LOCUS NC_012622:1 18779 bp DNA linear BCT 04-SEP-2013 DEFINITION Sulfolobus islandicus Y.G.57.14 chromosome, complete genome. ACCESSION NC_012622 SOURCE Sulfolobus islandicus Y.G.57.14 chromosome, complete genome. COMMENT locus start: 327821; locus end: 346599 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.515508; n0_4mer:D = 18.822957; n0_4mer:PS = 18.095992 FEATURES Location/Qualifiers source 1..18779 /organism="Sulfolobus islandicus Y.G.57.14 chromosome, complete genome." gene complement(-637..4) /gene="" /locus_tag="" /db_xref="327183..327824" CDS complement(-637..4) /gene="" /product="dTMP kinase" /translation="MKGLLIAFEGIDGSGKSSHAVLLKDWIEMRRDVYLTEWNSSDWI HDIIKEAKKKNTLTPTTFSLIHATDFSDRYERFILPMLKSGFVVICDRYIYTAYARDV VRNVDFNWVKKLYSFAIKPNFTFYIRVTPEVALERIKKAKRKIKPQEAGIDILGELPL EEGFLKYQGMVVEIYDKIAKEESNFITIDGNRPLKDVQMDIRKILGEYIDNSL" gene complement(1..1257) /gene="" /locus_tag="" /db_xref="327821..329077" CDS complement(1..1257) /gene="" /product="Ppx/GppA phosphatase" /translation="MISAVIDCGYNSFRMVIYQVFRNGTFRMIGSSKSYVRIGEGLKE GDIISEEKVAKAERAFMIFKRILNGVNVNEVKIVATSAFRYASNGNEVRYRLSKIIEN EVRVISGEEEGRYAALGILNTLPISEGVFFELGGGSLEIAEVSSGNIIRVHQLPIGAL KLVNLPEREIRKKVSDELSTTNIKKANFIVGSGGNVRALAKLDLKLSSFPIKSIHGYS LSSKQISKYASLLPSLDIDSRQSLPGISKERALTIHSASVIIDELVKYFTGSYIVVSL FGMREGVLTEGKSLDKMSWLEEISYSNAIDPPPIEIFKEVISEVDSKYSFYVASSALL SLIFKMVGYFNPFRACYRFIKESVLPGFTLNEALLVGLICEAAGGKVKNKQAKLLKED ITKKEILSFGNIVKNSIDKYVAGVRL" gene complement(1258..1743) /gene="" /locus_tag="" /db_xref="329078..329563" CDS complement(1258..1743) /gene="" /product="phosphohistidine phosphatase, SixA" /translation="MITLILVRHGDAEPQVDGKDDKDRRLVKKGVKQMRRVSNFLEEL GFNVDRIISSPYLRAYQSAEVILEELYDNDSEKKVETLDDLTPDKEPSLFLEKLKDFA DNSTILVVGHEPYLSNFVKAISGGNVEIKKGGVVIVDYDLKEGRGVLKTLLSQKVLKL I" gene 2387..2554 /gene="" /locus_tag="" /db_xref="330207..330374" CDS 2387..2554 /gene="" /product="" /translation="VRFKVNINFLVTSAGIEIRGGRRRVVNSLIETPNSSDEIVIAFD EVQELSFASKQ" gene complement(2688..3581) /gene="" /locus_tag="" /db_xref="330508..331401" CDS complement(2688..3581) /gene="" /product="2-ketoisovalerate ferredoxin oxidoreductase subunit beta" /translation="VSSLVTPKRIPKFYRGNAACPGCPIPKELDVLLEVLGNKTVLVV PASCTTIIMGDTSGMPSTVPVIHSAFGAPAAIASGIVRALRTRGDKDVIVTVWAGDGS TGDIGFASLSGAAERNEDILYVCYDNEAYMNTGIQRSSLTPKGAWTTTTPEGKREYKK PLPFIIAEHKVPYVATASIAYIYDYEAKVRKAKQIRGFRYLHLLSPCPPGWRFDSKLT IDTAKLAVETGVWPLFEIENGEFRLTSVSKTLLDKKNRKPVAEYLKLQGRFKQLTEEE IKGIQEEIDEMWQEIKKLVKK" gene complement(3578..4735) /gene="" /locus_tag="" /db_xref="331398..332555" CDS complement(3578..4735) /gene="" /product="pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein" /translation="MQVLKRKTLALVGNHAVAYAVKQSKPQVLAVFPITPQTTMLEKI SEYIASEELNAELIKVESEHSALASIYGAALAGARVFTATSSQGLLYMTEMIYWAGGQ RVPMVAAVATRAIAEPWSIWDDHQDFLSKRDAIWIQMMAENVQEAYDMTIQAFRISED ERVILPVMMGFDGFILTHTMERIEVLEDGEVDNFLPPRQFNLIDFSDPIGVGPIATPE DYIKYRYEAMKAMERAKGVIEEVMNEYERISGRKQNGLVECYKCEDAKYVFVTMGAWS GDCKVAVDRLRDAGVEAGLLKIRVFRPFPKEKIEEYLRSMKGVIVLDRAYSYGSGGIL ANEIKATLYGYRVPVYSVIAGIGGKDVRPRHFQKVIEDLINDNLEEERWLL" gene complement(4739..5008) /gene="" /locus_tag="" /db_xref="332559..332828" CDS complement(4739..5008) /gene="" /product="pyruvate ferredoxin/flavodoxin oxidoreductase subunit delta" /translation="VLIKVPMGVPVARPRIGSAGKTGLWRVEKPVIDYNKCTKCRLCV IYCPENTIDLLENLYPQIDYDYCKGCGVCAQVCPPKAIDMVREVK" gene complement(4998..5546) /gene="" /locus_tag="" /db_xref="332818..333366" CDS complement(4998..5546) /gene="" /product="pyruvate/ketoisovalerate oxidoreductase subunit gamma" /translation="MTLIELALRGRGGQGIVTAGELVTKAMVLEDKYAQSIPFFGGER RGAPVVSFLRLSDKPILLHREVYNPDGVAIFDTSLIQIINVTEGLKENGFLLLNTNTP NRIWKSEYIVDATSIAKELGLVVAGWAVVNTAMIGALVKILGQPSLHSLEEAVKEEFP GKIGELNAEAVEMGYKGVKSVD" gene 5723..5899 /gene="" /locus_tag="" /db_xref="333543..333719" CDS 5723..5899 /gene="" /product="carbon monoxide dehydrogenase, large chain (CutA-1)" /translation="MIQEHLPLITVKESYIDDISPKNVVYLSVVRSPIARGIIKNISK PSLGQISLMGSKFI" gene