LOCUS NC_012658:7 19139 bp DNA linear BCT 04-SEP-2013 DEFINITION Clostridium botulinum Ba4 str. 657 chromosome, complete genome. ACCESSION NC_012658 SOURCE Clostridium botulinum Ba4 str. 657 chromosome, complete genome. COMMENT locus start: 1052957; locus end: 1072095 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.183659; n0_4mer:D = 18.743920; n0_4mer:PS = 23.979778 FEATURES Location/Qualifiers source 1..19139 /organism="Clostridium botulinum Ba4 str. 657 chromosome, complete genome." gene 1..2160 /gene="" /locus_tag="" /db_xref="1052957..1055116" CDS 1..2160 /gene="" /product="putative phage infection protein" /translation="MKKVFRIFSRDLKNIVKHPAAIIVVLGLCFIPSLYAWINIEACW DPYANTGNLPIAIVNKDEGMMVRGKYTNVGNGIVESLKGNKKMGWVFVDEWQANYGLN EGKYYALIEIPSNFTSGLASLKTTDPQKPNIIYRVNEKSNAIATKITNAAKGSLAKEI QTNFVYTVNKEAFKLLNNTGGQLEKNKSKILGIKSTLELGNKSIGEVKNIIDDASKDS ESLKQYFNDTKDKLPLITDQINNLQKATEASKNLVNETERDLNGIAKNINNDMIYRES TNSKINSILTNLKEYNNVSNNSEMIKLVDEASKLCDSINSNIDGTIKSLEIVNILKPN KIIEELINSLKNLQEKVNGEKNKLTELKNKISTSNNNKQNINQVVESILLLNDEINKN MRNTSNIFYNQTTMIIENTAKGLNNRLDTANDILDTTKLVIPQLKALGDFGVGTSDAA LKDGKKINNKLAEFKKTINKLEEKTSSLTEDNLDKIINLTQKNPEQMASFISSPINIK EEEIYNTGIFGVGLTPFYTVLAIWVGVLLMSSLISVEAEEFEGEKKLTHLQVYFGKLL LFLSIAIIQGIIVTLGDVFILGIKPASMGLLMVFTIVTAITFTFIIYTLVSIFGNLGK AIAVVIMVFQIAGAGGIYPIQTNPKIFGVLQPLWPFTYAIAGFREAIAGPVRAAVIKN LGALFIFSIGSLLLVVLKKPLHKVTEYMNDKFIETGL" gene complement(2785..3087) /gene="" /locus_tag="" /db_xref="1055741..1056043" CDS complement(2785..3087) /gene="" /product="hypothetical protein" /translation="MEKKPSVKRSATLLAIVSLIVSIIVILPILNWLFKITPWQKWEG LPLFFGIFISPLGFLLGILSVRIETNKWGKLGIVVNTLLFLLPFIYMTLGVLIFGP" gene 3293..4048 /gene="" /locus_tag="" /db_xref="1056249..1057004" CDS 3293..4048 /gene="" /product="hypothetical protein" /translation="MPFTFSHPAIVLPLEKKWNKYFSFTALILGSMSPDFEYFIRFKP MATIGHGLIGFFLYNLPLCFILAYLFHKIIKKPLIAHMPKPIDSWYYNTALKPWRINS LTQVLVFSYSAIIGMITHVLWDSFTHKGGKFVILFEGLRKNIEILNYDIPVYKTLQHG STLLGVIFIILYIYSKRNKHINWKRINRIPAINNKEKVSYFTTIFCTGLIVLFVYIFL LNVSFSIKNVGSFVVTFINGLFIGAIITSIKCR" gene 4294..6423 /gene="recQ" /locus_tag="recQ" /db_xref="1057250..1059379" CDS 4294..6423 /gene="recQ" /product="ATP-dependent DNA helicase RecQ" /translation="MLEGAKDLLKKHFGYNEFRKAQEKVIESIIKKEDTVAIMPTGAG KSICYQIPALIFEGVTVVISPLISLMKDQVDSLKEVGIEATYINSSLNNLEIEERIFN AREGIYKLIYIAPERLESDSFVRSLNNLNIALVAVDEAHCVSQWGHDFRPSYTKISNF IRKLSKRPIVTAFTATATEAVRKDILNSLELQNPKVFVTGFDRENLSFSVIKGEDKEK FIFAYLGNNIGKVGIIYTSTRKEAESLYNKINKKGYKVGVYHAGLNDEERKKTQEDFS FDNIEIIVATNAFGMGIDKSNVRFVIHHNIPKNMEAYYQEAGRAGRDGEESECILLFS PNDIRLQKYFIDESFLSPERKNNEYNKLRAMVDYCYTSKCLRSYILEYFGEDALEEKC NNCSTCNDNREEKDITLEAQKIFSCVYRMKERFGVNMVADVLRGSKNKKLLSLDLDGV STYGIMEEFTQKDIVALMNKLIADDYMVTTDDKFPVVRLRPKSYDVLKGKEIVSIKVS KIEKKVKVDNELFEILKQLRKEISQEESVPPFMIFPDATLKELSEYMPTKEEDLLKIK GIGERKAKVYGERFIEAITEYMNEKGIDINNMDNYESTKSNKESKIKTHVLSYNLYKE GKTIKEIAEERNLKAITIQEHLFKCLSEGMEVDLDNFIKKDYEKLILDTIKKVGGTKL KPVKDELPPEVDYMCIKSVWYKYKDII" gene 6534..6965 /gene="" /locus_tag="" /db_xref="1059490..1059921" CDS 6534..6965 /gene="" /product="rubrerythrin family protein" /translation="MDELDIINENQLGIAAENEKIKTDLEGQFRAETGEVGLYIAMAR VAQRQGFPEIAEVLKVIAKEEAEHAARYAELNGKVSDCTKENLQKMLQGEIGSNKMKK SLAVKAKEENIDEVHDFIDEASRDEARHAKMLKGLLDRYFQ" gene complement(7199..7744) /gene="" /locus_tag="" /db_xref="1060155..1060700" CDS complement(7199..7744) /gene="" /product="phosphodiesterase" /translation="MKLFFMSDIHGSAYYLEKALHIFEEEKADYLIILGDELYHGARN PLPKEYDPKKVTEILNCYKDKIIAVRGNCESEVDQMVLNYPIMSDYSIILYNGKRLFL THGHIFNKDNIPNISDGDALIYGHTHIPLAEKINNIFVINPGSITFPKENTPHCYGIL SDNLFKIKTLEGNTFKEISLI" gene 8383..8766 /gene="" /locus_tag="" /db_xref="1061339..1061722" CDS 8383..8766 /gene="" /product="response regulator" /translation="MSSSQKNILVIDDSASIRSFVRNILEKANYRVYEACDGEEGIEV YKKCGNIDLVMTDIYMPKKSGLEVVVELQNKYKGTKIIVFSDGGKENFTNDSGVCEAL GAAYFIRKDLIKDKLLDLVNIIFSK" gene 8881..11355 /gene="" /locus_tag="" /db_xref="1061837..1064311" CDS 