6594..7055 /gene="" /locus_tag="" /db_xref="1376593..1377054" CDS 6594..7055 /gene="" /product="hypothetical protein" /translation="MKKNLEATIEEIVTKITDEHGFEMVDVEYVKEAGEYYLRVYIDK EEGISLNECELVSRELSPILDEKDPIKENYFLEVSSPGLDRALKKDRDFVRYQGRDVD LKLYKPLNGCKQFEGELVGLTEDNNIKIIANGKEMEFNRKDVAIVRLAIKF" gene 7085..8239 /gene="nusA" /locus_tag="nusA" /db_xref="1377084..1378238" CDS 7085..8239 /gene="nusA" /product="transcription elongation protein" /translation="MNHEFMEALDELVVDRGIDKEILIDTIEQALLTAYKKNFGSAQN VRVEFDRDKGDIKVFSQRVVVDESDLYDTFLEIELADAREINPNYELGDIIEHEVTPK NFGRIAAQTAKQVVVQRIREAEREIVYNEFIEKENEIVTGEVARANKNVVYVNLGRIE GIMTQSEQIPFENYKAGQKIKFYILEVKKTNKGPQIVVSRSHPGLVKRLFEEEVPEIY EGIVQIKSVAREAGSRTKMAVKSIDEKIDPIGACVGPKGLRVKNIVDELGDEKIDIIK YSEDPAEFISAALSPSKVVRVDIDEDEKSALVIVPDYQLSLAIGKEGQNARLAAKLTN WKIDIKSESQAEQEMLNLENSKEIEAEDVEAEFIDQEELGTSEDNFSEEE" gene 8246..8527 /gene="" /locus_tag="" /db_xref="1378245..1378526" CDS 8246..8527 /gene="" /product="hypothetical protein" /translation="MILKKVKKVPQRKCIACQDRDSKKELIRIVKNKEGKIFLDPTGR ANGRGAYVCKSSECLKKAIKSKALNKAFKIDVPDEVYDNLLMELEEYEK" gene 8517..8828 /gene="" /locus_tag="" /db_xref="1378516..1378827" CDS 8517..8828 /gene="" /product="ribosomal protein" /translation="MKNNKEKVLSFLGLATRAGKIVSGDDSTLLDLKKGKVNLILIAE DASNNTKKLFKDKSTFRNIPYLFFSTKEEIGFAIGKSPRAVVGIKDENFSKKIIELIE I" gene 8850..10790 /gene="infB" /locus_tag="infB" /db_xref="1378849..1380789" CDS 8850..10790 /gene="infB" /product="translation initiation factor IF-2" /translation="VSKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELE LALEMLGEDLSQENGNVIEIDGKLTVQVLATKLDKSPSEIIMKLMKMGTMATINQEIS FEIAALAAKDYGFELTVAESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHG KTSLLDAIRKTDVISGEAGGITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQV TDIAILVVAADDGIMPQTVEAINHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGL LVEDWGGEVIAVPVSAKKKEGIDTLLEMVLLVAEMEELRANPNKRAVGTVIEAELDKG RGPVATVLVQGGTLTVGDPIVAGVACGKVRAMINAKGKRVKTAGPSTAVEILGLSEVP QGGDQFVEVPTDKIARSVAARRQQIVRDEMLKSTQRLSLDALFSQMSEGSIKDLNIVI KADVQGSVQAVKQSLEKLSNEEVQVKVIHGGVGAVTESDILLAAASNAIIIGFNVRPV PGAESLGEKENVDIRTYTIIYKAIEDIQAAMTGMLDPEYVDEETGKAEIREIYKISGV GTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELAALKRFKDDVKEVNSGYECGMSFVN YNDIKEGDIVEAYITKEVERKL" gene 10833..11213 /gene="rbfA" /locus_tag="rbfA" /db_xref="1380832..1381212" CDS 10833..11213 /gene="rbfA" /product="ribosome-binding factor A" /translation="MASYNRTRRIAEEIRKVVSTMLINGVKDPRITSMVSVTDVEVTN DLRYAYVYVSILGGDEESTLTGLKSAGGYIRREVGKNIKLRYIPEIVFKLDDSIEKGM YMDNLIKRVNEKNAQQNEDENYDE" gene 11167..12177 /gene="" /locus_tag="" /db_xref="1381166..1382176" CDS 11167..12177 /gene="" /product="RNA-binding protein" /translation="MKKMLNKMRMKIMMNNMDSIINYIYEGDYFIVTSHISPDGDNVG STLSMYYTLKNLGKNVYYVLDDEAPLNLRFLVEGVKIYKSNEFNMKNYSLIALDCGDK MRICVSDEIKNNASKLICIDHHASNDSYGDLNYVDIDASSTCELVYNLLVRFQQTKDI NIINEDIATCLYTGLVTDTGNFSYSNVHASSFEMAKNLLVLGAQKNTIIQNIYQSNSS DYYKLLGEALKGLEIFDSKVSSIVLTQDMMNRNNISFNDVDGITTYTRDIKGIEVGIL FKEKKQNEIKVSFRSKNYVDVSEIAKLFGGGGHVRAAGCTIRDSIDNAKKMVLEAVLK SI" gene 12190..13095 /gene="truB" /locus_tag="truB" /db_xref="1382189..1383094" CDS 12190..13095 /gene="truB" /product="tRNA pseudouridine synthase B" /translation="MNKIISILKPTGMTSHDVVSRVRKILNIKKVGHTGTLDPDASGV LPICIGKATKVCEVILNKDKSYICELTLGISTDTYDASGEILKKVDDFKFSNEDIERA FDTQRGEINQLPPIYSALKVNGKRMCDLVRSGRQSEITLKTRRVNIKDIKILSIKGNK VMFYVECSKGTYVRSICHDIGEYLGCGAHMSFLNRTSSGKFDLDNSITLEELELFYEN