LOCUS NC_012563:13 18462 bp DNA linear BCT 26-AUG-2011 DEFINITION Clostridium botulinum A2 str. Kyoto, complete genome. ACCESSION NC_012563 SOURCE Clostridium botulinum A2 str. Kyoto, complete genome. COMMENT locus start: 2384500; locus end: 2402961 FEATURES Location/Qualifiers source 1..18462 /organism="Clostridium botulinum A2 str. Kyoto, complete genome." gene complement(227..3004) /gene="" /locus_tag="" /db_xref="2384727..2387504" CDS complement(227..3004) /gene="" /locus_tag="" /product="viral enhancin protein" /translation="MKGFMKFLMLQALFICAIFGTATNVYADEVKQKELYTLENPTWF KKTGFSKGLGHDKQDLGIILPANVQLTIRQVNPNFKGNLTVRLLNDNNQHETSRTFNQ TSITISTPYSSVPFVDTVYGGSEKPKIEYRVTSSMQTLPIYKKGQNEQSFFNEWDKAA APFALVKDDYFQLLVPQKDKAYMKNMKDFSSIDQLILYYREIFEYYNKLAGISFNTNV QTDKNVPNKYFIKADKSGPGGGYYGGNHTAETSDSVASFWLTKGWGALHEIGHGYQDD FTRGEVWNNIYAHSLQKKDSDVDIFKNGWLYDYGKKDAVDYNVNKLWHQDKAAFNTWG LREQLYGYVLMKDKAGDDSFTHFNQEYRKLANTSGFNTSDYKQFDLISKCYGEISKLD FTPVIESFGGTMTDWQKEENRYKNYKPVAPLNEVVPVSQVSQIQQSLKLETPLSLVTT EDLAATDLTGDVTLNFKIDDFNQIKNQTLYIMNGEKEVKKVVITNPTLSLGQLPVGIY TIYSTNSSNKLYTLDNHYLKVKEANNNITLNYKLRTKSTLVNQEIDFLGISDNLFATA TVDLQNEKLNVKVLNKTPHDYFPNEQYAKIEILDQNNNVTYTKVITGTNAALENSSQT LKKGYKIRLYHREPSRLKIRDNKTVLTNNQTNTLIVTSQGLKNENLNQNLNQELAGRI DSFAAKINAENLMAKSDCAESKIELKLAIDALTEPLRSEMLTKYKDLLPNSTINKENP YLGKKFNATFKGLGDWIFAELNLDLTSKQAKIDIKKGEPHVYFSDTYASILIRSAEGN TVYTKDFIGDKENETLIKNIDIKPGYYITIKHQEPDNRLLITNTENELELEKGNSITY KITDTGLVKSSEDEINKSPENEWNPNKSYNAGDKVSYKEKTYKAKWWSQGFAPDTKVQ NPWETPWELIS" gene complement(3446..5317) /gene="cadA" /locus_tag="cadA" /db_xref="2387946..2389817" CDS complement(3446..5317) /gene="cadA" /locus_tag="cadA" /product="cadmium-exporting ATPase" /translation="LNNVKSIFTDETKRNIFFLVLSGIALIVSFFDVGHLPVNVAWIS IVLCGAPIIIGAIKGLITEFDIKADVLVSMALIASVIIGEIFAAGEVVFIMQIGALLE ELTVAKAQAGIEKLVHLTPRTARIIRGGKEEIIDAKKVQVGDILRVLAGETIAVDGII TKGQTSIDQSVMTGESMPVDKSLGDEVSSGTVNQFGTFEMKAIKVGEDSSLQRMIRLV QSADAGKSKIVGIADRWATWIVVIAVTAAILTWIITGEIIRAVTILVVFCPCALVLAT PTAIMAAIGNATKYGILVREGDALERLSKVKKIVFDKTGTLTYGKPEIVTVKSFSDNY TDEDLYEVLASAELRSEHPLGKAVVECFRQTGNISTEPEKFTMLPGRGVLAKVNGKKI FAGNEKLMKDNHISLKDEVLKEAESYLSKGCTIIYIAIDNIMVGFSVLSDTLRKNAPY MIRNIKALGITPVLLTGDHAEAARYISNKISISEVKADCLPEDKLDTIHNIQIGREMV CMVGDGVNDAPALKKAYVGIAMGGVGSDIAVDAADIALVSDDISQLPHLFELSKKMMT TIKINLSFSMILNFAAIILAITGVLNPIVGALVHNAGSVLVIINSALLLKWKKKSIK" gene complement(5499..5774) /gene="" /locus_tag="" /db_xref="2389999..2390274" CDS complement(5499..5774) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKKCMDSENLHRRLKKIIGQINAIDRMIDEDVPCEDILMQINAA KSALHKSGQVVLEGHLQHCVREGIEHGDADRTIKSFAKAVERFSNMS" gene complement(5897..6187) /gene="" /locus_tag="" /db_xref="2390397..2390687" CDS complement(5897..6187) /gene="" /locus_tag="" /product="bacterial microcompartments family protein" /translation="MKYDALGMIETKGLVGSIEAADAMVKAANVYLIGKEYVGGGLVT VMVRGDVGAVKAATDAGAAAAQRVGELVSVHVIPRPHSEVEVILPSSKEVAK" gene complement(6261..6911) /gene="" /locus_tag="" /db_xref="2390761..2391411" CDS complement(6261..6911) /gene="" /locus_tag="" /product="propanediol utilization protein PduL homolog" /translation="MDNCEEVLKLLLEAVKGKELNNAVNRNSSEIPVGISNRHIHLSQ KDLDSLFGENYGLTKIKDLSQPGQYACKEVVTICGPKGAIEKIRILGPVRSKTQVEVL AGDCIKLGAVSHVKLSGDLNRTSPITIVGPKGSVQLEEGLIVAQRHIHMTPEDAQNLG VHDGEIVSIKFEDLRGGIYNNVAVRANDASSLECHLDIEEANAMGINSKSKVTIVK" gene complement(6911..8509) /gene="eutE" /locus_tag="eutE" /db_xref="2391411..2393009" CDS complement(6911..8509) /gene="eutE" /locus_tag="eutE" /product="acetaldehyde dehydrogenase (acetylating)" /translation="MENFDKDLRSIQQARDLARLGKVAADKIADYTEEQIDKILRNMV RVAEENAVCLAQMAVEETGFGKVEDKTFKNHLAATILYNSIKDMKTIGVINEDKENKL IELAEPVGLVMGIVPSTNPTSTAIFKAMISIKSRNAIVFAPHPAAAKCTIKAVELMRD AAIEAGAPENIISAVTIPTIGATNELMKSKEVAIIIATGGPGMVKAAYSSGTPAIGVG AGNSPAYIERTADVEKAVKNIIASKTFDNGTICASEQSIICEECNHDLVVAEFKKQGG YFMTEEETEKVCKLLFKKGNAMNAKFVGRSPQVIASAAGFTIPAGTKVLIGRQNGVGE GYPLSFEKLTTVLGFYTVKDWHEACELSIKLLQNGIGHTMSIHTEDRDMVMKFARKPA SRILVNTGGTQGGTGASTGLNPSFTLGCGTWGGSSVSENVTPKHLMNIKRVAYGIKDC