LOCUS NC_012225:13 19271 bp DNA linear BCT 26-AUG-2011 DEFINITION Brachyspira hyodysenteriae WA1, complete genome. ACCESSION NC_012225 SOURCE Brachyspira hyodysenteriae WA1, complete genome. COMMENT locus start: 1071159; locus end: 1090429 FEATURES Location/Qualifiers source 1..19271 /organism="Brachyspira hyodysenteriae WA1, complete genome." gene 0..794 /gene="flgG" /locus_tag="flgG" /db_xref="1071159..1071953" CDS 0..794 /gene="flgG" /locus_tag="flgG" /product="flagellar basal body rod protein FlgG" /translation="MVRSLWTAASGMNGMQFKTDTIANNLANVNTIGYKKVRADFEDL IYQNLKIQGTPATEDTVTPVGLQTGLGVKSAATQKMFDQGSLQATGNKLDLALEGEGF FQVLMPDGSVSYTRDGSFKIDANGQLVTSNGYRLVPEIVFPENFLVEQISISREGIVS VKIGDENDPVEIGQITLHRFINQPGLLSIGDNLYKETIASGPAFEGEPGANGFPRIHQ GFVEMSNVKVVDEMVDMIVAQRAYEMNSKAVQTSDNLLATVVNLKR" gene complement(876..1229) /gene="" /locus_tag="" /db_xref="1072035..1072388" CDS complement(876..1229) /gene="" /locus_tag="" /product="LT GEWL, Lytic Transglycosylase (LT)" /translation="MVALIKVESSFIPTALSRKNAYGYCQITPIANKDVDPKLNRYDP RDNIVLGVRFIDKILDKFDGDIVKSLRYYNAGNAYDIYGESYAEKIKYEYDTMVSLYV KENSSYGAIYRKEIF" gene complement(1590..2429) /gene="dapF" /locus_tag="dapF" /db_xref="1072749..1073588" CDS complement(1590..2429) /gene="dapF" /locus_tag="dapF" /product="Diaminopimelate epimerase" /translation="MDLSFTKMHGTGNDYIYINCFKEKFTVEDAIKYSPILSHRHYSI GADGIILIMPSDKADVQMRMFNYDGSESEMCGNGIRCVAKYAYDRGISKNNPMKIETL RGILEAELFLKDEEVDTVEISMSSPILEGLKIPTTIDKTPIINEPIIFNDKTYYFTAV SMGNPHAVIFVNDLHNMDISSIGSYMENNSIFPNRTNVEFVEIINRGEVKQRTWERGS GETLACGTGASAVCVAGFISGRTDNIILNHLLGGDLILRYENDNVFMKGEARYCFEGT ITL" gene complement(2612..4063) /gene="katA" /locus_tag="katA" /db_xref="1073771..1075222" CDS complement(2612..4063) /gene="katA" /locus_tag="katA" /product="catalase" /translation="MSDKKLTTEFGAPVENNQHSMTAGARGPMLLQDVWFMEKMAHFD REVIPERRMHAKGSGAYGTFTVTHDITQYTKAKIFSEVGKKTDLFVRFSTVAGERGAA DAERDIRGFAIKFYTEEGNWDLVGNNTPVFYFRDPLKFPDLNHAVKRDPKTNMRSAQN KWDFLTSLPEAIHQITIDMSDRGIPYSYRHMHGFSSHAYSFINKEGKRYWVKFHFKTQ QGIKNLTDQEAEAIIAKDRESSQKDLFEAIERGDFPRWNMKIQIMTEEQANASKRNPF DLTKTWSQKEYPLIDVGVLELNRNPENYFAEVEQSAFSPSTIVPGIGFSPDRMLQGRL FSYTDTQRYRLGVNYSSIPVNAPKFKPNTYHRDGYMRVESNGSKVEYEPNSQGEWKEQ KEYAEPPLKIYGDAYRYDHREDDDDYYTDARALFNLMTDAQKQVLFENTARDMNGVTK EVQLRHIKNCMNVDKAYGLGVAKALGFDEKDIK" gene 4309..5268 /gene="hemH" /locus_tag="hemH" /db_xref="1075468..1076427" CDS 4309..5268 /gene="hemH" /locus_tag="hemH" /product="ferrochelatase" /translation="MGGPRNFDEINTFLVNMFNDYYILNIKNSFIRGMIAKKIVNKIK PDVIKHYEAIGGKSPINEYTEKLINKLNELDKSKDYKYIMNYTPPYSYDVLKELKENN IDNITLFSMYPQYSEVTVKSSLENVYKAMKKLKYNPKINIIDRYYDNEYYNNSVVNLI KNSIADKNAEEYILIFSAHSIPKMYADKGDPYEYECNYNVQVLREKLNNAGLNFKDIV LSYQSKIGKIEWLEPSTIDTIKKYSGEKLIIYPLAFTIDNSETIYEIDIEYREEAINK YNIKDFILCPCLNDNTDFAESIIEISNSYNKQNLNIHYNKKIV" gene 5508..11234 /gene="" /locus_tag="" /db_xref="1076667..1082393" CDS 5508..11234 /gene="" /locus_tag="" /product="putative alpha-2-macroglobulin domain protein" /translation="MITGVSMFAAVAIDRTTPIGENTSRANYEAITVTFNQQMVALQA IKEVTNQYFNFNVDVKGTYKWLSINTLAFYPSEPLPDNTAIEVTLKKGIKSELTGDIL ENDYTWTFNTLRPIMQKSSPYDRQSELPTDVNIVVYYNMPIYLQSAKEKIQLIASNNN TAIDFDVRYAKIEDLREWETNSYELEQVLVIKPKKALAKNDEITVYIEEGLAAVNGNL GTANSSSFNFSIHDEFYFKGNSEQTVTASYSPEAPKLEFSTRVEWADLIRNMEITPEI QLPTEEEIQQNSWSSKSFSLYQLRFNPNVTYNIKINGSLKDSYGQTLAQEQNITLNVT DYNPSVSIPSGMGVVESYEGIKLPVQVMNPNTINIQSRYIDKENIIPFLFVNKQVYRY DETPEFRRYTNQYKNLFGYNNTSEYTPDVERNRYITTALYLTNYMDNKQYGLLSIKFD SKTGYQSQYDYSTSSQIQITSMGLTGKFSGDSNTIFVTDLKTGMPVEGAEVEIRDDFN RVLARATTDENGIATTKGFRELGIKRASRWDTPRQWAIVTKGDDVSFINSDWGTGVSP WRMDISYDYSPADRDYNGSMFTERGLYKPGEEVHIKGVIRENILGNWKIARDFKTGLY TVNNSRGEEIHKGTVTLNEYGSYLIDFTLPADAPTGYYSVNVEFKSDSNKQSDEEKQE GVKDQTYSLSQSFRVEEFKPLEYESRLWVEDKNYYLGDTMPIKMSGWYLFGEPMISNQ VDYNISMNETFFTPPNNAGFRFTKLSWFEDEYYNNYYSMIANGTGALDENGEYAYAPT IDASRSIHAAYVTIESTVSGEDSQRVSTTKSVLVHGSDYYIGIKRQGYFLETDKPTQL EFIAVDPEGNRLEGKKIEIQVIRRHWESVRKAITGGRFEWESKQIDDVVETTTVTTKK DPVAYSFTPTNSGLYIILARAKDSKNREVASDEYMYVIGKDYAPWAMFDDDLLELITE KEEYQPGETAKIMIKSPYESATALVTVEREYVIDSYVTNIEGSTALIEVPIKPEYLPN