LOCUS NC_009495:13 18435 bp DNA linear BCT 08-SEP-2013 DEFINITION Clostridium botulinum A str. ATCC 3502 chromosome, complete genome. ACCESSION NC_009495 SOURCE Clostridium botulinum A str. ATCC 3502 chromosome, complete genome. COMMENT locus start: 2244774; locus end: 2263208 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.442783; n0_4mer:D = 19.315418; n0_4mer:PS = 30.740651 FEATURES Location/Qualifiers source 1..18435 /organism="Clostridium botulinum A str. ATCC 3502 chromosome, complete genome." gene complement(1..1671) /gene="" /locus_tag="" /db_xref="2244774..2246444" CDS complement(1..1671) /gene="" /product="glycosyl hydrolase" /translation="MKKKSLLIGIMNLLILFGIVNIDTKLVYAYTNATAMYVNPVNEK KSDIMTVDWSTTKNAPNTYWAVHNWNAGGEAGGYAGFQQRTDRRTLHFAIWDPVSVRK PIEAEYLSSSSTSSRFGGEGEGMKVETNYDWKPNSWYKMTMRNWQEDGHTKFGQWVRD EPTKEWKQIAVLDFPVANVNFGWGTGMFQEDWAGNGQDVRNARLKNLYSRSVLNKDWN SLYQQKITSQYPDKNWDGGGNSEYVWVEAGGNTKPSMISGQVFTINQPSKPDVGTLDF DITNAKYENNYLNISWKLKNQSTPQFKGKIEIYNNPSMTGTPIKTINNIKSYENSIKE NCQLASSTGLYAKVIITDLFDNTITKTVTLVGSTENNYKGSNFTFDFKGYSDNKFAKL DLNLDKLTSKLTVENIKTHYYFNDSYASILVQDNLGQLVFYKDFIGNEVNDALVKDIP LKEGYYLTVKHREYSNRLFITNKDKNLKLNKAATNSYKITKNELKEVNEDEINKLPEN EWNPSKSYNTGDKVSYKGKTYKAKWWSHGFAPDTKVQNSWETPWELIS" gene complement(2220..2510) /gene="cchA" /locus_tag="cchA" /db_xref="2246993..2247283" CDS complement(2220..2510) /gene="cchA" /product="microcompartments family protein" /translation="MKYDALGMIETKGLVGSIEAADAMVKAANVYLIGKEYVGGGLVT VMVRGDVGAVKAATDAGAAAAQRVGELVSVHVIPRPHSEVEVILPSSKEVAK" gene complement(2584..3234) /gene="" /locus_tag="" /db_xref="2247357..2248007" CDS complement(2584..3234) /gene="" /product="propanediol utilization protein PduL-like protein" /translation="MDNCEEVLKLLLEVVKGKELNNAVNRNSSEIPVGISNRHIHLSQ KDLDSLFGENYGLTKIKDLSQPGQYACKEVVTICGPKGAIEKIRILGPVRSKTQVEVL AGDCIKLGAVSHVKLSGDLNRTSPITIVGPKGSVQLEEGLIVAQRHIHMTPEDAKNLG VHDGEIVSIKFEDLRGGIYNNVAVRANDASSLECHLDIEEANAMGINSKSKVTIVK" gene complement(3234..4832) /gene="eutE" /locus_tag="eutE" /db_xref="2248007..2249605" CDS complement(3234..4832) /gene="eutE" /product="acetaldehyde dehydrogenase" /translation="MENFDKDLRSIQQARDLARLGKVAADKIADYTEEQIDKILRNMV RVAEENAVCLAQMAVEETGFGKVEDKTFKNHLAATILYNSIKDMKTIGVINEDKENKL IELAEPVGLVMGIVPSTNPTSTAIFKAMISIKSRNAIVFAPHPAAAKCTIKAVELMRD AAIEAGAPENIISAVTIPTIGATNELMKSKEVAIIIATGGPGMVKAAYSSGTPAIGVG AGNSPAYIERTANVEKAVKNIIASKTFDNGTICASEQSIICEECNHDLVVAEFKKQGG YFMTEEETEKVCKLLFKKGNAMNAKFVGRSPQVIASAAGFTIPAGTKVLIGRQNGVGE GYPLSFEKLTTVLGFYTVKDWHEACELSIKLLQNGIGHTISIHTEDRDMVMKFARKPA SRILVNTGGTQGGTGASTGLNPSFTLGCGTWGGSSVSENVTPKHLMNIKRVAYGIKDC TNLASNDPTFNCIKTAENCHGVQNQFMNMSPAQIAAAAEVLNKANNCAENTNTCTECS NENTKNEELLDLVNQIVAAMKGAN" gene complement(4867..5664) /gene="" /locus_tag="" /db_xref="2249640..2250437" CDS complement(4867..5664) /gene="" /product="propanediol/ethanolamine utilization protein" /translation="MQALGLIETKGLLAAVEAADTMVKSADVSIIEKTYVGGGLVTIS VTGDVGAVKASIEAGVAAVKKLDEGFLVSEHVIPRPHEELESIIGPNTPPEDPSSNDN TENVEDADDTEAVEKAEDTEKVENTKAVDSVEDTESVEVTKDIVDAKNVENTKKAETV KDVKAVDNTEHVDTKNNIKENQHGLDGDLDKLHKLNLENLHKEDVDNLIRQNGIEKTI LILAKLKVVKLRNLAREYKDLGIAGRTISKAGKNLLINKFKLYYEKN" gene complement(5685..6347) /gene="eutQ" /locus_tag="eutQ" /db_xref="2250458..2251120" CDS complement(5685..6347) /gene="eutQ" /product="ethanolamine utilization protein EutQ-like protein" /translation="MKKLIAAKDIEALILKGEKVLYVDGTEIITPSAKDLVKNNGIVI TTEAPAPKVEHLIGKNVPSIEGIDSEMMLKFLRAMMDKGLLQEMLQCLKGKDLPFKAE CDPNGLKVVRGNTVKMDVFDTGNPNAKVQFQELVSKEESKMSAGFLIIEDSKFDWELT YEEIDYVIEGTLTVEINGKTYTAYPGDVLFVPSGSKVVWRSPDKARVFYTTYPANWAD LL" gene complement(6546..6809) /gene="eutN" /locus_tag="eutN" /db_xref="2251319..2251582" CDS complement(6546..6809) /gene="eutN" /product="polyhedral organelle formation protein" /translation="MIAARLIDNVWATRKAESLSGLKFMLAEEIGGIDEGRRFIVVDI ISAGIGDRVIVSTGSSARRMLGDDNIPVDAVVIGIIDEDCNFG" gene complement(6806..7108) /gene="" /locus_tag="" /db_xref="2251579..2251881" CDS complement(6806..7108) /gene="" /product="hypothetical