LOCUS NC_009697:8 19340 bp DNA linear BCT 08-SEP-2013 DEFINITION Clostridium botulinum A str. ATCC 19397 chromosome, complete ACCESSION NC_009697 SOURCE Clostridium botulinum A str. ATCC 19397 chromosome, complete COMMENT locus start: 1336889; locus end: 1356228 COMMENT n1_4mer:GRV/n1_4mer:RV = 3.252964; n0_4mer:D = 18.967656; n0_4mer:PS = 34.824583 FEATURES Location/Qualifiers source 1..19340 /organism="Clostridium botulinum A str. ATCC 19397 chromosome, complete" gene 1..228 /gene="" /locus_tag="" /db_xref="1336889..1337116" CDS 1..228 /gene="" /product="rubredoxin" /translation="MIKVYTAEGCPWCTKAKTYLKTKGIAFQELNIEKDEKARDEMVQ KSSQRGVPVLDIDGSIIIGFNKPAIDEAINL" gene complement(260..1720) /gene="" /locus_tag="" /db_xref="1337148..1338608" CDS complement(260..1720) /gene="" /product="glyceraldehyde-3-phosphate dehydrogenase" /translation="MFKNLYVENNLYKNFIGGQWVNSKTNNFIEISSPIDGSLVGKVP SMSKEEVDLAIKNAKKAQSHWNEIPINEKATILLKAANILDEKAEEIADIMTKEIAKD KKSSISEVRRTADYIRFSADTAKNMVGETLPGDSFPGNSKGKISIVNRVPLGVVLAIS PFNYPVNLSGSKIAPALMAGNSVVLKPATQGSISALHLVKVFEEAGLPSGVLNTITGK GSEIGDYIVSHPMIDFINFTGSTEVGKRISHISVMKPMLMELGGKDAAIVLEDADLDL AAKNIVSGAYSYSGQRCTAVKRILVLEEIADTLVEKVKERVESLKIGNPLKEQVDIVP LIDDKAADYVEALMEEANNKGATLLVGGKREGNLIYPTLFDNVTLDMRLAWEEPFAPI LPIIRVKDVDEAIRIANESEYGLQASIFTKEINKAFYVAEKLEVGTVQINNKPERGPD HFPFSGIKASGLGTQGIKYSIEAMSRPKAIVLNINL" gene complement(1760..2701) /gene="" /locus_tag="" /db_xref="1338648..1339589" CDS complement(1760..2701) /gene="" /product="thioredoxin reductase" /translation="MNKKNKNLDLMIIGAGPAGLSAAIYAARAKLNMILIENGIIGGQ VRSSYTVENYPGFKKIEGNRLADLMQEQATDLGATIDEFDMVEKIQLNNNEKIVETSE YIYKPTVLIISTGATARKLPIPSEGKFSGKGIHYCAICDGAMYEGKTVGVIGGGNAAL EEALFLTKFASKVYMIRRYDYFKGEKATLEEVENNSKIEILYNWDLVDVYGSNFIDKA LIKNVKTKEEKELKLDGVFGFIGSEPKTELFKEYISLTPKGYIKTNENMETNIKGVYA AGDVREKQFRQITTAVADGTIAALAAEKYIMEKTREK" gene 3498..3875 /gene="grdX" /locus_tag="grdX" /db_xref="1340386..1340763" CDS 3498..3875 /gene="grdX" /product="GrdX protein" /translation="MNNKVIMVTNNKLVSEKFNEKCQVEFILGDVNEVFNTVRDYVHK GHELLTHPLMSSVKPNETPYRTVVISKYYKNVVDMESLNYIEESIHSLEKFQKSCGTP AWNDNILKDFRLIDYDLIYNALN" gene 3966..5252 /gene="grdE" /locus_tag="grdE" /db_xref="1340854..1342140" CDS 3966..5252 /gene="grdE" /product="glycine reductase complex component B, alpha and beta subunits" /translation="MRLEIGKIFISDMQFSNETKVKDGVLYISKEELLKEIGTDERIK SIDLEIAKPGDKTRIIPVKDVIEPRVKVEGNGGIFPGFISKVDTVGSGKTNVLKGAAV VTTGKIVGFQEGIIDMSGEGAKYTPFSKTNNLVVVCEPKEGVNQYEHEEIVRTLGFKA ATYLGSLAKDITPDETKVYETLPLLEQVKKYPDLPKVVYVYMLQSQGLLHDTYVYGVD AKKIIPTFIYPTEVFDGAIVSGNCVSACDKNPSYVHMNHPVIEDLYEKHGVEYNFLGC VITNENVYLADKVRSSSYTAKLVEFLGADAVIISEEGFGNPDADLVMNCNKISEKGIK TVLITDEYAGQNGASQSLADSTPKGDAVVTGGNANEVVTLPPMEKIIGHVEVADVIAG GHVGSLKEDGSIEAEIQVITGATSEVGFNYLSAKGY" gene 5285..6586 /gene="grdB" /locus_tag="grdB" /db_xref="1342173..1343474" gene 6737..7678 /gene="trxB" /locus_tag="trxB" /db_xref="1343625..1344566" CDS 6737..7678 /gene="trxB" /product="thioredoxin-disulfide reductase" /translation="MDNVYDLIIIGSGPAGLSAGLYAARARLKTLILERNKAGGQIVI TDEVANYPGSIRDATGASLVARMEEQVDEFGAERKKDNVKEVDFTGKIKIIKGEKEEY KAKSVIIATGAAPRHIGCKGENELIGKGVSYCATCDADFFTDLEVFVIGGGDSALEEA LYLTKFARKVTVVHRRDALRGAKSIQEKVFKNPKIEIMWDSVVEEIKGDGIVESAVFK NKKTGEITEYFADEDDGTFGIFVFVGYLPINNLFKDIVTINEAGYIKTNDRMETNIEG IFAAGDIREKSLRQVVTAAADGAIAAVEAYKYVEDTF" gene 7712..8032 /gene="" /locus_tag="" /db_xref="1344600..1344920" CDS 7712..8032 /gene="" /product="thioredoxin family protein" /translation="MLVVDKKTFEDEVLKSDGYTLVDYFGDGCVPCEALMPDVEELSQ KYEDKVKFCKLNTSKARRLAISQKVLGLPTIILYKDGEKLEEVVKDDATKENIEAMIK KHTL" gene 8118..8594 /gene="grdA" /locus_tag="grdA" /db_xref="1345006..1345482" gene 8689..10227 /gene="grdC" /locus_tag="grdC" /db_xref="1345577..1347115" CDS 8689..10227 /gene="grdC" /product="glycine reductase complex component C subunit beta" /translation="MNYPVIKGASYILVHTPDMVLHNGTTQTTEKVVNPDSEYLKELP KHLRNFEDVLNYAPNQTYIGNMTPDQLGEIEMPWWDKKIEESSRFGKLGEMMPQDEFI GLMEICDVFDLVVLEKSFVGDVKNKLEKHPLIDENMISKIKEGVAIEEIKKVVDEEGA