LOCUS NC_012225:19 19132 bp DNA linear BCT 26-AUG-2011 DEFINITION Brachyspira hyodysenteriae WA1, complete genome. ACCESSION NC_012225 SOURCE Brachyspira hyodysenteriae WA1, complete genome. COMMENT locus start: 1775264; locus end: 1794395 FEATURES Location/Qualifiers source 1..19132 /organism="Brachyspira hyodysenteriae WA1, complete genome." gene complement(0..1874) /gene="" /locus_tag="" /db_xref="1775264..1777138" CDS complement(0..1874) /gene="" /locus_tag="" /product="putative inner membrane protein" /translation="MSNNKRMVIAIGLSAIIMFLYMFYQAKTMKPVYNSNVSTNSNAV SNNNNITSENILLNTAQMQKIEKIENTNAVINDNEKILENEYVIATFKNGSLYSYKLK NYYPQDLGADATNEIIDMVEQVYEGIYPFTVTFQNLSNSIAIPENLDYQLIEESGDKV SYSANAIIDNTEVKITKTFTFGEDPYQLKNSVNIENVGEKDLSLFYSYFLATGIGPYR TDKNAIREDATKAQYLIKGNGKSKILLTGDIVKDNIFSRLFGFGNSSKGIKTNQMRYA IYEGEDKWVALNNRYFAIISSPAQSNNTVFETMTFSKPSTNEYRNDFHVANLMSKHTI KSGSSITDNYSVFMGPKVRRTFSKYYLEESYESIFQESFLGLNLRPLTYILDVILNAL YNITKNYAWAILLFTFLFKLVTFPLNHASYKSMKKMQLVNPKIERIREQYKDNPDKLN AEIMAIYKKEKINPLGGCLPMLLPFPLLIAFFYLMQSMVELRNTPFLWITDLSSPDKL FVFPAGIPILGGFNFNLFPIVMALTSYLSMKLQPSSSAGNSSAAAQMKMMTTIFPLMM LLMFYNFASGLALYWTAQNIFGVAQQFITSKIDKSNTNEIVEEEETKQIGKKKKRKKR" gene complement(1964..2143) /gene="" /locus_tag="" /db_xref="1777228..1777407" CDS complement(1964..2143) /gene="" /locus_tag="" /product="hypothetical protein" /translation="LYQKAISPYLRPSCRYIPSCSEYAKQAVIKYGAIKGSFLAIARV LRCNPLAKKIYDPVP" gene complement(2170..2349) /gene="" /locus_tag="" /db_xref="1777434..1777613" CDS complement(2170..2349) /gene="" /locus_tag="" /product="ribonuclease P protein component" /translation="VGRNRAKRIVREIYRTQKDKIPTGYDYFIIVNRFDSYKLPSFDD YKRDLLKLFQKVLYI" gene 2930..3409 /gene="" /locus_tag="" /db_xref="1778194..1778673" CDS 2930..3409 /gene="" /locus_tag="" /product="response regulator" /translation="MKKYLLENKLEDITPLIENLSTEVKKYIPSNEMDLFAAALYEVI MNAIEHGNLNILYETKKNWLKKNIYHKKLKELLKTEKAKSTNVEITLQIEEDNITIAV KDQGLGFKPKQEAKKINNDGFARESGRGIMMIKSYFDEVKFNKKGNVITLTKLIKKE" gene 3516..5066 /gene="" /locus_tag="" /db_xref="1778780..1780330" CDS 3516..5066 /gene="" /locus_tag="" /product="histidine kinase" /translation="MSNDKKTKKVKNTKYFRKSPPIQLDTGFVSLERFMAINEYDDGS FSREYNCDIINRKGRDAVIIVPYTYIDNQIHVLMISTFRPVVYYREKVMTGKRPEEID EHTMNFLEFPAGMLEEDEINEKNPNQGIKKCAKRELEEETGYSVDLKKINVLGHKYYS SSGIITERINIATCDITGLTPKKEIQTDGSVMEETIESFFVPFDKAMRWCKEGVIKNA GTEIGLHRLYFSILYEHQKNHNLILQKRLHTLLNEINSLKKSAEHYNKLIREFKATVS HELRHPFTEIMGYINLLKKNNMPEEKREEFFNIVSRSIKKLYDTNNNLIQIALKDDES SKYVSEFNIKEELDIIIDGYKFIYPKNINIEMNIEKNCTTLIGYHERFRLIMEGIISN AFKFTKSGTISINVRPLDTIEKKELDFSPDLFNYHTMKNIIPNEIEIIVKDTGKGIKP SKLKKVFIPFYQADSRFEREYGGMGIGLSVVKDLLDTMQGTINIDSSEGAGTIVKLRM PFGIPSKN" gene complement(5599..6030) /gene="" /locus_tag="" /db_xref="1780863..1781294" CDS complement(5599..6030) /gene="" /locus_tag="" /product="putative anti-sigma factor" /translation="MSIEYCGNKVEKILSVKIPSNKLLVPKVSNDFFDFLHSNQIEGC DAFRVAFEEALTNAIVHGNKNDYNKNVSIDFYINDEIIKVAIEDEGDGFDYFSAMICL TESQDNIYKDSGRGIFLISLYTDDFYFEDNGRKIIIKKNRN" gene 6217..7323 /gene="" /locus_tag="" /db_xref="1781481..1782587" CDS 6217..7323 /gene="" /locus_tag="" /product="aminotransferase" /translation="MNLYRGYEKRKEAIDKKISSIIERSQFIFGEELESLEKELSNYT GAKYAVGVSSGHVGLVLALLALGFNAGEDHSQKEVIVPAMTFFSTAEAPAFLGMKVRV CDIDEYFNMDVKKLESLINKNTVAIIPVNLFGQCANYDVILDIAKKHNIFVIEDACQS FGASYKNIKSCSGKLGDIAVTSFFPAKPLGCFGDGGMVFTNNEELYKNLKQLRHHGDE GGMIHVKLGTTGRLDNLQAGILLEKFKGFDADMDHRRSAAEYYNEKLKDVVKVPQVAE YTQSVHAQYVIQVENNRDEVRTKLNELGIPTALYYPHPIHLAPILVKKLGYKEGDMPV SEYASKHNLALPIDNDILKEEQDMVIDAVKKVIK" gene 7539..8192 /gene="deoC" /locus_tag="deoC" /db_xref="1782803..1783456" CDS 7539..8192 /gene="deoC" /locus_tag="deoC" /product="Deoxyribose-phosphate aldolase" /translation="MNNLNKLIDHTILRPDATIDEIRKLCIEAKEYGFYSVCVNSAYV NVAYNFLLHSDVKVCSVVGFPLGAMMKEAKAYETKVAVDSGADEIDMVVNVGFLKSKK IDLFERDIKKVRDACHASVLKVIIETCLLTDEEKVLACKIAKECGANFVKTSTGFSTG GATEHDVKLMREAVGKEMGVKASGGIKTYEDAIKMVEAGANRLGTSSGIAIMKSALN" gene 8206..9024 /gene="udp" /locus_tag="udp" /db_xref="1783470..1784288" CDS 8206..9024 /gene="udp" /locus_tag="udp" /product="uridine phosphorylase" /translation="MEYKEPKAFYDEEAFKNDLLQYHIKLKKGDVARYVLLPGDPKRV GYIAKFLDNPELKADYREYVTVTGKYKGVDVSVTSTGIGGPSASIAMEELIKVGADTF IRVGTAGGLSLKVKPNDLAIAQAAIKDEGTTKEYIPLEYPAIANTDVMLALRDAAKKI NANYHIGVVHSKDCFYGELEPQNSFFREKFENNLKYYTLCGAIASEMECAALFACASL RKVRAGGIMHIVENTMVERMGTHLEYSDNIENMILTALEAIILLNEKDKKAEKK" gene 9043..9828 /gene="" /locus_tag="" /db_xref="1784307..1785092" CDS 9043..9828 /gene="" /locus_tag="" /product="uridine phosphorylase" /translation="MFPKAYYQENENLVHHLKLKKGDVGRYVIMPGDPKRCVKIAKRF DNAKLISDYREYATYTGYINGVKVSATSHGIGGPSTAIALEELIKVGADTFIRVGTCG GMNMEVLPGDVVIVNGAIKGGGTMDNYIPKEFPCVPNIDVLEAMIEGADKIKTRTHVG VVQCKDAFYAQHAPESMAVDNELLYKWDSYIKAGCLASEMESATLFAVGAAKNVRTGA AMLVLHNQERVKNNINDPKNYTGEEAIDLIIESIKILIDKDKK" gene 9883..10941 /gene="" /locus_tag="" /db_xref="1785147..1786205" CDS 9883..10941 /gene="" /locus_tag="" /product="basic membrane lipoprotein" /translation="VLFITSLFALSCSKSPNTNTSTFEIAVLIDLGPIDDKSFNQGSW EGVKDYAENYGISYKYYRVPDKDIDSYLNTIDLAVKCGAKLIVTPGYMFEPAIYKAQD IYTNVNFILIDGEPQDGTYTDYKTSPNTVAILYSEEEAGFLAGYAIVKEGYTNLGFMG GVAHPAVVRFGYGFVQGADYAAVESKLPKDSVNIKYTYIGNYDPTPENQTLATSWYKS GVQVIFAAAGAAGNSVMSAAENNNGLVIGVDVDQSFESPTVITSAMKLIRESVYNAVA SYYNGNFSGGKTTILGAQVKGIGLPMSTSKFKVFTESDYNIIYDSLVTKTIKVLKDTD IENVNNLHLNSAKVNYIK" gene 10988..12061 /gene="" /locus_tag="" /db_xref="1786252..1787325" CDS 10988..12061 /gene="" /locus_tag="" /product="basic membrane lipoprotein" /translation="MKKLLTLLIVFVFLYTVSCSNTNSGKSLGYEIAVIMRNIDDKSF NQSTWRGVKDYAEHYGISYKYYKVPDKNVQSTLNAIDIAVRMGAKLIVTPGSIFEPAI YKAQDIYTNVHFILIDGKPQDGTYTDYKTAKNTIAILYAEEEAGFLAGYAIVKEGYTN LGVIGGMALPPVIKFGYGFVQGAEFAADELKIPKDSINIKYTYVGNYDDSQENQNLAA SWYKSGTQVIFAPAGGASYSVINAAENNGGLVVGIDVDQSFESPTVITSSMKLIRESV YNAVAAYYNGNFNGGKTFILDTRVNGVGLPMSTSKFKVFKEYDYNIIYNSLMRKKIRV LKDTDAESVDKLPLNLVKINYIN" gene 12096..13148 /gene="" /locus_tag="" /db_xref="1787360..1788412" CDS 12096..13148 /gene="" /locus_tag="" /product="basic membrane lipoprotein" /translation="MIIITAFILMISCSKTEQVGEFDIALITEGKIDDKSYNQGAWEG LIRYAESTGKKYKYYQAAENNTEAYIDAIDSAVSEGVKLIITPNYLFETAVYKSQDKH PDVNFIIIDGVPQDGTYTDFRIEKNVHAMIYAEEEAGFLAGYAIVKEGYTNLGVIGGM PVPPVIRFGYGFVQGANYAAKELNMPTRSIKINYTYIGNFSDTGENKELASSWYQNGV QVIFAPAGGAGKSVISSAEENNGLVIGVDVDQSFESPVIITSAIKRIRNSVYNAVDSF YNGTFKGGQTTILDAKVNGIGLPIKTSQFKNFTENDYNAIYNQLSEGNINILKERNAR TVEELPLDIVEINYIK" gene 13256..14284 /gene="" /locus_tag="" /db_xref="1788520..1789548" CDS 13256..14284 /gene="" /locus_tag="" /product="basic membrane lipoprotein" /translation="MISCGGGKKSGGYELALITDVGTIDDRSFNQGSWEGLTKYAQEK GISHKYYQPSQKTTDAYVDAIDLAVSAGAKLVVTPGFLFEPAVYRAQDTHPNVSFVLL DGTPQDGTYTDFRIEKNVYSVLYAEEQAGFLAGYAIVKEGYTNLGVMAGMAVPAVIRF GYGFIQGANYAAKEMNMPVGSIKINYTYIGNFNATPENQTLATSWYQSGVQVIFAPAG GAGNSVMSAAEQNNGLVIGVDIDQSAESPTVITSAMKMLGESVYNAIDDFYKNQFPGG KSVILDAKVNGIGLPMSTSKFQKFTQNDYDAIYQKLNNSEVKVLTDKDAKDVNQLPLD IVTVNLIQ" gene 14445..15974 /gene="" /locus_tag="" /db_xref="1789709..1791238" CDS 14445..15974 /gene="" /locus_tag="" /product="ABC transporter related" /translation="MENSEYVVEMLNITKRFKGIIANDNITIQLKRGEIHALLGENGA GKSTLMSVLFGLYKQEEGIIKVNGKEVNIDNPNTANALGIGMVHQHFKLVHNFTALEN IMLGVETVKNGILQVDDARKKVMELSKTYGLEIYPDSLISDLTVGMQQRVEILKMLYK DNNILIFDEPTAVLTPSEIEELMKIMKSLTKEGKSILFITHKLNEIKEVADRCSVLRK GKYIGTIDVKSTTKEEMSEMMVGRKVSLVVDKTEAKPKDIILSVKDLNVKSPHSEKNI VKNVSFDVRAGEIVCIAGIDGNGQSELIYALTGLIDMSSGSIHLNGKDITNLSIRNKT LSGIGHIPEDRHKHGLVLDYTLGENTILQTYFTERFQNKGFLKFKEIENYANELIKRF DIRSAEGAKTIARSMSGGNQQKAIIAREIDRNPDLLIAVQPTRGLDVGAIEYIHKELI RQRDNGKAVLLVSLELDEVMNLSDRILVIYEGEIVANVNNKDLTINELGLYMAGSKRS A" gene 16032..16892 /gene="" /locus_tag="" /db_xref="1791296..1792156" CDS 16032..16892 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MRNINRMNDYFVRYLLGSIGNEDILENIVNCVLIDSGFEEVHNL EIINPHNLPENINLKESVLDVKAITKDNKKIIIEIQLSGNIDFVKRIYYYISKNIVSE LNENESYDIISQVISINFVNFNMDFNDEGKEHRCFKLIDTQNHNVSLDIIQMHIIEIP RFTKILNNSSIDDIKKNKILSWIEFFTVKDLDKVKEKLKELNNIMPKVIDKYERFISS EEEMEVYNARDAFLYGQTIMLKREREEGIKEGIEKEKYSLVRNMKKKNMDINLISELT GLSIEEIEKL" gene 