LOCUS NC_012563:10 18640 bp DNA linear BCT 26-AUG-2011 DEFINITION Clostridium botulinum A2 str. Kyoto, complete genome. ACCESSION NC_012563 SOURCE Clostridium botulinum A2 str. Kyoto, complete genome. COMMENT locus start: 2101449; locus end: 2120088 FEATURES Location/Qualifiers source 1..18640 /organism="Clostridium botulinum A2 str. Kyoto, complete genome." gene complement(0..578) /gene="" /locus_tag="" /db_xref="2101449..2102027" CDS complement(0..578) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKFNGWNSFEDLARACGYTNSHKDSDNTSETSNNNATNESCNMG CYDIPNGFQSLNPQLFVAIGGILGDILAGSIPANVQAALGNWLLLVGQAIVTFNAQQI YFQQGPGRYFNPQNYNVDNPFCQTTSQNTTQNNSSSKNSKNSSKSKEKNSNSDYNKKS SSKNKVDKIEELELRINQLISEVERIKNEIEK" gene complement(1257..1844) /gene="" /locus_tag="" /db_xref="2102706..2103293" CDS complement(1257..1844) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKKNFKLIIGGLIIFIAGYFIGDATAISRVNKQIGQSVDKQVSS TKEEVKEEKKDVKFGEQSPVGNLSIKILEAKENGAISNESGKSTPSGKFIVIKLDIKN NGEEATGYEPHEFKLNDGKKTYGVDDNSFEALGHLNSQESIFRENKNFIGSYDKINAG INKNTFLVFDIPKDIKIDNLKLITEHNKGIQFNLK" gene complement(1973..2731) /gene="" /locus_tag="" /db_xref="2103422..2104180" CDS complement(1973..2731) /gene="" /locus_tag="" /product="N-acetylmuramoyl-L-alanine amidase" /translation="MKIEIDCGHTLSGADYGAVGIKAESNLTREVGTKVISKLQALGH TVIKCYKDTCSSLQDSLSYRTNMANNYNVDLYVSIHFNAFNGSAYGTEVLTYGGKSFT EASRVLNNICTLGYTNRGIKDGSNLYVLKHTKAKAMLIECCFCDNRNDMSRYNAENMA NAIVKGLVEKTTNNSIPSQPSTNNGWVNLDGKTGTICTPSGVNVREKKSTSSRILGTL PNGAKVRLYRKEGDWIHIYYPSHGGYIYGKYVKY" gene complement(2731..2904) /gene="" /locus_tag="" /db_xref="2104180..2104353" CDS complement(2731..2904) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MNRALRKITSARWLIAVMMTIVFAILAIRNTLNTEFLTIYTMII AFYFSKDRKEVGN" gene complement(2906..3130) /gene="" /locus_tag="" /db_xref="2104355..2104579" CDS complement(2906..3130) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MEQEMMKYMISQGAFAVLFCYLLYFVLKTSKEREEKMQSTIDKN QEVIGDLARKFDVLEDVKRSVDKIENKLEG" gene complement(3342..3821) /gene="" /locus_tag="" /db_xref="2104791..2105270" CDS complement(3342..3821) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MNKLSTIISTIPTAIIATIITIIVTHIREYIKDTKIKRKYAAIL YYDMNDSIDMIKSDMEGILKNQFTFIDKYKLYDYLVSVRDIISEDSFKNIKIYYKNLF LLENCWEKYWDCKDQKEIKLLEKDYYEAKNLLKSLYEDDKQGFINTISILKDIAKIK" gene 4070..4477 /gene="" /locus_tag="" /db_xref="2105519..2105926" CDS 4070..4477 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MNNKTKFLVPALAGIVLSSGLSLSNVQAKDVTANAKSSTLTVGV TSMSTSYQTYYSFGYADTNNMAVYLRIPGVTVSSFQGWLINEEGIPASVAVNVAPYLY SLGGDYIDSLNNGRGITVLKSTTSPVTYKVISA" gene complement(4572..4739) /gene="" /locus_tag="" /db_xref="2106021..2106188" CDS complement(4572..4739) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MINEIVVRIIAERILNKGLNPLKNREFVLEDVTNEDYRKAVEDY IIKNSGVVASQ" gene complement(4741..5067) /gene="" /locus_tag="" /db_xref="2106190..2106516" CDS complement(4741..5067) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MQIEKRIIFNKVTGTVLNGCLEERYDSGLTEKMINDLRPKEIDY LDLEYGSTILKNVDTYHIDVETKEIVIDKYKEHIETQEEKLKREKQELENQLLLKENK ETGGIL" gene complement(5079..6536) /gene="" /locus_tag="" /db_xref="2106528..2107985" CDS complement(5079..6536) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MIKSFPFNAVYDANGVPDRAYLAEDFAGYFAKFIGTGVYPNPAT GLQVVAVDGDMRIRIKKGYGYILGRDFENTDDYIFKLDPADGVLSRIDRVVLRLDYLD RKIKPILKKGNYGSSPIAPALQRNSDAYEIALADVYVRNGVISIMQSNITDLRLNKEF CGIVHAVIQQVDTTEIFRQFQAWFNEQKNVHEGDFEKWLNEFKIITGKKFTDWVDDLK NSLDPNEDIAAQLQMQISTVKSDLADITTYQTAGGTATSINLNLPTLVNGYATTFIAS SNNNKNATTINGKKLYKPNTTTTPNLTAGKAISVWYSATKDCFFIKASAEGNAIAENV LAGKTFSNDDDTDIAGTMPNRGTFNLGFGATVPAGYYSGGIVPNGKRLAYGELSVTIN TDRIMSITGLSFTPSKVIVSCYEYSNSPYTDSLNLIISNIADIYNMYGSFTDNSGDEI TSHGEKIKSKIITGGFNVYLPKIGNGGNLKYWAYE" gene complement(6543..7700) /gene="" /locus_tag="" /db_xref="2107992..2109149" CDS complement(6543..7700) /gene="" /locus_tag="" /product="hypothetical protein" /translation="LELYIFNRDLELIGILDTFTSLRWIRRYFKSGEFELHCALNFNT LELLKRDNVVYKKNDVEAGYIETRQLKIGEDGQEYLEVKGKFLTNYLDRRISWDRVSF SSKTEELMRKLVLENAISPTNINRKIPNLILGDLKGFKEDIKYANSFGNIIEQLENIS