LOCUS NC_012658:22 18191 bp DNA linear BCT 04-SEP-2013 DEFINITION Clostridium botulinum Ba4 str. 657 chromosome, complete genome. ACCESSION NC_012658 SOURCE Clostridium botulinum Ba4 str. 657 chromosome, complete genome. COMMENT locus start: 3213498; locus end: 3231688 COMMENT n1_4mer:GRV/n1_4mer:RV = 3.529264; n0_4mer:D = 18.200794; n0_4mer:PS = 35.357534 FEATURES Location/Qualifiers source 1..18191 /organism="Clostridium botulinum Ba4 str. 657 chromosome, complete genome." gene complement(1..699) /gene="" /locus_tag="" /db_xref="3213498..3214196" CDS complement(1..699) /gene="" /product="diacylglycerol kinase/PAP2 family protein" /translation="MKVNKLLDSFNYAIDGIIHAVRTQRNMRIHMLSALLVLTACFFY DLSKIELVVVCITITLVIFAELMNTAIEFAIDATTNYYHPLAKVSKNVAAGAVLLTAI NAVVVGYIIFWDKLKYINFVLITKIKNSNPYAIFIILAIVCIVTVVVKAIYGEGTPLK GGMPSGHSTMAFSIATIIALITKEFPVVTLSYFLAFIVAQSRVDSEVHSILEVIVGAL FGTLFTTFLYKIFG" gene complement(740..1240) /gene="" /locus_tag="" /db_xref="3214237..3214737" CDS complement(740..1240) /gene="" /product="putative metalloprotease" /translation="MIYIDNRQNKIKVNEEFENKIKEIIDYALKEEKVNIDYEISVVF IDNNSIKEINKDYRNIDKATDVLSFPMLDYEEGKVFKDVYLNYEFDESDLDEGNLILG DIALSLEKAEEQSKEFGHSFLRETCYLTIHSVLHLLGYDHMEEEEKAIMRQREEEILK SFNLRR" gene complement(1237..3324) /gene="" /locus_tag="" /db_xref="3214734..3216821" CDS complement(1237..3324) /gene="" /product="putative hydrolase" /translation="MKKITMEEIKKDNKLKRVLVFFITFLFMYVVLITSFVTKKYDLQ EGDIAKVDIKAPREIKDEVSTKARLQQALESVPIQYTKRTEVKTEILNEINSFFSQAN SLKDKRIDERQKVQQLDQNGKINISERELSQILNLDKSELKSMQDVLIKVISDVYENV NISDDSQKDNAQDIKKAQEYVYSKIKMSKITNPLRQLAINIAYSEIKPNFYYDKEKTE ELKKETLKNTPPVMIKKDQTIVKEGEPVSKYQLDLLKDIGLLNNNNNFEWYIFIGLGV LIILVLFIQYVYIYKFYNEVFNDLNSLVLISLNNCIAILLARSIYTISPFLIPLASIP MILTLLLNYKISLVTSLVNCILIAVAVNFEVEIILIAIMSAVLGSTILRKMQERNDIL YASSYIAIINVILTFSAGFLLSNSVIDVSKKALFTLIGGVLSAILTIGLLPLFENLFD IVTTIKLLELSNPNNPLLKKLLLEAPGTYHHSILVGNLAEVAAEVVNGNPVLARVSAY YHDIGKTKRPYFFKENQIGRENPHDKISPNLSTLIITSHVKDGLELAKEYKIPKVIQD IIQQHHGTSLVKYFYITMKNNSERPEDVNEEDFRYQGPIPKSKEAAIIMLADGVEAAV RSINEPTKGKIEEMVNKIIKARLDEGQLDDCDLTLKEIGLIRDAFLKVLISIYHQRIE YPEDKWIRDRRIK" gene complement(3347..4507) /gene="" /locus_tag="" /db_xref="3216844..3218004" CDS complement(3347..4507) /gene="" /product="sporulation protein YqfD" /translation="MKFDKYKNANITIEIQSMIPERFINLLWKNGVKVKNVVKTNVTT FVLDIDLKDYAVMENIARRTGTKVTIVKRKGISFLILFLKRRFSLVIGIFIFSFIIYF MSTFIWDIDITSTNGVTPYEIRQQLKKYGIKPGINKNTIDVYKLEEKLIKDIDNIMWV KARIEGGKLVVKAEERQSPPTIVKEDEPCDLVAKKDGEVQRVYTTSGSAIVQNGDIVK KGDILIKGEQGKEGETYEVHSEGKVFARTFYEEIKTINTYRIKRKRTGKKIERTYINF KGKKLYLKKTINKFEKYDRIENNKLFITKETLYEVKETKENINLKKAIDEENEKIYKN ITKNLDKSVKVVDKITNYSPEGESCKIRMLIIAEEDIAVPQKIEVTDKEEDS" gene complement(4497..4793) /gene="yqfC" /locus_tag="yqfC" /db_xref="3217994..3218290" CDS complement(4497..4793) /gene="yqfC" /product="sporulation protein YqfC" /translation="MGKRFYNAKETVANKLDLPRDIILNQPKIIVTGNEEISIENHRG VVVFEEKVVKINSGSGLISIYGKDFEILFMGGSTITLGGKFKSIEYEGSEVNEI" gene complement(4907..5353) /gene="" /locus_tag="" /db_xref="3218404..3218850" CDS complement(4907..5353) /gene="" /product="GatB/Yqey domain-containing protein" /translation="MSLKETLQDHWKQALKAKEKEKASTISMVRAAILLAEKNSGKTL EDSEIIDILSKEIKQRKEALEDFKKGNRQDLVDATNFEIEVLLKYLPQQLTEEEITEI IEKAVNETGANSMKHMKNVMSIVIPKTKGRADGKLVSEKVKNILSK" gene complement(5396..5572) /gene="rpsU" /locus_tag="rpsU" /db_xref="3218893..3219069" CDS complement(5396..5572) /gene="rpsU" /product="30S ribosomal protein S21" /translation="MSEIKVGENESLENALRRFKKKCARAGVLSEVRKREHYEKPSVK KKKKSEAARKRKFK" gene complement(5709..6053) /gene="" /locus_tag="" /db_xref="3219206..3219550" CDS complement(5709..6053) /gene="" /product="HIT family protein" /translation="MENCIFCKILKGEIPSSKVYEDELVYAFNDIDPVAPHHVLIIPK EHISSLNELTEENSKVISHIFMVAKKIAKDLNISEEGYRVVSNCGESAGQTVFHIHFH LIAGRNLQWPPG" gene complement(6110..7408) /gene="" /locus_tag="" /db_xref="3219607..3220905" CDS