EGLYNEGTLVGCVKKAHDVDVNLSAHTMLENLVVKASGVLSLLNLIAKNNIDPNSIDY VIECSEEACGDMNQRGGGNFAKSLAEVAGFTNATGADMRGFCAGPSHSLIAASALVQS GVYDNVVIAGGGASAKLGMNGKDHVKKEMPILEDCLGGFAVLVSKNDGINPILRTDLV GKHTVGTGSSPQAVISSLVTDPLDKAGLKITDVDKYSVEMQNPDITKPAGAGDVPQAN YKMIGALGVKKKHIEKKELKDFIQNHGMSGWAPTQGHIPSGVPYIGFARNDLTEGNLN RVMVVGKGSLFLGRMTNLFDGVSIIIERNTGYKEEEKGISEDKVRKIIAESIKKLASQ LVEE" gene 10243..11409 /gene="grdD" /locus_tag="grdD" /db_xref="1347131..1348297" CDS 10243..11409 /gene="grdD" /product="glycine reductase complex component C subunit alpha" /translation="MDNKEVNKIIGKTLLDIAESIEKGDFSRKIVVGITTLGSEHGVE NLVKGAEVAAKKHNDIKVVLIGPKVDTELEIVEANEEDKMYNKMEELLDTKYIDAAVT MHYNFPIGVSTVGKVVTPADGKEMFLATTTGTASMNRTEAMIKNAVYGIITAKTMGIK EPNVGILNLDGARQVEKALKELDKNGYKINFANSLRADGGSVMRGNDLLKGTPDVMVT DTLTGNLLMKVFSSYTTGGSYEGFGYGYGPGIGEDYERNILILSRASGVPVVANAIEY AKDLVKGNINKLIKEEFKKANEAKLKDILSSIENKEDKKIKDEEEVPMPTKEIATASI SGIDVMDIEDAQKTLWKEGIYAEGGMGCTGPVIKVNDKNYDKAAEILTEKGFIA" gene 11836..12447 /gene="" /locus_tag="" /db_xref="1348724..1349335" CDS 11836..12447 /gene="" /product="3-methyladenine DNA glycosylase" /translation="LRLTRDFYAKDARVLAKELLGKVLVREVDGIKLKGKIVETEAYI GAIDKASHAYGGRRTKRTEPLYGKPGIAYVYFIYGKYFCFNIISKTEGEAEGVLIRAL EPLENINLISKLRFNKEFEELNNYQRKNITSGPSKLCMAFNINRDNNWEDLCESSSLY VEDVFYNDFEIIETVRVGIDYAEEARDFLWRYYIKDNAFVSVK" gene 12513..14738 /gene="" /locus_tag="" /db_xref="1349401..1351626" CDS 12513..14738 /gene="" /product="restriction endonuclease family protein" /translation="MGGSYNLYKIKDISCISKYCNCLQLVFEDLYDLKKYFNENKTLF CNKALYVLINKIIISKIFMEKNNITGELAKKNIKYYALTLDTINLVNLVFDNVDKRFL ESIFKDNIKYEYINPSYYSLDKEDFLHYEDNIFYRYNIFLNKIIDEINGFDFIHSSCE IGEIYEKIIAKEYKKSMGIFYTPEYIIDYILENVFYEFSPLENPFVKLIDISAGAGYF IIKAYDKLKKVFTENIQNLQEKYKQNIYTIRKKGQSIKVTGEYYWQKENLHYHIINNC IYAADIDIYAIQITTINLLLKDTKSYVGKVNVANCDSLIRWEKDFNPTIKFLDNKYKY KTYKIKNKGIEEAVNYKEKEVCNWKTYFKLYKFWRKKFDYIIGNPPWVSLSRKNKKAC WKNSLEYYIKNYGQCVHSPNLFEYFIKRALEKTKKDGYLAFVVPINFSRNSQYIQLRN EILNKYEIKNLFFNIAFSGVITDGMVFILKKNKKCFNEIKIKVQGKDEYKIDKNELFS CNEYGFTFNNNDFDEKIKNKILENSSFLSEISDTFTGFIGDCKNIYKENVDKSYIKIY KGKNIKKFICYSYFYYDFKDENIKGGTKDLKKLKYKGKILVRKTGNEIIAAYDEEGII IEQSLYGIINLKQNFSHKYILGILNSQLMSWYYKKYLITNKDSTPQLKKYRLNKIPIK NCNKNVQEEVEILSDKIFQALKNENVKEIDYYYKILNQKVFSIYGIDDIKIIRYIIND K" gene 15174..16385 /gene="mtnK" /locus_tag="mtnK" /db_xref="1352062..1353273" CDS 15174..16385 /gene="mtnK" /product="methylthioribose kinase" /translation="MAEYKPMDCESIIKYIKELNLDIFDEKMDLTAKEIGDGNLNLVF RVKDNNTGKSVIIKQALPYLRVAGEGWKLTVDRNRIEAEAMMKQDKACPNSVPKIYYH DKDYNLYVAEDLGSMDILRNGLMNMKKYPKFPDQIGKFLSRNLFYTSDLGLGAVAKKS LVSKFINPELCDITEKLVLTDPYMNAESNDINPEIMDEVKDMWGRKDFRLEVTKLKNI FMTKAEALLHGDLHTGSIFITEDDMRVFDTEFAFYGPYGYDIGLLFANFILNYISWEG REDRSKEEIKEFRKYLLDTIEEIWHEFEIGLKEIWDKDCKEISSTVEGYKEYYINNLL QETIGFSACEVMRRIIGMAHVPDLDVLKDLKQKAKAQRLGLKIGQEMVMRRNKITKIE DLSVFISQITK" gene 16525..17574 /gene="mtnA" /locus_tag="mtnA" /db_xref="1353413..1354462" CDS 16525..17574 /gene="mtnA" /product="methylthioribose-1-phosphate isomerase" /translation="MAELLAIKWDDNRDKLILLDQTILPNKIEYIEYDTAEGVYDSIK DMIVRGAPAIGVTAAYGLYFAAKVAPEDKFENFFKYLKEKSSYLDSSRPTAVNLSWAL KVMESKALENKDKDVKEIKSILREEAKRIHEEDIEICKTIGENLITLLKDGVGILTHC NAGQLATSKYGTATSPMYLAKEKGWNFKVYSDETRPRLQGSTLTALELYEAGIDVTTI TDNMAAMVMSQGKIDAVIVGCDRIAANGDTANKIGTMGVSILAKYFGIPMYIAAPTPS IDINTKTGEDIPIEERNPEEVTSRFGVWTAPKGVKVYNPGFDVTPHENITAIVTEKGI VYPPFKENLKKLFEK" gene 17598..17708 /gene="" /locus_tag="" /db_xref="1354486..1354596" CDS 17598..17708 /gene="" /product="hypothetical protein" /translation="MVELLNIKNIKKSFSDVQVLHEINNLGILSPNLLIT" gene 17725..18372 /gene="" /locus_tag="" /db_xref="1354613..1355260" CDS 17725..18372 /gene="" /product="aldolase" /translation="LNNETYLRLQIVEVGKRLQQRFFVASNDGNISAKLDENTILITP TGVNKGEVTPDQIIKVDREGNVIEGHMKVTSEIKMHLAVYNMREDVKAIVHAHPPAST AFSVSKEKLDDPVILPEAVFSLGKIGYCEYGTPSTDEVPKAIEKEIPYSDVLLLSNHG ALTVGTDVMQAYYRMENLEMVSKVTIYSKMIGNIKTLNELQVEKLNKVKEEKGWG" gene 18416..18556 /gene="" /locus_tag="" /db_xref="1355304..1355444" CDS 