KTLDKYLYDIDYVLDSFNYVVLNPNAIKYYSNGGSIDDKRFLKNNFDKDDEVVRVYST DNFLGLGKLSKHNNTISVKSDKMFI" gene 13226..14155 /gene="ribC" /locus_tag="ribC" /db_xref="1383225..1384154" CDS 13226..14155 /gene="ribC" /product="riboflavin biosynthesis protein" /translation="MVIIKSIKEIANIKESVITIGNFDGVHKGHQVLIGKTVEYAKKE NIQSIVFTFANHPVNYFRPNSTKNIISNDDKIKLLEDLGIDIVVIIPFDEYMTKIPAK DFVDEILVKKLKAKKIVIGHDFTFARAKEGNVNLLKSLEHEFGFEVEVIKPIKINDVR VSSTYIRSLVSQGDMANVKEYLGRNYKLEGCVIHSKHLGRTIGFPTANIDLKNNMLVP KRGIYASIVHIGDETYFGATNVGYNPTVNGKTLSIETNILEFDRDIYGENIIVEFLER IRDERKFNSIDDLKNQLYNDTNYVYENYVCKNK" gene 14155..14253 /gene="" /locus_tag="" /db_xref="1384154..1384252" CDS 14155..14253 /gene="" /product="hypothetical protein" /translation="MYDKMIKENNHYSAFEYSNQCLVIGVSKKIRR" gene 14259..14516 /gene="rpsO" /locus_tag="rpsO" /db_xref="1384258..1384515" CDS 14259..14516 /gene="rpsO" /product="30S ribosomal protein S15" /translation="MINKSEIIKEYGRAEGDTGSPEVQIALLTARINELNGHLKTHKK DHHSRRGLLKMVGRRRNLLAYLKEKDLEGYRALIAKLGLRK" gene 14756..15601 /gene="" /locus_tag="" /db_xref="1384755..1385600" CDS 14756..15601 /gene="" /product="hypothetical protein" /translation="LKIKLVCDSLCDIPDEISEKDYIEIVPLTVIFNDREYIEGVDIK KEEFYKKVKEIKQIPKTSQATYMEFKEVFDKFITEGYHIICMTGAANASGTFQSAMIA KNDVNENEKIHIFDTRNLSLGSGQYVIKACELLEEGLGFEEIIDELENTRSSVRLLFA PYTLDFLKQSGRVPVATALIGNMLNIKPIFFFDNGEAKLVNKVRGIKNIASKLVDIIL EMNEGSLEGKIVTIGCGDNLHDCEILKDEVNKRIKARRVLFTRGGVSICSHTGPDILA ISCSN" gene 15726..17837 /gene="comR" /locus_tag="comR" /db_xref="1385725..1387836" CDS 15726..17837 /gene="comR" /product="polynucleotide phosphorylase/polyadenylase" /translation="MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNT TKSAKPRDGIDFFPLSVDYEEKLYSVGKIPGGFLKREGKPSEKAILTSRLIDRPIRPL FPKGFRNDVQVVATVLSVDQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGA FVVNPNAEQREKSSMHLVVSGTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEF IEGIVAEVGKEKMPVELYHAGEEITQLVREFATDKMKKAVQTFEKLERMENMDRVKEE TLAHFEETLEDFEDFVGDIEEVLQDIIKEEVRKLIVHENVRPDNRKLEEIRPIWCETG MIPRAHGSAIFTRGQTQVLNVATLGALGDVQKLDGLDEEENKRYMHHYNFPAYSVGEA RPSRGPGRREIGHGALAERALLPVIPSQEEFPYAIRLVSEVLSSNGSTSQASVCGSTL SLLDAGVPIKDMVAGIAMGLIKHDGKVAVLSDIQGMEDHLGDMDFKVAGTEYGITAIQ MDIKIDGIDKEILQRALKQAKEGRIHILGEMRKTISQPKPELSPYAPKIVKMQINPDK IKDVIGPGGKIITKIIDETGVKIDIEQTGEVFISGIEIDMIKKAQELINNIVVEPEVG KTYKGKVSRIMNFGAFVEILPGKEGLLHISHIAHERVAKVEDVLNIGDEVEVKVTEID EKGRVNLSRKVLLPKPEHKNK" ORIGIN 1 tcgtataatt atattaaaat tgttttagtg tataagaagg gcgggggaag tacgtgaaga 61 aaaaagcagc tttagcaaca ttggctatgt tacccttagg tgtggtaaat gcacatgctg 121 atggagatat aggtatagtg actataaatt atttaaatgt aagaaatgag ccaactgccg 181 aaagtagcat agcctttgtt gctaaaaaag atgataaagt tttgattaaa gactcttcta 241 atggatggta taaaataaaa gctgaatctg gacaagaagg ttgggcttca tcaaaatata 301 tagcaaaatc aaatagtgac tctttaagaa cgtctacaaa taaagaaaaa caagttattt 361 caaatagttt aaatatgaga aatggagcag gtacaagtta cagagtaata actgtactaa 421 aaaaaggtca aaaagtagaa gtaatatcag agagtaatgg atggtctaaa atcaaatatg 481 atggaagact aggatatgta tctagctctt atttaggaga cgtttcaaat tcaactaata 541 aatcaaaaac taaacaagtg aatacaactt cactaaatgt aaggagtgga ccaaatacaa 601 gttatggttt gttaggcaag ttgccaaaag gaagtaaagt agaagtaata tcagaaagta 661 atggatggtc caaaataaag tataatggaa aagatgccta tatatctagt atgtacttat 721 cggatgtaag tcaaagtaat tcagacaatt ctagtcaaag caatgataaa aagaatactg 781 ataaggttgt aaatacagct tctttaaatg taagaagtgg accaggttct acatatagta 841 agttgggaaa agtttataaa ggaagtaaag taactgtact atcagaaagt agtggatggg 901 ctaagattaa ttttaacaat