LOCUS NC_004557:4 18061 bp DNA linear BCT 18-AUG-2011 DEFINITION Clostridium tetani E88, complete genome. ACCESSION NC_004557 SOURCE Clostridium tetani E88, complete genome. COMMENT locus start: 162670; locus end: 180730 FEATURES Location/Qualifiers source 1..18061 /organism="Clostridium tetani E88, complete genome." gene 0..1403 /gene="mesJ" /locus_tag="mesJ" /db_xref="162670..164073" CDS 0..1403 /gene="mesJ" /locus_tag="mesJ" /product="cell cycle protein mesJ" /translation="MIDIVLNTIHKYNMINKGDKIIVGVSGGPDSMCLLHILYRLRDE YNLNIIAAHINHCLRGKDADNDEKYVENFCKKYDIDFYSTKIDVGKLAKKENISFEVA GRECRYDFFNKLKLKFNCDKIALAHNSNDQCETILMRIMRGTGIEGLAGIKAIRDNIY IRPIIEASRKQIEDYCEEHELEARIDKTNLESIYARNKVRLELIPYIQENFNQDIIAV INRMGNNIDVDREYLDFASDKKFYQFCTSTKYEVVIKKEAFLEHKAITSRIIRRSINR LKGNLYNFERVHVEDILNLQKGSTGKFITLPEKIKALNNYGDIHIFFEEFSDNKGENK EKEQILEIGNNIINSNIKVQIELTNEIHKDIMGKDVYVKYFDFDKINGNIMFRYRKDG DRFTSLGMKGSKKIKDLFIDFKIPKHLRDYVPLICFGNEIAWIVGYRISEKFKVEKNT KNILKIKIEGEKENELV" gene 1390..1935 /gene="" /locus_tag="" /db_xref="164060..164605" CDS 1390..1935 /gene="" /locus_tag="" /product="hypoxanthine-guanine phosphoribosyltransferase" /translation="MNWCEGDIKEVLYNEEELRKKIKEMGKKITEDYKGKDLILIGVL KGSVIFMADLMKEINIPCNMDFMAVSSYGNSSETSGVVRILKDLDFEIENRDVLIVED IVDSGVTLRYLVDYLKGRKPASIEIVCLLNKEERRQSNIDVKYIGFDVPDYFLVGYGL DFAERYRNLPYVAILKEEVYS" gene 2034..3845 /gene="ftsH" /locus_tag="ftsH" /db_xref="164704..166515" CDS 2034..3845 /gene="ftsH" /locus_tag="ftsH" /product="cell division protein ftsH" /translation="MNNKKFSSATAWVIIFVFVIFASLYLARNNETATTITFNKFQKH WINNEIKSFEVKEDKMTVSGNLKDGSQYETIVPFERLNQFISAHDKNGEVIEKYALPA KTPMWLNWIPTALVILMFVIFWFMFMQQSQGGGGNRNVMNFGKSRAKMATPDKQKVTF NDVAGAEEEKEELAEIVDFLKQPKRYIEMGARIPKGVLLVGPPGTGKTLLAKAIAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFDQAKKNSRCIIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFGVNEGIIMVAATNRPDILDPALLRPGRFDRQILVGAPDVR GREEILKVHSRNKPLSEEVKLDVLAKRTPGFTGADLENLMNESALLAVRKDKKQIDME ELEEAVTRVIAGPEKKSRVIDEEDRRLTAYHEAGHAVVMKLLPHADPVHQISIVPRGM AGGYTMHLPEKDRAYMSKSKLEEEIVGLLGGRVAEKLIIGDISTGAQNDIERATTIAK KMIMDYGMSEVLGPIAFGSGHDEVFLGRDFGKSKDFSEEVASKIDKEVKGIIDTAYDR AQNLLMENINKLHAVAKELLEKEKLEAEEFEEIFESN" gene 3963..4346 /gene="" /locus_tag="" /db_xref="166633..167016" CDS 3963..4346 /gene="" /locus_tag="" /product="dihydrolipoamide acyltransferase" /translation="MAINLKEGISSIVEITVEEKDTAIIHGSGDLEVLATPVMIGLME KASKICVTPYLEEETTTVGIGIDIKHLKATPLKMKVRSEATLYKVDGKKLFFNVQAWD EKGTIGEGTHVRYIVNSKKFMEKLK" gene 4526..5314 /gene="" /locus_tag="" /db_xref="167196..167984" CDS 4526..5314 /gene="" /locus_tag="" /product="putative transcriptional regulator" /translation="MILVLDAGNTNMVLGLYEDKNLIADWRLSTDPLRTADEYSIQVI QLFLQSNLRLEDVEGVIVSSVVPNIMYSVEHMVAKYFKKKPIIVGPGTKTGINIKYDN PKEVGADRIVNAVAAHEIYKKPLVIIDFGTATTFCAVTQSGDYLGGAIAPGVKISSEA LFEKAAKLPRVELMKPSSVICKNTVSSMQAGMTYGYGGLVDHIVSKIKQELMDSGEKE PLVVATGGLAKLISEESETIDIIHPFLTLEGLRIIYEKNKDLDA" gene 5314..6282 /gene="nifR" /locus_tag="nifR" /db_xref="167984..168952" CDS 5314..6282 /gene="nifR" /locus_tag="nifR" /product="nitrogen regulation protein nifR3" /translation="MKISRLELKGNVFLAPLAGVTDLAFRGLCKRMGCTLVYTEMVSA KALFYDSDKTKDMLRFSKEELPIAVQIFGKEPDIMANVVEKYFNSNDNVCLIDINMGC PAPKIVKNGEGSALMKNPKLASDIVESIKKVSTKPVTVKFRKGFDNDNINALEFAKIM ENSGADALTIHGRTREQMYQGKADWEIIKKVKESVKIPVIGNGDVFTGEDAINMIEST NCDGVMVARGALGNPWIFNQISEALKGQQILEPSPDEILEVCIEHFKRALYYYDEKKA VREMRKHIGWYIKGLKNCSKVKDTINKEVDKDKVLNILEEYRKEFV" gene 6309..7172 /gene="" /locus_tag="" /db_xref="168979..169842" CDS 6309..7172 /gene="" /locus_tag="" /product="hypothetical protein" /translation="LNQFRLRRYMKDIIYISGYNQNKIYNKNDIITNIIDKMKIKFDR SIFIKDLGIKILNVKMPYNINSVAYNRNFKRIIERKRYKDYSIAPKVWRKKDFKYFNS FQKDLFSYSVSKSIQLILRLQNKSIKNSTILVYDPLDEGMKEIIKFICIMAKNLIFLT EDISKVIKISECISANYGIAPIITKDKEYALKYSDFVVTSRNIKTYDKLIWYIDNLYE