8881..11355 /gene="" /product="KWG repeat-containing protein" /translation="LIERNLFNIINKYLPMGSQIIVEEDNNNEPLIIKANFNGYGLGE IIVAYRWKEENYIMVLERYCNQWGVIDNIRGKGYDISYLKVAPITDNAMDNLIIGWRR GAIWSELDILQWTPYGFKRVIDEGIYYSKIEVENMKSVKAMNGKNEIALWLHDTAEAY KVEIYRWSLGKLVKAEDVYPYYFKKVIDFYKTKLQEEPDLPVYWYYLADAQIKGEMYE DALKSIDKALELPKAYPSKKELIKLRDYILYYKKCKNINLYPAPMNTIKGVRWGYINE KGEFLIKPLYNLALEFQCNGLAVVEIDNLYGIIDENQNYIVKHKYGFISDFSEERAIV IDNERFNIINEKGEELIPKIENYSYIGSFKEGRAQYGVIDSNKGYLYGYLDREGRVII PAQYEYGNDFYEGKAVVRIKENEYALININGEILNKYEYASVGNLREGLLSFKKDMGE KYGFIDEDGNVVIKPQFTYAQDFSEGRSVVNVSGNIMNNYGVIDKEGNYIITPKYNDI ILLGENRVAVGVAIDKTSPFIGSKYAIADTEGNILTDFIYYEVSNYKNRIASAYDDKN TFFIDKEGNKIENLPIVEGSGTLTVQNELIKAYVDYKISYFDKEGNLIWEENSVISLN NQYKVIEEKYKPNKDYLVYYPKVQGMGDKVLEDEVNNRLKILSEVEPIEENVELEYNY LGDFKIEFFNKNLLELELDGYKFPFGAAHGMPSKIYTKIDLTTGEFYELKYLFKEDSD YVKVLSDIIGQQIKNNPEYSYIFPDSYNGIKEDQPFYVSQSALYIYFYPYEIAPYAAG FPTFKIPYEDIMDIINESGEFWMSFN" gene 11728..11943 /gene="" /locus_tag="" /db_xref="1064684..1064899" CDS 11728..11943 /gene="" /product="hypothetical protein" /translation="LTKQIKLRIYPDGIVQAEVEGVKGKKCTNYISIIENLLEAKVAD SEYTPEYYEEEVIESYEEDNITLKEGI" gene 11945..12766 /gene="" /locus_tag="" /db_xref="1064901..1065722" CDS 11945..12766 /gene="" /product="hypothetical protein" /translation="MAVTKKGDKWEIQKSLWIISSFVFLVNGMGMYFAGKKTKVRKWY NYGLIYTAIAWIGLIMGGELTGFLQSVGSIIFLLDYIICIIHSFKIRKEYLIRREILE DKNVEEQNKINFMRNKIAKEYGLDDINSNNTIKDNTSQNDLVRESSNINAEAKIENFD MKNKEENINNISPRMPKVENTVNNIKNNVNNEELLDINSCNELELSRLPGMGLILAKK AVNLRNSRNGFDSVDEFIEMVGVKPHFVDTVKTMICCNPVKTVETVKMSGRRVDF" gene 12766..13359 /gene="" /locus_tag="" /db_xref="1065722..1066315" CDS 12766..13359 /gene="" /product="putative anaerobic ribonucleoside-triphosphate reductase activating protein" /translation="MEIRIHRILPKTEVEGPGTRCCIWVQGCPIHCKGCGAKETWDFK GGELLDTNEVFDIIKNSKEIEGVTFLGGEPFAQASAVYDIALRAKSIGLTVLTFTGYT YDHILKSNKKEWNDLLSVTDLLIDGPFDEEKFDISRPWVGSSNQSYRFLTPSYKHLEN NLTSIKNKIEVRLHKDGAIFLNGMGDFNSIKNKLKNL" gene 13373..15046 /gene="" /locus_tag="" /db_xref="1066329..1068002" CDS 13373..15046 /gene="" /product="ATPase" /translation="MSMESSNNTERTKKYLANMFKARFPYVYITTWEEERAISVINSV AKDASIIKTPRTTYIWSQTNGMAIENLKGKEETKQPLKALEFIEKCEEPAVFILKDFH VFFGVQGKNIDYSLIRKVRDLVTVLKASSNPKSVVFLSPTVVLPNELQKDITILDFDL PTIDEIKSMLDEMIYVNEQSGRIDMDLNESEKEKICKAALGLTLQEAENAFARAMVED GKLNIDDIEVVLEEKCQVIKKTGILEFIKSDLKMEDVGGLENLKRWISKRNKSWLDSA QKYNLPAPKGVLITGVPGCGKSLTAKAISAMWQLPLLRLDMGKIFSGVVGSSEENMRK AIKTAEAVSPSILWIDEIEKGFGGASSSGDSGTSMRIFGTFLTWMQEKTKPVFVVSTA NNISNLPSELLRKGRFDEIFFVDLPTKNEREDIFRLHLKKRLTNEEVCEEISITEELL SNLADLTEGFVGAEIEQAVIAALFEAFSEDRALKVTDLERVIKNTVPLSVTQREQIIK IREWANVRAVAATAKEDRSEYLEVNEEKKDEKKREDDIKISRGGRTIDF" gene 15061..15831 /gene="" /locus_tag="" /db_xref="1068017..1068787" CDS 15061..15831 /gene="" /product="hypothetical protein" /translation="MSISLALVPAVLTLKVVMNEKDLDNWVENSKIKMPTTLINEEEI IKTLKQAGYKINKYKDLIKTEISGENEFITWEKENGIWNVVFSKYDSKEMIVDFIMNL NSKAGRKVIYKSIEEMENRNENSTTVEEILELPKVEKEIFPTNFRDKDLLLKTLKDCG ACPKEASNEDIQCNTKECQLIFHKGEDGSYNVEIEDTSSLKNVYHHLSIIDEEYKHNV QEYTYKKVVEKLNETDMYIDNEEVLEDNSILLTVNIGD" gene 16313..17836 /gene="lctP" /locus_tag="lctP" /db_xref="1069269..1070792" CDS 16313..17836 /gene="lctP" /product="L-lactate permease" /translation="MNMYLTCFIALVPIAWLMVSLGILKMPGYKTCPATLVLTAILAV IVWKMPILDAASAALEGTALALWPIILVIVAAVFTYNLSIHTKSMDTIKKMMTSITTD KRILVLILAWGFGGFLEAIAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFG GIGIPVTTLAKVTNIDVIQLSYAVGLQLSVLIVIIPIVLVMLTGKSVKSIKGVFGIAL ASGLSFAIPELLMAKYMGAELPAILGSITCMVVTIAMAKIFYKDTASKNVEKIPFKKA VIAWLPFILVFVFIILTSPLFPVINKGLSQIQTTLYIYTGAHAKPFTFLWLATPGTLI IIATFIGGLIQGAKFSEIVSVLVKTIKQMSKSAITIIAIVAMAKIMGYSGMIKSIAVV LVAVTGSYYPLISPIIGALGTFVTGSDTSSNVLFGGLQVEVAKTLGLNPYWLAAANTG GATAGKMISPQSIAVATAATGLVGAEGKILNATIKFCIVYVIVLGIMAYFMAPVFGF" gene 17865..19139 /gene="" /locus_tag="" /db_xref="1070821..1072095" CDS 17865..19139 /gene="" /product="hypothetical