aaagaagcat ttgtagtagg caattattta tctacttcag 961 cagatacttc aaataataac tcaaatagta actctgataa cagttctaat agtaatggca 1021 ataattcttc atcatcaggt caagtaaatg gtatgtcagg tataagtggg gctaaaattg 1081 attataaatc tttgagttat actttagaat ctcatataag taaacaagtt gagaaagcag 1141 catcaggagg aaatgtgata gctccaagta ataggaaaag cactccaagt cctgaattta 1201 gtactttttc agctcaaaga acaagctcat ttgtaaatgc aagttcaagt gatatagaat 1261 attatttaaa tcctaaaaat tttacaaata ctactaaagg tatgatgcag tttttaaaga 1321 ttaacagtta tagagatggt atttcagaat caagtcttaa ctcgtatctt aatggtttat 1381 cttctagtgt atttaaaaac cagggagcag cctttataaa tgctgccaag aagtataata 1441 tagatgttgt atatctagta tctcatgcta tgtgggaaac tgcttatggt aagtctacac 1501 ttgcccaagg tcaaacatta acatcttata agggacaacc tcttagtaag ccagttaaag 1561 tatacaattt ttttggtata ggagcaatag ataaaagtgc taatgtttca ggtgcagaag 1621 cagcgtattc caatggctgg actagtgtag aagctacaat agatggctct gcaaagtgga 1681 tatcacaaaa ttacgtaaat agttctaagt acaatcagaa tactatctac aagatgaagt 1741 ggaattatga ttatacatgg catcagtatg caactgatgt aaactgggct aatggaattt 1801 ctggaattat ggaaaattta attggtcttt atggaggagg aagtagtttg gtttttgaag 1861 ttcctcaata taagtaatac ataaataaaa aatatagact atgggtagtt ttcattttat 1921 ttaaattatc tatagtcttt ttgtatataa tttataatct gtaaatttaa tgttaacaaa 1981 acttttatgt tataatatta attctaagta aatataagtg agtaataggt agaaatagat 2041 aaaaagtggt aataatatat ataaagataa ttttgagaaa ggaggatata tatggaaagt 2101 attaaggaat atttggataa gttagaaatt aataatagtg gtcttggaaa gcaacttaaa 2161 gaagtttata taaatagagt agtttatttt aaggaagata agatagttta tttttatcta 2221 acttctaaag atattgtttc tcatgaactt ttagataaat ttaaagaaga attgatgtat 2281 aaactcgatt attttaaaga tatgaggatg aagataagat ttactggtct tgaaagaaaa 2341 tccaataaag atgttataaa aaaatattgg aataatatat tgtatatatt aaagtatctt 2401 tgtccatcta ttgcagggtg gtataaacaa gtagaatttc tttgtttaga agaagaatta 2461 aaaataaaac ttccaaaagg tatattttat gagcgattaa tgaaaaaaaa tgtaacttat 2521 gtacttaaaa ccgtgcttag cgaagagttg ggattagatt taaatataac aatagaaaaa 2581 gctgttgatg aaaaggtaaa taaagaaaga ctcataagaa tcaatgatag agaaatggaa 2641 gaaaaaatta gggctttaga aattggaaaa gttaataact gtgaagaaaa tgaagaggaa 2701 agctatgtca ttaagtctga tgtagatgaa aatttaatct atggagataa tgcaaatgct 2761 atgattgaaa atatagttga attaaatgca tcttctggaa cagttgcagt tgttggagat 2821 atatttgatg ttgacactaa agaacttaaa aacggaaaaa tacttatgat agcttcaatt 2881 acagattata ctagctcaat aagctgtaaa ctttttttaa cagatacaaa taaggatgga 2941 gtacttgaaa atgttaaaaa gggagcatac ttaaaaatca agggtgacat agtttatgat 3001 acatatcaaa gagaaattag tatgatgatt agtgggataa gaaaagaaac tagaatagag 3061 agagaagata aatcagagga aaaaagggta gaactccatg cacatacaca aatgtcttct 3121 atggatgcta tttgttctgt taaaaagctt gtagagcgtg cagccaaatg gggtcattct 3181 gctattgcta taacagacca tggtgttgta caaggatttc cagatgctat gaatgcaggt 3241 aagtcaaata atataaaaat actttatgga gtagaagggt acttggttga agatgattct 3301 ctcattatag aggatgcaaa tgataaagaa ctttcgcaga catttgttgt atttgacata 3361 gagacaactg gtttttctaa tacaaatgat aaaataactg agattggtgc tgtaaaaata 3421 gaaaacttta agattgtaga tagatttagt gagttaataa atcctgaaaa agatatttcc 3481 tataagatac aggaattgac aggaataact aatgaattaa ttaaagacaa gccaaccatt 3541 gaagaaattc ttcctaagtt tatggaattt gttggagata gtgtattagt agcacataat 3601 gcagagtttg ataccggatt tatatcgcaa aaatgtaggg aacaaggctt gttatataat 3661 aacaaaaaag tagatacact tatgttagca agagtaatgt tgccaaactt aaaaagacat 3721 agattaaatg tcgttgcaaa agaacttggt attcctcttt taaatcacca tagagcagtg 3781 gatgatgctg aggctacagc