VDCKSIKAVNDVYYNVPWNIFSENNISIEVLGAILNEMEEKNVEKALKYNGIELRNIK FNDRNINFTRY" gene 7188..7748 /gene="greA" /locus_tag="greA" /db_xref="169858..170418" CDS 7188..7748 /gene="greA" /locus_tag="greA" /product="transcription elongation factor GreA" /translation="MLIYNNVNDFDENYYFYKKDLKGENDMSDSKKYVMTYEGVKKLE EELEYLKTVKRKEITQKIKVALSFGDLSENSEYDEAKNEQAFVEGRIIQLENMLKNAT IVDENEMPADTVNVGSIVKVKDFEFNDEEEFIIVGSAEADPLENKISNESPVGKALIG KKAGEKVEVIVPDGISKYEIISVRRN" gene 7765..9273 /gene="lysS" /locus_tag="lysS" /db_xref="170435..171943" CDS 7765..9273 /gene="lysS" /locus_tag="lysS" /product="lysyl-tRNA synthetase" /translation="MSNEEKNLMNEEQEFNQLIQERRQKFFDLQAEGKDPFEVTKVER THTSEEIKSNFEELEDKEVTVAGRLMSKRVHGKAGFSDIHDRYGKIQLYIKINDVGEE RLKEYKSFDIGDFVTITGTVFKTRTGEVSIHITDFKLIAKSLKPLPEKWHGLKDPDLR YRQRYVDLIVNEDVRDTFMKRTKIIKYMREFLDAKDYIEVETPVLSPIAGGAAARPFT THHNALDIDMYLRIATELYLKRLIVGGFEKVYEIGKNFRNEGIDIRHNPEFTMIELYE AYADYNDMMEITENMVAYIAEKVCGNTKVKYEETEIEFRPPWKRITMVDSVKEYSGVD FNEIKTDEEARELVKGKDFELKKKLEDCTKADILNLFFEEYVEKNLIQPTFVCDYPVE ISPLSKKKNDNPEYTERFEGFVYGRELCNAYTELNDPIVQKERFIQQLKERELGDDEA FMMDEDFINALEIGMPPTGGLGIGVDRLVMFLTDSHSIRDVILFPTMKPTHN" gene 9480..9554 /gene="" /locus_tag="" /db_xref="172150..172224" CDS 9480..9554 /gene="" /locus_tag="" /product="tRNA-Asn" /translation="SVVAQWWSIRLLTEGLKVRILSTE" gene 9838..11229 /gene="" /locus_tag="" /db_xref="172508..173899" CDS 9838..11229 /gene="" /locus_tag="" /product="glycyl-tRNA synthetase" /translation="MTVEKTMDKIVALAKNRGFIFPGSEIYGGLANSWDYGPLGVEFK NNVKKAWWKKFVQESPYNVGIDAAILMNREVWVASGHVGGFSDPLMDCKECKARCRAD KLIEDYMQDKDENFESADGWSNEQLKDFIDKNNIACPKCGEHNFTDVRKFNLMFKTFQ GVTEDAQSEIFLRPETAQGIFVNFKNAIRTTRRKMPFGMAQIGKSFRNEITPGNFTFR TREFEQMELEFFCKPGTDLEWFEYWRDYSWNFLLSLGLAKDNLRIREHAKEELAFYSK ATVDIEYLFPFGWGELWGIADRTDYDLKQHMNHSGKDLTYLDPETNEKYLPYCIEPSL GADRVALAFLVDAYDEEELDGGDSRTVLRLHPALAPFKAAILPLTKKLKDKSLEVYSM LSKYFNVDYDEAGTIGKRYRREDEIGTPYCITIDYDTLEDNTVTIRDRDSMDQIRINI DELVKYISEKVEF" gene 11592..12986 /gene="murD" /locus_tag="murD" /db_xref="174262..175656" CDS 11592..12986 /gene="murD" /locus_tag="murD" /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase" /translation="MSMEGKMNKDFNEFKKFIYNKKVAIIGLGISNMPLVEFLSNLGA RVTGFDKKNENELENNINELKAKGVNFELGENYLDKLSNFDVVFRTPSMRTDHPILIK AKSEGAYITSEMEEFIKYCPAKLFCITGSDGKTTTTTLIYNILKTEGYTVWVGGNIGN PLFTKIEEIKKDDKVVLELSSFQLMSIKEPIEVALVTNVSPNHLDIHKDMEEYIKAKK NIFKYQRENDLLVINEDNKITKSMEEECRGRLLKFSMKEKLKEGSFYYNEDLYINEKK VCNVSEVKLKGMHNVENLLAAFSCVSEDSSIDSMREVAKNFNGVEHRLEFVKEIQEVK YFNDSIASSPTRTLAALQSFDRPVILIAGGYDKKISFEVLAKEGISHIKHLILLGDTK YKIEEAFKKVMRDSSEDLPISICNSIEEAINIAKENGESGDVVTLSPACASFDMFKNF EERGNKFKSIIRNL" gene 13443..14951 /gene="" /locus_tag="" /db_xref="176113..177621" CDS 13443..14951 /gene="" /locus_tag="" /product="16S ribosomal RNA" /translation="ESLILAQDERWRRA*HMQVER*SFLREVD*RRTGE*HVGNLPQR GE*PSERRINTA*S*GFA*NFNQRSNLL*DGPAPH*LVGKVMAYQGDDG*PT*EGDRP HWN*DTVQTPTGGSSGEYCAMGETLTQQRRVGDEGFRIVKPCFLGR**RYQMRKPRLT TCQQPR*YVGGKRCPDLLGVKGA*ADA*VRCEIPKLNLGAAFQTGHLEYRRGKRNS*C SGEMRRD*EEHQWRRRFPGL*LTLRHESVGSKQD*IPW*STP*TMNTRCRRVQPSVPQ LTH*VFRLGSTVARLKLKGIDGGPHKQRSMWFNSKQREEPYLDLTYPELLVTEEVPSG TGIQVVHGCRQLVS*DVGLSPATSATLIISCYH*VEHSNETARVNREEGGDDVKSSCP LCLGLHTCYNGRYRETQDREVEQISKTDPSSDCRLKLACMKPELLVIANQNVAVNTFP GLVHTARHTMRVGNTRSP*GNRKEPAAEGGVNDWGEVVTR*P*ENLRLDHLL" gene 15216..18060 /gene="" /locus_tag="" /db_xref="177886..180730" CDS 15216..18060 /gene="" /locus_tag="" /product="23S ribosomal RNA" /translation="SSYKGHMVNALAPVADEGRDKLR*ASGRRK*PVIRRFPNGETCI PNGMYRKLNT*ICGGIPGELKHLSTRRKRKKNRFS**RRAKRKEPKPEIYFWGCG*TI MKTDFNRRELERSTTEGNSPVGKKLCLLGLIQSTTRHVKPCGKQGGPPPKAKY*LVTD SEAVP*GKGEKNPGRGVK*NLKPYAYKQWEHVNV*PRAFCRTSQRVTVCSKVKHLRCV AEGKPSLNRATSCMP*TRNRVTYPWAG*SGSKIPWRTEPRWC*KTMG*PVDSGEIPIE LGDSWFSSK*L*G*RLVIE*WR*STEWARG*QQLLNPIKLRMPYTFIQAVRLRVIRSV