LOCUS NC_010674:4 18937 bp DNA linear BCT 25-AUG-2011 DEFINITION Clostridium botulinum B str. Eklund 17B, complete genome. ACCESSION NC_010674 SOURCE Clostridium botulinum B str. Eklund 17B, complete genome. COMMENT locus start: 311378; locus end: 330314 FEATURES Location/Qualifiers source 1..18937 /organism="Clostridium botulinum B str. Eklund 17B, complete genome." gene 0..197 /gene="" /locus_tag="" /db_xref="311378..311575" CDS 0..197 /gene="" /locus_tag="" /product="hypothetical protein" /translation="VSSIETFPIYDDVDIPNIETFPMDESDEMDNIIFIDGVTQAKNL NIPKSVARQVKKTFTRSKEEL" gene 253..381 /gene="" /locus_tag="" /db_xref="311631..311759" CDS 253..381 /gene="" /locus_tag="" /product="hypothetical protein" /translation="LGGDRSGQRAIDIKGIGQGRIVYETNSDGGIDIIQILTKNDY" gene 397..717 /gene="" /locus_tag="" /db_xref="311775..312095" CDS 397..717 /gene="" /locus_tag="" /product="putative erythrocyte membrane protein 1" /translation="MKMKHVLLEMYCSLKSDNEKPTYCEGVGHICIHNKCEYMGCTYC PNEIAYANEHGVVEDELDFVGFGGDMNGNDDNKTKELIEKWNKICRKKIDEAYEEYMD YRNS" gene 983..1342 /gene="" /locus_tag="" /db_xref="312361..312720" CDS 983..1342 /gene="" /locus_tag="" /product="hypothetical protein" /translation="VNIEFLEDKLRSYEFKYPESFLKAIKLNLVDFDLWYIMDEERAI NRLKGLKERYPNRKLIPFARRDDNDDIACFEANKGERVQIIHDFASVGYEQRKEYNCF WDWLTEAIKVMIEYNKE" gene 1475..2536 /gene="" /locus_tag="" /db_xref="312853..313914" CDS 1475..2536 /gene="" /locus_tag="" /product="internalin-A" /translation="MKILFSDKQFEYEIRKKIRKLSGDIEVEDLKSIIELKIIHYSDK PQIASLEGIQYCDNLRKLELMGTYLNDIFLIKNIKKLEYLDLSDNNIKDISFICNIKT LKYLNLSGNPIKNIDYINDIRSLERINLERTDCEVPNLSNPDKIISFGLPQNCFDLEF LNRYKNLKEITLPSCLKTLEVIKEFKNLHNVESLSINNSKVSDLTPLSNLKRLKKLDS FANNLDDISPIYNLKELISINVGINKISDISCIESLINLEYFIAEQNLIKDIVPLKNL FQLKELNLSGCRVSDISPLEKLKKLEILNLEDNLLTNINGIEKLDKLKEINLEYNEIN DIEMLRKLQEKRNDLEVIY" gene 2819..3232 /gene="" /locus_tag="" /db_xref="314197..314610" CDS 2819..3232 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MNIVPYNEYLLVMPNGDTKGFDDLELAKAYINIYYERVIDHKID KDDYNDATEIGAEEPRRNICTQLGVAEGRCEVYSIDNFIEVIRNNLVFDDEREEIISK LLAKEISFNVYDYNLDTILVDIESIDMMEPYGDAD" gene 3607..4116 /gene="ilvN" /locus_tag="ilvN" /db_xref="314985..315494" CDS 3607..4116 /gene="ilvN" /locus_tag="ilvN" /product="acetolactate synthase, small subunit" /translation="MRKYVLSVLVKNSSGVLSRVSGLFSRRGYNIDSITAGRTEDPLV SRMTITLSGDDDVLEQVKKQLNKLEDVIRVINITSDDSVYRELVLIKVKASGDERAAI NETAKIFRCKVVDVSPNTLTIELTGDENKISALIKLMEEYGIEEMVRTGITALQRGIS TIKNSIDEC" gene 4290..5549 /gene="leuC" /locus_tag="leuC" /db_xref="315668..316927" CDS 4290..5549 /gene="leuC" /locus_tag="leuC" /product="3-isopropylmalate dehydratase, large subunit" /translation="MGMTMTQKILAAHAGLESVKAGQLIEVNLDLVLGNDITTPVAIN EFKKFGVDKVFNKSQIAIVPDHFTPNKDIKAAEQVKYVREFSNKMGIENFFEVGEMGI EHCLLPEKGLVVAGDVVIGADSHTCTYGALGAFSTGIGSTDMAAGMATGQTWFKVPSA IKFILKNKPAKWVSGKDIILHIIGMIGVDGALYKSMEFVGDGLNYLSMDDRFTMANMA IEAGGKNGIFPVDDKTVEYLKEHTKKEWEVYKADEDAEYDEVIEIELNTLRPTVSFPH LPDNTRTIDNVGDIDIDQVVIGSCTNGRISDLRIARDILKGKKVKKGIRCIVIPGTQN IYLQALEEGIIKDLIEAGVVVSTPTCGPCLGGHMGILAKGERCVSTTNRNFVGRMGHV ESEVYLASPAVAAASALTGKITDPELV" gene 5564..6049 /gene="leuD" /locus_tag="leuD" /db_xref="316942..317427" CDS 5564..6049 /gene="leuD" /locus_tag="leuD" /product="3-isopropylmalate dehydratase, small subunit" /translation="MNVKGRVFKYGDNVDTDVIIPARYLNTSNHKELASHCMEDIDKE FVNNVKDGDIIVANKNFGCGSSREHAPIAIKAAGISCVIASTFARIFYRNSINIGLPI LECDEAVKNINHGDELEVDFSTGIIKNLSKNEQYQGEAFPEFMQKIIDNDGLIGYIRN K" gene 6221..7303 /gene="leuB" /locus_tag="leuB" /db_xref="317599..318681" CDS 6221..7303 /gene="leuB" /locus_tag="leuB" /product="3-isopropylmalate dehydrogenase" /translation="MKYNVAVIPGDGIGPDIVTEAVKVLNVVGEKFGHKFEYEYVMAG GCSIDKNGEALPKETLDICKASDAVLLGAVGGPRWDDPDSKIRPEQALLGLRSGMNLY CNLRPAVLYEPLKNASPLKDEMVKNGIDIAIVRELTGGIYFGERGRDEIDGIESAYDT ERYSTVEIKRIVKIGFKTAMKRNKKLTCVDKANILETSRLWRKVIGEISKDYPEVNVN YLYIDNASMQLVKDPTQFDVIVTSNMFGDILSDEASMITGSIGMLPSASLGEGTLGMY EPIHGSAPDIAGKGIANPLATILSAAMMLRYSFDLESEAKLIEGAVLSVLEDGYRTGD