LOCUS NC_012623:19 18652 bp DNA linear BCT 06-SEP-2013 DEFINITION Sulfolobus islandicus Y.N.15.51 chromosome, complete genome. ACCESSION NC_012623 SOURCE Sulfolobus islandicus Y.N.15.51 chromosome, complete genome. COMMENT locus start: 1631985; locus end: 1650636 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.547779; n0_4mer:D = 18.610165; n0_4mer:PS = 31.940553 FEATURES Location/Qualifiers source 1..18652 /organism="Sulfolobus islandicus Y.N.15.51 chromosome, complete genome." gene 1..1137 /gene="" /locus_tag="" /db_xref="1631985..1633121" CDS 1..1137 /gene="" /product="radical SAM protein" /translation="MIPISVLVTNAGTVSFHIKGEYNKDRPSKFSDVFRPVVTWNLTR KCNLKCLHCYINASPEGEDGSTTEEALRLIDEMAEMRIPLIIMSGGEPLMRRDFFELA SYARIKGIKLALSTNGTLITESVAKKLKELDFSYVGISLDSYDPEFHDKFRGLNGAFN MTVKGIKNAINVGLNVGLRFTITARNIHQIDEYVKLALELGVKRITFYHLSASGRGKE LREWMYTPEEYVGFINKMIDYAIKLSGKIEIETTLGQFDGVYIAKKLARDEEELEKYM KFVENSGGCGRKMISIYPNGDVYPCQFIDFYKLGNVREKPLKEIIKNIPDLFINTDKY LRGEYCDKCKYKSACKGGDRARAYYWNGDVYGDDPLCPLKTLHI" gene 1110..2162 /gene="" /locus_tag="" /db_xref="1633094..1634146" CDS 1110..2162 /gene="" /product="radical SAM protein" /translation="MPFENAPHLVFWEVTKACPLTCKHCRANAIDKPLPGELNTEESR KLLEDIARFGKVVIVFTGGDPLSRSDIFELMEYAKSLGLVVSIAPSPSHRLDDETMKI ISNYARYMSISLDGATSQTHDWLRGLGSYKYALRGIELGLKYGIQVQVNTLVWKKSYS ELPFVVKLLKEMGVKIWEVFFLIPVGRGTTELDIPRDKYKDVIDFLVEATRYDLIVRT VEAPFFRRAKLEYTPATTNDNELVSTLRELLGEPVKEADKSILPTRDGAGVIFIGYNG DVYPSGFLPLYLGNVKKESLVDIYRKSEVLKKIKDSRFEGKCGICKYNNICGGSRARA FAVYNNPFAEDPMCPY" gene 2295..3704 /gene="" /locus_tag="" /db_xref="1634279..1635688" CDS 2295..3704 /gene="" /product="aldehyde dehydrogenase" /translation="MSQEVIEVRSPSNLNVIGTVKRMHKDEVRGEIEEAYKGFEIISK MPLYKRTAILRKVSEILEREQERLAKLLAMEAGKPIRDSRVEVLRASRLFRHAAEEVG MVLEGKNYRVDAYEYPPGNENRIVVSTREPIGVVTAILPFNFPINSFAHKVAPALAVG NSVVVKPSINTPLAAIEMKKILVEAGLPDSAVRVVTGYSSEIGDEIITHPLVGLITLT GSTQTGLKIASKAVSLGKRIIMELGGSDPIIILEDANIERASSIAVRARFEYAGQNCN AGKRIIVREEIYDKFVKAFNDKARALKVGDPLDETTDVGPVINKESVENLNSVLADAK AKGGKVEILNKGPESGSFFPLTMVTNPSLDMLVLKSEVFGPIVPIVSVKSDEEAIRIA NSTEYGLQSAIFTNDVNRALKLSRELKFGAVIINDSTRLRWDSLAFGGFKKSGIGREG VRETMLEMTENKLIAITLL" gene complement(3984..4958) /gene="" /locus_tag="" /db_xref="1635968..1636942" CDS complement(3984..4958) /gene="" /product="transposase IS4 family protein" /translation="MLNFQGEKVEKVAKTLISACLWNNSVENKSRAYDVSPQTLRNYV VKQGMEVIEKLLERARKISLEILKGVKEIDLSIDWTTKTWYGKPVKGSSEKGNSWNYA TTKYKGKVLLLAFIPQVNGMTKDEIVKVLVEQVMAMGFKIRLITLDAGFYTVDVLNFV SQFKYIVAVPVGDVKVFEEFDGDYTTNSKRHRRDEQIKFRLLVYSKEKVRRKSLVYFA RATNLDLSKREVLDLYNKVRGPIETSYRNIKAFLPFTSSTKFVFRTLIFVLALVLYSL YIIFKGEVGREEFRLLLILLFPDLFNPENFTFNLVDTLIYTIDLFLRR" gene 5157..6159 /gene="" /locus_tag="" /db_xref="1637141..1638143" gene 5488..5664 /gene="" /locus_tag="" /db_xref="1637472..1637648" CDS 5488..5664 /gene="" /product="" /translation="MMISHADVGYAQKGEGDYGDVSPVPLGSKESHDPPIRWLRAKYL HSIMNEHKMIEMKV" gene complement(6183..6617) /gene="" /locus_tag="" /db_xref="1638167..1638601" CDS complement(6183..6617) /gene="" /product="hypothetical protein" /translation="MSWEKSGKEGRLLRWYDVMEAEKYEYTVGPAGEQFFNGLKQGKI VGSKCRKCGRVFVPARSYCEHCFVKIENYVEVNKDEAYVDSYTIIYNDDEGNKLAQPV FIALIRFPNVEGGLLCYAEGNVKVEAKAKITSFEWPLRVKVD" gene complement(6618..7115) /gene="" /locus_tag="" /db_xref="1638602..1639099" CDS complement(6618..7115) /gene="" /product="hypothetical protein" /translation="MVTPLKEEDLSKHYILSYKPNAKYAYTAGQAQSKYLLGLKEGKI YGRKCNKCSRIHVPPKMYCEECFRPTDEWVEVKDEGIVMTAVASFISWTRAKLEEPEI VGIIRLLPSNDRDFVYPGIFHRICASYEQVKSMEIIGKRVKAVWKPKEERKGSIEDIQ CFKVI" gene complement(7127..8305) /gene="" /locus_tag="" /db_xref="1639111..1640289" CDS complement(7127..8305) /gene="" /product="acetyl-CoA acetyltransferase" /translation="MKVNIHLNKRVAVIGAGLTLFRRRLLETPQEIAWEAASKALDEA GLELKDIDCVVIGSAPDAFDGVNLKGEYLSHGSGGIRKPVSRVYVGGATGVMTAIAGW YHVASGLCQKVLAVAEEKMSPDRPHPQAIFRYIWDPILEKPLNPNLIWIFAMEMHRYM ATYGIKKEEIALVSVKNKRNAVNNPYAQLGSKITVEDVLKSEVLVWPVQLLDVSPVSD