complement(5965..6816) /gene="" /locus_tag="" /db_xref="333785..334636" CDS complement(5965..6816) /gene="" /product="transposase mutator type" /translation="VLAAKGIPYSEIVMDRVAERISNKLKEYKNRELPHDLLALYIHV KIVKVRISESIMERAIYIAIGVDLEGNKFVLDYEVRDREDLDGWKSFLSGLVSRGVSR VDVIVSDDFSGLDRVVSTLFPSSQHQLCITHMVRNLMRVLPDKEELMIRVRDLKSSRK VEEGRKAILSLSQLVQPFSPARAKRLLDAADKYCSFLNFPREIRHYLYTNNTSESFNS TLARFEEELGGYFPSLRSLEVYLYVSIHESNSRWKFRPMSVIRHYSYHLKQLHASRFQ VSLDEDF" gene complement(6810..7187) /gene="" /locus_tag="" /db_xref="334630..335007" CDS complement(6810..7187) /gene="" /product="" /translation="MTKSKNNPGRGNTIRESNTMKVMEEIREKIRKAIKEGVSLREIE EIILQEAMMEEREAYLEVEDDHKNGTYFRYLGTGDGVLRLRVPRTRKGGFRPKILPEK RTSPDYEDFLQQPIRHDSKSRPC" gene complement(7213..7807) /gene="" /locus_tag="" /db_xref="335033..335627" gene complement(7850..8311) /gene="" /locus_tag="" /db_xref="335670..336131" CDS complement(7850..8311) /gene="" /product="hypothetical protein" /translation="MPNEGIKLIFSLQTNLSFLIRTTEGKLTVLIRNAKNKYKSSTTL IIMLEEWIKQLADALDKFVAGEQLTEDERIMVASLIYATLKHLKDFDECNEKLKEVEE KCNKNLDELEKKLDELQKELDKKEVEVKEKLKTLDNLIKIMEVNPRLLPKN" gene 8247..8717 /gene="" /locus_tag="" /db_xref="336067..336537" CDS 8247..8717 /gene="" /product="hypothetical protein" /translation="VRMRKLKLVCNEKINLMPSFGIMTDIVTEKLKEELRKKLGREIP NVLVEFVNYLPPQVLAYVRANDYTIYVNYEQYMRAKRMGYEYEYLYVILLHEYLHVVG IADEREVRRIDLEMVRDKFGENSTAYKIALNLADPRDIYLNESQRLGGKPNTFM" gene 9354..10709 /gene="" /locus_tag="" /db_xref="337174..338529" CDS 9354..10709 /gene="" /product="FAD linked oxidase domain-containing protein" /translation="MDFTELKDIEQKVEEREDFSGEKVRPLAVFFPKDEDEVVRIVRF AKKNRLPIIPWGQGTSLTGAVSCDKNCILVDLSKMNKILEINDIDWYVRVQPGIKLID LFEELEKKGFMLPPDPASFFLCSVGGAVAESSGGMKGVRHGSFREWVLSLRVVLPNGE VIKVGEPLRKNRAGYDLVHLFVGSEGTLGIVTEIWLRIIPIPKRKMVMIAAMLKDFES AGEVIVGLRKNKILPELSEYVDADVVKALNKHLSANLKETEGGMLLISIEEDSVDDVL KVLEGKAVDIKITEGEEAEKLYSVRSQAAIAVKAESKKVFYAEDIVVPVSKLPEAIRR LREIGEKYNTKFYVISHIGDGNLHPNIIIEDKVAREKAFEEIARMAIELGGSVSGEHG IGVQKAKLMAEQIVKHNGVSVLDLMYQIKKLIDPDDIMNPDKYVELAYKYLTSGDRST I" gene complement(10861..11988) /gene="" /locus_tag="" /db_xref="338681..339808" CDS complement(10861..11988) /gene="" /product="hypothetical protein" /translation="MYNMAVAIFNMIVDGEINVKNVQKFFDNLMIAAETLSKAHTIEP LKSLYEKYRDEVKELEELKGKDDIFYFSYLVHKVFDDYFNNGKLKGLLDEISKIKIDK KELLKKFEENVGEIKEDENLKFPVLWTFKTYDLLSLMKKFNSIQDKEFEAEYMGLKVY VTIKPFEGEIGLYDPFVFFTKNRPRLGIRFGEIAIDPYEVRILQLYESREHFILPIVE KTCGKLTLKTKTALTISDPLKFKNTAYLTRALRYSHWALRTSKLSLSEVINYLPFILN SVNKPKSFIKSVMDLHDRMEEEGVDLDYIKKEIETLGWYGIKLPNKPIRREDRGLNKL KELYDLSTKLEDPIVLLTHLLMTIIYVYKVNGYEYKQLFVR" gene 12512..13246 /gene="" /locus_tag="" /db_xref="340332..341066" CDS 12512..13246 /gene="" /product="Insertion element protein" /translation="MGRKPVFRQDVSCPSCGSHHVVKCGRPLGRQKFLCRDCGKYFLG DASYHHHSRKLREEALRMYANGMSMRAISRVLNVPLGTVFTWIKRYGRKKHEKLVELW GRAKELVKGKVVAKVVDEMWTYLYKNARAFYKWVFTCYVYTKLGVYLIYSVGDRDEST FLEVKKYLPDEGRWVSDDYNLYFWLKDHTVVSPVNPNESFHSSLRDRLIRFKRATKAV NRSIRTMMYSIALVLWERRLIPEFVA" gene 13384..13686 /gene="" /locus_tag="" /db_xref="341204..341506" CDS 13384..13686 /gene="" /product="hypothetical protein" /translation="MGTRWKVPVLTQVMLILMEYINLSPRFYSRETVASALVNYVSGL SSWRAVLSHSTLLYYHRRLSYVRYAVPFGRPKIHLLENKSILLISGSIDLNGKSFR" gene 14263..15342 /gene="" /locus_tag="" /db_xref="342083..343162" CDS 14263..15342 /gene="" /product="thiamine pyrophosphate protein central region" /translation="MIRKAVDLILKSEFPVIICGQGALYSMAWDEVTELAELLGILVG TTITGKGCIPETHPLSIGVVGGRGGANFSNSIVDKSDLVILIGSNTDSANTYNWTIPS RGKTVIHIDISETETGNNYDSINLIGDAKVTLRELIKEIKGSGKIGKKNIILDRSAFE DRLSKERREAVNPLRFIKELWSLSPEEAVLIADPGVSAIYTAAFYKAKKVGRYFIFNY GLGGLGYSIPASVGAYFARPNSLIFSLSGDGSFGFSVGELETIRRVNANVVIIIFNNG SYGWIRAEMKARGKDIVGTDFSSPDYVKIAEGYGLSAYGITNDEEISDTLKRAIKNTP SLVEVIVEPEDKFVPPVMPWSKRFL" gene 15368..15562 /gene="" /locus_tag="" /db_xref="343188..343382" CDS 15368..15562 /gene="" /product="hypothetical protein" /translation="MALLYNTVTTLYASPFLWNIESAQDQVIMNFNPYLNVHVNMSNI