protein" /translation="VDFRIIKSPSSSTKDILRRRMGGNCKTDLESADAIGLVQGKLID MIYAADIAEKAVGVTVEDIRGTCPQHMVLLGIFGDTSSVEAALNEIKLKMKEVKAI" gene complement(7186..8031) /gene="eutJ" /locus_tag="eutJ" /db_xref="2251959..2252804" CDS complement(7186..8031) /gene="eutJ" /product="ethanolamine utilization protein EutJ family protein" /translation="MSEEKLTFEYCDNMVRKFEEVIEKPIVNGSSVYYTGVDLGTACV VLAVLDENYNPVAGAYRYADVVRDGMVVDYIGAVRIVRELKEEIEEKLNTELIYAAAA IPPGTDALDSGAIKNVVQSAGFELTCLLDEPTAANAVLKIQNGAVVDIGGGTTGISIL KDGKVVYVVDEPTGGTHFSLVISGAYEMPFNKADEYKRDNKNHKEILPVLKPVVEKVS SIINNHIKNYDVNEISLVGGTCCLTGIEEIIEKQTGVYTHKPKNPMFVTPLGIALSCT QDIIE" gene complement(8013..8741) /gene="eutT" /locus_tag="eutT" /db_xref="2252786..2253514" CDS complement(8013..8741) /gene="eutT" /product="hypothetical protein" /translation="MMKFITEEYLRDLYRKEPFNTYKLEQGQRLTPGAAEYLSDKGIE LSDDSKVNKSSKVNANISPKNSAKTPEETSKETIKDVGNSDVKFNLNKKLCLKLKSME AKFLVVSSEILKEDIILAQNIINLGRKISNIRNVLDGKGTLEPIYLKECTGMNSSNSE ADLDDCFEITEFHMQLPKSNAILKMNVLRCAVQELQFEIIDTYKSDDESLKSKIMDNV NLIINSLSQLICLAVGGKECQRKN" gene complement(8748..9176) /gene="eutP" /locus_tag="eutP" /db_xref="2253521..2253949" CDS complement(8748..9176) /gene="eutP" /product="GTP-binding protein, EutP/PduV family" /translation="MVIGPSKCGKTTLVNALNDYDGPLRRTPDLIYGKNTIDVPGSYI ENAWMYKHIIAAAQDASCVLILVDQSNCTEIYSHGFAKSFRCPVIGVITKCDLMPKNK EKCEMQLKKIGVSEPYFHISFEMGTGIDALKKYLFEKGEE" gene complement(9191..9544) /gene="eutS" /locus_tag="eutS" /db_xref="2253964..2254317" CDS complement(9191..9544) /gene="eutS" /product="ethanolamine utilization protein EutS-like protein" /translation="MGDFSDRNIQRVIQESVPGKQITIAHVIASPMPDIYDRLGIDEK GAIGILTLSPFETAIIAADIATKASDVEIGFLDRFTGSVVISGDVQSVETALSAVNDT LKDMLGFTTAPITRT" gene complement(9584..10546) /gene="" /locus_tag="" /db_xref="2254357..2255319" CDS complement(9584..10546) /gene="" /product="glycyl-radical activating family protein" /translation="MSNMSNGNLGIIERKARIFNIQKYNMYDGDGIRTLVFFQGCPLR CKWCANPEGLEKKYRVMLKSNLCVNCGACVSACPVGIHTISNKTLKHEVNRDIDCIGC GKCKEACLKSAISIVGEEKTISELLKIVEEDRTFYEMSGGGVTLGGGEVLMQPEAATS LLMACKQEGINTAIETCGYTNLETILKVAEFVDLFLFDIKNINSDRHHELTGVRNERI LENLQELLKKKYNVKIRMPLLKGINDSQDEIEKTMEFLLPYKDYKNFKGIDLLPYHKM GVNKYNQLGMEYPIKDDPSLKSEDLDRIEGWIKKYDLPVKVIRH" gene complement(10701..13241) /gene="" /locus_tag="" /db_xref="2255474..2258014" CDS complement(10701..13241) /gene="" /product="formate acetyltransferase" /translation="LDIREFSNKFMEATKNMSDEERAGLMKMFQSVSNEITKEEPATS KVACDNNGEIPDGMTERLVKLKETYLKHVPTITTHRARAITKIAKENPGTPKSVLRGK CFKHCCETAPLVIQDNELIVGAPNGQPRAGAFSPDIAWRWMVDEIDTIGTRPQDPFYI SEEDKKIMREELFPYWAGKSVDEYCEDQYREAGVWELSGESFVSDCSYHAVNGGGDSN PGYDVVLMKKGMLDIKREAEEKLAELKYENPEDIDKIYFYKSLIDTAEGVMIYAKRMS DYAAELAQKETNPKRKAELQKISEINARVPAHKPSTYWEAIQAVWTIESLLVVEENQT GMSIGRVDQYMYPFYKADIEAGRMTDYEAFELSGCMLIKMSEMMWITSEGGSKFFAGY QPFVNMCVGGVTREGRDATNELTYLLMDAVRHVKIYQPSLACRIHKSSPQKYLKKIVD VIRAGMGFPACHFDDVHIKIMLAKGVSIEDARDYCLMGCVEPQKSGRLYQWTSTGYTQ WPICIELVLNNGVPLWYGKQVCPDMGDLSQFKTYEQFEAAVKEQIKFITKWTSVATVI SQRVHKELAPKPLMSMMYEGCMENGRGVEAGGAMYNFGPGVVWSGLATYADSMAAIKK LVFEDKKYTLQEMNEALKADFVGYEQLRKDCLEAPKYGNDDDYADLIAADLINFTEQE HRKYKTLYSVLSHGTLSISNNTPFGQMTGATANGRRAWMPLSDGISPSQGADFKGPTS IIKSVSKMSCEDMNIGMVHNFKLIAGLLDTPEGEQGIITLLRSACALQLGEVQFNYLD NKTLIEAQKHPDQYRDLIVRVAGYSAFFVELCKDVQDEIISRTMLTHF" gene complement(13291..14784) /gene="" /locus_tag="" /db_xref="2258064..2259557" CDS complement(13291..14784) /gene="" /product="aldehyde dehydrogenase" /translation="MNIIDNDLLSMQEARILVENAREAQKKLATFPQEKLDEIVERMA EEVEKHLKELAKISNEETEYGKWQDKYVKNHFVCEYLKNKLKGMRCVGIINEDKINKT MDVGVPMGVVIAFPPATSPVSTTIYKALIAIKSGNAIIFSPHKRAKNTISKTVDILIR AAEGVGLPEGALAYLHTVTESGSLELMKHKDTSLIMNTGVIEMLDEAYKSGKPVIYGG NGNGPAFIERTADIEKAVKDIITSKNFDYGVVSAAEQSIVVDSLIASEVKQELIKNGG YFMTEEEALKLGKILFNQNGSPDLEMIGKSPQFLAKKAGFQVSEGVKVLISNEKFVSK NNPYSREKLCPVLAFYIEDDWMHACEKCIELLLTERYGHTLVIHSKDEEVIRQFALKK PVGRVLVNTAGTFGSMGATTNLFPSMTLGSGSAGQGMTSDNVSPMNLLYIRKVGYGVR MVDEIVKTVNDKEDSIPAVLNGKLNGNEIDNYKLLESILKKVLQDLK" gene complement(14822..15130) /gene="pduA1" /locus_tag="pduA1" /db_xref="2259595..2259903" CDS