NTNNLGYRNILDIKNRKILFDIYKGVDRTINNGTIAPCIFSRDFENILEQEYMDSLNN YRNTTLIAGAGEGSARKITSIEEGVGLDRYELYVDARDITDKEEKKKTVLDYDEEGNV TGEHEETEEVEIPWERYKPLLLQRGKEKLSECEEIQTFDSKINTNGNNVYEKDFDLGD IVMIVDKKWGIRIDTRITEIEEIYEEKGLEVNVTFGNNIPTIIDKIKQKVR" gene complement(7704..8573) /gene="" /locus_tag="" /db_xref="2109153..2110022" CDS complement(7704..8573) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MNKKEKFIYENEKGQQIEFSIWSPFFLQNIDGISGLKNIIYSSK GMRQDGSTNTGNTLDDRNIVIQGAIIDNKEINREKLLSIINPKLQAKLIYTDGNIKKY VECKVETAPVIPKENNSKFQMSFLCNNPYWKDYIDSKVNIALWKGDFHFPLVIPQGKG ITMGHREPSLIVNVLNNGQVKTGMIIEFFARGTLKNPSLFNVNTREFIKINKAMAAGE KFIINTNYSKKKILQELNGVTTDILNYLDIEGGGDTFLQLNVGDNLFRYNADSNLDNL EVNIYFSPQYLGV" gene complement(8589..12515) /gene="" /locus_tag="" /db_xref="2110038..2113964" CDS complement(8589..12515) /gene="" /locus_tag="" /product="phage tail tape measure protein, family" /translation="MASNTEKRITAKMVLDSSGFNSSLKGVNAELKNAQSQMKLASSG IQAFGKDSEKLKSVQEALSKQVELHSQKVGIYTQSIEKTKSKLEDNIKVRDKLKENLS KAESQLKKVIDTHGKELQGYIKNKEELSKLNKEYEIAKKRYGENSTEANKLKEQISKL ENEQKKLTAEKEKEVKAYEKAKIEVDKTTKEYEKNEKAIDSNAKKIQQYDTNLNKAQS QMNKAQGELKKINEELDKQNNKWVSASNRLKDHSEKLKNTGKEITDVGKGINKLSLPI AAVGIGSAKAAIDFESAFTGVKKTVEGTDEQFAQLSKGIRNMSKEMPQSAVEISGVAE AAGQLGIKTENIQGFTKSMVMLGDSTNMSSEQAATSLARLANITQMPQTEFDKLGSVI VHLGNNLATTESEIVEMGLRLAGAGKQIGLTEAQTLGLSGALSSVGIEAEMGGSAISK VMVKMQAAATIGSDQAKKLSQATGMSMRELELLASNNGKAFKEVADSLNMTTAEMNAV IKSSKELDNFGKIAGMTGEQFKEAFQKDASTALIAFIRGLGNAENAGTSAIEMLEEMG IKEVRLRDSLLRAANAGTLLEDSINMGTKAWGENIALTNEANQRYETTESKLKMARNQ IVDAGISIGNNLLPALRDIAVSVAGMTEKFSHLSPEMQKGIVKFGAFVAITGPTVVGI GKVITGFGSIVSFGSKVAGIMGKVTLATKGVEVASVTAGATMATTGAKTGLLSTAFSG VKGAGGLAASGVVKLAGALGMSVPVLGIAVAGVAAVGYGAYKLHKNLKQEAVPSVDLF DKKLKTTQTTVDQYGNKMNTVITKTVNFTNQTKKAVGAYLEIDKKASSAMMSLVTNSD KFTKQAKDKVLKNFSDMSKKSSSLSNEQKNTMTTNFKKLVADTGVLTKKNKDEIIKQY TAMVNGTKGLNKKQKDQTIKEFTDTLNKSTAITKQQSSNLQQLYKDMGDKIKVGLDKK KEEELKSQQEFFSRSNVLTTTEEAKILQTTTTSWEDKKKTIDGLQNQINTIIKNAADN HRQITAEEAKTIDGLQNQMKENAVKTLSTSELEQKTIMERLKNYNGRITAEQASDTIK NAEKQRQGAVDKANKQYDGTVKQIIKMRDESKVITKEQADKMLKEAERQRKGSISKAN ELKDGVVKQIKKMNSDTLKDIDTTDGHIMTKWEKLKSWFANNPIIRWIKSKTSGDPEP QKKWTGDRYFSGGLTYLHDAPGRNSNYELYDLPRGTRIFNHDASQDLVMQTAESVATK VANNVLKGFNGSNGINVTQHIYSPVPTPSELARQSKNNLRELALNW" gene complement(12572..12691) /gene="" /locus_tag="" /db_xref="2114021..2114140" CDS complement(12572..12691) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MWGSHIKFNHWEIKDNNEENNPANDVNYKRVNIENIPFL" gene complement(12805..13197) /gene="" /locus_tag="" /db_xref="2114254..2114646" CDS complement(12805..13197) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MLNKIRKQKIGDKEYSFKMTNRTIRKIDEKYGNYGSVIYGLMEG QQFYTNALRLVSMCCVDKEKVLINKEENTYEEKIKEWDIEELENVITGQQYQEITNLA VELYIDYMGLNKDNEEETKNKEAKKEKN" gene complement(13255..13836) /gene="" /locus_tag="" /db_xref="2114704..2115285" CDS complement(13255..13836) /gene="" /locus_tag="" /product="phage major tail protein, Phi13 family" /translation="MDKVVPVVDLKKLYVAEVKEDGLTTTFDSTKYFEGVKELGIKPK INTDEYYAEGVLWLSETTLANIDVEVDITDLKKEEEAFLLGHKLANEGGIIRSANDKA PEVCLLYKAMKGNGKARYGIMYKGTFSLSDENYKGKEGKANFQSKKLKASFAPLHSNE MWNWKVDEEDGMTDEKFFKSVIIPTEKKENIEG" gene complement(13900..14256) /gene="" /locus_tag="" /db_xref="2115349..2115705" CDS complement(13900..14256) /gene="" /locus_tag="" /product="hypothetical protein" /translation="LDIKKKLLKVLNSKEVIDMLPDKRVYFLHAVNPDKKLYLEYEIV NEYGVEYSEGNEDYTTYIVQLDIFSTGDYIELENVVKKIMIHNGFNRDMAADLYEKET GLYHCAMRFNISLPID" gene complement(14272..14631) /gene="" /locus_tag="" /db_xref="2115721..2116080" CDS complement(14272..14631) /gene="" /locus_tag="" /product="phage protein, HK97 gp10 family" /translation="MANGIEIEGMEEFTDFLEDMTINESDEKKAVREAIKPIAQEIEK NTTKRTGKLSKLSKTVKREGLGTVGIIKTKAFYDIFEEFGTSIAKHNVGYFDRSIKNT EDKALEILAKELLNKTN" gene complement(14632..15000) /gene="" /locus_tag="" /db_xref="2116081..2116449" CDS complement(14632..15000) /gene="" /locus_tag="" /product="phage head-tail adaptor protein" /translation="MKVKIGEMRHRITIQKYNTYQNENGFDIEEWDDYKTVWASMNNL WGKEFYAAKSTNSENTVEFIVRYSKDLEKINSKEYRIKTIKDKNTTKEKDKYRYFDIT