protein" /translation="MAKIKIPYHKKMIEIGIEDKNLVGILESKADEYKRNLSQEEIVE AALDNPIQCEKLEDLVKGKKNMVIITSDHTRPVPSKITMPILLRRIREVNPDIDIKIL IATGFHRESTKEELINKFGEEIVKNENIVMHVSTDDSTLVKVGKLPSGGELILNKLAM ETELLIAEGFIESHFFAGFSGGRKSILPGIASAKTIMANHCGEFIASPNARTGILKDN PVHKDMLYAAEKANLAFILNVVIDSEKKVINAFAGHRQYAHETGCKFVLELSKVEKVK ADIVVSSNGGYPLDQNIYQSVKGMTAAESTCKEGGVIIMVAACNDGHGGQSFYDNLAN SKSPRELLDRIAKVPRCETVPDQWEFQILARMLDKFTVILVTDMCDPNMIKAMHMEHA YNFEEALNRAYKLKGKDAKVAVIPDGVSVIVG" ORIGIN 1 atgaaaaagg tatttagaat attttcaaga gatttaaaaa atatagttaa acatcctgca 61 gccattatag tagtattagg attatgcttt atcccttctt tgtatgcatg gatcaatata 121 gaggcttgtt gggatcccta tgctaatact ggaaatctgc ctatagctat agttaataag 181 gatgaaggta tgatggttag gggaaaatat acaaatgtag gaaatggcat tgttgaaagt 241 ttaaagggaa ataaaaaaat gggctgggtt tttgtagatg agtggcaagc aaattatgga 301 cttaatgaag gtaaatatta tgctcttata gaaatacctt ctaattttac tagtggacta 361 gcaagtttaa aaactacaga tccccaaaag cctaatatta tatatagggt taatgaaaaa 421 tcaaatgcca tagcaactaa aataaccaat gcagcaaaag gaagcttggc taaagaaatt 481 caaaccaatt ttgtttatac agtaaacaaa gaagctttta agttattaaa taatacaggt 541 ggtcaattag aaaagaataa atctaagata cttggcataa aatctacttt agagcttgga 601 aataaaagta ttggagaagt aaaaaatata atagatgatg ctagtaaaga ttcggaaagc 661 ttgaaacagt attttaacga tacaaaggac aagctaccac ttataacaga tcaaataaat 721 aatctacaga aggcaacaga agctagcaaa aatctagtaa atgaaacgga acgagattta 781 aatggcatag caaaaaatat taataatgat atgatatata gagaaagcac aaatagtaaa 841 attaatagca tattaacaaa tttaaaagag tataacaatg ttagtaataa ttcagaaatg 901 attaaacttg tagatgaagc atcaaaatta tgtgattcta taaatagtaa tatagatggg 961 actataaaat cattagaaat agtaaatatt ttaaaaccta ataaaataat tgaggaatta 1021 ataaatagtt taaaaaattt acaagaaaaa gttaatggtg aaaaaaataa attaactgaa 1081 ctaaagaata aaatttctac ttcaaataat aataaacaaa atataaatca ggttgtagaa 1141 tctatattgc tattaaatga tgagataaat aaaaatatga gaaatacatc taatattttt 1201 tataatcaaa caactatgat aatagaaaat actgctaaag gattaaacaa tagattagat 1261 acagctaatg acatattaga tactaccaaa ttagtaatac ctcaactaaa ggctttgggg 1321 gattttggag taggaactag tgatgcagct ttaaaagatg gaaaaaaaat aaataataaa 1381 ttagcagaat ttaaaaaaac aataaataaa ctagaggaaa aaacatcttc tttaactgaa 1441 gataatttag ataaaataat aaatttaact cagaaaaatc cagaacaaat ggcttcattt 1501 atatcttctc caataaatat taaagaagag gagatatata atacaggcat atttggagta 1561 ggattaactc cattttatac agttttagct atatgggtag gagttctatt aatgagttca 1621 ttgatatctg tagaagcaga agaatttgag ggagagaaaa agcttactca tcttcaagta 1681 tattttggaa aattgctttt atttttatca atagctataa tacaaggaat tattgtaacc 1741 ttaggtgatg tatttatttt aggaattaaa ccagcaagta tgggattgtt gatggtattt 1801 actatagtaa cagctataac tttcactttt ataatatata ccctagtatc tatttttgga 1861 aaccttggaa aggctattgc agtagttata atggtatttc aaatagctgg tgcaggggga 1921 atatatccaa tacaaactaa tcctaaaata tttggtgtat tgcagccttt atggcctttt 1981 acttatgcca tagcaggatt tagagaagct atagcagggc ctgtacgagc cgctgtaatt 2041 aaaaacttag gagctttatt tatattttct ataggctcat tattattagt tgttcttaag 2101 aagccgttac ataaggttac tgaatatatg aacgataaat ttatagaaac aggattataa 2161 ggatgttacc attttaaggt aaatttatta cagcctatta aaaagggata tgtgtctaga 2221 aaggcaactc aattcgctaa gatattttaa tttgtttttt ataaaatata ttggtaaaaa 2281 atgaaactca ctgaccgctc aaacaatcat tttttcccta atatatttta taaaaaaata 2341 acaatatcta agctttttca aatgcctttt acgccacata tccctatttt taataggctg 2401 aagttaatta acttttaaaa aataattttc tgtgaaccaa gggctaaata aaagtcctgt 2461 ttactttacg cttaaatatt agttcacaaa taaagtattc taattatttt tctagatatc 2521 tattttctct aaaagtattt tttgttttaa tacctttaaa ggttattata ataatttctt 2581 actgagagga aaacatgcaa aaggatgatt ttgttccgct tctttacgca gaataaatgt 2641 tttttatatt acatatcttt attttttaaa ccaaggaaaa ctatcatagc tccttaaaga 2701 taatttccag tgaggaaaga caggtataaa agagagcttt tattctattg tatttatgta 2761 aaattcataa ttagtaatta agcatcaagg tccgaaaatt aaaaccccta aagtcatata 2821 gataaaaggt aatagaaata ataaagtgtt aacaacaata cctagcttac cccatttatt 2881 agtttcaatt cttactgata