VERETTQTIS*GPKV*VKWKRMWDF*DN*DVGLEAATHLKSA**LTSQEILRRRCPGL KLTTEAMDSIEW*RSFLYG*KSYRKKRWTVQE*VCWHE*REISENLIGRKPKVS*GRF VRSGLVGT*AQAERRR*WTIG*YSDTANFRLTNGVTQKDKVCTLLDVCLST*ACLIGK SVKLS*GVMGSLFWRSA*FHTVKKSLYGECWCPYRKPTQVGEERILRPSEELLLRN*A N*PRNFGRRGAMETWPQ*IGPSNCLAKTQVSAKAKADV*GLTPARCWKVKGIR*RKRS GELKPQ*TAAVTITVLR*RNSLSGKFRPARMA**LGHCLNSKSGEIVVQVKMLATRDR TERPRRALL*LNIEFRYCLYRIGGRLRSRSVSFCGVILGIPP**Y*NSNRGP*IWSRD IVRWAV*LGRSPPKK*RRRPKVPSARSEIARRV*RHKGA*LRHIQVEQGRKSGLVIRW FLVGGPSLNG*KLPRG*QADLPQESTSTGRFGTSMSARRILGLE*VPRVGLFAH*SGT RAGFRTS*DSSVPIRRGRRKFEGSCP*YERTGMD*PLVHQLSRQWHSWVAKSGRDKR* KHLSVKPTLR*DFP*RKSIRSLEEHKVDRSEV*V" gene complement(17072..17728) /gene="" /locus_tag="" /db_xref="179742..180398" CDS complement(17072..17728) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MRRADIEVPNLPVDVDSWGRSACYPRGSFYPLSDGPPTRNHRIT KPDFRPCSTCMCRSQAPLCLYTLRAISDRAEGTFGRLRYFLGGDRPSQTAHLTMSRDQ IHGPRLEFQYYQGGIPRMTPQKLTLLLLSLPPILYRQYRNSMLSYSKALRGLSVLSRV ASIFTCTTISPDLLLRQCPSHYAIRAGRNLPDKEFRYLRTVIVTAAVHWGLSSPLRLR" ORIGIN 1 atgatagaca tagtcctaaa tacaatacat aaatataata tgataaataa aggagataag 61 ataatagtag gagtatcagg tggacctgat tctatgtgct tattacatat attatataga 121 ttaagggatg agtataattt aaatattata gcagcccata taaaccattg tctaagagga 181 aaagatgcag ataatgatga aaagtatgta gaaaactttt gcaaaaaata cgatatagat 241 ttttattcta caaaaataga tgtaggaaaa ttagccaaga aagaaaatat atcctttgag 301 gttgcaggaa gagagtgtag atatgatttt ttcaataaac taaaattgaa atttaattgt 361 gataaaattg cattagcaca caactctaat gaccaatgtg aaacaattct tatgaggatt 421 atgagaggaa caggaattga aggacttgca ggaataaaag ctataagaga taatatatat 481 attagaccta taatagaagc aagcaggaaa caaatagagg actattgtga agaacatgaa 541 ttggaagcta gaatagataa aactaattta gaatctatat atgctagaaa taaagtaaga 601 ctagagctta taccttatat acaagaaaat tttaatcaag acataatagc tgtaataaat 661 aggatgggaa ataatattga tgtagataga gagtatttgg attttgcaag tgataaaaaa 721 ttttatcaat tttgtaccag tactaaatat gaagtagtta ttaaaaaaga agctttttta 781 gagcataaag ctataactag tagaattata agaagaagca taaatagatt aaagggtaac 841 ctatataatt ttgagagagt tcatgtagag gatatattaa atcttcaaaa aggatctaca 901 ggaaagttca ttactcttcc agaaaagata aaagcattaa acaattacgg agatatacat 961 atattttttg aagaattttc agataataag ggtgagaaca aagagaaaga acaaatatta 1021 gaaattggaa ataacataat aaattctaac ataaaggttc agattgaact aacaaatgaa 1081 atacataaag atataatggg aaaagatgta tatgtaaagt attttgattt cgataaaatt 1141 aatggtaata taatgtttag gtacagaaaa gatggagata gatttacatc tctaggaatg 1201 aagggaagta aaaaaataaa agatttattt atagatttta aaatacctaa acatcttaga 1261 gattatgttc ccttaatatg ttttggaaat gaaatagcat ggattgtagg atacagaata 1321 agtgaaaaat ttaaagtaga gaaaaataca aaaaatatac taaaaataaa aatagaagga 1381 gagaaagaaa atgaactggt gtgaaggcga cataaaagag gttctttata atgaagaaga 1441 attgagaaaa aaaattaaag aaatgggaaa gaaaataact gaagattata aaggaaaaga 1501 tttaatatta attggagtgt taaaggggtc tgttatattt atggcagatt taatgaagga 1561 aataaatata ccatgcaata tggattttat ggctgtgtct agctatggaa attcaagtga 1621 aacctcagga gtagtgagaa tattaaaaga tttagatttt gaaattgaaa atagagatgt 1681 acttatagtt gaagatatag tagattctgg agtaacatta agatatcttg ttgactatct 1741 aaaaggcaga aaaccagcta gtatagaaat agtttgttta ttaaacaaag aagaaagacg 1801 acaaagcaat atagatgtta aatatatagg ttttgatgtt ccagattatt tccttgtggg 1861 atatggcttg gattttgcag aaaggtatag aaatttacca tatgtagcaa tattaaaaga 1921 agaagtttac agttaattta ctatggtttt aatatcaata atgttgtaaa gccataattc 1981 atatgataca attttacagt ataattatta actagtagaa aggggggcca tccaatgaac 2041 aataaaaagt tttcaagtgc aacggcctgg gttattattt ttgtttttgt gatttttgca 2101 tctttgtatt tagctagaaa caatgaaaca gcaacaacta ttacattcaa taagtttcaa 2161 aagcattgga ttaataatga gataaaaagt ttcgaagtaa aagaagataa aatgactgtg 2221 tcaggtaatt tgaaggacgg gagtcaatat gaaactatag ttccctttga gaggttaaat 2281 caatttataa gtgcccatga taaaaatgga gaagttatag aaaaatatgc attacctgca 