IYVGVSLVKGRVENEAYTNYATDEGKPSFKIGYAGLSVSPREKELNVKITKSADTLEP RDEMTVDLYVETKESQPMETEIMLSVVDVGVLNLIGYKTPNWFNTFYGQRPLSVASAD TRIHLIGQRNYGEKGDTPGGDGMRAANDMMAKAEAMGMDVFSIRKNFLTTAFYQGRVK TDANGKATVTFNLPDNITSFRIMASAINKDGYFGASDDVVVVKKNIMLMPTLPEFAYV EDKFKAGSIVYNYSDQDLEIEVQAVASNATIENASQIITVPKGGNADVRFDIIATNRG EAKVTILAKGGEYTDAVEKAFEVNIPMTTESVALFSSTTNNNTDLMLRIPNITEAYKG AGDLEVYMSPSAFSELTGGINYLINYPYLCLEQQLSRVYPIITSKRLLVDMKLTDISE ENLDKTVQDFLKMMPTYQSPDGGFSYWPSKTWVSPWLTAYAADAMIKAKKEGYTVDEN SLKLALEYINNYAKSGNAEKPSFWQDEYINLSSIAYIAAVLSEGGYNANDVKAIIDRI YPQVNNIPFYGQVQLMRAMYYNKYDNKALTEVRQYILNTIKEDPNTAHYELEAYYSNL YWIHSSSVRDTSVALYALIETGYDNAINEKVVRWLVQSRKNGRYLNTQDNVSVFAAMN MYYKKYENVKPNFKAEFIYQGKTLLEETFTARTQPSLTKKYTLDEFMNERLSNSNTRS ALANIKRNGDGRLYYGVRLTYAPRELAVNRDMGIKVERRYETKDGRVLDLTKDKFKQG EEYVVVVKVTAPYERHFVVVDTPIAAGMRILNASFATESSEVKNLTGNAGKPTWWWGG FNHTENYNDKILLFADMLSDGEHEYRYVVRAVTPGEYLLPATKAEEMYNPEVFGYDGQ HKVVIETK" gene 11738..12421 /gene="" /locus_tag="" /db_xref="1082897..1083580" CDS 11738..12421 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MTSENKHIIISGELALILVVVMNSFGVVLMLYSGSGISAISSVP YAFSEVIKNISLGTFTYIFQTLLVLALMILRKKFVGEYLFSFVVGFCFGKFVDIHAAW INHLPLTITSRIIYFIISYFILAFGIALSNRCGLPIIPTDLFPRELSDIIKIPYAKVK ITFDVICLLTTAILTFVFLGHIKGLGIGTVLAAFTMGKSISFIGKLLDKKIEFIPYIK KLLHKENNA" gene complement(12424..13329) /gene="murB" /locus_tag="murB" /db_xref="1083583..1084488" CDS complement(12424..13329) /gene="murB" /locus_tag="murB" /product="UDP-N-acetylmuramate dehydrogenase" /translation="MVKSFNGVLSKENVSLKKFNTFRVSAKALEFYMPETINGFIDLI KYLNDNNKRYMILGGGSNVLFLDKVIEFPIIHMGFFSRIEHTSHNILAYSGAKVSDVV KYAYKNAFTGLEFLSGLPGTIGGAAYMNARCYEHSVSEFIDKVGIIDDNFEYMHINVE DCEYAYKRSIFQDKKYVIVDVRFKLNKGSKKLIKPEMKKFYKDRKNKNQFKYPSAGST FLNDYETNMIAGKVIDSINMRGTRLGGAMVSPYHANFIVNYNNATGRDILNLMRKVRE EVYNQKGITLNAEVRIISNDENEKF" gene complement(13391..13900) /gene="" /locus_tag="" /db_xref="1084550..1085059" CDS complement(13391..13900) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MSKYKPTNKIELRSLIENNNIYLGDIDTSLITDMSMLFDKPNFA CFEGSYSEYESYNVRIDFSGIEKWDTSNVINMRSMFHNIKNFNIDINNWNVSNVTDMA YMFFGAENFNHPLNKWNVSNVKSMTCMFKNAYNFNQDLNDWKINKDADIKDMFVNTSL IEKPHWYNL" gene complement(13906..14883) /gene="scpA" /locus_tag="scpA" /db_xref="1085065..1086042" CDS complement(13906..14883) /gene="scpA" /locus_tag="scpA" /product="puttative segregation and condensation protein A" /translation="MEENINETQQENNNAINADTSAKEETENSKPDYKEFTVSLSSID YEGPLSILFDMLKRSEKSIYEVSILEIIDQFVEYLKAQAALNLDSTGDFLVVASEFHL YKSKMLLPHDMDDDKFTDKLKFEIVEQMLEFQRYKMVSEELDKLQDTSDTIFERKDTE RVKFFKTVNTDDNEVAWKDITLYDLVYAFTKVQFVPETDLAVLSGMSNFHIDNAIDMI RIKLSETAFFPFITLFKDGVTKRQLVTFFLAMLELVKEKEILLKQEMKFKEIYVFKRD EKFMPKVEETDQEEQENHDAKEVSNNEAPIAESNENTENNSSEENNQSN" gene 15021..16001 /gene="" /locus_tag="" /db_xref="1086180..1087160" CDS 15021..16001 /gene="" /locus_tag="" /product="oxidoreductase domain containing protein" /translation="MKKINIGFIGAGKIAEKMAQTISKIKEAQSYAVSARDIKRSKAF AKKYGFKKFYGSYEEMLKDENVDLVYIATPHSHHYEHIKLCLENNKNVICEKAFTVNT KQAREVLILAKKKKLLLAEAIWTRYMPSRQIINDTIKSGIIGKVTSLTANLGYVINKV PRLIEPELAGGALLDVGVYTINFALMVFGNKIKKIDSSCVKTSKGVDEQNSITLTFED NKMAILNSTMSALTNREGVINGDKGYMVVKNINNPESITVYSLDRKVVKTIKVPKQIS GYEYQIISCINAINNGKLECEEMPHEDILRVMNIMDTLRRSWKIKYPFEK" gene complement(16078..16584) /gene="" /locus_tag="" /db_xref="1087237..1087743" CDS complement(16078..16584) /gene="" /locus_tag="" /product="acetyltransferase" /translation="MDITIKKAGLEDVFDISKLHAICWKDAYKNIIPDSYLKRIYLDD WCEEFEEGINNKTREAHLAYIDGKPIAVISHGKSRCNMEGYGEIISLYVHPIYQGSGI GKLLLEQAVKYMKESGYTNICLCVFEKNEDAKKFYEKNGFKDSGTKNTLKIDDEDIEE SIYVYDIN" gene complement(16687..17265) /gene="ruvA" /locus_tag="ruvA" /db_xref="1087846..1088424" CDS complement(16687..17265) /gene="ruvA" /locus_tag="ruvA" /product="Holliday junction DNA helicase RuvA" /translation="MFAFIEGKVQIISEGVIALLCNGVGYEIIVSKKLDVKNDDNIRL YTKLIHREDAMILYGFLTREEKNMFTTLMSASGVGPKLAMEVLSTYSINDLMHILFNK DINLLKKVSGMGVKKAEKLLFELRDKIEKIDINISPSVISNDNESDVIKALISLGFSN NEAVKALSAIENKDNMTTEDLISNALRNLSTL" gene complement(17265..17474) /gene="copZ" /locus_tag="copZ" /db_xref="1088424..1088633" CDS