LOCUS NC_010465:3 18746 bp DNA linear BCT 06-OCT-2011 DEFINITION Yersinia pseudotuberculosis YPIII, complete genome. ACCESSION NC_010465 SOURCE Yersinia pseudotuberculosis YPIII, complete genome. COMMENT locus start: 522649; locus end: 541394 FEATURES Location/Qualifiers source 1..18746 /organism="Yersinia pseudotuberculosis YPIII, complete genome." gene complement(0..4469) /gene="" /locus_tag="" /db_xref="522649..527118" CDS complement(0..4469) /gene="" /product="virulence plasmid 65kDa B protein" /translation="MENSKQQVAVAPLSLPKGGGAITGMGDSLGPIGPSGMATLTLPL PISAGRGYAPSLTLSYSSGSGNGPFGLGWQLGTMAIRRRTNAQVPRYDEYDEFLAPNG EVMVVAADPQGNIERTEQSLNGEQFSVIRYLPRIEGNFHRIEYWRPRTNNSQAPFWLV HSSDGQKHGLGYSASARIADPLHPEHIAEWLLEESVSLSGEHICYQYQAEDEQDIDES EKQNHPAASAQRYLSTVVYGNREVAHELYCLTQRPAPTSWLFSLIFDHGEYSNIAEQV PVIIKGKSWNFRQDAFSRFSCGFEVRTRRLCQQVLMYHNLSALKGDEPDAQATLVSRL RLHYQHDAYATQLVGCQQLAHEPDGTKRSLPPLEFDYQDFSTRDALGWQPLTDWAEFN YQYQMVDLNGEGIPGMLYQDSGHWIYRPPVRQPGTADGITFGAAQRLPSLPAMRENAM LMDINGDGKLDWVISQPGLAGYFSRDPDLSRDPDLSWTQFIPLSTLPAEYFHPQAQLV DLAGSGLSDLALVGPKSVRVYTNLCDSFAAATQVAQDDDITLPLPGVHFTELVAFSDV MGSGQQHLVRIRHNSVTCWPNLGHGRFGHPLSLPGFNQPIEQFNPLAIYLADIDGSGT IDLIYATTSQLLIYRNQSGNRFAEPVAIALPTGIRFDNSCQLSLADIQGLGVASIMLS VPHPTTQHWRYDFVASKPYLLCTTNNNMGAESQLFYRSSAQFWLDEKAQAAKQGRSLA CQLPFPIHLLAQTTQLDEITGNSLSQTARYFHGFYDGVQREFCGFGRVDTLDTDTSAQ GSAAERTAPTKSSNWFHTGRADNETLWQSEYWQGDDQDYPLLPTRLTKFINDTQGDDV LSELDDNQTFWLHRALKGSLLRSELYGLDGSELATQPYSVNSARYQVRQIQSSTDEIT SPVALPMMLEQLNYHYERIVQDPQCNQQIVLRCDEFGHPLHSATIYYPRRDKASIPPY SWLAEGHWDSHFDEQQQQLRITESQQSYHHEISDKFYVLGLPAGQRSDVLTYPDNFVP TAGIHWEELQQPEGLLGTKAERTFAGQQQVFYASDTIPGLVAYSQQAEFDDQTLAALD ELLPTNEREQQLIEAGYQRAPRLFSRPGETDIWAAQRGFTDYGDASRFYRPISQRSSP LVGKTALEWDKNSCAITQMILADGSTTQAEYDYRFITPYHLTDINDNSRHIELDALGR VTSSRFWGTELDSQTGEVSTTGFPLIAEPPFTVPNSVDAAISMENTQVPVAQFSVYQP QSWMISLQLDDIETLSETNNVTLEYLFQNHILIDNYYLCPLALRRWIRQSNPLITEYV GLTLKNPVRQPPHVLTVVVDNYFSAAEPQQHQQTLAFSDGFGRVLQSAQRVEAGTAYF HTGEGGLEMDQQGHLTQDESDQRWAVSGRTEYDNKGLPIRRYQPYFLDDWRYIADDNA RKEAWADTHIYDPLGREIKVITAKGYLRRAHYFPWFVISEDENDTASEITPNP" gene complement(4526..8119) /gene="" /locus_tag="" /db_xref="527175..530768" CDS complement(4526..8119) /gene="" /product="toxin subunit" /translation="MPTSTVLNKINESRRDALVNYYLAKNVSGDEKIKTAEQLYQYLL LDTKIGHEVKTSSIAEAISSLQIYINRCVDGEENDLHEKNISTHFSSDNFLHGWNSYN KRYARWAGKEKLMYYAADYIDPTLRYNKTELFNTFEQSINNSRLTEKSVKSALQSYLI SYEKLAQIDTIKELYVENIKTHFFLGKTRESPCQYYWRSGEQLSNDSHHLRWSEWKKV NCNINGTEEKFFINLSWHRSSLYIDWINKFSIRTDKDETTEKYHYNRVYKNDDNTWSE LIINMDIGFKLSTSTEVITLPPFFVNQGNQNAKEEVENLFLTNGTSIKKIESRIHGYI KGHIKVLCNDDGISFEIAEKLINGDNGTIGDIKIVENGKNILVINNEKGENKKINLID KFEIKIFPYNELVASTIAFNRIKPEEKIIDELDDKISLLSPNSLPLKEKFQTSVDELL SYNTQKNNVKLDAFNGSYGIYLWELFFHIPLLASMRFLNEQRFDLAKHWLKYLFNSAG YRDGNGNLLKEGDNILYWNSLPLQQDTAWDNNTLIQATDDPDVIAMQDPMQYKLAIFM RTLDLIISQGDQAYRQLERDTLAEAKIHYIQASQLLGPRPNLNRGHQWEDIKLAEESR QLENSHFLPPYNELLLSYWDKLEIRLYNLRHNLNLDGQPLHLPLFATPVDPKALQRQH GAGNGIISSEQMATAQTSLYRFPLLIERAKSAVSSVIQFGNSLQSVLERQDNEAMTLL FQQQQQKVLQHTKDIQNNNIQVLQASLEATDSLKSAAEQRRKHYKELLDNGISSDEQL AINIRIASAALNAESLVPLGLSAVLDTAPNVFGLADGGSRWGAISQAVGWGMQSLALG LETTAGVRDAKANYSRRAQEWTLQKNQADKDIEQLAHQYTSVREQLNMAQKQLNLAEL EQGHADALYQMQSSRFTGKELYNWMAGRLSGLYFQLFDATQPLCLMAKAVLEKEVDKA KTDGLFIRSGWNDLYQGLLAGEDLQLNLQKLENVWLMEEQRALEVERTVSLAQHYQQL SDHKFNLAEIVTGYMAQDKDQKTGNEQDFVELKNSTLITSLSIKGLNLVEDYPETMHL GDIRRIKQISVSLPALLGPYQDVQATLDYAGENTHLAKGCTALAISRGMNDSGQFLLD FNDGKYLPFEGIDISDKGTLVLRFPNATSKQKLLLQSLSDIILHIRYTIRS" gene complement(8160..10661) /gene="" /locus_tag="" /db_xref="530809..533310" CDS complement(8160..10661) /gene="" /product="virulence plasmid 28.1 kDa A protein" /translation="MQDNIDHTASVITDTDNTIHQQAKAEERHRQAVRRATQLRNDPV LSGINKLAFSVAPKILQPEARTDLSLAEGIPERANEYADPASIQSLFSPGRYLCELYH VAKELHEDGNKLHIDQRRPDLQDLVLNNSNMNQEVSSLEILLNVLQTKAPLDELTKDT EAHVNDVSFTLPYDDNLTVINAVLQDKSTSLREIAALLAENNDPWANPITPALVQEQL