LOCUS NC_012225:26 18058 bp DNA linear BCT 26-AUG-2011 DEFINITION Brachyspira hyodysenteriae WA1, complete genome. ACCESSION NC_012225 SOURCE Brachyspira hyodysenteriae WA1, complete genome. COMMENT locus start: 2474042; locus end: 2492099 FEATURES Location/Qualifiers source 1..18058 /organism="Brachyspira hyodysenteriae WA1, complete genome." gene 0..608 /gene="" /locus_tag="" /db_xref="2474042..2474650" CDS 0..608 /gene="" /locus_tag="" /product="two-component response regulator" /translation="MNNTEELIYDDDDMLSPIDAAKIVGVSRTTVNYWVRHYGLKADV TPGKRYKIRYADLKAFLAFNKKEKRIKLKRKQSKYKLAIIEPMEVTRKNYLEWLKDDY DVTCISNLAAPLKELKKISPDIILMDINLSDDKDYFYLIDEIKKEISLRTSLIIIITK RYNEDDVVNGLEKGACDYVKKPVGQNELKARIKNAIRFYVDV" gene complement(621..2606) /gene="priA" /locus_tag="priA" /db_xref="2474663..2476648" CDS complement(621..2606) /gene="priA" /locus_tag="priA" /product="primosome assembly protein PriA" /translation="MYVKVVFNLPIDRILTYRKPDEINDSLVGCRVVAPIKGKNNKGI VVEEVETIDGNYKVYPIKARIDLEPICSDKEFKLAKWMSNYYHSSFGEALFAALPVGT PAKKEKKAKPIPAKQKPYLKLNEEQEAVLKKINESIDSNNPKTFLLHGVTGSGKTEVY LQAIKKVVDMGKQAIVILPEISLTPQTIKRFAERFEGKIAVLHSKLSPNSKYRYWQMI KKDEIKIVIGARSAIFSPTPNLGIIVIDEEHETSYKAGDTPRYHARQVAFYRKSQENA TLLLGSATPSIESFYYASIGKIELLSLKKRAASVNMPEVKILDLKKEKRADAFPMITQ KLVEEINKKLEKKEQIILFLNRKGYAPVVSCSYCQRVLECPNCSVSLTYHKKKNVVMC HYCGYTQYLDELCDECKIGHFERIGSGTEKVEEHLNILFPNAVVERMDQDTVGGTKNY EKIFKRFSDGEIDILVGTQMIAKGLDFPNVTLVGVLFADMSLHIPDFRSAERTFNLIT QVAGRSGRGDKKGIVYIQTYSPNNYSIECAKNHDYISFYNKEIENRKAPLNYPPFSRL VRLVIRGIDEKKVENDANKIADMLRMETYNDSDKIIILGATACAMSKLNKYYRWNILI KTPSHSLLKNFFNKLNTNFAADKGNYIEIDIDPINML" gene complement(2609..2974) /gene="dksA" /locus_tag="dksA" /db_xref="2476651..2477016" CDS complement(2609..2974) /gene="dksA" /locus_tag="dksA" /product="DNA-binding transcriptional regulator of transcription, DnaK suppressor protein" /translation="MTAKKLKKFKDLLLEEKRKTLDELLSGNETYEALKDDSHGDMVD IAFQAYEKQNLMNFSQKEKDKLDMLNNALKRIEEGTYGKCIDCKEEINEERLTALPYT LRCVNCMSKYEDKKRREKM" gene complement(3017..3415) /gene="rpsI" /locus_tag="rpsI" /db_xref="2477059..2477457" CDS complement(3017..3415) /gene="rpsI" /locus_tag="rpsI" /product="30S ribosomal protein S9" /translation="MASKQLTIFTGKRKTANARVRITLGSGKILINGKNYAEYFCNRA ALLKVVEDALKVTGNFGKYDVFANVHGGGVSAQADAVRHGIAKALVGESQDFRTTLKR NGFLTRDSRVVERKKYGRSGARKRFQFSKR" gene complement(3429..3893) /gene="rplM" /locus_tag="rplM" /db_xref="2477471..2477935" CDS complement(3429..3893) /gene="rplM" /locus_tag="rplM" /product="50S ribosomal protein L13" /translation="VYVMDKKTLKTKNSTYVLSQKDIKQNWLIIDAKGKSLGRVASRA AYMLKGKHKVDYAYNLDNGDYVIIINAKDIVLTGNKKKGKIHYRHTGYPGGIKAISYG ELLEKNPERMVKIAVKGMLSHNPLGRLHLKKLKVYAGSEHPHEANKPTVVNI" gene complement(3992..4201) /gene="" /locus_tag="" /db_xref="2478034..2478243" CDS complement(3992..4201) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKKISKIVKIIGIKKLKGIIKIIGIKNIPKVIKSKNIIDVVKIV GINKSVRIIKLIGIKTSFQIARIIL" gene complement(4225..5061) /gene="panC" /locus_tag="panC" /db_xref="2478267..2479103" CDS complement(4225..5061) /gene="panC" /locus_tag="panC" /product="pantoate-beta-alanine ligase; pantothenate synthase" /translation="MALTILKNIKSAYKFISDNKDKTIALIPTMGALHEGHAALIKKA KKECNIVIVSIFLNPLQFTKVEDIEKYPEDLDKDKKLLSELQVDVLFLPSVEEMIPDD YAMHINIENNKFNIISRPIYYRGIITITLKLFNIISPTYVYLTEYDYQEMFIIKKIIK DLNYNIALKTIPIVRDENMLALSSLNSLLSEREKEEATIIYKLLKEAREEFKKGGNKS SYLIDIIKNNLKSHKMLKLEYIYIADKETLANVETATRNSIILISCYCGSTRLLDNMP LK" gene complement(5065..5526) /gene="" /locus_tag="" /db_xref="2479107..2479568" CDS complement(5065..5526) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MAKTIKCKSCKTVNDKYAKQCRSCGTLLYPEISHKNAELISIIL DGIFAFIYLFGIYLFIVNCNNDEIPKYITILPAPNTLPYFLIILLFLAFAASKILYIV NVFVLKKDIIFTIRRFSMFIEAIIMFPLQTILALYFYEPATNQDKMNKKMD" gene complement(5732..8926) /gene="" /locus_tag="" /db_xref="2479774..2482968" CDS complement(5732..8926) /gene="" /locus_tag="" /product="acriflavin resistance protein ; heavy metal efflux