LOCUS NC_008021:9 18192 bp DNA linear BCT 05-OCT-2011 DEFINITION Streptococcus pyogenes MGAS9429, complete genome. ACCESSION NC_008021 SOURCE Streptococcus pyogenes MGAS9429, complete genome. COMMENT locus start: 1681408; locus end: 1699599 FEATURES Location/Qualifiers source 1..18192 /organism="Streptococcus pyogenes MGAS9429, complete genome." gene complement(0..1628) /gene="isp" /locus_tag="isp" /db_xref="1681408..1683036" CDS complement(0..1628) /gene="isp" /product="immunogenic secreted protein" /translation="MKKRKLLAVTLLSTILLNSAVPLVVADTSLRNNTSSTDQPTTAD TDTDDESETAKKDKKSKETASQHDTQKDHKSSHTHPTPPSNDTKQTDQASSEATDKPN KDKNVTKQPDSSDQSTPSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKT PEKGPEKATEKTPEPNRDAPKPIQPPLAAAAPVFAPWRESDKDLSKLKPSSRSSAAYV RHWTGDSAYTHNLLSRRYGITAEQLDGFLNSLGIHYDKERLNGKRLLEWEKLTGLDVR AIVAIAMAESSLGTQGVAKEKGANMFGYGAFDFNPNNAKKYSDEVAIRHMVEDTIIAN KNQTFERQDLKAKKWSLGQLDTLIDGGVYFTDTSGSGQRRADIMTKLDQWIDDHGSTP EIPEHLKITSGTQFSEVPVGYKRSQPQNVLTYKSETYSFGQCTWYAYNRVKELGYQVD RYMGNGGDWQRKPGFVTTHKPKVGYVVSFAPGQAGADATYGHVAVVEQIKEDGSILIS ESNVMGLGTISYRTFTAEQASLLTYVVGGKLPRP" gene complement(1730..3118) /gene="ihk" /locus_tag="ihk" /db_xref="1683138..1684526" CDS complement(1730..3118) /gene="ihk" /product="two-component system histidine kinase" /translation="VRLIKKTFLVINGLIIVVVTSILLVLYFAMPIYYTKVKDKEVKR EFDQTSKQIKGKTVTEIRDILTKKINKDNIWYSLVDSDNQLLYPSLQLLDGVSESKDS QNVNIVTTFDNSYSNVKVMSQKVTLRDGKKMTLLGQSSLQPVTDASKVLLDLYPSLLI FSVTVGSIVAYLYSRTSSRRILSMSQTAKKMVNLEPNLTCTIHGKDEIAMLASDINRL YASLSTSIKSLQKEYEKASDSEREKSEFLRMTSHELKTPITSVIGMIDGMLYNVGDFA DRDKYLRKCRDVLEGQAQLVQSILSLSKIETLASQNQELFSLKSSLEEEMEVFLVLSE LKHLKVTINLEEQFVKANKVYLLKAIKNIIDNAFHYTKPGGQVMIQLKDNQLVIKNEA ETLLTQQQMKQLFQPFYRPDYSRNRKDGGTGLGLFITHQILDQHHLAYRFVVLDQRWM VFTIDFPSHHDD" gene complement(3115..3768) /gene="irr" /locus_tag="irr" /db_xref="1684523..1685176" CDS complement(3115..3768) /gene="irr" /product="two-component response regulator" /translation="MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTT SYDLIILDIMLPSLSGLEVLKTIRKTSDVPIIMLTALDDEYTQLVSFNHLISDYVTKP FSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTKKEYDIIDYLA KRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTGIPLKTITGMGYLLGERE" gene complement(3862..5079) /gene="" /locus_tag="" /db_xref="1685270..1686487" CDS complement(3862..5079) /gene="" /product="ABC transporter permease protein" /translation="MEDIIAALGSILSHKMRSILTMLGIIIGIGAIIAIFSIIEGNTE NTKRQLIGGSNNTINIVFNKKSSIDPKFPDKSNAKKPDYLPFMAEEELSKIQQVKGVK NALISYGIDDKVYHLGQKSSAKISAITKNVAEVRRMTFIKGSDFSDKDFIDQKQVIYL EKSLYESLFPKDDGLGKFVEVMGNPFRVIGVFESKEQSGLTSGTEKIAYIPLHQWYNI NGVVDATPEITIQTYRADDLKPVAKRVSDMLNQTIPKSDYMFGVMNLKEFERQLDNLN KSNFVLLAGIASISLIVGGIGVMNIMLVSVTERTREIGIKKALGARRKLILKQFLIEA VILTLLGGVIGVISGMVSGLIITRSLEYPYILSLFSVVLSLAFCCIIGIVFGLLPAIK ASKLDPIEALRFE" gene complement(5092..5766) /gene="" /locus_tag="" /db_xref="1686500..1687174" CDS complement(5092..5766) /gene="" /product="ABC transporter ATP-binding protein" /translation="LLNLKDIRKSYHLGTEEFAILKGIDLEVNEGDFLAIMGPSGSGK STLMNIIGCLDKPGSGSYAIEGRDVSSLSDNELADLRNQKIGFVFQNFNLMPKLTACQ NVELPLTYMNVPKKERRKRALEMLKLVGLEERSEFKPMELSGGQKQRVAIARALVTNP SFILGDEPTGALDTKTSVQIMDLFKQFNDNGKTIIIITHEPEVAALCKKTVILRDGNI EHSDIE" gene complement(5753..7021) /gene="" /locus_tag="" /db_xref="1687161..1688429" CDS complement(5753..7021) /gene="" /product="HlyD family secretion protein" /translation="MFQLRKKMTRKQLALLSAGVLTCVVGGTYLIMNHQQQEIVSSVN KVKALTIKEAMEQGKDISLTLAGEVTANNSSKVKIDSSKGEVKDVFVKKGDVVKVGQP LFSYETSQRLTAQSSEFDVQTKANQLQVAKTNAALKWETYNRKVNEINTLKSRYNTAP DESLLEQIRSAEDSVSQALSDAKTADSDVKTAQIELDKANATATMEKGKLEYDTVKSD TAGTIVSLNTDLPNQSKSKKENETFMEIIDKSKMLVKGNISEFDRDKLKIGQKVEVID RKDNSKKWTGKVTQVGNLKAEEKGQGQGQGGNDQQDNPNQAKFPYVIELDQSDKQPLI GSHTYVNVLNNVPEAGKIVLKETFTMAENGKTYVWKVDKNKVKKQEVKTKPFSKGYIE VTSGLTMQDKIAQPLPGMKDGMEVGSIVKP" gene