IMSKGKIKVGTNEMGDLVCKKINKGE" gene 7310..8968 /gene="ilvD" /locus_tag="ilvD" /db_xref="318688..320346" CDS 7310..8968 /gene="ilvD" /locus_tag="ilvD" /product="dihydroxy-acid dehydratase" /translation="MKSDAIKKGPGKAAQRSLLKALGLTNEEISRPIIGIVSSQNEII PGHMNLDKITEAVRKGILMSGGTPLAIPTIGVCDGIAMGQEGMKYSLVTRELIADSIE CMAKAHAFDALVLIPNCDKIVPGMVMGALRVNVPSVVISGGPMLAGKYKGKDISLTTM FEAVGSYENGTMDEKELCDLEECACPTCGSCSGMFTANSMNCLCEVLGIALPGNGTIP AVFSERIRLAKRAGMAVMDMLKNDIKPRDIINEKSIMNALKADMALGCSTNSVLHITA IANEAKVNMNLDIINDLSSKTPDLCKLAPASNVHIENLYAAGGITAMMNELSKKDILD LDCITVTGKTQGENIKGVTVKDYEVIRPIDNPYSKNGGIAILRGNLAPDGAVVKRAAV LPEMLVHEGPAIVFNSEEEANEAIFNKKINPGDVIVIRYEGPKGGPGMREMLQATAAI AGMGLDDSVALITDGRFSGATRGASIGHVSPEAASGGMIGLIEDGDIISIDINNAKLE VKLSYEEIQRRKLKFKPIEPKVKEGYLARYAKLVSSASEGAILK" gene 9055..10728 /gene="ilvB" /locus_tag="ilvB" /db_xref="320433..322106" CDS 9055..10728 /gene="ilvB" /locus_tag="ilvB" /product="acetolactate synthase, large subunit, biosynthetic type" /translation="MLLTGAEILIKSLVDEGIDTVFGYPGGAVLNIYDELYKYKEKIR HVLTCHEQAAAHAADGYARATGKVGVCIATSGPGATNLVTGIATAYMDSIPMVAITGN VAKPLLGKDSFQEVDITGITMPITKHNYIVKNIEDLQEVIREAFYIAEEGRKGPVLID IPKDITSNKTEYKKLIPKKITREIDEIKEDSFNEAINYINNCKKPFIYAGGGIVSSEA TEELIKFSEKIGAPVSTSLMCTSEFPFDHNLYTGMIGMHGTKASNIGATQCDLLIVLG ARFSDRVISDQNHIKNAKIIHIDIDPAEINKNIKVNSSIIGDLKYVLNKLIPLVEKKE SKDWINFIDSLKGKKHIDGINSGELTPKFLFDNLNKLNDGSFIITTEVGQHQMWASQY FNYTNRRSFLSSGGLGTMGYGFGAAIGAQIGKPDKKVFNIAGDGSFGMNCNEMATAVK NKLPLVVIVMNNNALGMVRQWQTLFYEKRYSETTLDRQTDYVKLAEAFGAKGFRVEKR ENLEEVLKKAIASKEPVLIDYVISNDKKVFPMVAPGAPINQLISEEDIN" gene 10750..11766 /gene="ilvC" /locus_tag="ilvC" /db_xref="322128..323144" CDS 10750..11766 /gene="ilvC" /locus_tag="ilvC" /product="ketol-acid reductoisomerase" /translation="MTKMYYEEDTDLNLLKGKTIAVIGYGSQGHAHALNAKESGGNVI IGLYEGSKSWAKAEAQGFEVFSTAEAAKKADIIMILINDELQAAMYKKDIAPNLEAGN MLMFAHGFNIHFDQITAPNDVDVTMIAPKGPGHTVRSEYQLGKGVPCLVAVHQDATGR ALETALAYANAIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETLVEAG YDERNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGSKIITEETKKTMK KVLKDIQDGTFAKDFLLDMSEAGGQAHFKAMRKLAAEHQSEAVGSEIRKLYCWNNEDK LINN" gene 12616..12873 /gene="" /locus_tag="" /db_xref="323994..324251" CDS 12616..12873 /gene="" /locus_tag="" /product="GIY-YIG domain protein" /translation="MNYVYILECSDNTLYTGWTNDLGKRIKMHSLGKGAKYTRGRTPV KLVYYEIFEDKNEAMRREYRIKRLIRSQKEALIKTFDCALL" gene 12917..13915 /gene="" /locus_tag="" /db_xref="324295..325293" CDS 12917..13915 /gene="" /locus_tag="" /product="transcriptional regulator, LacI family" /translation="MKVTIKEVAKEANVSTSTVSRVLSDSSQISEETKSKVREAVKKL KYKPNAIARSLANNKTRIIGVILPNEAQDLLTNPFFIQAMKGMSVYAQSKNYYITYAF SKDEAHEAHHVNDFINSNLVDGICLLRAKSDDDNIRYLKETGFPFVVIGRPEETDGIL WVDNDNFKATYDLVNDLVKRGKKKIAFLGAREEWNLTKDRINGFKVSCQMNGINIKEQ DIIIKEEFTEQEGIEATNELLKLGIPDAIVAEDDMLAFGSLKVFKEKNLKDISIIGFN NTQLAEFQNPPLASVDINAYELGYYAAKILIDSLENNNNMDHYIIDTNLVVRDSIK" gene 14226..15890 /gene="" /locus_tag="" /db_xref="325604..327268" CDS 14226..15890 /gene="" /locus_tag="" /product="glycosyl hydrolase, family 13" /translation="MKKIWWKEAIGYQIYPRSFKDSNGDGIGDLRGIISKLDYLKELG IDVIWICPMYKSPNDDNGYDISDYQDIMEDFGEMADFDELLTKVHKRGMKLIIDLVIN HTSDEHKWFVESKSSKDSPKRDWYVWKEGKDGSEPNNWESIFKGSAWEYDENTEEYFL HLFSKRQPDLNWENPEVRNELYKMVNWWLDKGIDGFRVDAISHIKKDQTFEDIKSKSN ERYVSSFEKHMNFPGIHRFLAELADNTFENYDIMTVGEANGVDSEEAELWVGEEDGKF NMVFQFEHLNLWDYDSENKLLVVGLKKALTKWQNNLNGVGWNALFIENHDIPRVISTW GNDENYRRECAKALGLMYFMQQGTPFIYQGQELGMTNVKFENINKYDDIKSINIFNER VECGVSKEEALKEIWAISRDNSRTPMQWNDSENAGFSNNKPWIDVNSNYKEINVESEL KDPNSVLNFYKKMIDVKKNSETLSYGEYKLILDEDENIYSYMRILGDKKYMIICNLSD NENLYKYEKETLTFESLILSNYEVNKHDKINSINLKPWECRLYKLM" gene 15952..17610 /gene="" /locus_tag="" /db_xref="327330..328988" CDS 15952..17610 /gene="" /locus_tag="" /product="pts system, iibc component" /translation="MKAKKEKLFSFEFWQKFGKALMVVVAVMPAAGLMICLGKLIGMS GDLALMQTIARVVEDLGWGIIGNLHILFAVAIGGSWAKERAGGAFAALIAFILTNRVT GAIFGVSSAMLADKTATVTSLFGKQLIVGDYFTSILGAPALNMGVFIGIISGFLGASL YNKYYNFNKLPNALSFFNGKRFVPFVVIAGSVVMAIVLSIIWPFAQSGLNAFGVWLAE