17031..18146 /gene="" /locus_tag="" /db_xref="1792295..1793410" CDS 17031..18146 /gene="" /locus_tag="" /product="inner-membrane-translocator" /translation="MDLKNKLAGILEKEGFVNIFSSFLAIIIGLLLGLIILLISNVHD AFPAFMTILSGGFSGGSRGMGQVIYTATPLILTGLSVGFAFKNGLFNIGAPGQFIVGA YAAVLVAVKCTFLPPALHWFVALIVSFIAGGLWAYLPGFLKAHFNVNEVISSIMMNYI GMYLVNYLVTLTVYDMLKNQSQNIPPSSMIPTMGLNVIFRGSSANGGFFIAVIVVIIV YIILSKTTFGFELKACGLNKDASKYAGINEKRNIILSMVIAGALAGLGGGLLYLSGVG KHIEVVDILAEEGFMGIPIALLGLSHPIGILIAGLFIAHITVGGFYMQIYDFTPEIIE MIISSIIYFSAFALLFKSIVGFISKKLVKKEEKNANE" gene 18178..19131 /gene="" /locus_tag="" /db_xref="1793442..1794395" CDS 18178..19131 /gene="" /locus_tag="" /product="inner membrane translocator" /translation="METIYFLVQQTMFFSIPLLLVALGGMFSERSGVVNIALEGIMII GAFAGIFFISRLGANFPPMITLFLAMIISALSGLIFSLLHAYAAISMSADQVISGTAL NIFAPAFAIYVTRAIQTVQQISFVNNFRIESVPILGSIPIIGGLFFKNTYITTYIGFI ILALSWFTLYKTRFGLRLRSCGEHPQAADSVGINVYKMRYIGVAISGALGGLGGLVFV IPTSTNFNATVAGYGFLALAVLIFGQWKPMKILYAAFFFGLMKTLASAYSGIPILANL PISNNIYKMIPYITTIIVLAFTSKNSQAPKASGIPYDKSVR" ORIGIN 1 ttatctcttt tttctttttt tctttttacc tatctgtttt gtttcttctt cctcaactat 61 ttcattagta ttagatttat ctatctttga agttataaac tgctgagcaa ccccaaatat 121 attctgtgct gtccaatata aagcaagtcc gcttgcaaag ttatagaaca taagaagcat 181 cataagcggg aaaatagtag tcatcatctt catctgtgca gctgcactag aatttcctgc 241 tgaagacgaa ggctgcaatt tcatacttaa ataactagtc aatgccatca ctatagggaa 301 taagttaaaa ttaaaacctc ctaatatagg tatgcctgcc ggaaatacaa ataatttatc 361 aggagaagaa aggtctgtta tccataagaa tggagtattc cttaattcta ccatagactg 421 cataagatag aaaaatgcta ttaacaatgg aaatggcaat aacataggaa gacatccacc 481 taaaggatta atcttctctt ttttataaat agccattatc tcagcattta atttatcagg 541 attatcttta tattgttctc ttatgcgctc tattttagga ttaaccaatt gcatcttttt 601 catagattta taagaagcat gattgagcgg aaaagttaca agcttaaata agaatgtaaa 661 caacaatata gcccatgcat aattctttgt aatattatac agagcattaa gaataacatc 721 taatatataa gttaaaggtc ttaaattaag tcctaagaaa gattcttgga atatagattc 781 ataagattct tctaaataat acttagaaaa agttcttctt actttaggtc ccataaatac 841 tgaataatta tcagtaatag aagaaccgct tttaatagta tgtttagaca ttaaatttgc 901 tacatgaaaa tcatttctat attcattagt tgaaggctta gaaaaagtca tagtttcaaa 961 aacagtatta ttagattgtg caggagaaga aataatagca aaatatctat tattcaaagc 1021 tacccattta tcctcacctt catatatagc atatctcatc tgattagttt tgattccctt 1081 tgaagaatta ccaaatccaa ataatcttga gaaaatatta tcttttacta tatctcctgt 1141 taataatatt ttagatttac catttccttt tatcaaatat tgtgctttag tagcatcttc 1201 tcttatggca tttttatctg ttctgtatgg acctatacct gtagcgagaa aatatgaata 1261 aaatagagaa agatcttttt cacctacatt ttctatatta acagaatttt ttaactgata 1321 tggatcttca ccaaaagtaa aagttttagt tattttaact tctgtattat caataatagc 1381 attagcagaa tatgaaactt tatcgccgct ttcttctatt aattgataat ccaaattttc 1441 aggtattgct atagaatttg ataggttttg aaaagttaca gtaaaaggat aaataccttc 1501 ataaacctgc tccaccatat caataatttc attagtagca tctgccccta aatcctgcgg 1561 ataataattt tttaatttat atgaatacaa agaaccattt ttaaaagttg ctataacata 1621 ctcattttca agtatttttt cattatcatt tattacagca tttgtatttt ctatcttttc 1681 tattttttgc atttgagcag tattcaatag aatgttttca gaagttatat tattattatt 1741 actgacagca tttgaatttg tacttacatt agaattataa acaggcttca ttgtttttgc 1801 ctgatagaac atgtatagaa acattattat agcggaaagt ccaatagcta taaccattct 1861 tttattattg ctcataaaat gttaaagctc cttaaatcaa taatatacaa acaagaattc 1921 tttaagcaat taaaaaagga agatggtcta acatataaaa aatactatgg cacaggatca 1981 tatatttttt ttgctagggg gttacatctc agtactctgg caattgcaag aaaactaccc 2041 tttatagctc cgtatttaat gacagcctgt ttagcatatt cagaacatga aggtatatat 2101 ctgcaggaag gtcttaaata aggtgaaata gctttctgat acaaaaaaat caaaaacaaa 2161 agaatatttt tcatatatac aaaaccttct gaaataattt taataagtct cttttataat 2221 catcaaatga aggcagctta taactatcaa acctattaac tataataaaa taatcatatc 2281 cagtaggaat tttatctttt tgagttctat atatttctct aactatcctc ttagctctat 2341 ttctgcccac agaattagtt ttgtttcttt ttatagttac agcaaaccta gaatatgagc 2401 gattattttt taataagagc acagtgtatc tagaattata aattctttta acactgctgc 2461 tattattaaa gaatgctgat atatcgcttc tgtgctttaa