pump; cation/multidrug efflux pump" /translation="MERIIVFFAKKTMLVNIIVMAILFVGGYYYFNLRKESIPSTDLD MMLISVVYPGATPLDVEQNAVIPIEEELQGISGIDEYNTTIIENAAIILVKLDETIPN RQPVKDEIFRQMQNVPDLSEDVEEVTTYDLNPNKMDIYTLAVHFKEGMEGDERELFDF SQRLENELVRLEGVSEIRVDGRTDPEIKVYVDPIKMQQNYIALSDVVNALSIRNIRAT GGDIETGGKEQTVVTYGEFQDPMEASNVIIRSTFNGQRVRINDIANVKSGFEDKTVYM RVNRAAGYSLSVVKNENADILKTIDVVNQYLAENADIVPDNIQVSVMGDKSRTIKSLL SIVTSNLIQGFIIIFITLIIFLDFKSAMFTSLGMILTMFACFIYMQVAGITFNTMSLA AIITVLGMIVDNSIVVSENIFNFKQAGYKGLEATRLAVSDVVMPMLASTLTTVAAFFP MLTISGIMGKILNLFPRIVIFTLVVSMLQAVLILPNQLQDKEDKYKSYKPKKKSKFKN PLDFDKDALFDKMKIPFGAILEKLIHVRYIVIGFFILMFIASIFLAQNSFKNFVLIYD TSADTIVINIEMPTGTTKEVTTQQIAKIEDAVSKVVKPEELIALYSLVGKQVDQEIVS EEKGSLAGIMVYLVPAAERTRTADELVALINQEIDKTDIRQTVPIFMMNTKGSVDPGD PVDIKIVGNDTELAKKAKDEIKAFLATVPGVIDIDDDDKIGKEELRVMLDYNKIAELG VSVANVANEVRTAYYGTEATYIQELENKLDFRVVFDDQFTYDAKYLNDLLIPNSQGRL IYLKNIASVEKANGLSTLKHYNGERTITITAGIEYGKNTSQQVMAAVSERFKDFNKEY RGLKLEFGGEAKETMKAIKQLLFSFAMAFIFVYIVLLLQLNRFIQPIMIMIIIPFGLI GVLLGFAIHKMPLSFMGVVGIIGLAGVVVNNGIILVDLINKIIDEGVEGGKKGVAKAI VDGAKQRLRPVFLTTVTTVVGLLPTVYGIGGRADIIIPIVMALAYGLLFASLLTLIFL PCMFMIMFDLRLIKIPPTKNPSEEITTTITTAGH" gene complement(9078..10532) /gene="tolC" /locus_tag="tolC" /db_xref="2483120..2484574" CDS complement(9078..10532) /gene="tolC" /locus_tag="tolC" /product="integral outer membrane protein TolC, efflux pump component" /translation="MKISVKIILCSIVFINILYGQTNTLTYAAYMETIRDQIPELKIN AVTETNAQMNLLSAESSGDVNLSAQFGAVGKYGSLSSGYTSTTASPSVNAAGIQAGIG LGSLIPYTGTKWSVNLTHTSFLGGKLNMPGGQSVDFNNYQPSLTLEVTQPLLRNFFGT LDKYPIKDAEYALAIAKLQRKLDDASVIVSYQKIYYQWIMYEKLLAYYRNMYITAKRF ENQMRDRYNNGLIDNDSYQNARTQTMVYSDYYAQNQVYLDSLLATVSFFMPVTNIKPD HTTWDAYLDLGSNMQMEAVPFADSINGQIAYQSKIRAEYTLDAMKNGTLPNLDFVGSV SLNGLSPNTEGYFKSFGSMTNVDFFAGVQFSYPLGNRANKAQYQMAENSLYGIIAQYD QLEKDFNTQLQTYISKFNAYKNLIASKQMQIRAINSRIATQLQKLDQGRLEIDDLLTS RLELVATQTELLNLQYEFITTIFDYRALLAIDYE" gene complement(10601..11329) /gene="yfiR" /locus_tag="yfiR" /db_xref="2484643..2485371" CDS complement(10601..11329) /gene="yfiR" /locus_tag="yfiR" /product="hypothetical protein" /translation="MPKVNQEYFENKRKIILDAAMSVFFKKPAYSVRMKDIVKESGLS QGGVYKYYSNIDEIVIALINSNKTEVNPRDIIENYYDEPEKAIFELFDAFRKFFFITA KEFGKIMFELQAMFFNSKERMQKLKDNINKDLVLNYWFSELLIFIDKKIDEKYFNPVI DPQDIYMQMIVAASGIGNELILNKYYNLDRKLYYYKGDEENIYHGEAGRTLDVNLDNL IDTLYKTLLLLLGSKNIHKYSFKN" gene 11626..11961 /gene="" /locus_tag="" /db_xref="2485668..2486003" CDS 11626..11961 /gene="" /locus_tag="" /product="anti-sigma factor antagonist" /translation="MEVNIKELENNTVILKLDGDIDVYTSSDLKDSIFSQIELGAKKI IIDMEDVYYIDSSGIGVFISALGTFKKVNGKICFVKVTDPVKKVFELTKINSFFPVFT TETEALANF" gene 12123..13034 /gene="atpB" /locus_tag="atpB" /db_xref="2486165..2487076" CDS 12123..13034 /gene="atpB" /locus_tag="atpB" /product="putative F0F1-type ATP synthase, subunit A" /translation="MIKELFLLRKVFILTLILSCVFSVNVLYGAETINDYIMEEITDN TSHPFYTIPIKFGKYIDFDFKITKHIILVTLAGILSVCSMKYLAHKLKRPLNRPTYLQ SILEGLIDYMNKDVIGATLGEEGKKYVPFCLTVFLFVLFSNILGLIPASIKFPTEDGN HSYIAGGLGANIGFTAAIAIVVFIVYIVAGIRKKGIIKYWTSLVPKGLPIPLIPIIWV LEFITLFNRAFALAIRLFANITGGHIMMIVIPYLIVMSGTLLVSPFAVLFLGFIYVLE MFVAVLQAYIFSLLSAVYIGIAISDEH" gene 13071..13292 /gene="atpE" /locus_tag="atpE" /db_xref="2487113..2487334" CDS 13071..13292 /gene="atpE" /locus_tag="atpE" /product="putative F0F1-type ATP synthase, subunit C" /translation="MELSILGAAIGAGLAAIGVGLGIGFIGSRAVEGIARQPEVSGKI QTAMLIAAALIEGVGLFALVICILALFTK" gene 13328..13831 /gene="atpF" /locus_tag="atpF" /db_xref="2487370..2487873" CDS 13328..13831 /gene="atpF" /locus_tag="atpF" /product="putative F0F1-type ATP synthase, subunit B" /translation="MALLKIDPGIIIWTWITFLLVLAILGASTWKIILKGLNARADKI QEDLEEAEKTRENAKKSLAAYREQIDNAKVEASAIIENARVEANRIRDKIINNAREEA ELNKNKIMSEIDRSKEEAMNSVKKQALDIAVVMAETILKRNINKEDNQALINEFINNA NKENSQK" gene 13868..14416 /gene="atpH" /locus_tag="atpH" /db_xref="2487910..2488458" CDS 13868..14416 /gene="atpH" /locus_tag="atpH" /product="F0F1-type ATP synthase, delta