FIDNIKYENKWLKIKAIEVI" gene complement(14990..15283) /gene="" /locus_tag="" /db_xref="2116439..2116732" CDS complement(14990..15283) /gene="" /locus_tag="" /product="hypothetical protein" /translation="LIVTLEEIKQYLRIESDCIEEDSFLELVEKSAEQYIKNTTGKLF DDRNDLAKLACLIFICDRYENRGSADLTIKAQNALSYILTQLSYCYVGDKNES" gene complement(15368..16600) /gene="" /locus_tag="" /db_xref="2116817..2118049" CDS complement(15368..16600) /gene="" /locus_tag="" /product="phage major capsid protein, HK97 family" /translation="MTKVQEIQARIKEMKGEAKNLKTADDINVKIKEIEDLQAQLKIA EMEESDEKKALENKIKEGKMKNLSEEKDINNMGNKVIYNGNLFAKAIADATLKARNKK GFVFNEGEQRAISEHVGEDGGFAVPEDIKTEINKRLRDTTDISNLVNFEKVYTRSGQR TYEKRKKQTELTNLDEYGKIQEVDYRQLERISFKLHDCAGLKTIPNDLLEFAGEGLKN FIIEWLVDKVRFTKNIKILYGTGGENEVQGIMTFKDIKVIDLSATATIKDFKKLINVE LPSYYKTSATWVTNQDGYNFLDCLEDKQGHSYLRPDPKNDEVDKLLRKNVVELPNEVL ETKDGKIPVILGDLKSLYTYYSDGEYQLLSTNIGGGSFESNTTKTRLIYKMDGGIVDK DAVIIAYIPTIFVEKATK" gene complement(16653..17396) /gene="" /locus_tag="" /db_xref="2118102..2118845" CDS complement(16653..17396) /gene="" /locus_tag="" /product="serine protease" /translation="MSKFYEFKNKTDNNIDIYVYGEIIGGSEKWDESDVTFNDFKDNL EGLTGNETINMYINSIGGSVTTTQGIIAMLQRAKGKGVTINATIDGIGASCASFLPLV ADNVYAYKSSLLMVHHPYTLCIGNVDELQKQIDLLNKIENSVMMPLYLNKAKESITKD KIKNLVDKETWLNAKEMSEIFNIEILEDDKDLVACVKDKSILNKYTNVPKQLKNKLLE DKKTTVKTENVKDKEELELAKARLRLLYL" gene complement(17389..18639) /gene="" /locus_tag="" /db_xref="2118838..2120088" CDS complement(17389..18639) /gene="" /locus_tag="" /product="phage portal protein, HK97 family" /translation="MGIFNKMWSIKNTTTETVNQSDWFTSLIKSRTTTSGEKVTKESA LTISGVYACTDIIASSISKLPIHIYQKNKDGSNRVDNDVSYLLEKRPNLYMTPSTFKQ TLTVKLLLDGNTYVWVERRRGKAINLWILNNVQVLQDYTTGEIIYKATLNNKPYTFFN DEIIHIKSLSTDGILGKSKIDILRETIGNMQSSRKLLGNYFKNGTTTSGVVTYPEKLN SDAKAEIRRQWQENNSGYDNAGKVAVLDLGLEYKEINSLKFTDQQFLESTKFTLEEIA RVFKVPLHMINSLDRSTFNNIEQQSLDFYMNTILPLLLQIEEEFNYKLFSSTQREKYF IKFNMEGALRGDSATRSTYYEKMINLGVYSINEVRKLENMNSIGIQGDTHRVDLNHVD IKVANDYQLGKANSKKKGGEIDNE" ORIGIN 1 ttatttttca atttcatttt taattctctc cacttcagat attagctgat ttatccgtaa 61 ctctagctcc tctattttat caactttatt tttactagat gattttttat tataatcaga 121 attcgagttt ttttctttac ttttgcttga atttttacta ttcttgcttg agctattatt 181 ctgagtagta ttttgagaag tagtttggca aaatggatta tctacattat aattctgagg 241 attaaaatat ctccccggtc cttgttgaaa atatatttgt tgagcattaa atgttacaat 301 tgcctggcca actaacagta accaatttcc aagtgcagct tgaacattag cagggatact 361 gcctgctaat atatctccaa gtattcctcc tattgcaacg aataactgtg gatttaagga 421 ttgaaatcca ttaggtatat cataacatcc catattgcaa gattcatttg ttgcattatt 481 gttacttgtt tcacttgtat tatcactatc cttatgagag ttagtatatc cacaagctct 541 cgctaagtcc tcaaaactat tccatccatt gaatttcata tttcctctta atataagtgt 601 ttatatttat tgtattactt tcccatcaga attgttactt tttccataat ccatatttat 661 ttgctattta aacagtataa aaggcatttt tatataattt aattttaaat ttattgatat 721 aaaacaataa aatccatagc gatttttaca aagtttaccg tataagatat ctaacaaacc 781 catcaactaa gcgatttatc aaaccctatt ttttaacctt aatttatcag ctaccattgc 841 aataaactca gaatttgttg gttttccctt cccattattt atagtatacc caaatattcc 901 aagctattga tattgctagg tttaaacgat tttagcaatt tatatgtttt tctttaaaaa 961 tcatatacaa ataaaatttt cattcattta taggtatttt tttaattaat ttatacgtat 1021 tttgtaattg cctttattat actattattg catggtaata atcaagttat tttatataaa 1081 atacacttca taaaaataac aatttctatg tggtatacaa tataaatttg taaattaaag 1141 atattctaat actctatatt attatgttgt attatacaaa aaaataaaat aaggtaaagt 1201 aaattaatac tctaccttat ataatgtagt aaaaactcta atatttttta taaataatta 1261 tttaagatta aattgtattc ctttattatg ctctgttatt aattttagat tatcaatctt 1321 aatatcttta ggtatatcga atactaagaa agtattcttg tttattcctg cattaatttt 1381 atcataagac cctataaaat ttttattttc tctaaaaata gattcttggc tatttagatg 1441 ccctaatgct tcaaaagaat tatcatcaac tccatatgtt tttttcccat catttaattt 1501 aaattcatgt ggttcatatc ctgtagcttc ttcaccatta ttttttatat ctagttttat 1561 tactataaat ttcccacttg gtgttgattt cccagattca ttgctaatag caccattttc 1621 tttagcttct aaaattttaa tacttaaatt tcctacagga gactgttctc caaatttcac 1681 atccttcttt tcttctttta cttcctcttt tgtgctagaa acttgtttat ctacactttg 1741 accaatttgt