SKDTAPILSPFIYGCLERLLLPFGLHHMLTIPVNYTELGGVYTILTGANAGHVIAGQD PLWFAWISDLINLKGAGDMSAYNNLLTTVTPARFKYGQVVLSSASLIGVALAMYKNVD EDKKHKYKSMFLSAGLAVFLTGVTEPIEFMFMFVSPILYGVYAVITGIGFALADIISL RIQAFGFVELLTRVPMFVKAGLSMDLVHFVISAVAFFFLNYCTFNFLIKKFKIATPGR RGNYIDSEEDESSQNASNTNTTGDELAVKIISLLGERENIIDVDACMTRLRVTVKDKV LVADEKDWKKNGALGLVVKDKGIQAIYGPKADVLKSNIQDILGV" gene 17615..18403 /gene="" /locus_tag="" /db_xref="328993..329781" CDS 17615..18403 /gene="" /locus_tag="" /product="endonuclease/exonuclease/phosphatase family protein" /translation="VKLLTLNCHSWQEENQIDKIKYLAKIISEKNYDAIALQEISQSI EAKVINNNLKVDNFAVLLKAELDKYNTNYNFFWDFSHIGYGKYEEGLAVFTKHNIVNE KSFFISKGTDREYWKTRKIVQVTFEYNNENIDLYSCHLGWWEDEEEPFKYQVKRLLEE NTSNNITFFMGDFNNNAFVRNEGYDYLVNKGLVDTFNISKEADNGITVKGNIDGWDEN KDKLRLDLILSNKKLDVITSKVIFNGTNKDVISDHYGVEISLNL" gene complement(18445..18936) /gene="" /locus_tag="" /db_xref="329823..330314" CDS complement(18445..18936) /gene="" /locus_tag="" /product="MarR-family transcriptional regulator" /translation="MHKQDLDKISDSLLTFLFLVKNNVFSENEFIKNFPKPPKEVEDY MNEFPMPPSHTKVILYLHKSSSSPISQIASNLGISKSNMTPIIDKLIEYGLVNRYPDS KDRRILRVELTAKALDIFEKFRNAAKAKLASKIEILDDDDLYALSDCVSKLYDIMQKI EKK" ORIGIN 1 gtgtctagta tagaaacatt cccaatatat gatgatgttg atatacctaa tatagaaaca 61 tttccaatgg atgaatctga tgagatggat aatattattt ttattgatgg cgttacacaa 121 gctaaaaact taaatatacc taaatcagtt gcacgacaag taaaaaaaac tttcaccaga 181 agcaaagaag agttatgata aagcaattga agcattaaaa agtggagata caagaggtct 241 tcatgatcat ccattgggag gagataggtc aggtcaaaga gcaatagata ttaaaggtat 301 aggacaagga agaattgtat atgaaacaaa tagtgatggt ggaatagata ttattcaaat 361 tcttactaag aatgactatt aaaaggaata agatgatatg aaaatgaagc atgttttatt 421 agaaatgtat tgtagtttaa aaagtgacaa tgaaaaacca acatactgtg aaggagttgg 481 acatatttgc attcataata agtgtgaata tatggggtgc acatactgcc cgaatgaaat 541 agcatatgca aatgaacatg gtgtggttga agatgaatta gattttgtag gttttggtgg 601 tgatatgaat ggaaatgacg ataataaaac aaaagaatta atagagaagt ggaataaaat 661 atgtaggaaa aagattgatg aagcatacga agaatatatg gattatagaa atagttaata 721 tatgaaacca cagatcatta taatacattt aaacaaatta aatagatgtc taggatgatt 781 aaatataaat aagattattt aagagctaat gtttctgatg gaagagatgt tagctttatt 841 tatatttaaa ttatactgag ataataaata caacacaaaa tgatataata agttcagcag 901 tagataaatg ttgggctcca gaagtaagtg gaccaagtat agaagtattt ctaatatatt 961 gtaaaaaggg taggtaagta actgtgaata tagaattttt agaagataaa ttaagaagtt 1021 atgaatttaa atatccagag tcatttttaa aagccataaa attaaattta gtagactttg 1081 acctatggta tataatggat gaagaaagag cgataaatag attgaaagga cttaaagaaa 1141 gatatcccaa tagaaaactt ataccttttg caagaagaga tgataatgat gatatagcat 1201 gtttcgaagc aaataagggt gaaagagttc agataataca tgattttgca tcagtaggat 1261 atgagcaaag aaaagaatat aattgctttt gggattggtt aacagaagct attaaagtaa 1321 tgattgaata caataaagaa taatataata gatgatttta taaatgcagg attctctaag 1381 aatacgataa atagagtttt agagcaacaa tacaaaatgt tagaatagca agtaactgca 1441 taaaatctaa acagagataa tttggagcaa taattatgaa aatattattt tcagataaac 1501 aatttgaata tgaaataaga aaaaagatta gaaaattaag tggagatatt gaagtagaag 1561 atttaaaaag tattattgaa ttaaaaatta tacactatag tgataaaccc caaatagcta 1621 gcttagaagg gattcaatat tgtgataatt taagaaagct tgaattaatg ggaacttatt 1681 taaatgatat tttcttaata aagaatatta agaaactaga gtatttagat ttaagtgata 1741 ataatataaa agatattagt tttatatgta atataaagac tttaaagtat ttaaatttaa 1801 gtggaaatcc aataaaaaat atagattata ttaatgatat aagaagtttg gagcgtatta 1861 atttagaaag aacagattgt gaagttccta atttaagcaa tccagataaa ataatatcat 1921 ttggtttgcc acaaaattgt tttgatttag aatttttaaa tagatataag aatttaaaag 1981 agataacttt accaagttgc ttaaaaacat tagaagttat aaaagagttt aaaaacttgc 2041 ataatgtaga aagtttatct ataaataata gcaaagtaag tgatttaact ccattgtcta 2101 atttaaaaag attaaagaaa ttggattcat ttgccaataa tttggatgat atttctccaa 2161 tttataattt aaaagaatta attagtatta atgtgggtat aaataaaatc tcagatattt 2221 catgtataga atcattaata aatttagagt attttatagc agaacaaaat ctaattaaag 2281 atatagttcc attaaaaaat ctttttcaat taaaagaatt aaatttaagt gggtgccgag 2341 taagtgatat ttcgccatta gaaaagttaa aaaaattaga aattttaaat