LOCUS NC_012658:1 19402 bp DNA linear BCT 04-SEP-2013 DEFINITION Clostridium botulinum Ba4 str. 657 chromosome, complete genome. ACCESSION NC_012658 SOURCE Clostridium botulinum Ba4 str. 657 chromosome, complete genome. COMMENT locus start: 1; locus end: 19402 COMMENT n1_4mer:GRV/n1_4mer:RV = 6.311786; n0_4mer:D = 22.671884; n0_4mer:PS = 44.161661 FEATURES Location/Qualifiers source 1..19402 /organism="Clostridium botulinum Ba4 str. 657 chromosome, complete genome." gene 164..1510 /gene="dnaA" /locus_tag="dnaA" /db_xref="164..1510" CDS 164..1510 /gene="dnaA" /product="chromosomal replication initiation protein" /translation="MSTHLTETWEKAINIIKGELTEVSFNTWIKSINPISLENNSFKL AVPNDFTKGILESRYKDLIVNALKLLTSKKYNIDFIVTTEEKIEENEKNHNNEKSNIV VNDEMSTMLNPKYTFDSFVIGNSNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYILHNNPKSQVVYVSSEKFTNELINSIKDDKNVEFRNKYRNIDILLVDDIQF IAGKERTQEEFFHTFNALYEANKQIIISSDRPPKEIPTLEDRLRSRFEWGLIADIQAP DFETRMAILKKKADVEKLNIPNEVMVYIATKIKSNIRELEGALIRIVAFSSLTNKEIS VDLASEALKDIISSKQTRQVTIDIIQEVVANYYNLKIEDLKSARRTRNIAFPRQIAMY LSRKLTDMSLPKIGEEFGGRDHTTVIHAYEKISNNLKKDESLQNAINELNKRINQK" gene 1773..2876 /gene="dnaN_1" /locus_tag="dnaN_1" /db_xref="1773..2876" CDS 1773..2876 /gene="dnaN_1" /product="DNA polymerase III subunit beta" /translation="MKITCQKNILLEGISIVQKAVTGKSTLPILSGILIRANKDELIL TGSDMDLSIETKVKANILQEGTIVLDARLFGEIIRKLPNDLIEINTLEDNSIEIICQN SRFNLIYMNPDEFPNPPIINENMIFSIDENKLKNMIKGTIFATAQDETRPILTGVLFQ IKDKMLNLVALDGYRLALRSEVVDNDNTINAVIPGKTLNEVSKILEEDNENVNITFTP NHILFSIGETKIISRLLEGEFISYKSIIPEEYNLKIIAKRLELLNSIERASLMAKEGN TNLVKFDFSNDKIVITSNSQLGMVREELRVVLQGEDLQIAFNSKYLLDVLKTMEDDEV VLEFSSSVSPCIIKNTELNNCTYLVLPVRLNNN" gene 2896..3102 /gene="" /locus_tag="" /db_xref="2896..3102" CDS 2896..3102 /gene="" /product="S4 domain-containing protein" /translation="MIEVKINSEIIKLDSFLKWSGATTLGSEAKFFIQNGEVKVNGEI EKRRGRKLKIGDLIEFNNEMYKII" gene 3171..4265 /gene="recF" /locus_tag="recF" /db_xref="3171..4265" CDS 3171..4265 /gene="recF" /product="recombination protein F" /translation="MYIKNVHLINFRNYDDMYLELSPNTNIFVGNNAQGKTNILESIY YSSIGKSHRTNKDKDLIKWDKNNTYLRTYVSRERLDKTIDINIFKNGKKAITVNKIKI KKISELMGNLNVVMFSPEDLRIIKDSPGNRRKFLDIELCKINNVYYHDLVQYNKILSE RNTALKNWNNKINDIIDIYDEQLSKYGAFIIKERNKYLDKLNIIGKNIHKKITNDLED INFRYLTNIKDFDNAEKELLMFFKKNRKKDFERNSTSIGPHRDDFEVSINNIDTRIFG SQGQQRTAVLTLKFASLEIIKNIIGEYPVLLLDDVLSELDSNRQKFVLNSIDKIQTII TCTGIEEIDKYLDKKQSQLYLVNNGKIKRV" gene 4286..4549 /gene="" /locus_tag="" /db_xref="4286..4549" CDS 4286..4549 /gene="" /product="hypothetical protein" /translation="MFLHLGENVVVPIKDVIGIFDMETSMYSSDTIQFLRLAEEDGFV ERITKEKPKSFVIAEVDKKSKIYLSPISSATLTKRTKVLYNEL" gene 4567..6480 /gene="gyrB" /locus_tag="gyrB" /db_xref="4567..6480" CDS 4567..6480 /gene="gyrB" /product="DNA gyrase subunit B" /translation="MPQENKQVYDESQIQVLEGLEAVRKRPGMYIGSTSLRGLHHLVY EIVDNSIDEALAGFCTHIEVFIHKDNSITVVDDGRGMPVGMHSKVKKPAVEVIMTILH AGGKFGGGGYKVSGGLHGVGASVVNALSEHCNVEVRRDGHIWLQKYERGIPKTGLDIV GDTEKHGTKIYFKPDVEIFDELEFEYDTLAQRLRELAFLNKGIKISLTDERYDKQEMF HYEGGLRSFVLYLNRNKEKLHQQPIYVDKNKDGCIVEIAMQYNDGYAENIFSFANNID TIEGGTHLAGFKSALTRAINDYARKFNYLKDTDKNLSGDDVREGLTAVISVKLTDPQF EGQTKTKLGNSEVRGIVDTIVGESIGSFLEENPNVGKIIIEKGLSASRAREAAKRARE LTRRKSVLESTSLPGKLADCSSKDPSLCEIYLVEGDSAGGSAKQGRNREFQAILPLKG KIMNVEKQRLDKILASDEIRAMITAFGAGIGKEFNLEKIRYNRIIIMTDADVDGAHIR TLLLTFFYRYMKELVEEGHVYIAQPPLYRIYKAKKELYVYSDKELDEALLELGGKDTN TNIQRYKGLGEMDPEQLWETTMNPEHRTLLQVTIEDAMAADEIFTILMGTKVEPRRDF IENNADKVVNLDI" gene 6506..8986 /gene="gyrA" /locus_tag="gyrA" /db_xref="6506..8986" CDS 6506..8986 /gene="gyrA" /product="DNA gyrase subunit A" /translation="MLNEGKILPVDVSKEMKKCYIDYAMSVIAGRALPDVRDGLKPVH RRIIYSMQGLGLAPEKGYRKCARIVGDVLGKYHPHGDTAVYEALVRMAQDFSIRYTLV DGHGNFGSVDGDGAAAMRYTEAKMSKISMELIKDINKNTVDFIPNFDGEEEEPSVLPS RFPNLLVNGSAGIAVGMATNIPPHNLTEVIDGIIMLIENEDVSILDLMTKIKGPDFPT SGLIVGTRGIREAYETGRGKVIIRAKAEIEEEKGKNRIIVTEIPYQVNKSKLIENMAN