GGAAIVLASEDLARRYTDTPVWVEGVGWTLDNTEWPARDLSYARYVEFAARMAYKMAG IERPTKEIDVAEPYDPFDYKELHHLEALQLAKRGEAPKLLKEGVFDIDGDIPSSPSGG LLGVGNPIAAAGLMKVISIYWQLKGTAGKMQVKRPVHTGVAQAWGDLMQAGTVIVLRN" gene complement(8302..9447) /gene="" /locus_tag="" /db_xref="1640286..1641431" CDS complement(8302..9447) /gene="" /product="acetyl-CoA acetyltransferase" /translation="LGTFLNRIAIIGIGWFGFRSTTPEVSFREMVFEAASRAYKDAGN INPRNDVDSFISCQEDFWEGISIADEFAPDQMGGAMRPTMTVAGDALQGLAHAVMHIN SGVANVVSIEAHSKVSDILTFSDLVKFAMDPIYVRSINPPNFHFIAGLDAVKFMQRKG ITREDLALVVEKNKKAGLSSPRASYASNISAEDVLKKDYVVYPLSELDMAPFVDGAIV IVVADEEVGKKLKKDDYLVIKGLGFVTDSSNLETAELGKANYMRIASDMAYRMAGIES PRRYFDAVFVDDRYSYKELQHLEGLRVSEEPSKDLREGNLSPQGEIPVNPLGGHIAKG VPLEASGFSLLLDAIDYIKQGKGERALVASWRGIPTLTGSVVVVEKP" gene complement(9511..10626) /gene="" /locus_tag="" /db_xref="1641495..1642610" CDS complement(9511..10626) /gene="" /product="acyl-CoA dehydrogenase" /translation="MSEKELFIESLREFLKRDVEKIATKIDKEDYYPRDLVRKLGELG FLIPLTNGLSHYDMMIILEEIAKVSGSLALIADAQGELAGEMIRLYADERQRKEFLEP MSKGEMIGSFALTEPSGGSDIGSMKTFAEKRNGLWRIKGHKMWITQGLYADIFVTVTR TGSSRHDLSVFIVPRGNCVETRKIEVMGNRGTGTAEVIFHDCEVSKDYVVGEVNNGWN MVNSVLEIGRLAISGIAIGLAEAALEEALKWARSRTAFGNSIYDFQGIRWYFADSVAK LNAVKSMAKDVSNKFDENSKDKGVYVAMLKLLSAIIANEIVDISLQVFGGMGYAKGTT IERIYRDARLLRIGEGTDEVQRHIIAKYIERYGIPYI" gene 10727..12595 /gene="" /locus_tag="" /db_xref="1642711..1644579" CDS 10727..12595 /gene="" /product="AMP-dependent synthetase and ligase" /translation="MSWKIYSLDQIKALAKFSMENPEAFWRDKANYITWFRQPEKILE GEPPYEKWFVGGTTNISYNAIDRHLPDKKDKVAFYWTNERLDSFRSISFQDLYQEVNK AAYVLSELGVKKGDTVSMLMPNIPEAVYFSLATHRLGAILIIHYVGLSEETVAYRFND CGSKVLIVASKTFRNGNEIRIKDFVDKVLESHTTPIQKVLAVPRGYSDFNVNGKRDVV YDDVKPKGKVYVKPVEVEANEPATVYYTSGTTGRPKGLYHSNGGYVIALNWAFKAIFN PTENDVWWTVSELGWPVWPMANLYTIPVMGIPGVLFEGYVGYKRDLFSRVIERYNVSL VWSSTTTLYTLKSLGEESVKSGDTSSLRMILNTGEPLNVGAWMWLNQNLPQVKIADAY WMTEHLSPVGATPYGIGEIPFKAGSAGIQFPGGTYFLIVDDEGKPLPPKQKGYIVLKP LNPALAKMWNDPNYEKIKEKYWSRFPGYFYTGDYGYVDEDGYLFVLGRADDVIRAEGE RIGTLEVESVIVTYPNVAEAAVIGQGGNIIAFVVPRQGVEVGDALRNDIKNYCRNAGY IVDKVVFVKRLPKTKSGKIMRRLLKAILANENPGDVSTLDDIRIMEELKEALKSLS" gene complement(12587..13219) /gene="" /locus_tag="" /db_xref="1644571..1645203" CDS complement(12587..13219) /gene="" /product="bacterio-opsin activator HTH domain-containing protein" /translation="MINLIKHVDIVVSHEDCWTSHMPFTAYTINLEVYPHKNYLRSRI LIDSMENKVISNLMKTHRSVIKVMKVDRFKGGTYVDFLNKYKGSIAGVLYDKEVLILG NLIEGKDEKWSFVTSSKNLREILTEIESLGKVKRVETTDFNPILYPNLTEWEKKVLTV SYSYGYLDYPRRATADELAKLLGISKVTFLYHLRNAQRKLIAFSIKNILA" gene 13351..14829 /gene="" /locus_tag="" /db_xref="1645335..1646813" CDS 13351..14829 /gene="" /product="major facilitator superfamily protein" /translation="MAEKAAVKAGEAIARMDRIPIWGLSYIFIGILGIGFLFTFYDIF DINVSFIQTALTLFHVSNPTSPQIPALLGPIVLLNLVGYIIGALILSPISDVIGRRRM LMITMIITGLGSLYNALANNYVNFLVARTITGIGVGADLAIVNTYIGEVAPINGRARY TSLVFLFSTLGATLGIWLGLFLTTPSAPFPLGLPFALGGSGFFAVNGWRVMYGIGALL ALIGLLLRFSLPESPRWLISKGKLTEAERIVEVMEKKATGKLGNLPPLPNIIQPYIAE RYSYLDALKTIFSSSLYIKRFGILVSMWLFGYMTVYTLAAGLTSVLASLGFAPPEAGM IAAIGVIGFILVPITTFFVGDRLERKTWTVISVVFTIIGGLLIAIAGTNIALSFLGSI ILFYGFNLWVPTSYAWTAESFPTRARSTGFALCDGVGHIGGGIGIIAISSFIGSLIAS GVTTALAIEVFLLIALFQAISTIIAIAIGHRSANKRLDEVSP" gene 14885..15352 /gene="" /locus_tag="" /db_xref="1646869..1647336" CDS 14885..15352 /gene="" /product="flavin reductase domain-containing protein FMN-binding" /translation="MSETIRNIMRLFPLGIVVVTTKWSDNLVGMTVNTFNSLSLNPPL VMFTADKTKGNDVPFIESNGFIVNFVDDEKIFNTFAFKPIKERFKEAKFFEGLDGIPV LADSYAYMEVKKYKTIDIGDHTIVVGEVINGKVVRDNFSPLVYYNRNYWKLCR" gene 15408..16355 /gene="" /locus_tag="" /db_xref="1647392..1648339" CDS 15408..16355 /gene="" /product="3,4-dihydroxyphenylacetate 2,3-dioxygenase" /translation="MINTLRTSHVCIRVSDLDKARYFYSELLGFVETEKDGDYIYLRG IEEGQHHSLILKKANSAGLSYIGFRVSKGEELDKAREELENLGHKVRKFREKGINEAL LFESPEGIPILLYYDMEYVGDLRLAFHRHRGVSPVRLAHVNYMVKDLERELEFFKRFM GYYETERFLDKDGNLAVVWLTRRGDSHEIAIAKSSKNVPGFHHETYYVHDVKDVIKAP DILASVGLWDSIERGPGRHGVTEGYYIYLRDFDKNRIEFFTNDYVVLDPDKWKPIVWT