subunit" /translation="MKESDKLQILKPTASAIFDIARELGMIKEIYNELSECSKLFQDI DIKKYFFDKSISKKDKKELIDKRLKPILSKETYAFVSILTEHDSIDVLPDIVALYKEI ADDYSNIVRVRIITASTIDDKTVEDIIQTVKCFSSNEISYETIVDENIIGGIIVYIGS VVYDYSIKKQIDLLQSKFTYGN" gene 14442..15083 /gene="atpH" /locus_tag="atpH" /db_xref="2488484..2489125" CDS 14442..15083 /gene="atpH" /locus_tag="atpH" /product="F0F1-type ATP synthase, delta subunit" /translation="MDPIAENILSDLKKEVLREVTREKASRFSRIVKNESSAKNYAKA MFDIASDIGKIEVIKSDLNVVYSSLLVDNDIFNFFKSSFIDGHLRMRILKKIYADKIL EETFNLIAILVERDMINILFAIIVEYENLCNEYYNIIVVKITTASNMTDTEDMNKLKD HITNMISDKDIHFTFNIDENIIGGVVIEVEDVVYDYSVRRLLTELKSSISENN" gene 15110..16609 /gene="atpA" /locus_tag="atpA" /db_xref="2489152..2490651" CDS 15110..16609 /gene="atpA" /locus_tag="atpA" /product="F0F1-type ATP synthase, alpha subunit" /translation="MNIKASEIAAVLKEEIKNYKADFTPNEVGVVVEVGDGIARIIGL PHVMANEMILFESGAVGLAFNLEEETIGAIVLGDYYGIKEGSKVSRLKRILEVPVGDA LLGRVVNPLGVPIDGHGEITTDKRRVIEFPAPGIADRQAVKQPLQTGIKAIDSMTPIG RGQRQLIIGDRGTGKTSIALDAIINQKGTGVICIYVAIGQKASTVAGVVDTLRQHGAL EYTIVVAATAADSAPLQYIAPYGGCAMAEYFMYEQKKDTLIIYDDLTKQANAYRQISL LLRRPPGREAFPGDVFYLHSRLLERAAKLSDELGGGSLTALPIIETQDNEVSAYIPTN VISITDGQIYLLTSLFMSGVRPAIDVGISVSRVGGNAQTKAMKKVAGTLRLDLASYRS LEAFSQLGIGLDKATLAQLDRGAKMVELLKQKQYSPIPFEEQVVVIFAATKGFLDNIE VDRVHEFEWRLLQYMRADKQNILDDIREKKDIEDMDGLYKIIEEFKSKF" gene 16673..17551 /gene="atpG" /locus_tag="atpG" /db_xref="2490715..2491593" CDS 16673..17551 /gene="atpG" /locus_tag="atpG" /product="putative F0F1-type ATP synthase, gamma subunit" /translation="MAEKLNVLKARIKAVSSTHKITKTMDMIARSRTAKILTVEQGMR PFTQKLNRIVEDLSHSDMDHVHPLLAPKKKIKNIILFVVTSSRGLCGSYNTKIFDEAM ERIRHHHRHGREVQLHVLGKKGEVYFEKQGIPIARKYPRIDEESTFDDCATVVQRFMH EYAVDNASRVEVIYTRYYTRVVHIPKIKSLIPMIPDEEDIEGHKIKKKLDYVIEPNVD DVLKEVVPMAIKTYFYFMLTSSFLSENAERAIAMRNATDNAERLLTDLKNKANRARQE HITNELLDIIGGSEAI" ORIGIN 1 atgaataata ctgaagagct aatatacgat gacgatgata tgctgtcgcc tatagatgcg 61 gcgaaaatag ttggagtctc aagaactact gtgaattatt gggtaagaca ttatggatta 121 aaggctgatg ttacacccgg taagagatac aaaatccgtt atgctgattt aaaagctttt 181 ttggctttca acaaaaaaga aaaaagaatt aaattaaaaa gaaaacagtc taagtataaa 241 cttgccataa ttgaacctat ggaagttaca agaaagaatt atcttgaatg gctaaaagat 301 gattatgatg ttacatgcat atctaatttg gctgctcctt tgaaagaatt aaaaaagatt 361 tcacctgata ttattcttat ggatattaat ttatcagatg ataaagatta tttttatctt 421 atagatgaaa tcaaaaagga aatttcttta agaacatcat taattattat cataacaaag 481 agatataatg aagatgacgt tgtaaatggg cttgaaaaag gtgcttgtga ttatgtaaaa 541 aagcctgtag gacaaaatga acttaaagca agaattaaaa atgctattag attttatgtt 601 gatgtgtaaa taattttatt attaaagcat atttattgga tctatatcta tttctatata 661 atttcctttg tctgctgcaa aattagtatt tagtttgtta aagaagtttt ttagtaaaga 721 atgagacggc gtttttataa gaatattcca tctgtaatat ttatttaatt tactcatggc 781 acatgcggtt gctcctagga ttattatttt gtctgaatca ttataagttt ccattcggag 841 catatctgct attttatttg catcattttc cacttttttt tcatctattc cccttatcac 901 taatctaaca agtcttgaaa acggaggata atttaaaggt gcttttctat tttctatttc 961 tttattataa aaagatatgt aatcatgatt tttagcacat tctatactgt aattattagg 1021 tgaataggtt tgaatatata ctattccttt tttatctcct cttccgcttc ttcctgctac 1081 ttgagttatt aaattgaaag ttctttcagc acttctaaaa tcaggtatat gaagagacat 1141 atcagcaaaa agtactccaa ctaaagtaac attaggaaaa tcaagtcctt tagctatcat 1201 ctgcgtacca actaatatat ctatttctcc gtcagaaaat cttttgaata ttttttcata 1261 gttttttgtt cctccaacgg tatcctgatc cattctttct actacagcat ttggaaaaag 1321 tatatttaaa tgttcttcta ctttttcggt accgcttcct attctttcaa aatgtcctat 1381 tttacattca tcgcaaagct catctaaata ttgagtatat ccgcagtaat gacacataac 1441 aacatttttc tttttatgat aagtaagtga tacagaacaa ttggggcatt ccaaaactct 1501 ctgacaatat gaacagctaa caacaggggc atagccttta cgattaagaa atagtataat 1561 ttgttctttt ttttccaatt ttttatttat ttcttcaaca agtttttgag tgatcatagg 1621 aaaagcatca gctctttttt cctttttcaa atctaatatt ttaacctcag gcatattaac 1681 agaagctgct cttttcttta gacttagaag ttctattttt ccaattgaag catagtagaa 1741 actttctata gaaggagttg