2341 aaaacaccta tgtggttaaa ttggataccg acggccttag ttattttaat gtttgtgata 2401 ttttggttta tgtttatgca acaatcgcaa ggtggcggtg gaaatagaaa tgttatgaac 2461 tttggtaaaa gtcgagccaa gatggcaacg ccagacaagc agaaagtcac ttttaacgat 2521 gtggcaggtg cagaggaaga aaaagaagag ttagcagaaa ttgtagattt tctaaaacag 2581 cctaaaagat atattgaaat gggagctaga atacctaagg gagtgttact agtaggtcct 2641 ccaggtacag gtaaaacttt actagcgaaa gctatagcag gtgaagcagg agttccattt 2701 tttagtatat caggttcaga ttttgtggaa atgtttgttg gggtaggagc atcaagggtt 2761 agagatttat ttgatcaagc taaaaaaaat tcaagatgta taatatttat agatgaaatt 2821 gatgcagttg gaagacaaag aggagcagga ttaggtggag gtcatgatga aagagagcaa 2881 acactaaatc agcttttagt tgaaatggat ggatttggag ttaacgaagg aattataatg 2941 gttgcagcaa ctaatagacc agatattttg gacccagcct tattaagacc gggaaggttt 3001 gatagacaaa tattagttgg agctccggac gttagaggca gagaagaaat attaaaagta 3061 cattcaagaa ataaaccttt atctgaggaa gtaaaactag atgtattagc taaaagaact 3121 ccaggattca caggtgctga tttggaaaac ttaatgaatg aatccgcatt attagcagta 3181 agaaaagata aaaaacaaat agacatggaa gaattagaag aagcagtaac tagagtaata 3241 gcaggacctg aaaagaaaag tagagtcata gatgaagagg atagaagatt gacggcttat 3301 catgaagcag ggcatgctgt agttatgaaa ttattacctc atgcagatcc agtacatcaa 3361 ataagtatag tacctagagg tatggcagga ggatatacta tgcatcttcc tgaaaaagat 3421 agagcgtata tgtcaaaatc taagttagaa gaggaaatag taggattact gggaggaaga 3481 gtagcggaaa aactaataat aggagatata agtactggag cacaaaatga catcgaaaga 3541 gcaactacta tagccaagaa aatgattatg gattatggta tgagtgaagt gcttggtcca 3601 atagcatttg gaagtgggca tgatgaggta ttcctaggta gagactttgg aaaatctaaa 3661 gactttagtg aagaagtagc atctaagata gataaagaag ttaagggtat aatagacaca 3721 gcatatgata gagcccaaaa cttactaatg gaaaatataa ataaacttca tgcagtagcc 3781 aaagagcttc tagaaaaaga aaaattagaa gcagaagaat ttgaagaaat atttgaaagt 3841 aattaaaaca gaggtttccc tctgtttttt tatgttataa atatactaat attttctaat 3901 aaatggttaa tatatgatat aatttatatg aagtaaaaat ggaaaaagaa aagggatgag 3961 tttatggcaa ttaatttaaa agaaggtata agttcaatag ttgaaataac tgttgaagaa 4021 aaagatacag ctataatcca tggttctgga gatttggaag tattggcaac accagttatg 4081 ataggattaa tggaaaaggc atctaaaatt tgtgtaacac cttacttaga agaagaaacg 4141 accactgtag gaataggtat agatattaaa catttaaaag caactccttt aaaaatgaaa 4201 gtaagatcag aagctacttt atataaagta gatggtaaga aactattttt caatgttcaa 4261 gcttgggatg aaaaaggaac gataggagaa ggaacacatg taagatatat agtaaatagt 4321 aaaaagttta tggaaaaatt gaaataagga tataggctac aatataaaga tatctgtact 4381 ttttaattta cagatatctt tttttaactt ataatggttt gtgtaatata agaaatatga 4441 ataattatat aaaaatataa cataatacaa aagtaaacaa tgttatgtat ttttgtaagt 4501 acatatcaaa ggagtggtga aggctaatga tattagtttt agatgcaggt aatactaata 4561 tggttttagg actttatgaa gataaaaacc ttatagctga ttggagatta tcaactgacc 4621 ctttaagaac tgcagatgaa tatagcatac aagttataca attgttttta caaagtaatt 4681 taagactaga ggatgtagag ggagttatag tatcatcagt tgtacctaat atcatgtatt 4741 ctgtagagca catggtagct aagtatttca agaagaagcc tattatagta ggacctggca 4801 caaaaacagg tataaatatt aaatatgata atcctaagga agtaggagca gatagaatag 4861 ttaatgctgt tgctgctcat gaaatatata agaaaccgtt agttataata gattttggta 4921 ctgcaactac gttttgtgcg gtaactcagt caggagatta tttaggagga gctatagcgc 4981 caggtgtaaa aatatcttct gaagcattat ttgaaaaagc tgctaaatta cctagagttg 5041 agcttatgaa gccatctagc gtaatatgca aaaatactgt atccagtatg caagcaggaa 5101 tgacttatgg atatggagga ctagtagatc atatagtatc aaaaataaag caagaattga 5161 tggattcagg agaaaaggaa cctttagtag tagctacagg tggtttagct aaattaataa 5221 gtgaagaatc agaaactata gatataatac acccattctt aactcttgaa ggtttaagaa 5281 taatatatga aaagaataag gatttggatg cttaatgaaa atatctagac tagaactgaa 5341 agggaacgtt tttttagccc cactagcagg ggttacagat ttagctttta gaggtttatg 5401 taaaagaatg ggatgtactc ttgtatatac ggaaatggta agcgcaaagg ctctttttta 5461 tgacagtgac aaaaccaaag atatgttacg cttttctaaa gaagaattac