ttagaagata 2401 atttattaac taatataaat ggaatcgaaa aattagataa attaaaagaa attaatttag 2461 aatataatga aattaatgat atagaaatgt taagaaaact tcaagaaaaa agaaatgatt 2521 tagaagtaat atattaaact tataatatga gctagtgttt ctaattaaag aaacattagc 2581 tttatttatg tttttaaata aatttgattc aactttttat tgtctaaatt taaaaatttt 2641 cattacatta ctttcaatta aaaaatgtaa tatagacatt ataatatgtt ttaaatattc 2701 atgtttaaaa atatgcaata agaataaaaa tcaagttttt catttataga atagcaacta 2761 tgaaactagg gtataaataa ggtgatatac aaaagtacat gctaaggagg gaaaagctta 2821 tgaatatagt tccgtataat gaatatttat tagttatgcc aaatggtgat actaaggggt 2881 tcgatgattt agagttagca aaagcttata taaacatata ttatgaaaga gttatagacc 2941 ataaaattga taaagatgat tataatgatg caacagaaat tggagcagaa gaaccaagaa 3001 gaaatatatg tactcaatta ggagtagctg aaggacgatg tgaagtttat agtatagata 3061 atttcataga agttataaga aataatttgg tttttgatga tgaaagagag gaaataatat 3121 caaaattatt agcaaaggaa ataagcttta atgtttatga ttataattta gatactatat 3181 tagttgatat tgaaagtata gatatgatgg aaccctatgg agatgcagat taatgataaa 3241 aatatcaaaa atttatgtat tattatgttt aataaataaa tgaaataaaa atcattatga 3301 taatataaca tataaaatga ttaaatatta tcaataaaat gactgtttta ttaactaatt 3361 aaaaaatata tattaaaaag tattccttaa tatataagtt ttgtaaaaat aatcttaggt 3421 tgttgacttt gatattttat aagagtaaac tttaaaaaaa gcaaaagtta atggtgtgca 3481 accgttatat gtaagggttt gttagaacct agtgatattt tatataagcg gagattaacc 3541 actttttatg atttgtatca ttaagagtgg tttttgtttt aaataaattt tacggaggta 3601 ttattttatg aggaaatatg tattatccgt tttagtaaag aattcatctg gtgtattaag 3661 tagggtttca gggttatttt caagacgagg atataatatt gatagcataa cagcaggaag 3721 aacagaagat cctttagtat ctagaatgac gattacttta agcggagatg atgatgtttt 3781 agaacaagtt aagaagcaat taaataaact tgaagatgtt ataagagtaa taaatattac 3841 ttctgatgat tctgtttata gagaattagt acttataaaa gttaaagcta gcggagatga 3901 aagagcagca attaatgaaa cagcaaagat atttagatgc aaagtagtgg atgtttcacc 3961 aaacacctta actatagaac tgacaggtga tgagaataaa atatcagcat taataaaact 4021 catggaggag tatgggatag aagagatggt tagaacaggt ataactgctc ttcaaagggg 4081 aatttcaaca attaaaaatt caattgatga atgttaaaat atttgcttga aattaaaaaa 4141 ataggatagg taaagaaata acattaagga ttaggtatta aaaatagggc aagctatatt 4201 taattaattt attaaaaatt tgattctata gtaaatgatg gggcacaaga taaactgagt 4261 taaaaacata tttttaggag gatgataaaa atggggatga caatgactca aaaaatatta 4321 gcggcacatg caggattaga aagtgtaaaa gcaggtcaat taatcgaagt aaatcttgat 4381 ttagttttag gaaatgatat tacaacacca gtggctataa atgaatttaa aaaatttggt 4441 gttgataaag tctttaataa aagtcaaatt gcaattgtgc cagatcactt tactccgaat 4501 aaagatataa aagccgctga acaagtaaag tatgttagag aattttctaa taagatgggg 4561 atagaaaatt tctttgaagt aggagaaatg ggaatagagc attgtttact tcctgaaaaa 4621 ggactagttg ttgcagggga tgtggttatt ggagctgatt ctcatacttg cacatatgga 4681 gcacttgggg cattttctac aggaataggt tcaactgata tggcagcagg aatggctact 4741 ggacaaactt ggttcaaagt tccgtcagct ataaaattta ttcttaaaaa taagccagct 4801 aaatgggtaa gtggaaaaga tattatttta cacataattg gaatgatagg tgttgatgga 4861 gctttatata aatcaatgga gtttgttgga gatggattaa attatctttc catggatgac 4921 agatttacaa tggccaatat ggcaattgaa gcaggtggaa aaaatggaat attcccagta 4981 gatgataaga cagtcgagta tttaaaagaa catactaaga aagagtggga agtttataaa 5041 gctgatgagg atgcagaata tgatgaagtt atagagatag aattaaatac tttaagacca 5101 acagtttcat ttcctcattt acctgataat acaagaacta ttgataatgt aggagatata 5161 gatattgatc aagtagttat tggttcttgt acaaatggaa gaatttcaga tttgagaata 5221 gcaagagata ttttaaaagg taaaaaggtt aaaaaaggaa ttagatgcat agttatccca 5281 ggaactcaaa atatttattt gcaagcatta gaagaaggca ttattaaaga tttaattgaa 5341 gcaggagtag ttgtttcaac gccaacttgt ggtccatgct tgggtggtca tatgggaata 5401 ttagcaaaag gagaaagatg tgtttcaaca acaaatagaa attttgtggg tagaatgggt 5461 catgttgaat cagaagtata tcttgctagt ccagcagtag cagcagcatc ggctttaaca 5521 ggaaaaataa ctgatccaga gttagtgtaa agggggattt ttatatgaat gtaaaaggta 5581 gagtatttaa atatggtgat aatgttgata ctgatgtaat aattccagct aggtatttaa 5641 acacatctaa tcataaagaa cttgcatcac attgtatgga agatatagat aaagaatttg 5701 ttaataatgt aaaagatgga