GLNPASYELIDIKSPLDESYAKRLAHATQLSVEQLQWLNKNAIENSSNKNDPAKLEIL AVISEYRRLHQRYGLSVDPFIAIINAVNTTHTNENKTSFFQQIFSTLDVDAGFNFLDQ GSWEVIIRKALGITAEELLRIAKYCFGKSSISNVKMNSKKFSQLYRMAMIPRTLGVSF SQAEYLWQLYSHPDENIMEKIAQGNALTIIDAIIVLENTLQWMSEQKLDITTLQAMLT KQYSTTATPELFNFLSNIYQTLGKQVYSESLKPNLYRSLANGFHLKANVVAGLVNWLA KNDSEFTLERFWQNISMTFAEEPSLHQLEVHQPLILQCQKLSQYVLIAQWAMLSEQEI ALILLPNGIDNRGRAPSPSITLLKLLSEFKLWQQEAEVSQSELFDIMQQLITGTNEKQ ENLRNAAEKVLRSIAKNIGDIDSDIDRADSTINIRNGSATLFPPEHPMYKALKLEVSN LEKSKIQLEGKKKEEEIKLEQAKDNIQSLINNWDSEIIIRLADAYHWDINIANSMFIL IFGEKINFTFHYENRNDYHYEEHYGYRFEQKPMYSFDKKLTNGFGSILLLKNHIYIAE KLKIHPGTIIKIKNYIFDDKSNELENIANKLRVNL" gene complement(10897..11709) /gene="" /locus_tag="" /db_xref="533546..534358" CDS complement(10897..11709) /gene="" /product="transcriptional regulator, LysR family" /translation="LTNAAVKLFTTPPPMSRSLKILEEELGFKLFTRTTSGLKLTLEG AAFYQEIYPTYVRLTEITKNYKKNKNGIINIATYQLNSDHAGVICDYFIKKGNFNIEL RENIGDISQMDIVISTKEIKGYDFDTELTASCEIKLLYASHLNDLPDRVEYLKKLPFI QSSIFCSSCCFKRFSHNLIQQGYSGNVLRIDDARVRHEIIKKGAGISLSTNYFFDKKK ISHSTEISFISDINFDITYYIYFKSSVINKEFFIQYITNNSLLQWQKAEKKH" gene complement(12024..12935) /gene="" /locus_tag="" /db_xref="534673..535584" CDS complement(12024..12935) /gene="" /product="transcriptional regulator, LysR family" /translation="MERLKQMSVFAKVVECGSFTAAARRLENSVSSISQTVSKLENEL NVKLLNRSTRRIGLTEAGRIYYQGCRRMLQEVQQVHEQLYAFNNTPTGTLRIGCSSTM AQNVLATMTADMLKAYPGLSVNLVAGIPAPDLIADGLDVVIRVGALQNSGLFSRRLGA MPMVVCAAKSYLSQYGTPAKPSDMANFSWLEYNVRPDSNFELIAPEGITTQISPQGRF VTNDSQTMIRWLKAGAGIAYAPLMWVIEEIKRGEVEILFKHYHSDPRPVYALYTEKDK MPLKVQVCIDYLTEYFKRVADVYQDYR" gene 13238..13441 /gene="" /locus_tag="" /db_xref="535887..536090" CDS 13238..13441 /gene="" /product="protein of unknown function DUF1656" /translation="MSLLPVMVIFGLSFPPIFLELLISLALFFVVRRILQPTGIYEFV WHPALFNTALYCCLFYLTSRLFS" gene 13449..14384 /gene="" /locus_tag="" /db_xref="536098..537033" CDS 13449..14384 /gene="" /product="secretion protein HlyD family protein" /translation="VSTFSLKIIRVGITVLVVVLAVIAIFNVWAFYTESPWTRDAKFT ADVVAIAPDVSGLLTEVPVKDNQLVQKGQILFVIDQPRYQQALAEAEADVAYYQTLAA EKQRESSRRHRLGIQALSQEEIDQASNVLQTVQHQLAKAIAVRDLARLDLERTTVRAP AEGWVTNLNVHAGEFINRGATAVALVKKDTFYILAYLEETKLEGVKPGYRAEITPLGS NRILHGTVDSISAGVTNSSSSADSKGLATIDNNLEWVRLAQRVPVKIHLDSEDQQYLY PAGTTATVVITGPNDRDPHQVSPMTKLMHRLREFG" gene 14386..16341 /gene="" /locus_tag="" /db_xref="537035..538990" CDS 14386..16341 /gene="" /product="Fusaric acid resistance protein conserved region" /translation="MTHPSFIRLRFAFKLSFAIVAALFLGFHLQLETPRWSVLTAAIV SAGPAFAAGGEPFSGAIRHRGWLRIIGTFIGCIGGLVIIVLTIRAPVLTLMLCCLWAG ICTWISSLVRVENSYAFGLAGYTALIIIVTTGETPLLTPQFAVERCSEIVLGIVCAVM ADLLFSPRSIKQDIDRLVDKVLVDQYRLLQLCIQPAEKSEIDRAWNELVKNTTSLNGM RSYLMMESSRWQRCNRRLQVLHTESLALITQACETYLVMSNHPEVISAELKTMLSEPA QTPAEIHQQMKKLRQFIAASHSEAIPHTISSWVGAATRYLLLSKGIQTNSSINQVEED ILAGDAPVKPISAEGHHAMINGLRTGIATAIGGLFWLWTGWTSGAGCMVMIAVVTSLA MRTPNPRRMALDFLVGVIIALPIGALYFMFIIPSTQQSMLLLCISLGVLAFIIGIEVQ KRRLGSLGTLASTINIIVLSNPMIFNVRQFLDSALGQIVGCFVSLIVLLLIRDNAKDR TGRTLLNRFVYSAVSALTTNKTKRGENHLPALYQQLNQLLMMFPADIDKYRLALTLII AHQRLNRTEIPVNAELSAFHKQIRSTAERVITVNNDQKRRYYFARLLQELDQYQQKLV DYQAADAVIRPVKRLTEMLRKYQSALI" gene 16608..18077 /gene="" /locus_tag="" /db_xref="539257..540726" CDS 16608..18077 /gene="" /product="succinic semialdehyde dehydrogenase" /translation="MPAQNPLQHQRQHDGIYHIGYFVGGKWSQAQEQFDVCNPATGEL VARVAKSGKQETEAAIKAASEAFPAWRKTPAKQRAEILQRWYLLIMEHQQSLAELMVS EQGKPLKEALVEVAYAASFIQWFSEQAKRANGEIIPSAKEGARILATREPIGVVAAIT PWNFPLAMLTRKLGPALAAGCTGLIKPANNTPLSAFALLALAEQAGVPAGVLNGVVGD THAISDAIMASSDVRKISFTGSTNVGKTLMRNAAATMKRISMELGGNAPYIVFDDADL EAAVAGAMACKFRNAGQVCVCVNRFYIQDAIYDEFVNRLAAEVKKLKVGNGMDKDVNM GPLINLAGLEKVEEHVKDALEKGGRLLAGGHRHALGGNFFQPTVIADANEQMKVASEE TFGPLAACFRFSTEAEVIQRANNTPFGLAAYFYTQNLQRVFRVSEALESGMIGVNECS VSTELAPFGGVKESGLGREGSVLGLDEFMEVKTLHLGNL" gene 