LOCUS NC_012563:25 18739 bp DNA linear BCT 26-AUG-2011 DEFINITION Clostridium botulinum A2 str. Kyoto, complete genome. ACCESSION NC_012563 SOURCE Clostridium botulinum A2 str. Kyoto, complete genome. COMMENT locus start: 3416509; locus end: 3435247 FEATURES Location/Qualifiers source 1..18739 /organism="Clostridium botulinum A2 str. Kyoto, complete genome." gene complement(0..1274) /gene="obg" /locus_tag="obg" /db_xref="3416509..3417783" CDS complement(0..1274) /gene="obg" /locus_tag="obg" /product="Spo0B-associated GTP-binding protein" /translation="LFIDTAKIFVKSGKGGDGSISFRREKYIAFGGPDGGDGGKGGNV VLVVDPNMTTLLDFTYKRKYKAEPGGNGAGSKCFGKNGKDLHIKVPMGTIVKDAETDK IMADLSKPEDSYVVAKGGRGGKGNCRFTTPTRQAPDFAEPGMPEEERWIKLELKLLAD VGLIGFPNVGKSTLLSVVSKARPKIANYHFTTLKPNLGVVSIEGVNNFVIADIPGIIE GASEGVGLGLDFLRHVERTRVLIHVIDISSVEGRDPYDDFLKINDELKRYSVKLYDRP QIIAANKSDMLFDEEKFEEFKTKVEKHGYNKVFKISAATKQGVDDLMKEAARLLSTIP VTDLEISEEDRFIEEEKRFTYSIRKEDNTYIVEGSFVDRLLNAVNVNDPDDLRYFHKV LKNKGVMEELMEMGIEDGDVVRLNDFEFDFLL" gene complement(1653..1955) /gene="rpmA" /locus_tag="rpmA" /db_xref="3418162..3418464" CDS complement(1653..1955) /gene="rpmA" /locus_tag="rpmA" /product="ribosomal protein L27" /translation="MLVMNLQLFAHKKGVGSSKNGRDSEAKRLGVKCSDGQFVLAGNI LVRQRGTKIHPGLNVGRGGDDTLFAKIDGVVKYERLGRDKKKASVYPVEVEEVVAE" gene complement(1958..2284) /gene="" /locus_tag="" /db_xref="3418467..3418793" CDS complement(1958..2284) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MVNVVFKKENNDIVFVKMSGHAGSTDQGYDMVCSAISAVSITIA NGITEVLKINPLIKEEDGFLSIDLRSCIKEDIHKCQVLMSTMLLGLKSIEFNYSEYIK LTMEEV" gene complement(2287..2601) /gene="rplU" /locus_tag="rplU" /db_xref="3418796..3419110" CDS complement(2287..2601) /gene="rplU" /locus_tag="rplU" /product="ribosomal protein L21" /translation="MYAVVVTGGKQYKVAEGDVLFVEKLTADVDSTVELDNVLLVGKD NEETVVGKPMVEGAKVTAKVLAQGKAKKVVVFKYKPKKDYRKKQGHRQPYTKIQIEKI NA" gene complement(2725..4164) /gene="" /locus_tag="" /db_xref="3419234..3420673" CDS complement(2725..4164) /gene="" /locus_tag="" /product="ribonuclease, Rne/Rng family" /translation="VKEIFIERQRENVRIVLRESNHIKELFIEEDNKSPQVGEIYVGM VKNIIPAIKSAFVDIGWNKNAYLYLDKKFNNTHIKKGDYILVEVVKEDLNKKGPKVTN AITIPGRYTVLQILNNEITFSHKIKDEKIRTEIQNNIVKPKDVGILIRTEAINTSIEN INNEIRRLYKIYSSLIEKSKYKMNTGVLFQNGGIVGKILRDKLNDNISKIYLNCREDY VYVSEFLKEYGENNIKLDIYEGERNLLDYYAIEKEILSLRNKKVYLNCGGYIIIDKTE AMYVVDVNSGKNVKGNSMEKTIFTTNMEAADEICNQIILRNLNGIIVIDFIDMDNENL KEKVLDKLKQGLKRDKNKSVVYPFTELNLVQIARKRQGKTIYDYIEQPCKCCSGKGSI VSFTYMKLLIRNEIINILNMREIKDIYIELNKRYKDYIDKNRIQFISEIEALEKNIYI NYIDAENQYKVEPLIFKNQIEDVKDLKIY" gene complement(4203..4916) /gene="" /locus_tag="" /db_xref="3420712..3421425" CDS complement(4203..4916) /gene="" /locus_tag="" /product="hypothetical protein" /translation="LKVRYLIKFSKEGNIKFVSHLDLQRTLQRNFKRSGLPVEYSKGF NPHIIMSLAQPLAVGLYSKGEYLDVSFIEEEDEKIIVDKLNSTAPSGIKYFKAVKLKE GTNKKVFKSMAAVAAAKYIIQIKYKNTENLEDELKTLLNMDNWDIIKKGKKGSKNVNI KPMIKNIDYSIESNLLKINVLVSCGSIQNLSADLLAQFIKENTSDTKENSFVDIERQE IYGEYKNKLVALSDYAMYV" gene complement(4894..6744) /gene="" /locus_tag="" /db_xref="3421403..3423253" CDS complement(4894..6744) /gene="" /locus_tag="" /product="radical SAM domain protein" /translation="MNRISDDVLFRVEKPARYIGGELNSYNKDLNDIDIRYAFCFPDV YEVGMSHLGMKILYYILNERKDTFCERVFAPWPDMEKIMREENIPLYGLESKDPIKDF DFIGFTLQYEMSYTNILNMLDLAGVTIRASERGEEEPIVMCGGPCAYNPEPLYNIADM FVLGEGEELNTKILDLYKKYKGKGKKNEFLREASKIRGVYIPSLYEVTYKEDNTIKEF KPLYDDVPKKVKKVIVNSINDVVYPDKFVVPYTDIVHDRIVLETFRGCTRGCRFCQAG MIYRPVREKKTERLLELSDKLIKNTGYDEVTLSSLSICDYSDIQNLVFSMVERHKEGK VGVTLPSLRIDSFSVDLIKEIQKVRKTGLTFAPEAGSQRMRDVINKGVTEENLMTSVK SAFEAGWSTIKLYFMLGLPYETLEDVIGIAELGQKVVQKYYEVPKEVRKKGLKVTVST SIFVPKPFTPFQWAPQDTMEDVRKKIEAVRGAIKSKQITYNWHESLVSYMEALFARGD RRICDVLIKAFEKGARFDGWNQYFDFNIWKESLEECNVDGDFYAYRQREYDEILPWDF VDTGVSKEFLMRENERAKKAEVTPDCRQGCKNCGVNVNLEGECFEGAISN" gene complement(6857..7708) /gene="" /locus_tag="" /db_xref="3423366..3424217" CDS complement(6857..7708) /gene="" /locus_tag="" /product="putative metalloprotease" /translation="MVKINKYFIPYVVFLFYLGYKGSFLLSISVVFVHELIHYVTARY LGFTGFNIEIYPLGLSLKLDKLENANFKEDLLISLSAPIVNIFFAIIFCIAYGVYNNN