KKIYFKEYEILPRKGWSFDI" gene complement(16097..16975) /gene="" /locus_tag="" /db_xref="343917..344795" CDS complement(16097..16975) /gene="" /product="Pirin domain-containing protein" /translation="MIRGIDGVIKGRNTMDGAGVKLYRVFGGPDTVDLTDPFLLLDFF GSNKVEEYINGFPWHPHRGIETVTLLFEGKVEHQDSLGNKGTIYPGQVQWMTAGSGIF HQEMPKPLEGTEIPKYNQDPFLVRGLQLWINLPSYKKMTQPVYRDVKSVPKEKFDFGE VSVLAGEFAGIEGPVKVKSDVDPSYIHVKLNGDMKLKVKEGYTVLAYVVDGSARFAPN SPGIGKGNLVIFTREGDEIKISGNASFIVLSGRPLNEPVAWYGPIVMNTEDQIIEAFD DLRKGTFIRHKEILYE" gene complement(17703..17840) /gene="" /locus_tag="" /db_xref="345523..345660" CDS complement(17703..17840) /gene="" /product="transposase, IS605 OrfB" /translation="LIQYRRLQYWIKWQAKKHGMIVEFVNPKYSSVSCPKCGKKMKDW L" gene 17886..18767 /gene="" /locus_tag="" /db_xref="345706..346587" CDS 17886..18767 /gene="" /product="major facilitator superfamily protein" /translation="MNWKLVVLVIGMSLTFWDIFNVPYIINYARKQFEVSTVIANLPL SAEMIGYAIGGVINGLLSSFKGRKIGLLTSMGLVSLGSLIGFLSQTFSWIIIAEFIIG LGIEGEISVVPTYISETVSAERRGRAVGLVTASGFLTTLIVGPIAVVLGGEWRLLFLA GLLVSLIALITRVWLPESPMWIAKKEMKLSWDFGILMMTIVWFLSYFTGYALFSDPIF TFINSHGFTNPALYFTYILYGDPLGVVIGTLLNDNFERKYSVSLVNILAGLFVPFTFD FLYISVILKKVWLAWRS" ORIGIN 1 tcataatctc acaccagcga cgtacttatc aatactattc ttcactatat ttccaaaact 61 taatatttct tttttggtaa tatcctcctt tagtaactta gcttgtttgt tcttaacttt 121 cccaccagca gcctcacaaa tcaaaccaac tagtaacgct tcatttagag taaaaccagg 181 taaaaccgat tccttgataa atctataaca agccctaaat ggattgaagt atccaaccat 241 cttgaagatt aacgataata gagctgatga tgcgacatag aaagaatatt tgctatcgac 301 ctcacttata acttccttaa agatctcaat aggtggagga tcaatagcat tagaatacga 361 tatttcctcc aaccaactca tcttatctaa actcttacct tcagtcagta ctccctctct 421 cataccgaat agggagacaa ctatataact tccagtgaaa tactttacaa gttcgtcaat 481 aataactgat gccgaatgta tagttaaagc cctttcttta cttattcccg gaagggattg 541 tctactatca atatctagag aaggtaaaag ggaggcgtat ttactaattt gtttagaaga 601 gagcgaataa ccatgtattg acttaattgg aaaagaggat aacttaaggt caagtttagc 661 tagtgctcta acgttacctc cagaaccaac tatgaaattt gcttttttaa tgttcgtagt 721 agagagctca tcggatactt ttttcctaat ttccctttct ggaaggttaa ctagcttcaa 781 cgctccaatt ggcaactgat gtactctaat tatgtttccc gaactaactt cagctatttc 841 caatgatcct ccacctaatt caaagaatac cccttcagaa attgggagcg tgtttaggat 901 acccaaggca gcatatctcc cttcctcttc cccggaaatc actctgactt cattttctat 961 tattttactt agtctatatc taacttcgtt accattggac gcatatcgaa atgcactagt 1021 tgcaactatt ttaacttcat tgacatttac accgtttaat atccttttaa aaatcataaa 1081 agccctctct gccttcgcca ccttttcctc agagataatg tctccttcct ttaatccttc 1141 tcctattcta acatatgatt tagaggaacc aatcatcctg aacgttccat tacgaaaaac 1201 ctggtaaatt accattctaa aggaattgta gccgcaatct ataactgctg agatcatcta 1261 aatcagcttt agaactttct ggctgaggag agttttcaaa actcctctcc cttccttcag 1321 atcataatct acaattacaa ctccaccttt cttaatctca acgttacctc cacttattgc 1381 ctttacgaaa tttgacagat acggttcatg gcctacgacg agaatagttg agttatcagc 1441 gaaatcctta agcttttcaa gaaatagaga gggttcctta tctggagtta agtcatccaa 1501 agtctctact tttttctcgc tatcattatc gtatagttct tctaatataa cttcagcaga 1561 ttgatatgct cttaagtatg ggctggaaat tattcgatct acattaaatc ccaattcctc 1621 caagaaattc gaaactctcc tcatttgctt tactcccttt ttcactagtc ttctatcctt 1681 atcgtcttta ccatcaactt gcggttcagc gtctccgtgc ctcaccaaga ttaaagttat 1741 catgttctat aataacgtct cagaatattt aagcattttt gtatagtaga tattcaaaat 1801 ctcaattctc cttatcatat atggtcatgg cactttctac gttcgagttg ggaaaaatca 1861 aatggattta taggtaaata attctaaatg tttaagttat cataacgatt tagaaagact 1921 gaggattttc ttcaaatgac tggaaatact aataatatgg aaatccttct agactataat 1981 ttaagtggaa gagtaagtcg aataaaacat aagaagtaat catttaggta agagttggag 2041 gtttatgaac aaagctttat tcttctacta aagatattta actgtagtct caccagttac 2101 tgttgtgggt acagttgata ttcgatcttt atctaaagga aactatagaa gagcttatag 2161 gaagggagaa tgaggttaaa tattgtattt cataaattct ctctaaaaat tggataataa 2221 ttagtggtca aagagagatt ggaaaacatc attcatgaaa gtttgttaca aatgagatag 2281 ggaaaaggag aaaaataccc ggtatttacg ttaatttaca aggaataagg