18272..18745 /gene="" /locus_tag="" /db_xref="540921..541394" CDS 18272..18745 /gene="" /product="guanine-specific ribonuclease N1 and T1" /translation="MNKRLMAILGAVLLLIAGAWQGIDGVTVRDIGSSAELERPALSA SAATESLTQHQKVVKYLQTHHRLPDFYLTKKQAREQGWDAQKGNLCDVLPGKAIGGDR FSNRERQLPDAKGRHWREADVNYRCGRRGSDRLLYSNDGLIYLTQDHYKHFIRME" ORIGIN 1 ttagggattc ggcgtgattt ctgacgccgt gtcattttca tcctcgctga taacaaacca 61 cgggaaatag tgtgctcgtc gcaggtaacc tttggcggtg atcactttta tttctcgtcc 121 gagtgggtcg taaatatggg tgtcggccca ggcttctttg cgggcgttgt catccgcgat 181 ataacgccag tcatcgagga aatagggttg atagcggcgg ataggcagac ctttattgtc 241 gtactcggta cggccagaaa ctgcccagcg ttgatcgctc tcgtcttgcg tgagatgacc 301 ttgttgatcc atctccagac cgccctctcc tgtgtggaaa taagcggttc ctgcctccac 361 ccgttgcgcg ctttgcaaca cgcggccaaa gccgtcgctg aaagcgagag tttgttgatg 421 ttgttgtggc tcagcagcag aaaagtagtt atccacgacg acggttaaga catggggggg 481 ttggcgcacg ggatttttca atgtcaggcc gacgtattcg gtgatgagag ggttgctttg 541 tcttatccag cgacgtagcg caagggggca aagataatag ttatcgatca gaatatgatt 601 ctggaataga tattctagag tgacgttatt ggtttcagac aatgtttcaa tgtcatcaag 661 ctgtaacgaa atcatccagc tttgaggttg atagacagag aattgcgcga cgggaacctg 721 ggtattctcc atgctgatag cggcatcaac tgaattgggt acggtaaagg ggggctcagc 781 gattaaaggg aaaccggttg tgctgacctc accggtttgt gagtcaagct cggtgcccca 841 aaaacggctg gaggtgacgc gccccagcgc atccagttca atatgacggg agttatcgtt 901 gatatccgtg aggtgataag gggtgataaa acgataatca tattcagcct gggtggtact 961 gccatcagcc aatatcattt gggtaatggc acagctattt ttatcccatt ctaaggctgt 1021 ttttcctacc aatggtgagc tacgttgact gatggggcgg tagaaacgag atgcatcgcc 1081 atagtcagta aacccacgtt gggcggccca aatatctgtt tctccggggc gagaaaatag 1141 acggggtgct cgttgataac ctgcctcgat aagctgttgt tcacgctcat tcgttggtaa 1201 taattcatcc aacgcggcca aggtttgatc gtcaaattcc gcctgttggc tataggcaac 1261 caggcccgga atggtgtccg aggcgtagaa aacctgctgc tgcccggcaa aggttcgctc 1321 tgctttagta ccgagcaggc cctctggttg ttgtaattct tcccaatgaa tccccgctgt 1381 aggcacgaaa ttgtctggat aggtcagtac atcactgcgc tgcccggccg gcaggcctag 1441 cacatagaat ttatcactga tctcatggtg ataagattgc tggctttcag tgatgcgcaa 1501 ctgctgctgc tgctcgtcaa aatggctgtc ccaatgtcct tcagccagcc aggaatacgg 1561 aggaatactg gctttatcgc ggcgtggata atagattgtc gcactgtgca atgggtgacc 1621 aaattcatcg caacgtagca caatctgttg gttgcattgc gggtcttgca ctatgcgttc 1681 gtagtgatag ttgagttgtt ccagcatcat cggtaatgct accggggagg ttatttcatc 1741 cgtagaggat tgaatttgcc gcacctgata gcgagcactg ttgacgctat agggttgtgt 1801 ggccagttcg ctaccgtcca gaccatagag ttcgctgcgc aacaatgaac ctttcagtgc 1861 ccggtgtaac caaaacgttt gattatcatc gagttcactg agtacgtcgt caccttgggt 1921 atcgttaata aattttgtca gacgggtggg aagtaatggg tagtcttggt catcgccctg 1981 ccagtactca ctttgccata gtgtctcatt gtctgcccgg ccggtatgga accagttact 2041 acttttggtc ggcgcagtgc gttcagcggc gctgccttgt gcggaggtat cggtatccag 2101 cgtatcgaca cggccaaaac cacagaattc acgttgtacg ccatcataaa aaccatggaa 2161 gtagcgggcg gtttgactca ggctgtttcc ggtgatctca tcaagttgtg tggtttgcgc 2221 taatagatgg atcggaaagg gtaactggca ggccagtgat cggccctgtt tggccgcctg 2281 cgctttttca tccagccaga attgggctga actgcggtaa aacaactgac tctctgcgcc 2341 catattattg ttggtggtgc acagtaaata gggtttactg gcgacaaaat catagcgcca 2401 atgttgtgtg gtggggtgcg gcacactcaa catgatgctg gccacgccca gcccctgaat 2461 atctgccagt gacagttggc agctattatc aaagcgaatg cctgttggca atgcgatagc 2521 cactggttcg gcaaagcggt taccactctg gttgcggtaa atcagcagtt ggctggtggt 2581 ggcataaata aggtcaatgg taccggagcc atcaatatcc gccagataga tcgctagcgg 2641 attaaattgc tcaatgggct ggttaaaccc cggtaaagag agggggtgac caaaacggcc 2701 atggccgaga ttgggccagc aggtgacgct attgtggcgt attcgcacca gatgttgttg 2761 gcccgacccc atcacatcgc tgaacgccac cagttcagtg aagtgaactc cgggcagtgg 2821 tagcgtgatg tcatcatctt gtgctacttg ggttgcggca gcaaaactgt cacacagatt 2881 ggtatacacg cggacacttt ttggcccgac taacgccaga