LVKDKKINGISDIRDESDRQGMRIVIELKRDANPNIVLNQLYKHTKLQDTFGIIMLAL VNNQPQVLNLKEILVNYVEFQKEVIRRRTRFDLDKALARAHILEGLRIALDHIDEVIK LIRASKNTAEAKEGLMNNFNLSEKQAQAILDMKLQRLTGLEREKIEEEYKELMEKISY FREILDKEELVLSIIKEELIEIKNKYGDERKTEIVKGEHDIDIEDLIEDKKVIITLTH GGYIKRLDMDTYSSQKRGGKGIQATSTKQDDFIENMFVTSTHSIILFFTNRGKVYKLK AYEIPEAGRTAKGTNIVNLIPIENNEKIQTVIGLKDIDDMKHFVMCTRNGIIKKTEIK KYSSIRKGGLNAINLREDDELIDVKMTKGNNEIIIVTQNGYCIRFNEEDVRPMGRVAT GVKGITLREDDKAVSMEVVLEDEALLSISENGFGKRTDIEEYPIHRRGGKGVITYKIT DKTGPIVGARFVKEDDELMLVNSGDVAIRINVSEISKTSRNAMGVKLMRTSEEEKIVA IAKIKSEDIIEEEILNEENLNEENLNEE" gene 9402..10903 /gene="rrs_1" /locus_tag="rrs_1" /db_xref="9402..10903" gene 11125..14026 /gene="rrl_1" /locus_tag="rrl_1" /db_xref="11125..14026" gene 14119..14235 /gene="rrf_1" /locus_tag="rrf_1" /db_xref="14119..14235" CDS 14119..14235 /gene="rrf_1" /product="5S ribosomal RNA" /translation="SGDYGLKVTPVPMPNTKVKLQSADGTAGEALWKSKSLP" gene 14243..14321 /gene="" /locus_tag="" /db_xref="14243..14321" gene 14323..14400 /gene="" /locus_tag="" /db_xref="14323..14400" CDS 14323..14400 /gene="" /product="tRNA-Ala" /translation="WGYSSVGRAPALQAGGQEFESPYLH" gene 14562..15014 /gene="" /locus_tag="" /db_xref="14562..15014" CDS 14562..15014 /gene="" /product="hypothetical protein" /translation="MEYKDIVYINMHLDNEELKIFNKLSISEQKHSIKVAYDIEKLYE EGKYNLTKDEFIKVALLHDIGKLNYKVDIIKKSIIVIVDKITNSRIKKFQNIKSVYVH YNHPYLGYCILKQYNKYSEKMLYLIKNHHNENIINKELSLLIYSDNLN" gene 15030..15551 /gene="" /locus_tag="" /db_xref="15030..15551" CDS 15030..15551 /gene="" /product="transcriptional regulator, biotin repressor family" /translation="MNSMERRKNIEDMLMKNNKPIKGSEIGEKLGVTRQVIVKDIAIL RASGKNIIATPEGYLIPNENKQLIRKIIAVCHDSKDIKDELEIIIKFGGIVEDVVVEH PIYGEIKAMLMIKSMYDIGNFIKNIQNNKAEPLLILTGGIHLHTISSDNEDIMNKIIE ELNQKNYLVDEEI" gene 15553..16716 /gene="" /locus_tag="" /db_xref="15553..16716" CDS 15553..16716 /gene="" /product="iron-sulfur cluster-binding protein" /translation="MDKVALLKCDEYDLEKVEKTIRNGFELLGGNSFLNKLIPYNSKV LLKPNMLSIENEGSPVVTNSVVFEAVIRILRDYSSNISFGDSPGFGDSKRAAEKSGLL NIANKYNITFKDFKESINVSCDNSILCRSWTVAKAAYETDVLITLPKLKTHAMAYFTG AVKNQFGCIPGTLKATWHTRMPNANNFCKMLLDLNTLLETDFAILDGIIAMEGNGPKN GTPYNLNTIIMGDSLTAVDSVAVKIIGYDNPLEIPVLKEAYDSNWGSVFLKDIDVLGE KIDSMVVDNFKLCREGGDFYFINPKVTNFLKDIIAPDPTLIEEKCIGCNRCAEVCPEK PYVIDMIKKEGKKIPVWNMKKCIRCFCCQELCPKGAIETKYSFIGRFLNRDGR" gene 16721..19402 /gene="" /locus_tag="" /db_xref="16721..19402" CDS 16721..19402 /gene="" /product="hypothetical protein" /translation="MKNKKALFIPLFIIILFIAFFNKIINFIINIKWFKEVNYLTIYF TKMRAIIILMIPIFIIFFISIWMYYKSLMINKNKSIVDIGLNKNDYGKKLFFIFNFIA SIFLAYIFSSSYWYRILQFNNSVDFNVKDPIFFKDVSFYVFKLPLFESLYKVIISLLL FLVITTFIAYFILEAKYKIQSKKDINLKNINHGIKSFAGKQLAIVSGLIILFISFGHL IKIWNLVYSSNGVSFGASYTDVHATLLFYKIIVVITLISSIVTLLSIVKGKFKPVSIC IGITIFLIVSQNIASFLVQNFIVKSNEKTLEQPYIKNNIDLTRKAFALDDIEIRDFDI KNDLQKQDITDNKASIDNIRINSFKPTLEFYNQVQIIRYYYTFNDIDIDRYNINGKYN QVFLAAREIDTDALNPNTWQNRHLIYTHGFGAVMNKVNSVTSEGQPDFVIKDIPPYNK TNIKLTNPRIYFGEKTNDYVIVNTKINEFDYPKEDSNKTNKYNGHAGIKMSFINRLLF SINKKDINFLLSKDIKKDSKIIINRNIVERAKKIAPFLTYDSDPYMVIYNGKIYWIID AYTTTNRYPYSEPYDSINYIRNSAKVVIDSVDGDINFYITDKKDPIVNNYDKIFKGLF KEEKDAPKEIREHFRYPKDLFSIQSKVLGKYHVKDPGVFYNGEDLWEVSKDQKHVEGE TNTNDAPYIIMKLPDQNKEEMVLLNYFNVMKKDNMIALFGARMDGEQYGKKILYKLPS DKTVYSPYLFKQKINQDTNISKELSLWNREGSQVQYGDTIILPIKNSLLYIEPLYLRA SGKNSIPEMKRVILSYNDKLVLSPSIQEGIKEIFNSKDNKINDKNEKDSTKTIDDSKL KKAQEYYNKAIEAQKNGDWTKYGENINELGNILNSIK" ORIGIN 1 ttagtagtta atttttttgt ttttatgtaa ccataattat aaacatgtga atattttttt 61 caacaattgt caagttaata taaataatgt atataaagtt gtttatattt tgtttactat 121 atgtgaacat tctaagtttc tatcaagact ggaggattaa attatgagta cccaccttac 181 agaaacctgg gaaaaagcaa taaatattat aaaaggtgaa cttacagaag taagttttaa 241 tacatggatt aaaagtatta accctatttc tcttgaaaat aattcattta aactagctgt 301 accaaatgat tttacaaaag gaattcttga aagtaggtac aaagatctta tagttaatgc 