agtctaaatt 2341 cacttctatc gattttagtc tcagaaatca acaaagagag aatttcgtaa ggtttaaagt 2401 taacattaac ttccttgtaa cttcggcggg aattgaaatt agaggaggta gaagaagagt 2461 tgtaaatagt ttaatagaaa ctcctaactc ttcagatgag atagttattg cattcgatga 2521 ggtgcaagag ttatcctttg catctaagca gtttttagat attttgggga acgtttacgc 2581 tagttaattt taactttgtc tcaaaagtgg atggcgagta taagattgtt gatccaatat 2641 tgaatgagat tgattcagtt agtgttaaaa gaaaaagaaa aaatatttta cttcttaact 2701 agttttttaa tttcctgcca catctcatcg atttcctctt gtataccctt tatttcctct 2761 tcagtgagct gtttaaatct tccttgcaat tttaaatact ccgctactgg tttcctattc 2821 ttcttgtcaa gtagtgtctt acttacacta gtcaatctaa actcaccatt ttctatttca 2881 aagagtggcc aaactccagt ctcaactgca agtttcgcag tgtcaatagt caatttagag 2941 tcgaaacgcc atccgggcgg acatggggat aataagtgta aatatctaaa tccacgaatt 3001 tgcttagctt tcctcacctt ggcttcataa tcgtatatgt aagcaattga agcagtagct 3061 acatatggta ctttatgttc tgcaattatg aatggtaagg gtttcttata ttccctctta 3121 ccttctggag ttgtcgttgt ccatgcgcct tttggcgtca agcttgaacg ttgaattcca 3181 gtattcatat acgcttcgtt atcataacat acgtaaagga tatcctcatt tctctctgca 3241 gcaccgctta atgatgcaaa tcctatatct ccagtagaac catcaccagc ccatacggtt 3301 actattacat ccttatctcc cctagtcctt aaagctctaa caatgccgga agctatagct 3361 gcgggagcac caaatgcact atgtatcact gggacagttg aaggcattcc acttgtatct 3421 cccattatta ttgtggtaca tgaggctgga acgactagaa cggttttatt tcctaaaacc 3481 tctaggagta catctaactc tttaggtatt gggcaacccg gacaagcagc attacctcta 3541 tagaacttgg gtatcctctt aggtgtaact aaactactca caacaaccac ctctcctctt 3601 ccaaattatc gttgattagg tcttcaatca ccttttggaa gtgacgtggc ctaacgtcct 3661 ttccaccaat acctgctatt acgctgtaaa ctggtactct atagccataa agtgtagctt 3721 ttatctcatt tgctaaaatc cccccagaac catacgaata agctctatcg agaactatta 3781 cacctttcat tgaccttaag tattcctcta ttttctcctt tgggaatggt ctaaatactc 3841 tgattttgag caatccagcc tcaaccccag catcccttag tctatccaca gcaaccttac 3901 agtcaccact ccacgctccc atggtaacga aaacgtattt ggcatcttca catttataac 3961 actcaactaa accgttttgt ttccttccac ttatcctctc gtattcattc attacttcct 4021 caataacccc tttagctctt tccatggcct tcatagcctc atacctatac ttgatgtaat 4081 cctctggagt tgcgattggt ccaacaccaa taggatcaga gaagtcaatt aggttaaatt 4141 gtctaggcgg taaaaagttg tcaacctcac catcctctaa tacctcaatc ctttccattg 4201 tgtgagttaa tatgaagcca tcaaatccca tcatgactgg taagattact ctctcatctt 4261 ctgaaattct aaacgcttgt attgtcatat cgtaagcctc ttgaacgttt tctgccatca 4321 tttgaatcca aattgcatct ctcttactta ggaaatcttg atgatcatcc caaatactcc 4381 aaggctctgc aattgcccta gttgcaactg cagcaaccat agggactctt tgacctccag 4441 cccaatatat catctcagtc atgtatagta gtccttgaga agacgttgca gtgaaaactc 4501 tagcaccagc caatgcagca ccataaattg aagccaacgc agaatgctca ctttccacct 4561 ttattaactc agcatttaat tcctcagaag ctatgtattc ggaaattttc tctagcattg 4621 tagtttgagg agttattggg aacaccgcta aaacttgagg tttagattgc ttaacagcat 4681 aagcaactgc gtgattacca actaaagcta aagttttcct ctttaaaact tgcataattc 4741 acttcacctc cctaaccata tctattgcct taggtgggca aacttgtgca caaacaccac 4801 aacctttaca ataatcataa tcaatttgag gatagaggtt ctctaggaga tcaatagtat 4861 tttctgggca ataaattacg caaagtctac acttagtaca cttattgtaa tcaattactg 4921 gtttctcaac tctccataat ccagtttttc ccgcagatcc tatccttggc ctagctactg 4981 gtactcccat ggggacttta atcaacactt ttcaccccct tgtatcccat ttcaaccgct 5041 tccgcattga gttcccctat ctttcccggg aattcttcct ttacagcctc ttccaacgag 5101 tgtaaggaag gttgccccaa gattttcact aaagctccta tcatcgcggt attaacaaca 5161 gcccatccag ctacgactag ccctaattct ttagcaatac ttgtagcgtc aacaatatac 5221 tcacttttcc aaattctatt aggcgtattt gtatttagta gtaagaaacc gttttctttg 5281 agtccctctg taacgttaat tatttgaatg agtgacgtat caaatattgc aacaccgtct 5341 ggattgtaaa cttctctatg taaaagtatc ggcttatctg acagccttag aaatgatacg 5401 actggagctc ctctcctttc cccaccgaaa aagggtatgg attgggcgta tttatcctct 5461 aaaaccatgg cctttgtaac aagttcccca gcagtaacta tcccttgccc cccccttccc 5521 cttaaagcta attcaataag agtcatttta tcacaataat aatattcgac tcgtaggaaa 5581 aaaagttgtc ctaaaacgaa atataataaa gatatttaac gcggttgaac cagattattt 5641 