complement(7445..7729) /gene="" /locus_tag="" /db_xref="1688853..1689137" CDS complement(7445..7729) /gene="" /product="hypothetical protein" /translation="MKFKKVLVIPALALAATCFLTACGTKKDSKKEEVKEIKMSDIKD DAVSKKTKVVDGEEVTEYTTKDGNVIQIPAGNEEGMESKDAGGSGAPAKN" gene complement(7877..8173) /gene="" /locus_tag="" /db_xref="1689285..1689581" CDS complement(7877..8173) /gene="" /product="hypothetical protein" /translation="MTKQDQLIVEKMEQTYEAFSPKLANLIEALDAFKEHYEEYATLR NFYSSDEWFRLANQPWDDIPCGVLSEDLLFDMIGDHNQLLADILDLAPIMYKHM" gene complement(8315..10282) /gene="" /locus_tag="" /db_xref="1689723..1691690" CDS complement(8315..10282) /gene="" /product="fibronectin-binding protein" /translation="MTKKFIKSAVILGLASITISMTQPVEAISNSLEYQAQYKRVKEE LDALKEKGPKLGERSLYFKVVNRFLGWFGVVWDPLAIKETDHLLDLIGQVNYLVSNTE FQAPEYQKAKNKLDLAVAGYDLYLAREKKRGDAPDYQVTQLTLGQLETIKTKIQEALK TFAQEVKTIQQKKPDLFPHAYVLNAKSKDITDKAQPFLVNGYYDVFYKQFLFTNTNDG YNYNKEADNLASYQKLIKELLGLKAEIDQLTKDDPKNDRLETLMWESKFTLSDSRRTS RLSAYYTQEDYVKKVVLSEEAPNLRTAKEKVKTLKGILHDYYVDIKEPEKAKKYRVED ETLPSQPEAPAKPEAPAPSPSPAPGQKPAEDERSSQATEPANPSKENSSTDASQGSHD SENPATDSPSQPQASDQGNHQSQVPNAKPQTDKTDTPNAPVPPQNTPNAPAIPQDTPK VPEAGGQSGPAGNAEEKAPDSGPKESGQSSSKESPSVGEDTTPNQPDVLVGGQREPID ITEDTITDAPPTVSGHNASTQPQSVVEDTAPQRPDVLVGGQSEPIDITQDTQPGMSGS NDATVINEDTKPKRVFHFDNKEPQASEKAAEQKLAPHDSHTTPQTSDDTAAPHLPASG DKPEKVFALAALTMVAAAGLLSKKRRNTDKN" gene complement(10462..11268) /gene="" /locus_tag="" /db_xref="1691870..1692676" CDS complement(10462..11268) /gene="" /product="fibronectin-binding protein" /translation="LEDVKMSYSKFKMPIPELDIEVVPIPEKPLVEPMTPLYPAIPNY PTPQLPKDEDLEISGGHGPIVDIVEDTGTGVEGGSQNGVVSTQENKDPIVDITEDTQP GMSGSNDATVVEEDTAPKRPDVLVGGQSDPIDITEDTQPSVSGSNDATVVEEDTAPKR PDILVGGQSDPIDITEDTQPGMSGSNDATVIEEDTKPKRFFHFDNEPQAPEKPKEQPS NSLPQAPVYKAAHHLPASGDKREASFTIVALTIIGAAGLLSKKRRDTEEN" gene complement(11280..13520) /gene="" /locus_tag="" /db_xref="1692688..1694928" CDS complement(11280..13520) /gene="" /product="fibronectin-binding protein" /translation="LTNCKYKLRKLSVGLVSVGTMLIAPTVLGQEVSNTEASASSTAS VDATASGTTASGASSEATVATTNGGSQSTQVAAETTPQPQVQTSEQPAATSTSLASST SSSEDKAPKAASTKSSSATVASSSNGSNQGAGTEVEPQMMDVEQYKVNKEKTELTVKD DNQQLKIRKDVDELKNKDLFDVKREVKDNGDGTLDVTLKVTPKQIDEGADVMALLDVS QKMTDADFNNAKEKIKKLVKTLTSKPTDSHPNHNARNSVRLMTFYREVSDPIDISGKT DEELNKILDDVWQNAKHNWDWGVDLQGAIHKARGIFKQDQEKKSGKRQHIVLFSQGES TFSYDIQKSEKERDNNLSRINEKITSSNPLLHWPPIFNHTHQNADMLNEIERIIKIGE QLGIKGLSSIKGYLSTAAAGSGILGNFIGGGSLTEYLTLKEYNSDKLEESQFDYTKRV GEGYYYYSFSKRVSHNDFPFKTLIEQAITQAIPTKGESKNWFEKFLDKFSLVESYRDT QKKALLKILEYLFYKREYHYYNHNLSAIAEAKMAQQEGITFYSVDVTDSETTPKRVRR QTAVRQEKAKKESKEERNEKFDKYLKKMSEGNTFLDSVEEKDKFKDTFTNVTVTETFE DKVSAIANSWESSLDSHNNKSDRNHKGSVKHTQAQSSGWFANTQESLTWTISKDQLKK AFEDGEPLTLTYKLKVDKDKFRETLKKQQERNRKNEQHLRKVRTLSQKKLFQIRFLTR LIMVRI" gene 13943..14179 /gene="" /locus_tag="" /db_xref="1695351..1695587" CDS 13943..14179 /gene="" /product="hypothetical cytosolic protein" /translation="MTHRFFLTPLSTLWRRLRPKRYSKKVLADEPTSYQPPTAHGPCD DTHQLLEDKSLSDDYLITTSAMRRLWYWGYSQIG" gene complement(14450..15403) /gene="" /locus_tag="" /db_xref="1695858..1696811" CDS complement(14450..15403) /gene="" /product="peptidyl-prolyl cis-trans isomerase" /translation="MRKEAQKDMKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMK GDTITVSDFYNETKNTELAQKAMLSLVISRVFETQYANKVSDKEVEKAYKQTADQYGT SFKTVLAQSGLTPETYKKQIRLTKLVEYAVKEQAKNETISKKDYRQAYDAYTPTMTTE IMQFEKEEDAKAALEAVKAEGADFAAIAKEKTIAADKKITYTFDSGETTLPAEVVRAA SGLKEGNRSEIITALDPATSKRTYHIIKVTKKATKKADWKAYQKRLKDIIVTGKLKDP DFQNKVIAKALDKANVKIKDKAFANILAQFAKPNQKQPAQK" gene complement(15435..15752) /gene="" /locus_tag="" /db_xref="1696843..1697160" CDS complement(15435..15752) /gene="" /product="hypothetical protein" /translation="MEQTVSIEKSPIDKGGHQRLLMMTSLRCQGKGLSSVEMGLSPFT IFGSYSSHTVARKQHSKIANVSFCSYMTTAKHHNLTYPKHSGFLTNSHNEQQHQKARL SYV" gene complement(15859..16164) /gene="" /locus_tag="" /db_xref="1697267..1697572" CDS