ctatagcagt 5521 acagatattt ggcaaggaac cagatattat ggcaaatgta gtggaaaaat attttaatag 5581 taacgataat gtatgtttga tagatataaa tatgggatgt ccagctccta aaattgtaaa 5641 gaatggagaa ggatcagctc taatgaaaaa tccaaaattg gcatcagata ttgtagagag 5701 cataaaaaaa gtttctacta aaccagttac agtaaagttt aggaagggat ttgataatga 5761 taatataaat gctttagaat ttgctaaaat aatggagaat tcaggtgcag atgctttaac 5821 catacatggt aggacaagag aacaaatgta tcaaggaaaa gcagattggg aaatcataaa 5881 gaaagttaaa gaaagtgtta agataccagt aataggcaat ggagatgtat ttacaggtga 5941 agacgcaata aatatgattg aaagtactaa ttgtgatggt gtaatggtag ctagaggagc 6001 tctaggaaac ccatggatat ttaatcaaat aagtgaagca ttaaaaggac aacagatatt 6061 agaaccttct ccagatgaga tattggaggt ttgtatagaa cattttaaaa gggctttata 6121 ttattatgat gaaaaaaaag cagtaagaga aatgagaaaa catataggtt ggtatataaa 6181 aggattaaaa aattgtagca aagtaaaaga tactataaat aaagaagtag ataaggataa 6241 ggtattaaat atattagaag aatatagaaa agaatttgta taatgaaaat ataattagca 6301 tatactttat tgaatcaatt taggttaaga aggtatatga aagatataat atatataagt 6361 ggctacaacc aaaataaaat ttataataaa aatgatatta ttacgaatat aattgataag 6421 atgaaaataa agtttgatag aagcattttt ataaaagatt taggtataaa gatattaaat 6481 gtaaaaatgc catataatat aaattcggta gcatataata gaaattttaa aagaataata 6541 gagagaaaaa gatataaaga ttattccata gctccaaaag tatggaggaa aaaagacttt 6601 aaatatttta atagttttca aaaagattta ttttcatata gcgtaagcaa aagtattcag 6661 ctaatattaa ggttacaaaa caaaagtata aaaaatagca ctatattagt atatgaccct 6721 ttagatgaag ggatgaaaga aataattaaa tttatttgta ttatggcaaa aaatttaatt 6781 tttttaacag aggatataag taaagttatt aaaatttcag aatgtatttc tgcaaattat 6841 gggatagctc cgataataac aaaagacaaa gagtatgcat taaaatatag cgactttgta 6901 gtaacttcta gaaatataaa aacctatgat aaactaattt ggtatataga taatctttat 6961 gaggtagatt gtaaaagtat aaaggcagtt aatgatgttt attataatgt accatggaat 7021 attttcagtg aaaataatat atctatagaa gtattaggag ctattttaaa tgaaatggaa 7081 gaaaaaaatg tagaaaaagc actaaagtat aatggaattg aattaagaaa tattaaattt 7141 aatgacagaa atataaattt tactagatac taagttgaca ttaaaattat gctgatttat 7201 aataacgtca atgattttga cgaaaactat tatttttata aaaaagatct aaaaggagag 7261 aatgacatga gtgattcaaa aaagtatgtt atgacatatg aaggggtaaa aaaactagag 7321 gaagaattag aatatttaaa gaccgttaaa agaaaagaaa ttacacaaaa aataaaggtt 7381 gcactatcct ttggggacct aagtgagaac tcagaatatg atgaagctaa aaatgaacaa 7441 gcttttgttg aaggcagaat aattcagctt gaaaatatgc ttaaaaatgc taccatagta 7501 gatgagaatg aaatgccagc cgatactgta aatgttggaa gtatagtgaa agttaaagat 7561 tttgaattca atgatgaaga agaatttata atagtaggtt cagctgaagc agacccatta 7621 gaaaacaaaa tttctaatga atcaccagtt ggcaaagctt taataggcaa aaaagcagga 7681 gaaaaagtag aggtaattgt acctgatggt ataagtaagt atgaaataat atcagtaaga 7741 agaaattaat tggaggaatg ctagcatgtc aaatgaagaa aagaatttaa tgaatgaaga 7801 acaagaattt aatcagctta ttcaagaaag aagacagaag ttttttgatc ttcaggctga 7861 aggaaaagat ccttttgaag taacaaaagt agaaagaact catacttccg aagaaataaa 7921 aagtaatttt gaagaactag aagataaaga ggttactgta gctggaagac taatgtctaa 7981 aagagtacat ggtaaagctg gtttttccga tattcatgat agatatggga aaattcaact 8041 ttatattaaa ataaatgatg taggagaaga aagattaaaa gaatataaat cttttgatat 8101 aggagatttt gttactatta caggaacggt atttaaaacg agaacgggag aagtttctat 8161 acacataaca gactttaagc ttatagcaaa gtctttaaag ccattaccag aaaaatggca 8221 tggactaaaa gatccggatt taagatatag acaaagatat gtagatttaa ttgtaaacga 8281 agatgtaaga gatactttca tgaaaagaac taaaataata aaatatatga gagaatttct 8341 agatgctaaa gattacatag aagtagaaac acctgtacta tcaccaatag cagggggagc 8401 agcagctaga ccttttacaa cacatcacaa tgcattagat atagatatgt atttaagaat 8461 tgctactgaa ctttatttga aaagattaat agttggtgga tttgaaaaag tatatgaaat 8521 aggtaaaaac tttagaaatg aaggaataga tattagacat aaccctgagt ttacaatgat 8581 tgaattatat gaagcatatg cagattataa tgatatgatg gaaataacag aaaatatggt 8641 agcttatata gcggaaaagg tttgtggaaa