atattcccaa aagaaagcca agaggactta taaatattcc 2941 aaagaacaaa gggaggcctt cccatttttg ccatggagtt attttaaaaa gccaatttaa 3001 tattggtaaa ataacaatta tagacacaat taaagaaaca attgcaagta gagtagcgga 3061 acgtttaact gaaggctttt tttccatata actatactcc ttgtatttat taatttatat 3121 ttgaattata cattatatat ggtttaaaaa gccagatttt atttttatat tttataaaat 3181 tatattttta taatatgtta aaatagacta tatttataaa agctaaaaat tagttgactt 3241 aataaaaata attataataa ataattatat agattttagg aggatagaaa taatgccctt 3301 tactttttca catccagcaa tagttttacc cttagaaaag aaatggaata aatattttag 3361 ttttactgcc ttaatattag gtagtatgag tcctgatttt gaatatttta taagatttaa 3421 acctatggct accataggac atggattaat aggtttcttt ttatataatt tacccttatg 3481 ttttattttg gcttatttat ttcataagat aataaaaaaa ccattaatag ctcatatgcc 3541 taaaccaata gatagttggt actataatac tgcattaaaa ccatggagaa taaattcctt 3601 aacacaagtt ctagtattta gttactcagc tattataggt atgattactc atgtactttg 3661 ggatagtttt acccacaaag gtggaaaatt tgttatacta tttgaaggat taagaaaaaa 3721 tatagaaatt ttaaattatg atataccagt atacaaaaca ctccagcatg gaagtacact 3781 tttaggagta atatttataa ttttatatat ttattctaaa aggaataagc atataaattg 3841 gaaaagaatt aatagaattc ctgccataaa taataaagaa aaggtatctt attttacaac 3901 tattttttgt acaggcctaa tagttttatt tgtatatatt tttttattaa acgttagctt 3961 ttctataaag aatgtaggat cttttgtagt aacttttata aatggtttgt ttataggtgc 4021 cataattaca tctataaaat gtaggtgaaa attttaaaat acttttttat agaaatattt 4081 aaagaaagtt gggtataatt ttagacgagt aaatcaatgt aaatttctta ttaataaagt 4141 tatactaaaa ttatatttta ggctatgttc cgacagtgat tatataaaat ataagaattc 4201 taaacaatta agactcaaca tttacaagac ttccgatttt atagaatatg ggagtattat 4261 aaatgagata atatatgaaa tggaagtgaa tttatgttag agggcgctaa agatttacta 4321 aaaaaacatt ttggatataa tgaatttaga aaagctcaag aaaaagtaat agaaagtatt 4381 ataaaaaaag aagatacagt agctattatg cctacaggag caggaaaatc aatatgttat 4441 caaatacctg cattgatttt tgaaggagta acggtagtaa tatctcctct tatttctctt 4501 atgaaagacc aagtagactc tttaaaagaa gttggaatag aggctacata cataaatagt 4561 tctctaaata atttagaaat agaagaaaga atatttaatg caagggaagg gatttataag 4621 cttatttata tagctccaga aagattagaa tctgatagtt ttgtaagaag tttaaataat 4681 ttaaatatag ctttggtagc ggtagatgag gcacattgtg tatctcagtg gggacatgac 4741 tttagaccaa gttatacaaa aataagtaat tttataagaa aattatctaa aagacctatt 4801 gtaacagcct ttacagctac agccacagaa gcggttagaa aggatatatt aaatagttta 4861 gaacttcaaa accctaaggt atttgtaaca ggctttgata gagaaaattt aagcttttct 4921 gttataaagg gagaagacaa agaaaaattt atatttgctt atttgggaaa taatataggt 4981 aaggtaggta taatatatac ttctacaaga aaagaagcgg aaagtttata taacaagata 5041 aataaaaaag gttataaagt aggagtatat catgcagggt taaatgatga agaaagaaag 5101 aaaacacaag aagatttttc ttttgataat atagaaataa tagtagccac taatgccttt 5161 ggtatgggaa tagataaatc taatgtaaga tttgttatac atcataacat acctaaaaat 5221 atggaagctt attatcaaga agcaggtcgt gccgggagag atggagaaga aagtgaatgt 5281 atattattat tctcccctaa tgatattcgt cttcaaaaat attttataga tgaaagcttt 5341 ttatctccgg aaagaaaaaa taatgaatat aacaaattaa gagctatggt agattattgc 5401 tacacctcaa aatgtttaag atcttatata ttagaatatt ttggggaaga tgctttagaa 5461 gaaaaatgta ataattgtag tacttgcaat gacaatagag aagaaaagga tataacctta 5521 gaggcacaaa agatattttc ttgtgtttat agaatgaagg aacgttttgg tgtaaatatg 5581 gtggcagatg tacttagagg atcaaaaaat aaaaagcttt tatccttaga tttagatgga 5641 gtatccactt atggtattat ggaggaattt actcaaaagg atatagtagc tttgatgaat 5701 aaactaatag cagatgatta catggtaact acagatgata aatttcccgt tgtaagatta 5761 aggccaaaat cctatgatgt gttaaaagga aaagaaattg tatctataaa ggttagcaaa 5821 atagagaaga aagtaaaagt agataatgaa ctgtttgaga ttttaaaaca gttaagaaaa 5881 gaaatatctc aagaggaatc tgtaccacca tttatgatat tcccagatgc tactttaaaa 5941 gaacttagcg aatacatgcc tacaaaagaa gaagatttat taaaaattaa aggtataggt 6001 gaaagaaaag ctaaggttta tggagaaagg tttatagaag ctattacaga atatatgaat 6061 gaaaagggaa tagatattaa taatatggat aattatgaaa gtactaaaag taataaggag 6121 tctaaaataa agacccatgt attaagctat aacctataca aagaaggaaa aacaataaaa 