complement(15859..16164) /gene="" /product="streptopain precursor" /translation="MEMHFVRTEPEARRIAETFCAENTQTKTPMRVQQLSYPSDTDHS GGELYIYALSPAGFIIVSGDTRAHTILGYSFDNNLDLNHDNVRSMVEAYQKQINSLD" gene complement(16166..17362) /gene="speB" /locus_tag="speB" /db_xref="1697574..1698770" CDS complement(16166..17362) /gene="speB" /product="streptopain precursor" /translation="MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAIT FIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILG YSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHY NQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTL SSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDY GPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGV GKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSA VVGIKP" gene complement(17634..17804) /gene="" /locus_tag="" /db_xref="1699042..1699212" CDS complement(17634..17804) /gene="" /product="hypothetical protein" /translation="MDNPKKDKGFSLGVVDPITILITESVINKMRTVPYHLKKLSSTT YCLLADLAYQSA" gene 17888..18019 /gene="" /locus_tag="" /db_xref="1699296..1699427" CDS 17888..18019 /gene="" /product="hypothetical protein" /translation="MLISVDKKLKNTDNINKMILLFVNAFIDFSFLSTTILQKELQK" ORIGIN 1 ttatggtctt gggagtttgc cccctacgac ataggtcaac aaactagcct gctcagctgt 61 gaacgtccga taggaaatgg tgcctagtcc cataacattt gactctgaaa ttaagataga 121 accatcttct ttgatttgct ctacaacagc aacgtgacca taggttgcat ctgctcctgc 181 ttggcctggt gcaaatgaga cgacatagcc cactttaggt ttatgggtgg tcacaaagcc 241 tggtttgcgc tgccagtcgc caccgttacc catgtacctg tcgacttgat aacctaactc 301 tttgacacga ttataggcgt accaagtgca ttggccaaag ctgtaggtct ctgacttgta 361 ggtcaaaacg ttttgtggct gacttctttt ataacctacg ggcacttcgc taaattgtgt 421 cccggaagtt atcttgagat gttctggaat ctcaggtgtg cttccatgat catctatcca 481 ttggtctagt ttggtcatga tatctgctcg tctttgccca ctgccacttg tatctgtaaa 541 gtaaacccca ccatcaatca aggtatccaa ctggcctagt gaccattttt ttgctttgag 601 gtcttgtctt tcaaaggttt ggtttttgtt ggcaatgatg gtgtcttcta ccatgtgacg 661 aatagcaact tcatcgctgt attttttggc attgtttggg ttgaagtcaa aggcgccata 721 accaaacata ttggcccctt tttctttagc aactccctga gtacctagtg agctttctgc 781 cattgcaata gctacgatag ctcgaacgtc tagtcctgtt agtttttccc attctaataa 841 acgcttcccg tttaagcgtt ctttatcata gtgaatacct agactgttca aaaaaccatc 901 tagctgttca gcagtgatcc cataacggcg tgacaacagg ttgtgagtgt aggcagagtc 961 acctgtccag tgtctcacgt aagccgctga tgagcgactg cttggtttta gcttgctcag 1021 gtctttgtca ctttctctcc acggtgcaaa gacaggagct gctgctgcta aaggaggttg 1081 gatgggtttt ggagcgtcac gatttggctc tggggttttt tcagttgctt tttctggtcc 1141 tttttcaggg gttttatcag ctgatttttc tggtgtttta tcaggtgtct gatctttttg 1201 ctgatcaggt gatggggtag gtcggccatc tttgttttgt gactcttttt gagacgactg 1261 gtctttggga gatggggtgg attgatcact gctgtctggt tgcttggtga cgtttttgtc 1321 tttatttggt ttgtcagtag cttcagatga tgcctgatcg gtctgcttag tatcatttga 1381 aggaggggtt gggtgagtgt gtgatgactt atggtctttt tgggtgtcgt gctgcgacgc 1441 tgtttccttg ctttttttgt ctttttttgc tgtttcactc tcgtcatccg tatcagtatc 1501 tgctgtagta ggctgatcag tggatgatgt gttattacgc aaggaggtgt cagcaacaac 1561 taatggcact gcactgttta agagtatggt acttaatagt gttactgcta acaatttcct 1621 tttcttcata tatgatttct ctcctctttt ttatacttgc ctaaataatg atgggtaaag 1681 gtcaaggctt ggttagtgat tgatgacttt tgtcgtccta ctagtgtgga tcaatcgtca 1741 tgatgggatg gaaaatcaat cgtaaatacc atccatcttt gatcaagaac aacaaagcga 1801 taagccagat gatgctgatc aagaatctgg tgggtgataa acagccccaa tcctgtacca 1861 ccgtctttcc tgttacgact ataatctggt cgataaaacg gttggaataa ctgtttcatc 1921 tgctgttgtg tcaataatgt ctctgcttca tttttaatca ctagttggtt gtcttttagt 1981 tgaatcatca cttggccgcc tggtttggta tagtgaaagg cattgtcaat aatattttta 2041 attgccttta gtaggtatac tttattggct ttgacgaatt gttcttcgag attgatagtc 2101 actttgaggt gttttagttc tgataagacg agaaagactt ccatttcttc ttctaggctg 2161 ctttttagtg aaaacagttc ttgattttga gaagctaggg tttcaatctt