tacaaaagta aaatatgaag aaacagaaat 8701 agaatttaga cctccgtgga agagaatcac aatggtagac tctgttaaag aatattctgg 8761 agtagatttc aacgaaataa aaacagatga agaagcaaga gagcttgtta aaggaaaaga 8821 ctttgaatta aagaaaaaat tagaagactg tacaaaagca gatattttaa atcttttctt 8881 tgaagaatat gttgaaaaga atttaattca acctactttt gtatgtgatt atccagttga 8941 aatatctcct ttaagtaaga aaaagaatga taaccctgag tatacagaaa gatttgaagg 9001 atttgtgtac ggaagagaat tatgtaatgc atatactgag ttaaatgatc ctatagtaca 9061 aaaagagaga tttattcaac aattaaaaga aagagaatta ggtgatgacg aagcatttat 9121 gatggacgaa gactttatta atgctttaga aataggtatg cctccgacag gtggcttagg 9181 gataggagta gacagattag ttatgttctt aacagattct cattcaataa gagatgtaat 9241 tctattccca actatgaagc caacacataa ttaataaaaa aaactgcgac acagtttttt 9301 attaagtgaa cagtaaacag tgaataacta tggataaatt tttcattatc attataaaaa 9361 actttaaaat acataaaatt tttacgttga ttattcattg tttattgtta tttgttcatt 9421 aaataaaaaa agtggttgca ttataaaaaa tatgtgttat aatagttatt gtatcaacgt 9481 tccgtggtag ctcaatggtg gagcattcgg ctgttaaccg aagggttgaa ggttcgaatc 9541 ctttccacgg agccattttt attttttgac tattgataaa attaacatat ttgatagaat 9601 atattataat tgaatatacc acgatgatag agaagagtaa ctatataaac tttaaagaga 9661 ggttatgggt ggtgtaaata actaagtttt tattgtgaat ggagctcaag agtgtaaaat 9721 gtagagcagg gctgttgcca aaaagggtgg aaccgcggaa gttttctttc gtcccttatg 9781 gtagcagttt tttttataca aaaaaataag attattaata attaaggagg ataataacat 9841 gacagttgaa aagactatgg ataagatagt agcattagct aaaaatagag gatttatatt 9901 tcctgggtct gaaatttacg ggggtctagc aaactcttgg gattatggtc ccctaggagt 9961 agagtttaaa aataatgtta aaaaagcatg gtggaaaaag tttgttcaag aatcaccata 10021 taatgtaggg atagatgcag caatactaat gaacagagaa gtatgggtag cgtcaggaca 10081 cgttggggga ttttcagatc ctttaatgga ttgtaaagaa tgtaaagcaa gatgtagagc 10141 agataaatta atagaagatt atatgcaaga taaagatgaa aactttgaaa gtgcagatgg 10201 atggagtaat gaacaactaa aagattttat agataaaaat aatatagcat gtcctaaatg 10261 cggagaacat aattttactg atgtaagaaa gtttaattta atgtttaaaa cttttcaggg 10321 agtaacagaa gatgctcaat cagaaatatt tttaagacca gaaacagctc aaggaatatt 10381 tgttaatttt aaaaacgcta ttagaactac caggagaaaa atgccttttg gaatggcaca 10441 aataggtaaa tcctttagaa atgaaataac tcctggaaac tttaccttta gaactagaga 10501 gtttgaacaa atggaattag agtttttctg taaaccagga acagatttag aatggtttga 10561 atattggaga gactattcat ggaacttttt attatcactt ggacttgcaa aagataattt 10621 aagaataaga gagcatgcaa aagaagagct agctttttat agtaaagcta ctgtagatat 10681 agaatattta ttcccatttg gatggggtga attatggggt atagcagata gaacagatta 10741 tgatctaaag caacatatga atcattcagg aaaagactta acttatttag atccagaaac 10801 taatgaaaaa tatcttcctt attgtataga gccatcacta ggagcagaca gagttgccct 10861 tgcattttta gttgatgcat atgatgaaga agaacttgat ggaggagata gtagaactgt 10921 tttaagattg cacccagcat tagcaccatt caaagcggct attcttccat taactaaaaa 10981 acttaaagat aaatcattag aagtttatag catgttgagt aaatacttta atgtggatta 11041 tgacgaagca ggaactatag gaaaaagata tagaagagaa gatgaaatag gaactcctta 11101 ttgtataact atagattatg atacattaga agataacact gtaactatta gagataggga 11161 ttctatggat caaataagaa taaatataga tgaattagta aaatatatat cagaaaaagt 11221 tgagttttag aatttataat aataaagaga ggagttaaga tatcttaact cctctcttta 11281 tttaaaaata cttaaaaaaa gaccggattt tttatccggt ataaataggg tttaatcatg 11341 gggatatgtt atatgttcaa ttaaaacttg gggaattata ttaatgtttc cttacggcac 11401 gtttattagt atatcatcat gttttataca atgcaatact cagaagtgaa gtctttaaat 11461 taaatatttt ctaataattt cgacataatt aaacagaatt tttttgaaag aagtagatat 11521 aaattttata aattcaatta gcttagagta taattttagt gagtaaaagt gttataatta 11581 tttataataa aaatgagcat ggagggaaaa atgaataagg actttaatga attcaaaaaa 11641 tttatataca ataagaaagt agctataata ggtttaggta ttagcaatat gccactagta 11701 gaatttcttt ctaatttggg ggctagagta actggctttg ataaaaaaaa tgaaaatgaa 11761 ttagaaaata atataaatga attaaaagct aagggagtca attttgaatt aggagaaaac 