YDQLRYRSDFWGRPIPQSWLTEWVAVEDISTGQLKGWSG" gene 16352..17827 /gene="" /locus_tag="" /db_xref="1648336..1649811" CDS 16352..17827 /gene="" /product="4-hydroxyphenylacetate 3-hydroxylase" /translation="MIRRGTDYIKSIKENPPVVYYEGEVVKDVTEHSAFKIPISTVAK YYDLHWDEKYKEYLRVYNLDVGEETSISFLRPKNKKDLGKLRDGLVKIYDYYRGFFGR SPDYLNLWTMVFYAHAEDYFGKQFGSKFMENAIEIYKEATKRDLFYTHAIVAPMYDRS RPPSQWEDPYIQVGIVEEKPEGVVVRGAAMICTAGPYAEMLWYLPNVRRDSDPRYAIY FSIPTNTKGVKFLSRRGFQPREGGEFEYPISSRFEESDAVLVLDNVLIPWERIIFFKK PELIEDLMWHTVQLRGWFNWHFVIQHYSRLKFLAGLAIAIAEASGTSNFINVQEKIGE ILIYVALNEAALYASVERAQELPNITRPDPYISISASHFNMKTVPRANEILRSISAGS SIPIPAGIKDFENPEERKLLDKYMAMKGLDALERVKMFNLLWDVIGSEAGMRYEQYDR FSRGDPTIRWAQTYTEVFKDRKHEFVKLVKDIIDQMPNPKA" gene 17879..18652 /gene="" /locus_tag="" /db_xref="1649863..1650636" CDS 17879..18652 /gene="" /product="extradiol ring-cleavage dioxygenase class III protein subunit B" /translation="MTIGLFISHGSPTILIDENKWKDLLRRVGKEIEEKYKPETIIVS SPHFVSWTETFYIESSEKLECIQDYYDFPDETYKYCYNALNDTELVEEIVKNAEGKVV KDDKWGLDHGAWIPLFYMFPEYKPKVVTISITDNSPESHYEIGEKIRKAVEKLGRKAV FLATGSPTHRLDLFYFKITPKPTKFDAILMDLIKSGEFEKILKISELYPKEYQTAMPE GNLNTLHMLLGYIKPKKAEILGYDTPWPGVSMLAASFYE" ORIGIN 1 atgattccaa taagcgttct agtaactaat gctggtacag tttcatttca cattaagggt 61 gagtataata aggatagacc tagtaaattc agcgacgtat ttagaccagt ggtaacgtgg 121 aatctcacgc ggaaatgcaa cttgaaatgt cttcattgtt atattaacgc gtcaccagaa 181 ggtgaggatg ggtcaactac agaagaggcg ttaaggctaa tagacgaaat ggctgaaatg 241 agaattccat taattataat gagcggcgga gagccattaa tgagaaggga tttctttgaa 301 ttggcatcat atgctaggat aaagggaata aaattagcct tatctacaaa tggcacattg 361 attaccgaga gtgttgcgaa gaaattaaaa gaactggatt tctcttacgt aggtataagt 421 ttagatagtt acgatccaga atttcacgat aaatttagag gtctaaatgg agcctttaac 481 atgacagtaa agggaattaa aaatgcaata aacgttggac taaacgttgg acttagattt 541 actattacgg ctagaaacat tcatcagata gacgaatacg tgaaattggc cctggaactg 601 ggagttaaga gaataacgtt ttatcattta tcagctagtg ggaggggtaa ggaattaagg 661 gagtggatgt atactccaga agaatatgtt ggtttcataa acaaaatgat tgactatgca 721 attaagctaa gtggaaagat agagatcgag actaccttgg gacaattcga tggagtttac 781 atagctaaaa agttggctag agatgaggaa gaacttgaaa agtacatgaa atttgttgaa 841 aatagtggag gatgtggaag gaagatgata tcaatatatc caaatggtga cgtttatcct 901 tgtcaattca ttgactttta caaattaggt aacgttaggg aaaaaccgct taaggagata 961 attaagaata ttcccgacct attcataaat acggacaagt atttgagggg ggaatattgt 1021 gataaatgta aatataaatc ggcgtgtaaa ggaggagata gagctagagc gtattattgg 1081 aatggagatg tttatggaga tgacccatta tgccctttga aaacgctcca catttagtct 1141 tctgggaagt aactaaagcc tgcccattaa cttgtaaaca ctgtagagct aacgctatag 1201 ataagccgtt gccaggtgag cttaatactg aagagagtag aaaattatta gaagatatag 1261 cgagatttgg aaaggttgtt atagttttca ccggtggtga tccgttaagt agaagtgata 1321 ttttcgaact aatggaatac gctaagtcgc taggattagt agtttcaata gcaccctctc 1381 cttctcaccg tttagacgat gagaccatga agataataag caattatgct agatacatgt 1441 caattagcct agacggagct acttcgcaaa ctcatgactg gttaagggga cttggtagtt 1501 ataaatacgc tttaagagga atagagcttg gattaaaata cgggatacaa gttcaagtca 1561 ataccctagt ttggaagaag agttatagtg aattaccttt cgtagtcaaa ttgctaaaag 1621 agatgggggt aaagatttgg gaagtgttct ttctaattcc agtgggtaga ggaactactg 1681 aattggatat tcctagagat aaatataaag atgttataga ttttctagtt gaagccacta 1741 gatatgattt aattgtgaga actgttgagg cacctttctt taggagagct aaacttgagt 1801 atactccagc tactactaac gataatgagc tggtttctac attacgcgaa ttattaggtg 1861 aaccagtaaa ggaagctgat aagagcattt tgcctactag ggacggggct ggcgttatct 1921 tcataggtta taatggtgat gtctatccta gtggcttctt accattgtat ttaggtaatg 1981 ttaagaagga gagtttagtc gatatttata gaaagtccga ggttttgaaa aaaataaagg 2041 atagtaggtt cgaagggaaa tgtggcatat gcaaatacaa taatatttgt ggggggagta 2101 gggctagggc ttttgcagta tataataacc catttgcaga agacccaatg tgtccatact 2161 aatacgcttt tattttaaat tattttaaac taaagatgaa tgtgcttata aaaatgttat 2221 aagtattata ggtttaaaaa ttggattaag tatttcataa ttacttaaaa acttctaata 2281 caaatacata cttgatgagt caagaggtta