ccgctcttta ctatataatt 2521 tcaatgagta ttccctgtaa cagttttcca taagtactgc ttaataattg cttaatattt 2581 tactcatctg ctgcagttaa acgatatcta ccttttcttc ttctgcgttt taaaacatca 2641 cgtccatgtt tagttgccat acgtttaaaa aatccgaatt ttctagcacg acgcaactta 2701 cttggctgat aagttcgttt catatatgtc tccttaaaga ttatatttct ttattaattt 2761 catagtaaaa aaatttatac aaatatactc gtgtattata ctatacaact ttagtcttgt 2821 caagtacata aaaacggttc aaaaaaacag ctatatatta atatattaca atttataata 2881 tattttattt ataaatttga tattatatca tttaatgata taatgatctg atgaagaaat 2941 acttacttga gaataaatta gaagatatta ctccattaat agaaaattta tctaccgagg 3001 taaagaaata tataccaagt aatgaaatgg atttatttgc agctgcatta tatgaagtaa 3061 ttatgaatgc aattgagcat ggaaatctta atattttata tgaaaccaaa aaaaactggc 3121 ttaagaaaaa tatttaccat aaaaaattaa aagaactctt aaaaaccgaa aaagctaaaa 3181 gcacaaatgt agaaataaca ttgcagatag aagaagataa tattactatt gcagttaaag 3241 atcaaggact tggatttaag cctaaacagg aagcaaaaaa aataaataat gacggatttg 3301 cacgtgaaag cggaagagga attatgatga ttaaatcata ctttgatgaa gtgaaattca 3361 ataaaaaagg caatgttata acattaacaa aattaataaa aaaagaataa ttttttgaaa 3421 tataaacttt tctttaaact aagaaaaagt tatcagataa ttttataaaa atttattaat 3481 agcagcaata aaataatttt taaagagatt caatttatgt ctaatgataa aaaaacaaaa 3541 aaagtgaaaa atactaaata tttccgtaaa tcacctccta tacaattgga tactggattt 3601 gtaagtttag aaagatttat ggctattaat gaatatgatg acggatcttt ttccagagaa 3661 tataactgcg atataataaa tagaaaagga agagatgctg ttattatagt accatataca 3721 tatatagata atcaaataca tgttcttatg ataagcactt tcaggcctgt tgtctattat 3781 agagaaaaag ttatgacagg aaaaagaccg gaagaaattg atgaacatac tatgaatttc 3841 ttagaattcc cggcaggtat gcttgaagaa gatgaaatta atgagaagaa tcctaatcag 3901 ggaataaaaa aatgtgctaa aagagagctt gaagaagaga caggatatag tgtagattta 3961 aaaaagataa atgtactagg gcataaatac tatagttctt cagggattat aacagaaaga 4021 attaacattg ccacatgcga tataacagga ttaactccaa aaaaagagat tcaaactgac 4081 ggatctgtaa tggaagaaac tatagaatct ttttttgtac catttgataa ggctatgaga 4141 tggtgtaaag aaggtgttat aaaaaatgca ggtactgaaa taggacttca taggctttat 4201 ttttcaatat tatacgaaca tcaaaaaaac cataatttaa tacttcaaaa aaggcttcac 4261 actcttttaa atgaaataaa ttctcttaaa aaaagtgctg aacattataa taaattaata 4321 agagaattta aagctactgt atcacatgaa ttaagacatc ctttcacaga aataatggga 4381 tatattaatc tgcttaaaaa gaataatatg cctgaggaaa aaagagaaga gttctttaat 4441 atagtttcaa gaagtattaa aaaactttat gatactaaca acaatctaat acagatcgca 4501 ttaaaagatg atgaaagttc aaaatatgta tctgaattta atataaaaga agaacttgat 4561 ataatcatag atggttataa attcatttat cctaaaaata taaatataga aatgaatata 4621 gaaaaaaact gtactacatt aataggatat catgaaagat tcagacttat tatggaaggc 4681 ataatatcaa atgctttcaa attcactaaa tcaggaacca tatctataaa tgtaagacct 4741 ttagatacga tagaaaaaaa agaacttgat ttctcacctg atctatttaa ttaccatact 4801 atgaaaaata taatacctaa tgaaattgaa ataatagtaa aagatacagg aaagggaata 4861 aaaccaagta aattaaaaaa agtatttata ccattttatc aagctgattc tagatttgaa 4921 agagagtatg gcggaatggg tattggttta tctgttgtaa aagatttgct tgatactatg 4981 caaggcacaa taaatataga cagctcagaa ggtgccggaa ctatagtaaa attaagaatg 5041 ccttttggta ttccaagcaa gaattaataa tattattaaa ttagactaat aattcaaaac 5101 gaattcatat tattaatatg caataattta aacaaatatt aggtaagctg tgaaatttaa 5161 gttttaaaac ttatttttac tccccgcccc ttttattttt caatcaattt ataaatatac 5221 aatttcatat ttcatcatta tctacttaga aaatataaca cccacccaaa atttttttta 5281 attaagcata ttaatcaacg cacgctaagc aaaattataa atattaataa cattggaatt 5341 caaatttaaa tatattaaaa aaatgccgtc caccgtgcgt taattaaatt ataaatttta 5401 tattctctag ggcgggcatg ctttttctta aacaaaatac taaatataat gaaataataa 5461 atactataaa aataaaaaaa caaaagggcg ggaaatgaaa ataaaataac aaaaaatata 5521 gttttaaata ctaaaaatat aaatatataa ccatataata aataattgaa tgcaaacaat 5581 ttttattaga aataataaat taatttctat ttttttttat tattattttt cttccattat 5641 cttcaaaata aaaatcatct gtatataaag aaataagaaa tatccctctt ccgctgtctt 5701 tataaatatt atcctgagac tctgttaaac atatcatagc tgagaaataa tcaaaaccat 5761 ctccctcatc ttctatagcg accttaataa tttcatcatt tatataaaaa tctatactta 5821 catttttatt ataatcattt ttatttccat