TNLASNDPTFNCIKTAENCHGVQNQFMNMSPAQIAAAAEVLNKANNCAENTNTCTECS NENTKNEELLDLVNQIVAAMKGAN" gene complement(8544..9341) /gene="" /locus_tag="" /db_xref="2393044..2393841" CDS complement(8544..9341) /gene="" /locus_tag="" /product="bacterial microcompartments family protein" /translation="MQALGLIETKGLLAAVEAADTMVKSADVSIIEKTYVGGGLVTIS VTGDVGAVKASIEAGVAAVKKLDEGFLVSEHVIPRPHEELESIIGPNTPPEDPSSNDN TENVEDADDTEAVEKAEDTEKVENTKAVDSVEDTESVEVTKDIVDAKNVENTKKAETV KDVKAVDNTEHVDTKNNIKENQHGLDGDLDKLHKLNLENLHKEDVDNLIRQNGIEKTI LILAKLKVVKLRNLAREYKDLGIAGRTISKAGKNLLINKFKLYYEKN" gene complement(9362..10024) /gene="" /locus_tag="" /db_xref="2393862..2394524" CDS complement(9362..10024) /gene="" /locus_tag="" /product="ethanolamine utilization protein EutQ homolog" /translation="MKKLIAAKDIEALILKGEKVLYVDGTEIITPSAKDLVKNNGIVI TTEAPAPKVEHLIGKNVPSIEGIDSEMMLKFLRAMMDKGLLQEMLQCLKGKDLPFKAE CDPNGLKVVRGNSVKMDVFDTGNPNAKVQFQELVSKEESKMSAGFLIIEDSKFDWELT YEEIDYVIEGTLTVEINGKTYTAYPGDVLFVPSGSKVVWGSPDKARVFYTTYPANWAD LL" gene complement(10223..10486) /gene="" /locus_tag="" /db_xref="2394723..2394986" CDS complement(10223..10486) /gene="" /locus_tag="" /product="putative polyhedral organelle formation protein" /translation="MIAARLIDNVWATRKAESLSGLKFMLAEEIGGIDEGRRFIVVDI ISAGIGDRVIVSTGSSARRMLGDDNIPVDAVVIGIIDEDCNFG" gene complement(10483..10785) /gene="" /locus_tag="" /db_xref="2394983..2395285" CDS complement(10483..10785) /gene="" /locus_tag="" /product="hypothetical protein" /translation="VDFRIIKSPSSSTKDILRRRMGGNCKTDLESADAIGLVQGKLID MIYAADIAEKAVGVTVEDIRGTCPQHMVLLGIFGDTSSVEAALNEIKLKMKEVKAI" gene complement(10863..11708) /gene="" /locus_tag="" /db_xref="2395363..2396208" CDS complement(10863..11708) /gene="" /locus_tag="" /product="ethanolamine utilization protein EutJ family protein" /translation="MSEEKLTFEYCDNMVRKFEEVIEKPIVNGSSVYYTGVDLGTACV VLAVLDENYNPVAGAYRYADVVRDGMVVDYIGAVRIVRELKEEIEEKLNTELIYAAAA IPPGTDALDSGAIKNVVQSAGFELTCLLDEPTAANAVLKIQNGAVVDIGGGTTGISIL KDGKVAYVVDEPTGGTHFSLVISGAYEMPFNKADEYKRDNKNHKEILPVLKPVVEKVS SIINNHIKNYDVNEISLVGGTCCLTGIEEIIEKQTGVYTHKPKNPMFVTPLGIALSCT QDIIE" gene complement(11690..12418) /gene="" /locus_tag="" /db_xref="2396190..2396918" CDS complement(11690..12418) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MMKFITEEYLRDLYRKEPFNTYKLEQGQRLTPGAAEYLSDKGIE LSDDSKVNKSSKVNANISPKNSAKTPEETSKETIKDVGNSDVNFNLNKKLCLKLKSME AKFLVVSSEILKEDIILAQNIINLGRKISNIRNVLDGKGTLEPIYLKECTGMNSSNSE ADLDDCFEITEFHMQLPKSNAILKMNVLRCEVQELQLEIIDTYKSDDESLKNKVMDNV NLIINSLSQLICLAVGGKECQRKN" gene complement(12425..12871) /gene="" /locus_tag="" /db_xref="2396925..2397371" CDS complement(12425..12871) /gene="" /locus_tag="" /product="GTP-binding protein, EutP/PduV family" /translation="MRKKRIMVIGPSKCGKTTLVNALNDYDGPLRRTPDLIYGKNTID VPGSYIENAWMYKHIIAAAQDASCVLILVDQSNCTEIYSHGFAKSFRCPVIGVITKCD LMPKNKEKCEMQLKKIGVSEPYFHISFEMGTGIDALKKYLFEKGEE" gene complement(12868..13221) /gene="" /locus_tag="" /db_xref="2397368..2397721" CDS complement(12868..13221) /gene="" /locus_tag="" /product="ethanolamine utilization protein EutS homolog" /translation="MGDFSDRNIQRVIQESVPGKQITIAHVIASPMPDIYDRLGIDEK GAIGILTLSPFETAIIAADIATKASDVEIGFLDRFTGSVVISGDVQSVETALSAVNDT LKDMLGFTTAPITRT" gene complement(13261..14214) /gene="" /locus_tag="" /db_xref="2397761..2398714" CDS complement(13261..14214) /gene="" /locus_tag="" /product="glycyl-radical enzyme activating family protein" /translation="MSNGNLGIIERKARIFNIQKYNMYDGDGIRTLVFFQGCPLRCKW CANPEGLEKKYRVMLKSNLCVNCGACVSACPVGIHTISNKTLKHEVNRDIDCIGCGKC KEACLKSAISIVGEEKTISELLKIVEEDRTFYEMSGGGVTLGGGEVLMQPEAATSLLM ACKQEGINTAIETCGYTKLETILKVAEFVDLFLFDIKNINSDRHHELTGVRNERILEN LQELLKKKYNVKIRMPLLKGINDSQDEIEKTMEFLLPYKDYKNFKGIDLLPYHKMGVN KYNQLGMEYPIKDDPSLKSEDLDRIEGWIKKYDLPVKVIRH" gene complement(14378..16918) /gene="" /locus_tag="" /db_xref="2398878..2401418" CDS complement(14378..16918) /gene="" /locus_tag="" /product="formate acetyltransferase" /translation="LDIREFSNKFMEATKNMSDEERAGLMKMFQSVSNEITREEPATS