ttgaagttcg ttcgccctcc aatcttaatg 2341 taattggaac tgtgaaaaga atgcataaag atgaggttag aggagaaata gaggaggcat 2401 ataagggatt tgaaataata tcaaagatgc ccctctataa aaggacagct atattgagaa 2461 aagtatcgga aattttggaa agagaacaag agagactagc taaactactt gcgatggaag 2521 ccggtaagcc gattagggat tctagggttg aagtattaag ggcttccaga ttgtttagac 2581 atgctgctga agaagtcgga atggttttag aaggtaaaaa ttatagagtg gacgcttatg 2641 agtaccctcc tggaaatgag aatagaatag ttgtaagtac tagggaaccg ataggtgttg 2701 taactgcaat tttacccttc aacttcccca taaactcctt tgcccataag gttgctccag 2761 ctttagcagt aggaaattca gtagtggtta agccaagtat aaatacaccc ctagccgcca 2821 tagaaatgaa gaaaatattg gttgaggctg gattacccga tagtgcagtt agagtagtca 2881 ctggttatag tagtgaaatc ggggatgaga taattactca cccattagtc ggcttaatta 2941 cgttaaccgg ttccacacaa acaggtctta aaatagcctc taaagctgtt tccttaggga 3001 agagaataat aatggagttg ggaggttctg atcccataat catcttagaa gatgccaata 3061 tagagagagc ctcttcaata gctgttagag ctaggtttga gtacgctggt cagaactgta 3121 atgctggcaa gagaattata gttagggagg agatatacga taagttcgta aaggcgttta 3181 acgataaggc tagagcgtta aaggtaggtg accccttgga tgaaactacc gacgttggac 3241 cagtaatcaa caaagagagc gttgagaact taaacagtgt attagcagac gctaaagcta 3301 agggtggaaa ggttgaaatc ctcaataagg gtccagagag tggaagtttc ttcccactaa 3361 ctatggtaac caatccctca ctggatatgc tagtcctaaa gagtgaagtc ttcgggccta 3421 tagtaccaat tgtgagtgtt aagagtgatg aggaggcaat acgaatagct aattcaaccg 3481 agtatggctt acagtctgca atctttacta atgatgtaaa tagggcttta aagttaagta 3541 gagagttgaa gtttggtgct gttatcataa atgatagtac gagattgagg tgggactcac 3601 tagcattcgg cggatttaag aaaagcggta tagggagaga aggagttaga gagacaatgc 3661 ttgaaatgac tgaaaataag ttaatagcaa taacgcttct ttaatatttt tgagtttctc 3721 atcactatag taatttttta ccatcttttg tgaaatatat aaataaggtc tacggaacga 3781 ttttcctata aagcacattc tacatgatta attaaattaa tgaaaattca tgaggcccat 3841 gtggtgttat tattaagaga taagtaaagg gcgaaatgag atttttatat attttgttta 3901 gtaaaaaata gttaaactat aacgttacaa ataaatgggg ttaagggggc ggaaagcctc 3961 gcctctctgc ggtagaccca aaatcacctc cttaaaaata aatctatagt gtaaataagt 4021 gtatctacta gattaaatgt aaaattctct ggattgaata aatcaggaaa taaaagaatt 4081 aataataatc taaactcctc tctccccacc tcccccttga atatgatata taaggagtag 4141 agtacaaggg ccagcacgaa gatcaacgtg cgaaaaacaa acttagtaga actagtaaat 4201 ggaagaaaag ccttaatgtt cctataagag gtctctatgg gacctcttac cttattatac 4261 aaatccaaca cttccctctt ggataggtct aggttagtag ccctagcaaa ataaacaaga 4321 ctctttctcc tcactttttc cttgctgtac acgagaagcc tgaacttgat ctgctcatcc 4381 ctcctatgcc tcttactatt agttgtgtaa tccccgtcaa actcctcaaa caccttaaca 4441 tccccaacag gcacagcaac tatatactta aactgtgaaa cgaagttgag cacatcaact 4501 gtgtagaaac cagcgtcaag agttatcaac cttatcttga atcccattgc cattacttgc 4561 tccacaagaa ccttcactat ctcgtcctta gtcataccgt tcacttgcgg aataaaggca 4621 agtaaaagta ctttcccctt atacttggtt gttgcgtagt tccacgagtt tcctttttca 4681 gagctccctt tcactggttt cccataccac gtcttggttg tccagtctat tgaaagatct 4741 atctccttta ccccctttaa tatctccaag gatattttcc tagctctttc caatagcttt 4801 tcaatcactt ccatcccttg tttcactacg taattcctca aggtctgtgg ggatacgtca 4861 tacgctctgg acttgttctc tacagagttg ttccacaaac acgcggagat gagagttttc 4921 gctaccttct ctaccttttc cccttggaag ttcaacatgg aaagtaattt atatcctatt 4981 tgttgaatgt tcggtgaggg agaccgggtg ttaccatctt cctatctcac gtggtaatac 5041 tccatctccc tcaccttaaa ccctttcttc aattgaattc tttatactct tgtaaatttc 5101 tttatctttt ataaattcga tattatccta ccagaaatat tttttctaat acgattttgg 5161 gtctatcgtt ccagggcggg gagaaattca gaaggagaaa atttggtaat gataaaacta 5221 agaagataaa agaaggtcta agcaacgtat atttatggtt agaattaaca tctaccactc 5281 cagagttata ttatcttttc atggataaac ttagcagaat agtgatggaa aataacgtcg 5341 atttggcatg gaagtaattg gaagaatttg aacattattt attggagctt aataagggta 5401 agactaggga agtagaattg ggctgaattc tttttcacgt taatagagat ctttttatat 5461 ctgtttataa caaaaaatta ttgataaatg atgatctctc acgccgatgt gggctatgcc 5521 caaaagggtg agggggatta cggagatgtg agccccgtgc cgttgggctc gaaggagtcc 5581 catgacccac ctataaggtg