tcagataacc cgctgccggc 2941 taaatcgacc agttgcgctt gtggatggaa atactccgct ggcaaggtag ataacgggat 3001 gaattgtgtc cagctaagat caggatcacg gctaaggtca ggatcacggc taaagtagcc 3061 cgctaagccc ggttgactga tcacccaatc cagcttgccg tcaccattga tatccatcaa 3121 catggcattt tcgcgcatcg cgggtaggct cggtaaccgt tgggccgcgc caaaagtgat 3181 gccgtcggcg gtgcctggtt ggcgaaccgg tgggcgataa atccagtgac cgctgtcctg 3241 atacaacatc cccggtatcc cttcaccgtt gagatccacc atttggtact gatagttaaa 3301 ttcagcccaa tcagtaagtg gttgccaacc aagggcgtca cgcgttgaaa aatcctgata 3361 atcaaattct agcggtggca ggctacgttt ggtgccatcg ggttcatggg ctaactgctg 3421 acaacccacc agttgggtgg cataagcatc gtgctgatag tgtaaacgca gacggctaac 3481 cagcgtggct tgagcatcgg gttcatcacc tttaagcgct gacaaattat ggtacatcaa 3541 cacttgctga cacaggcggc gggtacgcac ttcaaagccg caactaaagc gtgagaaggc 3601 gtcctgacgg aaattccaag attttccttt tatgattacc ggcacctgct ccgcaatatt 3661 actgtattcg ccgtgatcga agatcaggct aaataaccag cttgtcggcg caggtcgctg 3721 agtcagacaa tagagttcat gcgccacttc tctattgcca taaaccacgg tgcttagata 3781 gcgttgcgca ctggctgccg gatgattttg tttctcagat tcgtcaatat cctgttcatc 3841 ttctgcctga tactggtagc agatatgctc accgctcaga gacaccgact cttccagtag 3901 ccattcagca atatgctcag ggtgcagtgg atcggcaatt cgggctgagg cggaatatcc 3961 caaaccgtgt ttttggccat ctgaactgtg gactaaccaa aacggtgcct ggctgttatt 4021 tgtccggggt cgccaatact caatgcgatg aaaattgcct tcaatacgtg gtaagtaacg 4081 aattacgctg aattgttccc catttagtga ctgttcagtg cgttcgatat tgccctgcgg 4141 atccgcggca accaccatga cttccccatt gggagccaga aattcatcat actcatcgta 4201 acgtggcact tgggcgttgg ttcggcggcg aatcgccatg gtgccgagtt gccagccaag 4261 gccaaacggg ccgttaccac tgccgctact gtaacttagc gtgagcgagg gggcgtaacc 4321 gcggcctgcg gagatcggca ggggcagcgt cagtgttgcc atgccactgg ggccgatagg 4381 acctaaacta tcgcccatac cggtaatcgc accgccccct ttagggagcg acaagggagc 4441 aacggccact tgctgtttac tgttttccat aaagggctct cctatcaggc cctctgtggg 4501 gcctgttgac tgaggtaacg gcgttatcag gaacggatgg tgtagcgaat atgcaaaatg 4561 atgtcgctca ggctttgcag cagcagtttt tgtttgctag ttgcattagg gaagcgcagc 4621 accaatgtgc ccttgtcgct gatatcaatt ccttcaaacg gcagatattt accgtcgtta 4681 aagtccagta ggaactggcc gctatcgttc attccgcggg agattgccag cgcggtacac 4741 ccttttgcca gatgggtatt ttcacccgca taatcgagag tggcttgaac atcctgatac 4801 ggccctaaca gcgccggtaa actcacgctt atctgcttga tgcggcggat atcacccaaa 4861 tgcatggttt ccggatagtc ctcaaccagg ttcaggccct tgatgctgag ggaggtaatt 4921 aaggtgctat tttttaattc aacaaagtct tgttcattac cggttttttg gtctttatct 4981 tgcgccatat agcccgtaac gatttctgcc agattgaact tatggtcgct tagctgttga 5041 taatgttgtg ccaatgaaac ggtacgctct acttccagcg cccgctgttc ttccatcagc 5101 cacacatttt ccaatttttg cagattgagt tgcaggtctt cacccgccag tagtccttga 5161 tagagatcgt tccaaccgga gcggataaat aagccatcgg ttttcgcttt atcgacctct 5221 ttttccagta ccgcctttgc cattaaacac aggggttgag tggcatcaaa cagttggaaa 5281 tagaggcccg aaaggcgacc tgccatccag ttgtataact ctttgccggt aaaacggctg 5341 ctttgcatct gatacagagc gtcggcatgg ccttgctcta actcagctaa attcagctgt 5401 ttttgcgcca tattgagctg ttcccgcaca ctggtatatt ggtgcgctaa ctgttcaata 5461 tctttatccg cctgattttt ttgcaaggtc cactcttgtg cgcgacggct ataattggct 5521 tttgcatcac gaacacccgc ggtggtttcc aggccgagag ccagactctg cattccccag 5581 ccaaccgcct gtgatatcgc cccccagcga gaacccccgt cagccaagcc aaaaacattg 5641 ggcgcagtat ccaaaacagc actaagcccc aaggggacga gagactcagc attgagggcc 5701 gcagaggcaa tacggatatt aatcgctaat tgctcatcgc tggaaatacc gttatccagc 5761 agctccttat aatgcttacg ccgttgttct gcagcacttt tgagtgaatc tgtcgcttct 5821 aggctggctt gcaagacttg gatattattg ttttgaatat ctttagtgtg ctgcaaaact 5881 ttctgttgct gttgttggaa caataacgtc atggcttcgt tatcctgcct ctccagcacg 5941 ctttgcaggc tgttgccgaa ctgaatcacc gaactgacgg cactttttgc tcgttcaatt 6001 aacagtggaa agcgatacag cgaggtttgc gctgttgcca tttgctcact actaatgatg 6061 ccattaccgg ccccgtgttg acgctgcaat gctttaggat caaccggtgt