ttattaactc tactaattgc tgtagcatca cctataaaat accctgcaat 1801 aaatataata agtccgccta ttattaattt aaaattcttt ttcatgtcct taatccccct 1861 cttgttaata tagtttaatt ataacaaaaa tgtaatattt gtaaataaaa tatcaaactt 1921 tggatatatt aagaacaaaa caatttacaa aatatcatgc aaaaaaatat aacttaatat 1981 tttacatact tcccataaat atatccacca tgtgaaggat aataaatatg tatccaatct 2041 ccctcttttc tatacaatct aacctttgct ccattaggta aagtccctaa tattctacta 2101 gaagtcgatt tcttttccct aacatttaca ccacttgggg tacatatagt acctgtttta 2161 ccatctagat taacccatcc attatttgta gatggttgac ttggtatact attgtttgta 2221 gttttttcta ctagtccttt aactatagca ttagccatat tttcggcatt atatctgctc 2281 atatcgtttc tattatcaca gaaacaacat tctataagca tagctttagc ctttgtatgc 2341 tttaatacat ataaattact accatctttt atacctctat ttgtataacc taaagtacaa 2401 atattattta atactcttga cgcttctgta aaagattttc ctccataagt taaaacctct 2461 gttccatagg cactgccatt aaaagcatta aaatgaatag atacatataa atctacatta 2521 taattattag ccatattagt tctataactt aaactatctt gtaaactgct gcaagtatcc 2581 ttataacact taataactgt atgccctaat gcttgtaatt tacttattac ttttgttcct 2641 acttctctag ttaaattaga ttctgctttt attcctactg ctccataatc agcaccactt 2701 aatgtatgcc cacaatctat ttctattttc attaattacc tacttccttc ctatccttac 2761 taaaataaaa tgctataatc atagtataaa tagttaaaaa ctccgtattt agggtatttc 2821 taattgctaa tatagcaaag acaatagtca tcattactgc tataagccac ctagcacttg 2881 ttatttttct taatgctcta ttcatactat ccctccaatt tattctctat tttatctaca 2941 cttcttttaa catcttctag tacatcaaat tttctagcta aatcaccaat aacttcttgg 3001 tttttatcaa ttgtactttg cattttttct tctctttcct ttgaagtttt aagtacaaaa 3061 tacaataagt aacaaaataa aactgcaaaa gctccttgac ttatcatata cttcatcatt 3121 tcttgttcca tataatacac atcctttctt tattattttt tagtttattt taaatttaat 3181 taacataact aaatttatgt aattatatta gtaaaaataa aaaaagacat tataaaaatg 3241 cctttaaatc ttaatttcag taaaataaaa aagactatat attaatagtc cctattttac 3301 ctttataaat tatttggttg tgtcgtctta actacttaat tgttatttaa tttttgctat 3361 gtcttttaaa atactaatag tatttataaa accttgctta tcatcttcat ataatgattt 3421 taacaaattc tttgcttcat aataatcttt ctctaataat tttatttcct tttgatcttt 3481 acaatcccaa tacttttccc aacaattttc taaaagaaaa agatttttat aatatatttt 3541 tatattttta aaactgtctt ctgatatgat atctctaaca gaaactaaat aatcataaag 3601 tttgtattta tcaataaaag taaattgatt cttaagaata ccttccatat cagattttat 3661 catatctata gaatcattca tatcataata taaaatagcc gcatatttcc ttttaatttt 3721 tgtatcttta atatattctc taatatgagt tactataatt gttataatgg ttgctataat 3781 agctgtaggt atagtactta ttattgtact taatttgttc atgctaaaaa cctcttctct 3841 taaatgtcat ataaatttaa aattacaccc aaagttaata ttctatattt tcacataaaa 3901 tcctctatat aaaatttatc tattacgtcg tattgttaat attttgttaa ttgttgttat 3961 ttgtaaatat ttttaattat ttgtaaataa aaaggaattt gtaaactaat atagaatttg 4021 tatatataaa catataataa aataatttca aagcaaagga gagaaaacat atgaataaca 4081 aaactaaatt tttagtacca gcactagctg gtatagtatt aagttctgga ctgtctttat 4141 caaatgtaca agctaaagat gtgactgcta atgctaaatc aagcacttta actgttggag 4201 tcacttctat gtcaacatct tatcagacat attattcttt tggatatgct gataccaata 4261 atatggctgt atatcttaga attccaggtg taacagttag ttcattccaa gggtggctaa 4321 taaatgaaga aggcatacct gcatctgttg ctgtaaatgt tgccccatat ttatatagcc 4381 ttggtggtga ctatattgac tccttaaata acggacgtgg aataacagta ctaaaatcca 4441 ctacttctcc tgtaacttat aaagtaattt ctgcataata acaggagcaa ttttatctct 4501 aaaaagttaa gagataaaat tgctcctgtt ttattagaaa gctttatttg ttattcttaa 4561 tatctctatt aactattgtg aggcaactac cccactattt ttaataatat agtcctctac 4621 tgcttttcta taatcttcat tagttacatc ttctaaaaca aactctctat ttttcaaagg 4681 attcaatcct ttatttaata ttctttctgc tattattcta actactattt cattaatcat 4741 attataatat gcctcctgtt tctttatttt cttttaataa taattgattt tctaattctt 4801 gcttttctct tttaagcttt tcttcttgtg tttctatatg ttctttatat ttgtctataa 4861 ctatttcttt agtttccaca tcaatatgat aagtatctac attcttcaaa attgtgcttc 4921 catattctaa atctaaataa tctatctctt taggtcttaa atcattaatc attttttctg 4981 ttagaccaga atcataacgt tcttctaaac agccgtttag aactgtgcca gtaactttat 5041 taaaaataat tcttttctct atttgcatta atatacctcc tattcataag cccaatattt 5101 taaatttccg ccattcccaa tttttggtag atacacattg aaacctccag ttattatttt 