ttatatacag attaaaatat gatatttctc tactgcgaaa tatgtgacaa gattttatta 5701 gttagtttac gtaataactt ttatgataca agaacattta cctcttataa cggtaaaaga 5761 aagttatatt gatgacatta gtccgaaaaa tgtagtttat cttagtgtgg ttaggtctcc 5821 aatagctagg ggtataataa agaacatatc taaaccgagt ctgggacaaa ttagtctaat 5881 gggttctaaa tttatatagc gtttcaagat ttttaatctg gggctactgg gtatagttgt 5941 gtaagaaaat atgtaagcag aaggttaaaa gtcttcatca agactcacct ggaaccttga 6001 agcgtggagt tgtttgagat gatatgagta atgccttatc accgacatgg gcctgaactt 6061 ccaacgcgaa ttactttcat ggatcgaaac gtagagatag acctccaagg agcgaagaga 6121 gggaaagtaa cctccgagct cctcctcaaa cctagccagg gtcgagttga aactctccga 6181 cgtgttatta gtgtagaggt agtgtctaat ctccctgggg aagttgagaa aggaacaata 6241 cttgtcagca gcgtcaagaa gcctcttggc tcgggctgga gaaaagggtt ggacaagttg 6301 gctgagagac aatatagcct tccttccctc ctccaccttc ctggaggact ttagatccct 6361 aactctaatc attagttcct ccttgtccgg gaggaccctc atgaggttcc taaccatgtg 6421 tgttatacag agctggtgtt gagaggaggg aaagagcgtg gacacgacgc gatcgagtcc 6481 agagaagtca tcgctcacga ttacgtcaac cctgctgact cccctgctta cgagtccgct 6541 caagaaggac ttccaaccgt caaggtcctc cctatcccta acttcgtagt ccaagacgaa 6601 cttattccct tctaagtcaa ctcctatggc aatgtaaatg gctctctcca tgatcgactc 6661 gctgattctg acctttacga tcttcacatg gatgtaaagg gctaggagat cgtgaggtag 6721 ttcgcggttc ttgtattcct tgagtttgtt ggatattctc tcggcaaccc gatccattac 6781 gatctcacta tacggtattc ccttggctgc taacacggcc ttgacttgga gtcatgcctg 6841 ataggctgct ggaggaagtc ctcgtaatct gggctggtcc ttttctctgg aaggatcttg 6901 ggtctgaagc caccctttct ggttctcggt actctgagtc ttaatactcc gtctccggtt 6961 cccagatatc tgaagtaggt cccgttcttg tggtcgtcct caacttccaa gtaggcttct 7021 ctctcttcca tcatggcctc ttgcaagatt atctcctcta tttcccttag gctaactcct 7081 tctttgattg cctttcttat cttttctctt atttcttcca ttaccttcat ggtattactc 7141 tcccttatgg tattacccct tccggggtta tttttacttt ttgtcattat ttttcacctt 7201 ttgttaccac aactataact ggtagcccca gttactgcct aagtcaaaga tgaagaagga 7261 gtacacgaag tccttccctt ccttcatctc ttccccagac ttctcccttt cacttctgta 7321 atgcttggtc actactaggg aatagcttgt cccgtctatg accgcgtcca ccttaaggcc 7381 accaacggtc tttgagagca ggttgtagag aatgacgaag acgtcagggt cggagtatag 7441 tctctctact gtcttgtagc ttatctcctc cttcgttagg ttcagtagtg atgccagttc 7501 tgcggtttcc ctgttggata accctaggta ttccttgatt atcagtatgt acgccttctc 7561 ttgtggggtt aacttgctct tcctcccttg ttcttccttg atcttcacga acttccctgc 7621 ttcatctatg tcctgcctta actcttgacc gaacctcctt aatctagcta acctcttcgc 7681 tctcctcagt gttctccatc ttactgagcc tactttcctt gtacagcttg atcaagtcct 7741 ctattgactc cttgaagtcg tcgaagtcct tctgagttaa cttcttattc atgtgttcat 7801 aatacaaaat aagaggtatc taaagttttt gtcccagagt cgcttaaagt tagtttttag 7861 gtaataatct aggatttact tccattattt ttattaaatt gtccaaagtt ttcaacttct 7921 ctttcacttc cacctctttc ttgtctaatt ccttttgcaa ttcgtctaat ttcttttcta 7981 actcatcgag gtttttgtta catttttctt caacttcttt aagtttctcg ttacactcgt 8041 cgaaatcctt aaggtgtttc agtgttgcat aaatgagaga ggctaccata attctctcat 8101 cttctgttaa ttgctcacca gccacaaact tatctaatgc atcggcaagt tgttttatcc 8161 attcttcaag cattataatc aaagtagtag aggatttata tttatttttt gcattcctta 8221 ttaaaaccgt caatttccct tctgttgtgc gtatgagaaa gcttaaatta gtttgcaatg 8281 agaagattaa tttgatgcct tcgttcggca ttatgacaga tattgtaact gaaaagctta 8341 aggaagaact aaggaagaag ttaggaaggg aaattcccaa cgttttagtt gagtttgtta 8401 attacctccc tcctcaagta ttggcatatg tgagagctaa cgattacaca atatatgtaa 8461 actacgagca gtatatgaga gctaagagaa tgggatatga atacgagtat ttgtacgtta 8521 tactactgca cgaatactta cacgtggttg ggattgccga tgaaagggag gtaagaagga 8581 tagatttaga aatggtgagg gataagtttg gtgaaaatag cacagcgtat aagatagcct 8641 taaatttggc tgatcctaga gatatatatt taaacgagtc tcaaaggttg ggtggaaagc 8701 caaacacctt catgtaaaaa agcatttctt ttattattta atacatttta tttaagtata 8761 gtcacttatc taaattgaga acaaaacgtt tatatagaaa agaaagattt cctcttgtgg 8821 aatagaaagt agaaatttat ggtaatgatt atgacgagaa gcttcctata atatttgctg 8881 acccaacttc ttaatgccaa ctttatttgg ggcgttaaac attgacgtta aaggaagtga 8941 tttcactgca gaggtccctt