18416..18556 /gene="" /product="hypothetical protein" /translation="MPVIEPLCLNFVKSGVMYKLYYNLMVFCFIINYKIKILGIGGKY ET" gene 18546..19340 /gene="" /locus_tag="" /db_xref="1355434..1356228" CDS 18546..19340 /gene="" /product="DeoR family transcriptional regulator" /translation="MKLKPEIRREKILAEIEKNKTVDIMELSEKLQVSEMTIRRDLKR LESSEKLLRTYGGATRISEGECKKVIDDPLKGRVLKNKDEKAIIGKYAGELVENDDVI MIDASTTALAICKYIRDKKVTVVTNSISVVTALASFDNITVVVACGILRHSSLSLVGS YVEESFKKFNIKKSFISAKALSFEAGLTDINAFEVETKKAAMSVSKEVIVLLDHSKLN NISLLKVCETKEISKIIIDGLKEFTVEEEELLNKFKSNGIEVIIAK" ORIGIN 1 atgattaaag tatatacagc agaaggatgc ccatggtgca caaaagcaaa gacatattta 61 aaaacaaaag gaatagcatt tcaggaacta aatattgaaa aagatgagaa ggcaagagat 121 gaaatggttc aaaaatcaag ccaaagaggt gtacctgtat tagatataga cggatcaatt 181 ataataggat ttaataaacc ggctatagat gaagctataa atttataaaa taaggaagtt 241 gcgatgcaac ttccttattt tataaattta tattcagaac tatagcttta ggtctagaca 301 tagcttctat ggaatatttt ataccttgag taccaagacc ggaggcttta atacctgaga 361 atgggaaatg gtctggtcct ctttctggtt tattattaat ttgaactgta cctacttcta 421 acttttctgc tacataaaag gctttattta tttcttttgt aaatatagag gcttggagac 481 catattcgga ttcattagct attcttatag cttcatctac atctttaact cttattattg 541 gaagtattgg agcaaagggt tcctcccaag ctaatctcat atctaatgta acattatcaa 601 ataaagtagg ataaattaaa ttaccttctc tttttccacc tactaataat gtagcccctt 661 tattattagc ttcttccatt aaagcttcaa cgtaatctgc agccttatca tctattaaag 721 gaacaatatc tacctgttct tttaaaggat ttccaatttt tagagattct actctttctt 781 ttactttttc aactagtgta tctgctattt cctctaaaac tagtattctt tttacagcag 841 tacatctttg accagaataa gagtaggcac cagatactat atttttagct gctaaatcta 901 gatccgcatc ttctaaaact atagcagcat cttttcctcc taattccatt agcataggtt 961 tcataacaga aatatgggat attctttttc ctacctctgt gcttccagta aaatttataa 1021 aatcaatcat aggatgagaa actatataat cacctatttc actaccttta cctgtaattg 1081 tatttaaaac tccagaaggc agaccagcct cttcaaaaac ttttaccaaa tgaagagcac 1141 ttatgctacc ctgagtagca ggttttaaaa ctacactatt tccagccatt aaagctggag 1201 ctattttaga gccagataag ttaacgggat agttaaaggg agaaatagct aaaactacac 1261 ctaagggtac tctattgact atagatattt tccctttgga atttcctgga aaagaatctc 1321 caggtaatgt ttctcctacc atattttttg cggtatctgc agaaaatctt atataatcag 1381 cagttctacg gacctctgaa atagaacttt ttttatcctt agcaatttct ttagtcatta 1441 tatcagcgat ttcctcagct ttttcatcta atatattagc agcttttaat aggatagttg 1501 ctttttcgtt tataggtatt tcattccaat gggattgagc tttcttggca ttttttatag 1561 ctaagtccac ttcctcttta ctcatggagg gaactttacc taccaaagag ccatctatag 1621 gagagcttat ttctataaag ttatttgttt tactatttac ccattgtcct cctataaaat 1681 ttttatataa attgttttct acgtataaat ttttaaacat atagacacct ctaatctttt 1741 cttttgtaat atataaatat tatttttctc ttgttttttc cataatatat ttttcagcag 1801 ctaatgcagc aatagttcca tcagctacag cagtagttat ttggcgaaat tgtttttctc 1861 taacatctcc agcggcataa acacctttta tattggtttc catattttca ttagttttaa 1921 tatatccttt aggagttaaa gatatatatt ctttaaataa ttctgtttta ggttctgaac 1981 ctataaatcc aaaaacccca tctaatttta attctttttc ttcttttgtt ttaacatttt 2041 taattaaagc tttatctata aaatttgaac cataaacatc tactaaatcc cagttgtata 2101 atatttctat tttagaattg ttttcaactt cttctagtgt ggctttttca cctttaaaat 2161 aatcatatct tctgatcata tatacttttg aagcgaattt ggttaaaaac aaagcttctt 2221 ctaaggcggc atttccaccg ccaattactc caacagtttt gccttcgtac atagcaccat 2281 cgcaaatagc acagtagtgt atacctttcc cagaaaactt accctcacta gggataggga 2341 gctttctagc tgtagcgcca gtagatataa ttaagactgt tggtttgtat atatattctg 2401 aagtttcaac tattttttcg ttattattta attgaatttt ttctaccata tcaaattcat 2461 ctatagtagc accaagatct gtagcttgct cttgcattaa atctgcaaga cggttacctt 2521 caattttttt aaatccagga taattttcaa cggtataact acttctaact tgaccaccaa 2581 ttattccatt ttcaattaaa atcatgttaa gcttagctct agcagcatat atagcagcag 2641 ataatcctgc aggacctgct cctataatca ttaaatctaa gtttttattt tttttattca 2701 tataaaatca ccccttatta cccttatagg gtatatatta attatactac tttttttgtg 2761 tttcacaata taattaataa aaattattaa taaaaaaata ttattataaa aataaataaa 2821 atattattaa taggttaacc atttaaaata aataaaatta ttataaaatg