cacttcctaa aagtaatgtg gcattttcct gagattttct 1801 atagaaagca acctgtcttg catgatatct tggagtatcc cctgccttat agcttgtttc 1861 atgctcttca tctataacaa ttatacctaa attaggagta ggggagaata tagcgcttct 1921 agctcctata acaattttta tctcatcttt ttttatcatc tgccaatatc tgtatttaga 1981 attaggagat aatttgctat gaagtacagc tatttttcct tcaaatcttt cagcaaatct 2041 ttttatagtt tgaggtgtta aagatatttc tggaagtata actattgcct gctttcccat 2101 atcaacgact ttctttatag cttgaagata tacttctgtt ttaccgcttc ctgttactcc 2161 atgaaggaga aaagtttttg ggttatttga gtctatactt tcattaattt tttttaatac 2221 agcttcttgt tcttcattaa gttttaaata tggtttttgt tttgcaggta ttggtttagc 2281 ttttttttct ttttttgctg gagtacctac aggaagtgcg gcaaataatg cctctccgaa 2341 agatgaatga taataattac tcatccattt tgctaatttg aattctttat ctgaacaaat 2401 aggttcaaga tcaattctag ctttgatagg atatacttta tagttaccgt ctatagtttc 2461 aacttcttct acaacaatac ccttattatt ttttccctta ataggagcta caactctaca 2521 tcctaccaag ctatcattaa tctcatctgg ttttctgtat gtaagtattc tatctatagg 2581 cagattgaaa acaactttaa catacattat tacatttttt cgcgacgttt tttatcttca 2641 tatttagaca tgcagtttac acatcttaaa gtataaggca aagcagttaa tctttcttca 2701 ttgatttctt ctttacaatc aatacactta ccataagtgc cttcttctat tcttttaagc 2761 gcattattaa gcatatctaa tttgtctttt tctttttgag agaaattcat tagattttgt 2821 ttttcataag cttgaaatgc tatatcaacc atatcaccat gagaatcatc tttaagagct 2881 tcataagttt catttccgct taataattca tctaaagtct ttctcttttc ttctaataat 2941 aaatctttaa atttctttaa cttcttagca gtcattatac aaacctttaa gcaatagtaa 3001 cccaataaaa agatatctta acgttttgag aattggaaac gttttctagc accagatctt 3061 ccgtattttt tacgttcaac tacacgagaa tctctagtaa ggaatccatt tctttttaaa 3121 gtagttctga aatcctgact ttcacccact aaagccttag cgataccatg tctaactgca 3181 tcagcttgag cagaaacacc gccgccatga acattagcaa atacatcata ttttccaaaa 3241 ttacctgtta ctttcaaagc atcttctact actttaagaa gagctgctct attgcagaag 3301 tattcagcat aattttttcc atttattaaa attttgccgc tgcctaaagt tatacgaact 3361 cttgcattag ctgtttttct tttaccagta aaaatagtta attgtttaga tgccattttt 3421 atctcctaat tatatattta ctacagtagg tttattagct tcatgcggat gctcgcttcc 3481 tgcatatact tttaacttct taagatgaag tcttcctaat ggattatgag aaagcatacc 3541 ttttacagct atttttacca ttctttcagg atttttttct aataattcgc cgtagcttat 3601 agcttttata ccgcctggat aacctgtatg tctatagtga atttttcctt tctttttatt 3661 tcctgttaat actatgtctt tagcattgat gatgataaca taatcaccat tgtctaagtt 3721 gtatgcatag tctactttat gttttccttt aagcatataa gctgctctgc ttgctactct 3781 tcctaatgac ttacctttgg catcgattat tagccaattt tgctttatat ctttttgtga 3841 taaaacgtaa gtactgtttt ttgtttttaa tgttttttta tccataacat acacaccttg 3901 atttaacgtt ttaaaaaaat ttggtagttt taatcttaaa aatgtaacgg tgcgtaatta 3961 taacatgaat atattgtaaa gtcaaattta atttataaaa ttattctagc tatttgaaag 4021 cttgttttga tgcctattaa cttgattatt ctaacagatt tatttatccc tactattttt 4081 actacatcta taatattttt agatttaata actttaggta tattctttat tcctattatt 4141 tttatgatgc cttttaattt ttttatacca attattttta ctatttttga tatttttttc 4201 ataatattat ctcaatataa tatttctatt tcaaaggcat attatctaat aatcttgtcg 4261 atccgcagta gcatgatata agtattattg aatttcttgt tgctgtttct acattagcta 4321 aagtttcttt atctgctata taaatatatt ctaatttcag cattttatga gattttagat 4381 tattctttat tatatctatt aaatatgatg atttattacc gcctttttta aactcttctc 4441 ttgcctcttt tagaagttta tatattatag tagcttcttc tttttctctc tcacttaata 4501 aactatttaa actgcttaaa gctagcatat tctcatctct tactatagga atagttttta 4561 atgctatatt ataatttaaa tcttttatta ttttttttat tataaacatt tcctgataat 4621 catattctgt taaatataca taagtaggtg atattatatt gaatagtttt aatgttattg 4681 ttattattcc tctataatat ataggtcttg aaattatatt gaatttatta ttttctatat 4741 ttatatgcat agcataatca tcaggtatca tctcttcaac agatggtaaa aatagaacat 4801 ctacctgcaa ttctgacaaa agttttttat ccttatctaa atcctctgga tatttttcta 4861 tatcttccac ttttgtgaat tgaagaggat tgagaaatat acttacaatt acaatattac 4921 attctttttt tgcctttttt attaaagcgg catgtccttc atgtaaagct cccatagtag 4981 gtataagagc tatagtctta tccttattat cactaataaa tttatatgca ctttttatat 5041 