tatcaacact atttagaaaa gccacagtaa taatatatgg 9001 taaagtattt acatctttaa attctataac ttaagttatc aatattgcgg ggttatggtc 9061 cagctaaggc tgggaaaaat aaaaatccag ttagaaaaag gtaaggtagt catggataaa 9121 gactttaata tttcactttg ttttttaaat gtcaaactga tcaaatctag aataaacgat 9181 tttaggagta aggtaagtga gttaataagg cttgaaagga taaagaggaa aaatttaact 9241 tccccataaa aactttttaa ttttaaggaa taaatttgag cattatataa gggacaaagc 9301 tattcatttg cccataaaaa atccttttat taactcacgt ataattgttt attatggatt 9361 tcaccgaatt gaaagatatc gagcaaaagg tagaggaaag ggaggatttt tccggagaga 9421 aagtaagacc attagccgta ttcttcccca aggatgagga tgaagtcgtt aggatcgtta 9481 gatttgctaa gaaaaataga ttacccataa taccatgggg tcaaggaact agtttaaccg 9541 gagctgtttc gtgcgataaa aactgtatat tagtagacct atctaaaatg aataaaattt 9601 tagagataaa cgatattgat tggtacgtaa gagtccaacc agggattaaa ttaatagacc 9661 tcttcgagga actagagaaa aaaggcttta tgttacctcc agatccagca agcttctttt 9721 tatgctcagt tggtggtgcc gtagctgaat cctctggagg gatgaagggt gtaaggcatg 9781 gttcattcag ggaatgggta ttatctttac gtgttgtttt accaaatggg gaggtaatta 9841 aggtcggaga accattgagg aagaataggg ccggatatga tttggttcat ttattcgttg 9901 gaagtgaggg aactttaggt atcgtaacgg aaatctggtt gaggataata ccaattccaa 9961 agagaaagat ggttatgata gctgcaatgt taaaggattt tgaatccgct ggagaagtta 10021 tagtaggctt gaggaagaat aagatattgc cagagctgtc agagtacgtt gatgctgatg 10081 tagtcaaagc gttaaataaa cacttgagtg caaacctcaa ggaaacagag ggagggatgt 10141 tattaatttc aatagaggaa gatagtgtag atgatgtgtt gaaagtatta gagggaaagg 10201 cagttgatat taagattact gaaggcgaag aggcagagaa attgtattca gtgagatcac 10261 aagctgcaat agcagtgaaa gctgaatcaa aaaaagtatt ttacgctgaa gatatagtag 10321 taccagtttc taaactgcca gaagctataa ggagactcag agaaataggt gagaagtata 10381 atactaaatt ctacgttatc tcgcacatag gtgatggtaa tcttcatcca aacataataa 10441 ttgaggataa ggtagcaaga gaaaaggcat ttgaggaaat agctagaatg gcgattgagc 10501 ttgggggttc tgttagtggt gaacatggta ttggtgtgca gaaggctaag ttaatggctg 10561 aacaaatagt taaacataat ggtgtcagtg tattggattt aatgtatcag ataaagaagt 10621 taattgatcc agatgatata atgaaccctg acaagtatgt cgaattggca tataagtatt 10681 taacttctgg ggatagaagt actatttaat ccttacccaa aaactgaaag gagagatttc 10741 ttcgataggg aaaacgaaat agagaaattt aaagagttaa ggacaccatt aatgttagta 10801 ttagggctta gaaggacaga taagtcttct ctaataaaga tagccttgaa tcagttgaaa 10861 ttaccttaca aataattgtt tatactcata accattgact ttgtagacat atattatagt 10921 cataaggaga tgtgttaata gtactatagg atcttccaat tttgtagaca agtcatagag 10981 ttcttttagc ttattgagac ctctgtcctc tcttctgata ggtttattag gtaactttat 11041 tccataccaa cctaaagttt cgatttcttt cttaatatag tccaaatcta ccccttcttc 11101 ctccattcta tcatgtaaat ccattacact cttaataaag ctttttggct tattgactga 11161 attaaggatg aatggcaaat agttaataac ctcacttagc gataactttg aagtccttaa 11221 tgcccagtgg gagtatctta atgctctagt taaatacgct gtgtttttaa actttagggg 11281 atcgctgatc gttaatgcgg tttttgtctt taaggttaat ttaccgcaag ttttctccac 11341 aataggtaat ataaagtgtt ctctgctttc atatagctgt agtatcctaa cctcgtaggg 11401 atctatagca atttcaccga accttattcc tagtctgggt cgattcttgg taaagaaaac 11461 gaaaggatca tagagaccta tctcaccttc aaagggttta atagttacat aaacctttag 11521 tcccatatat tcagcctcaa attctttatc ttgaattgaa ttgaacttct tcattagact 11581 aagtaaatcg tatgtcttaa aggtccaaag tactgggaat tttaaattct catcttcttt 11641 aatctctccg acgttttctt caaacttttt taacagctct tttttatcga ttttgatctt 11701 actgatctcg tcgagtaaac cctttagttt gccgttatta aaatagtcat caaatacctt 11761 gtgtactagg taggaaaaat agaaaatatc gtctttacct tttaactcct ctagttcctt 11821 tacttcatct cggtatttct catatagaga ttttaagggt tcgatagtat gtgccttaga 11881 aagcgtttct gctgctatca ttagattatc gaaaaatttt tgaacgttct taacgtttat 11941 ttctccgtca acaatcatgt taaaaatagc tactgccata ttatacattc aattttgtaa 12001 tattttatac tttattacat cgtaaagtgt actgagactt ctacagactg tttgtagcct 12061 tccacaagag atgttgttct acttgagcaa aactgaaaaa ttattataat tataatattt 12121 tattttttca ttgtgaacta tattcaatta tgaagaatga tataatatat attaatatga 12181 taaatatcta agccatctta tacgtaaatt atatattatt ataataaata aatacttata 12241 