complement(14822..15130) /gene="pduA1" /product="microcompartments family protein" /translation="MARYEALGLIETFGLVFALEAADAMCKSADVELIGYENVASGYI SVLVRGDVGACKTAVDAGVAAVNGMEGGNLYSSIVIPRPHEDLEKIIKRYAITDIITE" gene complement(15154..15450) /gene="pduA2" /locus_tag="pduA2" /db_xref="2259927..2260223" CDS complement(15154..15450) /gene="pduA2" /product="microcompartments family protein" /translation="MRYYGDEALGLVETIGLVPALEAADKMLKAANVELISYENIGST LVTIMVKGDVGAVKSAVEAGAEAARAIGKLTAHNVMPRPIREVGDIVSVHDIDS" gene complement(15523..15675) /gene="" /locus_tag="" /db_xref="2260296..2260448" CDS complement(15523..15675) /gene="" /product="hypothetical protein" /translation="MLKVKIALKYVIYNKLSKDSYYKKYIDFPPKGKGYNQHIATKKC MKTYTE" gene complement(15754..16020) /gene="" /locus_tag="" /db_xref="2260527..2260793" CDS complement(15754..16020) /gene="" /product="hypothetical protein" /translation="MKPLNYAILKHFTKVSEACADDVIKALKGQYGNFKALNKKAVIN ALLTAEANGLIEETRFDLDNNNELRVYYHAHAEGAETINKYIPD" gene complement(16007..17119) /gene="" /locus_tag="" /db_xref="2260780..2261892" CDS complement(16007..17119) /gene="" /product="hypothetical protein" /translation="MNGDSKAVSLEAVAAKKKLSSDFFKKGISLALFSGLAYGLYTAF LTMGMTKGVWGDWYGPNTAGLSAFAIAYLLAALGNAINDTCSAIWSLLYAGVKGKFGD FLRCVNTKPGRIMILAALIGGPIAGTAYVIALQMAGSIVVPISALCPAIAAILGKILY KQELNKRMAFGILICVCASFLIGSTGLSGGASANTLIGIAIAIIAALGWGFEGCVAGY GTAMIDPEIGICIRQVTSGIANLFILVPIFGMMAGGIGISTDLAIKAFTSSPAMVWFV LSGLLSFVTFMTWYAGNSMCGAGLGTACNGTYSFFGPLFCLLVLGVYGGMDGWSLPPV AWIGAVIMMFGILTISMNPLDLFKGKKMEVDIDETA" gene complement(17605..18435) /gene="" /locus_tag="" /db_xref="2262378..2263208" CDS complement(17605..18435) /gene="" /product="MerR family transcriptional regulator" /translation="MEDELYSIGKVGKICKITKKALRYYDKMDILSPDKVADESGYRY YSKNTLLSVPVIKYYKQSGFKLEEMKVFLEGKTYDFFHTSFRNKIDELKELEKEINLK LRSVKDWDDLIVEAQMVIENNVSDVAIKYIDNRTLTFLDQDFEYDYMDSIINIEFTNY IDSIENAITGPVIIRFPCFQDKMNGKCNKMTIMQETILKCREELSVEFGGWMVAACYH IGPHETINETYKKIKDWTQKHGYICSEESYERYVTDYWTTKNRDRFVTEVLIKISREK" ORIGIN 1 ctaacttatt agttcccaag gtgtctccca tgaattttgt acttttgtat ctggagcaaa 61 gccgtgtgac caccattttg ctttataagt ctttccttta tagctaacct tatctcctgt 121 gttatagctt ttactagggt tccattcatt ttcaggtaat ttattaattt catcttcatt 181 aacttctttt aattcatttt tagtaatttt atatgaatta gtagcagctt tattaagttt 241 taaattttta tccttattag ttataaaaag tctattagaa tactctctat gtttaactgt 301 tagataatat ccttctttta aaggaatgtc ttttactaaa gcatcattta cttcattgcc 361 gataaaatct ttatagaaaa caagttgtcc taaattatct tgaactaaaa ttgatgcata 421 gctgtcatta aaataataat gagtttttat attttcaaca gtaagtttac tagttaattt 481 atcaagattt aaatcaagct tagcaaactt attatcacta tatcctttaa aatcaaaagt 541 aaagtttgat cctttataat tattttcagt gctaccaact aaagtaactg tcttggtaat 601 ggtattatca aataaatcag ttataattac ttttgcataa agaccagttg aactagccaa 661 ttgacaattt tcttttatcg aattttcata tgatttaata ttatttatag ttttaattgg 721 agtaccagtc atactaggat tattgtaaat ttctatttta cctttaaact gaggagtact 781 ttgatttttt aatttccaag aaatatttaa atagttattt tcatatttag catttgttat 841 atcaaaatct aaagttccaa catctggttt gctaggttga tttatagtaa atacttgtcc 901 actaatcatt gatggttttg tattaccacc ggcctcaacc caaacatatt cagaatttcc 961 tcctccatcc caattcttat caggatattg agaggtaatt ttttgttgat ataaagaatt 1021 ccaatcttta tttaaaacac ttctactata tagatttttt aatctagcat ttcttacatc 1081 ttgaccattt cctgcccaat cttcttggaa cattcctgtt ccccaaccaa agtttacatt 1141 agctacaggg aaatctaata cagctatttg cttccattct tttgtaggct catctcttac 1201 ccattgtcca aatttagtat gtccatcttc ttgccaatta cgcatggtca ttttatacca 1261 actattaggt ttccaatcat aattagtttc tactttcatt ccttctcctt ctccaccaaa 1321 tcgtgatgaa gtagaacttg atgatagata ttctgcttca atgggctttc ttacagagac 1381 tgggtcccaa attgcaaagt gcagtgtacg tctgtcagtt ctttgttgaa agccagcata 1441 tcctccagct tctccaccag cattccaatt atggacagcc caataagtat taggtgcatt 1501 tttagttgtg ctccaatcta ctgtcattat atcagatttc ttttcattta cagggtttac 1561 atacatagca gttgcattag tatatgcata aactaatttg gtatctatat taacaatacc 1621 aaataatatt aacagattca taattccaat taacaaggat ttcttcttca ttaattatct 1681 tcctttcctt ggttaaaatt tttaataatt tcaaaaatat