5161 acttttaatt ttttcaccat gactagttat ttcatcacca ctattatctg taaacgatcc 5221 atacatattg tatatatcag caatattaga aataataaga tttaagctat cagtataggg 5281 ggagtttgaa tactcataac atgaaactat tacttttgaa ggggtaaaac ttaaacctgt 5341 tatcgacatt attctatcag tattaatagt tactgataac tctccgtatg ccaatctttt 5401 accattcggt acaattccac cactataata accagctggt acagtagcac caaatccgag 5461 attgaatgtt cctctattgg gcattgttcc tgcaatatca gtatcatcat cattgctgaa 5521 agtctttcct gctagtacat tctcagcaat ggcgttcccc tctgcactag ctttgataaa 5581 aaaacaatct ttagtagcac tataccaaac ggaaatcgcc tttcctgcag ttaaattagg 5641 tgtagtagtt gtattgggct tatataattt tttcccattt atagttgtag catttttatt 5701 attgttacta cttgctataa atgttgtggc atatccattt actaaagtag gtaaatttaa 5761 atttattgaa gttgctgttc ccccagctgt ttgatatgtc gtaatatcag ccaaatccga 5821 cttaacagtg gatatttgca tctgcaattg tgcggcaata tcttcatttg ggtctagcga 5881 attttttaaa tcatctaccc aatcagtaaa tttcttacca gtaataattt taaattcatt 5941 taaccatttt tcaaaatccc cttcatgtac atttttttgc tcattgaacc acgcttgaaa 6001 ctgacggaaa atttctgtgg tatcaacttg ttgtataaca gcatgtacaa taccacagaa 6061 ttctttgtta agccttaaat ctgtaatatt gctttgcatt atacttataa caccatttct 6121 tacatataca tctgctaaag ctatttcgta tgcgtccgaa ttcctttgta aggctggagc 6181 aattggagaa cttccataat tccctttttt taatataggt tttatttttc tatcaagata 6241 gtctaatctt aataccactc tatctattct gctaagtaca ccatcagctg gatctaactt 6301 gaaaatataa tcatcagtat tttcaaaatc acgaccaaga atatacccat aacctttttt 6361 tattcttatt cgcatatcac catctacagc aactacttgt aagcctgtcg ctggattagg 6421 atatactcca gttcctataa atttagcaaa atatcctgca aaatcttctg ccaaataagc 6481 tctatctgga acgccattag catcataaac agcattaaaa ggaaaacttt ttatcatata 6541 tcattacctc actttctgtt taattttatc tattattgta ggaatattgt taccaaaagt 6601 aacattaacc tctaatcctt tttcctcgta aatttcctct atttctgtta ttcttgtgtc 6661 tattcttatt ccccattttt tatctactat cattactata tctcctaaat caaaatcttt 6721 ttcataaaca ttatttccat tagtatttat cttactatca aaggtttgta tttcttcaca 6781 ctcagataat ttttctttac ctctttgaag taacaaaggc ttataccgtt cccaagggat 6841 ttcaacttcc tctgtttctt catgttctcc agtaacatta ccttcctcat cataatctaa 6901 tactgttttt ttcttctctt ccttatctgt tatatctctt gcatctacat ataattcata 6961 tctatctaat ccaacacctt cttctataga tgttattttt ctggcacttc cttcacctgc 7021 tccagctatt aacgttgtat ttctataatt atttaaacta tccatatatt cctgttctaa 7081 tatattttca aaatcccttg aaaaaataca aggtgctata gttccattgt ttatggttct 7141 atcaacacct ttgtatatat caaataatat ttttctattt tttatatcta atatatttct 7201 atatcctaaa ttatttgtat tacttatatt ttctaactgc tctattatgt ttccaaagct 7261 gttagcatat ttaatatcct ctttaaatcc ttttaaatct cctaaaatta aatttgggat 7321 ttttctattt atattagttg gacttatagc attttctaat actagctttc tcattaactc 7381 ctctgttttg ctagaaaaac taactctatc ccagctaata cgcctatcta aataattagt 7441 aaggaattta cctttaactt ctaaatattc ctgtccatct tctcctattt ttaattgcct 7501 agtttctata taaccagctt caacatcatt ttttttataa actacattat ctctttttaa 7561 caattctaag gtattaaaat tcaaagcaca atgtaattca aattctccac ttttaaaata 7621 cctcctaatc caccttaaag atgtaaaagt gtctaatata cctattaatt ctaaatccct 7681 gttaaatata tataattcca ataattacac ccccaaatat tgtggactaa aatatatatt 7741 aacttccaag ttatctaaat tactatctgc attataacgg aataaattat ctccaacatt 7801 tagctgtaga aaggtatctc ctccaccttc gatatctaaa taatttaata tatctgtagt 7861 aacaccatta agctcttgta atattttttt cttactatag ttagtattta ttataaattt 7921 ttctcctgca gccattgctt tatttatttt tataaactct ctagtgttta cattaaataa 7981 agatggattt ttaagagtac ctcttgcaaa aaattctatt atcatacctg ttttaacctg 8041 tccattattt agcacattaa caataagact tggttctcta tgtcccatcg taatgccttt 8101 cccttgtgga atcactaaag ggaaatgaaa atcacctttc cataatgcta tattaacttt 8161 actatcaata taatctttcc aatatggatt attacataaa aaactcattt gaaatttaga 8221 attattttct ttaggtataa caggtgcagt ttccactttg cattctacat atttttttat 8281 attcccatct gtataaatta atttagcctg taattttggg tttattatgc ttaatagttt 8341 ttccctatta atttctttat tatctataat tgcaccttgg ataactatat ttctgtcatc 8401 caaggtgtta cctgtattag tagatccatc ttgtctcatt cctttactac tgtaaataat 8461 attctttaaa ccacttatac catctatatt ttgtaagaaa aaaggactcc aaatagaaaa 8521 ttctatctgt tgtcctttct cattttcgta tataaatttt