taagttaaat taataaacac tatatttatt tttatttttc cgcattataa atgactttta 12301 aatctccgaa aatttggaga gaatatagat atacgctatg tactatattg agagaaagtc 12361 attgtatcat gggacatctt tatttactat aaattttgaa taaaatcata tcaaagtagg 12421 atttgcagct tattaatgaa actctcatta atgggagtgt ggaggtagtg tcgtcgttaa 12481 gttatttata tttgtataac gagtattact tatgggtagg aagcctgtat ttaggcaaga 12541 cgtttcttgt ccctcttgtg gtagtcatca tgttgttaag tgtggtaggc ctttgggtag 12601 gcagaagttt ttgtgtaggg attgtggtaa gtacttcttg ggtgatgcta gttatcatca 12661 tcattctagg aagttgaggg aggaggcttt gagaatgtat gctaatggta tgagtatgag 12721 ggctatttct agggtgctta acgtacctct tggtactgtt ttcacttgga ttaagcgtta 12781 tggtaggaaa aagcatgaga agttggttga gttgtggggt agggctaagg agctggtcaa 12841 gggtaaggtt gttgctaagg ttgttgatga gatgtggact tacttgtaca agaatgctag 12901 ggctttttac aagtgggttt tcacttgtta cgtgtacacg aagctgggag tttacctcat 12961 ttactctgtg ggggataggg atgagagtac tttccttgag gtcaaaaagt atttgcctga 13021 cgagggtaga tgggtgagcg atgattataa cttgtacttc tggttgaaag accacacggt 13081 tgtctcgcca gttaacccga acgagtcctt tcattcctca ttaagggata ggctaattag 13141 attcaagaga gcaacgaagg cagtaaatag gagcattcgc accatgatgt actccatagc 13201 cctagtctta tgggagagaa ggttaatccc agaatttgta gcttaacgac gacactatcg 13261 agtgtggaca acaattttgt taatctaaaa tgaattattt gaattgtttg cgctttatta 13321 atagaacgtt gatgataata cctttttagg gtgagcacgg gaggtattac ttagggtgag 13381 attatgggaa ctaggtggaa ggttcccgtg ctcacccaag tgatgctaat attaatggag 13441 tatattaacc ttagcccgag gttttactct agggagaccg tagcctctgc cttggttaac 13501 tacgtttctg ggttatcctc ctggagggcc gtgttatccc actctactct gctttactat 13561 cataggaggt tgagttacgt gaggtacgct gtgccattcg gtagacccaa aatccacctc 13621 cttgaaaata aatctatatt attaataagc ggttctattg atttaaatgg aaaatctttt 13681 agatagaata aatcatcaga aaacaagagt attaggagta tcctgaactg ctctctcctc 13741 acctccccct tgacggtaga cccaaaatct aattagtaaa aataattttt attcattatt 13801 agtagttcgt aacgatttaa tgtaattagt tagataatta tatgataatt tttataaatt 13861 tccaagttcc atattagatt ttttatattt ccacacaatt aactgaggaa tattattata 13921 atattagaaa atgataaaga tgtatatgat agaatctgtt ttatttacat tgattattta 13981 atacattatt cttaatgctc ttgattatga gtataataaa atatattctt ttatttatta 14041 agaaaaaata tgaggtttaa tgttgaattt atatttgtaa tatgattttg ggtctaccgt 14101 ataaggagag cattcagatt aagtactagt ggaaaacctg gaccagttca cattagaata 14161 cccctagatg ttttagaaga tgaattagaa ggcaacgttg aacttaaagc ccaaaaggag 14221 ttctcgaaat atccatctca aagaccttta gcggatcgtg aaatgataag gaaagccgta 14281 gatttaattt tgaagagtga atttccagta ataatttgcg gtcaaggagc actttactca 14341 atggcgtggg atgaggtaac tgaattagct gagttattag gaattcttgt ggggactaca 14401 ataactggta agggttgtat tccagaaacc catcccttgt caataggtgt ggttggcggt 14461 aggggcggtg caaatttttc gaacagtatc gtagataaat cagaccttgt aattctcata 14521 ggaagtaata cggattcagc aaatacttat aactggacta taccatccag aggcaaaacc 14581 gtaattcata ttgacattag cgagactgag actgggaata attacgatag tataaacctc 14641 ataggggatg ctaaagtaac attgagggag ttgattaagg aaattaaagg tagtggaaaa 14701 attggtaaaa agaacattat tttagataga agtgcattcg aagataggct tagtaaggag 14761 aggagagaag cagtaaaccc gttacgtttc ataaaggaac tttggagtct atcacctgaa 14821 gaggctgtat taatagctga tcccggagtt agcgcaatct acactgctgc tttctacaag 14881 gccaaaaaag ttggtaggta tttcattttt aactatggtc taggtggtct tggctattca 14941 attccagcat ctgtaggtgc ttattttgca aggcctaact ctttgatttt ctctctttct 15001 ggagatggga gtttcggttt ctcagttggt gaactagaga ccataaggag agtcaatgct 15061 aatgtggtta ttataatctt taataatgga agttacggtt ggataagggc tgaaatgaaa 15121 gctaggggta aggacattgt tggaactgat ttttcaagtc cagattacgt taagatcgct 15181 gaagggtatg gactatccgc gtatgggata accaatgatg aagagatatc tgatacgtta 15241 aagagggcta taaagaatac tccttcttta gttgaggtta ttgttgagcc agaggataag 15301 ttcgtccctc cagttatgcc ttggagtaag agatttcttt aaactaaata aaacaaacac 15361 taatggcatg gcattgctgt ataatactgt gacgacatta tatgcttcgc catttttatg 15421 gaatattgaa tctgctcaag accaagtaat aatgaatttt aatccctatc tcaacgtcca 15481 tgtgaacatg tctaacataa agaagatata