complement(17265..17474) /gene="copZ" /locus_tag="copZ" /product="CopZ, Copper chaperone" /translation="MKNITIKIKGMGCQNCVKAVTEELSALDGISKVNVSLENACAEV EYDESKVTTDKMLETIKELEYEPSL" gene complement(17531..19270) /gene="" /locus_tag="" /db_xref="1088690..1090429" CDS complement(17531..19270) /gene="" /locus_tag="" /product="Signal transduction histidine kinase" /translation="LILSSALMFIGILFTVQYNNIMYSQVMIVNIMEMLEKEIDLYDV QTEDAFRKFVLQSDKEELRISIISTNGVVVADTMTDTSKNPMGNHTNRSDVIEALHSM ENKPAFSINTSISQKTPYMYVSKKIKADDKRDYILRVSIPIESVNKYLISFLFTAVMV IGIVIIIMALVLPLMSRNIMIPFYMIKETLDNIYNNKSPTPKNLTGYNDINTILYDIN ELAVSLNENITGYQTEREKLNYVLENIAQGIIAVNKNKEIFFINQYALDLLEISDSNI RKLNEIIKDDDVIEKIDNAIEFSRFSKFDVKEHTMDIEISIIPIRNNENISALIKFED VTDIRKVEIEKQDFFINASHELKTPLTSIIGYSELLIATGGGKNQADFIKRINNEALR MKDLVIDMLTLSRIEANWKETVDEEIDIKDIVLDVFESNRIKSEQRNIDVELDIESAV IMANKEKITEVVNNLVDNAIKYTDDDGKVKIYLKNNSDKAIFSVKDTGCGIAPQYLNR VFERFFRVKNNKYLKVHGTGLGLTIVKNICNYYNADIHIKSEENVGTEMTVVFNLYKE EESKNIEKIEKNN" ORIGIN 1 atggtacgtt ctttatggac agctgcaagc ggtatgaatg gtatgcagtt caaaactgat 61 actatagcca ataaccttgc aaatgttaat actataggat ataaaaaagt tagagctgat 121 tttgaagatt taatatatca aaacttaaaa atacaaggaa ctcctgctac agaagacact 181 gtaacacctg taggacttca aacaggactc ggtgtaaaaa gtgctgctac tcaaaaaatg 241 tttgatcaag gttctttaca ggcaacagga aataaacttg atttagcatt agagggagaa 301 ggattcttcc aagtattaat gcctgacgga agtgtttctt atactagaga cggttctttc 361 aaaattgatg ctaacggtca attagttact tctaatggat acagattagt tcctgaaata 421 gtatttcctg aaaatttctt ggtagagcag ataagcatat caagagaggg tattgtttct 481 gtgaaaatag gtgatgaaaa tgatcctgta gaaataggac aaattacact tcatagattc 541 ataaatcagc ctggactttt atctataggt gataacttat ataaagaaac tatagcaagc 601 ggaccggctt ttgaaggcga accaggtgct aatggattcc caagaattca ccaaggtttc 661 gttgagatgt caaatgttaa agttgttgat gaaatggttg atatgatagt ggctcaaaga 721 gcttatgaaa tgaactcaaa agcagttcaa actagcgata acttacttgc tactgttgta 781 aacttgaaaa gataattaaa aaaataatat aactagtaaa tataaaagga ggctttaaag 841 gcctcctttt atattgttta taaaataaat aatattttaa aatatttctt ttctatatat 901 agcaccatat gaactatttt ctttcacata aagacttacc atagtatcat attcatattt 961 tattttctct gcataagatt cgccgtatat atcataagca ttgcctgcat tataatatct 1021 aagagacttc acaatatcac cgtcgaattt atccaaaatt ttatctatga atcttacacc 1081 aagcacaata ttatctctag gatcatacct atttaattta ggatcaacat ccttatttgc 1141 aataggtgtt atttggcagt atccgtaagc attttttctt gaaagtgctg taggtatgaa 1201 gctgctttca actttaatta gagccaccat taatagcgga tcaacatcat aattactgca 1261 aacatcgaaa acatctttta tgaaccaaaa atcctgacta taatgattag atacatcctt 1321 aattaatgtt acccaatcat tagatggaaa ggagtaatca ttgatgttca aactatgcgt 1381 ctcaagattg agattgcaaa gaaataaaac taatattata actattcttt tcataaactt 1441 cctgttaaat tttaatatcc tatagttgta gtataaatta cctataaata aaatcaatat 1501 aaaattatat ttaaaaatta acattttttt ttaaaatgtc agttaaaaaa tatatttttt 1561 ttacaataaa gatatagtgt ataaaaacat ctataatgta atagttcctt caaaacaata 1621 tcttgcttca cccttcataa aaacattatc attttcatat cttaaaatca aatcaccgcc 1681 taaaagatga ttaagtataa tattatcagt tcttccgctt ataaaaccag caacacatac 1741 agccgaagca cctgtaccgc aggctagagt ttctccgctt cctctctccc aagttctttg 1801 cttcacctct cccctattta ttatctctac aaattctaca ttagttctat ttggaaatat 1861 gctattattt tccatataac ttcctataga actaatatcc atattatgaa gatcatttac 1921 aaatattaca gcatgcggat tacccataga tactgctgta aaataataag ttttatcatt 1981 aaatattata ggctcattaa taataggagt tttatctatg gtagtaggta ttttaagccc 2041 ttctaatatc ggagaactca tactaatttc tacagtatca acctcttcat cttttaaaaa 2101 taattctgcc tccaatatac ctcttaaagt ttctattttc ataggattat ttttactaat 2161 ccccctatca taagcatatt tagcaacgca tcttatacca ttaccgcaca tttcagattc 2221 gcttccgtca taattaaaca ttctcatctg tacatcagct ttatcactcg gcattataag 2281 tattatacca tctgcaccta tagagtaatg cctatgactt aatataggag aatatttaat 2341 agcatcttca actgtaaatt tttctttgaa acaatttatg tatatataat cgtttcctgt 2401 gccatgcatt ttagtaaatg ataaatccat aataaaccct taaatatttt ttatattcta 2461 tagtttatat attttataat ataatagaaa ttaagtaaat attttataaa aatacagcta 2521 atacctttta actttataaa aggtattagc