KVACDNNGEIPDGMTERLVKLKETYLKHVPTITTHRARAITKIAKENPGTPKSVLRGK CFKHCCETAPLVIQDNELIVGAPNGQPRAGAFSPDIAWRWMVDEIDTIGTRPQDPFYI SEEDKKIMREELFPYWAGKSVDEYCEDQYREAGVWELSGESFVSDCSYHAVNGGGDSN PGYDVVLMKKGMLDIKREAEEKLAELKYENPEDIDKIYFYKSLIDTAEGVMIYAKRMS DYAAELAQKETNPKRKAELLKISEINARVPAHKPSTYWEAIQAVWTIESLLVVEENQT GMSIGRVDQYMYPFYKADIEAGRMTDYEAFELSGCMLIKMSEMMWITSEGGSKFFAGY QPFVNMCVGGVTREGRDATNELTYLLMDAVRHVKIYQPSLACRIHKSSPQKYLKKIVD VIRAGMGFPACHFDDVHIKIMLAKGVSIEDARDYCLMGCVEPQKSGRLYQWTSTGYTQ WPICIELVLNNGVPLWYGKQVCPDMGDLSQFKTYEQFEAAVKEQIKFITKWTSVATVI SQRVHKELAPKPLMSMMYEGCMENGRGVEAGGAMYNFGPGVVWSGLATYADSMAAIKK LVFEDKKYTLQEMNEALKADFVGYEQLRKDCLEAPKYGNDDDYADLIAADLINFTEQE HRKYKTLYSVLSHGTLSISNNTPFGQMTGATANGRRAWMPLSDGISPSQGADFKGPTS IIKSVSKMSCEDMNIGMVHNFKLIAGLLDTPEGEQGIITLLRSACALQLGEVQFNYLD NKTLIEAQKHPDQYRDLIVRVAGYSAFFVELCKDVQDEIISRTMLTHF" gene complement(16968..18461) /gene="" /locus_tag="" /db_xref="2401468..2402961" CDS complement(16968..18461) /gene="" /locus_tag="" /product="aldehyde dehydrogenase family protein" /translation="MNIIDNDLLSMQEARILVENAREAQKKLATFPQEKLDEIVERMA EEVEKHLKELAKISNEETEYGKWQDKYVKNHFVCEYLKNKLKGMRCVGIINEDKINKT MDVGVPMGVVIAFPPATSPVSTTIYKALIAIKSGNAIIFSPHKRAKNTISKTVDILIR AAEGVGLPEGALAYLHTVTESGSLELMKHKDTSLIMNTGVIEMLDEAYKSGKPVIYGG NGNGPAFIERTADIEKAVKDIITSKNFDYGIVSAAEQSIVVDSLIASEVKQELIKNGG YFMTEEEALKLGKILFNQNGSPDLEMIGKSPQFLAKKAGFEVSEGVKVLISNEKFVSK NNPYSREKLSPVLAFYIEDDWMHACEKCIELLLTERYGHTLVIHSKDEEVIRQFALKK PVGRVLVNTAGTFGSMGATTNLFPSMTLGSGSAGQGMTSDNVSPMNLLYIRKVGYGVR MVDEIVKTVNDKEDSIPAVLNGKLNGNEIDNYKLLESILKKVLQDLK" ORIGIN 1 aagagggttt tactcccact aaagcttaga aatcattctc tttggtcatg gtcattcttt 61 accccacttt aaataaaatt gaaatattat agctagcaat cttaggataa gctatttaaa 121 cagaaaaaga gcatcctaaa ggctgctctt taacattatt ggttatattt tataataatt 181 atatgaatga gttttattct tgttttaact ttattaatat actaattcta gcttattaat 241 tcccaaggtg tctcccatgg attttgtact tttgtatctg gagcaaagcc ttgtgaccac 301 cattttgctt tataagtctt ttctttatag ctaaccttat ctcctgcgtt atagctttta 361 ttagggttcc attcattttc aggtgattta ttaatttcat cttcagatga ttttactagt 421 ccagtatcag taattttgta agttatacta ttgccttttt ctagttctaa ttcattttct 481 gtatttgtaa ttaataatct attgtctggt tcttgatgtt ttattgtaat atagtatcca 541 ggtttaatat caatattttt aattaatgtt tcattttcct tatcgccaat aaaatctttt 601 gtataaacag tatttccttc agcacttctt attaaaattg atgcataagt atcagaaaaa 661 taaacatgag gttcaccttt ttttatatct attttagctt gtttagaagt taaatctaaa 721 tttaactctg caaaaatcca atctcctaag cctttaaaag tagcattaaa ttttttacct 781 agataaggat tttctttatt tattgttgaa tttggtaaaa ggtccttgta ttttgttaac 841 atttcacttc ttaaaggttc tgttaaggca tctattgcta gtttcaactc tatcttagac 901 tctgcacaat cacttttagc cataagattt tcagcgttaa ttttcgctgc aaaactatca 961 attcttccag ccaattcttg atttaagttt tggtttaagt tttcattttt aagtccttgg 1021 ctagtaacaa tcaatgtatt agtctgatta ttagtaagaa cagttttgtt atctctaatt 1081 tttaaacgtg atggttcacg gtgatatagc ctaatcttat atcctttctt taaagtttga 1141 ctactatttt ctaatgctgc atttgtacca gtaattactt ttgtataagt aacattatta 1201 ttttgatcta agatctcaat tttagcatac tgttcatttg ggaaataatc atgtggtgtc 1261 ttattaagaa ctttcacatt tagcttttca ttttgtaaat ccacagtagc tgtagcaaat 1321 aaattatcgg atattcctaa aaaatctatt tcttgattta ctaaagtact ttttgtacgt 1381 aatttataat ttaaagttat attattatta gcttctttaa cttttaaata atggttatca 1441 agtgtatata atttattaga actatttgta ctataaatag tataaatacc tactggcaac 1501 tgacctagag aaagagttgg atttgtaata acaacctttt taacttcttt ttctccattc 1561 attatataaa gggtttgatt tttaatttga ttaaaatcat caattttaaa atttaaagtt 1621 acatcccctg ttaaatcagt agcagctaaa tcctctgtag ttactaaaga taatggagtt 1681 tctaatttta atgattgttg tatttgagaa acctgactaa caggaacaac ctcatttaat 1741 ggtgcaacag gtttgtaatt tttatatcta ttttcttcct tttgccaatc tgtcatagtt 1801 ccaccaaagg attctataac tggtgtaaaa tctagtttgc ttatttcacc atagcattta 1861 cttattaaat caaattgttt atagtcggat gtattaaaac cagaagtatt tgctaattta 1921 cgatattctt gattaaaatg agtaaaacta tcatctccag ctttatcctt cataagtaca 1981 tatccatata gctgctctct taatccccaa gtattaaaag ctgctttatc