tttttaatat agttaaagcc atatattaat ccattttttt attcatttta tcctgatttg 5101 tggcaggctc ataaaaatat aatgcgagta ttgtctgaag cggaaacatt ataatagctt 5161 caataaacat actgaatcgc ctaatagtga agataatatc ttttttaagt acgaatacat 5221 tcactatata aagtatctta ctggcagcaa atgctaagaa taataatatt attaaaaagt 5281 aaggcaatgt atttggtgcc ggtaatatag taatatattt aggtatttca tcgttattgc 5341 aattaactat aaaaagatat attccaaata agtatataaa agcaaatatt ccatctaata 5401 taatagaaat aagttcagca tttttatgtg aaatttcagg ataaagcaaa gttccgcatg 5461 atctgcattg tttagcatat ttatcattaa ctgttttgca agatttacat ttaatcgttt 5521 tagccatagt tcagaatagc tccttcgtta ttgtctacat tatcgtaact attgatttaa 5581 aaataatcat atttataaat ggtaaaattg tcaactatta taatatttaa aaatcatttt 5641 gtattatatt caattaaata ataataataa agctaataga agttttttat tttctattag 5701 ctttattaat tattttaagt acaagttata tattaatgtc ctgcagtagt tatagtagta 5761 gtaatttcct ctgaaggatt ttttgtagga ggtattttta taagtcttaa gtcaaacata 5821 atcataaaca tacaaggtaa gaatatgagt gtaagcaaag aagcaaataa aagtccataa 5881 gctaatgcca taactatagg aataatgata tcagctctac cgcctatacc ataaacagta 5941 ggtaaaagtc ctacaactgt agtaacagta gttaagaata ccggacgaag tctttgctta 6001 gctccgtcaa caatagcctt agcaacgcct tttttacctc cttcaacacc ttcatctatg 6061 attttgttaa tcaagtcaac aagtataata ccattgttta caacaacacc tgccaaaccg 6121 atgataccta caacacccat gaatgataaa ggcattttgt gaatagcgaa tcctaataat 6181 acaccaatca aaccgaatgg aataattatc attatcataa taggctgtat gaatctgttt 6241 aactgaagca ataatacaat gtatacaaat atgaatgcca tagcaaaact gaataataat 6301 tgttttatag ctttcatagt ttctttagct tcaccgccga actctaattt taagcctctg 6361 tattctttat tgaaatcttt aaatctttca cttactgctg ccataacctg ctgagaagta 6421 ttttttccat attctatacc agctgtaata gttattgttc tttctccatt atagtgtttt 6481 aatgttgaaa gaccattagc tttttctact gaggcaatgt ttttaagata tattaatctt 6541 ccttgagagt taggtattaa aagatcattt aaatatttag catcataagt aaactgatca 6601 tcaaatacta ctctgaaatc taatttattt tcaagttcct gtatatatgt agcttcagta 6661 ccataatatg ctgttcttac ttcattagct acatttgcta cgctaactcc aagttctgct 6721 attttattat aatcaagcat aactcttaat tcttctttac ctattttatc atcatcatca 6781 atatctataa ctccaggaac agtagctaaa aatgccttga tttcatcttt agctttttta 6841 gcaagttcag tgtcatttcc tactatttta atatctacag gatcaccagg gtcaacagaa 6901 cctttagtat tcatcataaa tataggaact gtctgtctta tatctgtttt atctatttcc 6961 tgatttatta aagcaacaag ctcatcagct gttctagttc tttcagcagc aggaactaaa 7021 taaaccataa tacctgccaa acttcctttt tcttcagaaa ctatttcttg gtcaacctgc 7081 ttacctacaa gagagtataa agcaataagt tcttcaggtt ttactacttt agaaacagca 7141 tcttctattt tagcaatctg ctgagttgta acttcttttg tagtacctgt aggcatttct 7201 atattgataa ctatagtatc agcacttgta tcgtatataa gtacgaagtt tttgaaactg 7261 ttttgtgcta agaatataga agctataaac ataagtatga aaaatcctat aactatatat 7321 cttacatgta ttaatttctc taatattgca ccgaaaggta ttttcatttt atcgaataaa 7381 gcatctttat cgaaatcaag aggattttta aatttacttt tctttttagg tttataagat 7441 ttatatttat cttctttatc ctgcaattgg ttaggaagta ttaatactgc ctgaagcata 7501 ctaacaacaa gtgtaaatat aacgattctt gggaaaaggt ttaatatttt acccattata 7561 ccgctgattg taagcatagg gaagaatgca gcaacagttg taagtgttga agcaagcata 7621 ggcattacaa catcggaaac ggcgagcctt gtagcttcaa gtcctttata tcctgcctgt 7681 ttaaagttga atatattttc agatactacg atagagttgt ctactatcat accaagtacc 7741 gtaataatag cagctaatga cattgtattg aatgttattc ctgctacctg catatatata 7801 aaacatgcaa acatagtgag tatcataccc aaacttgtga acatagcact tttgaaatcc 7861 aagaatataa tcaaagttat aaagatgatt ataaatcctt gaataaggtt tgaagttaca 7921 atacttaaaa gtgatttaat agttcttgat ttatcaccca taacggatac ttgaatatta 7981 tcaggaacta tatcagcatt ttcagctaaa tattgattca ctacatcaat agttttaaga 8041 atgtcagcat tttcattttt tacaactgac aaagaataac cagctgctct gtttactctc 8101 atgtatacag ttttatcttc aaaacctgat ttaacatttg ctatatcatt aattcttact 8161 ctctgtccat tgaatgtaga acgaattata acattacttg cttccatagg atcttggaat 8221 tcaccgtaag ttacaacagt ttgttccttt ccgcctgttt ctatgtcacc gcctgtagct 8281 cttatgtttc ttatgctaag tgcattaaca acatcgctta aagctatata