cttagagatt aaaatttgat aatttattta 2581 atatttattt atatatatcc aagttttatt aattatttta tgtctttctc atcaaagccc 2641 aatgctttag caaccccaag tccataagct ttatcaacat tcatacaatt ttttatatgt 2701 cttaattgta cttctttagt aacaccattc atatctcttg ctgtattttc aaataatact 2761 tgtttttgtg catctgtcat aagattgaat aaagctcttg catctgtgta ataatcatca 2821 tcatcttctc tatgatcata tctgtaagca tcgccgtaaa tttttagagg cggttcagca 2881 tattctttct gctctttcca ttctccctga gagtttggtt catattctac tttagaacca 2941 ttagactcta ctctcatata tccgtctcta tgataagtat taggtttaaa ttttggagca 3001 tttacaggta tgcttgaata gttaacacct aatctatatc tttgtgtatc agtatatgag 3061 aataatcttc cctgaagcat tctgtctggt gagaatccta taccaggaac tattgtagaa 3121 ggactgaatg ctgattgttc tacttctgca aaatagtttt cagggtttct atttaattct 3181 aatacaccta catcaattaa tggatattct ttttgagacc atgtttttgt taagtcaaaa 3241 ggatttctct tgcttgcatt agcctgttct tcagtcatta tttgaatctt catattccat 3301 ctagggaaat ctcctctctc tatagcttca aataaatctt tttgagaact ttctctgtct 3361 tttgctatga ttgcttcagc ttcctggtct gttaaatttt taattccttg ctgagttttg 3421 aaatggaatt ttacccaata tctttttcct tctttattta taaaactata agcatgactg 3481 ctgaaaccat gcatatgtct gtaactgtaa ggtattcctc tgtcgctcat atctatagtt 3541 atttggtgaa tagcttctgg taaagaagta agaaagtccc atttattttg agcacttctc 3601 atattagttt taggatctct ctttacagca tggttcaaat ctgggaattt taaagggtct 3661 ctgaaataaa atacaggagt gttatttcca actaaatccc agtttccttc ttcagtatag 3721 aatttaatag caaaacctct tatatctctt tcagcatctg ccgcacctct ctcacctgcc 3781 actgtagaaa atcttacaaa taaatcagtt ttctttccaa cttcagagaa tatttttgcc 3841 ttagtatatt gtgtaatgtc atgagttact gtaaatgtac cataagcacc tgaaccttta 3901 gcatgcattc ttctttcagg tataacttct ctatcaaaat gtgccatctt ttccataaac 3961 catacatctt gtaaaagcat aggtcctctg gcacctgctg tcatagaatg ctgattattt 4021 tcaaccggag caccgaattc agttgttaat tttttatctg acatattaaa aactccttaa 4081 tagtatttat tatcaataaa tatattatac taaataaata ttttatttca agtctattga 4141 taaaaattat tataaaatat taataaatta ttaataaaaa atattaaata ataaaaaatt 4201 gaaacaagta ttgactaata attaaaaaaa atatatattt aataataaat attactaata 4261 aggattatat attatgagta acagaaaaga gacaactata cttctaaata tgggaggacc 4321 tagaaatttt gatgaaataa atactttttt agtaaatatg tttaatgatt attatatact 4381 caatataaaa aatagtttta taagaggtat gatagccaaa aagatagtaa acaaaataaa 4441 acctgatgta ataaagcatt atgaagctat aggaggaaaa tcaccaataa atgaatatac 4501 tgaaaaactt ataaataaat taaatgagtt agacaaatca aaagattata aatacataat 4561 gaactatact ccgccttatt cttatgatgt attaaaagag ttaaaagaaa ataatataga 4621 taatattaca ttattcagta tgtatcctca atattcagaa gttacagtaa aatcatcttt 4681 agaaaatgtt tataaagcta tgaaaaaatt aaaatataat cctaaaataa atataataga 4741 tagatactat gacaatgaat attataataa ttcagttgta aacttaataa agaatagtat 4801 agctgataaa aatgcagaag aatacatatt aatattttct gctcattcaa tacctaaaat 4861 gtatgctgat aaaggcgatc cttatgaata tgaatgcaat tataatgttc aagtattaag 4921 agaaaaactc aataatgcag gattaaattt caaagatatt gttctttctt atcagtcaaa 4981 aataggaaaa attgaatggc tggaaccatc aactatagat acaataaaaa aatatagcgg 5041 cgaaaaatta ataatatatc ctttagcatt cacaatagat aattctgaaa caatttatga 5101 aatagatatt gaatatagag aagaagctat taacaaatat aatattaaag attttatatt 5161 atgtccatgc ttaaatgaca atacagattt tgctgaaagt ataatagaaa tatcaaacag 5221 ttataacaaa cagaatttaa atattcatta taataaaaaa atagtttaaa aaatacatat 5281 aaccttttta tattcattaa gttttataat aagaataaat tttaaagtaa attatgttgt 5341 aataaagtat tttataatta aaatattttt actttcatta tttactttaa aattatttat 5401 gatataacat tacaagataa aaatatcgtt tctggagctt ttatgggaaa acttattgta 5461 aaactaaaaa ctatttattg tattataata atgtcattaa ttttaacaat gataacagga 5521 gttagtatgt ttgcagcggt agctatagat agaactactc caatagggga aaatacaagc 5581 agagcaaatt atgaagcaat aacagttaca ttcaatcagc agatggtcgc tttgcaggct 5641 attaaagaag taactaatca atacttcaat tttaatgtag atgttaaagg tacatataaa 5701 tggctatcta ttaatacttt agcattctat cctagcgaac ctttaccaga taatacagct 5761 attgaagtta cacttaaaaa aggaataaaa agcgaactta caggcgatat attagaaaat 5821 gattatactt ggacttttaa tactttaaga cctataatgc agaaaagttc tccttatgac 5881 agacaatcag aacttcctac agatgttaat atagttgttt