ttgatgccaa 2041 agtttattta cattataatc aacggcatct tttttgccat aatcatataa ccatccattt 2101 ttaaaaatat ctacatctga atcttttttc tgaagactat gagcatatat attattccaa 2161 acttcccctc tagtgaaatc gtcttgatat ccatgaccaa tttcatgtaa ggctccccaa 2221 ccttttgtta accaaaagct agctactgaa tctgaagttt ctgcagtatg attgccacca 2281 taataaccac caccaggacc actcttgtca gcttttataa aatatttatt aggaacattt 2341 ttatcagttt gaacatttgt attaaaactg attccagcta gcttattgta atactcaaat 2401 atttcacgat aataaagaat taattgatca atagaagaaa aatctttcat atttttcatg 2461 taagctttat ctttttgtgg aactaataat tgaaaatagt catcttttac taaagcaaaa 2521 ggagctgctg ctttgtccca ctcattaaaa aatgattgtt cattttgtcc ctttttataa 2581 ataggcaaag tttgcatgct gctagttacc ctatattcaa ttttaggttt ttcactacca 2641 ccataaaccg tatccacaaa tggaactgaa ctatatggag ttgatatagt aattgatgtt 2701 tgattaaatg ttctagatgt ctcatgttga ttattatcat ttaataatct tacagttaaa 2761 ttccctttaa aattaggatt tacctgtcta attgttagct gtacatttgc aggtaagatt 2821 atacctaaat cttgcttatc atgaccaagt cctttagaaa aaccagtttt tttaaaccaa 2881 gtaggatttt ctaaggtata aagttctttt tgctttactt catcagcata aacatttgtt 2941 gcagttccaa atatagcaca aatgaataat gcttgaagca ttaaaaattt cataaaacct 3001 ttcattggct tgtccccctt ttattgtaac ttaagtctgt taaatcagat aaattttaaa 3061 atatgacaat aaatatacaa tatatttttt aatacttatt aacagacata aattgtatat 3121 taaaattcat ttatatatta ataacaaaaa atgaatttta aaccatatat tatatttttc 3181 gaattaaaat tataaaattt aatacaaaat ttaatataaa tataagattt ataaataaaa 3241 tatactattt tataataatg gactaaaata tgtaagtaag agcgcggaaa atacttataa 3301 tatgattaaa gcttatcata gatatgttta tttttaacta aagtaatata aatggttatt 3361 ttataacctg tggtattcag aacacaataa aaacgccgct aaattatctt tagcgacgtt 3421 ttcttatttt cgctgtaatt aacatcttat ttaattgatt tctttttcca tttaagcaat 3481 aatgcagaat taataataac aagtacagag cctgcattat gaacaagggc acctactata 3541 ggattaagta ctcctgttat tgcaagtata attgcagcaa aattcagtat cattgaaaag 3601 ctcaagttaa tcttgatggt ggtcatcatt tttttcgaaa gttcaaataa atggggaagc 3661 tgactaatat catcactgac aagtgcaata tctgcagcat ctacagcaat atcgcttcct 3721 acacctccca ttgcaatacc tacataagcc tttttcaatg caggtgcatc attaacacca 3781 tcacctacca tacagaccat ctctctacca atttggatat tatggattgt atcaagctta 3841 tcttctggta aacaatctgc ttttacctca gaaatactaa tcttattaga tatatatcta 3901 gcagcttcag catggtctcc tgtaagcaaa acaggggtta ttccaagagc tttaatattt 3961 cttatcatat atggagcatt tttacgtaat gtatcggata aaacagaaaa accaaccata 4021 atattgtcta ttgctatgta aataatagta catccttttg aaagataaga ttctgcttcc 4081 tttagtactt catcttttaa agaaatatga ttatctttca ttagtttctc gtttcctgca 4141 aaaatttttt tcccattgac ttttgccaaa acacctcttc ctggaagcat agtaaacttt 4201 tcaggttctg tagatatatt cccagtctgt ctaaaacact ctacaactgc ttttccaagg 4261 ggatgttcac ttctcagttc tgcagatgct aatacttcat acaaatcttc atctgtatag 4321 ttatctgaaa agctttttac tgttacaatt tctggtttgc cgtaagttaa ggtacctgtt 4381 ttgtcaaaga caattttctt tacctttgaa agtcgttcca gtgcatcacc ttcacgaact 4441 aagataccat attttgtagc attgccaatt gcggccataa ttgcagttgg tgtagcaagc 4501 actaaagcac atggacaaaa tacaacaagg attgttacag cacggataat ctctcctgta 4561 ataatccagg tgagaattgc tgcggtaacg gcaataacta caatccaagt tgcccatcgg 4621 tcagcaatgc caactatttt tgacttgcct gcatcagcag attgaacaag tcgtatcata 4681 cgctgtagtg aactatcctc tccaacttta atggctttca tttcaaatgt accaaactga 4741 ttaactgttc cacttgatac ttcatctcca agagatttgt ccacaggcat agattctcct 4801 gtcataacgg actgatcaat agatgtttgt ccctttgtaa tgattccatc aactgcaatt 4861 gtctctccag caagaacacg caagatatca ccaacctgga ccttttttgc atcaataatt 4921 tcttctttgc ctcctcggat aattcttgca gttcgcggtg tcagatgcac taatttctca 4981 attcctgcct gtgcttttgc cacagtaagt tcttcaagta atgcacctat ttgcataata 5041 aaaactacct caccagcggc aaaaatttct ccaataataa cagatgcaat aagtgccatt 5101 gaaacaagca catcagcctt tatatcaaat tctgtaataa gtcccttgat agctccaata 5161 ataataggag ctccgcaaag aacaatagaa atccacgcca cattaacagg taaatggccc 5221 acatcaaaaa aactaactat aagagcaata ccggataaaa caagaaaaaa tatgtttcgt 5281 tttgtttcat cagtaaaaat agattttaca ttattcaagt tataacactc cttccatacc 