taattaatta 2881 ttagagtttt taatataaat aaaaaaacaa tataaatata gaaataaaaa gcataaatct 2941 gcataagata tcatagcttt tattatagaa aaatttatta tcaataaatt taataaaatt 3001 tcataaaaat gatgtaataa atgatgtaat aaatgatgta ataatagaaa atttttatat 3061 ggacataaaa aatctataag gaatacttat agtcactatt tggaaacaaa attcactatt 3121 ttctgaaaag tatgtaaaat aatattgaaa tgaggtataa tatagttaaa tatttaataa 3181 agtttggatg aaattttcgg gagattaagt tttagactta gctatgtaga ttttaaaata 3241 aatattaatt ctacgtggta tccttatagg atagccgaag gaactaagtg ttattcccat 3301 aaataacatg aatatctcag gcaaatggac cgaaaattga caaaactctg gaaagcatta 3361 cgcaccgaag gagcaaaact ctcaggttaa gatacagaga taaaagttat ggacttttat 3421 ctctgttttt ttgtgcaaat aaaaacttta taatttacta agaaattata aaaataatgg 3481 acagggtggt gggctgaatg aataataagg ttattatggt aactaataac aaactagtta 3541 gtgaaaagtt taacgaaaaa tgtcaagtag aatttatact aggtgatgtg aatgaggttt 3601 ttaatacagt gagagattat gtacacaaag ggcatgaact tttaactcat ccattaatga 3661 gtagtgtaaa gcctaatgaa acaccctata gaactgtagt tatttcaaaa tattataaaa 3721 atgtagtgga tatggagtct ttaaattata tagaagaatc tatacattcc ttagaaaaat 3781 ttcaaaaatc atgtggtact cctgcatgga atgataatat cttaaaagat tttagattga 3841 ttgattatga tcttatatat aatgcactaa attaatttta tataagattt atataaaaat 3901 tgctagaatc atttagcagt acaataaaga taaggcatta aaaatttaat ttgggggttg 3961 atattatgcg tttagaaatt ggaaaaatat ttataagtga tatgcagttt tccaatgaaa 4021 caaaagttaa agatggagtc ttgtatattt ctaaagaaga acttctaaaa gaaattggta 4081 ccgacgagag aattaaaagt attgatttag aaatagctaa gccaggagat aaaactagaa 4141 ttattccagt aaaagatgta atagagccaa gagttaaagt agaaggaaat ggtggtattt 4201 tcccaggctt tataagtaaa gttgatactg ttggttcagg caaaactaat gtattaaagg 4261 gagccgcagt agtaaccaca ggtaaaatag tagggttcca agaaggtatt attgatatga 4321 gtggggaagg agctaaatat acaccttttt caaaaactaa taatttagtt gtagtatgtg 4381 aacctaaaga aggagtaaat caatacgaac atgaagaaat tgtaagaact ttagggttta 4441 aagctgctac ttatttaggt agtcttgcaa aagatattac accagatgaa actaaggttt 4501 atgaaacatt acctttatta gaacaagtaa agaaatatcc agaccttcct aaggtagtat 4561 atgtttatat gcttcaaagc caaggacttt tacatgatac ctatgtatat ggagtagatg 4621 ctaaaaaaat aataccaaca tttatatatc caacagaagt atttgatggt gccatagtta 4681 gtggaaattg tgtttcagct tgtgacaaga atccaagtta tgtacacatg aaccatcctg 4741 ttattgaaga tttatatgag aaacatggag tagaatataa ttttttaggt tgtgttataa 4801 caaatgaaaa cgtttatttg gcggataaag ttagatcttc aagttataca gctaagttag 4861 tagaattttt aggagcagat gcagtaataa tttcagagga aggttttgga aatccagatg 4921 cagaccttgt tatgaattgt aataagataa gtgagaaagg tataaaaaca gtattaataa 4981 cagatgagta tgcaggacaa aatggagctt cacaatcctt agcagattct acaccaaagg 5041 gtgatgcagt agttacagga ggaaatgcta atgaggttgt aacattacca ccaatggaaa 5101 aaattattgg tcatgttgag gtagcagatg taattgcagg tggacatgtt ggttctttaa 5161 aagaagatgg ttctatagag gcagagattc aagttattac aggagctact agtgaagttg 5221 gctttaacta tttaagtgct aaaggctatt aaattgtagt tatataatca aggggggaaa 5281 ataaatgatt aaagtagttc attatataaa tcagttttat gcgggtattg gaggagaaga 5341 caaagcggat tataaaccag aagtaagaga ggaacctgta ggtccaggaa cacaacttaa 5401 ttctttattt aaaggtgaag ctgaaatagt tgctacggtt atttgtggag attcatattt 5461 taatgaaaat atagatgaag ctaaaaacac tattttagaa atgattaaaa aatatgatgc 5521 ggatttgttt atagcaggac ctgcttttaa tgccggaaga tacggagtgg cttgtggaac 5581 tattgcaaag gaagtagagg aaaaattaaa tataaaggtt ttaacagcta tgtatgaaga 5641 aaatccagga gtagatttgt ataaaaaatc tttatatatt cttaaaacca agaaaagtgc 5701 agtaggtatg agaaaagcat tacctgttat ggcaaaactt gcattaaaaa tgggaaaagg 5761 ggaagagata ggacttcctg aagaagaagg atatatagag agaggcataa gaaaaaatta 5821 ctttagtgat gaaaggggat ctaaaagagc agtaaatctt cttgtgaaaa aattaaaagg 5881 cgaagaattt gttacagagt ttaaaatgcc ggtttttgat agggtagaac ctaataaagc 5941 tgtagaggat atatcaaaat gtaaaattgc tattgtaact tctggtggaa tagtaccaaa 6001 gggaaatcca gatcatatag aatcctctag tgcatcaaaa tatggtaaat atgatataga 6061 aggacttatg gatttaaatt cagaaactca tgaaactgca catggaggat atgatcctaa 6121 ctatgcaaat gaagattcag acagagttat acctgtagat gtattaagaa aaatggagaa 6181 ggaaggaaaa