gaactattgc attagttaaa gcctcctcaa 5881 aagctactct aaatgcatca catccttcta tttgattaga atgtaaaaaa tcaaaaaaat 5941 cattggaaac tttaggtacc aataacttat tactaggaat ttttactgac aatatttttt 6001 ccactttatt tccgcaatat tctatactca tagttcaact ctatagcaat aataaattat 6061 agtactataa ctacttacat tatatttaac tataaagtat agtaaaataa gcttcattgt 6121 caagtttttt aaaatataaa aatattgaca ttaattctat tttgaataca atttaattgt 6181 tattttattt ttttataaag gattttttat gaaatacatg aacctttaca gaggatatga 6241 aaagagaaaa gaagctattg ataaaaaaat atcttctatt atagagagaa gtcagtttat 6301 attcggcgaa gaattagaat cattagaaaa agaattatca aattatactg gtgctaaata 6361 tgctgtagga gtttcatcag ggcatgttgg tttagtactt gctcttttag cattaggatt 6421 caatgctggt gaagatcatt ctcaaaaaga agtaatagta cctgctatga cattcttttc 6481 taccgctgag gctcctgctt tcttaggaat gaaagtaaga gtttgcgata ttgatgaata 6541 ctttaatatg gatgtaaaaa agcttgaaag tttaataaat aaaaatactg ttgccattat 6601 acctgttaat ttattcggac aatgtgctaa ttatgatgtt atattagata ttgctaaaaa 6661 gcataatata tttgttatag aagatgcatg tcaatcattc ggagctagct ataaaaatat 6721 caaatcatgt tctggaaaat taggagatat tgctgtaaca tcatttttcc cagctaaacc 6781 attaggctgt ttcggtgatg gcggaatggt gtttactaat aacgaagaat tatataaaaa 6841 ccttaaacag cttcgtcatc atggtgatga aggcggaatg attcatgtta aattaggaac 6901 tacaggaaga cttgataatt tacaggctgg tattttgctt gagaaattta aaggctttga 6961 tgcagatatg gatcatagaa gaagtgctgc tgaatactat aatgaaaaat taaaagatgt 7021 agtaaaagta cctcaagttg ctgagtatac tcaaagcgta catgctcagt atgttataca 7081 ggtggaaaat aacagagatg aagtaagaac taaattaaat gaattaggaa tacctactgc 7141 actttattat cctcatccta tacacttagc tcctatactt gtaaaaaaat tgggatataa 7201 agaaggagat atgcctgtat ctgaatatgc ttcaaaacat aatcttgctt tgcctataga 7261 taatgatatt cttaaagaag aacaagatat ggttatagat gctgtcaaaa aagttataaa 7321 ataataataa atatataaat gataataaaa aaagcaggtg tttaggcact tgctttttta 7381 ttttatttat atgaattaac ttttagatag gaaattatct ttcacttttt tttgtaattt 7441 catgatttaa agaaattaat ttattatact agtaatataa cttaataaat ttgacaaata 7501 gaacaatgtt ttatatcata tttaatatga ggagaaaata tgaataatct taataaatta 7561 atagaccata ctattttaag acctgatgct acaatagatg agataagaaa gctatgtata 7621 gaagcaaaag aatatggatt ttattctgtg tgtgtaaatt cagcttatgt aaatgtagct 7681 tataattttt tattgcattc agatgtaaaa gtatgttctg tagtaggctt tcctttgggt 7741 gctatgatga aagaggcaaa agcttatgaa acaaaagttg ctgttgatag cggagctgat 7801 gaaatagata tggtagtaaa tgttggtttc ttaaaaagta aaaaaataga tctttttgaa 7861 agagatataa aaaaagtaag agatgcatgc catgctagtg tattaaaagt aattatagaa 7921 acttgtcttt tgacagatga agaaaaagta ttagcatgta aaatagccaa agaatgcgga 7981 gcaaattttg ttaaaacttc tacaggattt tctacaggcg gagcaacaga acatgatgta 8041 aaacttatgc gtgaggctgt aggcaaagaa atgggagtta aagcttcagg cggtataaaa 8101 acttatgaag atgctataaa aatggtagag gcaggcgcta acagacttgg aacaagcagc 8161 ggaatagcaa taatgaaatc tgcattaaat taggagacag ctatttatgg aatataaaga 8221 acctaaagca ttctatgatg aagaggcatt taaaaatgat ctccttcaat accatataaa 8281 attaaaaaaa ggcgatgttg caagatatgt acttcttcct ggcgatccta aaagagtggg 8341 atatattgca aaatttttgg ataatcccga attaaaagct gattacagag aatatgtaac 8401 agtaacaggc aaatacaaag gagtagatgt ttctgtaact tctacaggta taggaggtcc 8461 ttcagcttca atagcgatgg aagagcttat taaagttgga gctgatacat ttataagagt 8521 tggaactgca ggcggactta gccttaaagt aaaacctaat gatttggcaa tagctcaggc 8581 tgcaataaaa gatgaaggca ctacaaaaga atatatacct cttgagtacc ctgcgattgc 8641 caatactgat gttatgcttg cattaagaga tgctgccaaa aaaataaatg ctaattatca 8701 tataggtgtt gttcatagta aagactgttt ctatggagaa ttagaacctc agaattcttt 8761 tttcagagaa aagtttgaaa ataatcttaa atattatact ttatgcggtg ctatagcttc 8821 cgaaatggaa tgtgcagctc tttttgcatg cgcatcttta agaaaagtaa gagccggagg 8881 aataatgcat atagtggaaa atactatggt tgagagaatg ggtactcatt tagaatacag 8941 cgataatata gaaaatatga tattaacagc attagaagct attattttat taaatgagaa 9001 agacaaaaaa gctgaaaaga agtaattaaa gaggtaatca aatatgtttc caaaagctta 9061 ttatcaagaa aatgaaaatc tagttcatca tttaaaatta aaaaaaggtg atgtcggaag 9121 atatgttatt atgcctggag atcctaaaag atgcgtaaaa atagctaaaa gatttgataa 9181 tgcaaaattg atatctgatt