complement(6110..7408) /gene="" /product="MiaB family RNA modification protein" /translation="MKVAFSTLGCRVNVYETEAMTEKFIKQGYEIVDFNEVADVYVIN TCTVTNMGDKKSRQMISRGRRQNSKAIIAVVGCYSQIAPEEVSKIDGVDVVLGTRNKG DIVYWVNRAMEEKNQVIEIKDVLRNKEFEELNIEEYRDKTRAFLKIQDGCNRFCSYCL IPFARGAVCSKKPEKIMEEVEKLSKHGFKEIILSGIDIASYGFDLEGKYNLTSILEEI DKVEGIERIRIGSIDPTFFTEEEIIGISKLKRFCPHFHLSLQSGCNETLKRMNRKYTV EQYKEIVHNLRTNIESVSITTDIIVGFPGETEEEFNKTYEFLKGIKLSKMHVFKFSPR KGTRAEEMKNQVDGKIKEERSNKIINLDKDLEKEFMNKFIEKEMPVLYEQETKEKGIF EGYTPNYIKIYSKSSKDITGEIINTTLKEVSKDFIKGEIY" gene complement(7408..8166) /gene="" /locus_tag="" /db_xref="3220905..3221663" CDS complement(7408..8166) /gene="" /product="16S ribosomal RNA methyltransferase RsmE" /translation="VHKFFVPAENIIDEKAIIDGDDVKHIYKVLRLECGDAININNCQ GKEYKGEIESIDKKSVVVKILEQVEVNNENPLNIYLYQGLPKSTKMDLIVQKSTELGI KEIIPVITERVEVKASLKEFKKLDRWNRIALEACKQCKRSLIPSVREPLKFNDLLEET KGMDLIVVPYESKENYGIKSLIKNIEYEKENIKNIGIIIGPEGGFEESEIRALEEIKA QIVTLGPRIFRTETAGIVCASIISYELGDLGGNI" gene complement(8264..9202) /gene="prmA" /locus_tag="prmA" /db_xref="3221761..3222699" CDS complement(8264..9202) /gene="prmA" /product="ribosomal protein L11 methyltransferase" /translation="MDKEWLEVCIYTSSEALEAISGILYNTGVKGVSIEDPKDIEFKK KHPGDWDYFDETLLKVKDTAIVKGYYKEDDKFNEYLDYIKKSVSNLDQFGIDKGKGLV EVHKVNEEDWENNWKKYYKPTKVSNKIVIKPIWENYDKKQEEIIVELDPGMAFGTGTH ETTRMCINALEKHIKEDRTVFDIGCGSGILSIAAAKLGAKHVIGVDLDPVAVKSSKEN IKYNNLDNIEILEGNLMEVVEGRANIVVANIIADVIIFLTEGVKAFIEKDGYFIASGI INSRKEDVIKKLEETGFVIEEVREEGEWVCIVSKIN" gene complement(9561..10706) /gene="dnaJ" /locus_tag="dnaJ" /db_xref="3223058..3224203" CDS complement(9561..10706) /gene="dnaJ" /product="chaperone protein DnaJ" /translation="MPSKDYYALLGLEKGASEQDIKKAFRKLAIKYHPDKNKGNKEAE EKFKEINEAYQVLSDPQKKAQYDQFGTTDFNGAGGFDSSGFGGFDFSDMGGFGDIFDS FFGGGFSSGGRRKNGPQRGADIETAIDLTFEEAVFGAEKEISVNKHENCDNCNGTGAK PGTSPKDCDKCGGTGRIRIQKNTILGSMVTETSCDKCGGSGKVIENPCNKCHGKGKIR KNKKIKVNVPAGVDTGNVIPLRGQGEPGNNGGPTGDLYINIRVASHPTFKRKGFDIYI EKHISFAQAALGVEIKVPTVDGEVKYEVPAGTQPGTVFRLKGKGVPRINSTARGNQYV TIIVDIPKKLNSKQKEALTMYMEASGETVEGKEKGTIFEKIKKGFKD" gene complement(10849..12720) /gene="dnaK" /locus_tag="dnaK" /db_xref="3224346..3226217" CDS complement(10849..12720) /gene="dnaK" /product="molecular chaperone DnaK" /translation="MAKIIGIDLGTTNSCVSVMEGGEPVVIPNAEGSRTTPSVVSFQA NGERLIGQVAKRQAITNPEKTIISIKRYMGTDHKVNIDNTEYTPQQISAMVLQKLKAD AEAYLGEKVTQAVITVPAYFNDSQRQATKDAGKIAGLEVLRIINEPTAASLAYGLDKM DTNEKILVYDLGGGTFDVSILELGDGVFEVKATNGDTKLGGDDFDQKLIDYIAETFKA ENGIDLRNDKMAIQRLKEAAEKAKIELSSATQTNINLPFITADATGPKHIDMNLTRAK FNELTHDLVQRTLEPIKKSLEGSGYAMSDIDKIIMVGGSTRIPAVQDAVKDFTGKELS KGVNPDEVVAMGAAIQAGVLTGEVKDVLLLDVTPLTLGIETFGGVSTTLIEKNTTIPT RKSQVFSTAADGQTSVEIHVVQGERSMAADNKTLGRFTLSGIAPAPRGIPQIEVTFDI DANGIVNVSAKDKGTGKEANITITASTNLTDDEIEKAVNEAKKFEAEDKKRKESIEVK NNADQIVYQTEKTLTDLGDKVSAEDKAQIEEKVKVVKDVKDGEDLEAIKKATEDLTQT FYGISSKIYQQANPEGAPGAGFDPNNMGGANAGNASAGNDKKDDNVVDADFKVEDDK" gene complement(12775..13419) /gene="grpE" /locus_tag="grpE" /db_xref="3226272..3226916" CDS complement(12775..13419) /gene="grpE" /product="heat shock protein GrpE" /translation="LEKECKDAKHINMEEDCCCSNKESENKEEDKGKEEDLEFEEIEK EEIIEDSEDSNEVKIKELEDMKNKLKEENKKLENQMEEIKERLVRTVAEYDNFRKRTA KEKEDLYVSACEDVLKELLPVLDNLERAANVEGSVEDIKKGIDMTVKQFGTSLEKLGV EEISTEVAFDPNIHNAVMHVEDSNCGEKEIVEVFQKGYKKGEKIIRYSMVKVAN" gene complement(13446..14477) /gene="hrcA" /locus_tag="hrcA" /db_xref="3226943..3227974" CDS complement(13446..14477) /gene="hrcA" /product="heat-inducible transcription repressor" /translation="MDERKIRILQAIIKDYINSGEPVGSRTIAKKYDLGVSSATIRNE MADLEDMGYLEQIHSSSGRKPSDKGYRLYVDKLMILTALTEQEKMLIKDQAIDSALYE IDKTIRHSISILSEITKLTCLVKTPSMIKSRLRSIQIIKVDKYNLLLIVITDNAMIKN TLLRVTKEIDEGSLIKINNLLNQKLKGLNLREVNLELLNELKKEMTGYGDILKNILSS IYEALTDIEDAEIYMEGTTNIFNYPEYNDVDRAKEFLSMLNDREKVEELLYADSDIAV KIGKENFVEDAKQCSVISAVYSIGKTPIGTIGVIGPTRIPYEKIISAVATIVKEINDT LTNDKNIHK" gene complement(14678..15820) /gene="" /locus_tag="" /db_xref="3228175..3229317" CDS