agcaaagagg 6121 ggtaaatgta atggttgacc atccaagttc aggttatggc gcaggttata taagcgaatt 6181 tccagtttat cccaatagga taataacagt tcattatagg gtggcaggaa atgactattc 6241 tccaattggc gactttcttc tgctaatttg atgtcttccc actgatgacc acgattaagg 6301 tttgggcgtg gccctaataa ttgactggcc tgaatatagt gtattttagc ttcggccagc 6361 gtatcccgtt ctaattgacg ataagcttga tcgccttggc taataatcaa gtctaaggta 6421 cgcataaaga tcgccagctt atattgcatc ggatcttgca tggcaataac atccgggtcg 6481 tcggttgcct gtattagcgt attgttatcc caagcggtat cttgttgcag tggcaggcta 6541 ttccaataaa ggatattatc gccttccttt agcaagttgc cattcccatc acgataaccg 6601 gcactattaa acagatattt taaccagtgc ttcgccagat caaagcgttg ttcatttagg 6661 aaccgcatag acgccagtaa cggaatgtga aagaataact cccataaata aataccgtaa 6721 gacccattga atgcatctaa tttaacgtta tttttttggg tattataact gagtaactca 6781 tcaactgatg tttgaaattt ttcttttaat ggcaggctat tcggtgatag taaagagatt 6841 ttatcgtcta attcatcgat tattttttct tcaggcttta ttctattgaa tgcaatagta 6901 ctggctacca attcattata tggaaatatt ttaatttcaa atttatctat aagatttatt 6961 tttttatttt ctcccttttc attgtttata actaatatat tctttccatt ttcaactatt 7021 ttaatgtcac cgatggtgcc attatctcca ttgataagtt tttccgctat ttcaaacgat 7081 atgccatcgt cattgcacaa tactttaata tgacctttaa tataaccatg aatgcgtgac 7141 tctatttttt ttatgctggt tccattagtt aaaaataaat tttcaacttc ttctttagcg 7201 ttttgattac cttgatttac aaagaaagga ggcaatgtta taacctcggt tgaggtgctc 7261 aacttaaatc ctatatccat attgataatg agttctgacc aagtgttatc atcgtttttg 7321 tatacacgat tgtaatgata tttctctgtg gtttcatctt tatcggtcct aatggagaat 7381 ttattaatcc aatcaatata aagactactt cgatgccaac taagattgat aaagaatttt 7441 tcttctgtac cattgatatt gcaattgact tttttccatt cagaccagcg tagatgatgg 7501 ctatcattag acaattgttc accactacgc caataatatt ggcaaggtga ttcacgggtt 7561 ttaccgagga aaaaatgagt cttaatgttt tctacataca actctttgat agtatctatt 7621 tgagccagtt tttcatagct gattaaatag ctttgcaatg ctgatttgac tgatttttcc 7681 gtcagtctgc tgttgttgat actttgttca aaagtattaa atagctcagt tttattatag 7741 cgcaatgtag ggtcaatata gtctgccgca taatacatta acttctcttt acccgcccag 7801 cgcgcatagc gtttattata actgttccag ccatgcagaa agttatcgct actgaaatgt 7861 gtactgatgt ttttttcatg gagatcattt tcttctccat caacacagcg attaatataa 7921 atttgtaggc tactgatcgc ttcggcaata gatgaggttt ttacttcatg gccaatttta 7981 gtgtctaaca ataaatattg atacagttgt tctgcagttt taattttctc gtcaccgctg 8041 acatttttag caagatagta gttaaccaat gcgtcgcggc gcgattcgtt aattttattt 8101 aatacagtgc tagtaggcat aattattatt cctattaaat ttggatgtaa taacgttttt 8161 ttaaagatta actcttagct tgttggcgat attctctaac tcgttactct tatcatcaaa 8221 aatatagttt tttattttaa ttatggttcc aggatggatt tttaattttt cagcgatata 8281 aatgtgattt ttcaataata agattgatcc aaacccatta gtcaattttt tatcaaaact 8341 atacattggt ttttgttcaa aacgataacc atagtgttct tcataatgat aatcatttct 8401 attctcataa tggaaagtga agtttatctt ttcgccaaaa ataagtataa acatactatt 8461 agcaatgttt atatcccaat ggtatgcgtc tgccaaacgt atgattattt cactgtccca 8521 attattaatt agtgactgta tattgtcttt ggcctgttct agttttatct cctcttcttt 8581 ctttttacct tctaactgaa tttttgattt ttcaaggttt gatacttcaa gtttaagtgc 8641 tttatacatg gggtgttctg gggggaacag tgttgcgcta ccatttctaa tatttatggt 8701 agaatcagct ctatctatat cgctatctat atcaccaata ttttttgcta ttgatcttag 8761 tactttttcg gctgcatttc ttaagttttc ttgtttttca tttgtaccag taatcagctg 8821 ttgcataatg tcgaataatt cgctttgcga cacctcagcc tcttgttgcc ataacttaaa 8881 ttcagataat aactttaaca gcgtgatact tggagaaggg gcacgacctc tattatcaat 8941 gccattgggt aataaaatta atgctatctc ttgttcagac aacattgccc attgcgcaat 9001 taatacatat tggctcagtt tttggcattg gagaatcaag ggctgatgga cttccaattg 9061 gtgcaatgaa ggctcttcag caaaggtcat ggaaatattt tgccaaaatc tttctaaggt 9121 aaattcagag tcattttttg ctaaccaatt gaccagccct gcgactacat tagcttttag 9181 gtggaagccg tttgccaagc tgcgatacag attaggtttg agcgattcgg aataaacttg 9241 cttacctaag gtttgataaa tattggataa gaaattaaat aattcagggg tcgctgtggt 9301 