6181 gaaattgcag aggagcgaaa cctaaaagct ataactatac aggagcattt atttaagtgt 6241 ttgtcagaag gcatggaagt tgatttagat aattttataa aaaaggatta tgagaagctc 6301 atattagata ctataaaaaa agttggggga acaaagctaa agccagtaaa ggatgaatta 6361 ccaccggaag tggattatat gtgtataaag tccgtatggt ataaatataa agatataatt 6421 taaaatatag aataatttta aaccattttt caaaaactag taaaggattc gctaattaat 6481 atttcattat aaagtaatta gtgaataaag ttaaatgaga aaggggtatt ttcatggatg 6541 aactagatat aataaatgaa aaccaattag gtatagccgc tgaaaatgaa aagattaaaa 6601 ctgatttaga aggtcaattt agagctgaaa ctggggaggt tggtttatat atagcaatgg 6661 caagagtagc tcaaagacaa gggttcccag aaatagcaga ggtattaaag gtaattgcta 6721 aagaagaggc agaacatgca gctaggtatg cagaattaaa tgggaaagtt tctgactgta 6781 cgaaagaaaa cctacaaaaa atgctgcagg gcgagatagg atcaaataaa atgaaaaaat 6841 ctttagcagt aaaggctaaa gaagaaaata tagatgaagt acatgatttt atagatgaag 6901 cctctagaga tgaagcaaga catgcaaaga tgttaaaagg attattagat agatattttc 6961 aataaactag gtatatgaaa ataagtgaat aatttataaa tatttactaa aagagggtgt 7021 atcaaaataa atttaatttt gatgcaccct ctaaatttta tacgatgact acccgctcta 7081 atactcccac cttcttcaaa gttaagagta aagagcaggt acgtccctgg ataaccattt 7141 tctaagcttt agtaggagta aaaactcccc ctgaagctta gaaatctgtt tataaaagtt 7201 atattagaga aatctcttta aaagtattcc cttctaaggt ttttattttg aataggttgt 7261 cactaagtat tccataacaa tgaggtgtat tttccttcgg aaatgtaatg gaaccaggat 7321 taattacaaa tatattgttt attttttctg ctaaaggtat atgagtatga ccatatatta 7381 aagcatctcc atcacttata ttaggtatat tgtctttatt aaaaatatgc ccgtgagtta 7441 aaaataatct tttaccatta tataaaatta tagaataatc actcataata ggataattaa 7501 gaaccatttg atctacttca ctttcgcaat tccctcttac agctataatt ttatctttat 7561 agcaatttag aatttctgtt acctttttag gatcatattc tttagggaga ggattcctag 7621 caccatgata aagttcatca cctaaaataa ttagataatc tgctttttct tcttcaaata 7681 tatgtaaagc tttttccaga taataagctg aaccatgaat atcagacata aaaaataact 7741 tcatataaat atctcctttc ctaataacaa agtataaata taattatata ttttttttat 7801 ttttattaaa agtaattatt tcataattta cataataaga aaaaggtatc aattaataat 7861 aaaagagttt agatgtaaaa attattatat agaataagat aaaaacttaa tttattatat 7921 tttttaaata tacgataaag aatattatag cccactcttt gtctgttgaa aaatataata 7981 aagtggttta taattagggt gttatttatt gcattaaaac ctaataaaat ccataaagtt 8041 acaatttatt acaaaaacat ataaataaaa tttaaaaaat atcttataat aaaaagaaaa 8101 taattatatc aatattaaat aaaagtttac tttagtatga ttttaaatta tgctaatatt 8161 ataggtataa agatattaat aagttgctat ttatattgct aaataatttt tgtttgtatt 8221 aaaatattat atttattgca aataaaaagg cgattattgt aacttattat ctaagctata 8281 attattaata tttagtacaa ttttaatcta atattggtat ctttatttta ttaatttgca 8341 atgggagatg cttattaata agtgaggggg aggttataaa aaatgagtag ctcacaaaaa 8401 aatatattag ttattgatga ttctgcaagt attagaagct ttgtaagaaa tatcttagaa 8461 aaagcaaatt acagggttta tgaagcttgt gacggtgaag agggtattga ggtatataaa 8521 aaatgtggaa acattgattt agtaatgaca gatatatata tgcctaaaaa aagtggctta 8581 gaagttgtag tagaattaca aaacaaatat aaaggtacta aaataattgt tttttctgat 8641 gggggaaagg agaattttac taatgattca ggagtatgtg aagctcttgg agcagcttat 8701 tttattagga aggatttaat taaagataag ttactggatt tagtaaatat aatattttca 8761 aaataattat tattaaagtt ataactaaaa ttatagtata ataaggttat tttaagtaac 8821 ctataatata cacctttcat ataatgctgt taaaagcact ataatgaaag gtgtattatt 8881 ttgattgaaa gaaatttgtt taatattatt aataagtatt tacccatggg ctctcaaata 8941 atagttgaag aagataataa caatgaacct ttaataataa aagctaattt caatggatat 9001 ggattaggtg aaataattgt agcttataga tggaaagaag aaaactatat tatggtgcta 9061 gaaaggtact gtaatcagtg gggtgtaata gataatataa gaggaaaagg ctatgatatt 9121 tcttatttaa aagtggcacc tataacagat aatgcaatgg ataatttaat tataggatgg 9181 agaagaggtg ctatatggtc tgagttagat atacttcagt ggacacccta tggttttaaa 9241 agagtaatag atgagggcat atattatagt aaaattgaag tggaaaatat gaaaagtgta 9301 aaagctatga atggtaaaaa tgaaatagcc ttatggttac atgatacagc agaggcttac 9361 aaagtagaaa tatatagatg gagcttagga aaattagtaa aagctgaaga tgtgtatcct 9421 tattatttta agaaagtaat tgatttttat