ttttaaagaa tatgagatct tacctagaaa 15541 aggctggagt tttgatatat aattacatac tatttagatg cgatacaagt tagaatagag 15601 ttttaatgat gctaatggtg tcgctaatct aggatataat ttatactcat ggtatataac 15661 ctaatctcaa ggacggactc aatatagcat acttgatata tgctcctaaa atgtttctag 15721 cttaaacaaa agtcctcaaa aagtaaatca tgtatagtga gatttggaac tataaactaa 15781 cttatttcca tcattattaa gattgaatag tacacgttat tatatgtgaa attcctatat 15841 tgtctactct tcctttatga acttcaagat ttagttcaac tcctataact ttctgcatat 15901 tctttaactt ttacattata ctttttttaa gagaccttgt atttcaagat cactaaaact 15961 ttaatcccat cattacgaat atcaaatcaa cttttttaat cttataatat caattatatc 16021 ccctaaattt tgagagaata tcctgtaatt gattctaaaa aatcataaaa agtaatatta 16081 agtattacgc atgatattat tcatatagta tctctttatg tcttatgaat gtaccttttc 16141 tcaaatcgtc aaacgcttca attatttgat cttcagtatt cataactatt ggtccatacc 16201 aagctactgg ctcatttaga ggtcttccgg ataatactat aaagctcgca tttccactaa 16261 ttttaatctc atccccctcc ctagtgaaga ttactaaatt tccctttcct atacctggag 16321 aattgggtgc aaatctggca ctaccatcaa ccacataggc taatacagta tatccttctt 16381 ttacctttaa cttcatgtcc ccgttcaatt ttacgtgaat gtatgacgga tcaacatcac 16441 tcttcacctt aactggtccc tcaattccag cgaactctcc cgcgaggact gatacttctc 16501 cgaagtcgaa cttctcttta ggaacacttt ttacatccct atatactggc tgtgtcatct 16561 ttttgtaaga tggtaggttt atccataact gtaatcctct tactaggaat ggatcttgat 16621 tatacttggg aatctctgta ccctctaatg gttttggcat ttcttggtga aatattccac 16681 ttccagcagt catccattgg acctggccag gatatattgt tcccttatta cctaaactat 16741 cttggtgttc cacttttccc tcaaataata gcgttacagt ctcaattccc ctatgcgggt 16801 gccaaggaaa tccattaatg tactcctcaa ccttatttga gccgaagaag tccagtaata 16861 ggaaaggatc tgttaaatcc acagtatctg gtccgccaaa cactctgtaa agtttaaccc 16921 cagcgccatc catggtattt cttcctttaa ttacaccatc tattccccta atcataaatt 16981 aatttttgaa ctaactaata aaaacctaat tcaccttagt tatgattatt ttattaagag 17041 aaaaatgatc agataccctc ttccagcaag gcatacctaa tgattggatc ggaaattcta 17101 tactcattat ttcttttctc tatgattcca ttgttatcaa tttcttaaga tctctagaaa 17161 ctgtagtatt gctgactttt attcggtttt ggcaattatc tgactttctt atataaaaca 17221 tattagtcag atctgtatta cacagatctg actggggtgt aggccgtttc gcctcttggg 17281 cttaaagccc gtcggtgagc ttggcctcct ccaattcgaa ccggaagttg ggcttaaagc 17341 ccgaataaaa cataatggtg agtataaatg gagcccccaa ttgcagggat agatgtatca 17401 aaagataaat taactgtact ataataagca gtttaacgtt gagtaaagca ggtttcatca 17461 cttgcgtaag tagtgtagac tgcgctcggt ttttgatgga aaggttttta taccggaagc 17521 tcaccgccct gaaagggcga tggttcccct tccagaggga tcatcgttcc caccatcgat 17581 tagcgtttac atctctcatc tggtgggcag acgagagggt cagagacccc ctcctattta 17641 aattaaccat tgcaataaca tccttgtcat tcttataacc acattttgta cagaggaaat 17701 acctataacc aatccttcat cttcttacca cacttaggac atgaaacaga agagtactta 17761 ggattaacaa actcaacaat catgccgtgc tttttagctt gccatttaat ccaatactgc 17821 aaacgacggt attgtatcaa gtatagtttg taagttttat aaactttaaa ctttcagaaa 17881 aaagtatgaa ctggaaatta gtagtcttgg taatcgggat gtcgttaacc ttttgggata 17941 tattcaacgt tccttacatt ataaattacg ctagaaagca gtttgaagtc tctacagtta 18001 tcgctaactt accattatct gctgaaatga ttggatatgc aattggtgga gtaataaacg 18061 gattgctatc atcattcaag ggaagaaaaa ttgggctatt gacttccatg ggacttgtat 18121 cattaggatc cctaatcggc tttttatcgc aaacgttttc atggataatc atagcagaat 18181 tcattatagg attaggaata gaaggagaaa tcagtgtagt gccaacttat atatcagaaa 18241 ccgtatctgc tgaaaggaga ggtagggcag ttgggttagt tacagcctct ggctttttaa 18301 caacgttgat tgtgggacct attgcagtag tcttaggagg cgaatggaga ttacttttct 18361 tggccggact tctagtttct ctgattgcgt taattactag ggtttggctg cctgaatctc 18421 caatgtggat tgccaaaaag gagatgaagt taagctggga tttcggaatc ctcatgatga 18481 ctatcgtttg gttcttaagc tattttacgg gttatgcgtt attttctgat cccatcttta 18541 cctttattaa ctctcacggt tttactaatc ctgcgttgta cttcacttat attctatatg 18601 gtgatccact gggtgttgta attggtacgt tattgaacga taactttgaa cgcaagtata 18661 gcgtatcatt agtaaacatt ctagctggtc tgtttgttcc ttttactttt gattttctat 18721 atataagtgt tatccttaaa aaggtatggt tagcttggag atcgtaagcc aagattcaa //