ataggatctc ttcatagata tttctatagt actgttggaa atggtacagc 6241 agtagcatct tctaaaaagt ttggaaatga aatagtaaat cagttaaagg aagatggtgt 6301 tgatgcagtt atattaactt ccacatgagg aacttgtact cgttgcggtg caacactagt 6361 aaaagaaata gaacgtggag gacttccggt tgtgcatatg tgtacagtag ttccaatttc 6421 tcttacagtt ggtgctaata gaatagttcc gactatagca atacctcatc cacttggaaa 6481 tccaaattta gataaagaaa gagaatttga attaagatat aagcttgtag agaaagcatt 6541 aaaggcgtta gaaacagaaa tagatgaaca gaaagttttt gaatagaagt tttaataaaa 6601 gtaattttaa gtaaatttta tatagttcaa agacgattta ataggtctta aatagtttca 6661 cgtgttaatt ttatttaaat aattagattg gtaaaaatat aatttttaag tattaaattg 6721 tgggggggag caagatatgg acaatgttta tgatcttata attataggct ctggtccagc 6781 aggactatca gcaggtttat atgctgcaag agctagatta aaaactttaa tattagagag 6841 aaataaagca ggtggacaga tagtaataac agatgaagtg gctaattatc caggatctat 6901 aagagatgct acaggagcaa gtttagtagc tagaatggaa gaacaagtgg atgaatttgg 6961 agcagaaaga aaaaaagata atgttaaaga ggtagatttt actggcaaaa taaaaattat 7021 aaagggagaa aaggaagagt ataaggcaaa atctgtaatt atagctactg gtgctgctcc 7081 taggcatata ggctgcaaag gtgaaaatga attaatagga aagggagtat cctattgtgc 7141 tacttgtgat gctgactttt ttacagattt agaagttttt gtaataggtg gaggagattc 7201 agctttagaa gaagccttat atcttactaa gtttgcaaga aaggtaacag tagttcatag 7261 aagagatgct ctaagaggag ctaaatcaat acaagaaaaa gtatttaaaa atcctaaaat 7321 agaaattatg tgggattctg tagtagagga aataaaaggc gatggaatag tagaatctgc 7381 agtatttaaa aataaaaaaa caggagaaat aactgaatac tttgcagatg aagatgatgg 7441 aacttttgga atatttgttt ttgtaggata tttacctata aacaatttat ttaaagatat 7501 tgttactata aatgaagcag gatatataaa aactaacgat agaatggaaa caaatataga 7561 gggtatattt gctgctggtg atataagaga aaaatcatta agacaggtag ttactgcagc 7621 ggcagatggt gctatagcag cagtagaagc ttataaatat gttgaagata ctttttaaat 7681 ataaaaaatt tatttgaaag gcggttataa aatgttagta gttgataaga aaacttttga 7741 agacgaggta ttaaaatcag atggttatac gttagtagat tattttgggg atggttgtgt 7801 tccatgtgag gctttaatgc ctgatgtgga ggaattatca caaaaatatg aagataaggt 7861 taaattctgc aaattaaata cttctaaggc tagaagactt gctatatctc aaaaagtttt 7921 agggcttcca actataatct tatataagga tggagaaaaa ttagaagaag tagttaaaga 7981 tgatgctaca aaagaaaata tagaagctat gataaaaaaa cacacactat aaaattttaa 8041 agattattta gtcatttaaa gtgtgtatat aaatatcaag gaatttaaaa tataaataaa 8101 ttaagggagg aattttaatg agtctatttg aagggaaaaa agtaataata attggagata 8161 gagatggaat accaggtcca gctatagaaa aatgcataga aggtacaggc gctgaagtag 8221 ttttttcatc cacagaatgc tttgtttgaa ctgccgccgg agcaatggat ttggaaaatc 8281 aaaaaagagt aaaaacatta acagaaaaac atggtgctga aaatatatta gtaattttag 8341 gtgcagcaga gggagaagca gcaggtcttg ctgcggagac agttactaat ggagatccaa 8401 cttttgcagg tccattgtcc aatgtccagt taggactaag ggtttatcat gcggtagaac 8461 cagaatttaa agaagaagtg aatgaagaag tttatgagga agaaataggt atgatggaaa 8521 tggttttaga ggtagatgaa attatagaag agatgacaga tataagaaca gagttttgta 8581 aattccttga ttaaaacagg gaaagtagat aaataaagaa ttataaaatt taagaggctg 8641 tactataggt ttataatcca gcctcctaaa tattaggggg gaaaagctat gaattatcca 8701 gtaataaaag gagcatcata tattttggtt catactccag atatggtact tcataatgga 8761 actactcaaa ctacagagaa agtagttaat ccagattctg aatatcttaa agaacttcct 8821 aagcatttaa gaaattttga agatgtttta aattatgcac ctaaccaaac ttatatagga 8881 aacatgacac cagatcagct aggtgaaata gaaatgcctt ggtgggataa aaaaatagaa 8941 gagagtagta gatttggcaa attaggcgaa atgatgcctc aagatgaatt tataggactt 9001 atggaaatat gtgatgtatt tgatttagtt gtattagaaa aatcctttgt aggggatgta 9061 aaaaataagt tagaaaaaca tccactcata gatgaaaaca tgatttctaa aataaaagag 9121 ggagtagcta tagaagaaat caaaaaagtt gtagatgagg aaggggcaga aggcttatat 9181 aatgaaggta cattagtagg ttgcgtaaag aaagctcatg atgtggatgt gaatttaagt 9241 gctcatacta tgctagaaaa tttggtggta aaagcttctg gtgtattatc cttattaaat 9301 ctcatagcta aaaataacat agatcccaat tccatagatt atgttataga atgctctgaa 9361 gaagcgtgtg gagacatgaa tcaaagagga ggaggaaact ttgcaaaatc tcttgcagaa 9421 gtagcgggat ttactaatgc tacaggagcg gatatgagag ggttttgtgc aggaccgagc 9481 cattctctaa tagctgcttc agctttagtt