361 gctaaaatta cttacctcta aaaaatataa tatagatttt attgtaacta ctgaagaaaa 421 aatagaggaa aatgaaaaaa atcataataa tgaaaaatct aatatagttg taaatgatga 481 aatgtctact atgttaaatc ctaaatatac ttttgattcg tttgtaatag gaaatagtaa 541 tagattcgct catgcagcat ctttagcagt agcagaagca cctgctaagg catataatcc 601 tttatttata tatggtggag ttggtcttgg taaaactcac ttaatgcatg ctatcggtca 661 ttatatattg cataacaatc ctaaatctca agtagtttat gtatcttctg agaaatttac 721 aaatgaatta attaattcta taaaagatga taaaaatgta gaatttagaa ataaatatag 781 aaatatagat attttattag ttgatgatat tcaatttatt gctggaaaag aaagaactca 841 agaggaattt ttccatactt ttaacgcact gtatgaagct aacaaacaaa taattatatc 901 aagcgatcgt cccccaaaag aaatacctac cttagaagat agattaagat ctagatttga 961 atggggactt atagctgata tccaagcacc tgattttgaa accaggatgg ctattttgaa 1021 gaaaaaagct gatgtagaaa aattaaatat tcctaatgaa gtaatggtat atatagctac 1081 aaaaattaaa tcaaatatcc gtgaattaga aggagcttta ataagaatag tagctttttc 1141 gtcacttact aataaagaaa taagtgtaga tttagcttct gaagcattga aagatataat 1201 ctcaagtaaa caaacaagac aagtcactat agatattatt caagaagttg tagcaaacta 1261 ttataatcta aaaatagaag atctaaaatc agctagaaga acaagaaata ttgctttccc 1321 tcgccaaata gctatgtacc tttctagaaa actaacggat atgtcattac ctaaaattgg 1381 tgaagaattt ggcggacgtg atcatactac agttatccat gcctatgaaa aaatatctaa 1441 taacttaaaa aaagatgaaa gtcttcaaaa tgcaataaac gaattaaata aacgaattaa 1501 tcaaaaataa aaataatata caaatgttta taataatatc ttatttattt gttgataatg 1561 tactaaatac caattaaaca tatttcctgt ggataagcac ttaattttaa tgttaactta 1621 tccacaatta ttttgttatg aaaaatgttg atattttagg ctttgtacga cttattcaca 1681 tatcaacaac ccctactact actactacta ttttattata ttatctattt ctattctaac 1741 aataagaatt gttaataaag gaggctaatt ttatgaaaat aacttgtcaa aaaaacattt 1801 tactagaagg tatatctata gttcaaaaag cagtaactgg aaaatcaact ttacctatat 1861 tatctggaat acttattaga gctaataaag atgaattgat tttaactgga tctgatatgg 1921 atcttagtat tgaaactaaa gtaaaagcta atattttaca agagggaact atagtcttgg 1981 atgctagact ttttggtgaa ataataagga aattaccgaa tgatctaata gaaataaata 2041 cattagaaga taattctata gaaataatat gtcaaaattc tagatttaat ctaatatata 2101 tgaatccaga tgaatttcct aatccaccta ttattaatga aaatatgatt ttttcaatag 2161 atgaaaataa attaaaaaat atgattaaag gaaccatatt tgctacagct caagatgaaa 2221 caagacctat tcttacaggt gttttgtttc aaataaaaga taaaatgtta aatttagtag 2281 ctttagatgg ttacaggtta gctttaagaa gtgaagttgt tgataatgat aataccataa 2341 atgctgttat tccaggaaaa acattaaatg aagtttcaaa aattttagaa gaagataatg 2401 aaaatgttaa tattacattt actcctaatc atattttatt tagtatagga gaaacaaaaa 2461 taatttctag attattggaa ggagaattta ttagctataa atctataata cctgaagaat 2521 ataatctaaa aataatagct aaaagattag aacttttaaa ttccatagaa agagcttctc 2581 ttatggctaa agaaggaaat actaatttag ttaaatttga tttttcaaat gataaaattg 2641 taataacatc aaattctcaa ttaggaatgg ttagagaaga attaagggta gtattgcaag 2701 gagaagattt gcaaattgca tttaactcaa aatatctttt agatgtgtta aaaactatgg 2761 aagatgatga ggttgtattg gaattttcaa gtagtgtaag tccttgtatt ataaaaaata 2821 cagaactaaa taattgtact tatttagttt tacctgtaag attaaacaat aattaattat 2881 aaagagggaa taaagatgat tgaagtaaaa attaattcag aaataataaa gttagactct 2941 tttttaaaat ggtcaggagc aacaacttta ggttcagagg ctaaattttt tatacaaaat 3001 ggagaagtta aagttaatgg agaaatagaa aaaagaagag gtagaaaact taaaatcgga 3061 gatttgatag agtttaataa tgaaatgtat aaaattattt aaatttttat ataaatttta 3121 aataattgtt actaaaaaat attatggtat aattaattta ggtgtttaga atgtatataa 3181 aaaatgtgca cttaataaat tttagaaatt atgatgatat gtatttagaa ttaagtccaa 3241 atacaaatat ttttgtaggt aataatgctc aagggaaaac taatatacta gaaagtatat 3301 attattcaag tatagggaag tctcatagaa caaataaaga taaagatctt ataaaatggg 3361 ataaaaataa tacatactta agaacatatg tatccaggga aagattagat aaaactatag 3421 atataaatat atttaaaaat ggcaaaaaag ctataactgt aaataaaata aaaataaaaa 3481 aaatatctga actaatgggg aacttaaatg ttgttatgtt ttctccagaa gacttaagaa 3541 taattaagga ttcccctgga