acttatattt aataagtttt tgcagatgct tacagaaaaa 3841 ggtgcaaaaa ctctaagtga tgtaaacaat atacttggaa agattgatta cacaaagctt 3901 agcacaaatc atataacctt gatagcaaaa aattctatag gtataaaaaa tttatataaa 3961 ataatttcag atgcacatgt aaatcatttt tttagagcac caagaatcct tagaagtgta 4021 ttaaatgaat ataaagaagg attaataatt ggttcggctt gtgaagctgg ggtggttttt 4081 caagctgtaa agaaaaacgt gtctgatgag gaaatgaaaa aaataataga tttatacgat 4141 tatattgaag taatgcctat agataataat agatttatga ttgataaagg agaagtaaag 4201 gatgaagaag agttaaggga gttgaatagg aaattaattg atacagccaa aaaatttgac 4261 aaaattccag tagctactgg ggatgttcat tttttagaca aacatgaagc tgtcttaaga 4321 aaagttctta aatattctca aggttttaaa gtagatgaag aagaaactta tttacatttt 4381 agaacaacag atgaaatgtt ggaagagttt agttatcttg gagaagaatt ggcatatgaa 4441 gttgtagttg aaaatagtaa tctgattgcc gatatggttg aagatataaa acctatacca 4501 gatgatactt atcctccaat tatagagggc tcagatgtgg agttaagaga aatgtgttac 4561 aaaaaagcca aacgaatcta tggagaccca ataccagaaa tagttcaaaa aagactggat 4621 agagaattaa attcaataat aagcaatggg tatgcagtta tgtatattat agctcaaaaa 4681 ctggttgcaa aatctctttc agatggatat ttagttggtt caagaggctc agttggctca 4741 tcttttgcag ctactatgag tgatataaca gaagttaatc ctcttccagc acattatatt 4801 tgtgaaaacg aagactgtaa atattcattc ttttatgaaa taggtgaatg gggctcaggt 4861 gttgatttac cagacaagga ttgtccaaag tgtggaagaa aacttgctaa aaacggtcat 4921 gatattccat ttgaggtttt cttaggtttt gaaggtgata aggaaccaga tatagactta 4981 aatttctcag gaaattatca gccaacaatt cataaataca cagaagaact atttggagag 5041 gggtatgtat atagggctgg gactataggt actgtagcag aaaaaacagc ttttggatac 5101 gcaagaaaat atgtggaaga aaataatata agtgtaccaa atgcagaagt acttaggctt 5161 tcaaatggat gtactggagt aaaaagaacc tcaggacaac atcctggtgg agttatggtt 5221 ataccagact ataaagatgt atacgatttt acacctatac agtatccagc aaatgatact 5281 tcttgtggtg ttataactac tcactttgat tatcattcaa taagtggtag aatacttaaa 5341 cttgatatac ttggacacga cggtcctacc attataagga tgcttgaaga tatgactgga 5401 ataaatataa cagaaattcc tttagatgat aaagagacta tgtctctatt tacatctaca 5461 gaagcattag gtgttacacc agaagaaata aactgtccta taggttgcct tgctgtacca 5521 gagtttggaa ctaagtttgt acgacagatg ttacttgaca ccaaacccac tacatttgca 5581 gaacttgtgc gtatatctgg tctctctcat gggacagatg tttgggtaaa taatgcacaa 5641 gacttagtta gagaagatat agttggatta aaagatgtta tatctacacg agatgacata 5701 atgaactatt taatatttaa aggattacct cccaaaatga gttttacaat aatggagagc 5761 gtaagaaaag gtaaaggtct aaaaccagaa cacattgaag aaatgaaaaa aaataatgtt 5821 ccagaatggt atataggctc atgtaaaaag attaagtaca tgttcccaaa agcacatgct 5881 gttgcttatg taatgacatc atttagaatt gcatattgta aagttcacta tccagaagca 5941 ttttatgcga cttattttac gacaaaagtt gaggattttg atgcagattt aattgttaaa 6001 ggattagatg ctataaaatc aaaaataaat gaaattgagt cactgggaaa tgatgcaacc 6061 acaaaagaaa aaggtatgtt gaccgtttta gaagttgctc ttgaaatgta tgctagagga 6121 ataaaattat taccagttga tatatataaa tcagatgcaa ctgagtttat agttgtagga 6181 gaaaaaacat tacttccacc aatggcagca atacaagggc ttggaggaaa tgcggctata 6241 aacatccaaa atgaaagaaa aaatggtgaa tttatatcaa aagaagattt gagaaagaga 6301 acaaaaatat caaaaacggt aatagaaact cttactaatc atggttcact tgagaatatg 6361 agtgagagaa atcaattgtc attgttttaa gttagcccaa aaagttgcaa ataaaagaat 6421 tttatgatat catagtatag aaaatagtat actttgcaga aactaagagt gagacagctg 6481 ttctcactct tttattttaa atatattatt aaaaagttgg tttattttta ttaaatatat 6541 tttatttaag attatataaa ctaatcattt acaattgaat aggaggaact ttaatgaaaa 6601 aaaatttaga agctacaatt gaggagattg taactaaaat aacggatgaa catggatttg 6661 aaatggttga tgttgaatat