attagtttaa agtaactaat 1741 agtctattat ttatatttgg ttcacagctt tatattgatg caaaaccccc ccttttttac 1801 tataattaag tctgttaaat tatataaatt ttaaaatata acaataaata tagaatatat 1861 tttttaatac ttattaacag acataaattg tatattaaaa ttcatttata tattaataac 1921 aaaaaatgaa ttttcaacca tatgtatatt atatttttcg aattaaaatt ataaagttta 1981 atataaaatt aaatataaat ataagattta taaataaaat atactatttt ataataatga 2041 actaaaatat gtaagtaaaa gtgtggaaaa tacttgtaat aggtgttaat tagagcttac 2101 catagatatg tttattttta actaaaatgg tatgaatggt tattgtgata gaataaatgg 2161 agttatttaa ataaaaacgc cgctaaatta tctttagcgg cgttttctta ttttaaatct 2221 tattttgcaa cttctttaga tgatggaaga attacttcaa cttcagagtg tggacgtggt 2281 ataacgtgaa ctgatactaa ttctccaaca cgttgtgcag ctgcagcacc agcgtctgta 2341 gcagctttaa cagctccaac atcacctcta accataacag ttacaagtcc gcctccaaca 2401 tattctttac ctattaaata tacgtttgct gctttaacca tagcatctgc tgcttctatt 2461 gatcctacta atccttttgt ttctatcatt cctaatgcat catatttcat tttaaaatcc 2521 tcctaaaata tcttttttta tttatttaaa tttttaatta taagcaatta tttatttaat 2581 tttttatttt actattgtta cttttgactt tgaattaata cccattgcgt tagcttcttc 2641 aatatcaaga tgacattcaa ggcttgaagc gtcattagct ctaacagcta cattgttgta 2701 tattccgcct cttaaatctt caaattttat tgacactatt tctccatcat gtactcctaa 2761 atttttagca tcttcaggtg tcatgtgaat gtgtctttgg gcaactatta atccttcttc 2821 tagttgaaca gaaccctttg gtccaactat tgtaatagga gatgttctat ttaaatctcc 2881 agataatttt acatgggata ctgctccaag cttaatgcag tctcctgcta atacttcaac 2941 ctgagtcttg cttcttacag gacctaagat tctaattttt tcaattgcac cctttggtcc 3001 acaaattgtt acaacttctt tgcaagcata ttgtccaggt tgagataaat cttttatctt 3061 agtaagccca taattttcac caaaaagact atctaaatcc ttttgtgaaa gatgtatatg 3121 tctattagaa atccctactg gaatctcaga tgaatttcta ttaactgcat tatttaattc 3181 tttaccttta acaacttcta gtaaaagttt taatacttct tcacaattat ccattagttt 3241 gcccccttca tagcggcaac tatttgatta actaaatcta aaagttcttc attttttgta 3301 ttttcattac tgcattcagt gcaagtatta gtgttttcag cgcaattatt agccttattt 3361 aaaacttctg cagctgctgc aatttgtgct gggctcatat tcataaattg attttgaact 3421 ccatgacagt tttcagcagt ttttatgcag ttaaaagttg ggtcattaga tgctaaattt 3481 gtgcaatctt ttataccata agcaactctt ttaatgttca taaggtgctt tggagtaaca 3541 ttttcagata ctgagcttcc tccccaagta ccgcatccta aagtaaatga aggattaaga 3601 cctgtacttg cacctgttcc accttgagtt ccaccagtgt taacaaggat acgggaagct 3661 ggttttctag caaacttcat aaccatgtct ctatcttctg tatggatgct aattgtgtga 3721 ccaattccat tttgaagtaa tttaatactt aattcacatg cttcatgcca atcttttact 3781 gtatagaatc caagaactgt tgtaagtttt tcaaaagata atgggtaacc ttctcctact 3841 ccattttgtc ttcctataag tactttagtt cctgctggaa ttgtgaatcc tgcagcactt 3901 gctataactt gtggacttct tccaacaaat ttagcattca tagcattacc ttttttgaat 3961 aatagtttac aaactttttc agtttcttct tctgtcatga agtatccacc ttgtttttta 4021 aattctgcaa caactaggtc atgattacat tcttcacaga ttattgattg ttctgatgca 4081 cagattgtac cattatcaaa agttttactt gcaataatgt ttttaacagc tttttctaca 4141 ttagcagttc tttcaatgta tgctggagag tttcctgcac caacaccaat agctggtgtt 4201 cctgagctat aagcagcttt aaccattcct ggaccacctg tagctattat tatagctact 4261 tctttgcttt tcattaattc atttgtagct ccaattgttg gaatagttac agcacttata 4321 atgttttctg gtgctccagc ttctattgct gcatccctca ttaattcaac tgctttaatt 4381 gtacattttg cagcagctgg atgtggtgcg aacactatag cattacgaga tttgattgaa 4441 atcatagctt tgaaaattgc ggtagaagtt gggtttgttg aaggtactat acccataact 4501 aagccaactg gttcagcaag ttctataagc ttattttcct tatcttcatt aattacacct 4561 atagttttca tatctttaat tgaattataa agtatagtag ctgctaagtg gtttttgaaa 4621 gttttatctt caactttacc aaagcctgtc tcttcaactg ccatttgtgc taaacaaaca 4681 gcgttttctt ctgcaactct taccatatta cgtaaaattt tgtcaatttg ctcttcagta 4741 taatcagcaa ttttatcagc tgctactttt ccaagtctag caagatctct cgcttgttgt 4801 attgaacgca aatccttatc aaagttttcc attattcctt acttcctttc gtaaccttta 4861 aaatagctaa tttttctcgt aatataattt aaatttgtta attaataaat ttttacctgc 4921 ttttgaaatt gttctacctg caattccaag atccttatat tcacgagcta gatttctaag 4981 cttaacaact tttagcttag ctaatattaa aatggttttt tctataccat tttgtcttat 5041 taaattgtct acatcttctt tgtgtagatt ttctaaattt