agataaagat 2221 aaaatggatt gaaccagttg ggcttgccct tcaaggacgt ctcggcattt tcgcaaatat 2281 ttgtcacgat ctgcaaagtc accaacatta tagagcattc catcaatcat tccgataaca 2341 ctggtgattg gtgtctttag ctcgtgcgat gtcatgcgta aaaactcaga tttctctctt 2401 tctgaatcag aagctttttc atactctttt tgcaaggatt tgatgctcgt tgaaagactc 2461 gcatacaaac ggttaatatc actagccaac attgctattt catctttgcc gtgaatggta 2521 cacgttaagt ttggttctag gttgaccatt tttttggcgg tttgtgacat gctaaggata 2581 cgccggctag aagtcctact atataagtag gcgacaatac tccctacagt cactgaaaaa 2641 atcaatagtg acgggtagag gtcaaggaga actttgctag catctgttac gggttgaagt 2701 gaagattgcc caagcaatgt catttttttt ccatcgcgta gggttacttt ttgactcatc 2761 accttaacat tagaataaga gttgtcaaag gtggtgacga tattaacatt ttgactgtct 2821 ttgctttcac tgacgccgtc taacagttgc aaggaaggat agagcagttg gttatcactg 2881 tctactaagc tgtaccaaat attatctttg ttgatttttt ttgttaggat atctctaatc 2941 tcggttaccg tcttgccttt gatttgcttg cttgtttggt caaattcacg cttaacttct 3001 ttgtctttga ctttggtgta ataaattggc attgcaaaat aaagcactaa caaaatagag 3061 gtaaccacta caataattaa gccattgatg accaaaaagg tttttttgat tagtctcact 3121 cacgctctcc caataaatag cccatgcctg taattgtctt gaggggaata cccgtcattt 3181 ttttacgaag gttcttgatg tggttgtcaa ggacacgcgt gtccagttca gaatagcccc 3241 atatgtcatc catcaattgg tctctggtga caatcttttg gtgacgtttt gctaaataat 3301 caataatgtc atattctttt ttggttagtt tgaccaatgt tccttgccaa tagacgctat 3361 gttcggtctc atcaacaagt aagtctccga tttggcgctt ttcatctgga gtagagacgc 3421 gtaatacatt ttcgatacgt ttgattaaaa tgagtggtga aaatggttta gtcacataat 3481 cactaatcaa atggttgaag cttacaagct gtgtgtactc gtcatctaat gccgttagca 3541 taataatagg gacatctgat gtctttcgaa ttgtttttag cacttctaag ccacttaagg 3601 aagggagcat gatgtctaaa ataatcagat cataagacgt tgtctgccac ttgtctaagg 3661 cagcttggcc atcaaataca caatctggat catagttatt cgcttttaaa aactcacaaa 3721 tcacttgact gatggtatca tcatcttcaa ctactaatat tttaaacata acttcccttt 3781 ctagattggc gtttagtgta tcaagcagct aaggatgaca tcaaagggtc atcctttttg 3841 acttttatgc ttgtttggtt gattattcaa atcgcaatgc ttcaattggg tctagcttag 3901 acgctttaat ggctggtaat agtccaaaga caatccctat aatacaacaa aacgctaaac 3961 tcaagacaac tgagaacaag gataggatat agggatactc gagtgatctt gtgatgatca 4021 atcctgatac catccctgaa ataaccccta tcacaccacc tagcaaggtt agaatgaccg 4081 cttcaattaa aaattgtttt aaaataagct tacgtctagc gccaagcgct tttttgatcc 4141 caatttctct cgttctttcg gtaactgata ctagcataat gttcatcaca ccaataccac 4201 ctacaataag agagatgcta gcaataccag ctaataacac aaaattagat ttgtttaggt 4261 tgtctagttg gcgttcaaat tctttaaggt tcatgacacc aaacatataa tctgatttag 4321 ggatcgtttg attgagcata tcactgacac gctttgccac aggtttgagg tcatctgcgc 4381 gataggtctg gatcgtgatc tcaggtgtcg catccactac accattaata ttataccact 4441 gatgtagcgg gatataagca attttctcag tcccacttgt gaggccactt tgttcttttg 4501 attcaaacac cccaatgacc ctgaagggat ttcccatcac ttcgacaaat tttccaagac 4561 catcgtcttt tggaaatagc gactcataca agcttttttc aaggtaaatc acctgttttt 4621 ggtcaataaa gtctttgtct gaaaagtcac tgcctttaat aaatgtcatg cgtctcactt 4681 cagctacgtt ttttgtgatg gcagaaatct ttgcagatga tttttggcct agatggtaga 4741 ctttgtcatc aataccatat gagatcaggg cgtttttgac gcctttgact tgctgtattt 4801 tgctaagctc ttcttcagcc ataaaaggaa gatagtctgg ttttttagca tttgacttat 4861 ctggaaattt aggatcaata ctgctttttt tgttaaacac aatgttaata gtgttattgc 4921 tgccaccaat caactgtctt ttggtatttt cggtattacc ttcgatgatt gaaaagattg 4981 cgataatggc accaataccg ataataatcc ctagcattgt caaaattgac cgcatcttgt 5041 gtgataatat agagcctaaa gctgcaataa tatcttccat tattttcccc ctttactcta 5101 tatcggaatg ttctatatta ccatctctta ggatcaccgt ctttttgcat aaggcagcta 5161 cttcaggctc gtgtgtgatg ataataatcg ttttgccgtt atcattgaat tgtttaaata 5221 ggtccatgat ttggacgctg gtttttgtgt ctagtgcacc tgttggctca tcaccaagga 5281 taaaactcgg attagtgact aaagctcttg caatcgctac acgctgtttt tgcccaccag 5341 atagctccat cggtttaaat tcactacgtt cttctagtcc tactagtttt aacatctcta 5401 gggctcgttt gcgacgctct tttttaggaa