tcttttttat tcatatcacc 8581 acctcacttt taccaattta gtgctaattc tcttaaattg tttttagatt gtctagccaa 8641 ttcgcttgga gttggtactg gagaataaat atgttgtgtt acatttattc cattactgcc 8701 attaaatcct tttaatacat tattagctac ctttgttgct acgctttcag ccgtttgcat 8761 aaccaaatct tgacttgcat catggttaaa tattctagtt cctcttggga gatcgtaaag 8821 ttcataattg ctatttctac ctggagcatc atgtaaataa gtaagtcctc cgctaaagta 8881 tctatctcct gtccattttt tttgtggttc ggggtctccg ctagttttag acttaatcca 8941 tcttataatt gggttgttag caaaccaact ctttaacttt tcccatttag tcattatgtg 9001 tccgtctgtt gtatcaatat ctttaagagt atcactgttc atttttttta tttgctttac 9061 aactccatcc ttaagctcgt tagccttact aatagaacct ttcctttgtc tctccgcttc 9121 ctttaacatt ttatctgcct gctcttttgt tataacctta ctttcatctc gcattttaat 9181 tatttgttta acagttccat catactgttt attagcttta tctactgcac cttgcctttg 9241 cttttctgca ttttttattg tatcagaagc ctgctctgct gttattctcc cattatagtt 9301 ttttagtctt tccattatcg tcttttgttc aagttcagat gtacttagtg ttttaactgc 9361 attttctttc atttgatttt gtaaaccgtc aattgttttg gcttcctctg ctgtaatttg 9421 cctatgatta tcggctgcat tttttataat agtattgatt tgattttgca atccatcaat 9481 tgtctttttt ttatcttccc aactagtcgt ggttgtttgt aatattttag cttcctctgt 9541 tgtggtcaaa acattacttc tgctaaaaaa ttcttgctgg ctttttaatt cttcttcctt 9601 ttttttatct aatccaacct taattttatc ccccatatct ttgtataatt gctgtaaatt 9661 agaagattgt tgcttagtaa ttgcagtgct tttatttaaa gtgtctgtaa actcttttat 9721 agtttgatcc ttctgttttt tgttaagtcc tttagttcca tttaccattg cagtgtattg 9781 ttttattatt tcatctttat tttttttagt tagtactcct gtgtcagcaa ctaatttttt 9841 aaaattagtt gtcattgtat ttttttgctc atttgaaagt gaactagatt ttttactcat 9901 atcactaaaa tttttaagaa ctttatcttt agcttgctta gtaaatttat cagaatttgt 9961 taccaaactc atcattgcac tacttgcttt tttatctatt tctaagtacg ctcctactgc 10021 tttttttgtt tgatttgtaa aattaactgt cttggttatc acagtattca ttttgttacc 10081 gtattgatct acggtagttt gggtggtttt taatttttta tcaaacaaat caacagatgg 10141 gactgcctct tgtttaagat ttttatgcaa tttatatgct ccatatccta ccgctgctac 10201 tcctgccact gcaatgccta gcactggaac agacattcct aatgctcctg ctaattttac 10261 aactccactt gctgctaaac ctccagcacc tttaactcca ctaaatgctg tacttaataa 10321 tcctgttttt gctcctgttg ttgccattgt agctccagcc gtcacacttg ctacttctac 10381 cccttttgta gcaagtgtta ccttgcccat tattccagcc actttacttc cgaaacttac 10441 aatgctaccg aatccagtta ttacttttcc tataccaact acagtaggtc ctgtaattgc 10501 tacaaatgca ccaaatttaa caataccttt ctgcatttct ggacttagat gagaaaattt 10561 ttctgtcatt cctgcaacgc taactgctat atctcttaat gcaggtaaca aattattacc 10621 aatacttata cctgcatcta ctatctgatt tcttgccatt tttaacttac tttctgtagt 10681 ctcatatctt tggtttgctt cgttagtaag agcaatattt tctccccaag ctttagttcc 10741 catatttata gaatcttcta ataaagtacc tgcatttgct gctctaagta aactgtctct 10801 aagtcttact tcttttatac ccatttcttc tagcatttct atagctgatg ttccagcatt 10861 ttctgcatta cctaaacctc ttataaatgc aataagtgca gtggatgcat ctttttggaa 10921 cgcttcttta aactgttctc ctgtcattcc tgctatttta ccgaagttgt ccaattcttt 10981 agagcttttt attacagcat tcatttctgc tgtggtcata ttcaaagaat ctgcaacttc 11041 tttaaatgct ttcccattat tggacgctag aagttcaagt tctctcatag acattcctgt 11101 tgcctgagat aattttttag cttgatctga gcctattgtt gcagccgctt gcatcttaac 11161 cataactttg gatatagcag aaccacccat ttccgcttct atccctacag aacttaatgc 11221 acctgataaa cctaatgttt gtgcttctgt taagccaatt tgtttacctg ctcccgcaag 11281 tcttagcccc atttctacaa tttctgattc tgttgtagct aaattattgc ctaggtgaac 11341 tataacagaa cctaacttat caaattcagt ttgtggcatt tgtgtaatat tagctaatct 11401 agccaatgaa gtagctgcct gttctgagct catgttagtt gaatctccta acatgaccat 11461 ggatttagtg aatccttgaa tattttctgt ctttatacct agctgccccg ctgcctccgc 11521 aactcccgat atttctacag cactttgtgg catttcttta gacatatttc ttatgccctt 11581 gcttagttga gcaaattgtt catctgttcc ttcaacggtc tttttcactc cagtaaatgc 11641 actttcaaaa tctatagctg cttttgcact tccaatacca acagcagcaa tgggaagcga 11701 taatttattt attccttttc ctacgtcagt tatctcttta cctgtgtttt ttaatttttc 11761 tgaatgatct tttaatctat tactggcact tacccattta ttattttgct tatctaattc 11821 ttcatttatt ttttttagtt ccccttgagc tttattcatc tgagattgtg ctttatttag 11881 attagtatca tactgttgta ttttttttgc attactatct atggcttttt