5341 tataggggta tatgtacatt gtacccttat gggtataggt atgtcaataa aaaaagagca 5401 aactaaaaaa taatttaata gttgctcttc taatgaaact tttataaaga taaaacttta 5461 gtgattataa attttttaat taatatacta ttcatcttat caagacatat ttgaaaaacg 5521 ttcaacagct tttgcaaaac ttttaatagt tctatctgca tcaccatgct caattccttc 5581 acgtacgcag tgttgtaagt gaccttcaag tacaacctga cctgatttat gaagtgcaga 5641 ttttgctgca ttaatttgca tcaatatatc ctcacatgga acatcttcgt ctatcattct 5701 atcgatagca tttatttgcc caattatttt ttttaatctt ctatgtaagt tttcagaatc 5761 catacatttt ttcataaaaa cacctccaca tacccttagg ggtatgtgta tattatactg 5821 attaatctac cacctgtcaa tggaataatg aaaaacgccg ctaaattaga tttagcgacg 5881 ttttcttatt ttaaatctta ttttgcaact tctttagatg atggaagaat tacttcaact 5941 tcagagtgtg gacgtggtat aacgtgaact gatactaatt ctccaacacg ttgtgcagct 6001 gcagcaccag cgtctgtagc agctttaaca gctccaacat cacctctaac cataacagtt 6061 acaagtccgc ctccaacata ttctttacct attaaatata cgtttgctgc tttaaccata 6121 gcatctgctg cttctattga tcctactaac ccttttgttt ctatcattcc taatgcatca 6181 tatttcattt taaaatcctc ctaaaatatc tttttttatt tatttaaatt tttaattata 6241 agcaattatt tatttaattt tttattttac tattgttact tttgactttg aattaatacc 6301 cattgcgtta gcttcttcaa tatcaagatg acattcaagg cttgaagcgt cattagctct 6361 aacagctaca ttattgtata ttccgcctct taaatcttca aattttattg acactatttc 6421 tccatcatgt actcctaaat tttgagcatc ttcaggcgtc atgtgaatgt gtctttgggc 6481 gactattaat ccttcttcta gttgaacaga accctttggt ccaactattg taataggaga 6541 tgttctattt aaatctccag ataattttac atgagatact gctccaagct taatgcagtc 6601 tccagctaat acttcaacct gagtcttgct tcttacagga cctaagattc taattttttc 6661 aattgcaccc tttggtccac aaattgttac aacttctttg caagcatatt gtccaggttg 6721 agataaatct tttatcttag taagcccata attttcacca aaaagactat ctaaatcctt 6781 ttgtgaaaga tgtatatgtc tattagaaat ccctactgga atctcagatg aatttctatt 6841 aactgcatta tttaattctt tacctttaac agcttctagt aaaagtttta atacttcttc 6901 acaattatcc attagtttgc ccccttcata gcggcaacta tttgattaac taaatctaaa 6961 agttcttcat tttttgtatt ttcattactg cattcagtgc aagtattagt gttttcagcg 7021 caattattag ccttatttaa aacttctgca gctgctgcaa tttgtgctgg gctcatattc 7081 ataaattgat tttgaactcc atgacagttt tcagcagttt ttatgcagtt aaaagttggg 7141 tcattagatg ctaaatttgt gcaatctttt ataccataag caactctttt aatgttcata 7201 aggtgctttg gagtaacatt ttcagatact gagcttcctc cccaagtacc gcatcctaaa 7261 gtaaatgaag gattaagacc tgtacttgca cctgttccac cttgagttcc accagtgtta 7321 acaaggatac gggaagctgg ttttctagca aacttcataa ccatgtctct atcttctgta 7381 tggatactca ttgtgtgacc aattccattt tgaagtaatt taatacttaa ttcacatgct 7441 tcatgccaat cttttactgt atagaatcca agaactgttg taagtttttc aaaagataat 7501 gggtaacctt ctcctactcc attttgtctt cctataagta ctttagttcc tgctggaatt 7561 gtgaatcctg cagcacttgc tataacttgt ggacttcttc caacaaattt agcattcata 7621 gcattacctt ttttgaataa tagtttacaa actttttcag tttcttcttc tgtcatgaag 7681 tatccacctt gttttttaaa ttctgcaaca actaggtcat gattacattc ttcacagatt 7741 attgattgtt ctgatgcaca gattgtacca ttatcaaaag ttttacttgc aataatgttt 7801 ttaacagctt tttctacatc agcagttctt tcaatgtatg ctggagagtt tcctgcacca 7861 acaccaatag ctggtgttcc tgagctataa gcagctttaa ccattcctgg accacctgta 7921 gctattatta tagctacttc tttgcttttc attaattcat ttgtagctcc aattgttgga 7981 atagttacag cacttataat gttttctggt gctccagctt ctattgctgc atccctcatt 8041 aattcaactg ctttaattgt acattttgca gcagctggat gtggtgcgaa tactatagca 8101 ttacgagatt tgattgaaat catagctttg aaaattgcgg tagaagttgg gtttgttgaa 8161 ggtactatac ccataactaa gccaactggt tcagcaagtt ctataagctt attttcctta 8221 tcttcattaa ttacacctat agttttcata tctttaattg aattataaag tatagtagct 8281 gctaagtgat ttttgaaagt tttatcttca actttaccaa agcctgtctc ttcaactgcc 8341 atttgtgcta aacaaacagc gttttcttct gcaactctta ccatattacg taaaattttg 8401 tcaatttgct cttcagtata atcagcaatt ttatcagctg ctacttttcc aagtctagca 8461 agatctctcg cttgttgtat tgaacgcaaa tccttatcaa agttttccat tattccttac 8521 ttcctttcgt aacctttaaa atagctaatt tttctcgtaa tataatttaa atttgttaat 8581 taataaattt ttacctgctt ttgaaattgt tctacctgca attccaagat ccttatattc 8641 acgagctaga