caatccggag tatatgataa tgtagttata 9541 gctggcggag gggcaagcgc taagttaggt atgaatggaa aggaccatgt aaaaaaagaa 9601 atgcctatac tagaggattg cttaggtgga tttgctgtat tagtaagtaa aaatgatggg 9661 ataaatccaa tacttagaac ggatctagta ggaaaacata ctgtaggaac aggatcctct 9721 ccacaggcag taataagttc tttagttaca gatccattag ataaagcagg attaaaaata 9781 actgatgtgg ataaatattc cgtagaaatg caaaatccag atataacaaa accggcagga 9841 gcaggggatg taccacaagc aaactataaa atgataggtg ctctaggagt taagaaaaaa 9901 catatagaaa agaaagaatt aaaagatttt atacaaaatc atggtatgtc aggttgggca 9961 ccaacgcaag gacatattcc gtctggagtc ccttatatag gttttgctag aaatgattta 10021 acagaaggta atttaaatag ggttatggta gtaggaaaag gtagtttatt cctaggacgt 10081 atgacaaatt tatttgatgg ggtatctata attatagaaa gaaatacagg atataaagaa 10141 gaggaaaaag gaatttctga ggataaagtg agaaaaataa ttgcagaatc cataaaaaaa 10201 ttagcatcac agctagtaga agaataaggg gtgatgtata gtatggataa taaagaagtg 10261 aataaaataa taggaaaaac tcttcttgat attgcagaat ctatagaaaa gggagacttt 10321 agtagaaaga tagtagtagg aattactact ttaggtagtg aacatggagt tgaaaattta 10381 gtaaaaggtg ctgaagtggc tgctaaaaaa cataatgaca taaaggtagt tttaatagga 10441 cctaaagtgg atacagaatt agaaatagta gaagctaatg aagaagataa aatgtataac 10501 aaaatggaag aattattaga tacaaaatat atagatgcag cagttactat gcattacaat 10561 tttcctatag gggtatcaac tgtaggaaag gtagttaccc cagctgatgg gaaagagatg 10621 tttttagcta caactacagg aacagcttct atgaatagaa cagaagctat gattaaaaat 10681 gcagtatatg gaataataac agctaaaact atggggataa aagagcctaa tgtagggatt 10741 ttaaatttag atggagcaag acaagtagag aaagcattaa aagaattaga taaaaatggt 10801 tataaaataa attttgctaa ttctctaaga gcagatggtg gttcagtaat gagaggaaat 10861 gatcttttaa aaggaacacc ggatgttatg gtgacagata ctcttacagg aaatctttta 10921 atgaaagtat tttcttctta tactactgga ggaagttatg aaggatttgg ctatggctac 10981 ggaccaggta taggagagga ttatgaaaga aatatcctaa ttctatctag ggcttcaggt 11041 gtaccagtgg tagctaatgc tatagaatat gcaaaggatc tagttaaagg taatataaat 11101 aaattaataa aagaagagtt taaaaaggct aatgaggcta aattaaagga tatattaagc 11161 tctatagaaa acaaagaaga caaaaaaata aaagatgaag aagaagttcc aatgcctaca 11221 aaggaaatag ctacagcatc tattagtggg atagatgtaa tggatataga ggatgctcaa 11281 aaaacccttt ggaaagaagg tatatatgca gagggcggta tgggatgcac aggtcctgtc 11341 ataaaagtaa atgataaaaa ttacgataag gctgcagaaa tattaactga aaaaggtttt 11401 atagcttaaa aataaactat aaatatattt gtgaaaatta aagtgaataa gtttatttat 11461 aaaattttaa aggtgaatat ggtattaaaa taaaaaagtc catttacata gtttaagtaa 11521 agtatatttt taaaaagaaa ttttacttaa actagtagtg gacttttttt atattattta 11581 aaagtattag tatataaatt aaatttaatt tggacatatg cagaaatact aaagattatt 11641 catatattta ttaggtatat tttcttatat ttactatatt aaaattaaat ctattttaca 11701 cagatatttt atataaaagt ttgttttaaa agttagtata aagttaataa ccatgataat 11761 ataaaaatat atgattaaaa tataaatata tgaagaaaaa tattattaaa atgttgagtc 11821 ctaggaggaa taaaattgag attaacaaga gatttttatg ctaaggatgc tagagtatta 11881 gcaaaagaat tattagggaa agtattagtt agagaagtag atggtattaa attgaagggg 11941 aaaatagtag agacagaagc ttatattggg gctatagata aagcttctca tgcctatggt 12001 ggaagaagaa ctaaaagaac agaacctctt tatgggaaac cgggtatagc ctatgtatat 12061 tttatatatg gtaagtattt ttgttttaat atcataagta aaacagaagg agaggcagaa 12121 ggggtcctta taagagctct agaaccttta gaaaatataa atcttatatc aaaattaagg 12181 tttaataagg aatttgaaga attaaataat tatcaaagga aaaatataac ttcaggacct 12241 tcaaagcttt gtatggcttt taatattaac agagataata actgggaaga tttatgtgaa 12301 agttctagct tgtatgtgga ggatgttttt tataatgatt ttgaaattat tgaaacagta 12361 agagtaggaa tagattatgc agaggaagct agagattttt tatggagata ttatataaaa 12421 gataatgctt ttgtttctgt aaagtaacaa gtactttaaa atataaatat ttaaataaaa 12481 tagctttgta taagtgatat gggggatgaa atatgggggg aagttataat ttatataaaa 12541 taaaagacat atcttgcata agcaaatatt gtaattgttt gcaattggta tttgaggact 12601 tatacgatct gaaaaaatat tttaatgaaa ataaaacttt attttgtaat aaagctttat 12661 atgtgcttat taataaaata ataatttcaa agatatttat ggagaaaaat aatataacag 12721 gtgaattggc taaaaaaaat ataaaatatt atgcattaac tttagatact ataaatcttg 12781 taaatttggt