catttttttc 11941 atactctttt gttgttttat caacttctat tttagctttt tcatatgctt ttacttcttt 12001 ttctttctca gctgtaagtt ttttttgctc attttctagc ttactaatct gttcttttaa 12061 tttattagct tctgtactat tttctccata tcttttttta gctatttcat attctttatt 12121 taattttgat aactcttctt tattttttat atacccttgt agttctttcc catgagtatc 12181 tataactttt tttaactggc tctctgcttt agataaattc tcttttaact tatctctaac 12241 ttttatatta tcttctagtt tagatttagt tttttctatg gactgcgtgt atatgcctac 12301 tttttgggaa tgtaattcta cttgtttaga aagtgcctct tgtacagatt ttaatttttc 12361 gctgtctttc ccaaatgctt gtatcccaga actagctaat ttcatctggg attgtgcatt 12421 ttttaattct gcatttacac cttttaagct ggaattaaat ccgctgctat ctaataccat 12481 ttttgcggtt attcgttttt ctgtattgct agccattatt cccctccctt ctaaatcttt 12541 ctataaaaaa gacacttatc aaagtgccta tcttatagaa atggtatatt ttctatattt 12601 actcttttgt aattcacatc atttgcaggg ttattttctt cattattatc tttaatttcc 12661 cagtgattaa atttaatatg gcttccccac atcttgtata tttccgcatg tgtactatcc 12721 caaaattctt ctttagaata atttaaatgt acttttgcta aataaaaaag ccagtcaaag 12781 tcaatttcat acttcgactg gtcatttagt ttttttcttt tttagcttct ttattttttg 12841 tttcttcttc attgtcttta ttcaatccca tataatcaat ataaagctcc actgctaagt 12901 ttgtaatttc ttgatattgc tgtcctgtta taacattttc tagttcttca atgtcccatt 12961 cttttatttt ttcttcatat gtattttctt ctttatttat aagtactttt tctttatcta 13021 cacaacacat agatactaat cttaaagcat ttgtgtagaa ttgttgtcct tccattaacc 13081 cataaataac agaaccataa ttaccatact tttcatcaat ctttctaatg gttctattag 13141 tcattttaaa agaatactct ttatcaccta ttttttgttt tcttatttta tttaacatat 13201 tatccaatcc tttcatcaac aaaataataa gggtagatta tttctacccc ataaattaac 13261 cttctatatt ctcttttttc tctgtaggta ttattacaga tttaaagaat ttttcatctg 13321 tcattccatc ttcttcgtct actttccaat tccacatttc attagaatgt aaaggtgcaa 13381 aagatgcttt taatttttta gattggaaat tagcctttcc ttccttacct ttatagtttt 13441 catcacttaa agaaaatgta cccttgtaca ttattccata tctagccttt ccgttgcctt 13501 tcattgcttt ataaagtaaa caaacttctg gtgccttatc attagcactt cttataattc 13561 cgccctcatt tgctaactta tgacctaaaa gaaatgcctc ttcttctttt tttaaatctg 13621 taatatctac ttctacatct atattagcta atgtagtttc gctaagccat aatacacctt 13681 ctgcataata ctcgtcagta ttaattttag gttttattcc taattctttt acaccttcaa 13741 aatattttgt actgtcaaaa gttgttgtta acccatcctc tttaacttca gctacatata 13801 atttttttaa atccacgact ggtactactt tatccatatt aaaatttcat cctttcaatc 13861 tttaaattaa tttttcacat aaaaaaagac tagttttaaa ctagtcaatt ggtaaactta 13921 tattaaatct cattgcacaa tggtataagc cagtttcctt ctcataaagg tcggctgcca 13981 tatctctatt aaatccatta tgtatcatta tttttttaac tacattttct aactctatat 14041 aatctccagt agaaaatata tctaattgta ctatgtatgt tgtataatcc tcattacctt 14101 cgctatattc tactccatac tcattcacaa tctcatactc aagatataac tttttatcag 14161 gattcaccgc atgtaaaaaa tatacacgct tatcgggtaa catatctatt acttctttag 14221 aatttaatac ttttaataat ttttttttta tatccaatta ccaccaccta ctttagtttg 14281 ttttatttaa taattctttg gctaatattt ctaaagcttt atcctctgta ttttttatac 14341 ttctatcaaa atatccaaca ttgtgtttag ctatactagt cccaaattct tcaaaaatat 14401 cgtaaaaggc tttagttttt attattccta cagttcctaa accttctctt tttactgttt 14461 tagatagttt agatagctta ccagttcttt tagttgtatt tttctcaatt tcctgtgcaa 14521 taggttttat agcttctctt acagcctttt tttcatcaga ttcattaata gtcatatcct 14581 caagaaaatc tgtaaattct tccatacctt caatttcaat tccattagcc atttaaatca 14641 cctcaatagc tttaattttt agccacttat tttcatattt aatattgtct ataaaagtta 14701 tatcaaaata tctatattta tctttttctt ttgtagtatt tttatctttt atagttttaa 14761 ttctatattc cttagaatta attttctcta aatctttaga atatctaact ataaattcta 14821 ctgtattttc agaatttgta gactttgctg cgtaaaattc tttaccccat agattattca 14881 tacttgccca tacagtttta taatcatccc attcttctat atcaaatcca ttttcatttt 14941 gatatgtatt atatttttga atagttattc tatgtctcat ttctcctatc ttaactttca 15001 tttttatcac ctacataaca ataacttaat tgtgtaagta tataacttaa cgcattttgt 15061 gcctttatag ttaaatcagc acttcctcta ttttcatacc tatcacagat aaaaattaaa 15121 cacgctaact ttgctaaatc atttctatca tcaaatagtt ttcctgtagt atttttaata 15181 tattgctctg cacttttttc cactagctct aaaaagctat cttcttctat gcaatccgat 15241 tctatcctta aatactgttt tatttcttct agtgttacta tcaatctaat