tttctaagct taacaacttt tagcttagct aatattaaaa tggttttttc 8701 tataccattt tgtcttatta aattgtctac atcttctttg tgtagatttt ctaaatttaa 8761 cttatgtagt ttatctaaat ccccatctaa tccatgttga ttttctttaa tattattctt 8821 agtatctaca tgttctgtgt tatctacagc ttttacatct tttacagttt cagctttttt 8881 tgtattttct acattctttg catctactat atcttttgta acttctacgg attctgtatc 8941 ttctacactg tctacagctt ttgtattttc taccttttct gtatcctctg ctttttctac 9001 agcctctgta tcatctgcat cttccacatt ttctgtatta tcattagatg atggatcttc 9061 tggtggagta ttaggtccta ttatgctttc cagttcctca tggggacgtg gaattacatg 9121 ttctgaaact aaaaatcctt catcaagttt ttttacagct gctactccag cttctataga 9181 tgcttttact gcacctacat cccctgtaac tgaaattgta acaaggccgc cacctacata 9241 agttttttcg ataatactta catctgctga tttcaccatt gtatcagctg cttcaacagc 9301 tgcaagtaat ccctttgttt ctattaaacc aagcgcttgc ataggtaaat cctcctaatc 9361 ttctataaaa gatccgccca atttgctgga tatgttgtat aaaataccct agctttatct 9421 ggggatcccc aaaccacttt agaacctgat ggtacaaaca atacatctcc aggataagct 9481 gtatatgtct ttccattaat ttcaacggtt aaagttccct caatgacata atcaatctct 9541 tcgtaagtta attcccaatc aaattttgaa tcttcaataa ttaaaaatcc tgcactcatt 9601 tttgattctt ctttacttac caattcttga aattgaacct ttgcatttgg attaccagta 9661 tcaaatacat ccattttcac tgaatttcct ctaacaactt taagtccatt aggatcacac 9721 tcagctttaa atggaagatc cttccctttt aaacattgaa gcatttcttg tagaagaccc 9781 ttgtccatca ttgctctaag gaatttaagc atcatttcac tatcaatgcc ctctatactt 9841 ggaacatttt tacctattaa atgctctact ttaggtgcag gagcttctgt agtaattact 9901 attccattat tttttacaag atccttagct gatggtgtta ttatttcagt accatctaca 9961 taaagtactt tttcaccctt taatattagg gcttcaatgt cttttgcagc gattaatttt 10021 ttcatgttct cacatccttt caaactttca aataatatca aaatctctat ataaaactcc 10081 ttctcctatt atggagtgag caagctagca tatcaaaatc aacactcttt gtaaatgatc 10141 acttcaaaat tgtagatttt gcatgcttat ttaagatttt gcatgtgttt taaatattat 10201 gtttatttta agaaagttgt gttttaacca aaattgcaat cctcatcaat tattccaata 10261 acaactgcat ctacaggaat attatcatca cctaacattc tgcgagcaga tgatccagta 10321 ctaacaataa ctctgtcacc aatacctgca ctgataatat caacaacaat aaatctgcgt 10381 ccttcatcta tcccgccaat ttcctcagca agcataaatt taagtccgct aagggattct 10441 gcttttctag tggcccatac attatcaata agtcttgctg ctatcatatt gcttttacct 10501 ctttcatttt taatttaatc tcatttaatg cggcttcaac tgatgatgtg tcaccaaaaa 10561 taccaagtaa aaccatgtgc tgaggacatg tacctctaat atcttcaacg gtaactccaa 10621 cagctttctc agcaatatct gcggcataaa tcatatcgat aagtttacct tggacaagtc 10681 ctattgcatc agcactttct aaatccgttt tacaatttcc acccattcgt cttctaagaa 10741 tatctttagt gctactagaa ggtgatttta taattctaaa atccactttt aaacactctc 10801 cttattaggc acatgaaaat aaataacaag tcaaagatgg cagtatattt attttcatgt 10861 gtcttattct ataatatctt gtgtacagct taatgctatt ccaagtggtg taacgaacat 10921 agggttttta ggcttgtgag tatatactcc tgtctgcttt tcaataattt cttcaattcc 10981 tgttaaacaa caagtaccac ctactaaaga aatttcatta acatcataat ttttaatatg 11041 attattaata attgatgaca ccttttcaac cactggtttt agtactggta aaatttcctt 11101 gtgattttta ttatctcttt tgtattcatc tgctttatta aaaggcattt catatgcacc 11161 tgaaataact aatgaaaaat gagtaccacc tgtaggttca tcaacaacat aagcaacctt 11221 tccatctttt aaaattgata ttccagttgt tccaccaccg atatctacaa ccgcaccatt 11281 ttgaatttta agtacagcat ttgcagcagt aggttcatct aaaagacatg tcaattcaaa 11341 tcctgctgat tgaactacat ttttaattgc tccagaatct aaggcatccg ttccaggtgg 11401 aattgcagca gcagcataaa tgagttctgt atttaatttt tcttcaattt cttctttaag 11461 ttctctcaca atccttactg ctccaatata gtcaacaacc ataccatcac gaactacatc 11521 agcatatcta tatgcacccg ccactgggtt gtagttttca tctaaaacag ctaataccac 11581 acaggcagta cctaggtcca cacctgtgta ataaacagaa gacccattaa caattggttt 11641 ttctataact tcttcaaact ttcgaaccat attatcacaa tattcaaaag ttaatttttc 11701 ctctgacatt cttttcctcc tactgctaaa caaattaatt gggacagtga attaattatt 11761 aaattaacat tgtccataac tttgtttttt aaactttcat catcactttt atatgtgtca 11821 attatttcaa gctgtaattc ctgcacctca caacgaagta cgttcatttt taaaattgca 11881 ttgctttttg gaagttgcat atgaaattct gttatttcaa aacaatcatc aagatccgct 