atagagaata tgcaacttat acaggatata taaatggtgt 9241 taaggtttct gccacttcac atggtatagg tggcccttct acagctatag ctttggaaga 9301 acttattaaa gttggtgcag atacttttat tcgcgtaggc acttgcggag gtatgaatat 9361 ggaagtattg cctggtgatg ttgttatagt taatggagct ataaaaggcg gcggtacaat 9421 ggacaactat atccctaaag agtttccatg tgttcctaat atagatgtac ttgaagcaat 9481 gattgaaggt gctgataaaa taaaaacaag aactcatgta ggtgtcgtac agtgtaaaga 9541 tgctttctat gctcagcatg ctcctgaaag tatggctgtt gataatgaat tattatataa 9601 atgggatagt tatattaaag caggctgttt agcttctgaa atggaatctg ctacattatt 9661 tgcagttggg gctgctaaaa atgtaagaac aggagctgct atgcttgttt tgcataatca 9721 ggagagagta aaaaataata ttaatgatcc aaaaaactat acaggagaag aagcaataga 9781 tttaataata gaatcaatta aaattttgat agacaaagat aaaaaataat aacaataaaa 9841 aatattttag gatggaatta tgattaaaaa aattatgtta tgtgtgttat ttatcacatc 9901 tttatttgca ttgtcatgca gcaaaagccc aaatactaat acaagtactt ttgaaatagc 9961 tgtacttata gacttaggtc ctattgatga taaatctttt aatcagggat catgggaagg 10021 tgtaaaggat tatgccgaaa attatggtat aagttataaa tattatagag ttcctgataa 10081 ggacatagat tcttatttaa acactataga tcttgcagtt aaatgcggtg ctaaattaat 10141 agtaacccct ggatatatgt ttgaacctgc aatatataaa gctcaagata tttacacaaa 10201 cgtaaatttc atactgatag atggagaacc tcaagacgga acttatacag attataaaac 10261 atcacctaat acagtagcaa ttctttattc tgaagaggaa gcaggatttt tagcaggata 10321 cgctatagta aaagaaggtt atactaattt aggatttatg ggaggtgttg ctcaccctgc 10381 tgtagttaga ttcggatacg gatttgtaca gggtgctgat tatgctgctg ttgaatcaaa 10441 attacctaaa gattctgtta atataaaata tacttatata ggcaattatg atcctacacc 10501 tgaaaatcaa actttagcta cttcttggta taaaagcgga gtacaagtaa tatttgctgc 10561 agctggtgct gccggaaatt cagttatgag tgctgctgaa aataataacg gattggtaat 10621 aggagttgat gttgatcaga gttttgaatc tcctactgtt attacttctg ctatgaaatt 10681 gataagagaa tctgtttata atgctgttgc atcttattat aacggaaatt tcagcggagg 10741 aaaaactact atattaggag ctcaagttaa aggtatagga cttcctatgt ctacttctaa 10801 atttaaagtt tttacagaat ctgactataa tattatatat gactctcttg taacaaaaac 10861 aattaaagta ttaaaagata ctgatataga aaatgtaaat aatttacatt taaattcagc 10921 aaaggttaat tatataaaat gatttgttct ctatataaaa gattagcagt aagaggtgat 10981 ttttaaatat gaaaaaactt cttactcttc ttattgtgtt tgttttttta tacactgttt 11041 cctgcagtaa tacaaacagt ggaaaatcac ttggttatga aatagcagtt atcatgagaa 11101 atatagatga caaatcattt aatcaaagta cttggagagg agtaaaggat tatgctgaac 11161 attatggcat aagctataaa tattataaag ttcctgataa aaatgtacaa tcaacattaa 11221 atgctataga tattgctgtt cgtatgggag caaaattgat agtaacacca ggaagtatat 11281 ttgaacctgc tatttataaa gcacaggata tatatactaa tgtacatttt atattgatag 11341 acggaaagcc tcaggatgga acttacacag attataagac agcaaaaaat actattgcta 11401 ttctttatgc tgaagaggaa gcaggatttt tagcaggata cgctatagta aaagaaggtt 11461 atactaattt aggagttata ggaggtatgg ctcttcctcc tgttataaaa ttcggatacg 11521 gatttgtaca aggggcagaa tttgcagcag atgaattaaa aattcctaaa gatagtataa 11581 atataaaata cacttatgtt ggaaattatg atgattctca ggaaaatcaa aatttagctg 11641 catcttggta taaaagcggt acacaggtaa tattcgctcc ggcaggaggc gcttcttatt 11701 ctgttataaa tgctgctgag aataatggag gtttagttgt aggaattgat gttgatcaaa 11761 gttttgaatc tcctactgtt attacttctt ctatgaaatt gataagagaa tctgtttata 11821 atgctgttgc tgcttattat aatggtaatt tcaatggagg aaaaactttc atattagata 11881 caagagttaa tggagtagga cttccaatgt ctacttctaa atttaaagtt tttaaagaat 11941 atgattataa tatcatatat aactctctta tgagaaaaaa aattagggta ttaaaagata 12001 ctgatgcgga aagtgttgat aaattacctt tgaatttagt aaaaattaat tatataaatt 12061 aattaggaga ttagtatgaa aaaaaatttc ggcttaatga taattattac agcttttata 12121 ttaatgattt catgctccaa aactgaacaa gttggagaat tcgatatagc tttgataaca 12181 gaaggtaaaa tagatgataa atcatataat cagggagctt gggaaggatt aattagatat 12241 gctgaaagta caggaaaaaa atacaaatat tatcaggctg ctgaaaataa tacagaagca 12301 tatattgatg ctatagattc agcagtttct gaaggcgtaa aattaataat aactccgaat 12361 tatttatttg aaacagctgt atacaaatct caggataaac atccggatgt taattttata 12421 attatagatg gtgttcctca agatggtact tatactgatt tcagaataga aaaaaatgtt 12481 catgctatga tttatgctga agaagaggct ggttttttag