11821 tatttagata agctttcaaa ttttgatgtt gtttttagaa cgccatctat gaggacagat 11881 catcctattt taataaaagc taaatctgaa ggagcgtata taacttctga aatggaagaa 11941 tttataaaat attgtccagc aaaactgttt tgtataacag gaagtgatgg taaaactact 12001 acaactactt taatatataa tatattaaaa actgaaggat atactgtttg ggtaggcgga 12061 aatataggaa atcctttatt tactaaaatt gaagagataa aaaaagatga taaagtggtt 12121 ttagaattat caagtttcca actaatgtct ataaaagaac ctatagaagt agcacttgta 12181 acaaatgtat cgcctaatca tttagatatt cataaggata tggaagaata tattaaagct 12241 aaaaagaata tttttaaata tcaaagagaa aatgacctct tagtaattaa tgaagataat 12301 aaaataacta aatctatgga agaagaatgt agaggaagat tacttaaatt tagcatgaaa 12361 gaaaaattaa aagaaggatc attttattat aatgaagatt tgtatattaa tgaaaaaaaa 12421 gtgtgtaatg taagtgaagt aaaattgaag ggtatgcata atgtagaaaa tttattggct 12481 gctttttctt gtgttagtga agatagtagt atagatagta tgagagaggt agctaaaaac 12541 tttaacgggg tggagcatag attggaattt gttaaagaaa ttcaagaagt caaatatttt 12601 aatgattcca ttgcatcaag tccaactaga acattagcag cattacaatc ctttgataga 12661 cctgttattt taattgcagg aggatatgat aaaaagatat cttttgaggt tttagctaaa 12721 gaaggaattt ctcatataaa acatttaatc cttctgggag ataccaaata caaaatagaa 12781 gaagctttta aaaaggtaat gagagatagt agtgaagatt tgcctatttc tatttgtaat 12841 tctatagaag aagctataaa tatagctaaa gagaatggag aatccggaga tgtagtaact 12901 ttatctccag cttgtgctag ttttgatatg tttaaaaact ttgaagaaag gggaaataag 12961 tttaaaagca ttataaggaa tttgtaatta ttttatagtt tatggatata atactcctga 13021 agtcattaaa atcaggagta ttaattttgt ttatataaaa caactgaatc aagtgtatct 13081 ttatgcgaaa tatgtagaaa aagctaaaaa taagaattaa ataaaagata attctgtaga 13141 ataagatgtc aacaatacat aggtaaattc aaatgtgtta gaatgaaata cgttgttgag 13201 agaaaacaac gcagagattt aaaagcaaca tatttattga aacaaatatt caataaaaaa 13261 aagtgttgac aagtttaaaa aaaacttgta tactgtaaaa gtcgcttgag tgcgacagac 13321 aaataggtct ttgaaaatta aacagagaaa taagccagtc gattcttatt gagaatcaaa 13381 aaatagtaat tgagcaaggt tttatcaatt atatatagtt gataaagact aaacttttaa 13441 attgagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcttaaca catgcaagtc 13501 gagcgatgaa gcttccttcg ggaagtggat tagcggcgga cgggtgagta acacgtgggc 13561 aacctgcctc aaagagggga atagccctcc gaaaggagga ttaataccgc ataaagttaa 13621 ggtttcgcat gaaactttaa ccaaaggagt aatctgcttt gagatgggcc cgcgccccat 13681 tagctagttg gtaaggtaat ggcttaccaa ggcgacgatg ggtagccgac ctgagagggt 13741 gatcggccac attggaactg agacacggtc cagactccta cgggaggcag cagtggggaa 13801 tattgcgcaa tgggggaaac cctgacgcag caacgccgcg tgggtgatga aggttttcgg 13861 atcgtaaaac cctgttttct gggacgataa tgacggtacc agatgaggaa gccacggcta 13921 actacgtgcc agcagccgcg gtaatacgta ggtggcaagc gttgtccgga tttactgggc 13981 gtaaagggtg cgtaggcgga tgcttaagtg agatgtgaaa tacctaagct taacttaggg 14041 gctgcatttc aaactgggca tctagagtac aggagaggga aacggaattc ctagtgtagc 14101 ggtgaaatgc gtagagatta ggaagaacac cagtggcgaa ggcggtttcc tggactgtaa 14161 ctgacgctga ggcacgaaag cgtgggtagc aaacaggatt agataccctg gtagtccacg 14221 ccgtaaacga tgaatactag gtgtaggagg gtccaacctt ctgtgccgca gttaacacat 14281 taagtattcc gcctggggag tacggtcgca agactaaaac tcaaaggaat tgacgggggc 14341 ccgcacaagc agcggagcat gtggtttaat tcgaagcaac gcgaagaacc ttacctagac 14401 ttgacatacc ctgaattact cgtaactgag gaagtccctt cggggacagg gatacaggtg 14461 gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 14521 acccttatta ttagttgcta ccattaagtt gagcactcta atgagactgc ccgggtgaac 14581 cgggaggaag gtggggatga cgtcaaatca tcatgcccct tatgtctagg gctacacacg 14641 tgctacaatg gtcggtacag agagacgcaa gaccgcgagg tggagcaaat ctcaaaaacc 14701 gatcccagtt cggattgcag gctgaaactc gcctgcatga agccggagtt gctagtaatc 14761 gcaaatcaga atgttgcggt gaatacgttc ccgggccttg tacacaccgc ccgtcacacc 14821 atgagagttg gcaacacccg aagtccgtga ggtaaccgta aggagccagc ggccgaaggt 14881 ggggttaatg attggggtga agtcgtaaca aggtagccgt aggagaacct gcggctggat 