gttttgctgc 8341 atttttatag gatcaacata cactttaatt tcagggtctg ttcttccatc aactcttatt 8401 tcagatacgc cttcaagtct tacaagttca ttttcaagtc tttggctgaa atcaaataat 8461 tctctttcat caccttccat accttctttg aagtgtacag ctaaagtgta tatatccatt 8521 ttattagggt ttaagtcata agttgtaact tcttcaacat cttctgataa atccggaaca 8581 ttctgcattt gtctgaatat ttcgtcttta acaggctgtc tatttggtat agtttcatct 8641 agttttacta aaataattgc ggcattttca ataattgttg tattatattc atctataccg 8701 gatattccct gtaattcttc ttctataggt ataacagcat tttgttctac gtcaagcgga 8761 gtagcaccgg gatatactac agatattaac atcatatcca aatctgtaga tggaattgat 8821 tcttttctta ggttaaagta gtagtagcct cctacaaata atatggccat tactattata 8881 tttacaagca tcgttttttt ggcaaaaaat actataattc tttccatata ttgcttaatc 8941 tcctcttttt tatatgtatt aatgtaaata aagattttgt tattagaggg gttaattttt 9001 tattaattaa ccccctaata aatattttta tccctctaaa atccttattg aaagttgcta 9061 attaaaaaat tatttatttt attcataatc tatggcaagc aaagctctgt aatcaaatat 9121 agtcgttata aattcgtact gaagattcaa aagctctgtc tgagtagcta caagttccaa 9181 ccttgatgta agtaaatcat cgatttctaa acgtccttga tcaagttttt gaagctgagt 9241 agctattctt gaattaattg ctcttatctg catttgtttg cttgctatta aatttttgta 9301 agcattaaat ttagaaatat atgtctgtaa ttgagtatta aaatcttttt ctaattgatc 9361 atattgagct attattccat ataatgagtt ttcagccatt tgatattgtg ctttatttgc 9421 tctgtttcct aatggataag agaactgcac tccggcaaag aaatcaacat ttgtcatact 9481 gccgaaagat ttaaaatatc cttcagtatt aggactaaga ccattaagac ttacacttcc 9541 tacaaagtct aaattaggta atgtaccgtt tttcatagca tcaagagtat attcagctct 9601 tattttagat tgatatgcta tttgtccgtt tatactatca gcgaaaggaa ctgcctccat 9661 ctgcatattg cttcctaaat ctaaataagc atcccaagta gtatgatccg gctttatatt 9721 agttacaggc ataaagaaac ttacagttgc taaaagacta tctaagtaaa cctgattttg 9781 tgcataataa tcactgtaaa ccatagtttg tgttcttgcg ttctgataag agtcattatc 9841 tataagtccg ttattgtatc tgtctctcat ctgattttca aatcttttag cagttatata 9901 catgtttctg taataagcaa gaagtttttc gtacattatc cattgataat aaattttctg 9961 atatgaaaca ataacgctgg catcatctaa ttttctttga agcttagcta tagcaagagc 10021 atattcagca tcttttatag gatatttatc taaagtaccg aaaaaatttc ttaaaagagg 10081 ctgagttact tctaatgtta atgaaggctg ataattatta aaatctacag actgacctcc 10141 aggcatattt aatttaccgc ctaaaaaaga agtatgagtt aaattaacag accatttagt 10201 tcctgtataa ggtattaaag aacctagtcc aattccagcc tgtattcctg cggcattgac 10261 acttgggcta gctgtagtac tagtgtatcc gcttgataaa cttccgtatt tacctactgc 10321 tccaaactgt gcagataaat ttacatctcc tgaactttca gcactaagta aattcatctg 10381 agcattagtt tctgttacag catttatttt tagttctggt atttgatctc ttatagtttc 10441 catataagca gcataagtca aagtatttgt ttgaccatat aaaatattta taaatacaat 10501 agaacataaa attattttaa cacttatttt catttactct ccttatcgca tcaaatcata 10561 gaatattagc tcttattatt taattcattt gataaaaaat attaattttt aaagctgtat 10621 ttgtgtatgt ttttacttcc aagcaaaagc agcaatgttt tatataatgt gtcaattaaa 10681 ttatccaaat tcacatctaa tgttcttcct gcttctccat ggtatatatt ttcttcatct 10741 cctttgtaat agtatagctt tctgtctagg ttataatatt tatttaatat taattcgttt 10801 cctattcctg atgctgccac tatcatctgc atataaatgt cttgaggatc tattaccgga 10861 ttgaaatatt tttcatcaat tttcttatct atgaatatta acagttctga aaaccaataa 10921 tttaatacaa ggtctttatt tatattatct ttcaatttct gcattctttc tttactgtta 10981 aaaaacatag cctgcaattc aaacattatc tttccaaatt ccttggctgt tataaagaaa 11041 aattttctaa aagcatcgaa taattcaaat atagcttttt caggttcatc ataataattt 11101 tctataatat ctctaggatt tacttcagtt ttattgctgt taatcaatgc tattacaatt 11161 tcatctatat ttgaataata tttgtaaaca cctccttgac ttaaacctga ctctttaaca 11221 atatctttca ttcttacact atatgcaggc ttcttaaaaa atacactcat agctgcatct 11281 agtattatct tccttttgtt ctcaaaatat tcttgattta ctttaggcat tgtattattt 11341 tggtgttcac ctcgtacttg aaaaattaat atgaaaataa aaacgatact agtgtcattt 11401 ttatttgtga aatacatatt attacaatta ttttttattg tcaatatatt ttgtatagga 11461 aatttacgat ttttatacac aatttgttaa actcaatcaa aaaaacagct atatacaaca 11521 tttgctacat aaaatatttg taattaacta ttgtaaatat ttatatttag ttataaaatt 11581 