aaaacaaaac tgcaggaaga gccagaccta 9481 ccagtatatt ggtattactt agcagatgcc cagattaaag gtgaaatgta tgaagatgct 9541 ttgaaatcta tagataaagc tttagagctt cctaaagctt atccttctaa gaaagagtta 9601 ataaaattaa gagattatat attatactat aaaaagtgta aaaatataaa tttatatccg 9661 gcaccgatga atactattaa aggagttaga tggggatata taaatgaaaa gggagaattt 9721 ctaattaagc ctttatataa tttagcttta gaatttcagt gtaatggact tgcagttgtg 9781 gaaatagata atctttatgg aattatagat gagaatcaga attatatagt aaagcataag 9841 tatggcttta taagtgattt ctcagaagaa agagctatag ttatcgataa tgaaagattt 9901 aatataatca atgaaaaggg agaagaattg atccctaaaa ttgaaaatta tagttatata 9961 ggaagcttta aagaaggaag agctcaatat ggtgttatag actctaataa gggatatctt 10021 tatggatact tagatagaga aggaagggta atcataccag cacaatatga gtatggaaat 10081 gatttttatg aaggaaaagc tgtggttaga ataaaagaaa atgaatatgc tctaataaat 10141 ataaatggag aaatactaaa taaatatgag tatgcttctg taggaaattt aagagagggt 10201 cttttatctt ttaagaagga tatgggtgaa aaatatggct tcatagatga agatggaaat 10261 gtggttataa agccacaatt cacctatgct caggatttta gtgaaggaag atctgtagta 10321 aatgtttcag ggaatattat gaataactat ggtgtaatag ataaagaagg gaattatata 10381 ataacaccta agtataatga cataattcta ttaggtgaga atagagtggc tgtaggagta 10441 gctatagata aaacatcgcc ttttatagga tccaaatatg ctattgcaga tacagaggga 10501 aacatattaa cagatttcat ttattatgaa gtttcaaatt ataaaaacag aatagcttct 10561 gcttatgatg ataaaaatac attctttata gataaagagg gtaacaaaat tgagaactta 10621 cctatagtag aaggtagtgg aactttaact gtacaaaatg aattaataaa agcctatgtg 10681 gattataaga tttcttattt tgataaagaa ggaaatttaa tatgggaaga aaattcagtt 10741 atttctttaa ataatcagta taaagttata gaagaaaaat acaaacctaa taaggattat 10801 ttagtatatt atccaaaggt tcaaggaatg ggagataagg tcttagaaga tgaggttaat 10861 aataggctca aaattttatc tgaagtggaa cctatagaag aaaatgttga attagaatat 10921 aattatttag gagattttaa aatagagttc tttaacaaaa atttattaga attagagctt 10981 gatggatata agttcccctt tggagcagct cacggcatgc caagtaaaat ctatacaaaa 11041 atagatttaa ctacgggaga attttatgaa ctaaaatact tatttaaaga agatagtgat 11101 tatgtgaaag tgttaagtga tataatagga caacaaataa aaaataaccc agaatactcc 11161 tatatattcc ccgatagtta taatggaata aaagaagatc aaccttttta tgtatcacaa 11221 agtgcattat atatatactt ttatccctat gaaattgcac cctatgctgc agggtttcct 11281 acctttaaaa taccttatga ggatattatg gatataatta atgaatcagg tgaattttgg 11341 atgtcattta attaaaaata agaaaaattt attctagata ggataaaaga gactataaaa 11401 ataaaagact atgaagaaaa atatataata aaataaaagt tttaaagtac tactaagttt 11461 atttcaaatt aaataaaaag aatgaaaagg ctatgaaaaa attaatggga ttcatagcct 11521 attaataatt tataaaatat ataaattatt aatacaaatt tctctaaaat atattaaatt 11581 tctctagata tactatataa tttattacca aaatagtata acttatagat actatgtaag 11641 ttatgtagag gaattttgag taaattgttg aatataacaa tatggaatta aatttaatta 11701 ttaacaattg acataggagg gagaattttg acaaaacaaa taaaacttag aatatatcct 11761 gatggaattg ttcaagcaga agtagaaggt gtaaagggta aaaaatgtac taattatata 11821 agtataattg agaatctttt agaagctaag gtagccgatt cagagtatac acctgaatat 11881 tatgaagaag aagttattga aagctatgaa gaagataata taacactaaa ggaagggata 11941 taatatggct gtaactaaaa aaggggataa gtgggaaata caaaaatcat tatggataat 12001 aagtagtttt gtttttttag taaatggaat gggaatgtat tttgcaggaa aaaaaacaaa 12061 ggtaagaaag tggtataatt atggactaat atatacagca atagcatgga taggcttaat 12121 tatgggagga gaattgacgg gctttctaca aagtgtaggc tctattatat ttcttttgga 12181 ctatataatt tgtattatac attcttttaa aataagaaaa gaatatttaa ttagacgcga 12241 aattttagaa gataaaaatg tagaagagca aaataagata aactttatga gaaataaaat 12301 tgctaaggaa tatgggttag atgatataaa ttcaaataat acaatcaaag ataatacatc 12361 acagaatgat ttagtaagag aaagctctaa tattaatgca gaagctaaaa tagaaaattt 12421 tgatatgaaa aataaagaag aaaatataaa taatatttca ccacgaatgc caaaggtaga 12481 aaatacagta aacaatatta aaaataatgt aaataatgaa gaacttttag atatcaattc 12541 atgtaatgaa ctagagcttt caagactccc aggtatggga ctcatattag ctaaaaaagc 12601 agttaattta agaaatagca gaaatggttt tgattcagta gatgaattta ttgaaatggt 12661 aggtgttaaa ccacattttg