gtaaaagaag caggagaata ctacttaaga gtatacatag 6721 ataaagaaga aggaatatct ttaaatgaat gtgaattagt tagtagagaa ttaagtccaa 6781 tactagatga aaaagaccct ataaaagaaa attacttttt agaggtatct tctccaggac 6841 ttgatagagc attaaaaaaa gacagagatt ttgttagata tcaaggtaga gatgtagatt 6901 taaaattata taaaccatta aatggatgta agcaatttga aggtgaactt gtaggattaa 6961 cagaagataa taatataaaa atcattgcaa atggtaagga aatggaattt aatagaaaag 7021 atgttgctat tgtcagatta gcaataaagt tttagtggta tattaaatag ggaggatata 7081 aaaaatgaat catgaattta tggaagcatt agatgaatta gtagttgaca gaggtataga 7141 taaagaaata cttatagata ctatagaaca agctctttta actgcataca agaaaaactt 7201 tggttcagca caaaatgtta gagttgaatt tgatagagac aagggagata taaaagtatt 7261 ttctcaaaga gttgttgttg atgaatcaga tttatatgat actttcttag aaatagagtt 7321 agcggatgct agagagataa accctaatta tgaattaggt gatattatag aacatgaagt 7381 tacacctaaa aactttggaa gaattgcagc tcaaacagca aagcaagtag ttgttcaaag 7441 aataagggaa gctgagagag aaatagtgta taatgaattt atagaaaaag aaaatgaaat 7501 agttacagga gaggttgcta gagcaaataa aaatgttgtt tatgtaaatc ttggaagaat 7561 agaaggtata atgactcaaa gtgaacaaat accatttgag aattataaag caggtcaaaa 7621 aataaaattc tatatacttg aagttaaaaa gactaacaaa ggacctcaaa tagttgtatc 7681 aagaagtcat ccgggtctag taaagagatt gtttgaagaa gaagttcctg aaatatatga 7741 aggaatagtt caaataaaat ctgtagcaag agaagcaggg tcaagaacta aaatggcagt 7801 aaaatctata gatgaaaaaa tagacccaat tggagcttgt gttggaccaa aaggacttag 7861 agtaaaaaat atagtggatg aacttggcga tgagaaaata gatataataa aatatagtga 7921 agacccagca gagtttatat cagcagcact tagcccatca aaagttgtta gagtagatat 7981 agatgaagat gaaaagtctg ccttagtaat cgttccagat tatcagttat cgcttgctat 8041 aggtaaagaa ggtcaaaatg caagactagc agcaaaattg actaactgga aaatagatat 8101 taagagcgaa tctcaagcag aacaagaaat gttaaatctt gaaaattcca aagaaataga 8161 agctgaggat gttgaagctg aatttatcga ccaagaagag ttaggtactt cagaggataa 8221 ttttagtgaa gaagagtaag gagggatgat tttgaaaaaa gtaaaaaaag tgcctcaaag 8281 aaaatgcata gcatgtcaag atagagactc taaaaaagag cttataagaa tagttaaaaa 8341 taaagaagga aaaatatttt tagacccaac aggaagagcc aatggaagag gagcatatgt 8401 atgtaaaagc tctgaatgtc taaaaaaagc tataaagagt aaagcattaa ataaagcttt 8461 taaaatagat gttccagatg aagtctatga taatctactt atggagttag aagaatatga 8521 aaaataataa agaaaaagta ctttcgttct tagggctcgc aactcgtgca gggaaaatag 8581 tgtctggtga tgattcaact ttgcttgacc ttaaaaaagg aaaagtaaat ttgattttaa 8641 tcgcagaaga tgcatcaaat aatactaaaa aactttttaa agataaatca acttttagaa 8701 atattccata tctatttttt tcaacaaaag aggaaatagg atttgcaata ggaaaatctc 8761 caagagcagt tgtaggaata aaagatgaaa atttttctaa aaagataatt gaactaatag 8821 aaatttaaaa taaaataggg ggtgatcttg tgtcaaaaac aagagtatac caaatagcag 8881 aagaattaaa tatatcaaat gaagagctta taaataagtt agctgaatta gatataaatg 8941 taactgacaa agattcagta ttagaaggtg aagagttaga attagcactt gaaatgttag 9001 gtgaagattt atctcaagaa aatggaaatg ttatagaaat agatggaaag ttgacagtac 9061 aagtattagc aacgaaatta gataaatctc catcagaaat aattatgaag cttatgaaaa 9121 tgggaactat ggcaacaata aatcaagaga taagttttga gattgctgct ttggctgcca 9181 aagactatgg atttgaatta acagtagctg aaagtgatga tacagaagct ttagaaatag 9241 aagctttaat ggaaattgaa gaagataaag aagaggattt aaaacctaga ccaccagttg 9301 ttacagttat gggacatgtt gaccatggta agacatcttt actagatgca ataagaaaaa 9361 ctgatgtgat ttcaggtgaa gctggaggaa taactcagca tataggtgct tcagaagtta 9421 aaatcaatgg acacaaaata gtatttttag atactccagg acatgaggct ttcacatcaa 9481 tgagagcaag aggagcacaa gttacagata tagcaatatt agtagttgca gcagatgatg 9541 gtataatgcc tcaaacagtt gaagctataa