agaacataaa atgacttcaa tattttttta atggagtttt attatcatgg aagtaaatat 11641 caaagagtta gagaataaca ctgtaatatt gaaattggat ggagatattg atgtttatac 11701 ctcatctgat ttaaaagatt ctattttttc acaaatagaa cttggagcaa aaaaaataat 11761 aatagatatg gaagatgtct attatataga tagtagtgga ataggggtat ttatttcggc 11821 acttggtaca tttaagaagg taaatggtaa aatatgcttt gtaaaagtta cagatcctgt 11881 taaaaaggtg tttgaactta ctaaaattaa tagttttttc cctgtattta caacagaaac 11941 tgaagctttg gctaattttt aatttatttt gaatttttaa tataaattaa atttagataa 12001 aataaaaaaa taagctgcaa taatagttga ttttttattt aatagttata aaattattac 12061 aatttataat aaatattttt atcattttta tgaaatttgt atacaaggta gtaattgttt 12121 attatgatta aagaattatt tttgcttagg aaagttttta tattaacttt aatattaagc 12181 tgtgtatttt ctgtcaatgt tctttacggt gctgaaacta ttaatgatta tataatggaa 12241 gagataactg ataatacttc ccatccattc tatacaattc ctataaaatt tggaaaatac 12301 attgattttg attttaaaat aacaaaacat ataatattgg taactttagc gggtatttta 12361 tctgtatgca gtatgaaata tttagctcat aaacttaaac gtcctttaaa tagacctaca 12421 tatttacaaa gtatattaga aggtttgata gattatatga ataaggatgt tatcggtgct 12481 actttaggag aagagggtaa gaaatatgta cctttttgtc ttacagtatt tttattcgta 12541 ttattttcaa atatattagg acttataccg gcatccatta aatttcctac agaagacgga 12601 aatcattctt atatagcagg aggacttgga gctaatatag gattcactgc tgctatagct 12661 atagttgtat ttatagttta tattgttgct ggaataagaa aaaaaggcat aataaaatat 12721 tggacttctt tggtgcctaa aggtttgcct atacctttaa tacctataat atgggtatta 12781 gagtttatta cattattcaa cagagctttt gctcttgcga ttcgtttatt tgcaaacata 12841 acaggcgggc atataatgat gatagttata ccgtatttga tagtaatgtc tggtacatta 12901 ttagtttccc catttgcggt attattctta ggattcatat atgttcttga aatgtttgta 12961 gcagttttac aggcttatat attctcatta ttatcagcag tttatattgg aattgctatt 13021 agtgatgagc attaattata aataaaatta tcataaaagg agaataaaaa aatggaactt 13081 tctatattag gtgcagcaat tggagcagga cttgcagcta taggggttgg tttaggaata 13141 ggttttatag gttctagagc agtagaagga atagctagac agcctgaagt atcaggtaaa 13201 atacaaacag caatgcttat agcagcagca ttaatagaag gtgttggact ttttgctttg 13261 gttatttgta ttcttgcact gttcacaaaa taatacagat agtaaataat tgatttggag 13321 gtatatgtat ggcactttta aaaatagatc ctggtattat aatctggact tggatcacat 13381 ttttactagt tcttgctata ttaggtgctt ctacttggaa aataattttg aagggtttga 13441 atgctcgtgc tgacaagata caagaagatt tggaagaggc tgagaaaact agagaaaatg 13501 ctaaaaaatc tttggcagca tatagagagc aaattgataa tgctaaggtt gaagctagtg 13561 ctattataga aaatgccaga gttgaggcta ataggattag agataaaatt attaataatg 13621 ctagagagga agcagaactt aataaaaaca aaattatgtc tgaaatagac agatctaaag 13681 aagaggctat gaatagtgta aaaaaacagg cacttgatat tgctgttgtt atggcagaaa 13741 ctattcttaa gagaaacatt aataaagaag ataatcaggc tttgattaat gaatttatta 13801 ataatgcaaa taaagaaaac agtcagaaat gatgatattt aagaattttt aggaagtaaa 13861 ttaatcttat gaaagaaagt gataagctgc aaatattaaa acctacagct agtgctatat 13921 ttgatatagc tagagagctt ggaatgataa aagaaatata taatgaactt tcagaatgtt 13981 caaaattatt tcaggatatt gatataaaaa aatatttttt tgataaatca atttctaaaa 14041 aagataaaaa agaattaata gataaaagat taaaaccaat actttctaaa gaaacttatg 14101 cttttgtatc tatattaaca gaacatgata gtatagatgt tctgccggat attgttgctt 14161 tgtataaaga gatagctgat gattatagta atatagtcag agttcgtatt attacagcaa 14221 gtactattga tgataaaaca gtagaagata ttattcaaac agttaaatgt ttttccagca 14281 atgaaatatc ctatgaaact atagttgatg aaaatattat aggcggaata atagtatata 14341 ttggctctgt agtttatgat tatagtataa aaaaacaaat agatttattg caaagtaaat 14401 ttacctatgg taattaatta aacattatag gagttgtata atatggatcc tattgctgaa 14461 aacattttaa gtgatctcaa gaaagaagtt cttagagagg ttacaagaga aaaggcaagt 14521 agatttagcc gtattgtaaa aaatgaatct agtgccaaaa attatgcaaa ggctatgttt 14581 gatattgctt cagatatagg taaaatagag gtaattaaaa gcgatttgaa tgttgtttat 14641 tcatctttgc ttgttgataa tgatatattt aattttttta aatctagttt catagacgga 14701 catttaagaa tgcgtatatt aaaaaaaata tatgcagata agattttaga agaaacattt 14761 aatcttattg ctatcttagt agaaagagat atgattaata ttttatttgc aataatagta 14821 