attacaatat gcctatatat 5941 cttcaaagtg caaaagaaaa aatacaatta atcgcaagca ataataatac tgctatagat 6001 tttgatgtaa gatatgcaaa aatagaagac ttaagagaat gggaaactaa ttcatatgag 6061 ttagaacagg tattagttat aaaacctaaa aaagctttag ctaaaaacga tgagataaca 6121 gtatatatag aagagggact tgctgctgtt aatggtaatt taggcacagc aaatagttca 6181 agttttaatt tttctataca tgatgaattc tattttaaag gaaacagtga acaaacagta 6241 acagcatcat attctcctga agctcctaaa ttagagttta gtacaagagt tgaatgggct 6301 gacttaataa gaaatatgga aatcactcct gaaattcaac ttcctacaga agaagaaatt 6361 cagcagaact cttggtcatc taaaagtttt tcactttatc aattgagatt caatccaaat 6421 gttacatata atataaaaat caacggaagt ttaaaagact cttacggaca gactttggct 6481 caagaacaaa atatcacttt aaatgttact gattataacc caagcgtttc tataccttca 6541 ggaatgggag ttgttgaatc ttatgaagga ataaaacttc ctgtacaggt aatgaaccct 6601 aatactatta atatacaaag cagatatatt gacaaagaaa atatcatacc tttcctattt 6661 gtaaataagc aggtatacag atatgatgaa actcctgaat ttagaagata tacaaatcag 6721 tataaaaatt tattcggata caataatact tcagaatata ctccggacgt tgaaagaaac 6781 agatatatta caacagcatt atatttaact aattatatgg acaataaaca gtatggactt 6841 ttatctataa agtttgatag taaaacagga tatcaaagtc agtacgatta ttctacatct 6901 tcacagatac aaataacatc tatgggatta acaggtaaat tctcaggcga ttcaaacact 6961 atatttgtaa ctgatttaaa aacaggaatg cctgttgaag gagctgaagt agaaataaga 7021 gatgatttca acagagtttt agcaagagct actacagatg aaaatggaat agcaactact 7081 aaaggcttca gagaattagg aataaaaaga gcaagcagat gggatacacc aagacaatgg 7141 gctatagtta caaaaggcga tgatgtatca ttcataaata gtgattgggg tactggtgtt 7201 tcaccttgga gaatggatat aagttatgat tattcacctg ctgatagaga ttataatggt 7261 tctatgttca cagaaagagg actttataaa cctggtgaag aagtacatat aaaaggtgtt 7321 ataagagaaa atatattagg aaactggaaa atagctagag atttcaaaac aggattatac 7381 actgttaata attcaagagg agaagaaata cataaaggaa cagttacttt aaatgaatat 7441 ggttcttatt taattgactt cactcttcct gctgatgctc ctacaggata ttacagtgta 7501 aatgttgaat tcaaaagcga ttcaaataaa caaagcgatg aagaaaaaca agaaggcgta 7561 aaagatcaaa catatagttt atctcaaagc ttcagagtag aagaatttaa acctttagaa 7621 tatgaaagca gactttgggt tgaagataag aattattatt taggcgacac tatgcctatt 7681 aagatgtcag gctggtattt attcggcgag cctatgatat ctaatcaagt agattataat 7741 atatctatga atgaaacttt cttcactcct cctaataatg caggattcag attcactaaa 7801 ttgagctggt ttgaagatga gtattataat aattattatt ctatgatagc aaatggtaca 7861 ggtgcattag atgaaaacgg tgaatatgct tatgctccta ctatagatgc aagccgttca 7921 atacatgctg cttatgttac tatagaatca actgtatcag gtgaagattc tcaaagagta 7981 agcacaacta aaagcgtatt agttcatgga agcgattatt atataggtat aaaaagacaa 8041 ggctatttct tagaaacaga taagcctaca caattagaat tcattgctgt tgatcctgaa 8101 ggaaacagac ttgaaggcaa aaaaatagaa attcaagtta taagaagaca ttgggaatct 8161 gtaagaaaag ctataacagg cggaagattt gaatgggaat ctaaacaaat agacgatgtt 8221 gttgaaacta ctacagttac aacaaaaaaa gatcctgttg cctacagctt tactcctaca 8281 aattcaggac tttacataat attagcaaga gcaaaagact ctaaaaacag agaagttgct 8341 tctgatgaat atatgtatgt tataggtaaa gattatgctc cttgggctat gttcgatgat 8401 gatttgttag agcttatcac tgaaaaagaa gaatatcagc ctggcgaaac agctaagata 8461 atgataaaat ctccttatga atctgctact gctttagtaa cagttgaaag ggaatatgta 8521 atagattctt atgttacaaa tattgaaggt tctactgctt taatagaagt acctataaaa 8581 cctgaatatt tacctaatat ttatgtaggt gtttcacttg ttaagggaag agttgaaaat 8641 gaagcatata ctaattatgc tactgatgag ggaaaacctt catttaaaat aggttatgca 8701 ggactttcag tatcgcctcg tgaaaaagaa cttaatgtaa aaataacaaa atctgctgat 8761 actttagagc ctcgcgatga aatgacagta gatttatatg tagaaactaa agaaagccag 8821 cctatggaaa cagaaatcat gttaagcgtg gttgatgttg gagtattaaa tttaataggt 8881 tacaaaactc ctaactggtt caatactttc tatggacaaa gacctttgag tgtagcaagt 8941 gccgacacaa gaatacactt aataggacag agaaactacg gagagaaagg agatactcct 9001 ggcggcgatg gtatgagagc tgctaatgat atgatggcta aagctgaagc tatgggtatg 9061 gacgtattca gcataagaaa gaatttctta acaactgcat tctatcaagg aagagtaaaa 9121 actgatgcta atggtaaagc tactgttaca ttcaatttac ctgataatat tacatcattt 9181 agaataatgg cttctgctat aaataaagat ggttatttcg gtgcttctga tgatgttgtt 9241 gtagttaaga aaaatatcat gcttatgcct accctacctg aatttgctta