gctgtattgc ttggtgagca tggcttgtag ggtggtgata tccagttttt gctcactcat 9361 ccattgaagg gtattttcta gcacaataat ggcatcaata atggtcagag cattaccctg 9421 ggctattttt tccataatat tttcatctgg atggctatat aactgccata gatattcagc 9481 ttgcgagaaa ctcacaccaa gtgtgcgggg gatcattgcc atacggtata attggctgaa 9541 ttttttacta ttcatcttta cgttgctaat tgaactctta ccaaagcaat atttcgcaat 9601 acgtaacagt tcttcggcag taatgcccaa tgccttgcgg ataatcactt cccacgaacc 9661 ctgatcaagg aagttaaatc ctgcatctac atcaagggta gagaaaatct gctggaagaa 9721 actggtttta ttttcgttgg tatgggtggt gttaacggca ttaataatgg cgataaacgg 9781 atcgacagac aggccgtaac gctgatgtaa acggcgatat tcggagatga ctgcgagtat 9841 ttcgagtttg gctggatcat ttttattgct gctattttca atggcatttt tattaagcca 9901 ttgcagttgt tcaacactga gttgcgtggc atgtgccagg cgtttggcgt aactctcatc 9961 caatggggat tttatatcaa ttaattcata actggccgga ttcaatccca gttgttcttg 10021 tactaacgcg ggggtaatgg gattagccca tggatcatta ttctccgcta acagggctgc 10081 aatttctcgc agactagttg atttatcctg tagcaccgca ttaataaccg ttaggttatc 10141 gtcataaggc agggtaaaag aaacgtcatt tacgtgtgct tcggtatctt tagtcagctc 10201 atccagaggc gccttcgttt gcagtacatt gagtaagatc tccagcgaag agacttcttg 10261 attcatatta ctgttattaa gcaccagatc ttgtaaatca gggcggcgtt gatcgatatg 10321 cagtttgttt ccatcttcat gtagctcttt tgctacatga tacaattcgc ataaatagcg 10381 gcccggagag aacaaggatt ggatagatgc cggatcggca tactcatttg ctcgttctgg 10441 tattccttcg gccagtgaaa gatctgttct ggcttcaggc tgcaatattt ttggtgcaac 10501 agaaaaggcc agtttattga tgccactgag taccggatcg ttgcgtagct gtgttgcccg 10561 cctgacggcc tggcggtggc gctcttctgc tttggcttgc tgatgaatcg tattatcagt 10621 atccgtgata acggatgcag tatggtcgat attatcttgc ataatttacc tctatattta 10681 aggacattag cttgggatgt gaaatagcag gtgttaacga tgtgcttacc taaataactt 10741 gcctgcgtaa gttcctcgga attaattttt ctgcaactcc aactacttta gggataaaat 10801 gacgcgctat cgtttctgtt tggtgttttt attgttatct tctgtttaac taaattttag 10861 ttaaacaaat tgtatttaac tacgtgttgc atctgactta gtgttttttc tctgccttct 10921 gccactgcag gagtgaatta ttcgttatgt attggatgaa aaattctttg ttaattactg 10981 agcttttaaa gtaaatgtaa taggtaatgt caaagttgat atctgatata aaacttattt 11041 cggtagagtg acttatcttt tttttatcaa aaaaataatt tgtggatagc gagattcctg 11101 cccctttttt aattatttca tggcgaactc tggcatcatc aatacgcagt acattccctg 11161 agtagccttg ttgtattagg ttgtgtgaaa atcgcttaaa gcagcaggaa gagcaaaaaa 11221 tactactttg tataaagggc agtttcttta aatattcaac tctatcaggc aagtcattca 11281 aatgtgatgc atacagtaat tttatttcac aactggcggt tagctcagta tcgaaatcat 11341 agccttttat ctctttggta ctgatgacga tatccatttg actgatatca ccaatattct 11401 ctcttaactc aatgttaaaa ttaccttttt ttataaagta atcacatatc acgccagcat 11461 gatctgaatt caactgatag gtggcgatat ttataatacc atttttattc tttttgtaat 11521 tctttgttat ttcagttaat cgcacgtagg ttgggtaaat ttcttgataa aaagcagcgc 11581 cttccaatgt cagttttaat cccgatgttg tacgtgtgaa cagtttaaaa cccagttcct 11641 cttccagtat ttttaagctt ctactcatgg ggggcggtgt tgtgaatagt ttcaccgctg 11701 cattagtcaa cgatccctct tgaaccgtag taaagaatac gagtaaattt tttgatataa 11761 acatatgcac cacttattta ctattagttg tcgcgatatg tagatgtaca atatatctat 11821 aatataagtt aagtctattt catatattag aataattagt gttattttag tcaactaagg 11881 aggcgggtta gcaaaaatac tgtatgttag gtaatggtat ttcttacgta aattagcata 11941 ataaatatct tatttaacag ttgtttctta tttcaagatg atttttaatc atcaggttaa 12001 tttgttattt gatataacat accgttagcg ataatcctga taaacatcag ctacccgttt 12061 gaaatactcg gtcaaataat caatgcagac ctgaactttc agtggcattt tatctttttc 12121 agtataaagc gcatataccg ggcgcgggtc ggaatgatag tgtttaaata gaatctcaac 12181 ctcgccacgt ttaatttctt caatcaccca cattaaggga gcataggcga tacccgcccc 12241 ggcctttaac caacggatca tggtttgtga gtcattggtg acaaaacgac cctgcggtga 12301 tatttgggtg gtgatacctt ctggtgcgat cagctcaaaa ttgctatctg ggcggacgtt 12361 atactccaac caggaaaaat tggccatgtc actgggtttt gctggcgtgc catattgcga 12421 caaataactt tttgctgcac acaccaccat aggcatagca