aacttatgta gtttatctaa 5101 atccccatct aatccatgtt gattttcttt aatattattc ttagtatcta catgttctgt 5161 gttatctaca gcttttacat cttttacagt ttcagctttt tttgtatttt ctacattctt 5221 tgcatctact atatcttttg taacttctac ggattctgta tcttctacac tgtctacagc 5281 ttttgtattt tctacctttt ctgtatcctc tgctttttct acagcctctg tatcatctgc 5341 atcttccaca ttttctgtat tatcattaga tgatggatct tctggtggag tattaggtcc 5401 tattatgctt tccagttcct catggggacg tggaattaca tgttctgaaa ctaaaaatcc 5461 ttcatcaagt ttttttacag ctgctactcc agcttctata gatgctttta ctgcacctac 5521 atcccctgta actgaaattg taacaaggcc gccacctaca taagtttttt cgataatact 5581 tacatctgct gatttcacca ttgtatcagc tgcttcaaca gctgcaagta atccctttgt 5641 ttctattaaa ccaagcgctt gcataggtaa atcctcctaa tcttctataa aagatccgcc 5701 caatttgctg gatatgttgt ataaaatacc ctagctttat ctggggatct ccaaaccact 5761 ttagaacctg atggtacaaa caatacatct ccaggataag ctgtatatgt ctttccatta 5821 atttcaacgg ttaaagttcc ctcaataaca taatcaatct cttcgtaagt taattcccaa 5881 tcaaattttg aatcttcaat aattaaaaat cctgcactca tttttgattc ttctttactt 5941 accaattctt gaaattgaac ctttgcattt ggattaccag tatcgaatac atccattttc 6001 actgtgtttc ctctaacaac tttaagtcca ttaggatcac actcagcttt aaatggaaga 6061 tcctttcctt ttaaacattg aagcatttct tgtagaaggc ccttgtccat cattgctcta 6121 aggaatttaa gcatcatttc actatcaatg ccctctatac ttggaacatt tttacctatt 6181 aaatgctcta ctttaggtgc aggagcttct gtagtaatca ctattccatt attttttaca 6241 agatccttag ctgatggtgt tattatttca gtaccatcta cataaagtac tttttcaccc 6301 tttaatatta gggcttcaat gtcttttgca gcgattaatt ttttcatgtt ctcacatcct 6361 ttcaaacttt caaataatat caaaatctct atataaaact ccttctccta ttatggagtg 6421 agtaagctag catatcaaaa tcaacactct ttgtaaatga tcacttcaaa attgtagatt 6481 ttgcatgctt atttaagatt ttgcatgtgt tttaaatatt atgtttattt taagaaagtt 6541 gtgttctaac caaaattgca atcctcatca attattccaa taacaactgc atctacagga 6601 atattatcat cacctaacat tctgcgagca gatgatccag tactaacaat aactctgtca 6661 ccaatacctg cactgataat atcaacaaca ataaatctgc gtccttcatc tatcccacca 6721 atttcctcag caagcataaa tttaagtccg ctaagggatt ctgcttttct agtggcccat 6781 acattatcaa taagtcttgc tgctatcata ttgcttttac ctctttcatt tttaatttaa 6841 tctcatttaa tgcggcttca actgatgatg tgtcaccaaa aataccaagt aaaaccatgt 6901 gctgaggaca tgtacctcta atatcttcaa cggtaactcc aacagctttc tcagcaatat 6961 ctgcggcata aatcatatcg ataagtttac cttggacaag tcctattgca tcagcacttt 7021 ctaaatccgt tttacaattt ccacccattc gtcttctaag aatatcttta gtgctactag 7081 aaggtgattt tataattcta aaatccactt ttaaacactc tccttattag gcacatgaaa 7141 ataaataaca agtcaaagat ggcagtatat ttattttcat gtgtcttatt ctataatatc 7201 ttgtgtacag cttaatgcta ttccaagtgg tgtaacgaac ataggatttt taggcttgtg 7261 agtatatact cctgtctgct tttcaataat ttcttcaatt cctgttaaac aacaagtacc 7321 acctactaaa gaaatttcat taacatcata atttttaata tgattattaa taattgatga 7381 caccttttca accactggtt ttagtactgg taaaatttcc ttgtgatttt tattatctct 7441 tttgtattca tctgctttat taaaaggcat ttcatatgca cctgaaataa ctaatgaaaa 7501 atgagtacca cctgtaggtt catcaacaac ataaacaact tttccatctt ttaaaattga 7561 tattccagtt gttccaccac cgatatctac aaccgcacca ttttgaattt taagtacagc 7621 attagcagca gtaggttcat ctaaaagaca tgtcaattca aatcctgctg attgaactac 7681 atttttaatt gctccagaat ctaaggcatc cgttccaggt ggaattgcag cagcagcata 7741 aataagttct gtatttagtt tttcttcaat ttcttcttta agttctctca caatccttac 7801 tgctccaata tagtcaacaa ccataccgtc acgaactaca tcagcatatc tatatgcacc 7861 cgccactggg ttgtagtttt catctaaaac agctaatacc acacaggcag tacctaggtc 7921 cacacctgtg taataaacag aagacccatt aacaattggt ttttctataa cttcttcaaa 7981 ctttcgaacc atattatcac aatattcaaa agttaatttt tcctctgaca ttcttttcct 8041 cctactgcta aacaaattaa ttgggacagt gaattaatta ttaaattaac attgtccata 8101 attttgcttt ttaaactttc atcatcactt ttatatgtat caattatttc aaactgtaat 8161 tcctgcaccg cacaacgaag tacgttcatt tttaaaattg cattgctttt tggaagctgc 8221 atatgaaatt ctgttatttc aaaacaatca tcaagatccg cttcagaatt tgatgaattc 8281 atcccggtac attcttttaa ataaataggt tcaagggtac cttttccatc taaaacattt 8341 ctaatgtttg atattttcct acctaaattt ataatattct gtgctaaaat aatatcttct 8401 tttaatattt cactactaac aacaagaaat ttagcctcca tggatttcaa