aatagaagga aatttctaga tatagaatta tgtaaaataa 3601 acaatgttta ttatcatgat ttagtccaat ataataaaat tttatctgaa agaaatacag 3661 ctttaaaaaa ttggaataat aaaattaatg atataattga tatttatgat gagcaacttt 3721 ctaaatatgg agcttttata attaaagaga gaaataagta tttggataaa ttaaatatta 3781 ttggcaaaaa tatacataag aagataacca atgatttaga agacataaac tttaggtatt 3841 taactaatat aaaggatttt gataacgcag aaaaagaatt attaatgttt tttaagaaaa 3901 atcgaaaaaa agattttgag agaaattcaa cttctattgg tcctcaccga gatgattttg 3961 aagtcagtat aaacaatata gatactagaa tttttggatc acaaggacaa caaagaacag 4021 ctgtattaac tttaaagttt gcatcattgg aaataataaa aaatataata ggggaatatc 4081 ctgtactttt attagatgat gtgctatctg aattagattc aaatagacaa aagtttgtat 4141 tgaattctat tgataaaata caaactataa taacttgtac tggtatagaa gaaatagaca 4201 aatacttaga taagaaacaa tctcaattat atttagttaa taatggtaag ataaaaagag 4261 tttaaagctg aaaggagatt aatttatgtt tcttcactta ggagaaaatg tagtagtacc 4321 aataaaagat gttataggaa tattcgacat ggaaacttct atgtatagtt cagatactat 4381 acaattttta agattagctg aagaggatgg atttgttgaa agaataacta aagagaaacc 4441 aaaatctttt gttatagctg aagtagataa aaagagtaag atatatttgt ctcctatatc 4501 ttcagctacg ctaactaaaa gaacaaaagt tttgtataat gagctgtaaa agttaggagg 4561 ataaacatgc cacaagaaaa taaacaagtt tatgatgaaa gtcaaattca agtgttggaa 4621 ggtttagagg ctgttagaaa aagaccaggg atgtatattg gaagcactag tttaagggga 4681 cttcatcatt tggtttatga aatagttgat aatagtatag atgaagcatt agctggtttt 4741 tgtacacata tagaagtttt tatacacaaa gataattcta taactgtggt agatgatggc 4801 cgtggaatgc cagttggtat gcattcaaag gtaaaaaaac ctgctgttga agtaataatg 4861 actatattgc acgcaggtgg aaaattcggt ggtggaggat acaaagtttc tggtggtctt 4921 catggtgttg gagcttctgt tgttaatgct ctatcagaac attgtaatgt agaagtaaga 4981 agagatggac atatatggct tcaaaaatat gaaagaggca taccaaaaac aggattagat 5041 atagtaggag atacagagaa acatggtacc aaaatatact ttaagccaga tgttgaaata 5101 tttgatgaac tagaatttga atatgacacc ttagctcaaa gacttagaga gttagctttc 5161 ttaaataagg gtataaaaat ttcattaaca gatgaaagat atgataaaca agaaatgttc 5221 cactatgagg gtggattgag atcttttgta ctttatttaa acagaaataa ggaaaaatta 5281 catcaacaac ctatatatgt tgataaaaat aaagatggat gtatagttga gattgctatg 5341 caatataacg atggttatgc agaaaacatt ttttcatttg ctaataatat agacacaata 5401 gaaggtggaa ctcatttagc tggatttaaa tcagctttaa caagagctat aaatgactat 5461 gctagaaaat ttaattactt aaaggataca gataaaaatt tatcaggaga cgatgttaga 5521 gaaggtctaa cagcagttat ttcagtaaaa ttaacagatc ctcaatttga aggacagaca 5581 aagacaaagt taggaaatag tgaagtaaga ggaattgtag atacaatagt aggtgaaagc 5641 ataggttcat ttttagagga aaatcctaat gtaggtaaaa taataattga aaaaggctta 5701 tcagcctcaa gagctagaga agctgcaaaa agagctagag aacttactag aagaaaatct 5761 gttttagaaa gtacttctct tcctggaaaa ttagcagatt gttcttcaaa ggatccatca 5821 ttatgtgaaa tttatttagt cgaaggagac tccgcaggag gatctgctaa acaaggaaga 5881 aatagagaat ttcaagctat attaccttta aagggtaaaa taatgaatgt agaaaagcaa 5941 agattggata agatattagc ttcagatgaa atacgtgcta tgataactgc atttggagcg 6001 ggtataggaa aagaatttaa ccttgagaaa ataagatata atagaataat tataatgaca 6061 gatgctgacg tagatggagc ccatataaga actctacttt taacattctt ttatagatat 6121 atgaaagaat tagtagagga aggtcatgtt tatatagctc aaccaccact ttatagaata 6181 tataaggcta aaaaggaact ttatgtttat tcagataaag aattggatga ggcattgtta 6241 gaattaggtg gaaaagatac taatactaat attcaaagat ataaaggtct tggagaaatg 6301 gatccagaac aactttggga aactactatg aacccagaac atagaacttt attacaggta 6361 acaatagagg acgctatggc agcagatgaa atatttacca tacttatggg aacaaaagta 6421 gaaccaagaa gggactttat agaaaataat gctgataaag tagttaactt ggatatataa 6481 gataagattg taaagaggtg taatcatgct aaacgaagga aagattttgc ctgtagatgt 6541 aagtaaagaa atgaaaaaat gttatataga ctatgccatg agtgtaatag ctggccgtgc 6601 attaccagac gtaagagatg ggttaaagcc agtacataga agaataatat attcaatgca 6661 gggattagga ttagctccgg aaaaaggtta tagaaaatgt gcgagaattg taggggatgt 6721 actaggtaag tatcatcctc atggtgatac agcagtttat