tgttgaagat 9301 aaattcaaag ctggaagtat agtatacaat tattctgatc aggatttaga aatagaagtt 9361 caggctgttg cttctaatgc tacaatagaa aacgcatctc aaataattac tgtccctaaa 9421 ggcggtaatg ctgatgtaag attcgatatt atagctacaa acagaggaga ggctaaagtt 9481 acaatacttg ctaaaggcgg agaatatact gatgctgtag aaaaagcatt tgaagttaat 9541 attcctatga ctacagaatc tgttgctcta ttctcaagca ctacaaataa caatactgat 9601 ttaatgctta gaatacctaa tataacagaa gcatataaag gtgccggaga tttagaagtt 9661 tatatgtctc ctagtgcatt cagcgaactt acaggcggta taaattatct tataaattat 9721 ccttatcttt gtttggaaca gcagttatca agagtttatc ctataataac aagtaagaga 9781 ttattagtag acatgaagct tactgatata tctgaagaaa atctagataa aacagttcag 9841 gatttcttaa aaatgatgcc tacatatcag agtcctgacg gaggattctc ttactggcct 9901 agcaaaactt gggtatctcc atggcttact gcttatgctg ctgatgctat gattaaggct 9961 aaaaaagaag gatatacagt tgatgaaaac tctttaaaac tagcattaga atacatcaat 10021 aattatgcta agagcggaaa tgctgaaaaa cctagcttct ggcaggatga atatatcaat 10081 ctttcatcta tagcttatat tgcggctgtt ctttctgaag gcggatacaa tgctaatgat 10141 gtaaaagcta taatagacag aatatatcct caagttaata atataccttt ctacggacag 10201 gttcaattaa tgagagctat gtactataac aaatatgata ataaagcatt aactgaagtt 10261 agacagtata tacttaatac tattaaagaa gatcctaaca cagcacatta tgagcttgaa 10321 gcatattatt ctaatcttta ttggatacac tcttcttcag tgagagatac atctgttgct 10381 ttatatgctt taatagaaac aggatatgac aatgctataa atgaaaaagt agtacgctgg 10441 ttagttcagt caagaaaaaa cggcagatat ttaaatactc aggacaatgt ttcagtattt 10501 gctgctatga atatgtatta taaaaaatac gaaaatgtta aacctaattt caaagcagag 10561 tttatatatc aaggtaaaac tttacttgaa gaaacattta ctgcaagaac tcagcctagc 10621 ctaactaaaa aatatacttt agatgagttt atgaatgaaa gattaagtaa ttcaaatact 10681 agatctgctt tagctaacat aaaacgcaat ggagacggaa gactttatta tggtgttaga 10741 cttacttatg cacctcgtga attagcagtt aatagagata tgggtataaa agtagaaaga 10801 agatacgaaa ctaaagacgg cagagtatta gacttaacta aagataaatt caagcaaggc 10861 gaagaatatg ttgtagtagt taaagttaca gctccttatg aaagacattt tgttgtagtt 10921 gatactccta ttgctgcagg tatgagaata ttgaatgcta gctttgctac agaaagcagc 10981 gaagttaaaa acttaactgg aaatgccggc aaacctactt ggtggtgggg cggattcaat 11041 catactgaaa actataatga caaaatatta ttgtttgctg atatgcttag tgacggcgaa 11101 catgaatata gatatgtagt tcgtgctgtt actcctggtg aatatttact tcctgctact 11161 aaagctgaag agatgtataa ccctgaagta tttggttatg acggacagca taaagttgtt 11221 atagaaacta aataaatcta aacaataatt ttataaaatt aaaggtggta tcttttttga 11281 ggtatcgcct tttttatatt aaattaatat taaacaatga aattattaaa tttgtatttt 11341 ttgaagtata atattatcag taattttttt gaaaataagt ttatatatac ttaaaatttt 11401 taagtttgtc aattttttta ttgttctttt tccaaccgta cggatagcta aacaataaat 11461 atatattaat ttgaattcta atttttacta tatttgaaat ttcgctcacc gtgcgtagag 11521 taaagtttta aatttaaaaa aatcttgggc gggtgctgaa atttctaatg aagctataaa 11581 tataatgtaa atagaattac agaaaaaaat ataaaggata aagggaggga attgtaaata 11641 aatcaaaaaa tataattcat aaaaaatttc ttgattaata tataattagc tatattatat 11701 ttgcaataaa atttaaaaaa taatattaag gttacaaaat gacatcagaa aataagcata 11761 ttataataag cggtgaatta gcattaattt tagttgtggt tatgaatagt tttggagttg 11821 tattaatgct ctactcaggt tctggaatat ctgctatatc aagtgtgcct tatgcttttt 11881 ctgaagttat aaaaaatata tcgcttggaa cttttacata tatttttcaa accttacttg 11941 tattagcact tatgatatta agaaaaaaat ttgtaggaga atatttattt agtttcgttg 12001 taggattttg tttcggtaag ttcgtggata tacatgctgc ttggataaat catcttccat 12061 taacaataac aagcagaata atatatttca taataagtta ttttatattg gcattcggaa 12121 tagctttatc aaacagatgc ggacttccta taataccaac agatttattc ccaagagaat 12181 tatcagatat aataaaaata ccttatgcaa aagtaaaaat aacattcgat gtaatttgcc 12241 tcttaacaac agcaatactt acatttgttt tcttaggtca tataaaagga cttggaatag 12301 gtactgtact tgccgctttc acgatgggta aatctatttc ttttataggc aaacttctag 12361 ataaaaaaat agaatttata ccgtatataa aaaaactatt gcataaagaa aataatgcat 12421 gaatttaaaa tttttcattt tcatcattag atattattct aacttcagca tttaaagtta 12481 tgcctttctg attataaact tcttccctta cttttctcat aagatttaaa atatctcttc 12541 ctgtagcatt attataattg actataaaat ttgcatgata aggagaaacc atagcacctc 12601 ctaacctagt tcctctcata ttaattgaat