gttgagggct aagtacctac actcgatcat gaatgaacat 5641 aaaatgattg aaatgaaagt gtagggacaa acggaggact cttgaaaaaa tcagtgatat 5701 gaaaaaggct ctaattaatt acttggtttc tatacaagga gacagtgacg aagcattttt 5761 aataataagg aatgaagctt ttaatttaat tcttggcagt aatatatacg agttaaaaat 5821 tagtgaacta agcgaaaatg agaggaaatt ctccgagagt tttagacttt atactgcgtt 5881 gaaattgttg ttagacgagg agaataaagt aaaaaataag agacttcttg gagaagtttt 5941 tctataagca agataaagga taaggacgga aaagttgtaa atgttatgat aagcttcgcc 6001 agtgctaagg aaatattgaa tttaagagaa aactcaaata tcgcagttaa acttatgcgt 6061 agagttgaag atgtctgcat atttttatcc ggtagtacgt tatacggaat gattccttgc 6121 aatgttgagt tggatttgaa tacagaatac atatattaag ggttaaaatg ttttcgaaaa 6181 aatcagtcaa ccttgactcg tagaggccat tcaaaactcg taattttagc ctttgcctcc 6241 actttaacat ttccttcagc gtaacacagc aatcctcctt caacatttgg aaatctaatt 6301 agggcaataa acactggttg tgctaatttg ttaccttcat catcattgta gattattgta 6361 tacgaatcca cgtaagcctc atccttattt acttccacgt aattctctat cttgacgaag 6421 cagtgttcac aataggatct agcagggacg aagactcttc cacacttcct acacttactt 6481 cctacaatct taccttgttt cagcccgtta aagaactgtt ctcccgctgg gcctactgta 6541 tactcgtatt tttcagcttc cattacgtca taccatctta atagccttcc ttcttttcca 6601 ctcttctccc aagacattta gatcacctta aagcattgga tatcttcaat acttcctttc 6661 ctttcctcct ttggcttcca caccgcctta accctcttcc ctatgatttc catactcttc 6721 acttgttcat aacttgcaca tattctgtgg aatattccag ggtatacgaa atccctatcg 6781 ttagaaggta atagccttat aatcccgact atctctggct cttccaactt agctctagtc 6841 caacttatga agctagcaac tgcagtcatt actattcctt catctttaac ttcaacccac 6901 tcgtcagtgg gtctaaagca ttcctcacaa tacatttttg gcggtacgtg aattctactg 6961 cacttattgc acttccttcc ataaattttt ccttccttaa gtccaagtag atatttgctc 7021 tgagcctgtc ccgcagtgta tgcgtattta gcgtttggtt tatatgagag tatataatgt 7081 ttgcttaagt cttcttcttt tagaggagtt accatctcat atcacctcaa ttgcgtaaaa 7141 ctataaccgt accggcttgc attaaatctc cccaagcctg ggctacacca gtatgtactg 7201 gtctcttaac ttgcattttc ccagcggtcc cctttaactg ccaatatata cttatgactt 7261 tcattaaacc cgcagcagca ataggattgc ccactcccag taaacctcca ctgggactac 7321 tgggtatatc accatcgatg tcgaatactc cctccttcaa taattttgga gcctctcctc 7381 tcttagccaa ttgtagtgcc tctaaatgat gtagttcttt gtaatcaaac ggatcatatg 7441 gttcagcaac gtctatttcc ttagttggtc tctcaatccc agccatttta taagccattc 7501 tagcagcgaa ttccacatat ctagcgtaag ataagtccct agcaggccac tccgtattgt 7561 ctaacgtcca tccaactcct tcaacccaaa ctggcgtatc agtatacctc ctcgctaagt 7621 cttcagaagc taatacgatt gccgccccac catcactaac tggactaacg tctaagagtt 7681 gaactggcca aactaatact tcgctcttta acacgtcctc tactgttatt tttgaaccta 7741 attgcgcata tggattattt actgcattcc tcttgttctt aacggaaact aacgcgatct 7801 cctccttttt aattccatag gttgccatat atctatgcat ttccattgca aatatccaga 7861 ttagattagg gttcaagggt ttttcaagga ttggatccca tatgtatctg aatattgctt 7921 gaggatgagg tctatctggg ctcatctttt cctcagctac agcaagtact ttttggcata 7981 aaccactggc aacatgatac catcctgcta tggcagtcat aactccagta gcaccaccca 8041 cataaaccct acttactggt tttctaatgc ccccagaacc atgtgataag tattcgccct 8101 ttaggttaac tccatcaaaa gcatctggtg cacttccaat aacaacacag tcgatatcct 8161 ttaactctag tccagcctca tctaatgcct tacttgcagc ctcccatgca atctcttgtg 8221 gagtttctag tagtcttctc ctaaatagag ttaagccagc acctattact gcgactcttt 8281 tatttaaatg aatgtttacc ttcatggctt ttccaccacc acaactgatc cagtaagagt 8341 gggaattcca cgccaagacg cgacaagtgc cctttcacct ttcccttgct taatataatc 8401 tattgcgtct aacagtaatg aaaaacctga agcttctaaa ggaactccct tagctatatg 8461 cccacctaat ggatttaccg gaatttctcc ttgaggagag agatttccct cccttaagtc 8521 ctttgatggt tcctcagaaa ctctcaatcc ctccaagtgc tgtaattctt tgtaactgta 8581 tctatcatca acaaaaacag catcaaaata ccttctaggc gactcaattc cagccattct 8641 atatgccata tctgaggcta tcctcatgta gtttgccttt cctagctctg cagtttctag 8701 gtttgaggaa tcagttacaa atcccagtcc cttgattact agataatcat cttttttcag 8761 ctttttacca acttcctcat cagcaactac tataactatt gctccatcaa caaaaggcgc 8821 catatccaac tcactaagag ggtaaactac gtaatctttc tttaacacgt cttcagctga 8881 tatattacta gcataagacg