SLYLLYKSNLIIGVFNLMPALPLDGGRILRDLLCFKTFYRRANEITINISIGISVFFM VLYIFLFMKGYNNFNLGIISLFITGFSLKEKERVAYIIMRHIVKKRCKFIKRGYIENQ NVSVHYNNTLLQTLSLIDKNKYYIFAVLDDNMKILDTLYENEILEALKNYGNIKIGEF INIKSKK" gene complement(7763..8548) /gene="" /locus_tag="" /db_xref="3424272..3425057" CDS complement(7763..8548) /gene="" /locus_tag="" /product="peptidase, family M23/M37" /translation="LYNSQYEEYYNSLKNRKNNNLRNSNYMYGERNNRRENFNSNFFQ KRIIRDLIGVFLLSVFVLSLKAFSNSQTQMVYNYSKKIVNENYDYKKVINKAKNLDVN FLEDKILRYIDTFKSKVTGEKTIEELISNDFVLPVNGKVTSTYGEREDPINKRKAFHK GIDIDAKENTEVLASFGGTVKECGEDKELGKYILLDHGQGIETKYAHLNKIKVKKGEE VKKGKDIAESGNTGKSTGAHLHFEIIYMGENKNPQDYFSNIKE" gene complement(8868..9986) /gene="rodA" /locus_tag="rodA" /db_xref="3425377..3426495" CDS complement(8868..9986) /gene="rodA" /locus_tag="rodA" /product="rod shape-determining protein RodA" /translation="MFDKFFINKKLLKELDYSMIIISVAIMIFSALNIYSATHMKYGT SFFQKQLIWLAVGLIIIYVVLIFDYIIIENYANIFYWFTIFLLVLNDTVLKKTVNGAG SWLKLGPISIQPSEFAKMALIIMLAKKLDDMEGEINNLRNFFTLAFYAVIPMILIVIQ PDMGMTMVFFFTVLGMFFVAGLDGKVISGGLAGLTALVAIIWNSPLMQQYWKNRLTSF LHPEADELNTGLQLVQSKIGIGSGGFLGKGFLKGTQIAGGYIPEAHTDFIFSVIGEEW GFIGAAILLIFYGILIYKFIKTAKNSKDIFGTMVTIGVTASFMFSILQNIGMTIGIVP ITGIALPFMSYGGSSSLNNFLALALVLNINMRRKKINF" gene complement(10085..10348) /gene="minE" /locus_tag="minE" /db_xref="3426594..3426857" CDS complement(10085..10348) /gene="minE" /locus_tag="minE" /product="cell division topological specificity factor MinE" /translation="MDLFKFFSKQSSKDVAKERLKLILIQDRNSISPDVLESIREDML KVISKYIEIDNEDVDIKMSSVEEIEGMSPALIASIPIKRIKKK" gene complement(10362..11159) /gene="minD" /locus_tag="minD" /db_xref="3426871..3427668" CDS complement(10362..11159) /gene="minD" /locus_tag="minD" /product="septum site-determining protein MinD" /translation="MGEVIVVTSGKGGVGKTTTSANISTALAAMDKKVVVIDGDTGLR NLDVLMGLENRIVFTLLDVIEERCKLKQALIRDKRLNSLYLLPTAQTRDKEDVNVDDM LKIVNDLKQEFDYVILDCPAGIERGFESSIAGADRALVVVNPEVTSVRDADRVIGKLD AKGLDNHQLIVNRLNYEMTQSGDMLDIEDIIDSLAIKLIGVVPDDRNITIATNKGEPI VLDNGAVAGQAFRNIAKRITGEEVPIMDLRSKEQGFFKSFKKLFGLK" gene complement(11177..11806) /gene="minC" /locus_tag="minC" /db_xref="3427686..3428315" CDS complement(11177..11806) /gene="minC" /locus_tag="minC" /product="septum site-determining protein MinC" /translation="LEDNIVIKGNKEGLVVIINMNKFRDFNDMINSLIQKLSHGKQFY KGSTLKISTELKLINEKNLRRLKDVLFEEFMIKDCIFEDKEDRSNKPFSGIYEGRTKF IRRTVRGGQVVRYNGNLVIIGDVNSGAEIYAAGNVIVLGALRGHVHAGFTGNHKAIVA AFYLQPSILQIANVMTRSPEDNVKPQYPEVAKIKSSIIVVEPYLPDKFI" gene complement(11981..14755) /gene="" /locus_tag="" /db_xref="3428490..3431264" CDS complement(11981..14755) /gene="" /locus_tag="" /product="penicillin-binding protein" /translation="MKINKDKKFTRFGGLMLVMVFIITAIISRLVYLQLMNSQEYKEK ANNRSIREIPDPAPRGNIIDRNGVVLATNKQNYMLIYNETAENKESFFSTMEKVFSIL DQYKEKQTDDLELKINPYRFEFKASTAEAKRAAELRFKKDRGLDDVVTKKLFSGKNKK EKEELTKEDEAKIDEELLKITPEETFKYLLEQYKIDTKKYSLEQQRRFMIVKDAAKMQ SFSGYKSVDVASNIKKETAFIFLQKLNDLPGIDVSTQPIRVYPYKEVGSAVLGYISKI SGDNEKYKEKGYDPSSDYIGIDGIEGVFEERLKGSKGGRIVKLNKTGRVIEELGRREP YPGQNIQLTIDTNIQKAAEESLDSVMKDLQQRGVQGDVNTSNATRGAAVALDVNTGEI LALASRPGFDPNLFATPGGLTPELYKQYFNPDLTEFGKQYILNKGLMGYYPGNTLDEV LEKLFPLDKSIKNNKTMRQDLYDIYPKPFYNYATMSVVPPGSTFKAMTAIAGLESGVI TPGYSISDTGVFDDGKKFVKKFAVGGYGSVDLYRGLEVSSNPYFMTVGKLLRESFGDD ILAKYAWKFGLGVPPNSDEKASTGIEIPEKFGQVFNTYTLSNVYATQYLWQTMSTLKS GTDARGNKFPSINLYDSEKDLDKVKELKKQIKNSIQDSIKEGTKKFDSNNYIKMLTEL VNQDPIYKGKNVSKDQIKRIVDVIYYVTISDAHFQLGVGANMYNAAIGQGISNFTPLQ LANFVSTIANGGDRYKLHLVKEIKDADGNVVETVKPEIVEKTNVSKENLAAVRQGMAR VNEGTDGTAAAVFKDFPIQTAGKTGSSTFSNSQDYYGRTSYGVYIGFAPVDNPKIAVC VIVFDGGHGGSVAPVAKAMYEAYFKKELNKDKPDAAKASNSGQKENTKNSDASGDDAK DIENKNTNNR" gene complement(14775..15266) /gene="mreD" /locus_tag="mreD" /db_xref="3431284..3431775" CDS complement(14775..15266) /gene="mreD" /locus_tag="mreD" /product="rod shape-determining protein MreD" /translation="MKKKLILGAILILLAILDNSLMPFVAIKGVYPSLLFVFILSYSI IKDKWEAIWIGIFAGMLQDLYFANIFGINSLINMFVCLIASEIGVNIIKSKILIPVIS SFALSIFKGVFIWVIAYFLKINISYSLIAFNSIYNGVITIIVYKLVYNLCRKKYMDKK WEF" gene complement(15277..16134) /gene="mreC" /locus_tag="mreC" /db_xref="3431786..3432643" CDS