ccgaggcggc gcgaaaacag 12481 ccctgagttt tgcaaggcac cgacgcggat caccacatcc aggccatcag ctatcagatc 12541 cggtgcagga ataccggcaa ccagattcac tgataaaccg ggataggctt tgagcatatc 12601 ggctgtcatg gtggccagca cattttgtgc catggtggag gagcaaccaa tgcgtaatgt 12661 gccggttggg gtattattaa aggcatacaa ttgttcgtga acttgctgca cctcctgcaa 12721 catacgccgg cagccttggt aataaatccg gcccgcttcc gttaagccaa tacgtcgagt 12781 actacgattt agtagcttaa cgttaagctc attttccagt tttgataccg tttggctgat 12841 ggaagagaca ctgttctcca gtcgtcgtgc tgcggcagta aaagagccgc actccaccac 12901 cttcgcaaaa acagacatct gttttaatct ttccattact tattccatct gtattattaa 12961 ctctggctta aaagtgattt agatcacaca tcgtagataa cttgataata agcaggctaa 13021 tatactgttg tcgggagaat agcctcacgt tttgcttatc ggtgcgaata cggcaccacg 13081 ccgaagcgtt atcataattt attcaattca atagcttcag tttaacccat aagactgcct 13141 tatggctttt gctttgagtg cccagcaggt aagttgggtg ggtaggggca ttaacgcagg 13201 ctaaatgacc cgaaccttaa acataaagga tttaaagaat gagtttgctt ccggtgatgg 13261 tgatttttgg cctctctttt ccaccgatat ttcttgagct gctaatttca ttggctttgt 13321 tttttgttgt gcgccgcatc ctgcaaccaa ccggtattta cgagtttgtt tggcacccgg 13381 ctctttttaa tacggcgctg tattgttgcc tgttttattt aacatcccgt cttttttcct 13441 gaggtcacag tgagtacatt ttcattaaaa ataatccgcg ttggcatcac cgtcttggtg 13501 gtcgtactgg ctgttatcgc gattttcaac gtgtgggcct tctatactga atcgccgtgg 13561 acccgtgatg ctaaatttac cgcagacgtg gtcgctatcg caccggatgt cagcggctta 13621 ctgaccgaag taccggtaaa agacaaccaa ctggtgcaga aaggccagat tctgtttgtc 13681 attgatcaac cccgttatca gcaggcgttg gctgaagccg aggccgatgt ggcctattac 13741 cagaccctgg ctgcggagaa gcaacgggag tccagtaggc gtcatcgcct gggtattcag 13801 gcgctgtcac aagaagagat tgaccaggca agcaatgtgt tgcaaaccgt ccagcatcag 13861 ttggcaaaag ccattgccgt gcgggattta gcccgccttg atctggaaag gaccacggta 13921 cgtgcaccag cagaagggtg ggtgaccaac ctgaatgtac atgctggcga gtttattaac 13981 cgtggggcca cggcagtcgc attggtgaaa aaagatactt tctacatttt agcctatctg 14041 gaggagacga agctcgaagg ggttaaaccg ggctaccgag cggaaattac cccgctgggc 14101 agtaaccgca tcctgcatgg tacggtcgat agcatttcag ccggtgttac caatagcagt 14161 agcagtgccg acagcaaagg gctggcgacc attgataata atcttgaatg ggtacgcttg 14221 gcgcaacggg taccggtgaa gattcatctg gatagcgaag accagcaata tttgtatccg 14281 gcgggcacca cggccacggt ggtgatcacc gggccgaatg atcgtgatcc tcatcaggta 14341 tcgcccatga ccaagttgat gcatcgtcta cgtgagtttg gctaatatga cccacccaag 14401 ctttattcgc ctgcggtttg cgttcaagct gagttttgcc attgtggcgg cattatttct 14461 tggctttcat ctgcaattgg aaacaccgcg ttggtcagtg cttactgccg ctattgtttc 14521 cgccgggcct gccttcgctg caggtggcga acctttctct ggtgcgattc gccaccgagg 14581 ttggttacgg attatcggca cctttatcgg ctgtattggg gggctggtca ttattgtgct 14641 gaccatcaga gcgccagtat taacgttgat gctgtgttgc ctatgggctg ggatctgtac 14701 gtggatttca tcgctggtac gggtagaaaa ttcgtatgcg ttcggtttgg ccggttatac 14761 cgcgttaatc atcattgtca ccaccggtga aacgccacta ctgacgccgc aatttgcggt 14821 tgagcgctgt agcgaaattg tcctcgggat cgtctgtgcg gtgatggcag atctgctgtt 14881 ttcaccccgc tcgatcaaac aggatattga tcgattggtc gacaaggtgt tagtggatca 14941 gtaccggctc ttacaactct gcattcagcc agcagaaaaa agtgagattg atcgcgcttg 15001 gaatgaattg gttaaaaata ccacgtcact caatgggatg cgcagctatc tgatgatgga 15061 gtcttcccgt tggcagcggt gtaatcgccg tttgcaggtg ttacataccg agtctttggc 15121 gctgatcacg caggcgtgtg aaacctatct ggtgatgagc aatcacccag aggtgatcag 15181 tgctgaactg aaaactatgc tgagcgaacc cgctcaaact cctgcagaga tccaccagca 15241 gatgaaaaaa ctgcgtcagt ttattgctgc cagccacagt gaggcgatcc cgcacaccat 15301 cagcagttgg gttggggcag cgactcgcta tttattactg tcgaaaggga tccagaccaa 15361 cagcagcatc aatcaggtcg aagaggatat tttggcgggt gatgcgccgg ttaagcccat 15421 ttctgccgaa ggccatcatg cgatgatcaa tggcttgcgt accggtattg ccacggcgat 15481 tggtggcctg ttctggctgt ggaccggctg gacatccggc gcggggtgta tggtgatgat 15541 tgcagtggtc acttcgctgg cgatgcgaac accgaatcca cggaggatgg cgctcgattt 15601 