ctctaggaga tgatagacca gctttcttat tcttttccac 8941 tactaatgct aagtcttccc ttgttatccc ttttctttgc atgaacttta ccgcatctaa 9001 ccctgcaata aaatggaaat ttggtggatt aatggatcta acgtatatgg gatccattgc 9061 gaatttcact aagtcactaa acgttagtat gtcgcttacc ttagaatggg cttcaattga 9121 cactacgtta gctacaccgg aattaatatg cattacagcg tgagctaatc cttgaagcgc 9181 gtctccagct acagtcatgg ttggtctcat tgctcctccc atttggtctg gcgcgaattc 9241 gtcagctatc gatattccct cccagaagtc ctcttggcag gatataaaag agtccacatc 9301 atttctagga tttatatttc ccgcatcctt atatgcccta gacgcagcct cgaaaaccat 9361 ctctctaaat gagacttctg gagttgtaga cctaaagccg aaccaaccta tgcctattat 9421 ggcaattcga ttcaaaaaag tccccaaata tattctcttg acgtacttat taaagctttt 9481 tagccttacc tatgaaagga tcgaaagtaa ctaaatatac ggtattccat accgctcaat 9541 atatttagca ataatgtgtc tttgtacttc atcagttccc tcacctatcc taagtaatct 9601 ggcatcacga tatattcgtt caatagtggt tcccttagcg taacccatac caccaaatac 9661 ttgcaaggag atatcgacta tttcgttagc gataatcgcc gataatagct ttaacattgc 9721 tacgtaaact cccttatcct ttgaattctc atcaaactta ttgctaacat ccttagccat 9781 tgattttacc gcgttgagtt tagctacgga atcggcgaag taccatctta tcccttgaaa 9841 atcataaatt gaattgccaa atgctgttct agatctagcc cacttaagag cttcttccaa 9901 cgcagcctca gccaaaccta ttgcaatccc agatatagca agtctcccta tctctagtac 9961 tgaatttacc atattccacc cattatttac ttctccaact acgtaatctt ttgacacttc 10021 acaatcatga aagattacct cagcagttcc agttccccta ttacccatga cttctatttt 10081 tctagtctca acgcaattac ccctaggcac tatgaaaacg gataaatcat gcctagatga 10141 gccagttctc gtaactgtga cgaaaatatc agcgtaaagt ccttgagtta tccacatctt 10201 atgtcctttt attctccata atccatttct tttctcagcg aaagtcttca tggagcctat 10261 atcacttcca ccagaaggtt cagttagggc aaaactacct atcatctctc ccttactcat 10321 cggttctaga aactccttcc tttgtctttc gtctgcatat aatctaatca tttcgccagc 10381 caattctcct tgagcgtcag caattaacgc taaggacccg ctaaccttgg caatttcttc 10441 taaaattatc atcatatcgt agtgtgaaag tccattagtt aaagggatta gaaagcctaa 10501 ctctccgagt ttcctaacta aatctctagg gtagtaatct tctttgtcta ttttagttgc 10561 tattttttca acatctcttt tgaggaattc cctcagtgat tctataaaaa gctctttttc 10621 gctcatatat ttatcctaca tttaataact tttaaatctt atatcaatct atcattattg 10681 aacgaaaggt atatataatt tttaatttac aaatgtatat gataacatga gttggaaaat 10741 atattctcta gatcagatta aagcattggc gaaattctct atggaaaatc cagaagcctt 10801 ctggcgagat aaggctaatt acataacttg gtttaggcaa ccagagaaaa tacttgaggg 10861 agaaccaccg tacgagaagt ggttcgttgg aggaaccaca aatatatcct ataacgctat 10921 agatagacat ttaccagata agaaagataa ggtggcattt tattggacca atgaaagatt 10981 agatagtttt aggtcaatat cctttcaaga tctttatcaa gaagtaaaca aggcagccta 11041 tgtcttaagt gaattgggcg tgaaaaaagg cgatacggta tccatgctaa tgcctaatat 11101 accagaagct gtatacttct ccttagcaac acacagactg ggggcaattc taataataca 11161 ttatgtaggt ttgagcgagg aaacagtggc atataggttt aatgattgcg gttcaaaagt 11221 attgattgtt gcttcaaaga cgtttaggaa tggaaatgag ataagaatta aggattttgt 11281 ggataaagtt ttggaatctc atactacacc catacagaaa gtcttggcag tgccgagggg 11341 atattcagat tttaatgtta atgggaaaag ggatgttgtg tatgatgatg tgaaacctaa 11401 agggaaagtt tacgttaaac cagtggaagt tgaggctaac gagccagcga cagtttatta 11461 cacgtctgga actacgggaa gacctaaggg attataccat agtaatggag ggtatgtgat 11521 agcactcaat tgggctttta aggcaatatt taacccaaca gagaatgacg tttggtggac 11581 tgtttcagaa ttaggttggc cagtatggcc aatggcaaat ttatacacga taccagtaat 11641 gggaatacct ggtgtgcttt ttgagggata tgttggttat aaaagggatc tattctcgag 11701 agtaattgag agatataatg taagcctagt ttggagttct accacaactc tttacactct 11761 caagagttta ggagaggagt cagttaagag cggagataca tcaagcttaa gaatgattct 11821 taatacagga gaacctttaa acgttggagc gtggatgtgg ttaaatcaga atcttcctca 11881 agttaagata gcagatgcgt actggatgac agagcattta tcgccagttg gtgcaactcc 11941 ttacggaatc ggcgaaattc cctttaaggc aggttccgct ggtatacaat tcccaggagg 12001 aacatatttc ttaattgttg acgatgaggg aaaaccatta cctcctaagc aaaaggggta 12061 tatagtgtta aaaccgctta acccagcctt agctaaaatg tggaatgatc ccaattacga 12121 gaagataaag gagaagtatt ggtctaggtt cccaggatac