cattcatata agtcaagggc aattcgacat 5461 tttgacaagc tgttagcttg ggcatcaggt taaagttttg aaaaacaaag ccgatttttt 5521 gattacgcaa atcagcaagt tcattatcag ataaggatga cacgtctctg ccttcaatgg 5581 catatgagcc agagccaggc ttatctaaac acccaatgat attcatcaat gttgactttc 5641 ccgaacctga tggtcccatg atggctaaaa agtcaccctc gttaacttct aaatcgattc 5701 cttttaaaat cgcaaattct tcagtcccaa gatgatagct ttttcgaata tctttaaggt 5761 ttaacaatac ttcctacctc cataccatct ttcatgccag gaagcggctg agcaatctta 5821 tcttgcatag tcaagccact tgtcacctca atataacctt ttgagaaggg cttagtcttg 5881 acttcttgtt ttttgacctt gtttttatca actttccaca cataggtttt tccattttct 5941 gccattgtaa aggtttcttt caatacgatc ttgccagctt ctggaacatt gttgagcaca 6001 ttaacatagg tgtgtgagcc aatgagtggc tgcttgtctg attggtcaag ttcaataaca 6061 taagggaatt ttgcttggtt tggattgtct tgttggtcat tgccaccttg gccttgacct 6121 tggccttttt cctctgcttt gaggttgcca acttgggtta cttttccagt ccatttttta 6181 gagttgtctt tgcggtcaat cacttcgact ttttgaccga tttttaactt gtcacggtca 6241 aattcactga tgttaccttt gactaacatt tttgatttgt cgataatttc cataaaagtt 6301 tcattttctt ttttggattt tgattgattt ggcaaatcag tatttaggct aacaatggtt 6361 cctgcggtgt ccgacttaac ggtgtcatac tctagtttac ctttttccat tgtggcagta 6421 gcattagctt tatcgagttc gatttgagcg gttttgacat cgctatctgc tgttttggca 6481 tcgcttagtg cttgggatac actgtcttct gcgctgcgaa tttgctctag taagctctca 6541 tctggtgcag tgttgtagcg agattttagg gtattgatct cattgacctt gcgattgtag 6601 gtttcccact tcaatgctgc attggtttta gcaacttgga gttgattggc tttggtttga 6661 acatcaaatt ctgaactttg agccgttaac cgttgtgacg tttcatagct aaacaagggt 6721 tgtcctactt tgacaacatc gccttttttg acaaagacat ctttgacttc tcctttactt 6781 gagtcgattt tgactttgct gctgttgtta gcggttactt cgccagctaa ggtcaagctg 6841 atatcttttc cttgttccat ggcctctttt atggttaagg cttttacttt gttgacacta 6901 gagacaattt cttgttgttg atgattcatt atcaagtagg taccaccaac cacacaggtc 6961 aacactccag cactcaacaa ggctaattgt ttgcgcgtca ttttttttct taactgaaac 7021 atactttctc ctcaatagct attttttctt tttatacgat ttttatggtt ataccatacc 7081 aacgttatcc cttttgaacg gtcactagca agacctacta gtcatgatga cgcttaacac 7141 caacgattaa tccgatgacc aacagtaaga tgacaggtat aatggatctt tttttcattt 7201 tagcacttcc tttttcgtag cttgaaacac gacaaactgg ctattttagc gttcttttct 7261 tgtttttgga aaacaaaaat catataaccg ttcgctcaca taagcacggg tatatgattt 7321 tgtacatttg cgagttagtg tgtttggcta tttaggcatt atgataagtg agttaccatc 7381 ttaggcagac tgcctcatgt catgcgtaac gtttgcgagt caccttatgc tctttgttgt 7441 aacccttagt ttttagcagg agcgcctgat ccaccagcat cttttgattc catgccttct 7501 tcgtttcctg caggaatctg aatcacgttt ccatcttttg tggtgtattc tgtaacttct 7561 tcgccatcaa ccacttttgt ttttttgcta actgcgtcgt ctttgatgtc agacattttg 7621 atttctttaa cttcttcttt tttagaatct ttctttgtgc cacaagctgt taaaaagcat 7681 gttgctgcta atgctaatgc aggaatgact aatacttttt tgaatttcat gatgaaatgc 7741 tccttttgtt ttgatacctt tagtttaaca gacgcatcta ctgtttttct aacgattatc 7801 tgttttttat ctgttttttt tgagatttgc tagctttttt tgtcctatca tcgtagtatc 7861 tgtgacgtta gcgatgatta catatgcttg tacatgatag gggccaagtc taagatatca 7921 gctagtagtt ggttatggtc accgatcata tcaaagagga ggtcttcaga taggacaccg 7981 cacgggatat catcccaagg ttggtttgca agccgaaacc attcgtcact actgtaaaaa 8041 tttctaagtg tggcatattc ctcataatgc tctttaaagg catctagggc ttctatgaga 8101 tttgctagct ttgggctaaa ggcctcatag gtttgttcca ttttttcaac gattaactga 8161 tcttgctttg tcatgggttg ctcctttgct gattattacc tttattttac accgaaatgc 8221 tagcaattgt catgaaaaac cctctatttg ataaaaacct aactaaggcc agtgcaaatg 8281 cactggcctt agtgatgcgt tgtgtctaac agcgactagt ttttgtcggt gttgcgacgt 8341 tttttgctga gtagccctgc agctgcgacc attgtcaagg cagcaagtgc aaacactttt 8401 tcaggcttgt ctccagatgc aggcaagtga ggggctgctg tatcatctga agtttgaggg 8461 gttgtgtggc tatcatgagg agcaagtttt tgctctgccg ctttttctga tgcttgtggc 8521 tctttgttat caaagtggaa gacgcgtttt ggttttgtat cttcattgat aacggtagcg 8581 tcattagagc ctgacatgcc cggttgggta tcttgggtga tatcgattgg ctcgctttga 8641 ccacctacaa