complement(14678..15820) /gene="" /product="coproporphyrinogen III oxidase" /translation="LDREDKNKEVSLYIHIPFCMQKCSYCDFTSYSKKEDLMMEYVKA LSKEIVDNTKNKIIKTIFIGGGTPTYLSLEALNILKHTLKTIDKKENIEFTVEGNPGT FTEKKLKMLKSMGVNRLSIGLQSSKNSLLKTLGRIHSFEDFVHSFKMARKEGFNNINV DLMFALPNQSLDDWKDTLLTVVDLSPEHLSCYSLIIEEGTNFYNLYKNSLLKLPKEEE EREMYEYCIDFLRERGYLQYEISNFANPNKECRHNLVYWDLEDYIGCGVGAHSYVNNR RYENTSSIETYIKEINSNNLTQINFHINSQKENMEEFMFMGLRKTKGICIDDFQVRFG KNIIYIYGSVINKYKKLNLLIEKENRIYLSKEAVSISNTILSDFLL" gene complement(15847..17655) /gene="lepA" /locus_tag="lepA" /db_xref="3229344..3231152" CDS complement(15847..17655) /gene="lepA" /product="GTP-binding protein LepA" /translation="MQSERQKYIRNFSIVAHIDHGKSTLADRLIEATGTLTEREMDTQ VLDNMDLEKERGITIKSQAVRLIYKRDTGEEYTLNLIDTPGHVDFNYEVSRSLAACEG AILVVDATQGIQAQTLANCYLALDNDLEIVPVINKIDLPSARPEEVKQEIEDVIGIEA EGAPLVSAKTGLNIKDALEAIVNKVPAPDGDEKAPLKALIFDSYYDSYKGVVCHIRVK EGTIKEGTEIKLMNTGKVYEVVEVGVFVPNYMPVDELKAGDVGYVTASIKNVRDARVG DTITEAKRSANEALSGYRPAVPMVFSGIYPVDGAKYEELKEALEKLQVNDAALSFEPE TSIALGFGFRCGFLGLLHMDIIQERLEREFNLDIITTAPSVIYKITKTDGTLIELTNP TNMPSPSEIKLMEEPIVKSSIITPSDYVGAVMDLAQNRRGIFKDMQYLDTTRVSLNYE IPLNEIIYDFFDALKSRTRGYASFDYELIGYKDADLVKLDILLNADIVDALSMIVPRE RAYAKGRNMAQKLKEIIPRQMFEIPIQAAVGAKIIARETIKAMRKDVLAKCYGGDISR KRKLLEKQKEGKKRMRQVGSVEVPQEAFMAVLKTEE" gene complement(17796..18191) /gene="" /locus_tag="" /db_xref="3231293..3231688" CDS complement(17796..18191) /gene="" /product="hypothetical protein" /translation="MEIIKKKRKFKLNWNKYKTVILLSFLITISGFFIVSNTIPKFVK DRSKVAIYFTKKPLDIRFKTESYTFYINEKILNDIGDKTYKTFNNMKNSTSNFLNNIN RSHSLNKIGSVFYKIKEEVLGVFNGRGVK" ORIGIN 1 ctatccaaat attttatata aaaacgtagt aaataaagtt ccaaataaag cccccactat 61 tacctctaat atagaatgta cttctgaatc aactctactt tgagctacta taaaggctaa 121 aaaatagctt aacgtaacta cgggaaattc cttagttata agagctatta ttgtggctat 181 agaaaatgcc atggtactat gtccactggg cattcctccc tttaaaggag ttccttctcc 241 atatatagct tttaccacta cggtaactat acaaactata gctaatataa taaatatagc 301 ataaggattt gaatttttta ttttagttat taaaacgaaa tttatatatt ttagtttatc 361 ccaaaatata atataaccaa ccactactgc atttatagct gttaataaaa ctgctcctgc 421 tgctacattt ttcgaaacct tagctaaggg atggtaataa ttcgtagtag catctatagc 481 aaattctata gcagtattca taagttctgc aaaaataact aaagttattg ttatacatac 541 aactactaat tctatctttg ataaatcata gaaaaaacag gcagttaaaa ccaaaagagc 601 agagagcata tgtattctca tattcctttg ggtcctaact gcatgtatta ttccatctat 661 agcataatta aaactatcca aaagtttatt taccttcatg gctaatcacc atcctttaca 721 ggttaaaata aatgaatttt tacctgcgta aattaaagct ttttaatatt tcttcctctc 781 tctgtctcat tatagctttt tcttcttctt ccatatggtc atatcctaag agatgtagta 841 ctgaatgtat tgttaaataa caagtctctc ttaaaaaact gtgaccaaat tctttacttt 901 gttcttcggc tttctctaag gaaagtgcta tatctcctaa aattaaattt ccctcatcta 961 gatcactttc atcaaattca tagtttaaat atacatcttt aaaaactttt ccttcctcat 1021 aatctaacat tggaaaggat aatacatctg tagctttatc tatatttcta tagtctttat 1081 ttatttcttt tatactattg ttatctataa aaaccacact tatttcatag tctatattta 1141 ccttttcctc ttttaatgca tagtctatta tttcttttat tttattttca aactcttcat 1201 ttacttttat tttattctgt ctattatcta tatatatcat tttatcctcc tatctcttat 1261 ccatttatcc tctggatatt ctattctttg gtgatatata cttataagaa cctttaaaaa 1321 agcatctctt attagtccta tctcttttaa tgtaagatca caatcatcta actgtccttc 1381 gtccaatctt gcctttatta ttttatttac catttcctct attttaccct tagttggttc 1441 atttatagat cttacagcag cctcaacccc atctgctaac attattatag cagcttcttt 1501 acttttaggt ataggacctt gatatctaaa atcttcttca tttacatctt caggtctttc 1561 actattattt ttcatagtta tataaaaata ttttactaaa gatgtaccat ggtgttgctg 1621 tattatatct tgtataactt taggtatttt gtattccttc gctaattcta acccatcttt 1681 tacatgggaa gtaattatta aggtactcaa attgggggat attttatcat ggggattttc 1741 cctacctatt tgattttctt taaaaaaata cggtcttttg gttttcccta tatcatgata 1801 ataagcagat actctagcta gcactggatt cccatttaca acctctgccg caacctcagc 1861 taaattccct actaatatac tgtgatgata agttcctgga gcttctaata ataacttctt 1921 aagtaatgga ttattaggat