atttgataat gttgataaga gatttttaga atctatcttt aaagataata 12841 taaaatatga gtatataaat cctagttatt atagtttaga taaggaagat tttttgcatt 12901 atgaggataa tatattctat agatacaata tatttttaaa taaaattata gatgaaataa 12961 atgggtttga ttttatacat agtagttgtg aaataggaga aatatatgaa aaaataatag 13021 ctaaggaata taaaaaatct atgggaatat tttatacacc agaatatatt attgattaca 13081 tattggagaa tgttttttat gagttttcac cactggaaaa cccttttgtt aaattaatag 13141 atatatccgc aggggcagga tattttatta ttaaagctta tgataagttg aaaaaagttt 13201 ttacagaaaa tatacaaaat ttgcaagaaa aatataaaca aaatatttat actattagaa 13261 aaaaaggaca atctattaaa gtaactggtg aatattattg gcaaaaagaa aacttgcact 13321 atcatataat taataattgt atatatgcag cagatataga tatatacgct atccaaataa 13381 caaccataaa tttactttta aaggatacga agtcttatgt aggcaaggta aacgttgcca 13441 attgtgatag tcttataagg tgggaaaaag attttaatcc tactattaaa tttttagata 13501 ataaatataa atataaaacc tataaaataa aaaataaagg cattgaagaa gctgttaatt 13561 ataaagaaaa agaggtatgt aattggaaaa catactttaa actgtataaa ttttggagaa 13621 aaaaatttga ttatattata ggcaatcctc cgtgggtttc tttatctaga aaaaataaaa 13681 aagcttgttg gaaaaattct ttagagtatt atatcaaaaa ttacggtcag tgtgtacatt 13741 ctcctaattt atttgagtat tttataaaga gagctttaga aaaaacaaag aaagatggat 13801 atttagcctt tgttgtacca ataaatttta gtaggaattc tcaatacata caattaagaa 13861 atgaaatatt gaataaatat gagattaaaa atttattttt taatatagct ttttctggag 13921 ttataacaga tggaatggta tttattttga aaaagaataa aaaatgtttt aatgaaataa 13981 aaattaaagt acaaggaaaa gatgagtata aaatagataa aaatgaactt ttttcctgta 14041 atgagtatgg atttacattt aataataatg attttgatga aaaaataaaa aataaaattt 14101 tagaaaactc tagtttttta tcagaaataa gtgatacatt tacaggattt ataggagact 14161 gtaaaaatat atataaagag aatgtagaca agtcttatat taaaatatat aaaggaaaaa 14221 atataaaaaa atttatatgc tattcctatt tttattatga ttttaaagat gaaaatatta 14281 aaggtggaac aaaagattta aaaaaattaa aatataaagg taaaatatta gttagaaaaa 14341 caggaaatga aattatagca gcttatgatg aagaaggtat tataatagaa cagtcattat 14401 atggaataat taatttaaaa caaaacttta gtcataaata tatattaggt attttaaatt 14461 cccagttaat gagttggtat tacaaaaagt acttaataac aaataaagat tctactccac 14521 aactgaagaa atatagattg aataaaattc ctataaaaaa ttgcaataaa aatgttcaag 14581 aggaagtaga aatattatct gacaaaattt tccaagcttt aaaaaatgaa aatgtgaagg 14641 aaatagacta ttattacaaa atattaaacc aaaaagtgtt cagtatttat ggtattgatg 14701 atataaaaat aataagatat ataattaatg ataagtaaag aaatgtataa atgtatataa 14761 aaataaggtt tttctaatta ctatgaaata tatataaatg aaaaaacgtt aattttgaac 14821 aaagtaatat gttattttgt tcaaaattaa ttttttgtct aataatagtt ttgcagattg 14881 aatttatgta acaatagtgt ttaaaaatga aataaaataa caaaacataa caaaaatagt 14941 gaaaaatatt gacgagtaaa tgtttgcaat ggtatcattt tcatatacct tataaaataa 15001 agttacaaga tacaaacaaa aatatccaaa gattacttaa aataagatct cctcttttat 15061 aaaatacaat ataaggatca gtaatctttg gatgattttt aagtttcatt aaaatataga 15121 ttattatgaa tttaatttaa attaatataa attatttatg ggggggtatc tatatggcag 15181 aatataagcc aatggattgt gagtcaataa taaaatatat taaagagtta aatctagata 15241 tatttgatga aaagatggat ttaactgcaa aagaaattgg agatgggaat ttaaatttag 15301 tttttagagt taaagataat aatacaggga aatccgtaat tattaaacaa gcccttcctt 15361 atttaagagt agctggagaa ggctggaagt taactgtaga tagaaacaga attgaagctg 15421 aagctatgat gaagcaggat aaagcttgcc caaacagtgt gcctaagatt tactatcatg 15481 ataaggatta caacctttat gtagcagaag atttgggaag tatggacata cttagaaatg 15541 ggttaatgaa tatgaaaaaa tatcctaagt tcccagatca aatagggaaa ttcctatcaa 15601 gaaatctatt ttacacttca gacttaggat taggtgcagt agctaagaaa tctttagttt 15661 ctaaatttat aaatccagaa ctatgcgata ttacagaaaa attagtgtta actgatccat 15721 atatgaatgc agaatcaaat gatataaatc ctgaaattat ggatgaagtt aaagatatgt 15781 ggggaagaaa agattttaga ttagaggtta caaaattaaa aaatatattt atgacaaaag 15841 cagaagcact cctacatggt gatcttcata caggatctat atttataaca gaagatgata 15901 tgagagtttt tgatacagaa ttcgcttttt atggtcccta tggatatgat ataggacttt 15961 tgtttgcaaa ctttatttta aactatatct cttgggaggg cagagaagat agatcaaagg 16021 aagagataaa agagtttaga aaatatttat tagataccat agaagaaatt