ggacatctgg gcgctgaggt gctgtatctt cgaccacaga ttggggctgt 8701 gttgatgcgt tgtgcccaga tactgtcgga ggagcgtcag tgattgtgtc ttcggtgata 8761 tcaattggct cacgttgacc acctacaagg acgtctggct gattaggggt cgtgtcttcg 8821 ccaacggatg gggactcttt agatgagctt tgaccagact ctttaggtcc agagtcagga 8881 gctttctcct cagcgttccc agcggggcca ctctgaccac cagcctcagg aacttttggg 8941 gtgtcctgtg ggatggctgg ggcgttagga gtgttctgtg gagggactgg ggcgttagga 9001 gtgtccgtct tgtccgtttg aggcttggcg ttaggcactt ggctttggtg attgccttgg 9061 tctgatgcct gaggttgaga aggactgtct gtcgctgggt tttcactatc gtgagatccc 9121 tgagatgcgt ccgttgagga attctctttt gacgggttag ctggctccgt agcttgtgat 9181 gatctctcat cttctgctgg tttttgacca ggagcaggac taggactagg agcaggagct 9241 tcaggtttag caggggcctc aggttgagac ggcaaggtct cgtcctcgac acgatacttt 9301 ttagcttttt ctggctcttt aatgtcaaca tagtaatcat gcaagatccc ttttaaggtc 9361 ttgacctttt cttttgctgt tctcaagttg ggagcttctt cagataggac cacctttttg 9421 acataatctt cttgtgtata gtaggcgcta aggcgtgaag ttctccgtga atcagataag 9481 gtgaactttg attcccacat taacgtctct aaacgatcgt ttttaggatc gtcttttgtt 9541 aactgatcga tctcagcttt taagcctaat agctctttaa tcagcttttg atacgaagcc 9601 agattgtctg cttctttatt atagttgtag ccgtcatttg tattagtgaa taaaaactgc 9661 ttataaaaga catcgtagta accattcact aaaaagggtt gcgctttatc tgtgatatct 9721 ttgctcttag cgtttaaaac ataagcatgg ggaaataggt ctggtttttt ttgctggatc 9781 gttttgacct cttgtgcaaa tgttttcagg gcctcttgta tcttcgtttt gatggtttcg 9841 agctgtccta gcgttagctg ggtcacttgg taatcaggag catcaccacg ttttttctct 9901 ctagctaggt agaggtcata gcctgctaca gctaagtcta gtttgttttt agccttttga 9961 tactcagggg cttgaaactc ggtgttactc accaagtaat tgacttgtcc gatgaggtcc 10021 aacaggtgat cggtttcttt gattgcgagt gggtcccaga ctacgccaaa ccaacctaga 10081 aatctattca ccactttaaa ataaagggaa cgttccccta attttgggcc cttttctttt 10141 aatgcgtcta gttcttcttt gacacgttta tattgtgctt gatattctaa actatttgaa 10201 atggcttcaa cgggttgcgt catgctgatg gttatgcttg ctaagcctag aatcactgct 10261 gatttaataa attttttagt catatttcat cattatacct ttttacttgt tgtgataccc 10321 attaatcccc ctcaaccgta ggggatacct gatttaagac tagcggcttt tttaagcgcc 10381 atctcagtga ggtaccggtg tttgaggggg ataatgagaa atttttaaag ccaaaggctt 10441 agggtcgcta gactaacgag ggttagtttt cttcggtgtc gcgacgtttt ttgctgagca 10501 aacctgcagc tccaataatt gttagagcaa caattgtaaa ggatgcttca cgtttgtctc 10561 cagatgcagg caagtgatga gctgccttat agactggagc ttgtggtaag ctgttacttg 10621 gttgctcttt gggtttttct ggtgcttgtg gctcgttatc aaagtggaag aagcgttttg 10681 gtttcgtatc ttcttcgata acagtagcgt catttgagcc tgacatgcct ggttgggtat 10741 cttcggtgat atcgattgga tcactttgac cgccaacaag gatatctgga cgtttaggtg 10801 ctgtgtcttc ctcgacaact gtcgcgtcat ttgagcctga cacacttggt tgggtatctt 10861 cggtgatatc gattggatca ctttgaccac caacaaggac atctggacgt ttaggtgctg 10921 tgtcttcctc gacaactgtc gcgtcatttg agcctgacat gcctggttgg gtatcttcgg 10981 tgatgtcaac gattggatct ttattttcct gagttgaaac cacgccgttt tgagagccgc 11041 cctcaacacc tgtaccagta tcttcgacga tatcgacaat cggtccatga cctccactaa 11101 tctccagatc ttcatctttt ggaagttgag gggtagggta attaggaatt gcaggatata 11161 gaggcgtcat tggttctacc agtggttttt ctggtattgg tacaacttct atatcaagtt 11221 ctggtatagg cattttgaac ttgctgtaag acattttaac atcttccaac ttattgttat 11281 ttatatcctt accattatta atcttgtaag aaatcttatt tgaaataatt ttttctgtga 11341 cagtgttctc actttccgga gatgctgctc gttttttcta ttacgttctt gttgtttttt 11401 aagagtttct ctaaatttat ctttatcaac tttaagctta taggtgaggg ttagcggttc 11461 tccatcttca aaggcttttt tgagctggtc tttggaaata gtccaagtga ggctttcttg 11521 ggtattggca aaccatccgc tgctttgagc ttgtgtatgt ttgacacttc ctttatgatt 11581 tctgtctgat ttgttattat gactatctag cgaagattcc caagaatttg ctatagcgga 11641 aaccttatct tcgaaggttt ctgtcactgt tacattggtg aaggtgtctt tgaacttatc 11701 tttctcttca acactatcta agaaagtatt accttcagac atctttttca gatatttatc 11761 aaacttttca ttgcgctctt ctttggattc ttttttcgct ttttcctgac gtactgctgt 11821 ttgtcgcctc actcttttag