tggaaagttc taaaagtttg atagtagtaa ctatatcaaa 1981 taaattttca aataaaggaa gaagccctat ggttagtatt gctgataaca ctcctcctat 2041 aagagtaaat aatgcttttt tacttacatc tataacacta ttgcttaaaa gaaaaccagc 2101 tgaaaaagta aggattacat ttataatagc tatataagat gatgcataca gtatatcatt 2161 tctttcttgc atttttctta atatagtaga acctaaaaca gcactcatta tagctattaa 2221 aataatttct acttcaaagt ttactgctac agctattaaa atacagttta caagactagt 2281 aactaaagat attttatagt ttaacagtaa agttaatatc ataggtatag atgctaaagg 2341 aattaaaaaa ggtgatattg tatatatgct cctagctaaa agtattgcta tacaattatt 2401 taagcttatt aaaaccaaac tatttaaatc attaaatact tcattataaa atttatatat 2461 atatacatac tgtataaaaa gcactaaaat tattagaact cctagtccaa taaaaatata 2521 ccactcaaaa ttattattat tatttaataa acctatatcc tttaacaaat ctaattgata 2581 tttagatact ggttctcctt ctttaactat tgtttgatct ttttttatca taactggtgg 2641 agtatttttt aaagtttcct tctttaattc ctctgttttt tctttatcat aataaaaatt 2701 aggttttatt tctgaataag ctatatttat tgccaattgc cttaaaggat tcgttatttt 2761 agacattttt atttttgagt atacatactc ctgtgctttt tttatatctt gtgcattatc 2821 cttttgagaa tcatcactta tatttacatt ttcataaaca tcagatataa ctttaataag 2881 aacatcctgc atggatttaa gttctgattt atctaaattt aatatttggc tcaattccct 2941 ttctgatata tttattttgc cattttgatc taattgttga accttttgcc tttcatctat 3001 tcttttatct tttagggaat ttgcctgtga aaaaaaacta tttatttcat ttaaaatttc 3061 tgttttaacc tctgtccttt tagtgtactg tataggtact gactctaaag cttgttgcaa 3121 tctagccttg gtggatactt catcttttat ttctcttgga gcttttatat caactttagc 3181 tatatcgcct tcctgtaggt catatttttt tgtaacaaaa gatgtaataa gcacaacata 3241 cataaataaa aatgtaataa aaaaaactaa tactctcttt agtttattgt ccttttttat 3301 ttcttccatg gtaatttttt tcatatatta taataccacc tttattttag ctgtcttctt 3361 ctttatccgt aacttctatc ttttgtggaa cagctatatc ttcttctgct ataattaaca 3421 ttctaatttt acagctctct ccttctggag aataattcgt aattttatct acaactttaa 3481 cagatttatc taagttttta gttatatttt tatatatttt ttcattctcc tcatctatag 3541 cttttttcaa attaatattt tcttttgttt cttttacttc atataatgtt tcttttgtta 3601 taaacaactt attattttct attctatcat atttttcaaa tttattgata gtttttttca 3661 aatatagttt tttaccctta aaattaatat atgtcctctc tattttttta cccgttcttt 3721 ttctttttat tctataggta tttatagttt taatttcttc ataaaaagtt ctagcaaaaa 3781 cctttccttc tgaatgaact tcataagttt cgccttcttt tccttgttca cctttaatta 3841 aaatatcacc tttttttact atgtctccat tttgtactat agcacttcct gaagtagtat 3901 ataccctttg tacttcacca tcttttttag ctactaaatc acaaggttca tcctccttaa 3961 ctatagttgg aggagactgc ctctcttcag cctttactac aagtttccct ccctcaattc 4021 tagcttttac ccacattata ttatctatat ccttaatcag tttttcttct aacttataaa 4081 catctatagt atttttattt attccaggct ttatcccata tttttttaat tgttgtctta 4141 tttcataagg tgttacacca ttagttgatg ttatatctat atcccatata aatgtagaca 4201 taaaatatat tataaaagaa aaaataaata tacctattac caatgagaac cttcttttta 4261 aaaataaaat aagaaaagag attccttttc tttttactat tgttactttt gttcctgttc 4321 tcctagctat attctccata acagcataat cttttaagtc tatatccaga acaaatgtag 4381 ttacatttgt cttaactaca tttttaactt ttacaccatt tttccataaa aggttaataa 4441 atctctctgg tatcatagat tgaatttcta ttgttatatt agcattttta tacttatcaa 4501 atttcattta cttcagaccc ttcatattct atagatttaa attttcctcc taaagtaata 4561 gtacttcctc ccataaacaa tatctcaaaa tcttttccat aaatagatat caatccagat 4621 ccagaattaa ttttcactac tttttcttca aaaacaacta ctcctctatg attttctatg 4681 cttatttcct cattacctgt aactattatc tttggctgat ttaaaattat atctcttggt 4741 aggtctaatt tattcgctac agtttccttt gcattataaa atctcttacc catttttcac 4801 ctcaaataaa aaaatacttt catattaatt tatgaaagca ttttttaata aatgacaaat 4861 gagtctatgt atataatata aaaagctgag ttttactcag cttttactat ttactcaata 4921 tattttttac tttttcactt acaagtttac catctgctct acctttagtt ttagggataa 4981 ctatactcat gacatttttc atatgtttca tgctatttgc accagtttca ttaactgctt 5041 tttcaattat ttctgtaatt tcctcttctg tcaactgctg aggaaggtat tttagcaaaa 5101 cttctatttc aaaattagtt gcatctacta agtcttgtct gtttcccttc ttgaagtctt 5161 ctaacgcttc tttgcgttgt tttatctctt tagatagaat atctattatt tctgaatctt 