gatataatag ttgctaataa aaattttggt tgtggctctt 5761 caagagaaca tgcacctata gcaattaaag cagcgggaat tagctgtgtt atagcatcaa 5821 catttgcaag aatcttttat aggaattcaa taaatatagg tttaccaata ttagaatgtg 5881 atgaagcagt aaaaaatatt aatcatggag atgaacttga agttgatttc tcgacaggga 5941 taattaagaa tctaagtaaa aatgaacaat atcaaggtga agcatttcct gaatttatgc 6001 aaaaaattat agataacgat gggctaatag ggtatataag aaacaaataa ttttaatgag 6061 taataaggaa taaataaaaa attaaggcaa taagtaaaat tgataattga tacattttat 6121 agggatgaaa taaataatat acaacttaaa gaaattttga aatagttata cttttaattg 6181 tttattataa attatcaatt aaaaaagaag ggggactatt tatgaaatat aatgtggctg 6241 taataccagg ggatggtata ggtcctgata tagtaacaga agctgtaaaa gtattgaatg 6301 tagtaggaga aaagtttgga cataaatttg aatatgaata tgtaatggct ggagggtgtt 6361 ctattgataa aaatggagaa gctcttccaa aggaaactct ggatatatgt aaagcaagtg 6421 atgctgtttt gttaggtgcc gtggggggac caagatggga tgatcctgat tcaaagatta 6481 gacctgaaca agcattattg ggattaagaa gtggaatgaa tctttattgt aatttaagac 6541 cagcagtatt atatgaacct cttaagaatg catcaccact taaagatgaa atggttaaaa 6601 atggaataga tattgctatt gtaagagaac taacaggcgg tatttatttt ggtgaaagag 6661 gaagagatga aatagatgga atagaatcgg cttatgatac agaaagatat agcactgttg 6721 aaataaagag gatagttaaa attggattta aaacagcaat gaagagaaat aaaaaattaa 6781 catgtgttga taaggcaaat atacttgaaa cttctagact ttggagaaaa gtaatcgggg 6841 aaatctcaaa agattatcca gaagttaatg ttaattattt atatatagat aatgcatcaa 6901 tgcaacttgt aaaagatcca actcaatttg atgtaattgt aacttctaat atgtttgggg 6961 atattttgtc tgatgaggct agtatgatta caggatctat tggaatgtta ccatcagcat 7021 cattaggtga ggggacttta ggaatgtatg aaccaattca tggtagtgca cctgatatag 7081 caggtaaggg aattgcaaat ccattagcaa caatattatc tgctgctatg atgcttagat 7141 atagttttga tttagaaagt gaagcaaaac taattgaagg cgcagtgcta tcagttttag 7201 aagatggtta tagaactgga gatataatga gtaaaggcaa aattaaggtt ggaactaatg 7261 aaatgggaga tttagtttgt aagaaaataa ataaggggga atagggagtt atgaaaagtg 7321 atgctataaa aaagggtcct ggaaaagcag ctcaaagatc acttcttaaa gccttagggt 7381 taacaaatga agaaatttca agacctatta taggaatagt ttcatcacaa aatgagatta 7441 ttccaggtca tatgaatctt gataagataa ctgaagctgt tagaaaagga attttaatgt 7501 ctggtggtac gccacttgct atacctacaa ttggggtgtg tgatggcata gcaatgggac 7561 aggaaggaat gaagtattct ttagttacaa gagagcttat agcagattct attgagtgta 7621 tggctaaagc ccatgctttt gatgcattag ttttaattcc aaattgtgat aaaatcgtgc 7681 caggaatggt tatgggtgct ttaagagtta atgttccatc agttgttata agtggggggc 7741 caatgcttgc aggaaaatat aaaggaaaag atatttcttt aactacaatg tttgaagctg 7801 ttggatcgta tgaaaatgga acaatggatg aaaaggaatt atgtgatttg gaagagtgtg 7861 catgtccgac atgtggctca tgttcaggaa tgtttacagc taattctatg aattgtttat 7921 gtgaagtatt aggtatagct ttacctggaa atggaactat accagcagtt ttttctgaaa 7981 gaataagact tgcaaaaaga gcaggtatgg ctgttatgga tatgttaaaa aatgatatta 8041 agccaagaga cattataaat gaaaaaagta ttatgaatgc acttaaagct gatatggcac 8101 ttggatgttc aactaatagt gttcttcata taacagcaat agcaaatgaa gcaaaggtta 8161 atatgaattt agatataata aatgatttat catcaaagac accagatctt tgtaagttag 8221 ctccggcttc aaatgttcat attgaaaatt tatatgcagc aggtggaatt actgcaatga 8281 tgaatgaact ttctaagaaa gacattctag atttagactg tattactgtt acaggaaaaa 8341 cacaagggga aaatataaaa ggagtaacag ttaaggacta tgaggtcatt agaccaatag 8401 ataatccgta tagcaaaaat ggaggaatag caatacttag aggaaactta gctccagatg 8461 gtgcagttgt aaaaagagca gcagttttac ctgagatgtt agttcatgaa ggaccagcta 8521 tagtatttaa ttcggaagag gaagcaaatg aagctatttt taataaaaaa ataaatccag 8581 gtgatgtaat tgtgataagg tatgagggac ctaaaggggg acctggaatg agagagatgc 8641 ttcaagctac agcagcaatt gcagggatgg gacttgatga ttctgttgca cttataactg 8701 atggaagatt tagtggagct actagaggcg catcaatagg tcatgtttct ccagaagctg 8761 catcaggtgg aatgattgga ttaatagaag atggggatat tatttcaata gatataaata 8821 atgcaaaatt agaagttaaa ttaagttacg aagaaattca aagaagaaaa cttaaattta 8881 aaccaataga accaaaagta aaagaggggt acttagctag atatgcaaag cttgtaagct 8941 ctgcaagtga aggtgcaata ttaaagtaat gttctatgtt ttaacaaagc atatttttaa 9001 aacatagtta aattaatacg caaatagcaa taagtaaagc aaaggggtga ataaaatgtt 