accatgctaa agcagcaggt gtacctttaa 9601 tagttgctat taataaaata gataaaccag gtgcaaaccc agataaggtt aaacaggaat 9661 tagcagacca aggattatta gttgaagact ggggtggaga agtaatagca gttccagtat 9721 cagctaagaa aaaagaagga atagatacac ttttagaaat ggtattattg gttgctgaaa 9781 tggaagagtt aagagctaat ccaaataaaa gagcagtagg aactgttata gaagctgagc 9841 ttgataaagg aagagggcca gttgcaacag tacttgttca aggtggtact ttaacagtag 9901 gtgacccaat cgttgcaggt gttgcatgtg gtaaagttag agcaatgata aatgcaaaag 9961 gtaagagagt aaaaacagca ggaccatcta cagcagttga gatattaggt ctatcagaag 10021 ttccacaagg aggagaccaa tttgtcgaag ttccaactga taagattgct agaagtgtag 10081 cagcaagaag acaacaaata gttagagatg aaatgttaaa atcaactcaa agattatcac 10141 tagatgctct atttagtcaa atgagtgaag gttctataaa agaccttaat atagttataa 10201 aagcagatgt acaaggttca gtacaggcag ttaaacaatc tttagaaaaa ttatcaaatg 10261 aagaagttca agttaaagta atacatggtg gtgttggagc tgtaacagaa tcagacatat 10321 tacttgcagc agcttctaac gcaataataa taggattcaa tgtaagacca gttccaggtg 10381 cagaatctct aggagaaaaa gaaaatgttg atataagaac atatactata atatacaagg 10441 caatagaaga tatacaagcg gctatgactg gtatgttaga ccctgaatat gttgatgaag 10501 aaacaggaaa agctgaaata agagaaatat ataaaatatc tggtgttgga acagtagctg 10561 gatgttatgt gactaatggt aagatattta gaaattgtaa agtaagatta gttagagata 10621 gcataataat acatgaaggt gagcttgcag cacttaagag atttaaagat gatgtaaaag 10681 aagttaattc tggatacgaa tgtggtatga gttttgtaaa ttataacgac ataaaagaag 10741 gcgatatagt agaagcttat ataactaaag aagtagaaag aaaattataa attcgtatca 10801 aagaaaatca gttagtaaag aaggtcgatg gtatggcatc atataataga acaagaagga 10861 tagcagaaga aataagaaaa gtcgtaagta ctatgcttat aaatggagta aaagacccta 10921 gaataacatc tatggtgagt gtaactgatg tagaagttac aaatgaccta agatatgctt 10981 atgtatatgt aagtattcta ggtggagatg aagaatccac actaacaggt cttaaaagtg 11041 ctggaggata tataagaaga gaagtaggaa aaaatataaa acttagatat attcctgaga 11101 tagtatttaa acttgatgat tcaatagaaa aaggaatgta tatggataac cttataaaaa 11161 gagttaatga aaaaaatgct caacaaaatg aggatgaaaa ttatgatgaa taatatggat 11221 agtattataa actatattta tgagggtgac tattttatag ttacctctca tatcagtcca 11281 gatggagaca atgttggttc tacactttca atgtattata cattgaagaa tttaggaaaa 11341 aatgtatatt atgtacttga tgatgaagct ccattaaatt taaggttttt ggttgaaggt 11401 gtaaaaatct ataagtctaa tgaatttaat atgaagaact attctttaat tgcacttgat 11461 tgtggggata agatgagaat atgtgtgagt gatgaaatca aaaataatgc atcaaaatta 11521 atctgtattg accatcatgc tagtaatgat tcatatggag atttaaatta tgtagatatt 11581 gatgcatctt ctacatgtga actagtttat aatttattgg ttagatttca gcaaacaaaa 11641 gatattaata ttataaatga agatatagca acatgtttat atacaggtct tgtaactgat 11701 actggaaact tttcgtattc aaatgtacat gcaagtagtt ttgaaatggc aaaaaattta 11761 cttgttttag gtgcacaaaa aaatactata atacaaaata tatatcaaag caattcttct 11821 gattattata aattattagg agaagctcta aaaggtttgg agatatttga ttcaaaggta 11881 tctagtatag ttttaactca agacatgatg aatagaaata atattagctt taatgatgtt 11941 gatggaataa caacatatac aagagatata aaaggtatag aagttggaat tttatttaaa 12001 gagaaaaaac aaaatgaaat taaagtgagt tttaggtcaa aaaattatgt tgatgtaagt 12061 gaaatagcca agttatttgg cggtggtggt catgtaaggg ctgctggatg tactattaga 12121 gatagtattg ataatgcaaa gaaaatggta ctagaggcag tgttaaaatc aatttaaggt 12181 gacagtaaaa tgaataagat tataagtata ttgaaaccca caggtatgac atctcatgat 12241 gttgtaagta gagtgagaaa gattttaaat ataaaaaaag ttggtcatac aggtactctt 12301 gacccagatg cttcaggtgt tttaccaatc tgtataggga aagctacaaa agtatgtgaa 12361 gttattttaa acaaagataa atcgtatata tgtgagctta ctttaggtat aagtacagat 