tagatacagt aaagactatg atatgttgca acccagttaa 12721 aactgttgaa actgtaaaaa tgtctggaag aagggtagac ttttaatgga aattagaata 12781 catagaattt tacctaaaac tgaagtagaa ggtccgggca cccgatgctg tatatgggta 12841 caggggtgcc ctattcattg taaaggttgc ggtgctaaag aaacctggga cttcaaagga 12901 ggagaacttc tagatactaa tgaggtattt gatattataa aaaattctaa ggaaatagaa 12961 ggagtaacct ttttaggtgg agaacccttt gcccaagctt cagcagtata tgatatagca 13021 ttaagagcta aaagtatagg tttaacagtt ttaactttta cagggtatac ttatgatcat 13081 attttaaaat ctaataaaaa agaatggaat gatcttttat ctgttacaga tttgctcata 13141 gatggccctt tcgatgagga aaaatttgat atttcaaggc cttgggtagg ttcttctaat 13201 caaagttata ggtttttaac accttcttat aagcatctag aaaataactt aacttctata 13261 aaaaataaaa tagaagttag attacataaa gatggagcaa tttttctaaa tggtatgggt 13321 gatttcaata gtataaaaaa taaacttaaa aatttgtagg atggtgaata aaatgagtat 13381 ggaaagtagc aataacacag aaagaacgaa aaaatattta gcaaatatgt ttaaggctcg 13441 attcccttat gtttatataa ctacatggga agaggaaaga gctatatcag ttataaattc 13501 agttgcaaag gacgcttcaa ttataaaaac tcctagaaca acttatatat ggagccaaac 13561 aaatggaatg gctatagaaa atcttaaagg aaaagaggaa actaaacaac cattaaaggc 13621 actggaattt atagaaaaat gtgaagaacc agcagttttt attttaaagg attttcatgt 13681 gttttttgga gtacaaggaa aaaatataga ttatagtcta ataagaaaag ttagagattt 13741 agttacagta ctcaaggcaa gttctaaccc taaaagtgta gtgtttcttt cacctacagt 13801 ggtattgcct aatgaacttc aaaaagatat tactatttta gattttgatt tgccaactat 13861 agatgaaatt aagagtatgc tggatgaaat gatttatgta aatgagcaaa gcggaagaat 13921 tgatatggat cttaatgaat cagaaaagga aaaaatttgt aaggctgcat tgggacttac 13981 tcttcaggaa gcggaaaatg cttttgcaag agctatggtt gaagatggaa agcttaatat 14041 tgacgatatt gaagtagttt tagaagaaaa atgtcaagtg attaagaaga cagggatact 14101 tgaatttata aaaagtgatt taaaaatgga ggatgtagga ggacttgaaa atctaaaaag 14161 atggatttca aagagaaata agtcttggct tgattctgct caaaaatata atctacctgc 14221 acctaaagga gtactaataa caggagtacc aggctgtggt aagagtttaa cagcaaaagc 14281 tataagtgca atgtggcaac ttccactttt aagattagac atgggaaaaa tatttagtgg 14341 tgttgtagga agttctgaag agaatatgag aaaagcaata aaaacagcag aagcagtatc 14401 cccatctata ctttggatag atgaaataga aaaaggattt ggtggggcta gctcctcagg 14461 agatagcgga acttctatga gaatttttgg aacctttctt acatggatgc aagaaaagac 14521 caagcctgta tttgttgttt caacagctaa taatataagt aatcttcctt cagaactttt 14581 aagaaaagga agatttgacg agatattttt tgtagacttg cctacaaaaa atgaaagaga 14641 ggatatattt agactacatt tgaaaaaaag acttacgaat gaagaagttt gtgaagaaat 14701 tagtattaca gaggaactat tatctaatct tgcagatcta acagaaggat ttgtaggggc 14761 ggaaatagag caagctgtaa tagctgcgct ttttgaagcc ttttcagaag atagagcttt 14821 aaaagtaact gatttggaaa gggtaataaa aaatacagtt ccactttcag taacacaaag 14881 agagcaaatt ataaagatta gagaatgggc aaatgtaaga gcagttgccg ctacggcaaa 14941 agaggataga agtgagtatt tagaagtaaa tgaagaaaaa aaggatgaaa aaaagagaga 15001 agatgatata aaaatatcta gaggtggtag aactatagat ttttaaagga ggtataaact 15061 atgtctatat cattagcatt agttcctgca gttttaaccc ttaaagttgt tatgaatgaa 15121 aaagaccttg ataactgggt agaaaattct aaaataaaga tgccaacaac attaataaat 15181 gaggaagaga ttattaaaac tttgaagcag gcaggatata aaataaataa atataaggat 15241 ttgattaaga cagagataag tggagaaaat gaatttatta cttgggaaaa agaaaatgga 15301 atatggaatg ttgtattttc aaaatatgat tccaaagaaa tgatagtcga tttcataatg 15361 aatttaaata gcaaagcagg tagaaaggtt atatataagt caattgaaga gatggaaaat 15421 agaaatgaaa actcaacaac agtggaagaa atattagaac ttcctaaggt agagaaagaa 15481 atctttccta ctaattttcg agataaggac ttgcttttaa aaactcttaa ggattgtgga 15541 gcttgtccta aagaggcatc taacgaagat attcagtgta atactaaaga gtgccaatta 15601 atttttcata aaggagagga tggaagctat aatgtcgaaa ttgaagatac atcttcatta 15661 aaaaatgttt atcatcatct tagtataata gatgaagaat ataaacataa tgtacaagag 15721 tacacctata aaaaagtagt tgaaaaatta aatgaaacag atatgtatat agataatgaa 15781 gaagtacttg aagacaattc tatactttta actgttaata taggagacta aaaagtgcaa 15841 taggagaata tatgacgaag tatataataa attgaatatt atttttataa gaagatatac 15901 acaaaataaa