complement(15277..16134) /gene="mreC" /locus_tag="mreC" /product="rod shape-determining protein MreC" /translation="MKFFKNKLTVTIIVLSVTFLVLITQSAERSKISFVESGIGTVVN PVQGVFYRVNKKIRNSIGFVLNIPDVKKENVELKSKNSKLESQLVEYKSLKDENERLR KMLNFKNQHSEFNYVGADIIGKSGGNYLDEFTINKGSNDGVFKGMIAITNEGLVGQVI ATGGSWAKVQSLSNENLAVSAMVDSTKENSGVVKGFKDSQNNILAKLYFLPIDSKIKE KDIILTSGLGAMYPKGIRIGEVKSIEVDKGKVMKNAIIKPYVDLRKIEEVFIVIPKVM PNNKEEVKY" gene complement(16141..17151) /gene="" /locus_tag="" /db_xref="3432650..3433660" CDS complement(16141..17151) /gene="" /locus_tag="" /product="rod shape-determining protein MreB" /translation="MRLFGITKDMGIDLGTANTLVYIKGKGVVLSEPSVVAINKDVNK VLAVGDEAKQMIGRTPGNIVAIRPLKDGVIADFDVTQIMLKKFIEKVSPKGGFTNPRI VVCFPSGVTEVEKRAIDEATKSAGAREVVLMEEPMAAAIGAGLPVNEPTGSMIVDIGG GTTEVAIISLGGIVTSKSLRVAGDELDQSIINYIKKEYSLMIGERTAENIKVELGSAY KTDEDKTMEIRGRDLITGLPKVITISQKEVREALSEPVISIIEAIKTTLEKTPPELAA DIMDKGIMLAGGGALLRGLDQLINEETHMPVHIAESPLDCVAVGAGKALDTIDKILDS KK" gene complement(17180..17866) /gene="" /locus_tag="" /db_xref="3433689..3434375" CDS complement(17180..17866) /gene="" /locus_tag="" /product="DNA repair protein, RadC family" /translation="MDNNFKIKDLPKNERPQERLIRYGAEVLSNSELLAVILRTGTKN QNIMMLASSLIKETGGLDQLFNQSIEELTKIKGIGVTKAVQILALSELSKRFKTYKSG NEYKINTPLDVSNLVMEDMKYLKQEKLKILILNTKNIVTYIRDVFIGTLNSSIVHPRE IFCEAIKKNGASIIICHNHPSGDPTPSKEDINITLRLKECGKLIGIDLLDHIIIGENK YVSMKEKGTI" gene complement(17881..18465) /gene="maf" /locus_tag="maf" /db_xref="3434390..3434974" CDS complement(17881..18465) /gene="maf" /locus_tag="maf" /product="septum formation protein Maf" /translation="VKNIILASASERRQELLKRILEDFQIIVSDFDESSIPFKDNISS YVMNLAEGKARSVSKKIMDQDNNLVIGCDTLVAFNNKILGKPKDKKDAFEMLQALSGN EHEVYSGLAILDVKSNKIITDFVCTKVKFSKLTSLQIEKYVNTGDPMDKAGAYGIQGK AGVFVENINGCYYNVVGLPLNKLNSMLMEMGVNL" gene complement(18481..18738) /gene="" /locus_tag="" /db_xref="3434990..3435247" CDS complement(18481..18738) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKSPDKNKSLLGVFILLGAILGSIAGEILGSSFTKLSFLKTAYK VGTTSPLNLDLKVLNLAIGLNFDINIMTIMGIVLAIILYRK" ORIGIN 1 ttataataaa aagtcaaatt caaagtcatt taatcgtaca acatcaccat cttcaatacc 61 catttccatt aattcttcca ttaccccttt atttttaagt actttatgga aatatcttaa 121 atcatctgga tcatttacat taactgcatt caaaagtcta tctacaaaac ttccttccac 181 aatataagtg ttatcttctt ttcttataga gtatgtaaat ctcttttctt cctctataaa 241 tctatcttct tctgatattt ctagatctgt aacaggtata gtacttaaaa gtcttgcagc 301 ttctttcata agatcatcta caccttgctt tgtagctgct gatatcttaa acaccttatt 361 ataaccatgt ttttctactt ttgttttaaa ttcttcaaac ttttcttcat caaataacat 421 atcagattta ttagcagcta ttatttgagg tctatcataa agttttacac tatatctttt 481 tagttcgtcg tttatcttta aaaaatcatc ataagggtct cttccttcta cagaagatat 541 atctattaca tgaattaata ctcttgttct ctctacatgt cttaaaaaat ctaaacctaa 601 tcctactcct tctgaagcac cttcaattat tcctggtata tctgcaatta caaaattatt 661 tacaccttca atacttacca cgcctaaatt aggttttaat gtagtaaaat gatagttagc 721 tattttaggt ctagctttag atacgactga taataaagta gattttccca cgttaggaaa 781 tcctataagg cccacgtctg ctaaaagttt taattcaagc ttaatccatc tttcttcctc 841 tggcatacct ggttctgcaa aatctggtgc ctgtcttgta ggtgttgtaa atctgcaatt 901 acctttacca cctcttccac ctttagcaac cacataagag tcctctggtt ttgataaatc 961 tgccattatt ttgtctgttt ctgcatcttt aactatagtt cccataggta cttttatatg 1021 tagatcttta ccgtttttac caaaacattt tgatcctgcg ccatttccac ctggttccgc 1081 tttatatttt cttttataag taaaatctaa tagagttgtc atattaggat ctactactag 1141 tactacatta ccgcctttac cgccatctcc accatctggt cctccaaaag ctatatattt 1201 ttctcttcta aaagagatgg atccatctcc tccttttcct gattttacaa atattttggc 1261 tgtatctata aacaaagttt ttcactcctc tttacttcga taattaatat ataatattgc 1321 ttataaaatt tagctatact aatttaaatg tatagtcaat tgtgttaatt ttataatttt 1381 ttatcatatt atttatcaaa aaattttata tttatattaa cataaatgtt gttttcttaa 1441 tttaaaatca attattatta tatcttattt tatgcatata aatattattt tataaaatat 1501 ttatatattt ttaatgattt atataattat tttttaatat tttatttctt aactatggaa 1561 ggtaaagtgt gtattataat agtgaacctt tccctaaata aaaaattatt taattgaatc 1621 ctaaaaaagc acccttataa agggtgcttt taattattca gctactactt cttcaacttc 1681 tactggatat acactagctt ttttcttatc tcttccaagt ctttcgtatt ttactacacc 1741 gtcgatttta