gagtatgaaa acttatgcaa tgaatattat aatataattg tagtgaaaat tacaactgca 14881 tcaaatatga cagatacaga agatatgaat aaacttaaag atcatattac gaatatgata 14941 tcagataaag acatacattt tacatttaat atagatgaaa atataatagg cggtgtggta 15001 atagaggtag aagatgttgt atatgactat agtgtaagaa gactgcttac cgaattgaaa 15061 tcttctattt ctgaaaataa ttgatacatt ttatatttga ggaattgctt atgaatataa 15121 aagctagtga aattgcagcg gttcttaaag aggagattaa gaattataaa gctgatttta 15181 ctcctaatga agttggagtg gttgtagagg ttggagatgg tatagctaga atcattgggc 15241 ttccacatgt tatggctaat gaaatgatac tttttgaaag cggtgctgtt ggtcttgctt 15301 ttaacttgga agaagaaact attggtgcta tagttctagg tgattattac ggaattaaag 15361 aaggaagtaa agtaagcagg cttaaaagaa tattagaagt acctgtagga gatgcattac 15421 ttggaagagt tgttaatcct ttgggtgtac ctatagacgg acatggtgag ataactactg 15481 ataaaaggag agtaatagaa tttcctgcac caggtattgc tgacagacaa gcagtaaaac 15541 agcctcttca aacaggtatt aaagctattg actctatgac tcctatagga agaggtcaaa 15601 gacagcttat catcggcgac agaggtacag gtaaaacttc cattgctctt gatgctataa 15661 ttaatcaaaa aggtacaggc gttatatgta tttatgtagc aataggacag aaggcttcta 15721 cagttgccgg cgttgttgat acattaagac agcatggagc attagaatat actatagtag 15781 ttgctgcaac tgctgctgat tctgctccgc ttcaatacat agctccttat ggcggatgtg 15841 ctatggcaga atattttatg tatgaacaga aaaaagatac attgattata tatgatgact 15901 taactaagca ggctaatgct tacagacaga tatcattact tttaagaaga cctcctggaa 15961 gagaagcttt tccgggcgat gtattctact tgcattcaag acttcttgaa agagctgcaa 16021 aacttagtga tgaattggga ggcggttctt taacagctct tcctataata gaaactcagg 16081 ataatgaggt atctgcttat attcctacta acgttatttc tattactgac ggacagatat 16141 atttgcttac tagtttattt atgagcggtg ttcgtccggc aattgatgta ggtatatcag 16201 tttcccgtgt aggcggtaat gctcagacta aagctatgaa aaaggttgct ggtactttaa 16261 gacttgacct tgcttcttac agatctttag aggcattctc tcagcttggt attggacttg 16321 ataaagctac tttggcacaa ttagacagag gtgctaaaat ggttgaatta ttaaaacaaa 16381 aacaatacag tcctatacct tttgaagaac aggtagttgt tatatttgct gctactaaag 16441 gtttcttgga taatattgaa gttgacagag ttcatgaatt tgagtggaga cttcttcaat 16501 atatgagagc tgataagcag aatatacttg atgatattag agagaaaaaa gatatagaag 16561 atatggacgg actttataaa atcatagaag agttcaaatc taagttctaa tttttatatt 16621 atatgattat ataaattagt cttggcaatt ctattgattt ggggtttttt attatggcag 16681 agaaacttaa tgtattaaaa gcgagaatta aagctgtatc aagtacgcat aaaataacca 16741 aaactatgga tatgatagcg agatcaagaa cagctaaaat tctaacagta gaacaaggta 16801 tgcgtccttt cactcaaaag ttaaacagga tagttgaaga tctttcgcat tctgatatgg 16861 atcatgtgca tcctttgctt gctccaaaaa agaaaataaa aaacataata ctttttgttg 16921 taacttcttc aagaggatta tgcggttctt ataatacaaa gatttttgat gaggctatgg 16981 agagaatcag acaccatcat agacatggaa gagaggttca gcttcatgta ctcggaaaga 17041 aaggtgaagt ttattttgag aagcagggca tacctatagc acgtaaatat cctcgtatag 17101 atgaagaatc tacttttgat gattgtgcta ctgtagttca gcgtttcatg catgaatatg 17161 cagttgataa tgcttctagg gtagaggtta tatatacaag atattataca agggtggtac 17221 atatacctaa aattaaaagt ttgatcccta tgattcctga tgaagaggat atcgagggac 17281 ataaaataaa gaaaaaatta gattatgtta ttgagcctaa tgtagatgat gtattaaaag 17341 aggttgtacc tatggctatt aaaacatatt tctattttat gcttacaagt tcttttttgt 17401 ctgagaatgc tgaaagagct attgctatga gaaatgctac tgacaatgct gaaagattat 17461 taactgatct taaaaataaa gctaacagag caagacaaga acatattact aatgagcttc 17521 ttgatattat aggcggttct gaggctatat aatttatttt gtatataaaa aattaaatac 17581 cattcattat ttattttatg gatggtattt ttttatttta aattttttaa tttttgtaca 17641 ataatgagta atcagccgca cactttacag tgcttccttc gttcgcgtat aaatgactat 17701 tataatatta tgatattgcc actacggcta gtatctgaca aagttaaaaa tttttagtat 17761 atactaaaaa ttttatagtt tgtatttttt tagtcaactt tttcccgaca cttacgctct 17821 gcgggcttcg ccaaagttga tgccaacacc acaggtggac ttcgtaggca tgctttgaga 17881 aagtgcaagt ataaaattag tactaaatca tactaaaatc gtcttacatt taaaataatt 17941 tattatattt aagtttaaat atatactttc gcgaagcgta tccgagcctg tcgaggatat 18001 atacctaaag atacttcctt cggtcgcaaa agaagtgggt ggcggcactc tgtgtact //