gagttgtttc tgaatcagta acatcaacgg agtagaaggt 11881 gatgccttct tgttgagcca ttttggcttc agctatcgct gaaagattgt gattatagta 11941 gtggtattca cgcttataaa aaagatattc aagaatcttt aataatgctt ttttttgagt 12001 gtctcgataa ctttccacca atgaaaattt atctaaaaat ttctcgaacc aatttttact 12061 ttcaccctta gtaggaatcg cttgtgtgat agcctgctct attaaagttt taaaagggaa 12121 atcgttgtga cttactcttt ttgagaagct ataataatag tatccctcgc ccacacgttt 12181 ggtgtaatca aattggcttt cttctaattt atcagagtta tattctttaa gagttaagta 12241 ttctgtaaga cttcctccac cgataaaatt tcccagaatc ccgctacctg ctgctgccgt 12301 acttaaatac ccttttatac tagaaaggcc ttttatacct agttgctccc ctatctttat 12361 aatcctttcg atttcattta acatatctgc attttgatgc gtgtggttaa aaataggtgg 12421 ccaatgtaac aaagggttag aagaggtaat tttttcattt atacgagata aattgttgtc 12481 tctctctttc tcactctttt gaatatcata actaaaagtc gactcacctt gagagaacaa 12541 gacgatatgc tggcgtttac ccgatttttt ttcttggtct tgcttaaaaa tccctcgagc 12601 cttatggata gctccttgca agtcaacccc ccagtcccaa ttatgtttag cattttgcca 12661 cacatcgtct aatatcttat tgagttcctc atccgtcttt cctgatatat caattgggtc 12721 actaacctca cggtaaaagg tcattaggcg cacagagttg cgagcattat ggtttggatg 12781 actatcagta ggtttactcg ttaaggtttt gactaatttc ttgatttttt ccttagcgtt 12841 gttaaaatca gcatctgtca tcttttgaga gacgtctaaa agggccataa catcggcacc 12901 ttcgtcaatt tgtttaggtg ttacttttaa ggttacatct aaggttccgt cgccattatc 12961 tttcacttca cgtttgacat caaaaagatc tttatttttt aattcatcaa catctttacg 13021 gatcttgagc tgctggttgt catctttaac agtaagctct gttttttcct tattaacctt 13081 atactgttcc acgtccatca tctgtggttc aacttcagta ccagcacctt gattgctacc 13141 attactagag ctagccacag ttgctgaaga tgatttagtg cttgctgcct taggagcttt 13201 atcttcacta ctactagtag aagaagccaa tgatgtggat gtagctgctg gttgttctga 13261 agtctgtact tgaggttgtg gagtcgtttc agctgctact tgagtagact gacttcctcc 13321 attggtagta gctacggttg cttcactact agctccgctg gcagtcgtcc cacttgccgt 13381 agcgtctacg ctagcggtac tactagcact agcctcagta ttactaacct cctgtcctaa 13441 aactgtcggg gctatcagca tcgttccaac ggagacgagc cctacagata actttctaag 13501 tttatactta caatttgtca atgtttcgtt aaccttactt tcattattat gtcataattg 13561 ttccgaaact tattatacac catacttttt tgttcccaaa atcagttttt tggtgagaga 13621 aaaattaatg atctcttaga tagacaagag tcttttctct gtcatgacag ctgtgtcaga 13681 ctcgttgaga cgaaaaaagg ggttgccgcg atagcctata ggacaataat ggtatcgcta 13741 tcattagctt ggaggcaact gagtgcgcag atagctgcgc aaggagaagc tcaaatgcga 13801 ggggtattta gagtctttat tagggtcgcg tttttttaac aaaggaaagt ttgtgacctt 13861 gatttttaat ctttttctcc ttaaaataac attattgaca cttttgtctg ttaaggtgac 13921 tatcattaga caaggaggcc aagatgaccc atcgtttttt tctcacccct ctctcaaccc 13981 tctggcgccg tctgagacca aagcgttact ccaaaaaagt tttggctgat gagcctacta 14041 gctatcagcc accgacagct catggcccgt gcgacgatac tcatcagttg cttgaggaca 14101 agagcttatc agacgattat ctgattacta cttctgcgat gagacgcctc tggtactggg 14161 ggtatagtca gattgggtaa ggagagtttc tgactcccaa tcagctagtt taacggacta 14221 tcactgatac cattcacgct aagcctcatt ctaggcttag cgtgaatttt tttgctgact 14281 ggttttaaaa cattaaagac tctatcctta tttggataga gtctttagct ttatgacatt 14341 gccctagacc atcagtatag gacacgtttc cattatcggt gttttgaaaa ggggagtgat 14401 ggctagggct gtctttttaa gcaaccttag ggaaataaac tggcaacctt ctatttttgg 14461 gcaggttgtt tttggttagg ttttgcaaac tgggctaaga tattggcaaa tgctttgtct 14521 ttgattttga catttgcttt atcaagagct ttagcgatga ctttgttttg gaagtcaggg 14581 tcttttaatt tgccagtcac aatgatgtct ttcaagcgtt tttggtacgc tttccagtct 14641 gcttttttag ttgctttttt ggtgactttg atgatatggt aggtgcgttt tgaggtggct 14701 ggatcaagcg ctgtgatgat ttctgatctg ttcccttctt tgaggcctga tgcagctcta 14761 actacttctg ctggtagggt tgtttcgcct gagtcaaacg tgtaggttat ttttttatcg 14821 gctgcaatgg ttttttcttt ggcaatagct gcaaagtctg ccccttcagc tttgacggct 14881 tcaagggctg ctttggcatc ctcttctttt tcaaactgca tgatttctgt ggtcatggtt 14941 ggggtataag cgtcataggc ctgacggtag tctttttttg agatggtttc gtttttggct 15001 tgttctttga cggcatattc