ttctacactg gagattacgg 12181 ttatgttgat gaggatggat atctgttcgt gctgggaaga gctgatgatg taataagagc 12241 tgaaggggag aggataggaa cacttgaagt tgaaagtgta atagtaactt atcccaacgt 12301 ggccgaagct gccgtaatag gtcaaggcgg taacataata gcgtttgtag tcccaagaca 12361 aggggttgag gttggtgacg cactcagaaa tgacattaag aactattgta ggaacgctgg 12421 ttacatagtt gataaagtag tgtttgtgaa gagactgcct aaaaccaaaa gcgggaagat 12481 aatgagaagg ctactaaagg ctatcctagc taacgagaat ccaggtgatg tatcaacatt 12541 ggacgatata aggataatgg aggaacttaa ggaagcgttg aagagcctaa gctaaaatgt 12601 tttttatgga aaacgcaatt aacttccttt gggcatttct caaatgatag aggaacgtta 12661 ctttacttat tcctaatagc ttagctaatt catcggcagt tgctcttctg ggatagtcta 12721 aataaccata ggaataggat accgtaagca ctttcttttc ccattcagtc agattagggt 12781 agagaattgg gttaaagtca gttgtctcca ctcttttcac ctttcctaaa ctttcgatct 12841 cagtaagaat ctctcgaaga tttttgctgg aagttacaaa tgaccatttt tcgtctttac 12901 cttctatgag attacccaga atcaacactt ccttatcgta gaggacccca gctattgatc 12961 ccttgtattt atttaaaaaa tccacataag ttcctccctt aaacctatct accttcataa 13021 cctttataac gcttctgtgt gttttcatta agtttgatat aaccttattt tccattgaat 13081 cgataagaat cctactcctt aaatagttct tatgtggata aacttctaaa ttaatagtat 13141 atgcggtaaa tggcatgtgt gaagtccaac aatcttcatg gcttacaact atatctacat 13201 gtttaatcaa gttaatcatg tactatttaa actctttaaa aatataaatg ttatgtatta 13261 taagaaacta taatatagta tactgttagt cgtatgttta ttaaactagt ttaatataga 13321 atattaaatt attgatttga aaagccaaat atggcagaaa aggctgcagt aaaagcaggg 13381 gaagcgattg ctagaatgga tagaatccca atatggggac tttcatatat ttttatagga 13441 atattaggta tagggtttct cttcacattt tatgacattt tcgatataaa tgtatcattt 13501 atacaaacgg cattaacgct atttcacgtt agcaatccaa cttctcctca gattccagca 13561 ttactaggcc ccatagtcct attaaaccta gtagggtata taataggagc ccttatactt 13621 tctccaatat ctgacgtaat aggccggagg aggatgctaa tgataactat gatcattaca 13681 ggccttggca gtttatataa cgcattggcg aataattatg ttaatttttt agtagcaagg 13741 accataactg gtattggtgt tggtgctgat ttagcaatag ttaatactta tattggagaa 13801 gtagctccca ttaacggaag ggctagatac actagtctag tattcttatt ttcaacacta 13861 ggcgcaacac taggcatatg gttaggattg ttcttaacaa cgccctctgc tccatttcct 13921 cttggattac cgtttgcact tggtggaagt gggttctttg cggttaatgg atggagagta 13981 atgtacggga taggtgcgtt attggcttta ataggattgc tcttaaggtt tagcttacct 14041 gaatctccaa gatggttaat atctaagggt aaattaactg aagctgaaag gatagttgag 14101 gtgatggaga agaaagctac tggcaagtta ggtaatctcc caccattacc caatataatt 14161 cagccttata ttgcagagag gtattcctat ttagatgcat taaagaccat atttagttcc 14221 tcactttata taaagaggtt tggaatactt gtctcaatgt ggttatttgg ttatatgacc 14281 gtctatacct tggcagctgg tttaacatct gtattagcct cactgggatt tgctccacca 14341 gaagctggaa tgattgcggc aataggtgtt ataggtttca tattagttcc tataacaacc 14401 ttctttgttg gagatagact tgaaagaaag acgtggacag tcatttcagt agtcttcaca 14461 ataattgggg gattattaat agctatagct ggtactaaca tagcattatc tttcctagga 14521 tctataattc tcttttatgg ttttaattta tgggttccaa catcatacgc ttggactgct 14581 gagagttttc cgactagggc taggagtact ggtttcgcct tatgtgacgg tgtaggtcat 14641 atagggggtg ggatagggat tattgcaatt tcctctttca taggttctct gatagcttct 14701 ggggtcacta cagctttggc aatagaggta tttttgctaa tagccttatt ccaagcaatt 14761 tcaacaataa ttgcaatagc aataggacat aggtctgcta ataagagatt ggatgaggtt 14821 tcaccctaag acatcaactc agtttaatga taaacttaaa taattttttt aagtatatac 14881 tctcatgagc gagacgataa ggaatataat gagattattt ccactaggaa tagtagtagt 14941 tacaactaaa tggagtgata atttagtagg aatgacggtc aacacattta attcgctttc 15001 tttaaatcca ccattagtta tgtttaccgc agataaaact aagggtaatg atgtaccttt 15061 tatcgagagt aatggtttta tagtaaattt tgtcgatgac gaaaaaatct tcaatacatt 15121 tgcctttaag cccataaagg agagattcaa ggaggcaaag ttcttcgaag gtttagatgg 15181 aatacccgta ttggctgaca gttacgctta catggaagtt aagaagtata agactattga 15241 tattggtgat cacaccattg tagttggtga ggtaattaat ggaaaggttg ttagagataa 15301 tttctcaccc ttagtctatt acaatagaaa ttattggaag ttatgtagat aaccttaaat 15361 cagtttaata gtgaattaat ttatcttttt gcacttgata gtgtttgatg