cacctacttt 15301 attaaaaaaa gacataaaaa aagaacctat ataggaactt aatttatatc cttatattta 15361 gtttttagct atttagtagc tttttcaaca aatattgtag gaatataggc aattattaca 15421 gcatccttat ctacaattcc cccatccatc ttatagatta atctagtttt agttgtatta 15481 gattcaaaag aaccaccacc aatattagta gataaaagtt gatattctcc atcagaataa 15541 tatgtatata aagattttaa atcacctaaa attactggaa ttttaccatc cttagtttct 15601 aatacttcat ttggtaattc aactacattt tttcttaata atttatcaac ttcatcattc 15661 ttaggatctg gtcttaaata agaatgacct tgtttatcct caaggcaatc taagaaatta 15721 tatccatctt gattagtaac ccaagttgca gaagtcttat aataagaagg taattcaaca 15781 tttattaact ttttaaaatc ttttatagtt gctgttgctg ataaatcaat aacttttata 15841 tccttaaaag tcattattcc ttgtacttca ttttctcctc cagtgccata aagtattttg 15901 atatttttag taaatctaac tttatccact aaccattcta ttataaaatt ctttaaccct 15961 tctcctgcaa attctagtaa atcatttggg atggttttaa gtcctgcaca atcgtgtagt 16021 ttaaaagaaa ttctctctaa ttgtctataa tctacttctt gtatttttcc atactcatca 16081 agattagtta attcagtttg cttttttctc ttttcatatg ttctttgtcc acttctagta 16141 taaacttttt caaaattaac tagattagat atatctgtcg tatctcttaa tctcttattt 16201 atttcagttt ttatatcttc aggtactgca aagccaccat cttctcctac atgttcagat 16261 atagcccttt gttccccttc attgaataca aatcctttct tgtttctagc tttcaatgtt 16321 gcatctgcaa ttgcttttgc aaataaattt ccattatata tcactttatt tcccatatta 16381 ttaatatcct tttcctcact taaatttttc atttttcctt cttttatttt attttctaat 16441 gctttctttt catcactttc ctccatttct gcaattttta actgagcttg caaatcttca 16501 atttctttta tttttacatt tatatcatca gcagttttaa gattcttagc ttcacctttc 16561 atttctttta ttcttgcttg tatttcttgt acttttgtca tattactaat caatcctttc 16621 attttaaaat ttaatttttg aataaaaaaa agactataaa tataatagtc taagtctagc 16681 ttttgctaat tctaattctt ctttatcttt tacattctct gtctttactg tagttttctt 16741 atcttctaat agtttatttt taagttgttt aggtacattc gtatatttat ttaatataga 16801 tttatctttt acacaagcta ctaaatcttt atcatcttca agtatttcta tattaaatat 16861 ttcactcatt tctttagcat ttaaccatgt ttctttatca actaaatttt ttattttatc 16921 ttttgttata ctttctttag ctttatttaa atatagtggc atcattacac tattttctat 16981 tttattcaat aaatctattt gtttctgcaa ttcatcaaca tttcctatac ataaagtata 17041 aggatgatga accattaata aactagattt ataagcatac acattgtcag ccactaatgg 17101 taaaaaactt gcacaactag caccaattcc atctatagta gcatttattg ttacaccttt 17161 tccttttgct ctctgtaaca tagcaataat accttgtgta gttgttacac taccaccaat 17221 agagtttata tacatattta tagtttcatt tcctgttaaa ccttctaaat tatccttaaa 17281 atcattaaat gttacatctg attcatccca tttttcagaa ccgcctatga tttcaccata 17341 aacatatata tctatattgt tatccgtctt gtttttaaat tcataaaact tactcattgt 17401 ctatttcacc acccttcttt ttagaatttg ctttccctaa ttgataatca ttagctactt 17461 ttatatcaac atgatttaag tcaactctat gagtatcgcc ttgaatacct atagaattca 17521 tattttcaag ctttcttact tcattgatac tatatactcc taaatttatc attttttcat 17581 aataagtact tctggtagca ctatctcccc ttaaagcacc ttccatatta aatttaataa 17641 aatatttttc tctttgtgta ctactaaata atttataatt aaattcttct tcaatttgca 17701 atagtaaagg taatatagta ttcatataaa agtccaaact ctgttgttct atattattaa 17761 aggtacttct atcaagagaa ttaatcatgt gcagtggtac tttaaatact ctagcaattt 17821 cttcaagtgt aaattttgta gattctaaaa actgttggtc agtaaatttc aagctattta 17881 tttccttata ttctagtcct aaatctaata cagcaacttt tccagcatta tcatacccac 17941 tattattttc ttgccattgt cttcttattt ctgcttttgc atcagaattt agtttttctg 18001 gataagttac aacaccactt gtagtagtac cgtttttaaa ataattacct aataattttc 18061 tactactttg catatttcct atagtttctc taagtatatc tattttactt tttcctaata 18121 ttccatctgt agataaactt tttatatgta ttatttcatc attaaaaaag gtatacggtt 18181 tattatttaa agttgcttta tatataattt cacccgttgt ataatcttgt agaacttgta 18241 cattattcaa gatccaaagg ttaattgctt tacctcttcg cctttctacc cacacataag 18301 tattaccatc taacaataat ttaactgtta atgtttgctt aaatgtgcta ggtgtcatat 18361 atagattagg tctcttttca agtaaataac taacatcatt atcaactcta ttactgccat 18421 ctttattttt ctgatatatg tgaataggca acttagaaat agagcttgca attatatcag 18481 tacaagcata tacaccacta attgttaaag cactttcttt tgttactttc tctccacttg 18541 ttgtagttct actttttatt aaacttgtaa accaatcact ctgatttact gtttcagttg 18601 ttgtattttt tatagaccac attttattaa atatgcccat //