5221 caagagtttt ccctgaattt ttttctgcta aaagaatggc agctctaacc atgcttatag 5281 tactagcttt ctctttctct ttagctttta aggcttgttt ccagtggtct tgtagtgttt 5341 ccttaagaga cattattatc taataccctc tttcaaagaa atctattaat tataactact 5401 taaattttct ctttcttgca gcttcagatt tctttttttt ctttacactt ggcttttcgt 5461 agtgttctct ttttcttact tcagataaaa caccagctct tgcacatttt ttcttaaatc 5521 ttcttaatgc gttttctaat gattcatttt ctccaacttt tatttctgac atgttttctc 5581 cctccctccg ctagttcaat ttagtaaaaa caaagcagtt aattgcgggc taaataacac 5641 actagctatt atacaacata ttttgggaaa ctgtcaacaa cttaatattc taaccttaat 5701 aagttttttt aacctggtgg ccattgtaaa ttcctacctg caatcaggtg aaaatgtata 5761 tgaaaaacag tctgtcctgc tgattcaccg cagttagaaa ctactctata gccttcttct 5821 gatatattaa gatccttagc tattttttta gctaccataa atatatgact tataacctta 5881 ctgttttctt ctgttaattc atttagagaa cttatatgtt ctttaggtat tataagcaca 5941 tgatgtggtg ccactggatc tatatcatta aaagcatata ccaattcatc ttcatatact 6001 ttagagcttg gtatttctcc cttcaatatt ttacaaaaaa tacaattttc cattatatca 6061 cctcctgtta agtgaaatat tcaataaata gattaaaaat ccttctactc taataaattt 6121 ctcctttaat aaaatcctta gaaacttctt tcagcgtggt atttattatt tccccagtaa 6181 tatcctttga gcttttagaa tatatcttta tgtaatttgg agtatatcct tcaaaaattc 6241 ctttttcttt agtttcctgc tcatataata ccggcatttc tttttcaata aatttattca 6301 taaattcttt ttcaaggtct ttatctaaat ttattatttt attacttctt tcttctttta 6361 ttttaccatc tacttgattc ttcatttctt ctgccctagt accttttctt gggctaaatt 6421 taaatacatg cattttagac agttttatac cttttaaaaa ttcataggtt ttattaaact 6481 cttcttctgt ttctcctggg aaacctacta ttatatctgt agttatagaa acagattcta 6541 tatttgtcct taaattatgc actatctctt tatactgctc tacggtatat tttctattca 6601 ttctttttaa agtttcgtta catccactct gaagggacaa atgaaaatgt ggacagaatc 6661 tttttagttt acttattcct attatttctt cttctgtaaa aaaagttggg tctatagaac 6721 ctattcttat tctttcaata ccttctactt tatctatctc ttctaatata gatgttaaat 6781 tatactttcc ctctaaatca aaaccatagg aagctatgtc tataccagat aaaattattt 6841 ctttaaatcc atgcttagaa agtttttcga cctcttccat aatcttttct ggttttttgc 6901 tacataccgc tcctcttgca aagggtatta agcaataaga acaaaatcta ttacatccat 6961 cctgtatttt taaaaaggct ctagttttat ccctatactc ttctatattt aattcttcaa 7021 attctttgtt tctaagaaca tctttaattt ctattacttg atttttttct tccatagctc 7081 tatttaccca ataaactata tcacctttat ttctagtacc taaaactaca tctacgccat 7141 ctattttaga tacttcttct ggagctattt gagaataaca acctactact gcaattatag 7201 ctttagaatt ttgtcttctt cctctactta tcatctgtct tgatttttta tcacccatat 7261 tagtcaccgt acaggtgttt attacatata catcagccac ttcattaaaa tccactattt 7321 cataaccttg ctttataaat ttttctgtca tagcttctgt ttcatataca tttactctac 7381 atcctaatgt agaaaaagca accttcatta tatatttcct cctagatctc ctaattcata 7441 tgaaattatt gaagcacata ctatacctgc tgtttctgtt ctaaatattc taggtcctaa 7501 agttactatc tgagctttta tttcttctaa agctcttatt tcactttctt caaagccacc 7561 ttctggtcct attattatac ctatattttt aatattttct ttttcatatt ctatattttt 7621 tataagagac tttataccgt aattttcttt gctttcataa ggcacaacta ttaaatccat 7681 cccctttgtc tcttccaata aatcattaaa ttttagaggt tctctaacac ttggaattaa 7741 agatctttta cattgcttac atgcttcaag tgcaattcta ttccatctat ctaatttttt 7801 aaattccttt aatgaagctt taacctcaac tctttctgtt ataacaggta ttatttcttt 7861 tatacctaat tcggtagact tttgaactat taaatccatt ttagtagatt taggaagacc 7921 ttgatataaa taaatattta aagggttttc attatttact tcaacctgtt ctaatatctt 7981 tacaacaaca gattttttat ctatgctttc tatttcacct ttatattctt ttccctggca 8041 attatttata tttatagcat ctccacattc taatcttaat actttatata tatgtttaac 8101 atcatcccca tcaattatag ctttttcatc aattatattt tcagcgggta caaaaaattt 8161 atgcacaata atcacctact ttaacatttt tttataaagg gagccctaaa tataaatttt 8221 tatattccaa aaatacactt tttataaaat tactaaaatg attttagttt attttagata 8281 ctatacaaac ccattctccc tcttctctta cttcttctat tacaaaacct gtttcttcta 8341 actttttaat aacatcctct tttcttgaat ttattatacc agaagctata aagtatccgt 8401 ctttttctat aaaagctttg acaccctctg ttaaaaatat tataacatct gctattatat 8461 tagctactac tatattagct ctcccctcta