gaagctttgg taagaatggc 6781 tcaggatttc tcaataaggt atacattagt agatgggcat ggaaactttg gttctgtaga 6841 tggcgatgga gcggcggcaa tgagatatac agaagctaag atgagcaaaa tatccatgga 6901 acttataaaa gatataaata aaaatacagt tgattttatt cctaactttg atggtgaaga 6961 agaagaacca tctgtattac catcaaggtt tcctaatctt ttagttaatg gttctgcagg 7021 tatagcagta ggtatggcta ctaatattcc acctcataat ttaacagagg ttatagatgg 7081 aataataatg ctaatagaaa atgaagatgt aagtatactt gatttaatga ctaaaataaa 7141 aggaccagat tttcctactt ctggattaat cgtaggtaca agaggaataa gggaagctta 7201 tgaaacgggt aggggaaaag ttataattag agctaaagct gagattgaag aagaaaaagg 7261 taaaaataga ataatagtta cagaaatacc ataccaggtt aataagtcta agcttataga 7321 aaatatggct aaccttgtaa aggataaaaa aataaacggg atctcagata taagagatga 7381 atcagacaga caaggtatga gaattgttat agaactaaaa agagatgcaa atcctaatat 7441 agttttaaac caattatata agcatacaaa acttcaagat acctttggaa taattatgtt 7501 agcgttagtt aataaccaac ctcaagtttt aaatttaaaa gaaatattag ttaattatgt 7561 ggaattccaa aaggaagtaa taagaagaag aactagattt gacttagata aagcattagc 7621 aagggctcat atattagaag gtttaagaat agctttagat catattgatg aagttataaa 7681 gcttataaga gcatctaaaa atacagctga agctaaagag ggattaatga ataactttaa 7741 tctttcagaa aaacaagctc aagctatatt ggatatgaag ttacaaaggc ttacgggttt 7801 agaaagagaa aaaatagaag aagaatataa agaacttatg gaaaagataa gttattttag 7861 agaaatatta gataaagaag aattagtact aagtataata aaagaagaat taatagagat 7921 aaaaaataaa tatggtgatg aaagaaaaac agaaatagta aaaggtgagc atgatataga 7981 tatagaggac ttaattgaag ataaaaaggt aataataact ttaactcatg gtggatacat 8041 aaaaagatta gatatggata catactcttc acaaaaaaga ggaggaaagg gtattcaagc 8101 tacatctaca aaacaggatg attttataga aaatatgttt gtaacatcta ctcatagtat 8161 tatattattc tttacaaata gggggaaggt atataaactt aaagcttatg aaataccaga 8221 agcaggaaga acagctaaag gtacaaatat agtaaatctt atacctatag aaaataatga 8281 aaaaatacaa acagtaatag gattaaaaga catagatgat atgaaacatt ttgtaatgtg 8341 tactagaaat ggaataatta aaaagacaga aataaagaaa tattcttcta taagaaaagg 8401 tggattaaat gccataaatt taagagaaga tgatgaacta atagatgtaa aaatgactaa 8461 aggaaataat gaaataataa tagtcacaca aaatgggtac tgcataagat ttaatgaaga 8521 agatgtaagg cctatgggaa gagttgcaac aggagttaag ggtataacat taagagaaga 8581 tgataaagct gtatctatgg aggtagtgtt agaagatgaa gcactactat caataagtga 8641 aaatggattt ggaaaaagaa cagatataga agaatatcct atccatagaa gaggtggaaa 8701 aggtgttata acttataaaa taacagataa aacaggacct atagttggag caaggtttgt 8761 aaaagaagat gatgaactta tgcttgtaaa tagtggtgat gttgcaataa gaataaatgt 8821 ttcagaaata tctaaaacta gtagaaacgc tatgggtgta aaattaatga gaactagtga 8881 agaagaaaaa atagtagcta tagctaaaat aaagagtgaa gatataatag aagaagaaat 8941 tttaaatgaa gagaatttaa atgaagagaa tttaaatgaa gaataaataa taagaaagat 9001 cagcattaat gctgatcttt cttattataa attttaatta taaaaaacaa cttttccaga 9061 cgtatcaata taagaaatat aaataaaaac gataaaaata gaagaaatat tatcatattt 9121 gaatcaaaca gagttttatg ttataaatat aatattaaat tttgatacaa tgaatctcgt 9181 ccttaagaca aggacttgaa agtaacaaaa acttttaaaa acaaatttga aaaaagttct 9241 tgacaaagaa caacaaattt gataagatat aaaagtcgct gaggcgatgt ggtctttgaa 9301 aattaaacag agaattaaca agaaacattc ttgtaacagc cagtaagata aggtaatata 9361 ccttgtcaat gaatttgaga agagattaaa cttttaaatt tagagtttga tcctggctca 9421 ggacgaacgc tggcggcgtg cttaacacat gcaagtcgag cgatgaagct tccttcggga 9481 agtggattag cggcggacgg gtgagtaaca cgtgggtaac ctgcctcaaa gtgggggata 9541 gccttccgaa aggaagatta ataccgcata atataagaga atcgcatgat ttttttatca 9601 aagatttatt gctttgagat ggacccgcgg cgcattagct agttggtaag gtaacggctt 9661 accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacattgg aactgagaca 9721 cggtccagac tcctacggga ggcagcagtg gggaatattg cgcaatgggg gaaaccctga 9781 cgcagcaacg ccgcgtgggt gatgaaggtc ttcggattgt aaagccctgt tttctaggac 9841 gataatgacg gtactagagg aggaagccac ggctaactac gtgccagcag ccgcggtaat 9901 acgtaggtgg cgagcgttgt ccggatttac tgggcgtaaa gggtgcgtag