gcgaataatg tatcatctcc acctcttcca acgtttagac ctggatggat 1801 ttttgttcct ctttgtctaa ctaatatgtt tccagctaaa acgaattgtc cgtcagagca 1861 ttttactcct aatcttttag cttcactatc tcttccgttc tttgaactac ctaccccttt 1921 tttatgagca aatagttgaa ggttcattac taacatgact acacctcctc cattgtaagt 1981 tttatatatt cactgtaatt aaattctata ctttttaatc ctaacaacat agtactcata 2041 agcacttggc atttatgtat gtcttcttta atacaagatc ttaaatctat acttaaaaag 2101 ccatcttcct cttttattaa aggattaatc tttaatactt ctgttatacc attagctatt 2161 gtaattgata cagcagatat agcagaacat accatgtcat acccctggtc tgtagacccc 2221 gcatgaccac tcattttaac aaatactata tcattatttt cttttttaaa tactacatta 2281 accataatta tgcgttaatt ttttctattt ggatttttgt atatggttgt ctgtgacctt 2341 gtttctttct gtagtctttt tttggtttgt atttaaatac aacaactttt ttagcttttc 2401 cttgtgctaa tactttagct gtaactttag caccttctac cattggtttt ccaacaactg 2461 tttcttcgtt gtcttttcct actaaaagaa cattgtctaa ttctactgtt gaatcaacat 2521 cagctgttaa tttttcaacg aatagtacat ctccttcagc aactttatat tgctttcctc 2581 cagtaactac aactgcgtac attaaaaaca cctcctcatt ccagtctcgc caattaaggt 2641 acatgcaaat catgtttaac accttttctg agcggtctac aaaagccatt ttaccatagc 2701 ggacttactt tgtaaagaaa ttttattaat aaatcttaag gtcttttaca tcttctattt 2761 gatttttaaa tattaatggt tctaccttat actgattttc agcatctata taatttatat 2821 aaatattttt ttctaaagct tcaatttctg atatgaattg tattctattt ttatctatat 2881 aatctttata tcttttattt agttctatat atatatcctt tatctctctc atattcaaaa 2941 tatttattat ttcatttcta attaataact tcatataagt aaaactaact atagatcctt 3001 ttccactaca acatttacaa ggctgttcta tataatcata tattgttttg ccctgtcttt 3061 ttctagctat ttgaaccaaa tttaattctg taaagggata aacaacagat ttatttttat 3121 ctctttttag tccctgcttt aatttatcta agactttttc tttaagattt tcattatcca 3181 tatctataaa atctattaca ataatcccat ttaaatttct aagtataatt tgattacaaa 3241 tttcatccgc agcctccata ttagtagtaa aaatagtttt ctccatggaa ttacccttca 3301 catttttacc agagttaacg tccactacat acattgcttc agttttatct attataatat 3361 agcctccaca atttaaataa acttttttat ttctaagaga aagtatttct ttttctatag 3421 cataataatc taaaagattc ctttctcctt cataaatatc tagttttata ttgttttctc 3481 cgtattcttt tagaaactca cttacataaa catagtcttc tctacaattt aaataaattt 3541 ttgatatatt atcgtttaat ttatctctta gtattttgcc tactattcct ccgttttgaa 3601 atagaactcc tgtattcatt ttatatttag atttttctat cagagaacta tatattttat 3661 ataatcttct tatctcatta tttatatttt ctatacttgt atttatagct tccgttctta 3721 ttagaatccc tacatcttta ggctttacta tattattttg tatttctgtt cttatttttt 3781 catcttttat tttatgagaa aatgtaattt cattgtttaa aatttgaaga actgtatacc 3841 tgcccggtat agttatagca ttagttactt tagggccttt tttatttaag tcctctttaa 3901 ctacttctac taaaatatag tctccttttt ttatatgggt attattgaac tttttatcta 3961 aataaagata tgcattctta ttccaaccta tatctacaaa agcgcttttt atagcaggaa 4021 ttatattttt aaccatacct acataaatct ctccaacctg aggagattta ttatcttctt 4081 ctataaataa ttcttttatg tgattacttt ctcttaaaac tattcttaca ttttctcttt 4141 gcctttctat aaatatttct ttcactctaa aggcacttcc cttctttaaa taaagaaaat 4201 aatttataca tacatagcgt aatcagaaag agctactaat ttatttttgt attctccata 4261 tatttcttgt ctttctatat ctacaaaact attttctttt gtgtcagatg tattttcctt 4321 tataaattgg gctaaaagat ctgcagaaag attttgaata cttccacaac ttactaaaac 4381 atttattttt aataaattac tttctataga ataatctata tttttaatca taggttttat 4441 atttacattt ttgcttccct ttttgccttt tttgattata tcccaattat ccatatttaa 4501 taatgttttt aactcatctt ctaaattttc cgtattttta tattttattt gtattatata 4561 ttttgctgct gctactgctg ccatagactt gaatactttt ttatttgtac cctcttttaa 4621 ttttacagct ttaaaatatt ttatacctga aggagcagta ctatttaatt tatctacaat 4681 tattttctca tcttcttcct ctataaaaga tacatctaaa tactctcctt tagagtaaag 4741 tcctactgct aaaggttgag ctaaagacat aattatatga ggattaaaac cttttgaata 4801 ctctacaggt aatccacttc ttttaaaatt tctttgtaga gttctttgaa ggtctaaatg 4861 agatacaaat tttatattac cttcctttga aaatttaatt agatatcgca ccttcaaaac 4921 actctccttc taaattaaca tttactccgc aattcttaca gccctgtcta caatctggag 4981 ttacttctgc ctttttagct ctttcatttt ctctcattaa gaactccttt gaaactcctg 5041 tatctacaaa atcccaagga agtatttcat catattctct ttgtctataa gcataaaaat 5101 ctccatctac attgcattct tccaaggatt ctttccatat attaaagtca aaatattgat 5161 tccatccatc