tggcatgaat 16081 ttgaaatagg tttaaaagaa atttgggaca aagattgtaa agaaatatct tcaactgttg 16141 aaggatataa agaatattat ataaataact tgcttcaaga aactataggt tttagtgctt 16201 gtgaagttat gagaagaata attggaatgg ctcatgtacc agatttagat gttttaaaag 16261 atttaaagca aaaggctaaa gctcaaagat tgggactaaa aataggacaa gaaatggtaa 16321 tgagaagaaa taaaataaca aaaatagagg atttgtcagt atttatttca caaataacaa 16381 aataattttt aagatactta tttggattaa aagtatatag agtacttaaa aacaactgtt 16441 ttatataata agattttcaa ataaaaaagg attagtaaag aagaaataag gtaaataaga 16501 taaaagtaaa gaggaggatt aaaaatggca gagttattag ctataaaatg ggatgataat 16561 agagataagt taatactttt agaccaaaca atattaccaa ataaaattga atatatagaa 16621 tacgatactg cagaaggtgt atacgattcc ataaaggata tgatagttag aggagctccg 16681 gctataggag ttacagcagc ttatggtcta tattttgcag caaaagtagc accagaagat 16741 aaatttgaga acttctttaa atatctaaaa gaaaaatcat catatttaga ctcaagtaga 16801 ccaacagctg taaatttatc ttgggcctta aaggttatgg aaagtaaagc tttagaaaat 16861 aaagataaag atgttaaaga aataaagagt atattaagag aagaagcaaa aagaattcat 16921 gaagaagata tagaaatatg caaaactata ggggaaaatc ttataacttt attaaaggat 16981 ggagtgggaa tattaactca ttgtaatgct ggacaacttg ctacatctaa atacggaaca 17041 gctacatctc ctatgtatct tgcaaaggaa aagggctgga attttaaagt ctattcagat 17101 gaaactagac caaggcttca aggatccact ttaacggctt tagagttata tgaagcagga 17161 atagatgtaa ctactataac agataatatg gcagctatgg ttatgtctca aggtaaaatt 17221 gatgcggtaa tagtaggatg cgatagaata gcagctaatg gagatactgc taataaaata 17281 ggaaccatgg gagtttcaat tttggctaaa tattttggaa taccaatgta tattgctgca 17341 ccaactccaa gtatagatat aaatacaaaa acaggagaag atataccaat agaagaaaga 17401 aatccagaag aagttactag tagatttggt gtttggacag ccccaaaagg tgtaaaagtt 17461 tataatccag gatttgatgt tacaccacat gaaaacataa ctgcaattgt tacagaaaag 17521 ggtatagtat atcctccttt taaagaaaat ttaaagaaac tttttgaaaa ataagaggtt 17581 agaaaggggc taaaataatg gtagaacttc ttaatataaa aaatataaaa aagtcctttt 17641 cagatgttca agtattacat gaaataaata atttggggat tttatcccca aatttattaa 17701 tcacttagta aagagggtga caatttgaat aatgaaacgt atttaaggtt acaaattgta 17761 gaggtaggaa aaagacttca acaaagattt tttgtagctt caaatgatgg aaatataagt 17821 gctaaacttg atgaaaatac tatattgatt acgcctacag gggttaataa aggagaagta 17881 accccagatc aaataataaa agtagataga gaaggaaatg ttatagaagg tcatatgaag 17941 gttacatctg aaataaaaat gcatttagct gtttataata tgagagaaga tgtaaaagct 18001 atagttcatg cccatccacc agcatccaca gctttttcag tatcaaaaga aaaactagat 18061 gatcctgtta ttcttccaga agcagttttt tcattaggga aaataggata ttgtgaatat 18121 ggaactcctt ctactgatga ggttccaaaa gctatagaaa aagaaattcc atatagtgat 18181 gtacttttat tatctaacca tggagctctt acagtaggta cagatgtaat gcaggcttat 18241 tacagaatgg aaaatttaga aatggtttca aaggtaacta tttattcaaa aatgatagga 18301 aatataaaaa ctttaaatga actacaagtt gagaaattaa ataaagtaaa agaagaaaaa 18361 ggttgggggt aaattatagt taccacccat agagcttttt aataattagg taaatatgcc 18421 tgtaatagaa ccattatgtt taaattttgt aaaaagtggt gtcatgtaca agttatacta 18481 taacttaatg gtattttgtt ttataattaa ttataaaata aaaatattag gaataggtgg 18541 gaaatatgaa acttaaacct gaaattagaa gagaaaagat attagcagaa atagaaaaaa 18601 ataaaactgt ggatataatg gaattaagtg aaaaattaca ggtatcagaa atgactataa 18661 gaagagactt aaaaagatta gaaagcagtg aaaaattact tagaacctat ggaggagcta 18721 ctcgtatatc tgaaggagaa tgtaaaaagg ttatagatga tcccttaaag ggtagagtat 18781 taaaaaataa agatgaaaag gctattatag gtaaatatgc aggggaatta gtagaaaatg 18841 atgatgttat tatgatagat gctagtacta cagccttagc aatatgtaaa tatataagag 18901 ataaaaaggt aacagtagtt acaaattcta taagtgtagt aacagcctta gcttcttttg 18961 ataatataac ggtggtagta gcctgtggaa tattacgaca tagttcttta tctttagtag 19021 gctcctatgt agaagaatct tttaaaaaat ttaatataaa aaaatctttt atatcagcta 19081 aggccttgtc ctttgaagca ggacttacag atataaatgc ttttgaagta gaaacaaaaa 19141 aggctgctat gtctgtaagt aaagaggtta tagttctttt agatcactct aaacttaata 19201 atatatccct tttaaaggtt tgtgaaacaa aagaaataag taaaataata atagacggac 19261 ttaaggagtt tacagtggaa gaagaagaat tattaaataa atttaaatct aatggtatag 19321 aagtaataat agctaaatga //