caacttccat taaattacct tctaatattt 8521 ctatattgtc taaattgtta tatttaatat tttctttaga ggatttaaca gctactggat 8581 ccaaatctac acctattaca tgtttagccc ctaattttgc tgctgctata gataatattc 8641 cagatccaca acctatatca aaaacagttc tatcttcttt tatatgtttt tctaaagcat 8701 ttatacacat tcttgtggtt tcatgagttc ctgtgccaaa ggccatacct ggatccaatt 8761 ctactattat ctcctcttgt tttttatcat aattttccca aatgggcttt ataactattt 8821 tattagaaac cttagttggt ttataatatt ttttccaatt attttcccaa tcttcttcat 8881 ttactttatg aacttctact aaaccttttc ctttatctat tccaaattga tctaagttac 8941 ttacagattt ttttatgtaa tctaaatact cattaaactt atcatcttct ttgtaatatc 9001 cctttactat agcagtatcc ttaactttta acaaagtttc atcaaaataa tcccaatctc 9061 caggatgctt ctttttaaac tcaatatctt taggatcttc tattgaaact ccttttacac 9121 ctgtattgta taatattcct gatatagcct ctaaagcctc gctacttgta tatatacaaa 9181 cttctaacca ttctttatcc atgaaaaatt cctccttaaa ataagaaact actattagtg 9241 aactattcct tttaagcaaa ctctacttgt gaaactaaaa atcacttcat aaacagagtt 9301 cttggcttca gagggagttt ttactccccc tgaagcttat taacagaatt cttaggagtt 9361 ttactcctta aaagtcgtta tcctttaggg gaaatcgtta tccagggacg tagccgctct 9421 ctactcccac tttgaagaag atgggagtat tagagcgggt agtcatcgga taaaattttc 9481 taacactatt aatatattat acctaaaaat ccgaaaatcc accacaaaat ataaggaaag 9541 tgcgttgcac tttccttata ttagtctttg aacccttttt ttatcttctc aaaaatagta 9601 cctttttctt ttccttctac agtttcccca ctagcttcca tatacatagt tagagcttcc 9661 ttttgcttgc tatttaattt ctttggtata tctactatta tagtaacata ttgatttcct 9721 ctagctgtac tatttattct tggtactccc ttacctttta gcctaaatac agtccctggc 9781 tgtgttcctg ctggtacttc atatttaacc tctccatcta ctgtaggtac ttttatttcg 9841 acacctaaag cagcttgagc aaaacttata tgcttttcta tataaatatc gaagcctttt 9901 ctcttaaagg taggatggga agctactctt atatttatat ataagtctcc tgttggtcct 9961 ccattgtttc ctggttcacc ttgtcctctt agtggaatta catttcctgt atctacccct 10021 gctggtacgt taactttaat ctttttattt tttctaattt tacctttacc atgacattta 10081 ttacatggat tttctataac ttttccacta ccaccacatt tgtcgcagga agtttctgtt 10141 accatacttc ctaatatagt gttcttttga attctgattc ttccagtacc accacattta 10201 tcacagtctt taggacttgt tcctggtttt gcaccagttc cattacaatt atcacaattt 10261 tcatgtttgt ttacagatat ctctttttcc gctccaaata ccgcttcttc aaaggttaaa 10321 tcaatagcag tttctatatc cgcacctctt tgaggtccat tttttcttct tccaccagaa 10381 gaaaatcctc ctccaaagaa ggaatcaaat atatctccaa agcctcccat atctgaaaaa 10441 tcgaagcctc caaagcctga tgaatcaaat ccgcctgctc cgttaaaatc tgtagttcca 10501 aattgatcat attgagcttt cttttgagga tctgaaagta cctgataagc ttcatttatt 10561 tctttaaatt tttcttcagc ttctttgttg cctttatttt tatctggatg atattttata 10621 gctaactttc taaaagcttt ttttatatct tgttcactag cacctttttc taatccaagt 10681 aatgcataat aatccttgct aggcattcct ctttttcacc acctaatatc taattgaatg 10741 taatctaaaa ttgtttttgt acttaaatta agggaggagt acaaactccc tcccttaatt 10801 catacctatt atatattata caatttttta gtatttgtca tttatttttt atttatcatc 10861 ttcaacttta aaatctgcat ccactacatt gtcatctttt ttatcatttc ctgctgaagc 10921 attacctgca tttgctccac ccatattatt aggatcaaag cctgcacctg gcgctccttc 10981 tggattagct tgttgatata tctttgaaga tattccatag aatgtttgag ttaaatcttc 11041 agttgctttc ttaatagctt ctaaatcttc tccatcttta acatccttaa ctacttttac 11101 tttttcttct atttgagctt tatcttcagc tgacacctta tctcctaagt cagttaatgt 11161 tttttctgtt tgatatacta tttgatctgc attgttttta acttctatag attcttttct 11221 ctttttgtct tctgcttcaa atttcttagc ttcatttaca gctttttcta tttcatcatc 11281 tgttaaattt gttgaagctg ttattgttat attagcttct tttcctgttc ctttatcttt 11341 agcagatacg ttaactatac cattagcatc tatatcaaaa gttacttcta tttgaggtat 11401 tcctcttgga gctggagcta ttcctgacaa agtaaatctt cctaatgttt tgttatcagc 11461 tgccattgat ctttcacctt gtactacgtg tatttcaact gatgtttgac cgtctgctgc 11521 tgtagagaac acttgactct ttcttgttgg tattgttgta tttttttcta ttaacgtagt 11581 tgaaactcct ccaaatgttt ctattcctaa tgttaatgga gtaacatcta aaagtaatac 11641 atccttaact tctcctgtta aaactcccgc ttgaatagca gcacccattg caacaacttc 11701 gtctgggtta acccctttac ttaactcttt tcctgtaaag