gactaatttt gtgaggcgaa tttgtttttt ataggtttct 15061 ggcgttaagc ctgattgtgc taggactgtc ttaaaggagg taccgtattg gtctgcggtt 15121 tgtttatagg ctttttcaac ctctttgtca gagactttgt tggcatattg tgtctcaaat 15181 acacggctaa tcaccaagct taacatggct ttttgtgcga gttctgtgtt tttggtctca 15241 ttgtagaagt cactgacagt gatggtgtct cctttcatcg agacgagttt ggtgttgttg 15301 tgtgatgatt gacaagctga taaggtcacg actgtcgcca gcgttaccac tcctgtaatg 15361 agtttattca tttgtttcat gtccttttga gcctcttttc tcattaataa ttactgttat 15421 cttatatcat tagtcttaaa cgtagcttaa tcttgctttt tggtgttgct gctcgttgtg 15481 actgttcgtt agaaagccac tgtgtttagg ataggttagg ttgtggtgtt tggctgtagt 15541 catgtatgaa cagaaactga cgttggctat ttttgagtgt tgttttcttg ccacggtatg 15601 gctagaataa ctcccaaaaa tcgtaaaagg actgagtccc atctctacag aactcagtcc 15661 tttaccttgg catcttaggg aagtcatcat tagtaggcgt tgatgacctc ctttatcaat 15721 gggtgacttt tcgatggaaa cagtctgctc catgagacaa acacttgctt aggccggcgt 15781 gaaacttaaa aggtagtggt attttagaaa cacggtcgtc ttaaacgagt ggtgaggggg 15841 caaaagctac tttgaccgat caatccaaag agttgatttg tttttggtaa gcttctacca 15901 tacttctgac attatcatgg ttgaggtcca ggttattatc aaaagaatag cctaaaatgg 15961 tgtgcgctct ggtgtctcct gatacgatga taaatccagc aggagacaaa gcatagatgt 16021 atagctcacc acctgagtga tctgtgtctg atggatagct taactgctgc acgcgcatag 16081 gggtttttgt ttgtgtgttt tcggcacaaa aggtttcagc tatgcggcgt gcctcaggtt 16141 ctgttctaac gaaatgcatt tccatactaa ggtttgatgc ctacaacagc actttggtaa 16201 ccgttgaagc cgcctgcgcc gccaccagta ccaagagctg aagggtttag tgcgtcaaga 16261 cggaagaagc cgtcagagac tccaccccaa ccccagttaa catggtagaa gttacgtccg 16321 tcagcaccat cgataacaaa ggcatgtccg cctactttac cgacaccttg gtagtatact 16381 ggttggtttt gagataattc tttgtcaatt tgtgcttccc aatcttgttt gctaaagtcg 16441 ctacggttaa tttggtgaac agattggttg tagccaaagt tttctttcaa ggctctttga 16501 acacgagagc tacctgcaga accactagat ggaccataat ccatgtctac tgaaatacca 16561 acatcagcca tcaattctga aatcgccatt ttttgaacgt tagattctct tccgctataa 16621 gtaggtagga tgttgttcca gttgtattgt ctagtagaga tagctgcaaa caagttctta 16681 ggatggttga aatatgggtt atttgagctt agtgtgtaag tgtagtcttt caaccctttg 16741 ttagggtaat tatgatattt cataatttga gcagttgcag tagcaacaca tcctgtagct 16801 gcatgttgac ctacaaaaga ttgttcacct ggttttactt tttcaataac aggtgtcaat 16861 aggttgtaag ggttaccttg gttgtaatga atgccttttg aatcaaggag agatttaaca 16921 actggttgtt taatctcagc ggtaccagca taagtagtgt ctaatttttt gttttctttg 16981 atttgttcga cataactttc catgaaggaa gcaatgtttt ctttaccgtt agcgtcaaat 17041 gatccgctgg tagagtatcc tagaatttct ggagaacgtt tatctcctga aacgataaca 17101 aatcctccag tagaaatatt gtaaacatac atattagagc cagaaagttc tccacctaag 17161 ttaactttgt caagcttaat atcttctgcg cttcgtgcac ctgctttgat agctgctgat 17221 ttttggataa atgtgatagc gctatctttt gcttcttttt cgttacgagc aaagttttga 17281 tcggcaaata ctgggttagc aagaacaaat ccacctaatg ctaaaagact taataatctg 17341 atacctaatt tctttttatt catttttttt atacctcttt caaaataagt taatctactg 17401 catttgcttt taacggtaca ttggacacac ctccttactt agctgaatcg tatggttatc 17461 atacgatgtc gctgatacca tgaatggtaa tagacaataa cacggttagt tgacactgac 17521 aacccaaccc aattattctc atctcatgtg agcctaattg gttttggtca aaagacgcta 17581 tgagtcgttg cacttatcat cttttggttg atctcttatc ttctgccgta tctgctaggc 17641 agactgatag gcaagatcag ctagcaaaca ataggttgtg cttgacagtt tttttagatg 17701 atatgggacc gttctcattt tgttaataac tgattctgtg ataaggatcg tgatagggtc 17761 cacaacacca agtgaaaatc ctttgtcttt ttttgggttg tccattagtt gactcgtagg 17821 ctttttcctg gctgatttat ctcattttta ctgacaatta gccttttagt tactattgtg 17881 gctagtagat gctcatttca gttgacaaga aacttaaaaa tactgataat ataaacaaaa 17941 tgattctttt gtttgtcaat gcttttattg acttctcatt tttatctact accattttgc 18001 aaaaggaact acaaaaatag taacaataac cacatagtag gcgcctcctt ttaaccttat 18061 ggctatatca tagctgctta ttttgctaac ccattatttt gttacgtatt aggtacacac 18121 gtaacgtatt tttaacatct attagattag aaaggtttaa catatgacag ttgataaaac 18181 tatcgcatct gg //