ctataacctt acctgctatc atattagttt 12661 cataatcatt caaaaaagta cttccggcag aaggatattt aaattgattt ttattctttc 12721 tgtctttata aaactttttc atctcaggct taatcaattt ttttgagccc ttatttagtt 12781 taaatctaac atctacaatt acatatttct tatcctgaaa aatacttctt ttatatgcgt 12841 actcacaatc ttcaacattt atatgcatat attcaaaatt atcatctatt ataccaactt 12901 tatctataaa ctcggataca gaatgttcat aacatctcgc attcatataa gcagcacctc 12961 ctatagtacc aggaagtcct gataaaaact ctaaacctgt gaaagcattt ttataagcat 13021 atttaacaac atcagaaact ttggctcctg aatatgctaa aatattatga gatgtatgct 13081 ctatacgaga aaaaaatccc atatgaataa ttggaaattc tataacttta tccaaaaata 13141 atacattgct tccacctcct aaaatcatat accttttatt attatcatta agatatttaa 13201 tcaaatctat aaaaccatta atagtctcag gcatataaaa ttccaaagcc ttagcactaa 13261 ctctaaaagt attaaatttt tttaaagaaa cattctcttt acttaaaaca ccattaaaag 13321 atttaaccat ttcaataatt cctaataaaa tatttatata aataaaacta ataaaaacta 13381 ttaaagtaat tttataaatt ataccaatga ggtttttcta tcaaagaagt atttacaaac 13441 atatctttaa tatccgcatc tttatttatt ttccaatcat tcaaatcctg attaaaatta 13501 taagcattct taaacataca agtcatagat tttacattac taacgttcca tttattcaat 13561 ggatgattaa aattttccgc tccaaaaaac atataagcca tatcagtaac attagaaaca 13621 ttccaattat taatatctat attaaaattc tttatattat gaaacataga tctcatatta 13681 atgacattag aagtatccca tttctctatg ccagaaaaat ctatcctcac attatagctc 13741 tcatattcac tataggagcc ttcaaaacat gcaaaattag gcttatcaaa aagcatagac 13801 atatctgtta tcaatgaagt atctatatct cctaaatata tattattatt ttctattaaa 13861 cttcttaatt caattttgtt tgtaggttta tatttactca taatttttaa ttactttgat 13921 tattttcttc tgaagaatta ttttcagtat tttcattact ttcagctata ggcgcttcat 13981 tattagaaac ttcttttgca tcatgatttt cttgttcttc ctgatctgtt tcttctactt 14041 taggcataaa cttttcatct cttttaaata cataaatctc tttgaacttc atctcttgtt 14101 taagaagaat ttctttttct ttaacaagtt caagcatagc taaaaagaat gtaacaagct 14161 gccttttagt aactccgtct ttaaataaag taataaaagg aaagaatgct gtttcggata 14221 attttattct tatcatatca atagcattat ctatatggaa attagacatt ccagaaagaa 14281 ccgccaaatc tgtttccgga acaaactgca ccttagtgaa tgcataaacc aaatcataaa 14341 gcgtaatatc cttccaagct acctcattat catctgtatt tacagttttg aagaatttta 14401 ctctttcagt atcctttctt tcaaatatag tatctgatgt atcctgaagt ttatcaagct 14461 cttcagaaac cattttatat ctttgaaatt caagcatctg ctcaactatt tcaaatttaa 14521 gcttatctgt aaatttatca tcatccatat catgaggaag aagcatttta gacttataaa 14581 gatgaaactc tgaagcaaca actaaaaagt ctcctgtgga atccaaattt aaagcagcct 14641 gagccttcaa atattctaca aactgatcta taatttcaag tatagatact tcatatatac 14701 ttttctcact tcttttaagc atatcaaaaa gtatagataa tggcccttca taatctatac 14761 tagataatga aactgtaaac tccttataat ctggtttact gttttctgtt tcttctttgg 14821 ctgaagtgtc tgcatttata gcattattat tttcttgctg tgtttcgttt atattctctt 14881 ccataatgga ttataatata ttataaaaat ataaaaattc aagtatataa ttttcaatta 14941 atattgacaa taaatgaaat tctaatatta tttaaacaat gaaacaatat aaaaaataaa 15001 atatttaata aggggtaata tatgaaaaaa ataaatatag gttttatagg tgcaggtaaa 15061 atagcagaaa aaatggcaca aactatttca aaaataaaag aagcacaatc ttatgcagta 15121 agtgcaagag atataaaaag aagcaaggca tttgctaaaa aatacggatt caaaaaattt 15181 tacggctctt atgaagaaat gctaaaagat gaaaatgttg atttagtata tatagcaact 15241 ccgcattcac atcattatga acatataaaa ttatgtttag aaaataataa aaatgttata 15301 tgtgaaaagg cttttactgt taatacaaaa caagctagag aagttttaat acttgctaaa 15361 aagaaaaaac ttttacttgc tgaagctatt tggactagat atatgcctag cagacaaata 15421 atcaatgata ctataaaaag cggtataata ggaaaagtta cttcattaac tgctaattta 15481 ggctatgtta taaataaagt acctagatta atagaaccag aacttgcagg aggagcttta 15541 cttgatgttg gagtttatac tataaatttt gctttaatgg tatttggtaa caaaataaaa 15601 aaaatagatt ctagctgtgt aaaaactagt aaaggcgtag atgaacagaa ctctattaca 15661 ttaacttttg aagacaataa aatggctata ttaaattcta caatgtcagc attaactaac 15721 agagaaggcg ttataaatgg cgataaaggt tatatggttg taaaaaatat aaataatcct 15781 gaaagcataa ctgtttattc attagacaga aaagttgtaa aaacaataaa agtacctaaa 15841 caaataagcg gttatgaata tcaaataatt tcatgcatca atgctattaa taacggcaaa 15901 ttagaatgcg aagaaatgcc tcatgaagat attttgagag taatgaatat