11941 tcagaatttg atgaattcat cccggtacat tcttttaaat aaataggttc aagagtacct 12001 tttccatcta aaacatttct gatgtttgat attttcctac ctaaatttat aatattctgt 12061 gctaaaataa tatcttcttt taatatttca ctactaacaa caagaaattt agcctccatg 12121 gatttcaatt ttaagcaaag cttcttattc aaattgaaat ttacatcact atttcccaca 12181 tcttttattg tttctttaga tgtttcttcc ggtgtttttg ctgagttttt tggggaaata 12241 ttcgcattta cttttgaaga cttatttact tttgaatcat cactcaattc tattccttta 12301 tcagataaat actcagctgc tccaggggta aggcgctgtc cttgttctaa cttgtaggta 12361 ttaaaaggtt cttttctata taaatctctt aaatactctt ccgtaataaa tttcatcatt 12421 gacctttact cctcaccttt ttcaaataaa tactttttta aagcatcaat tcctgttccc 12481 atttcaaagc taatatgaaa atatggctct gataccccta tcttttttaa ctgcatttca 12541 catttttctt tattcttagg catcaaatca cattttgtta taaccccaat tactggacat 12601 ctaaaagact ttgcaaatcc atgggagtat atttcagtgc aattagattg gtcaaccaat 12661 ataagcacac aagatgcatc ctgagctgct gcaattatat gtttgtacat ccatgcattc 12721 tctatatagg aacctggaac atcaatggta ttcttaccat aaattaaatc tggtgttcgc 12781 cttaatggac catcataatc atttaatgca ttaactaatg tagttttgcc gcattttgaa 12841 ggtccaatta ccattatgcg cttttttctc atgttcttgt aatgggagcg gtggtaaatc 12901 caagcatatc ctttagcgta tcattaactg cactaagagc tgtttcaaca ctttgaacat 12961 caccacttat tacaacagag cctgtaaaac gatcaagaaa tccaatttca acatcagaag 13021 ccttcgtagc aatatctgca gcaataatag cagtttcaaa gggcgaaaga gttaaaatac 13081 ctattgctcc tttttcatca attccaagac gatcatatat atcaggcatt ggtgatgcaa 13141 taacatgagc tatagtaatc tgctttcctg gcactgactc ttgtataaca cgctgtatat 13201 ttctatcaga aaaatctccc ataaacctta ccttccatct tattatctat ttgaaaatta 13261 tttaatggcg gattaccttt acaggtaaat catatttttt aatccatcct tctattctat 13321 ctaaatcttc acttttaagg cttggatcat cttttatagg atattccatt cctaattggt 13381 tatatttatt tacccccatc ttatgataag gaagtaaatc aattccctta aagtttttat 13441 aatctttata aggtaataaa aattccatag ttttttctat ctcatcttga gaatcattta 13501 tacctttaag taaaggcata cgaatcttta cattgtattt tttcttgagt aattcttgaa 13561 gattttctaa aatcctctca tttcttactc cagttaattc atgatgtcta tcagaattaa 13621 tatttttaat atcaaataag aataagtcta caaattctgc aaccttaagg attgtttcaa 13681 gctttgtata gccacaagtt tcaattgcag tgtttatacc ttcttgctta catgccatta 13741 gtaaactagt agcagcttca ggctgcatta aaacttcgcc accacctaat gtaactccac 13801 cgccggacat ttcataaaag gttctatctt cttctactat ttttaaaagt tcagagatag 13861 ttttttcttc tccaactatt gatatagcag atttaagaca agcttcttta cactttccac 13921 atcctataca atctatgtca cgattaactt catgctttag agttttatta gaaatagtat 13981 gaattcctac aggacatgca gaaacacaag ctccacaatt tacacataga ttacttttaa 14041 gcataactct atattttttt tctagtcctt caggatttgc acaccattta catctaagtg 14101 gacatccttg aaaaaatact aaagttctta ttccatctcc atcatacata ttatattttt 14161 gtatattaaa aatccttgct tttctctcga ttatacctaa atttccatta ctcatattac 14221 tcattctcca gtttcattta ctttgatttt taatatatat cttaatttac atctgcaatc 14281 tacaaaacag gctgtagatt gcagacttta tataaattat tttaaaggga ctaagttata 14341 tattttctat aagttatata ttttccatca aatttttatt agaaatgtgt aagcatagtt 14401 ctacttataa tttcatcttg aacatcttta cataactcaa cgaagaatgc actgtatcca 14461 gcaacacgaa caattaaatc acgatattga tctggatgtt tttgagcttc tattaaagtc 14521 ttgttgtcta aatagttaaa ttgaacttct ccaagttgaa gggcacaagc actacgtaat 14581 aatgtaatga ttccttgttc tccttctggt gtatcaagaa gaccagctat taacttaaag 14641 ttatgaacca tacctatatt catatcttca caagacatct tagaaacaga ttttattata 14701 gaagtagggc ctttaaaatc agcgccttgt gatggactta taccatctga taaaggcatc 14761 catgctctac gtccatttgc tgtagctcca gtcatttgtc caaatggagt attgtttgat 14821 attgataaag taccatgact aagtactgaa tataatgttt tatatttacg atgttcttgt 14881 tctgtaaagt taattaaatc agcagcaatt aaatctgcat aatcatcatc gttaccatac 14941 ttaggtgctt ctaaacaatc ttttcttaat tgttcatatc caacgaaatc tgcttttaaa 15001 gcttcgttca tttcttgtag agtatatttt ttatcttcaa atactaattt ctttatagct 15061 gccatggaat ctgcataagt agcaagtcca ctccatacta ctccaggtcc gaagttatac 15121 atagctccgc cggcttctac ccctctacca ttttccatac aaccttcata catcatagac 15181 ataagtggct ttggagcaag