tccttaactg catcttgaac 11761 agctggtatt cttgttgatc cacctaccat tattatttta tctatatcag acattgcata 11821 tcctgaacct tctaatgatt ttttaattgg ttctaatgta cgttgtacca aatcatgagt 11881 taattcatta aatttagctc ttgttaagtt catgtctatg tgttttggac ctgttgcatc 11941 tgctgttata aatggtaaat ttatatttgt ttgtgttgct gatgataact ctattttagc 12001 tttttctgca gcttctttta atctttgtat agccatttta tcatttctta gatctattcc 12061 attttcagct ttaaatgttt cagctatata atctattaat ttttggtcaa agtcatctcc 12121 acctaatttt gtatctccat tagtggcttt aacttcgaat actccatcac ctagttctaa 12181 tattgatacg tcaaaagtac caccacctag gtcataaact aatatttttt catttgtatc 12241 cattttgtct aaaccataag ctaatgatgc agctgttggt tcatttatta ttcttaaaac 12301 ctcaagccca gctatttttc ctgcatcctt tgtcgcttgt ctctggctat cattaaagta 12361 tgctggtact gttataactg cttgagttac tttttctcca agatatgcct ctgcatctgc 12421 ttttaatttt tgaagtacca tagctgatat ttgttgtggt gtatattctg tgttatctat 12481 attaacttta tggtctgttc ccatatatct tttaatagaa attatagtct tttctggatt 12541 tgtaatagct tgtctttttg ctacttgacc tattagtctt tctccattag cttgaaaaga 12601 tactactgaa ggagttgttc ttgaaccttc tgcatttggt ataactactg gttctccacc 12661 ctccataact gatacacaag aatttgttgt tcctaagtca attccgatta tttttgccat 12721 tttaatattc cctcctagtt tgtaatttgt taggttttta taataaattt ttatctagtt 12781 tgctactttt accatactat atcttataat tttttcacct tttttatatc ccttttggaa 12841 tacttctact atttcttttt ctccacaatt ggaatcctcc acatgcatta ctgcattatg 12901 aatattagga tcaaaagcaa cttctgtaga tatctcttct acccctaatt tttctaaaga 12961 agttccaaac tgtttaactg tcatgtctat acctttttta atatcttcta cagaaccttc 13021 tacgtttgct gctctttcta aattatctaa aactggaaga agttctttta agacatcttc 13081 acaggcacta acatataagt cttctttttc tttagctgtt ctttttctaa aattatcata 13141 ttctgctact gttcttacta atctttcctt tatttcttcc atctgatttt ctaatttttt 13201 attctcttct tttaatttat ttttcatatc ttctaattcc tttatcttta cttcattaga 13261 gtcttcagag tcctctatta tttcttcttt ttctatttct tcaaactcta aatcctcttc 13321 tttaccttta tcttcttctt tattttcact ttctttatta gagcagcagc aatcctcttc 13381 catattaata tgtttagcat ccttgcattc tttttccaat tatatacctc cattctatcc 13441 gcttgttatt tatgaatatt tttgtcatta gttaaggtat catttatttc cttaactatt 13501 gtagccacag ctgatattat tttttcataa ggtattcttg taggtcctat aactcctata 13561 gttcctatgg gtgtctttcc tatactatat actgctgaaa taacactaca ttgttttgca 13621 tcttccacaa aattttcttt tcctattttt acagcaatat cagaatccgc atataataat 13681 tcttctacct tttctctatc atttaacata gatagaaatt ctttagctct atctacatca 13741 ttgtactcag gataattgaa tatatttgtg gttccttcca tatatatttc tgcatcctct 13801 atgtccgtaa gcgcttcata tatagaggat agaatatttt ttaatatatc accatatcct 13861 gtcatttctt tttttaattc gtttaataat tctaaattta cttctcttag atttagtcct 13921 tttaattttt ggtttaataa attatttatt tttattaagg agccttcatc tatttctttt 13981 gttactctta atagcgtatt ttttatcatg gcattatctg ttataacaat caataataaa 14041 ttatacttat caaccttaat tatttgtatt gatctcaatc tactttttat catagaagga 14101 gttttcacta aacaagttaa tttagtgatt tcagataata tacttataga atgtcttatg 14161 gttttatcta tttcatataa ggctgaatct atagcttgat cctttatgag cattttttct 14221 tgctctgtta gagctgttaa tatcataagt ttatctacat atagtctata gcctttatct 14281 gatggttttc ttccagatga actatgaatc tgttctaaat atcccatatc ttctaggtct 14341 gccatctcgt ttcttatagt tgccgaactt actcctaaat catatttttt agcaatagtt 14401 cttgatccaa cgggttctcc actattaata taatctttta ttatagcttg aagtatcctg 14461 atttttctct catccatatc atattgacac ctcttttatt agcactcact cgcaacgagt 14521 gctaattact atgattaaaa tctaacattg tacaaattat ttgtcaacct atctatttga 14581 tatttaactt tgtttaacct ttatattttc aaaaaattta tattaaattt taaaaatctc 14641 actttttctt agaatttctt tatttttctt ttaaccctta taataaaaaa tcggaaagta 14701 tagtatttga aatacttacg gcctctttag ataaatatat cctgttttcc ttttctatta 14761 ataaatttaa ttttttatat ttattgatta cacttccata tatgtatatt atatttttac 14821 caaatctcac ctgaaaatca tctatacata taccttttgt ctttctaagt cccataaaca 14881 taaactcttc catattttct ttttgtgaat taatatgaaa atttatctga gtaagattat 14941 tagagtttat ttcttttata tatgtttcta