aaatctagca cctttttcaa aagcttttat taaaacatca caaattcttc 5221 tatctcctct tgcaaataga gcttccatat aacttactaa ggattcatgc cagttataag 5281 ttatttgttt actttttata gctcctctta cagcctctat tttctttctt acatcttcca 5341 tggtatcctg tggtgcccat tgaaatggcg taaatggctt tggtacgaaa atagacgtac 5401 ttacagtaac cttaagtccc ttctttctta cttcctttgg aacttcataa tatttttgta 5461 caaccttttg tcccaactct gctattccta taacatcttc taatgtttca taaggcaatc 5521 ctagcataaa gtataatttt atagtagacc aacctgcttc aaaagcactt tttactgagg 5581 tcattaaatt ttcttctgtt acacctttat ttataacatc tctcatcctt tgacttcctg 5641 cctctggtgc aaaagtaagt ccggtttttc taaccttttg tatttctttt attaaatcta 5701 ctgaaaaaga atctattctt aatgaaggta atgttactcc tactttaccc tctttatgtc 5761 tttctaccat tgagaataca agattttgta tatcagaata atcacatata cttaaagaag 5821 atagtgttac ttcatcatat cctgtatttt ttattaattt atcagataat tctaataacc 5881 tttctgtttt cttttctctt acaggtctat atatcattcc agcttgacaa aatctacagc 5941 ctcttgtaca tcctctaaaa gtttctaaaa ctattctatc atgaactata tcagtataag 6001 gaacaacaaa cttatctgga taaactacat cgtttatact attaacaata acttttttta 6061 cttttttagg cacatcatca tatagaggtt taaattcttt tatagtatta tcttctttat 6121 aggtaacttc atagagagaa ggtatataca cccctcttat tttagatgct tctctcaaaa 6181 attcattttt ctttcctttg cctttatatt ttttatataa atctaatatc ttagtattta 6241 attcttcccc ttctcctaga acaaacatat ctgctatgtt ataaagtggt tctgggttat 6301 atgcacaagg tcctccgcac attactatag gttcctcttc ccctctttcc gaagccctta 6361 tagtaactcc agctagatct aacatattta atatattagt gtaactcatc tcatattgca 6421 gagtaaatcc tataaaatca aaatccttta tgggatcttt gctttccaaa ccatatagcg 6481 gaatattttc ttccctcatt attttctcca tatctggcca aggtgcaaaa actctttcac 6541 agaaagtatc ttttctctca tttaatatgt aataaagtat tttcatacct aaatgagaca 6601 ttccaacttc ataaacatct ggaaaacaaa atgcatatct tatgtctata tcatttaaat 6661 ctttattata agaatttaat tctcctccta tatatctggc aggtttttct actctgaata 6721 gtacatcatc tgatattctg ttcatcaaat ttcctcctca tggtttatca cattattaca 6781 ttttaacaca taagcatgga taaaaacaat tacaaaagaa tccattgtcc tatccatgct 6841 tataaaagct tccttattta ttttttactt tttatattaa taaattcacc tatttttata 6901 ttaccatagt tttttaaagc ttctaatatt tcattttcat ataaagtatc taatattttc 6961 atattatcgt ctagcactgc aaatatataa tatttatttt tatctataag tgaaagtgtt 7021 tgtaataaag tattattata atgaacagac acattttgat tttcaatgta tcccctcttt 7081 ataaatttac atcgcttttt gactatatgc ctcataataa tataagctac cctttccttt 7141 tcctttaatg aaaatcctgt tataaataag gatattatac ctaaattaaa attattataa 7201 cccttcataa ataaaaaaat atataatacc ataaaaaaaa cacttatacc aatactaatg 7261 tttatagtga tctcatttgc ccttctataa aaagttttaa aacataataa atctcttagt 7321 attcttccac catctagtgg aagagctggc ataagattaa aaacacctat tatcaaatta 7381 cttttatata ataagtataa actgttatta ttatatactc cataagctat acaaaaaatt 7441 attgcaaaaa aaatattaac tattggtgca gataatgata ttaataaatc ttccttaaaa 7501 ttagcatttt ctagtttatc taattttaag gataatccta aaggataaat ttctatatta 7561 aatcctgtaa atcctaaata tctggctgtt acataatgaa ttagctcatg gacaaaaaca 7621 acagaaattg ataatagaaa acttccttta tatcctaaat aaaataagaa taccacatag 7681 ggaataaaat atttatttat ttttaccatg tttgcctctt aagaattgct tacatctact 7741 acaatattca ctatacatta cttttattct tttatatttg aaaaataatc ttgtggattt 7801 ttattctctc ccatataaat tatttcaaaa tgaagatggg ctcctgtact cttccctgta 7861 ttaccacttt cagctatatc ttttcctttt ttcacttctt cccctttctt tacctttatt 7921 ttatttaaat gagcatattt agtttctatg ccttgtccat gatctaagag tatatattta 7981 cctaactctt tatcttctcc acattccttt actgtgccac caaaacttgc tagtacttct 8041 gtgttttctt tagcatctat atctatccct ttatgaaaag cttttctctt atttatagga 8101 tcttctcttt ctccgtaggt ggaagttact ttgccattta caggtagtac aaaatcatta 8161 cttattaatt cttctatagt cttttctcct gtaaccttcg atttaaaagt gtctatatat 8221 cttaaaattt tatcttctaa aaaatttaca tctaagtttt tagccttatt aattactttt 8281 ttataatcat aattttcatt aactattttt ttagagtaat tatacaccat ctgagtttgg 8341 gaattagaaa aagcttttaa acttaaaaca aataccgata ataaaaatac ccctattaga 8401 tctctaataa tacgtttctg aaaaaaatta ctattaaaat tttctcttct attatttctt 8461 tctccataca tataattact atttcttaaa ttattatttt ttctattttt taatgaatta 8521 taatattctt catattgaga attatacaat ctaaccactc ctacaatact tttatattct 8581 tatttatatt ggatttttta