gcggatgttt 9961 aagtgggatg tgaaatcccc gggcttaacc tgggggctgc attccaaact ggatatctag 10021 agtgcaggag aggaaagcgg aattcctagt gtagcggtga aatgcgtaga gattaggaag 10081 aacaccagtg gcgaaggcgg ctttctggac tgtaactgac gctgaggcac gaaagcgtgg 10141 gtagcaaaca ggattagata ccctggtagt ccacgccgta aacgatggat actaggtgta 10201 gggggtatca actccccctg tgccgcagtt aacacaataa gtatcccgcc tggggagtac 10261 ggtcgcaaga ttaaaactca aaggaattga cgggggcccg cacaagcagc ggagcatgtg 10321 gtttaattcg aagcaacgcg aagaacctta cctggacttg acatcccttg catagcctag 10381 agataggtga agcccttcgg ggcaaggaga caggtggtgc atggttgtcg tcagctcgtg 10441 tcgtgagatg ttaggttaag tcctgcaacg agcgcaaccc ttgttattag ttgctaccat 10501 taagttgagc actctaatga gactgcctgg gtaaccagga ggaaggtggg gatgacgtca 10561 aatcatcatg ccccttatgt ccagggctac acacgtgcta caatggtagg tacaataaga 10621 cgcaagaccg tgaggtggag caaaacttat aaaacctatc tcagttcgga ttgtaggctg 10681 caactcgcct acatgaagct ggagttgcta gtaatcgcga atcagaatgt cgcggtgaat 10741 acgttcccgg gccttgtaca caccgcccgt cacaccatga gagctggtaa cacccgaagt 10801 ccgtgaggta accgtaagga accagcggcc gaaggtggga ttagtgattg gggtgaagtc 10861 gtaacaaggt agccgtagga gaacctgcgg ctggatcacc tcctttctaa ggagaataga 10921 aagaagaaaa ttctttctaa aggctgaatt ctctgtttaa ttttgagaga ccattctctc 10981 aaaatgaagt taaacattag tatgtttaac taagtgactg taccaaatca tagatttgga 11041 acatcaactt atgttctttg aaaattgcac agtgaataag taaagctaaa ggtataaaaa 11101 tcctttgtaa gaatacaatt ttaaggtcaa gctacaaagg gcgcatggtg aatgccttgg 11161 cactaggagc cgaagaagga cgcgataagc tgcgataagc cttgggtagc cgcaaatagg 11221 ctgagatcca gggatttccg aatgaggaaa ctcacatggg taaccccatg tattatgcac 11281 tgaatacata ggtgtatgag ggtaaacccg gggaactgaa acatctaagt acccggagga 11341 agagaaagaa aaatcgattt cctaagtagc ggcgagcgaa cgggaaagag cccaaaccag 11401 aaacttgttt ctggggttgt ggatagatca tgaaagaaga ggtatcttaa tcgaagaggg 11461 ctggaacgcc ctaccataga aggtaatagt cctttaggta aaaagagaaa acttcgagat 11521 ctaatccaga gtaccacgag acacgtgaaa ccttgtggga agcagggagg accacctccc 11581 aaggctaaat actacctagt gaccgatagt gaagcagtac cgtgagggaa aggtgaaaag 11641 aaccccggaa ggggagtgaa atagaacctg aaaccgtgtg cctacaaccg atcggagcac 11701 gttaaagtgt gacgatgtgc tttttgtaga acgagccagc gagttacgct atgtagcaag 11761 gttaagtact taaggtatgg agccgaaggg aaaccgagtc tgaaaagggc gaaaagttgc 11821 atggtgtaga cccgaaaccg ggtgacctat ccatggccag gttgaagcga gagtaaaatc 11881 tcgtggagga ccgaaccacg ttggtgttga aaaaccatgg gatgagctgt ggatagcgga 11941 gaaattccaa tcgaactcgg agatagctgg ttctcctcga aatagcttta gggctagcgt 12001 cgtgtaattg agtaatggag gtagagcact gaatgggcta ggggctatag tagttaccga 12061 accctatcaa actccgaatg ccatatactt gtatcacggc agtcagactg cgaatgataa 12121 gatccgtagt caaaagggaa acagcccaga ccatcagcta aggtcccaaa gtgtaagtta 12181 agtggaaaag gatgtgggat ttctaagaca actaggatgt tggcttagaa gcagccactc 12241 atttaaagag tgcgtaatag ctcactagtc aagagatcct gcgccgaaga tgtccggggc 12301 tcaaacttac caccgaagct atgggtgtac actatgtgta cgcggtagag gagctttctg 12361 tatgggttga agtcgtaccg taaggagcgg tggactgtac agaagtgaga atgctggcat 12421 aagtagcgag aaataagtga gaatcttatt ggccgaaaac ctaaggtttc ctggggaagg 12481 ttcgtccgcc cagggttagt cgggacctaa gccgaggccg aaaggcgtag gtgatggaca 12541 atcggttgat attccgatac cgcctattta cgtttgagaa atggggtgac gcagtaggat 12601 aagatgtgcg cactattgga tgtgcgtcta agcatttagg catgcttgat aggtaaatcc 12661 gtcaagctaa gctgaggtgt gatggggagc catttatggc gaagtatctg attccacact 12721 gccaagaaaa gcctctatcg agtgaatagg tgcccgtacc gcaaaccgac acaggtaggt 12781 gaggagagaa tcctaaggcc atcggaagaa ttgctgttaa ggaactcggc aaattgaccc 12841 cgtaacttcg ggagaagggg tgcctacgaa agtaggccgc agagaatagg cccaagcaac 12901 tgtttagcaa aaacacaggt ctctgctaaa gcgaaagctg atgtataggg gctgacgcct 12961 gcccggtgct ggaaggttaa ggggaacact tagcgtaagc gaaggtgtga acttaagccc 13021 cagtaaacgg cggccgtaac tataacggtc ctaaggtagc gaaattcctt gtcgggtaag 13081 ttccgacccg cacgaatggc