12421 acttatgatg cttcaggtga aattttaaaa aaagttgatg attttaaatt tagtaatgaa 12481 gacatagaaa gagcttttga tacacaaaga ggagagataa atcaacttcc tccaatttat 12541 tcagctttaa aggtaaatgg aaagagaatg tgtgatttag taagaagtgg tagacaatct 12601 gaaattactt taaaaacaag aagagtaaat ataaaagaca taaaaatact aagtataaaa 12661 ggtaataaag taatgtttta tgttgagtgt tctaaaggga cttatgtgag aagtatttgc 12721 catgatatag gagaatatct gggttgtgga gctcatatgt cgtttttgaa tagaacatct 12781 tctggtaaat ttgacttaga taattcaata acattagaag aattagaatt attttatgaa 12841 aataaaactt tagacaaata cttatatgat atagattatg tccttgattc gtttaattat 12901 gttgtattaa accctaatgc tataaaatat tatagtaatg gtggctcaat agatgataaa 12961 aggtttttaa aaaataattt cgataaagat gatgaagttg taagagtata cagtacagat 13021 aatttcttag gattaggaaa gttatcaaaa cacaataata caataagtgt taaaagtgat 13081 aagatgttca tataaccaat gtatttaaaa aaacaacaaa agagatagta ctataataac 13141 ttctatagtc tatctctttt acttatgcta taatagtttg tgaataagtt aagagtaaat 13201 tatattttag cggggaacat ttattatggt gattataaaa tctataaaag aaatagcaaa 13261 cataaaagaa agtgtcatta ccataggaaa ttttgatggt gtacacaaag gacatcaagt 13321 tcttatagga aaaacagttg aatatgcaaa aaaagaaaat atacagagta ttgtatttac 13381 atttgcaaat catcctgtaa attactttag accaaactca acaaaaaata ttataagcaa 13441 tgatgataaa ataaaattat tagaagattt gggaatagat atagttgtaa tcataccatt 13501 tgatgagtat atgactaaaa tacctgcaaa ggatttcgta gatgagatac tagtaaaaaa 13561 attaaaagct aaaaagatag taattggaca tgactttaca tttgcaaggg caaaagaagg 13621 caatgttaat ctattaaaaa gcttagaaca tgaatttggt tttgaggtag aagtaataaa 13681 acccatcaaa atcaatgatg taagagtgag tagtacttat attagaagtt tagtatccca 13741 gggtgatatg gctaatgtca aggaatattt gggtagaaat tacaagttag aaggttgtgt 13801 tatacattct aaacaccttg gaagaactat aggattccca acggcaaata ttgaccttaa 13861 gaataatatg ctcgttccaa agagaggtat ttatgcttct attgtacata ttggagatga 13921 gacttatttt ggtgctacaa atgtaggcta taacccaaca gttaatggaa aaactttgtc 13981 tattgaaaca aatattttag agtttgatag agatatttat ggggaaaata taattgttga 14041 atttttggaa agaataagag atgaaagaaa gtttaattca atagatgact taaaaaatca 14101 attgtataat gatacaaatt atgtgtatga aaactatgtt tgcaaaaaca agtaatgtat 14161 gataaaatga ttaaggaaaa taaccattac tcggcatttg aatactccaa tcaatgctta 14221 gtaataggcg tttctaaaaa aatacggagg taatctaaat gataaacaaa tcagaaataa 14281 taaaagaata tggaagagct gaaggggata ctggttctcc agaagtacaa atagctttat 14341 taacagctag aataaacgag ttaaatggac atttaaaaac tcataagaaa gaccaccatt 14401 caagaagagg actattaaaa atggttggta gaagaagaaa cttattagct tacttaaagg 14461 aaaaagatct tgaaggatat agagcattaa tagctaaatt aggattaaga aagtaatttc 14521 attctttata aaaaagcagg tatagtgtat acctgctttt ttatagttaa ttcattataa 14581 agtaaaatag ttaataataa aagtagttta tatgttataa aaaattataa aatgaataat 14641 attgggtaag aatattaaaa tagtatacaa atacataatc aatttaaaag gaaagacagg 14701 ataaatatag aaattttata acaggataat tagttggaat aaggaggata ttattttgaa 14761 aataaagtta gtatgcgata gtttgtgcga tattccagat gaaatatcag aaaaagatta 14821 tatagagata gttccactta cagttatttt taatgatagg gaatatatag aaggagtaga 14881 tataaagaaa gaagagtttt ataaaaaagt aaaagaaatc aagcaaatac ctaaaacttc 14941 acaagctaca tatatggagt ttaaagaagt gtttgataag ttcataacag aaggttatca 15001 tataatctgt atgacagggg ctgcaaacgc atcaggaact tttcaaagtg ctatgatagc 15061 taaaaatgat gtaaatgaaa atgaaaaaat acatatattt gatactagaa atttatctct 15121 aggtagtgga caatatgtta taaaggcatg tgaacttctt gaagaaggac tgggatttga 15181 agaaattata gatgaattag aaaatactcg cagtagtgta agattacttt ttgcaccata 15241 tacacttgat tttttaaagc