tctatttatt acttaaaaaa ttttctataa ataacaaagt 8641 catatattgt taaaaatcct aagtttttaa acagaatttt taacagtata tgacttttaa 8701 ttcttaagga gattaatatt tatatcgttc atattgcttt aaaataatca agttactatt 8761 aaaatttaaa atattatagt gtatacataa atatatttta aaagctcatt ataaagcaaa 8821 aacctattta gtactaattt ttatttgact aaataggttc atatactttt aaaaatttat 8881 tttttttctt ctcatattta tatttaatac taatgctaaa gctaaaaaat tatttaatga 8941 cgaacttcct ccataactca taaatggaag tgctatacct gttataggta ctatgcctat 9001 agtcattcca atattttgaa gtattgaaaa cataaaagaa gctgttacac caatggttac 9061 catagttcca aatatatctt tagaattttt tgcagttttt ataaatttat atattaaaat 9121 cccataaaat attaacaaaa ttgcagctcc tataaaaccc cattcttcac ctataacaga 9181 aaaaataaaa tctgtatgag cttctggaat atatccacct gctatttgtg ttccttttaa 9241 aaatcccttt cctaaaaaac cgccagaccc tatacctatt ttcgattgca caagttgaag 9301 tcccgtattt aattcatctg cttcaggatg taaaaatgaa gtaagcctat ttttccaata 9361 ttgttgcatt aaaggagaat tccaaataat agctactagt gcagttagcc cagcgagccc 9421 tcctgatatt acttttccgt ctaatcccgc tacaaaaaac atacctaaca cagtgaaaaa 9481 aaacaccata gtcataccca tatctggctg aattacaatt aatatcatag gtattacagc 9541 ataaaaagct aaggtaaaaa aattccttaa gttgtttatt tccccttcca tatcatctaa 9601 tttcttagct aacattataa ttaaagccat tttagcaaac tctgaaggtt gtatggatat 9661 aggtcctaac ttcagccaag aacctgcacc attaactgtt tttttaagaa ccgtatcatt 9721 taaaacaagt aaaaatatag taaaccaata aaatatattg gcataatttt caataataat 9781 ataatcaaat attagaacca cataaattat aataaggcct acagctaacc aaattaattg 9841 tttttggaaa aagcttgtac catatttcat atgggtagca ctatatatat ttaaagcact 9901 aaaaatcatt attgctacag aaattataat catactataa tctaactctt ttagaagttt 9961 tttatttata aaaaatttat caaacatctt atcacccctt aattacaaat atgattatac 10021 catatcacac acaaaaagct atgtacaaat ttatacatag ctaaaaaaat ttcttaattt 10081 tttatttatt ttttctttat tctctttatt ggaatactag ctattaatgc tggagacatg 10141 ccttctattt cttctacact actcatcttt atatctacat cttcattatc tatttctatg 10201 tatttagata ttacctttag catatcttct cttatagatt ctaaaacatc cggagatata 10261 gagttcctat cttgtattaa tataagttta agtctttcct tggctacatc ttttgatgat 10321 tgttttgaaa aaaacttaaa taaatccatt accttatcac tcctacttta acccaaataa 10381 ttttttaaag gatttaaaaa agccctgttc cttacttctt aaatccatta taggtacttc 10441 ttctccagta atcctttttg caatgtttct aaatgcctgt ccagctacag ctccattatc 10501 taaaactata ggttctcctt tatttgtagc tatagttata tttctatcgt ctggcactac 10561 ccctataagc tttatagcta aactatcaat tatatcttca atatctaaca tatctccgct 10621 ttgtgtcatt tcataattta atctatttac tataagctga tgattatcta ggcctttagc 10681 atctaatttc cctataactc tatctgcatc tcttacagat gttacttctg gatttacaac 10741 tactaaagct ctatctgctc ctgctataga gctttcaaat cctctttcta tgcctgctgg 10801 acaatccaaa atcacataat caaattcctg ctttaaatca ttgactattt taagcatgtc 10861 atccacatta acatcttctt tatctcttgt ttgtgctgtt ggtaatagat ataagctatt 10921 taatctttta tcccttatta atgcttgttt taacttacat ctttcttcta ttacatctaa 10981 tagggtaaat actattctat tttcaagccc cattaaaaca tcaaggtttc ttaatcccgt 11041 atctccatct ataacaacta cttttttatc cattgcagct aaagctgtag atatattagc 11101 tgatgtggtt gtttttccta ctccaccttt accagaggta acaactatca cttctcccat 11161 tttttgtcct ccttaattta tataaatttg tccggtagat atggttctac tactattatg 11221 cttgatttaa tctttgcaac ttctggatat tggggtttta cattatcttc tggtgatcta 11281 gtcataacat ttgctatttg aagtatggaa ggttgtaaat aaaatgctgc cactatagcc 11341 ttatgatttc ctgtaaatcc agcatgaaca tgtcccctta aagctcctaa aactatcaca 11401 tttcccgccg catatatttc tgcaccagaa ttaacatccc caattataac taaatttcca 11461 ttatatcgta ctacttgtcc tcctcttaca gttcttctta taaattttgt tcttccttca 11521 tatatgccac taaagggttt attggatcta tcttccttat cctcaaatat acaatctttt 11581 atcataaact cttcaaaaag aacatctttg agccttctta agtttttttc gtttatgagt 11641 tttaattctg tagatatttt taatgtagat cccttataaa attgttttcc atgagataat 11701 ttttgtatta acgaattaat catatcgtta aaatctctaa atttattcat attaattatt 11761 acaacaagac cttctttgtt accttttatt actatattgt cttccaaaat aaaaacctcc 11821 aaagtagcta taaaaaacac tatcttaatt tatatttcca cattttttta ttaattcctt 11881 ctgtttatta tacttttatt tatttaatat tttccatttt aaaatatcca cactatctat 11941 tatataaaat aatttatagt gtggatatag tttatattta tttatctgtt