cgggatatgc tatagtaaaa 12541 gaaggatata ctaacttagg agttataggc ggaatgcctg tacctcctgt tataagattt 12601 ggatacggat ttgttcaggg tgcaaattat gcagctaaag aattaaatat gcctactaga 12661 agcataaaaa taaattatac atatattggc aatttcagtg ataccggtga aaataaagaa 12721 cttgcttctt cttggtatca aaatggggtg caggtaatat ttgctcctgc aggaggtgct 12781 ggaaaatctg ttataagttc tgccgaagaa aataatggat tagttatagg tgttgatgtt 12841 gatcaaagtt ttgaatcccc tgttattatt acttctgcta taaaaagaat aagaaattca 12901 gtttataatg cagttgattc tttttataat ggtactttta aaggcggaca aactactata 12961 ttagatgcaa aagtaaatgg tatagggctt cctataaaaa cttcccaatt taaaaacttc 13021 actgagaatg attataatgc catatataat cagctttcag aaggtaatat taacatttta 13081 aaagaaagaa atgcgagaac tgtagaagaa ttacctttgg atatagtaga aattaattat 13141 ataaaataaa ttttggcttt aataattttt agcaaataaa tatattataa aataggagac 13201 atcatattat gaaaaaaatt cttgttttaa tcatcacctt aatgagcttc attttaatga 13261 tttcatgcgg cggcggaaaa aaatctggag gatatgaact agcattaata acagatgttg 13321 gtactataga tgacagatca ttcaatcagg gatcatggga aggattaaca aaatatgctc 13381 aggaaaaagg catatctcat aaatactacc agccttctca aaaaactact gatgcttatg 13441 ttgatgctat agatttagca gtatctgcag gtgctaaatt ggtagtaact cctggtttct 13501 tatttgaacc tgctgtatac agagctcaag acacacatcc gaatgtaagt tttgtacttt 13561 tagatggtac tcctcaagac ggaacttata ctgactttag aattgaaaaa aatgtttatt 13621 ctgtacttta tgctgaagaa caagctggat ttttagcagg atatgctata gtaaaagaag 13681 gatacactaa tttaggcgtt atggctggta tggctgttcc tgctgttata agattcggat 13741 acggatttat tcagggtgct aattatgcag ctaaagaaat gaatatgcct gtaggaagca 13801 taaaaattaa ctatacttat ataggtaact tcaatgctac ccctgaaaat cagactttag 13861 ctacttcttg gtatcaaagc ggtgtacaag ttatatttgc tcctgcaggc ggtgccggaa 13921 actctgttat gagtgctgct gaacaaaata acggattggt tataggtgtt gatatagatc 13981 aaagtgctga atctcctact gttattactt ctgctatgaa aatgcttgga gaatctgtat 14041 acaatgccat agatgatttc tataaaaatc aattcccagg aggaaaatct gttatacttg 14101 atgctaaagt taatggtata ggactcccta tgtctacttc caaattccaa aaattcactc 14161 agaatgatta tgatgctata tatcaaaaac ttaataatag tgaagtaaaa gttcttactg 14221 ataaagatgc taaagatgtt aatcaattac ctttagatat agttacagtt aatttaatac 14281 aataaagaat attaatacta aaatatttta agagagatgc cggatataat ctggtatctc 14341 tatttttttt ttataaatat ttgacaattc aaaatcattt aactatattt tatatataat 14401 tattttatta aaataattat atataaaagt tatataggaa atataatgga aaattcagaa 14461 tatgtagttg aaatgcttaa tataactaaa cgttttaaag gtataatagc aaatgataat 14521 atcactatac aattaaaacg aggtgaaatc catgctttgc ttggagaaaa tggagcagga 14581 aaatctactt taatgagcgt gcttttcgga ctttataaac aagaagaagg tataattaaa 14641 gttaatggta aagaagtaaa tattgataat cctaatactg ctaatgcctt aggtattggt 14701 atggtgcatc agcattttaa attagttcat aattttaccg ctttagaaaa tattatgctt 14761 ggtgtagaaa ctgttaaaaa tggaatactt caagttgatg atgcaagaaa aaaagttatg 14821 gaattaagca aaacctacgg acttgaaatt tatcctgatt ctttaataag tgatttaaca 14881 gtaggtatgc agcagagagt agaaatttta aaaatgcttt ataaagataa taacatactt 14941 atttttgatg agcctactgc tgtacttact cctagcgaaa tagaagagct tatgaaaatt 15001 atgaaatctt taactaaaga aggaaaatct attcttttca taactcataa attaaatgaa 15061 attaaagaag ttgctgacag atgttctgta cttcgtaaag gtaaatatat aggtactatt 15121 gatgtaaaaa gtactacaaa agaagagatg tctgaaatga tggttggaag aaaagtatct 15181 ttagttgtag ataagacaga ggctaaacct aaagatataa tattatcagt aaaagatcta 15241 aatgttaaat ctcctcatag tgaaaaaaat attgttaaaa atgtttcttt cgatgttcgt 15301 gccggagaga tagtatgtat tgctggtatt gacggaaacg gacaaagcga acttatatat 15361 gcactcacag gtttgattga tatgtcaagc ggaagcattc atttaaatgg caaagacatt 15421 actaacctat ctataagaaa taaaactcta agcggaatag gacatattcc agaagacaga 15481 cataaacatg gacttgtact tgattatact cttggagaaa atacaatact tcaaacttat 15541 ttcacagaaa gatttcaaaa taaaggcttc ttaaaattca aagaaataga aaattatgct 15601 aatgaactta taaaaagatt tgatataaga agtgcggagg gtgctaaaac tatagctaga 15661 agtatgtcag gaggtaatca gcaaaaggct attattgcta gggaaataga cagaaatccg 15721 gatttactta tagcggttca gcctacaaga ggattagatg ttggggctat agaatatata 15781 cataaagaat taataagaca gcgtgataat ggaaaggcgg ttttacttgt