aatggatact 15961 ttgagaagaa gctggaaaat aaaatatcct tttgaaaaat aattttattt aatacattaa 16021 taaaataaaa gccgctaata ttttttatat taacggcttt tttatttata tatatttttt 16081 aattaatatc ataaacatat atactttctt ctatatcttc atcatctatt ttcaaagtat 16141 tttttgtacc ggaatcttta aatccgtttt tctcataaaa ttttttagca tcttcatttt 16201 tctcaaaaac acaaagacat atattggtat atccagactc tttcatgtat tttacagcct 16261 gttccaacaa caatttacct attccagaac cttgatatat agggtgaaca tataatgata 16321 taatctctcc atatccttcc atattgcatc tgctttttcc atgagatata acagctatag 16381 gctttccatc aatataagct aaatgtgcct ctcttgtctt attattaata ccctcctcaa 16441 actcctcgca ccaatcatct aaatatattc ttttaagata tgaatcaggt ataatatttt 16501 tataagcatc tttccagcat atagcatgaa gtttgcttat atcaaaaaca tcttctaatc 16561 ctgctttttt tatagttata tccatttaat tatacctctg cattttaata ataatcatta 16621 ctattaaata aattatatat ctataataag ttattttcaa ttatttattt ttatttttga 16681 taaaaaatta caaagtgctg agatttctta aagcattgct tatcaaatct tctgtagtca 16741 tattatcttt attttctatt gcagacaaag ccttaacagc ttcattattt gaaaaaccta 16801 atgatatcaa agcttttata acatcgcttt cattatcatt actaataaca gacggtgaaa 16861 tattgatatc tatcttttct atcttatccc ttaactcaaa taaaagtttt tctgcctttt 16921 taactcccat accggatact ttttttagta aatttatatc cttattaaaa agtatatgca 16981 tcaaatcatt tatagaataa gtagaaagaa cttccatagc caatttagga cctacccctg 17041 aagcagacat cagagtagtg aacatatttt tttcttctct agttaaaaaa ccataaagta 17101 tcatagcatc ttctctgtgt ataagtttgg tataaagcct tatattatca tcatttttta 17161 catctaattt ttttgatact ataatctcat agccaacacc attacaaaga agagcaatga 17221 caccttctga tattatttga actttacctt ctataaaagc aaacattata aactaggctc 17281 gtattctaat tcttttatag tttcaagcat tttatctgta gttactttag attcatcata 17341 ttctacttca gcacaagcat tttctaaact tacattaact ttgcttatac cgtctaaagc 17401 acttaattct tcagtaactg ctttaacaca attttgacag cccatacctt ttatttttat 17461 agtaatattt ttcattttag tactcctttg ttataattat ctaacaatta tatactacat 17521 aagggtattt ttcaattatt tttttctatt ttttcaatat ttttagattc ttcttcttta 17581 tacaaattaa atacaacagt catttctgta ccgacattct cttcactttt aatatgaatg 17641 tcagcattat aataattaca tatatttttt actattgtaa gtccaagacc tgtaccatga 17701 actttcaaat atttattatt tttaactctg aaaaatcttt caaaaaccct attcaaatac 17761 tgaggtgcga taccgcatcc tgtatctttt actgaaaata tagctttatc agaattattc 17821 tttaaatata tctttacttt accgtcatca tcagtatatt ttatagcatt atcaactaaa 17881 ttattaacta cttcagtaat tttctcttta ttagccatta taacagcaga ttctatatct 17941 aattctacat ctatatttct ctgctcggat tttattctat tgctttcaaa tacatcaaga 18001 acaatatctt ttatgtctat ttcttcatca acagtttctt tccaattagc ttctattctg 18061 ctcaatgtaa gcatatcaat aactaaatct ttcattctta aagcttcatt atttattctt 18121 tttataaaat ctgcctgatt ctttccgcct cctgtagcaa taagaagttc agaatatcct 18181 attatagaag tgagaggagt ttttaattca tgggaagcat ttataaagaa gtcctgcttt 18241 tctatctcaa cctttcttat atctgtaaca tcttcaaatt ttattaatgc agatatattt 18301 tcattatttc ttataggtat gatgcttatt tctatatcca tagtatgttc tttaacatca 18361 aattttgaaa atctgctgaa ctctatggca ttatctattt tttctattac atcatcatct 18421 tttattattt cattgagttt tcttatattg ctgtcagaaa tttcaagcaa atctaaagca 18481 tactgattaa taaaaaatat ctccttattt ttattaacag ctataatacc ctgtgctata 18541 ttctcaagta cataattaag cttttctctt tcagtctgat aacctgtgat attttcattc 18601 aaactaacag caagttcatt tatatcataa agaatagtat ttatatcatt gtatcccgtt 18661 aaatttttag gtgtcggaga tttattatta tatatattat ccagggtttc ttttatcata 18721 tagaaaggaa tcataatatt acggctcatc aaaggaagaa ccaaagccat aattataata 18781 actataccta taaccattac ggctgtaaat aagaagctta tcaaatattt attaactgac 18841 tctataggaa ttgaaactct aagtatataa tctcttttat catcagcttt aatttttttg 18901 gatacataca tataaggagt tttctgacta atagaggtat ttatagaaaa agccggctta 18961 ttttccatac tatgcaatgc ctctataaca tcgcttctat ttgtatgatt ccccatagga 19021 tttttagagg tatctgtcat cgtatcagct actacaaccc catttgtaga tattatgctg 19081 attcttaatt cttctttatc tgactgcagt acaaattttc taaaagcatc ttcagtttgc 19141 acatcatata aatcaatctc tttttcaagc atttccataa tatttactat cataacctga 19201 ctgtacataa tattattata ttgcacagta aacagtatac ctataaacat taaagcactt 19261 gataatatca a //