gtaatgattt gggcactgtc tcaacagcaa atccggcgaa 13141 attgtagtgc aagtgaagat gcttgctacc cgcgattgga cggaaagacc ccgtagagct 13201 ttactgtagc ttagcattga atctcggtat tgtctgtaca ggataggtgg gagacttgga 13261 aacttgggcg tcagcctgag tggagtcatc cttgggatac caccctgaca gtactggggt 13321 tctaaccggc ggccatgaat ctggtcacgg gacattgtta ggtgggcagt ttgactgggg 13381 cggtcgcctc ctaaaaagta acggaggcgc ccaaaagttc cctcagcgcg gtcggaaatc 13441 gcgcgaagag tgcaaaggca gaagggagct tgactgcgac acatacaggt ggagcaggga 13501 cgaaagtcgg gcttagtgat ccggtggtac ctcgtgggag ggccatcgct caacggataa 13561 aagctacctc ggggataaca ggctgatctc ccccaagagt ccacatcgac ggggaggttt 13621 ggcacctcga tgtcggctcg tcgcatcctg gggctgaagt aggtcccaag ggttgggctg 13681 ttcgcccatt aaagcggcac gcgagctggg ttcagaacgt cgtgagacag ttcggtccct 13741 atccgtcgcg ggcgtaggaa atttgagagg agctgtcctt agtacgagag gaccgggatg 13801 gaccaacctc tggtgcacca gttgtcacgc cagtggcaca gctgggtagc tatgttggga 13861 ctggataaac gctgaaagca tctaagcgtg aagccaacct caagatgaga tttcccatag 13921 cgtaagctag taagactcct ggaagaacac caggttgata ggtcagagat ataagcatgg 13981 caacatgtta agttgactga tactaataag tcgagggctt gaccaaaata aattcactgt 14041 gtaattttga gagaaacaat aaaaaaattg ttaaatctct attgacaaat tgaaaaaaag 14101 caattataat gttaaatatc tggtgattat ggcttgaagg taacacccgt tcccatgccg 14161 aacacgaagg ttaagcttca aagcgctgat ggtactgcag gggaagccct gtggaagagt 14221 aagtcgttgc caggtgaaaa catggatctt tagctcagtt ggttagagca accggctcat 14281 aaccggtagg tccggggttc gagtccctga aggtccacca tttgggggta tagctcagtt 14341 gggagagcac ctgccttgca agcagggggt caggagttcg aatctcctta tctccaccat 14401 gatataagat acttatgaat tttcataagt atcttatttt tttatatcca tttaaaaaat 14461 aagaaattta ttgtaaactg ataatataag attattttaa taaggaggtt aataaaatag 14521 tatatagaat taaacaattt cactggaacg ctactgctaa aatggagtat aaagacatag 14581 tatatataaa tatgcattta gataatgaag aattaaagat ttttaataaa ttatctataa 14641 gcgaacaaaa gcattctata aaggtagctt atgatataga aaaattatat gaagaaggta 14701 aatataatct aacaaaagat gagtttataa aggtagcttt gttacatgat ataggaaaat 14761 taaattataa agttgatatt ataaaaaaaa gcataatagt aattgtagat aaaattacaa 14821 attctagaat aaaaaaattt caaaatatta agtcagttta tgttcattat aatcatcctt 14881 atttaggtta ttgtatttta aaacaatata ataaatatag tgaaaaaatg ttatatttaa 14941 ttaaaaatca tcataatgaa aatattataa ataaagagtt aagcttatta atatatagtg 15001 ataatttaaa ttagtaaggt ggtgatatta tgaattcaat ggaaagaaga aaaaatattg 15061 aagacatgtt aatgaaaaac aataaaccta ttaaaggtag tgaaatagga gaaaaattag 15121 gtgtgacaag gcaggttata gtaaaagata tagctatttt aagagcttct ggtaaaaata 15181 taattgctac acctgaaggc tatttaatac ctaatgaaaa taaacaatta ataaggaaaa 15241 ttatagctgt atgccatgat agtaaagata taaaagacga attagagatt ataattaaat 15301 ttggaggaat agtagaagat gttgtagtag agcatcctat atatggagaa ataaaagcca 15361 tgttgatgat aaaatctatg tatgatatag gtaattttat aaaaaatata caaaacaata 15421 aagcggaacc gttattaata cttactggtg gaattcattt gcatacaata tcttcagata 15481 atgaagatat aatgaataaa ataatagagg aattaaacca aaaaaattat ttagtagatg 15541 aggaaatata aaatggataa agtagccctt ttaaaatgtg atgaatatga tttagaaaaa 15601 gtagagaaaa ctataagaaa tggatttgaa cttttaggag gaaactcttt tttaaacaaa 15661 cttatacctt ataatagcaa agttcttttg aaacctaata tgcttagtat tgaaaatgaa 15721 ggttctcctg tagtaactaa tagtgtagtt tttgaagcag taataagaat attaagagat 15781 tattctagta acatatcctt tggagattct cccggatttg gagattctaa aagagcagct 15841 gaaaaatctg gattacttaa tatagcaaat aaatataata taacatttaa agattttaaa 15901 gaatctatta atgtaagttg tgataattct attttatgta gatcctggac tgtagcgaaa 15961 gcagcttatg aaacagatgt actaataaca ttacctaaat taaagacaca tgctatggct 16021 tactttacag gtgcagttaa gaatcagttt ggatgtatac caggaacttt aaaagctact 16081 tggcatacaa gaatgcctaa tgcaaataat ttctgtaaaa tgttattaga tttaaataca 16141 ttgttagaaa ctgattttgc tatactagat ggcattatag ctatggaagg gaatggtcct 16201 aaaaatggaa ccccttataa tcttaataca attataatgg gggatagcct