tagaactagt attttcatat cttcgattat 15001 ttacataaga atgagcacct actccgcaac ctatataatc ttccaaatcc caatacacta 15061 gattatgtct acactcttta ttaggattag caaaatttga aatttcatac tgtaaatatc 15121 ctctttctct taaaaaatca atacaatact catacatttc tctttcttct tcttctttgg 15181 gaagtttcag caatgagttt ttatataaat tataaaaatt tgttccctct tcaattatta 15241 aactataaca ggataaatgt tctggactta aatctactac tgtaagcaaa gtatccttcc 15301 aatcatctaa actttgattt ggaagagcaa acattaaatc cacatttata ttgttaaatc 15361 cctcctttct agccatttta aaactatgta caaaatcctc aaaactatga attcgtccta 15421 atgtttttag tagactattt ttagaacttt gaagccctat acttagtctg tttactccca 15481 ttgattttag catctttagt tttttctctg taaaagttcc cggattacct tctactgtaa 15541 attctatatt ttctttttta tctatagttt tcaaggtgtg ttttaaaata tttaaagcct 15601 ctaaagataa ataggtggga gtacccccac ctataaatat tgtttttatt atcttgtttt 15661 ttgtattatc aacaatttct ttagagaggg ctttaacgta ttccatcatt aaatcttctt 15721 ttttactata agatgtaaaa tcacagtatg aacatttttg catacaaaaa ggtatgtgta 15781 tatacaatga aacttcctta tttttatcct ctctatccaa acctaacact cctaagttat 15841 atattattat tcctctgttt ttaatactgc cataaatgct tcctgtggta cttctacaga 15901 tccaacttgt ctcattcttt tctttccttc tttttgtttt tctaaaagtt ttctttttct 15961 tgatatatct ccaccataac attttgcaag aacgtctttt ctcatagctt ttattgtttc 16021 tctagctatt atcttagctc ctactgctgc ttgtattggt atttcaaaca tttgtcttgg 16081 tattatttcc tttagctttt gggccatatt tcttccctta gcataagctc tttcccttgg 16141 cactatcata gacaaagcat caacaatatc tgcatttaat aatatatcta attttacaag 16201 atctgcatct ttatatccta ttaattcata atcaaaggat gcataacctc ttgtccttga 16261 ttttaaggca tcgaagaagt cataaattat ctcatttaaa ggtatttcgt agtttaaaga 16321 tactctagta gtatctaaat attgcatatc tttaaatatt cctcttctat tttgagctaa 16381 atccataact gctcccacat aatctgatgg tgttattata gatgacttaa ctataggttc 16441 ctccataagc tttatttctg aaggacttgg catattagtt ggatttgtta actctattaa 16501 agttccatct gtttttgtta ttttgtatat aacagatgga gctgtagtta taatatctaa 16561 attaaattct ctttccaatc tttcttgtat tatatccatg tgtaagagac ctaaaaatcc 16621 acatctaaat ccaaaaccta aggctataga agtctctggt tcaaaggata atgctgcatc 16681 atttacttga agcttttcta aggcttcttt taattcttca tatttggctc catctactgg 16741 atatatacca ctaaatacca ttggcactgc cggtctatat cctgataatg cttcattagc 16801 agatctctta gcttctgtta tagtatctcc cactctggca tctctaacat ttttaattga 16861 tgcagttaca tagccaacat ctcctgcttt taattcatct acaggcatat agtttggtac 16921 aaaaactcct acttctacta cttcataaac ctttcctgta ttcataagtt ttatttctgt 16981 gccctctttt attgtgccct cttttactct tatatgacaa actactcctt tataactatc 17041 atagtatgaa tcaaatataa gagcctttaa aggggctttt tcatctccgt ctggtgctgg 17101 taccttattt actatagctt ctagtgcatc ttttatgttt aatcctgttt tagccgaaac 17161 taaaggtgca ccttctgctt ctatacctat tacatcttct atttcctgtt ttacttcttc 17221 tggtctagca cttggtaaat ctattttgtt tataacagga actatttcca aatcattatc 17281 taaggctaag tagcaattag ctaatgtttg agcttgtatt ccttgtgttg catctactac 17341 tagtatagct ccctcacaag ctgctaaact tctagaaact tcatagttaa aatctacatg 17401 tcctggggta tctattaaat taagtgtata ttcttcccca gtatcccttt tataaattaa 17461 tctcacagct tgagacttta tagttattcc tctttctttc tctaagtcca tattatccaa 17521 tacttgtgta tccatttctc tttctgtaag cgttcctgtt gcttctatca atctatctgc 17581 taatgtagat tttccatgat ctatgtgtgc tactattgaa aaatttctta tatatttttg 17641 tctttcactt tgcattatat ctttaccccc aaataacata taggttttta ataacaaact 17701 ttcaactcga aaattgtaaa aataatcact gtaaattata acataaaact ccggtgatat 17761 gtcaactgaa aggtgaaatc cctagttatt tattattatt ttacacctct tccattaaaa 17821 actcctagca cttcctcttt tattttataa aacacactcc ctattttatt taaactatga 17881 cttctattaa tattgtttaa aaaattactt gtagaatttt tcatattatt aaaagtttta 17941 taggttttat ctcctatatc atttaaaatt ttttcattta tataaaatgt atagctttcg 18001 gttttgaatc taatatccaa tggcttttta gtaaaataaa tagctacttt tgacctatct 18061 tttacaaatt taggtatagt attgcttaca ataaaaaatc cacttatagt tattaaaaaa 18121 cttaataata taactgtttt atatttgttc caatttaatt taaattttct tttctttttt 18181 attatttcca t //