9061 attaacgggg gctgaaatat tgataaagtc tcttgttgat gagggtatag acacagtttt 9121 tggataccca ggaggggctg ttttaaatat atatgatgaa ttatataaat ataaagagaa 9181 aattcgtcat gttttaactt gtcatgaaca agcagctgca catgcagcag atggatatgc 9241 aagggcaact ggtaaagttg gagtatgtat agcaacatca ggaccaggag ctacaaactt 9301 agttacggga atagcaacag cttatatgga ttcaattcct atggtagcta tcacaggaaa 9361 tgtagctaaa ccacttcttg gtaaagatag ttttcaagaa gtagatataa ctggaattac 9421 aatgcctatt acaaagcaca actatattgt aaaaaatata gaagatcttc aagaggtaat 9481 aagagaagca ttctatatag cagaagaagg tagaaaaggt cctgttttaa tagatatacc 9541 aaaagatata acatctaata aaacagaata taaaaaatta attcctaaaa aaataactag 9601 ggaaatagat gagataaaag aagattcatt taatgaggct ataaattata taaataattg 9661 taaaaagcca tttatatatg ctgggggcgg aattgtttct tctgaggcaa cagaagagct 9721 aataaagttt tcagaaaaaa taggagcacc tgtatctact tctttaatgt gtacttcaga 9781 attcccattt gatcataatt tatatacagg aatgattgga atgcatggga caaaagcatc 9841 aaatataggt gcgactcagt gtgatttgtt aatagtatta ggagcaagat ttagtgacag 9901 agttataagt gatcaaaatc atattaaaaa tgcaaaaata attcatatag atatagatcc 9961 agcagagata aataaaaata taaaagtaaa ttcatcaata attggagatt tgaaatatgt 10021 gttaaataaa ttaataccgt tagtagaaaa aaaggaaagt aaagattgga ttaattttat 10081 agattctctt aaaggaaaaa aacacataga tggaattaat agcggagaat taacaccgaa 10141 gtttttattt gataatctaa ataaactaaa tgatggtagt tttataatta caactgaagt 10201 tggacaacat caaatgtggg cttctcagta ttttaattat acgaatagaa gaagtttctt 10261 aagttctggt ggacttggaa ctatggggta tggctttgga gctgctatag gagctcaaat 10321 aggtaagcct gataaaaaag tatttaatat tgctggagat ggaagctttg gtatgaattg 10381 caatgagatg gctacagcag ttaaaaataa attaccatta gtagttatag ttatgaataa 10441 taatgcacta ggaatggtaa gacaatggca aacattattt tatgaaaaaa gatattcaga 10501 gacaacttta gataggcaaa cagattatgt taagcttgca gaagcttttg gtgctaaggg 10561 atttagggtt gaaaaaagag aaaatcttga agaggtttta aagaaagcaa ttgcctcaaa 10621 agaacctgtt ttaatagatt atgtaataag caatgataaa aaagtttttc ctatggttgc 10681 acctggtgca cccattaatc aacttataag tgaagaagat ataaattaaa ataattaggg 10741 ggacattaaa atgacaaaaa tgtattatga agaagacaca gatttaaatt tattaaaggg 10801 aaagaccatt gcagtaatag gctatggtag tcaaggacat gctcatgcat taaatgctaa 10861 agaatcagga ggtaatgtaa ttataggttt atatgaaggt agtaaatcat gggctaaagc 10921 agaagcacaa ggatttgaag tgtttagcac agctgaggca gcaaaaaaag ctgatataat 10981 catgattctt ataaatgatg aattgcaagc agcaatgtat aaaaaagata ttgcaccaaa 11041 tcttgaagca ggaaatatgt taatgtttgc tcatggtttt aatattcatt tcgatcaaat 11101 aacagcacct aatgatgttg atgtaacaat gattgctcca aaaggacctg gacatacagt 11161 aagaagtgaa tatcaattag gtaaaggagt tccttgtctt gtagcagtgc atcaagatgc 11221 aactggtagg gctttagaaa ctgcacttgc atatgcaaat gcaattggtg gagcaagagc 11281 tggtgtgctt gaaacaacat ttagaacaga aacagaaact gatttatttg gagaacaagc 11341 agttctttgt ggtggtgttt gtgctcttat gcaagcaggg tttgaaacat tagtagaggc 11401 tggatacgat gaaagaaatg cttactttga atgtatccat gaaatgaaat taatagtaga 11461 tcttatttat caatcaggtt ttgctggaat gagatattca atttcaaata cagctgaata 11521 tggtgattat attacaggat ctaagataat tacggaagaa actaagaaga ctatgaagaa 11581 agtacttaag gatattcaag atggaacttt tgcaaaagat ttcttattag atatgtctga 11641 agctggagga caagcccact ttaaagcaat gagaaaattg gcagcagaac atcaatcaga 11701 agcagttggt agtgaaatac gtaaacttta ttgttggaat aatgaagaca aactaataaa 11761 taactaataa attatattaa gatgtaatat gattagaaga atatccaatt aaaaagtggt 11821 aaagaattaa gtggaatgat gagttttatg gctacttgta aagtagatta gtattattaa 11881 aatagatatg tgaaaatata tatttaatat ataagtttta taaattttca tcacaatttt 11941 atgcacagtt tttgtagata acaattttat ttattaaaaa agtgtggata actttaaaaa 12001 atgttagtgt tttagtataa agctcactga actgagaaat ttgctttaag aatactaaaa 12061 taaagattag tctaattaat gcatgttcca aatgagatat tgtgacaagc aattaattca 12121 acaaaccttt attaagaatt ctaaaaagca aatttcaatg ccagattgtc tttatacaaa 12181 aatactaaca gttaaataaa tataatataa aaaaggctat gttttaaaac agtgttgata 12241 tatgcataag caaagtgggc agagtaattg aacttaagaa cactaaaatg ggactatact 12301 tattaagggt tctaaaagtc catttacaat gccacttcac ctattacata tatcaacact 