atttgtattt 12001 ttattttcta tgtcctttgc atcatctccg ctagcatctg aattcttagt attttccttt 12061 tgccctgaat ttgatgcttt agctgcatct ggtttgtctt tattaagttc cttcttaaaa 12121 taggcttcat acatagcctt tgctacaggt gcaacagatc ctccatgtcc accatcaaat 12181 acaataacac atactgctat ttttggatta tcaactggag caaatcctat ataaacacca 12241 taagatgttc ttccataata atcttgacta ttactaaaag tagaagatcc tgttttacct 12301 gctgtttgta tagggaaatc cttaaacact gctgctgcag taccatctgt tccctcatta 12361 actcgtgcca ttccttgcct tacagcagct aaattctctt tgcttacatt agtcttttca 12421 actatctctg gtttaactgt ttctactaca ttaccatctg catcttttat ttctttcacc 12481 aaatgcaatt tatatctatc tcctccatta gctatagtac taacaaaatt agccaattgt 12541 aatggagtaa agttacttat accttgtcct atagcagcat tgtacatatt agcacctaca 12601 cctaactgga agtgagcatc tgatattgtt acatagtata taacatctac aattcttttt 12661 atttgatctt tacttacatt tttaccttta tagataggat cttgattaac taactctgta 12721 agcattttta tataattatt agaatcaaac tttttagttc cttcttttat agagtcctgt 12781 atagaatttt taatttgttt ctttaattcc ttaaccttgt ctaaatcttt ttcgctatca 12841 tataaattta tagatggaaa tttatttccc ctagcatctg ttcctgattt taaagtagac 12901 atagtttgcc acaagtattg agttgcataa acattagata atgtataagt attaaatact 12961 tgtccaaact tttcaggaat ttctattcct gtagaagctt tttcatctga atttggtgga 13021 acacctaacc caaatttcca agcgtatttt gcaagtatat catcaccaaa actctctctt 13081 aataatttac ctactgtcat aaaataaggg ttactagaaa cctctaatcc tctatataaa 13141 tcaacggaac catagccacc tactgcgaat ttctttacaa acttctttcc gtcatcaaaa 13201 acgcccgtat cgcttataga atatccagga gttataaccc ctgattctaa tcctgcaata 13261 gctgtcatag ctttaaatgt agatcctgga ggtactacag acatagtagc ataattataa 13321 aaaggctttg gatatatatc atataaatct tgcctcatag ttttattatt ttttatactt 13381 ttatctaaag gaaatagctt ttctaaaacc tcgtctaaag tatttcccgg ataatagccc 13441 attaatcctt tattaagtat atattgtttt ccaaactcag ttaaatccgg gttaaaatat 13501 tgtttatata gttctggggt taatcctcct ggagttgcaa ataagttagg atcaaagcct 13561 ggcctacttg ccaaagctaa aatttctcct gtatttacat ctaatgctac tgcagcacct 13621 cttgtagcat tagatgtatt aacatcgcct tgtactcctc tttgttgaag atctttcatt 13681 acagaatcca gcgactcttc tgcagccttc tgtatattcg tatctatagt aagttgtata 13741 ttttgacctg gataaggttc tcttcttcct aattcttcta taacccttcc tgttttatta 13801 agtttaacaa ttcttccacc tttagatccc ttaagtcttt cttcaaaaac accctctatt 13861 ccatctatac ctatataatc agaacttggg tcatatccct tttctttata tttctcatta 13921 tcaccactta ttttagatat atagcctagt actgctgatc ctacttcctt ataaggataa 13981 actcttatgg gttgagtgct tacatctata cctggtaaat catttaattt ctgaagaaat 14041 ataaaagctg tttctttctt tatattactt gccacatcaa cagatttata tcctgaaaag 14101 ctctgcattt ttgctgcatc ttttactatc ataaatcttc tttgctgttc tagagaatat 14161 ttctttgtat ctattttata ttgttctaat aaatatttaa aggtttcctc tggagttatt 14221 tttaataact cctcatctat tttagcttca tcttcttttg ttaattcttc tttttctttt 14281 ttgtttttac ctgaaaataa tttttttgta actacatcat ctaatcctct atctttttta 14341 aatcttaact ctgctgctct ttttgcctca gctgtactag ctttgaattc aaatctataa 14401 ggattaattt taagctcaag atcatccgtt tgtttttctt tatattgatc taatatgcta 14461 aatacttttt ccatagtaga aaaaaaactt tctttatttt ctgctgtttc attatatata 14521 agcatgtaat tttgcttatt agtggctaat actactccat ttctatctat tatattccct 14581 cttggagcag gatctggaat ttctcttatg gatctattat ttgctttttc tttgtactcc 14641 tgtgaattca taagttgcaa ataaacaagt ctagatataa ttgcggtaat tataaatacc 14701 attaccaaca taagaccacc aaatctagta aattttttat ctttgtttat cttcattgac 14761 taaatcacca ttcctttaga attcccactt tttatccata tatttttttc tacataaatt 14821 atacactaat ttataaacta taattgttat taccccatta tatatactat taaaagctat 14881 taaactataa cttatattaa tctttaaaaa ataagctata acccatatga aaactccttt 14941 aaatatgctt agtgcaaaag aagatatcac tggtattaat attttacttt ttattatatt 15001 tacacctatt tcggatgcta ttaagcaaac aaacatattt attaaggaat ttatcccaaa 15061 tatattagca aagtataaat cttgaagcat acctgcaaaa ataccaatcc aaatagcctc 15121 ccatttatcc tttattatag agtagcttaa tataaaaacg aataaaagac taggatatac 15181 accttttatt gctacaaaag gcatcaaaga attatccaat atggcaagta atattaaaat 15241 agctcctaat attaattttt ttttcatatg catcacctta atattttact tcttctttat 15301 tgttaggcat tactttaggt attactataa atacttcttc tatttttctt aaatctacat 15361 