ttttaagcaa 8461 agcttcttat tcaaattgaa tttcacatca ctatttccca catcttttat tgtttcttta 8521 gatgtttctt ccggtgtttt tgctgagttt tttggggaaa tattcgcatt cacttttgaa 8581 gacttattta cttttgaatc atcactcaat tctattcctt tatcagataa atactcagct 8641 gctccagggg taaggcgctg tccttgttct aacttgtagg tattaaaagg ttcttttcta 8701 tataaatctc ttaaatactc ttccgtaata aatttcatca ttgaccttta ctcctcacct 8761 ttttcaaata aatacttttt taaagcatca attcctgttc ccatttcaaa gctaatatga 8821 aaatatggct ctgatacccc tatctttttt aattgcattt cacatttttc tttattctta 8881 ggcatcaaat cacattttgt tataacccca attactggac atctaaaaga ctttgcaaat 8941 ccatgggagt atatttcagt gcaattagat tggtcaacca atataagcac acaagatgca 9001 tcctgagctg ctgcaattat atgtttgtac atccatgcat tctctatata ggaacctgga 9061 acatcaatgg tattcttacc ataaattaaa tctggtgttc gccttaatgg accatcataa 9121 tcgtttaatg cattaactaa tgtagttttg ccgcattttg aagggccaat taccattatg 9181 cgcttttttc tcatgttctt gtaatgggag cggtggtaaa tccaagcata tcctttagcg 9241 tatcattaac tgcactaaga gctgtttcaa cactttgaac atcaccactt attacaacag 9301 agcctgtaaa acgatctaaa aatccaattt caacatcaga agcctttgta gcaatatctg 9361 ctgcaataat agctgtttca aagggtgata aagtcaaaat acctattgct cctttttcat 9421 caattccaag acgatcatat atatcaggca ttggtgatgc aataacatga gctatagtaa 9481 tctgctttcc tggcactgac tcttgtataa cacgctgtat atttctatca gaaaaatctc 9541 ccataaacct taccttccat cttattatct atttgaaaat tatttaatgg cggattacct 9601 ttacaggtaa atcatatttt ttaatccatc cttctattct atctaaatct tcacttttaa 9661 ggcttggatc atcttttata ggatattcca ttcctaattg gttatattta tttaccccca 9721 tcttatgata aggaagtaaa tcaattccct taaagttttt ataatcttta taaggtaata 9781 aaaattccat agttttttct atctcatctt gagaatcatt tataccttta agtaaaggca 9841 tacgaatctt tacattgtat tttttcttga gtaattcttg aagattttct aaaatcctct 9901 catttcttac tccagttaat tcatgatgtc tatcagaatt aatattttta atatcaaata 9961 agaatagatc tacaaattct gcaaccttaa ggattgtttc aagatttgta tagccacaag 10021 tttcaattgc agtgtttata ccttcttgct tacatgccat tagtaaacta gtagcagctt 10081 caggctgcat taaaacttcg ccaccaccta atgtaactcc accgccggac atttcataaa 10141 aagttctatc ttcttctact atttttaaaa gttcagagat agttttttct tctccaacta 10201 ttgatatagc agatttaaga caagcttctt tacactttcc acatcctata caatctatgt 10261 cacgattaac ttcatgcttt agagttttat tagaaatagt atggattcct acaggacatg 10321 cagaaacaca agctccacaa tttacacata gattactttt aagcataact ctatattttt 10381 tttctagtcc ttcaggattt gcacaccatt tacatctaag tggacatcct tgaaaaaata 10441 ctaaagttct tattccatct ccatcataca tattatattt ttgtatatta aaaatccttg 10501 cttttctctc gattatacct aaatttccat tactcatatt actcattctc cagtttcatt 10561 tactttgatt tttaatatat atcttaattg gtatctgcaa tctacaaaag aagttgtaga 10621 ttgcagactt tatataaatt attttaaagg gactaagtta tatattttct ataagttata 10681 tattttccat caaattttta ttagaaatgt gtaagcatag ttctacttat aatttcatct 10741 tgaacatctt tacataactc aacgaagaat gcactgtatc cagcaacacg aacaattaaa 10801 tcacgatatt gatctggatg tttttgagct tctattaaag tcttgttgtc taaatagtta 10861 aattgaactt ctccaagttg aagggcacaa gcactacgta ataatgtaat gattccttgt 10921 tctccttctg gtgtatcaag aagaccagct attaacttaa agttatgaac catacctata 10981 ttcatatctt cacaagacat cttagaaaca gattttatta tagaagtagg gcctttaaaa 11041 tcagcgcctt gtgatggact tataccatct gataaaggca tccatgctct acgtccattt 11101 gctgtagctc cagtcatttg tccaaatgga gtattgtttg atattgataa agtaccatga 11161 ctaagtactg aatataatgt cttatattta cgatgttctt gttctgtaaa gttaattaaa 11221 tcagcagcaa ttaaatctgc ataatcatca tcgttaccat acttaggtgc ttctaaacaa 11281 tcttttctta attgttcata tccaacgaaa tctgctttta aagcttcgtt catttcttgt 11341 agagtatatt ttttatcttc aaatactaat ttctttatag ctgccataga atctgcataa 11401 gtagcaagac cactccatac tactccaggt ccgaagttat acatagctcc gccggcttct 11461 actcctctac cattttccat acaaccttca tacatcatag acataagtgg ctttggagca 11521 agttctttat gaacacgttg agaaattact gtagcaacac ttgtccattt agtaatgaat 11581 ttaatttgtt ctttaacagc tgcttcaaat tgttcataag ttttaaactg gcttaagtct 11641 cccatatctg ggcatacttg tttaccatac cataatggta caccattgtt taaaacaagt 11701 tctatacata taggccattg agtgtatcct gtagaagtcc attgatatag tcttcctgat 11761 ttttgtggtt caacacatcc cattaagcag taatctcttg