atcaacactt 15421 tacgtacatc tcatgtgtgt ataagagtta gcgatttgga taaggcgaga tacttctact 15481 cagaactctt aggatttgtg gagacagaaa aggatggcga ttatatttat ttgagaggga 15541 ttgaggaagg tcagcatcat agcttaatac taaaaaaggc caactcggct ggtttatcgt 15601 atataggctt tagggtaagt aaaggagagg aattagataa ggccagagaa gaattggaaa 15661 acctaggtca taaggttagg aaatttaggg aaaagggtat taatgaagct ctattatttg 15721 aatcccccga aggaatccca atacttctat actatgacat ggagtatgta ggcgatttaa 15781 gattagcatt tcataggcat aggggagtga gtccagtcag gttagcccac gtaaattata 15841 tggttaagga cttggagaga gaattggagt tctttaagag attcatgggt tactatgaga 15901 ctgagaggtt cttggataag gatgggaatt tggcagtagt gtggttaact agaagagggg 15961 attcacacga aatagcaata gcgaagtcaa gtaaaaacgt tccgggattt caccatgaga 16021 cgtattacgt tcatgatgta aaagatgtca ttaaagcccc agatattcta gcctcagtgg 16081 gattgtggga tagtatagaa aggggtcccg gtagacatgg tgtaactgag ggttattata 16141 tttatttgag agattttgat aaaaatagaa ttgagttctt caccaacgat tacgtggttc 16201 tggatccgga taagtggaaa ccaatagttt ggacctatga tcaattaagg tatagaagtg 16261 atttttgggg aaggccgatt cctcaatctt ggttaactga atgggttgcc gtggaggata 16321 tttccacggg tcaattaaag gggtggtctg gatgataaga aggggaacag attacataaa 16381 aagtataaag gaaaacccac cagtagttta ctatgaagga gaagtagtaa aggatgttac 16441 agaacattca gcatttaaaa taccgatatc tactgttgcg aaatattatg atctacattg 16501 ggatgagaaa tataaggagt acctaagggt ttataacctt gatgtgggag aggaaactag 16561 cataagtttt ctaagaccta aaaacaagaa agatttaggc aaattaaggg atggcctagt 16621 aaagatatat gattactata ggggattctt cggtagaagt ccagactacc taaacttatg 16681 gacaatggta ttctatgcac acgctgagga ctactttgga aaacagttcg gttcaaagtt 16741 catggaaaat gcgattgaaa tttacaaaga agctacaaag agagatttgt tctataccca 16801 cgcaattgtg gccccaatgt acgatagatc tagaccacct tctcaatggg aagatccata 16861 cattcaagtg ggaatagttg aggaaaaacc agaaggtgta gtagtaagag gagccgcaat 16921 gatatgtacc gccggtcctt atgcggagat gttatggtat ttaccaaatg tcagaagaga 16981 tagtgatcct agatatgcaa tatacttctc tatcccaaca aacactaaag gagttaagtt 17041 cttgtctaga agggggttcc agcctaggga aggaggagaa tttgaatacc caatatcttc 17101 tagatttgag gaatccgatg cagttttagt gttagataac gtcctaattc cttgggaaag 17161 gataatattc ttcaagaagc ctgagttaat cgaagaccta atgtggcata ccgttcagtt 17221 aaggggatgg tttaactggc acttcgtaat tcaacattat agcaggttaa aattccttgc 17281 tggtttagct atcgccattg ctgaagcttc tggcaccagt aatttcatta acgttcaaga 17341 aaagataggt gagatactga tatatgtagc tctaaatgag gcagccctct atgcatcagt 17401 tgaaagagcc caagaattgc ccaatattac tagaccagat ccctatattt ccatttcagc 17461 cagtcacttc aacatgaaga cagttcccag agcaaatgag atattaaggt caattagtgc 17521 aggatcatca atacctatac ctgctggtat taaagatttt gaaaatcccg aggaaagaaa 17581 attattggat aagtacatgg caatgaaagg tcttgatgcc ctagaaagag ttaagatgtt 17641 taacctactg tgggacgtta taggatctga agcagggatg agatatgaac aatatgatag 17701 gttcagtagg ggtgatccca caataagatg ggctcaaact tatactgagg tattcaagga 17761 tagaaagcac gaattcgtca aattggttaa ggatataatc gatcagatgc ctaatcctaa 17821 agcttaagtg aacaaaagtt aacttaattt tttatttata tttttggagt tcttgttaat 17881 gacaattggc ttatttatat ctcatggttc tcctacaata ctgattgatg agaataagtg 17941 gaaggactta ttgagaagag taggaaagga aattgaggag aagtataaac cagaaacaat 18001 aatagtctca agtccccatt tcgtctcatg gacggaaacc ttctatattg aaagcagtga 18061 gaagctagag tgtattcaag attattacga tttcccagat gagacttata aatactgtta 18121 taacgcgtta aatgacactg aactagttga agaaatagtg aaaaacgctg agggaaaagt 18181 agtgaaagat gataaatggg gattagatca cggtgcgtgg attcccctct tctacatgtt 18241 tcccgagtat aaaccaaaag ttgtaacaat atcaattact gacaattcgc cagaatcaca 18301 ctatgaaata ggtgaaaaga ttaggaaagc agtagagaaa cttggaagga aagcagtgtt 18361 tttagccact ggttcaccaa ctcataggtt agacttgttt tactttaaga taactcctaa 18421 acctacaaaa ttcgatgcga tattaatgga tctaataaaa tctggtgaat ttgagaaaat 18481 attaaaaatt agtgaacttt atcctaagga gtatcagact gcaatgccag agggaaatct 18541 aaatactcta cacatgctct tagggtatat taaaccaaag aaggctgaga tactaggata 18601 tgatacacct tggcccggag ttagtatgct agccgcaagc ttttatgagt aa //