tttgtgtata tttttttgct attgttaaaa taaagtaata cagttatata 15961 agaataatta atgtatatat tttaagaaat tacaaattaa ttaataatac tagaaactgt 16021 caatttcata ggtttatata taaataaaga tgaggtagta ccatattaca aatagtaaaa 16081 tatgaaagtt aagaaaataa cttatttcat taattttaaa aagtaaggag taaaaataaa 16141 aaaaaatttt atatatagca tttttgaaaa cgttataatg aaaggaaaaa gtcgcacttc 16201 aggaaatttt aaccaaagtt aagaaaataa ctattataga aatcttatga aaagtggagt 16261 aaaatgaaaa caataagagg tcgtaccata ttaccgtaag ggggaaacct atatgaatat 16321 gtatctaacg tgtttcattg ctttggtgcc tatagcttgg ttaatggttt cattaggaat 16381 tttaaaaatg ccaggttata aaacttgtcc tgcaacattg gtattaactg caattttagc 16441 agttatagta tggaaaatgc caattttaga tgcagcttct gctgctttag aaggaacggc 16501 attggcttta tggcctataa tacttgtaat cgttgctgca gtatttacct ataatttatc 16561 aattcatact aaaagtatgg atactataaa aaagatgatg acttcaataa ctacagataa 16621 gagaattttg gttttaatac ttgcttgggg atttggcgga tttttggagg ctatagcagg 16681 gtttggtact gcagttgcta ttcctgcaag tataatggca gcacttggat ttgaccctgt 16741 ttttgcggct ataatatgtc ttatagcaaa cactacacct acagcttttg gaggtatagg 16801 aattccagta acaactcttg ctaaggtaac taacatagat gtaattcaac ttagttatgc 16861 agtaggatta cagttatcag ttctaatagt cataattcca atagttttag taatgttaac 16921 aggaaaaagt gtgaaatcta ttaagggtgt ttttggaata gccctagctt caggtctttc 16981 atttgcaata ccagaattat taatggctaa gtatatgggg gcagaattac cagctatatt 17041 agggtcaata acatgtatgg tagtaactat agctatggca aagatatttt acaaagatac 17101 tgcttctaaa aatgtagaaa aaataccttt taaaaaggca gttatagcat ggttaccctt 17161 tatattagtt tttgttttca taattttaac tagtccatta ttcccagtaa taaataaagg 17221 attatctcaa atacaaacaa ctctttacat ttatacaggt gctcatgcta agccatttac 17281 attcttgtgg cttgctacac caggaacatt aattataata gctactttta taggaggatt 17341 aatacaaggg gctaagtttt ctgaaatagt ttcagtatta gtaaaaacta taaagcaaat 17401 gagtaaatct gcaataacaa taatagcgat agtagctatg gcaaagatta tgggatatag 17461 cggaatgata aaatcaatag cagttgtgtt agtagcggtt acgggtagtt actatccttt 17521 aatatcacct ataatcgggg ctttaggaac ttttgtaaca ggcagtgata cttcatctaa 17581 tgtattattt ggaggacttc aagttgaagt agctaagact ttaggattaa atccgtactg 17641 gcttgcagca gctaatactg gtggtgctac tgcgggtaag atgatatcac cacaaagtat 17701 agcagtggct acagcagcta ctggacttgt tggagcagaa ggtaaaatat taaatgcgac 17761 tataaaattt tgtatagttt acgtaattgt tttaggaatc atggcttatt ttatggcacc 17821 tgtatttgga ttctaattgc ttaaactaat gaggaggatg aaacatggca aagataaaaa 17881 taccatatca caagaaaatg attgaaatag ggatagaaga taaaaattta gtagggattt 17941 tagaatcaaa ggcagatgaa tataaaagaa atttaagtca agaagaaatt gttgaggctg 18001 cattggacaa tcctatacaa tgcgaaaaat tagaagattt ggtaaaggga aagaagaaca 18061 tggttataat aaccagtgat catacgagac cagtaccaag taagataaca atgcctatac 18121 ttttaagaag aataagagag gttaatcctg atatagatat aaaaatattg attgctacag 18181 gttttcatag agaatcaaca aaagaagagc ttataaataa atttggcgaa gaaatagtta 18241 aaaatgaaaa catagttatg catgtatcaa ctgatgatag cactttagtg aaagttggaa 18301 aattaccatc tggtggagag cttatattaa ataaattagc aatggaaaca gaacttttaa 18361 tagcagaggg atttatagaa tcacatttct ttgcaggatt ttcaggtgga agaaagagta 18421 tactacctgg aatagcttct gcaaaaacta taatggcaaa tcattgtggt gaatttattg 18481 ctagtcctaa tgctagaact ggaatattaa aagataatcc agtacacaaa gacatgcttt 18541 atgccgctga aaaagccaac ttagctttta tattaaatgt ggtaatagat agtgaaaaga 18601 aagttataaa tgcttttgca ggacatagac aatatgccca tgaaacagga tgtaaatttg 18661 tacttgaact ttcaaaagtt gaaaaggtaa aagcagatat agtggtttca agtaatggag 18721 gatatccatt agatcaaaat atatatcaat cagtaaaagg tatgacagct gctgagtcta 18781 cctgcaagga aggcggagta ataataatgg tagcagcttg taatgatgga catggaggtc 18841 aatcatttta tgataattta gctaatagta aatcaccaag agaactttta gatagaatag 18901 ccaaagttcc tagatgtgaa acagtcccag atcaatggga atttcagata ttagctagga 18961 tgttagataa atttacagta attttggtta cagatatgtg tgatcccaat atgattaaag 19021 ctatgcatat ggagcatgca tataattttg aagaagcttt aaatagagct tataagctaa 19081 agggaaaaga cgctaaagta gcggtaatac ctgatggcgt gtctgtaatt gtaggataa //