agagtggaag agttccagtt gcaactgctt tgataggaaa 15301 tatgttaaat ataaagccta tatttttctt tgataatggg gaagctaagt tggtaaataa 15361 ggttagagga ataaagaata tagcaagtaa actggtcgat ataattttag aaatgaatga 15421 agggtcttta gaaggaaaaa tcgtcacaat aggttgtgga gataatttac acgattgtga 15481 aatattaaaa gatgaagtaa ataaaagaat aaaagcaaga agagtattat ttactcgagg 15541 aggagtttct atttgctctc atacagggcc agatatattg gctataagtt gttctaatta 15601 gtagtaatat aaggtttttg catatatatg tgaagataat tttatattgt taatttatag 15661 tatttttgat aatatagtaa atagagtgat atacgtgttt tttaataaga ggaggacaag 15721 cattaatgtt tgaacataaa atatttaaaa tggattttgc aggaagagaa ctttctgtag 15781 aaataggaaa gatttgtgaa atggctagtg gtagttgtat agttcgatac agtgacagta 15841 tggtaatggt aaatacaact aaatcagcca aacctagaga cggaatagac ttttttcctt 15901 taagtgtgga ttatgaagaa aaattatact ctgtaggtaa gatacctgga ggttttttaa 15961 agagagaagg gaagccttca gaaaaagcta tacttacatc aagattgata gatagaccaa 16021 taagaccttt attcccaaaa ggatttagaa atgatgttca ggtagttgca acagttctat 16081 cagtagacca agattgtaca ccagatatag tagcaatgat aggttcttca atagcccttt 16141 ctatatcaga cataccattt aatggaccaa caggttcagt atgtgttggc cttgtagatg 16201 gtgcatttgt tgtaaatcca aacgcagagc aaagagaaaa aagttcaatg catctagttg 16261 tttcaggtac aaaggaagca ataatgatgg ttgaagccgg agctgatgaa gttccagatg 16321 aggtaatgct tgatgctatt ttatttgctc accaagaaat aaaaaaaata gttgagttta 16381 tagaaggtat agttgcagaa gttggaaaag aaaaaatgcc tgttgaatta taccatgcag 16441 gagaagaaat aactcaattg gttcgcgaat ttgcaactga taagatgaaa aaagcagttc 16501 agacttttga aaagttagag agaatggaaa atatggatag agttaaagaa gaaactttag 16561 ctcactttga agaaacttta gaagattttg aagattttgt tggagatata gaagaagtat 16621 tacaagatat aataaaagaa gaagtaagaa aacttatagt acatgaaaat gtaagaccag 16681 ataatagaaa acttgaagaa ataagaccta tatggtgtga aactggcatg atacctagag 16741 ctcatggttc agccatattt actagaggac aaactcaagt acttaatgtt gctactttag 16801 gtgctttagg agatgttcaa aaattagatg ggttagatga agaagaaaac aagagatata 16861 tgcatcatta taatttcccc gcatatagtg ttggagaagc tagaccatca agaggaccag 16921 gaagaagaga aataggacat ggtgctttag cagaaagagc tttattacca gtaataccat 16981 ctcaagaaga atttccttat gctattagat tagtttctga agtattaagt tcaaatggtt 17041 ctacatctca agcaagtgta tgtggctcaa cattatcttt acttgatgca ggtgtaccta 17101 taaaagatat ggttgcaggt atagcaatgg gacttataaa gcatgatggt aaggttgcag 17161 tgctttcaga tatacaaggt atggaagacc atttaggcga tatggacttt aaagtagctg 17221 gaacagagta tggtataaca gcaatacaaa tggatataaa aattgatggt atagataaag 17281 aaattctaca acgtgcttta aaacaagcta aagagggtag aatccatata ctaggagaga 17341 tgagaaaaac tatatctcag ccaaaaccag aactttcacc atatgcacct aagattgtta 17401 aaatgcaaat aaatcctgac aagataaaag atgtaatagg gcctggtgga aagataataa 17461 ctaagataat agacgaaact ggagttaaga tagatattga acaaactggg gaagtattta 17521 tatcaggtat tgagattgat atgattaaga aagctcaaga acttataaat aatatagtag 17581 ttgaaccaga agtaggaaaa acttataaag gtaaggtaag tagaataatg aactttggag 17641 catttgttga aatacttcca ggaaaagaag gattacttca tatatctcat atagctcatg 17701 aaagagttgc caaagttgaa gatgtattga atatagggga tgaagttgaa gttaaagtta 17761 cagagattga tgaaaaagga agagttaatt tatcaagaaa agttctttta ccaaaaccag 17821 aacataaaaa taaataactt attatataat taaaagcaaa gtcttaggat tttgcttttt 17881 taaatacaaa aaagtagata attttaaaat gatagttatg gatggcttat agttcttttt 17941 ctgtaaggct ttactcttat aaagaagcta tttaaaagct gattaataga aagctttatt 18001 gatatatata gaatcactta agttatattt agtgcataaa cagagcttat ttttaatagt 18061 attaaataag aaacaatttg tacataatta gggggagttt //