14941 cacctccttt ctaaggagta aaatattggc ttatattctc tgtttaattt tgagagactt 15001 aatgtctttc aaatagttct ttgaaaattg cacagagtaa actaaggtaa attaaacctt 15061 taaattaata actattagtt taagaattaa aaatcactag aagcaagtag tacaaggaaa 15121 taagtgaagt gagcagcgga gtttagcgga agctaaatga gcagcacagc gaacttattg 15181 acgcagtaat acgaagctta tagagatttt acatgatcaa gctacaaagg gcatatggtg 15241 aatgccttgg caccagtagc cgatgaagga cgtgataagc tgcgataagc ttcgggtagg 15301 cgcaaatagc ctgtgatccg gagatttccg aatggggaaa cctgcatacc taacggtatg 15361 taccgtaaat tgaatacata gatttgcggg ggtatacccg gggaactgaa acatctaagt 15421 acccggagga agagaaagaa aaatcgattt tcttagtagc ggcgagcgaa aaggaaagag 15481 cccaaaccag aaatttattt ctggggttgt ggatagacca tcatgaagac agactttaat 15541 cgaagagagc tggaacgctc taccacagaa ggtaatagtc ctgtaggtaa aaaattatgt 15601 cttttaggtc taatccagag taccacgaga cacgtgaaac cttgtgggaa gcagggagga 15661 ccacctccca aggctaaata ctaactggtg accgatagtg aagcagtacc gtgagggaaa 15721 ggtgaaaaga accccgggag gggagtgaaa tagaacctga aaccgtatgc ttacaaacag 15781 tgggagcacg ttaatgtgtg accgcgtgct ttttgtagaa cgagccagcg agttacggta 15841 tgtagcaagg ttaagcactt aaggtgcgta gccgaaggga aaccgagtct gaatagggcg 15901 actagttgca tgccgtagac ccgaaaccga gtgacctatc catgggcagg ttgaagcgga 15961 agtaaaattc cgtggaggac cgaaccacgt tggtgttgaa aaaccatggg atgacctgtg 16021 gatagcggag aaattccaat cgaactcgga gatagctggt tctcctcgaa atagctttag 16081 ggctagcgtc tggttattga gtaatggagg tagagcactg aatgggctag gggctgacaa 16141 cagttactga accctatcaa actccgaatg ccatatactt ttatccaggc agtcagactg 16201 cgagtgataa gatccgtagt cgagagggaa acaacccaga ccatcagcta aggtcccaaa 16261 gtgtaagtta agtggaaaag gatgtgggat ttctaagaca actaggatgt tggcttagaa 16321 gcagccactc atttaaagag tgcgtaatag ctcactagtc aagagatcct gcgccgaaga 16381 tgtccggggc tcaaacttac caccgaagct atggattcaa tagaatggta gaggagcttc 16441 ctgtatgggt agaagtcgta tcgtaagaag cggtggactg tacaggagtg agtatgctgg 16501 catgagtagc gagaaataag tgagaatctt attggtcgaa aacctaaggt ttcctgagga 16561 aggttcgtcc gctcagggtt agtcgggacc taagcccagg ccgaaaggcg taggtgatgg 16621 acaatcggtt gatattccga taccgccaac tttcgtttga caaatggggt gacacagaag 16681 gataaggtat gcacactatt ggatgtgtgt ctaagcactt aggcgtgctt gattggcaaa 16741 tccgtcaagc taagctgagg tgttatgggg agcctatttt ggcgaagtgc ctgattccac 16801 actgtcaaga aaagcctcta tggagaatgt tggtgcccgt accgcaaacc gacacaggta 16861 ggtgaggaga gaatcctaag accatcggaa gaattgctgt taaggaacta ggcaaattga 16921 ccccgtaact tcgggagaag gggtgccatg gaaacatggc cgcagtgaat aggcccaagc 16981 aactgtttag caaaaacaca ggtctctgct aaagcgaaag ctgatgtata ggggctgacg 17041 cctgcccggt gctggaaggt taaagggatc cgttagcgta agcgaagcgg tgaacttaag 17101 ccccagtgaa cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt 17161 aagttccgac ccgcacgaat ggcgtaatga cttgggcact gtctcaacag caaatccggc 17221 gaaattgtag tgcaagtgaa gatgcttgct acccgcgata ggacggaaag accccgtaga 17281 gctttactgt agcttaacat tgaatttcgg tattgtctgt acaggatagg tgggagactt 17341 agaagcagga gcgtcagttt ctgtggagtc atccttggga taccaccctg atagtactga 17401 aattctaacc ggggaccatg aatctggtca cgggacattg ttaggtgggc agtttgactg 17461 gggcggtcgc ctcctaaaaa gtaacggagg cgcccaaagg ttccctcagc gcggtcggaa 17521 atcgcgcgta gagtgtaaag gcataaggga gcctgactgc gacacataca ggtggagcag 17581 ggacgaaagt cgggcttagt gatccggtgg ttcctcgtgg gagggccatc gctcaacgga 17641 taaaagctac ctcggggata acaggctgat ctcccccaag agtccacatc gacggggagg 17701 tttggcacct cgatgtcggc tcgtcgcatc ctggggctgg agtaggtccc aagggttggg 17761 ctgttcgccc attaaagcgg cacgcgagct gggttcagaa cgtcgtgaga cagttcggtc 17821 cctatccgtc gcgggcgtag gaaatttgaa gggagctgtc cttagtacga gaggaccggg 17881 atggactgac ctctggtgca ccagttgtca cgccagtggc acagctgggt agctaagtcg 17941 ggaagggata aacgctgaaa gcatctaagc gtgaagccca ccctaagatg agatttccca 18001 tgacgtaagt caataagatc ccttgaagaa cacaaggttg ataggtcaga ggtgtaagtg c //