12361 ctgctaaaac atagcctaaa aaaataatca aaggtttaac taagataaag tttaagtata 12421 tttttataac agtttcttca tcatgattga attgactgtt ataaagtgat gggcattagc 12481 agcttttgcg tttttataat atcattatat gaaacttatt ttatgcaagc gcttttactt 12541 atcatataaa aatattgact actttatgtt ataatagtta ctaataacat ataagaaaat 12601 tttgaggaat ttatatatga attacgttta tattttagaa tgttcagata atactttata 12661 tactggatgg acaaatgatt taggtaaaag aataaaaatg cattctttag gaaaaggggc 12721 aaaatataca cggggaagaa ctcctgttaa acttgtatat tatgaaatat ttgaagataa 12781 aaatgaggct atgagaagag agtatagaat aaaaagatta ataaggtcac aaaaagaagc 12841 attaataaaa acttttgatt gtgctttatt atagtgtttg tatatttaaa atgaagtcag 12901 agaatttgga gggtgttatg aaggttacta taaaagaggt cgctaaagaa gcaaatgttt 12961 caacttcaac tgtatctaga gtattatcag atagtagtca gattagtgaa gaaactaaaa 13021 gtaaagtaag agaagctgtt aaaaaattaa agtataaacc taacgcaata gctagaagtt 13081 tagcaaataa taaaacaaga ataataggtg taatacttcc taatgaagca caagacttat 13141 taacaaatcc attcttcatt caagcaatga agggtatgag tgtatatgcg caaagcaaga 13201 attactatat tacttatgcg tttagtaagg atgaagcaca tgaagcacac catgtaaatg 13261 attttataaa tagtaattta gttgatggaa tttgtttgct aagagccaaa tctgatgatg 13321 ataatataag atatttaaaa gaaacaggtt tcccttttgt tgttatagga agaccagaag 13381 aaacagatgg aattttatgg gtagacaatg acaattttaa agcaacatat gatttggtta 13441 atgatttagt taaacgagga aagaaaaaaa tagctttttt aggggctaga gaagaatgga 13501 atttaactaa agatagaata aatggattta aagtatcatg ccaaatgaat ggaattaata 13561 taaaagagca agatattata atcaaagaag aatttactga acaagaagga attgaagcta 13621 ctaatgaatt attaaagtta ggaattcctg atgctattgt agcagaggat gatatgttag 13681 catttggttc attgaaggta tttaaggaaa aaaatttaaa agatatttct ataataggtt 13741 ttaataatac acagttagct gagtttcaaa atccaccatt agcatctgtt gatataaatg 13801 catatgaatt aggatattat gcagctaaga tattaataga ttcattagag aataataata 13861 atatggatca ttatataatt gatactaact tagtagttag agattcaata aaataatatg 13921 ttttattgaa tcatatatgt tttttttgca accgattgcg gagaaatact ttgtaattat 13981 gagaaaaaat atgaaaataa aagaaataag cataattttt atctaagaaa gaaaaaaaat 14041 cttttgtaat cggttcaaaa aattgatata ataaaaatac aaaattaaga taaagactaa 14101 ctttaaatac agatgatgaa tttacattac taagaacttg attaaacaat atatttttag 14161 tatataaaat taatcattta aattttatat tttatgcaag cgattgcgaa aggaatgtat 14221 ttgttaatga aaaaaatttg gtggaaagaa gcaataggtt atcaaattta tcctagaagt 14281 tttaaagatt ctaatgggga tggaattggt gatttaagag gaataatatc taaattagat 14341 tatttaaaag aattaggaat agatgtaatt tggatatgtc caatgtataa atctcctaac 14401 gatgataatg gatatgatat aagtgattat caagatataa tggaagattt tggggagatg 14461 gctgactttg atgaattact aacaaaagtt cataaaagag gtatgaaatt aattattgac 14521 ttagttatca atcatactag tgatgaacat aagtggtttg tagaatctaa gtcatctaaa 14581 gatagtccta aaagagattg gtatgtttgg aaagaaggca aagatggttc tgaacctaat 14641 aattgggaaa gcatatttaa aggttctgca tgggaatatg atgaaaatac agaagaatat 14701 ttcttacatc tattttcaaa aagacaacct gatttaaatt gggaaaatcc tgaagttaga 14761 aatgaactat ataaaatggt aaattggtgg ttagacaaag gtatcgatgg attcagagtt 14821 gatgctataa gtcatattaa aaaagatcaa acttttgaag atattaaaag taaaagtaat 14881 gaaagatatg tatcttcatt tgagaaacat atgaattttc caggtataca taggttttta 14941 gcggaacttg cagataatac ttttgaaaat tatgatatta tgactgttgg tgaagctaat 15001 ggagttgact ctgaagaagc agaactttgg gttggcgaag aagatggaaa gtttaatatg 15061 gtattccaat ttgaacatct taatttatgg gattatgatt cagaaaataa gttattagtt 15121 gtaggcttaa agaaagcttt aacaaaatgg caaaataatt taaatggtgt tggctggaat 15181 gcattattta tagaaaatca tgatattcca agagttattt caacttgggg aaatgatgaa 15241 aattacagaa gagaatgtgc taaagcatta ggtttaatgt atttcatgca acaaggaact 15301 ccttttattt atcaagggca agaacttggt atgaccaatg ttaaatttga aaatataaat 15361 aaatatgatg atataaaatc aataaatata tttaatgaaa gagtagaatg cggagtttct 15421 aaagaagaag cacttaaaga aatatgggca atatcaagag ataattctcg tactccaatg 15481 caatggaatg atagtgaaaa tgctggattc tcaaataata agccttggat agatgttaac 15541 tcaaattata aagaaataaa tgttgaatct gaactaaaag atcctaattc agtattgaat 15601 ttctataaga aaatgataga cgttaaaaaa aatagtgaaa ctttaagtta