cgtcttctat agaaacacct 11821 ttagctaaca taatttttat atgaacatcg tcaaagtggc atgctgggaa tcccatacct 11881 gcacgaataa cgtcaactat ctttttaaga tatttttgtg gtgatgattt gtgtatacgg 11941 caagctaaag atggttgata tattttaaca tgacgaactg catccattaa aaggtatgtt 12001 aattcgtttg tagcgtcacg gccttctcta gtaacaccac ctacacacat atttacaaaa 12061 ggttgataac ctgcgaagaa tttagaacca ccttcacttg ttatccacat catttcagac 12121 atttttataa gcatacaacc tgataattca aatgcttcat aatcagtcat acgtccagct 12181 tcaatatcag ctttatagaa tgggtacata tattggtcaa cacgtcctat agacatacct 12241 gtttgatttt cctcaactac aagtaatgat tctatagtcc aaactgcttg aattgcttcc 12301 caataagtac ttggcttatg tgctggaact ctagcattta tttcagaaat cttttgaagt 12361 tctgctttac gcttagggtt agtttctttt tgagctaatt cagcagcata atctgacata 12421 cgtttagcat atatcataac accttcagca gtatcaatta atgatttgta gaaatagatt 12481 ttgtctatat cttctggatt ttcatattta agttcagcta atttttcttc tgcttctctc 12541 tttatgtcaa gcataccttt tttcattaat acaacgtcat atcctgggtt agagtctcct 12601 ccaccattta ctgcgtggta tgaacagtca gaaacaaaag attctcctga aagttcccat 12661 actcctgctt cacgatattg atcttcgcag tattcatcaa cggatttacc cgcccaatat 12721 gggaataact cctcacgcat gattttctta tcttcttctg agatgtagaa tgggtcttgt 12781 ggacgagttc ctattgtatc aatttcatca accatccatc tccaagctat atcaggagaa 12841 aatgctcctg cacgaggttg tccatttggt gctccaacta taagttcatt gtcttgaatt 12901 acaagtggtg cagtttcgca acaatgttta aaacatttac cacgtaaaac tgatttagga 12961 gtaccagggt tttcttttgc tattttagta atagctcttg ctctatgagt tgttattgtt 13021 ggaacatgtt ttagataagt ttcctttaac ttaactagac gttctgtcat tccatctggt 13081 atttcaccat tattgtcaca cgcaaccttt gatgtagctg gttcttcttt tgttatttca 13141 ttagaaacac tttgaaacat cttcattaat ccagcgcgtt cttcatcaga catattttta 13201 gtagcttcca taaatttatt tgaaaattca cgtatatcca atttattccc tcacattctt 13261 taatgtattt catatattaa atatgatttt ttattttaag tcctgtaaaa ctttttttaa 13321 aatactctct aataacttat agttatctat ttcatttcca tttaacttcc catttaaaac 13381 tgcagggata gaatcctctt tatcatttac tgttttaaca atttcatcca ccatgcgaac 13441 tccatatcca actttacgta tatataatag attcataggt gaaacattat ccgaagtcat 13501 tccctgacct gcagaaccac tacctaatgt cattgaagga aacaaatttg tagttgctcc 13561 catactccca aaagttcctg cagtatttac aagtactctc ccaacaggtt ttttaagtgc 13621 aaattgacga ataacttctt catcctttga atgtatcaca agtgtatgtc catatctttc 13681 agtaagtaat aattctatac atttttcaca agcgtgcatc cagtcatcct ctatataaaa 13741 ggctaaaact gggcaaagtt tttctcttga ataagggtta tttttagaaa caaacttctc 13801 attggaaata agcactttta caccttctga aacttgaaag ccagcctttt tagctaaaaa 13861 ctgtggagac ttaccaatca tctctaaatc tgggcttccg ttttgattaa acaaaatctt 13921 tcctagtttt aaagcttctt cttctgtcat aaaatatcca ccatttttaa taagttcttg 13981 ctttacttca gatgcaatta agctatctac aacaattgat tgttctgcag cagacacaac 14041 tccataatca aaattcttac tcgtaataat atctttaact gctttttcta tatcagctgt 14101 acgttctata aaggcaggtc cgtttccatt gcctccatat attactggct taccagattt 14161 ataggcttcg tcaagcattt ctataactcc agtgttcatt attaaagatg tatctttatg 14221 cttcataagc tctaatgaac cactttcagt tactgtgtga agatatgcaa gagcaccttc 14281 tggaagtcct acaccttctg cagctctaat taaaatatct actgttttag aaattgtatt 14341 tttagctctt ttatgaggtg aaaatataat tgcatttcct gactttattg caattaatgc 14401 tttatatata gtggtagata ctggacttgt tgctggtggg aaggctataa caacccccat 14461 tggtacacca acatccatgg ttttattaat tttatcttca ttgataatac ctacacacct 14521 catacctttg agtttgtttt ttaaatactc acatacaaag tgatttttaa catatttatc 14581 ttgccacttt ccatactctg tttcttcatt agatattttt gcaagctctt ttaaatgttt 14641 ttcaacttct tcagccatac gctcaactat ctcatcaagt ttttcttgtg ggaaagtagc 14701 taattttttt tgtgcctctc gggcattttc aacaagaatt ctagcttcct gcatggagag 14761 taaatcatta tctataatat tcatctttct ctctcctttt ctttagaaaa aattcatttt 14821 tctattctgt tataatatct gtaatggcat aacgttttat tattttttca agatcttcgt 14881 gtggtcttgg aataactatt gagctatata ggtttccacc ttccattcca ttaactgctg 14941 caacaccagc atctactgct gttttacaag caccaacatc accacgaact aatacagata 15001 tataacctga tgcaacattt tcatatccta taagttcaac atctgctgat ttgcacatag 15061 cgtctgctgc ttctaaagca aaaaccagac caaaagtttc gattaatcct aaagcttcat 