ttctttagag 15841 cttgatgagg ttatgaattt aagcgacaga atacttgtta tatatgaagg cgagattgta 15901 gctaatgtta acaataaaga tttaactatt aatgaattag gtctttacat ggcaggctct 15961 aaaagaagtg cataagattt tggtttatag cattataatt gtttttatta tattctttgg 16021 ttaatagttg ttatgagaaa tataaataga atgaatgatt actttgtgcg ttaccttcta 16081 ggctctattg gtaatgaaga tatacttgaa aatatagtca attgtgtgct tatagattca 16141 ggttttgaag aagttcataa tttagaaata attaatcctc ataatttacc tgaaaatatt 16201 aatctaaaag aatcagtact tgatgttaag gctattacta aagataataa aaaaattatt 16261 atagaaatac aattatcagg gaatatagat tttgttaaaa gaatatatta ttatatatca 16321 aaaaatatag taagcgaatt aaatgaaaat gaatcttatg atattattag ccaggttata 16381 agcattaatt ttgtaaattt caatatggac tttaatgatg aaggtaagga acatagatgc 16441 tttaaattaa tagacactca aaatcataat gtatcattag atattattca aatgcatata 16501 atagaaattc caagatttac aaaaatatta aataattcta gtatagatga tattaaaaaa 16561 aataaaatat tatcttggat tgaatttttt acagttaaag atttagataa agttaaagaa 16621 aaattaaagg agcttaataa tattatgcca aaagtaatag ataaatatga gagatttata 16681 tcaagtgaag aagagatgga agtttataat gccagagatg catttttata cggacaaacc 16741 ataatgctta aaagagaaag agaagaaggt ataaaagaag gcatagaaaa agaaaaatat 16801 tcattagtaa gaaatatgaa aaagaaaaat atggatataa atcttattag tgaattaaca 16861 ggtttgagta tagaagaaat agaaaaacta taataaaaaa ttatgagtct attttaagtt 16921 tacttaaaat aggctaaaag cgaataattt ttttataaag gatataataa ataaaaataa 16981 aaaatactag ataaaattat taataatgta ttgttataaa aggagtgctt aatggattta 17041 aaaaacaaat tggctggtat tttggagaaa gaaggatttg ttaatatatt ttcttctttt 17101 ctcgctatta ttatagggct gcttctgggt cttataatac ttcttataag taatgttcat 17161 gatgcttttc ccgcttttat gacaatactt tcaggaggat tttctggagg ctctagagga 17221 atgggacagg ttatatacac tgccacacct ttaatactca cagggctttc ggttggattc 17281 gcttttaaaa acggactctt taatatagga gctcccggac aatttatagt aggtgcttat 17341 gctgctgtat tagtagcagt aaaatgcaca ttccttccgc ctgctctaca ttggtttgta 17401 gctttaatag tttcttttat agccggagga ctttgggctt atttacctgg ttttttaaag 17461 gctcatttca atgttaatga agttatttca agcattatga tgaattatat tggtatgtat 17521 ttagttaatt atcttgttac gcttacagtt tatgatatgc ttaaaaacca atctcaaaat 17581 attcctcctt cttctatgat tcctactatg ggacttaatg ttatattcag aggttcaagt 17641 gctaacggag gattcttcat tgctgtaata gtagtaataa tagtatatat aatactttca 17701 aaaactacat tcggtttcga gcttaaagca tgcggactca ataaagatgc aagtaaatat 17761 gcaggtatta acgaaaaaag aaatattatt ctttctatgg ttatagcagg agctttagca 17821 ggacttggcg gaggactttt atatctttct ggagtgggaa agcatataga agttgttgat 17881 atacttgctg aagaaggttt tatgggtatc cctattgcat tactcggact atctcaccct 17941 ataggaatat taatcgccgg actttttatt gctcatataa cagtaggcgg tttttatatg 18001 cagatatatg attttactcc tgaaattata gagatgatta tatcttctat aatatatttc 18061 agtgcttttg ctttactttt taaatctatt gttggattta tatccaaaaa gctagtcaaa 18121 aaagaagaaa aaaatgctaa tgagtaaaga atagaaaata taaaaggaga tttttttaat 18181 ggaaacaatt tattttttag tacagcagac tatgtttttt tctattccgc ttttacttgt 18241 agcattaggc ggaatgtttt ctgaaagaag cggagtagtt aatattgctc ttgaaggtat 18301 aatgataatt ggggcttttg caggaatatt ttttataagc agattaggag ctaatttccc 18361 tcctatgata acattatttt tagcgatgat tatatcagct ttatcaggtc ttatattttc 18421 tcttcttcat gcttatgctg ctattagtat gagtgctgat caggttataa gcggtacagc 18481 tttaaatata tttgctcctg cttttgctat atatgttaca agagctattc aaacagttca 18541 gcaaataagt ttcgttaata attttagaat agaatcagta cctatacttg gaagcattcc 18601 tataatagga ggattattct tcaaaaacac atacataaca acatatatag gattcataat 18661 attagctcta tcttggttca ctctttataa aactagattc ggacttagac taagaagctg 18721 cggagagcat cctcaagctg cagattctgt aggtattaat gtttataaga tgcgttatat 18781 tggtgttgct atatcaggag cattgggagg tttaggagga ctagtatttg ttattcctac 18841 ttctacaaac tttaatgcta ctgttgcagg ttacggattc ttggccttag cagtacttat 18901 attcggacaa tggaagccta tgaaaatact ttatgctgct ttcttcttcg gacttatgaa 18961 aacattagct tctgcttatt ctggaatacc tatacttgca aatcttccta tatctaacaa 19021 tatatacaaa atgattcctt atataacaac tataatagta cttgcattta cttctaaaaa 19081 ttcacaggct cctaaggcat caggcattcc ttatgataag agtgtaagat aa //