aaggtttgat tatagcattt ttcattactt tacccttatc tacttctata ctctttactt 15421 ctcctattct tatgccctta ggatacattg ctccaagacc agaagttaaa ataatatctt 15481 tttcttttat tttagaatct attggtaaaa aatataattt tgctaaaata ttattttggc 15541 tatctttaaa tccttttaca acaccactat tttctttagt actatctacc atagcactaa 15601 cagctaaatt ttcattagat aaagattgaa ctttagccca acttccccct gtagctatta 15661 cttgtcctac taaaccttcg tttgttattg caatcatacc tttaaatacc ccatcattag 15721 accctttatt tattgtaaac tcatctaaat agttaccacc acttttacca attatatctg 15781 caccaacata gttaaattcc gaatgctgat ttttaaaatt aagcattttt ctcaatcttt 15841 cattttcatc ctttaaagac ttatattcta ccaactgact ttcaagctta ctatttttag 15901 attttaattc tacattttct ttttttacat ctggtatgtt aagaacaaaa ccaatagaat 15961 ttctaatttt tttgtttact ctataaaaaa ctccttgaac tggattaact acagtcccta 16021 tgccactttc cacaaaagat atcttgcttc tctccgcact ttgtgttatt aatactaaaa 16081 aggtaactga cagtacaatt atagttactg tcagtttatt tttaaagaac ttcatagtct 16141 attatttttt actatctaat attttatcta tagtatctag tgctttacca gcaccgacag 16201 ctacacaatc aagtggagat tcagcaatat gaacaggcat atgagtttct tcgtttataa 16261 gttggtctaa tcctctaagc agagcaccgc ctcctgctaa cattattcct ttgtccatta 16321 tatcagctgc aagttctggt ggagtttttt ctaatgtagt ttttatagct tctattattg 16381 aaataactgg ttcacttaaa gcttctctaa cttctttttg agaaatagtt ataacttttg 16441 gtaagcctgt aatcaaatct ctacctctta tttccattgt tttatcctca tcagttttat 16501 aagctgaacc taattctact tttatatttt cagctgttct ttcaccaatc atcaagctat 16561 attctttctt tatgtagttt attatagact gatctaattc gtctccagcc actcttaagg 16621 atttacttgt tactatacct cctaatgata taatagcaac ctctgtagtt cctccaccta 16681 tatctactat catacttcct gtaggttcat taactggaag tcccgctccg atagctgctg 16741 ccattggttc ttccataaga accacttctc ttgctccagc tgactttgtt gcttcatcaa 16801 tagctctttt ttctacttct gtaactcctg atgggaaaca gactactatt cttggattag 16861 taaatcctcc ctttgggctt actttttcta taaatttttt aagcattatt tgagtaacgt 16921 caaaatctgc tattactcca tcttttaatg gtctaatagc cactatattt cctggggttc 16981 tacctatcat ttgttttgct tcatcaccta cggcaagaac cttatttaca tctttattta 17041 tagccacaac agagggttcg cttaaaacaa ccccctttcc cttaatatat actaatgtat 17101 ttgctgtacc taaatctatt cccatatctt tagttatacc aaacaatctc ataaaagttt 17161 tactcctctc tattccttag ttatattgta cctttttctt tcatacttac atacttattt 17221 tcaccaatta ttatatgatc taataaatct attcctatta atttaccaca ttcttttaat 17281 ctcaaagtta tatttatatc ttctttgcta ggggttggat cccctgatgg atgattatga 17341 catataatta tggatgcacc atttttcttt atagcttcac agaatatttc tcttggatgt 17401 actatagatg aattaagagt tcctataaaa acatctctta tatatgtaac tatattttta 17461 gtatttaaaa ttaatatttt taatttttct tgttttaaat acttcatatc ttccataact 17521 aaattagata catctaaagg tgtatttatc ttatattcat tgccagattt ataagtttta 17581 aacctcttag aaagctctga taatgctaat atttgaactg cttttgttac acctattcct 17641 ttaattttag ttaactcttc tatagattga ttaaaaagtt gatccaagcc accagtttct 17701 ttaattaaac tacttgcaag catcattata ttttgatttt tagtaccagt ccttaaaata 17761 acagctaaaa gttctgaatt tgaaagaact tctgctccat atcttataag tctttcctgt 17821 ggtctttcat ttttaggtaa atcctttatt ttaaagttat tgtccattta tacaactcct 17881 tttaaagatt tacccccatc tccattaaca tagaatttaa tttatttaaa ggtaacccta 17941 caacattata atagcatcca ttgatgtttt caacaaaaac tcctgccttt ccttgaatac 18001 catatgcacc tgctttatcc ataggatccc ccgtatttac atatttttct atttgtaatg 18061 aagttagttt tgaaaattta actttagtac aaacaaaatc cgttattatt ttattagatt 18121 taacatctaa tatggctaat ccagaataaa cttcatgctc attaccactt aaagcctgca 18181 acatttcaaa ggcatctttt ttatctttag gtttacctaa tattttattg ttaaaagcta 18241 ctagtgtatc gcatcctatt actagattgt tatcctggtc cattattttt ttactaacag 18301 atctagcctt cccttctgct aaattcatta cgtaagacga tatgttatct ttaaaaggta 18361 tgctactttc atcaaaatca cttactataa tctgaaaatc ttccaatatt ctttttaaaa 18421 gctcttgtcg tctttcagat gcagaagcta atataatatt tttcactgat atcacttcct 18481 attatttcct gtataatatt attgccaata ctatacccat tatagtcata atattaatat 18541 caaaatttaa acctatagct aaatttaaaa cttttaggtc taaattcagt ggcgaagtag 18601 ttcctacttt atatgcggtt tttaaaaagg ataacttagt aaagctagaa cctaatattt 18661 caccagcaat gctacctaaa atagccccta atagtataaa aactcctaat aaacttttat 18721 ttttatctgg acttttcat //