ttctttatga acacgctgag aaattactgt agcaacactt 15241 gtccatttag taatgaattt gatttgctct ttaacagctg cttcaaattg ttcataagtt 15301 ttaaactggc ttaagtctcc catatctggg catacttgtt taccatacca taatggtaca 15361 ccattgttta aaacaagttc tatacatata ggccattgag tgtatcctgt agaagtccat 15421 tgatatagtc ttccggattt ttgtggttca acacaaccca ttaagcagta atctcttgcg 15481 tcttctatag aaacaccttt agctaacata atttttatat gaacatcgtc aaagtggcat 15541 gctgggaatc ccatacctgc acgaataacg tcaactatct ttttaagata tttttgtggt 15601 gatgatttgt gtatacggca agctaaagat ggttgatata ttttaacatg acgaactgca 15661 tccattaaaa ggtatgttaa ttcgtttgta gcatcacggc cttctctagt aacaccacct 15721 acacacatat ttacaaatgg ttgataacct gcgaagaatt tagaaccacc ttcacttgtt 15781 atccacatca tttcagacat ttttataagc atacaacctg ataattcaaa tgcttcataa 15841 tcagtcatac gtccagcttc aatatcagct ttgtagaatg ggtacatgta ttggtcaaca 15901 cgtcctatag acatacctgt ttgattttcc tcaactacaa gtaatgattc tatagtccaa 15961 actgcttgaa ttgcttccca ataagtactt ggcttatgtg ctggaactct agcatttatt 16021 tcagaaatct ttagaagttc tgctttacgc ttagggttag tttctttttg agctaattca 16081 gcagcataat ctgacatacg tttagcatat atcataacac cttcagcggt atcaattaat 16141 gatttgtaga aatagatttt atctatatcc tctggatttt catatttaag ttcagctaat 16201 ttttcttctg cttctctctt tatatcaagc ataccttttt tcattaatac aacgtcatat 16261 cctgggttag agtctcctcc accatttact gcgtggtatg aacaatctga aacaaaagat 16321 tctcctgaaa gttcccatac tcctgcttca cgatattgat cttcgcagta ttcatcaacg 16381 gatttacccg cccaatatgg gaataactcc tcacgcatga ttttcttatc ttcttctgat 16441 atatagaatg gatcttgtgg acgagttcct attgtatcaa tttcatcaac catccatctc 16501 caagctatat caggagaaaa tgctcctgca cgaggttgtc catttggtgc tccaactata 16561 agttcattgt cttgaattac aagtggtgca gtttcgcaac aatgtttaaa acatttacca 16621 cgtaaaactg atttaggagt accagggttt tcttttgcta ttttagtaat agctcttgct 16681 ctatgagttg ttattgttgg aacatgtttt agataagttt cctttaactt aactagacgc 16741 tctgtcattc catctggtat ttcaccatta ttatcacacg caacctttga tgtagctggt 16801 tcttctcttg ttatttcatt agaaacactt tgaaacatct tcattaatcc agcgcgttct 16861 tcatcagaca tatttttagt agcttccata aatttatttg aaaattcacg tatatccaat 16921 ttattccctc acattcttta atgtatttca tatattaaat atgatttttt attttaagtc 16981 ctgtagaact ttttttaaaa tactctctaa taacttatag ttatctattt catttccatt 17041 taacttccca tttaaaactg cagggataga atcctcttta tcatttactg ttttaacaat 17101 ttcatccacc atgcgaactc catatccaac tttacgtata tataatagat tcataggtga 17161 aacattatcc gaagtcattc cttgacctgc agaaccacta cctaatgtca ttgaaggaaa 17221 caaatttgta gtagctccca tgcttccaaa agttcctgca gtatttacaa gtactctccc 17281 aacgggtttt ttaagtgcaa attgacgaat aacttcttca tcctttgaat gtatcacaag 17341 tgtatgtcca tatctttcag taagtaataa ttctatacat ttttcacaag cgtgcatcca 17401 gtcatcctct atataaaagg ctaaaaccgg agaaagcttt tcccttgaat aaggattatt 17461 tttagaaaca aacttctcat tggaaataag cacttttaca ccttctgaaa cttcaaagcc 17521 agccttttta gctaaaaatt gtggagactt accaatcatc tctaaatctg ggcttccatt 17581 ttggttaaac aaaatctttc ctagttttaa agcttcttct tccgtcataa aatatccacc 17641 atttttaata agttcttgct ttacttcaga tgcaattaag ctatctacaa caattgattg 17701 ttctgcggca gatacaattc cataatcaaa attcttgctt gtaataatat ctttaaccgc 17761 tttttctata tcagctgtac gttctataaa ggcaggtccg tttccattgc ctccatatat 17821 tactggctta ccagatttat aggcttcgtc aagcatttct ataactccag tgttcattat 17881 taaagatgta tctttatgct tcataagctc taatgaacca ctttcagtta ctgtgtgaag 17941 atatgcaaga gcaccttctg gaagtcctac accttctgca gctctaatta aaatatccac 18001 tgttttagaa attgtatttt tagctctttt atgaggtgaa aatataatcg catttcctga 18061 ctttattgca attaatgctt tatatatagt ggtagatact ggacttgttg ctggtgggaa 18121 ggctataaca acccccattg gtacaccaac atccatggtt ttattaattt tatcttcatt 18181 gataatacct acacacctca tacctttgag tttgtttttt aaatactcac atacaaagtg 18241 atttttaaca tatttatctt gccactttcc atactctgtt tcttcattag atatttttgc 18301 aagctctttt aaatgttttt caacctcttc agccatacgc tcaactatct catcaagttt 18361 ttcttgtggg aaagtagcta attttttttg tgcctctcgg gcattttcaa caagaattct 18421 agcttcctgc atggagagta aatcattatc tataatattc at //