15121 atcttgccat atgtatatca tttcctttct attttatgaa tcgatatcgt gtactgaaac 15181 aatatctcca acttctctaa taggacgtgg cataacattg tgtgctgtta atttaccgat 15241 agctctagct gcttcagcac ctgcttctac agcagatttt actgcaccaa catccccttt 15301 taccataatt gttacaaggg ttgaaccaat attttcataa gaaattaatt caacattagc 15361 tgccttaagc attttgtctg cagcctcaag tgcaggaact aatcctattg tttccacaag 15421 gcctaaagcc tcatctccat aatatctcat ttttaattcc tccttcctaa tttagcccaa 15481 tatacttttt cttaactata atatctatta ttaattcttc tattattctg tgtaggtttt 15541 catgcatttt ttcgttgcta tatgttgatt atatcccttc ccctttgggg gaaagtcaat 15601 atatttttta taataagaat ctttggataa tttgttgtaa atcacatatt ttaaagcaat 15661 ctttactttt aacattcact agttctgctt atgttattat gcttttatga gatttatttt 15721 gtataagcat tcccctatgg ttaatgttag aaattaatcc ggaatatact tattgattgt 15781 ttcagcacct tctgcatgtg catgatagta aactcttaac tcattattat tatctaaatc 15841 gaatcttgtt tcttcaataa gaccattagc ttctgctgta agtagtgcat taattacagc 15901 tttcttgttt aaagctttaa aatttccata ttgtcctttt aatgccttta taacatcatc 15961 agcacaagct tctgaaactt tagtaaaatg ttttaaaatt gcataattaa gcggtttcat 16021 ctatatctac ctccattttc tttcctttga ataaatcaag tggattcata gatattgtaa 16081 gaataccaaa catcattatt acagctccaa tccaagctac aggaggtaat gaccatccgt 16141 ccattccacc atatactcct aatactaata agcagaataa tggtccaaag aaagaatatg 16201 taccattgca tgcagtacca agtcctgctc cacacatact gtttccagca taccatgtca 16261 tgaatgttac aaatgataaa agtccactta aaacaaacca aaccattgca ggagaacttg 16321 taaatgcttt tatagcaaga tcagtagaga ttccaattcc accagccatc atcccgaaaa 16381 ttggaactaa gatgaataaa tttgctatac ctgatgttac ttgacgaata caaattccta 16441 tttcaggatc aatcattgct gtaccatatc cagctacaca accttcaaat ccccaaccta 16501 aagctgcaat aatagctatt gcaataccaa ttaatgtatt tgctgaagcc ccaccgctaa 16561 gacctgtact accaattaag aaactagcgc atacacatat taaaatacca aaagccatac 16621 gtttatttaa ttcttgcttg tacaaaattt tacctagtat agctgcaatt gcagggcaaa 16681 gagctgatat tggaacaact attgaaccag ccatttgaag tgctataaca taagctgtac 16741 cagctatagg tcctccgata agagctgcta atatcatgat acgtcccggc tttgtgttaa 16801 cgcatcttaa aaagtctcca aatttacctt taactcctgc atacaaaagt gaccaaatgg 16861 cactacatgt gtcgtttatt gcgttaccaa gagctgcaag caagtatgct atagcaaatg 16921 ctgataagcc tgctgtatta ggaccatacc agtcccccca aactccttta gtcataccca 16981 tagttaaaaa cgcagtgtat aatccatagg caagtcctga aaataaagct agggatatac 17041 cctttttgaa gaaatcactg gataatttct tctttgcagc aactgcttct aagcttactg 17101 cttttgaatc tccattcata aaataattct cctttcgctt ataaaaaatt aataatatta 17161 taaattcata ttgttaaata aaaatttata ataaatatac attaagattg ttataatttg 17221 gtgcattcta cattaaaatt actgaacacc ttttcacttt ctatcttgta ggtactttat 17281 tcttaagtag attatattcc ctgccctata gggtaaggtc aatatgtatt tttcaagaat 17341 atttaaataa gattaaaaaa attagtacta tatctaccaa taggaactca ataaatactt 17401 ctaaaccctt cattaagtta aagttacatt tgatgttttt aagtgataaa catagaaata 17461 cctggataat aatccaggta tttttaattc tataaaaaca ataaacttgt gctttgttta 17521 atattattgt gtttttttta acaaaaggag taccgttaac cctatatagt ctaccctagg 17581 gtcaacgttt tcaccagaat taaattattt ttctctacta atttttatta aaacttctgt 17641 tacaaatcta tctctatttt tagttgtcca ataatctgtt acatatcttt cataggattc 17701 ttcagaacat atataaccgt gtttttgagt ccaatccttt atttttttat atgtttcatt 17761 aatagtttca tgaggtccta tatgataaca agcagctacc atccaaccac caaattccac 17821 actcaattct tccctacatt ttaaaattgt ctcctgcatt attgtcatct tattgcattt 17881 tccattcatt ttatcttgaa agcatggaaa acgtatgatt acaggccctg ttattgcatt 17941 ttctatacta tctatgtaat ttgtaaattc tatgttaatt atagaatcca tatagtcata 18001 ttcaaaatct tgatctaaaa aagttaaagt acgattatct atgtatttta tagctacatc 18061 agaaacatta ttttcaatta ccatttgggc ttcaactata agatcatccc aatccttaac 18121 ggatcttaat tttaaattta tttctttttc aagttctttt aattcatcta ttttatttct 18181 aaaacttgta tgaaaaaaat cataggtctt tccttctaaa aaaactttca tttcttcaag 18241 cttaaatcca ctttgtttat aatattttat tactggaaca gataataaag tattcttgct 18301 ataatatctg taaccacttt catcagctac tttatcaggt gataatatgt ccattttgtc 18361 ataatatctt aatgcttttt ttgttatttt gcatatctta ccaactttac ctattgaata 18421 taattcgtct tccat //