tacagcggta 16261 gattccgttg ctgttaaaat aataggatat gacaatccat tagagatacc tgtattaaaa 16321 gaagcttatg atagcaattg gggaagtgtt tttttaaagg acatagatgt attaggtgaa 16381 aaaatagata gcatggttgt agataatttt aaactttgta gagagggtgg ggatttttat 16441 tttataaatc ctaaagttac aaatttttta aaggatatta ttgcaccaga tcctacttta 16501 atagaagaaa agtgtatagg atgtaataga tgtgctgaag tatgccctga aaaaccatat 16561 gttatagata tgataaaaaa agagggtaaa aaaataccag tttggaatat gaaaaaatgc 16621 ataagatgtt tttgttgtca ggaactttgt cctaaaggag ctatagaaac taaatattct 16681 tttattggaa gatttttaaa tagagatggc aggtgataaa atgaaaaata aaaaagcatt 16741 gtttatacca ttattcataa taattttatt tatagcattt tttaataaaa taataaattt 16801 tattattaat ataaaatggt ttaaagaagt aaactattta acaatatatt ttactaaaat 16861 gagagctata attattttaa tgattcctat atttataata ttttttatat ctatatggat 16921 gtattataaa agtcttatga taaataagaa taaaagtata gtagatatag gattaaataa 16981 aaacgattat gggaaaaaat tattctttat ttttaacttt atagcatcta tatttttagc 17041 ttatatattt tcaagcagct attggtatag aatattacaa tttaataatt ctgtagattt 17101 taatgtgaaa gatcctatct tttttaaaga tgtttctttt tatgtattta agttgccact 17161 ttttgaatct ttatataaag ttataatttc tttattatta tttttagtta taacaacatt 17221 tatagcttat tttattttag aagctaaata taaaattcaa agcaaaaagg atataaattt 17281 aaaaaatata aatcatggca taaaatcctt tgcaggaaaa caattagcta ttgtatctgg 17341 tcttataatt ttatttatat cctttggaca tttaataaaa atatggaatt tagtttatag 17401 ctctaatgga gtatcttttg gtgctagcta tactgatgtt catgctactt tattattcta 17461 taaaataata gtagtaatta cactaatttc atctatagta acattattaa gtatagtaaa 17521 aggtaaattt aagccagtaa gtatatgtat aggtataact atatttttga tagtatcaca 17581 aaatatagca tcttttttag tacaaaactt tatagtcaaa tctaatgaaa aaactttaga 17641 gcagccatat ataaaaaata atatagattt aacaagaaaa gcttttgcat tagatgatat 17701 tgaaataaga gattttgata ttaaaaatga tttacaaaag caagatatta cagataacaa 17761 agcaagtata gataatataa gaataaattc ttttaagcct acattagaat tttataatca 17821 agttcaaata ataagatatt actatacttt taatgacata gatatagata ggtataatat 17881 aaatggaaaa tataatcaag tattcctagc tgcaagagaa atagatacag atgccttgaa 17941 cccaaataca tggcaaaata gacacttaat atatacacat ggttttggag cagttatgaa 18001 taaagtaaat tctgtaacaa gtgaaggaca acctgacttt gttataaaag atataccacc 18061 ttataataaa acaaatataa aattgactaa tcctaggata tattttggag aaaagaccaa 18121 tgactatgtt atagtaaaca ctaagataaa tgaatttgat tatcctaaag aagattctaa 18181 taaaactaat aaatataatg gacatgcagg gataaaaatg agctttatta atagattatt 18241 attttctata aataaaaaag atattaattt tcttttatca aaggatataa aaaaagatag 18301 taaaataata ataaatagaa atattgtaga gagggcaaaa aaaatagcac cctttttaac 18361 ttatgatagt gatccttata tggttatata taatggcaaa atatattgga taatagatgc 18421 ttatactact acaaatagat atccttattc agagccttac gatagtataa attatataag 18481 gaattcagct aaagtagtaa tagattctgt agatggagac atcaattttt atattacaga 18541 taaaaaggat cctatagtta ataattatga taaaatattt aagggattat ttaaagaaga 18601 aaaagatgcg cctaaagaaa taagagaaca ttttagatat ccaaaagatc tatttagtat 18661 tcaaagcaaa gtattaggaa aatatcatgt aaaagatcct ggtgtgtttt ataatggtga 18721 agatctatgg gaagtatcta aggatcaaaa acatgttgaa ggagaaacaa atacaaatga 18781 tgctccttat ataattatga aattaccaga ccaaaataag gaagaaatgg tacttttgaa 18841 ttattttaat gtaatgaaaa aggataatat gatagcttta tttggagcaa gaatggatgg 18901 agagcaatat ggtaaaaaaa tattatacaa acttccatca gacaaaacag tatatagtcc 18961 atatttattt aagcaaaaaa taaatcaaga tactaatata tctaaggaat tatcattatg 19021 gaatagggaa ggttcacagg tgcaatatgg agacactata atattaccta taaaaaattc 19081 tcttctttat atagaaccac tatatttgcg agctagtggg aaaaatagta taccagaaat 19141 gaaaagagta atattatcct ataatgataa attagtttta tcacctagta ttcaggaagg 19201 tataaaagaa atatttaatt ctaaagataa taaaatcaat gataaaaatg aaaaagatag 19261 tacaaagact atagatgatt caaaattgaa aaaagctcaa gaatattata ataaagccat 19321 agaagctcaa aaaaatggag actggactaa atatggagaa aatataaatg aattaggtaa 19381 tatattaaat agtataaaat aa //