tctggtcggc gtgattatcg cactgcccat cggggcgctt tactttatgt ttattatccc 15661 gtcgacccag caaagtatgc tgttgctttg tatcagcttg ggtgtgctgg catttattat 15721 cggcatcgaa gtacaaaaac ggcgcttggg ttcactggga acgctggcta gcaccataaa 15781 tattatcgtg ctaagtaatc caatgatatt taatgtccgc cagtttctcg atagcgcatt 15841 aggtcaaatt gtaggctgct ttgtctcttt aattgtcctg ctgttgatcc gtgacaacgc 15901 gaaggacaga acgggcagaa ccttactcaa ccgttttgtt tacagtgcgg tctcggccct 15961 aaccaccaat aaaaccaagc gcggcgaaaa tcatctaccc gcgctgtatc agcaactgaa 16021 ccagttattg atgatgttcc cggccgatat tgataaatat cgtctggcat taacgctgat 16081 tattgctcac cagcggttaa acaggactga aatcccggtg aatgcggagt tgagcgcttt 16141 tcataaacag atccgctcta ccgcagagcg agtgattact gtcaacaatg accagaaacg 16201 gcgttattat tttgcccggt tattgcagga actggatcaa tatcaacaga aattggtgga 16261 ttatcaggct gctgatgcgg ttatccgccc ggttaagcgg ttgactgaga tgttgcgtaa 16321 atatcagagt gcgctgattt aaccgataac ctacggacat aaggtgttct catcacctca 16381 tcaagggcta taataagttt ggtaccagac tgctgacaaa ccccgataat tcgatcttaa 16441 atggtgagga taggcaggga aggcgcggtt cgagccctca taaaggcgct cacggcgtct 16501 ttgttatttc tctcttctcc cgctgcaggc acgttgtcat caacctcggt accttccttc 16561 ttcgcctccc tttgatgggt ggcatcatct cctcaggagg ttgacactat gcccgcacaa 16621 aatcctttac aacatcaacg acagcacgac ggtatatacc acattggcta ttttgtcggt 16681 ggaaaatggt ctcaggcaca ggagcaattt gacgtctgca acccggcaac cggcgagctg 16741 gtcgccagag tggctaaatc cggtaaacaa gaaaccgaag cggcgattaa agctgccagc 16801 gaggctttcc ctgcctggcg aaaaacgccc gctaaacagc gagcagagat tttacagcgt 16861 tggtatttgc tgataatgga acatcagcaa tcattggcag agctgatggt ctccgagcaa 16921 ggtaaaccct taaaagaagc cttggttgaa gtggcttatg ccgccagttt tatccaatgg 16981 tttagtgagc aggccaagcg ggctaacggt gaaattatcc cgtcagccaa agagggcgca 17041 cgtatcctgg cgacccgaga acctattggt gtggtagccg ctatcacacc gtggaatttc 17101 ccgctcgcga tgctcacccg caaactgggg ccagcactgg ccgccggttg taccgggctg 17161 attaaacccg ctaataacac gccattatct gccttcgcct tactggcact ggcagaacag 17221 gctggcgtgc cagctggggt actcaatggt gtcgtggggg atactcatgc tatcagcgac 17281 gcgattatgg ccagttcaga cgtgcgtaaa atctctttta ccggctcaac caatgtcggt 17341 aagacgctga tgcgcaatgc tgctgcaacc atgaagagaa tttcgatgga gctgggcggt 17401 aacgcgcctt acatcgtttt tgatgatgcc gatttagagg cggcggtcgc cggggctatg 17461 gcgtgtaaat tccgtaatgc cgggcaggtg tgtgtgtgcg tcaatcgctt ctatattcag 17521 gatgctatct acgacgagtt tgttaaccgc ttggctgccg aggtgaaaaa actgaaggtc 17581 ggcaacggga tggataaaga cgtcaacatg gggccgttga ttaatttggc tggtctggag 17641 aaagtagaag agcacgtaaa agatgcgctt gagaaggggg ggcgtctttt agcggggggg 17701 catcgccatg cgctgggcgg taatttcttc cagccaacgg tgattgcaga tgccaatgag 17761 cagatgaaag tggcctcgga agagacattt ggcccgctgg ccgcctgctt ccgtttcagc 17821 actgaagccg aagtgattca acgggccaat aatacgccat ttgggctggc ggcctatttc 17881 tatacgcaga acttgcaacg ggtgttccgc gtttcagagg cgttggaaag cggtatgatt 17941 ggcgtcaatg aatgctcggt ttcgaccgag ttggcccctt tcggtggtgt taaagagtct 18001 ggcctaggtc gtgaaggttc ggtgctgggg ttggatgaat ttatggaagt gaaaaccctg 18061 catttgggta acttgtagac aaccttgtcg gtcgagttaa tgggttagcg ttaagtataa 18121 gttgtaataa tgatatgtga tatgaatagt cataatgata tgaatggtcc taatggcatt 18181 aattgtagga atgatattaa ttgtaggaac gatattaagg gcaacaatga gtagtaccgc 18241 cgtggtaggg agcctgggga ttaaggggat ccatgaataa acgactgatg gccatactgg 18301 gtgctgtgct gctattgata gcaggtgcat ggcaagggat tgatggcgta acggtgcgtg 18361 atattggttc ctcggcagag cttgagcgcc cggcgctttc ggcctctgcc gctactgaat 18421 cgttaacgca acaccagaaa gtggtgaaat acttacaaac gcaccatcgg ctaccggatt 18481 tttacctgac gaagaaacag gcccgtgagc aaggctggga tgcccaaaag gggaacctct 18541 gtgacgtgtt accgggcaaa gccattggcg gtgatcgttt ctccaaccgt gagcgtcagt 18601 tgcctgacgc caaaggccgt cattggcgag aagctgatgt gaattaccgc tgtgggcgtc 18661 gtggtagtga tcgcttgctg tactccaatg atggcctgat ttatctgacc caagatcact 18721 ataagcattt cattcggatg gagtaa //