tggcgaatat 15661 aaacttattt tagatgaaga tgaaaatata tattcatata tgagaatttt gggtgataag 15721 aaatatatga ttatatgcaa tctatcagat aatgaaaatt tatataaata tgaaaaagaa 15781 acattaacat ttgaaagctt aattttgtca aattatgagg taaataagca tgacaaaatt 15841 aatagtataa atttaaaacc atgggaatgt agattatata aattaatgta gaattaattt 15901 tatttatggt aaagggtatt gagaaaaata taataaggat agggtggaga atatgaaagc 15961 gaaaaaagaa aagttatttt catttgaatt ttggcaaaag tttggtaagg cacttatggt 16021 ggttgttgca gtaatgccag cagcgggatt aatgatttgt cttggaaaat taataggaat 16081 gtctggagat ttagctttaa tgcaaaccat tgcaagagtt gttgaagact taggatgggg 16141 gattattggt aatttacaca ttctatttgc agttgcaata ggtggatctt gggcgaagga 16201 acgtgcaggt ggagcatttg cagcactgat agcatttata cttactaatc gtgttacagg 16261 agctatattt ggagtgagtt cagcaatgtt agcagataaa actgcaacag taacatcact 16321 ttttggaaaa caattaatag ttggagatta ttttacatct atacttggag caccagcttt 16381 aaatatggga gtttttattg gaattatttc aggtttttta ggggcctcat tatataataa 16441 gtattacaac tttaataaat tacctaatgc attatcattc tttaatggta aacgttttgt 16501 tccttttgta gtaattgcag gatcagtagt aatggctatt gtactttcaa tcatatggcc 16561 atttgctcaa tcaggattaa acgcgtttgg tgtatggctt gcagaatcta aagacacagc 16621 accaatatta tcaccattta tatatggctg tttagaacgt ttactattac cgtttggatt 16681 acatcatatg cttacaatac cagtaaatta tactgaatta ggtggagtat atactatttt 16741 aactggagct aatgctggac atgttatagc aggtcaagat ccattatggt ttgcatggat 16801 atcagattta ataaatttaa agggtgcagg agatatgtct gcatataata acttattaac 16861 aacagttaca ccagcaagat ttaagtatgg tcaagtagtt ctttcaagtg cttcattaat 16921 aggggtagca cttgcaatgt ataagaatgt tgatgaagat aagaaacata aatataaatc 16981 aatgttttta tcagcaggtc ttgcagtgtt tttaacaggt gttacagaac caatagaatt 17041 tatgtttatg tttgtatcac caattcttta tggagtatat gcagttatca caggtatagg 17101 atttgcttta gcagatatta ttagtttaag aattcaagct ttcggatttg ttgaattatt 17161 aactcgtgta cctatgtttg taaaagcagg attatcaatg gatttagtgc attttgtaat 17221 tagtgcagtt gccttcttct tcttaaatta ctgcacattt aatttcttaa taaagaaatt 17281 taagattgcc actcctggta gaagaggaaa ctatatagat tcagaagaag atgaatcttc 17341 acaaaacgca tcaaatacaa atacaacagg tgatgaatta gcagtaaaaa taatttcatt 17401 attaggtgaa agagaaaata ttatagatgt tgatgcttgt atgactcgtt taagagtaac 17461 cgtaaaagat aaagttttag ttgctgatga aaaagattgg aagaaaaatg gagctcttgg 17521 tttagtagta aaagataaag gaattcaagc tatatatgga cctaaagctg atgttttaaa 17581 atcaaatatt caagatatat tgggagtgta gtaaagtgaa attattaact ttaaactgtc 17641 attcttggca agaagagaat caaatagata aaataaagta tttagctaag ataataagtg 17701 aaaagaatta tgatgcaata gcacttcaag aaataagtca atcaattgag gcaaaagtta 17761 ttaataataa tttaaaagtt gataattttg cagtgttatt aaaggcagaa ttagataaat 17821 ataatactaa ctataatttt ttctgggatt tctctcatat aggttatgga aaatatgaag 17881 aaggtttagc tgtatttact aaacataata tagttaatga aaagtcattt tttataagca 17941 aaggaacaga tagagagtat tggaaaacta gaaaaattgt gcaagttaca tttgaatata 18001 ataatgaaaa tatagatctt tattcttgtc atctaggttg gtgggaagat gaagaagaac 18061 catttaaata tcaagtaaaa agactattag aagaaaacac ttctaataat ataacatttt 18121 ttatgggtga ttttaataat aatgcattcg taagaaatga aggatatgat tatttagtta 18181 ataaaggatt agttgataca tttaacatat caaaagaagc tgataatgga attacagtta 18241 aaggaaatat agatggctgg gatgaaaata aagataagct aagattggat ttaattttaa 18301 gtaataaaaa attagatgta ataacttcta aagtaatctt taatggaaca aataaagatg 18361 taatatctga tcactacggt gttgaaatta gcctaaactt ataaattaaa ataaatcaaa 18421 aataagacgg atgattttat ccgtcttatt ttttttctat tttttgcatt atatcgtata 18481 gctttgatac acaatcactt aatgcatata aatcatcatc atctaaaatt tcaattttac 18541 ttgctaattt agcttttgca gcatttctga atttttcaaa tatatctaat gcctttgcag 18601 ttaattcaac tctaagtatt cgtctatctt tagaatctgg atatctatta actagaccgt 18661 attctataag cttatctatt atgggtgtca tattagattt agatatacct aaattactag 18721 ctatttgaga tattggtgaa gaacttgatt tatgaagata cagaattact tttgtatgag 18781 atggtggcat aggaaattca ttcatataat cctcaacttc ttttggtggt ttaggaaaat 18841 tctttataaa ttcattttca ctaaatacat tatttttaac taaaaataaa aaagttaata 18901 aagaatcgga aattttatct aaatcttgtt tatgcat //