LOCUS NC_003413:17 18042 bp DNA linear BCT 17-AUG-2011 DEFINITION Pyrococcus furiosus DSM 3638, complete genome. ACCESSION NC_003413 SOURCE Pyrococcus furiosus DSM 3638, complete genome. COMMENT locus start: 1820217; locus end: 1838258 FEATURES Location/Qualifiers source 1..18042 /organism="Pyrococcus furiosus DSM 3638, complete genome." gene 0..1817 /gene="" /locus_tag="" /db_xref="1820217..1822034" CDS 0..1817 /gene="" /locus_tag="" /product="anaerobic ribonucleoside triphosphate reductase" /translation="MEKVDIIHEYARWGSLDVLENANRYPGPSGFFAYVMEEALKSSL SLIPEVGLRAHFSGDIYIHKLPYSLYIPYCTGHSIARLLKRGLRTPTITSRPAKHFDT FVDHIANYLITLQHYFSGAQAFSSVEWYAGPFIRKENLDLRKVKQNIQRLVYNLNYPT RIGLQTPFTNFTVTLDAPKKMLEGDYAIYNGEEVAPLGEYEREAKMFILALTEVLREG DALGQPFTFPIPTLMVTADMIWNDPEVFEAIFTTAAKRGSFYWLNTNVVDPDASYAMC CRLNIDKREFTYTFSLDEDVEKLERQRFGGLWAMPDVTGSVNVTTVNLPRIALKSRDE DEFWEEYEKTLEIVRITTEWFRNRYVKLLSMYPHMYSMIRDYLEEFPSSHFNTIGILG LPEAAALYLNSPELWKEGNRRDWIEAARLMKRMVEFATEKAREWMKATRVPWNVEEVP GESAQAKLALKDMKDFPELKEYLDDPENPIYSTSIAPYYGPLELGDRIRIEEIVQGSF TGGVMMHIFLGEEPDPEALAELTKKLMKTKLVYWSYTPALTVCNSCKSSFTGLYTSCP KCGSHDVEVWSRIIGYYRPLKNWNPYRKKEFWRRKHYLA" gene 1827..2543 /gene="" /locus_tag="" /db_xref="1822044..1822760" CDS 1827..2543 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MLIGGWKAVSMVDIPGKVTFTLWLCGCNLRCPFCHNWKLAQGME CFKLEKEELIAEVEENSYLVDYFHVTGGEPLIQWREFQELLREVREYLPVSLNSNLTL VKPLEKIIDLVDHVATDLKAPPTELYGLPENVSLKLWQLFLKGLEIVSENSIPLELRI PVSKGFDIQEIMRWIEEGLEKIDTDFYVVLHPLVGPPITNPRNKEWCNNHCWADREIE LIKEKLEERGVKKVIVRKYS" gene complement(2527..3249) /gene="" /locus_tag="" /db_xref="1822744..1823466" CDS complement(2527..3249) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MRKISLLVLVVVSSIIVAGCIGGGTSTAEVPKEELYAKLENATT LGVLWNLELLNSTTREVLATSKGKAVIYPNLVLSYRESEGENWISKSVITWENNEGSL ILVMTINNTTQKYEDSKEFNVTIARKMAFPGGEIELLLLDNMEFNSTKVETKCDGECV LRIVKEDSKVLYDIQGVWKIEYIEGNVTFDSNTKEISKVEIVMETSQGFIEKIKYEFI KNNLDEAKAEIERIREELKNTS" gene 3403..5052 /gene="" /locus_tag="" /db_xref="1823620..1825269" CDS 3403..5052 /gene="" /locus_tag="" /product="thermosome, single subunit" /translation="MAQLAGQPILILPEGTQRYVGRDAQRMNILAARIVAETIRTTLG PKGMDKMLVDSLGDIVITNDGATILDEMDIQHPAAKMMVEVAKTQDKEAGDGTTTAVV IAGELLRKAEELLDQNIHPSIIIKGYTLAAQKAQEILENIAKEVKPDDEEILLKAAMT SITGKAAEEEREYLAKLAVEAVKLVAEKEDGKYKVDIDNIKLEKKEGGSVRDTQLIRG VVIDKEVVHPGMPKRVEKAKIALINDALEVKETETDAEIRITSPEQLQAFLEQEERML REMVEKIKEVGANVVFVQKGIDDLAQHYLAKYGIMAVRRVKKSDMEKLAKATGAKIVT NIRDLTPEDLGYAELVEERKVAGESMIFVEGCQNPKAVTILIRGGTEHVVDEVERALE DAIKVVKDILEDGKILAGGGAPEIELAIRLDEYAKEVGGKEQLAIEAFAEALKVIPRT LAENAGLDPIETLVKVIAAHKEKGPTIGVDVYEGEPADMLERGVIEPLRVKKQAIKSA SEAAIMILRIDDVIAASKLEKEKEKEGEKGGGSEDFSSDLD" gene 5195..6613 /gene="" /locus_tag="" /db_xref="1825412..1826830" CDS 5195..6613 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MIPRIMSTQHPDNYSIPFFASSPILEGEDEITEAFYAFSVLGAD EQMWDFEGKEVDEFVVKKLLERYPTFFKNNILGKDIRLTPRVPNPSVEKEEAKLLLET LQGIARSADYARIFYGDNIAPIFEVILPMTTSVEEIERVYWLYKKAVVWISREKIYDI TVREWIGDFFPEKINVIPLFETKSALIKAAKITEAYILNRKNDIEYQRVFFARSDPAM NYGLITAVTYVKRALYEVLKVEEELSIPIYPIIGVGGPPLRGGMRPDNVDAVVKEYPS VQTFTIQSSFKYDYPTKDVVKAVEKIKSTKRKLPIPVEIPPFLVNYEAEYQKQIRILA PYINSVAKRIPRRRKRKLHIGLFGYSRNVNGITLPRAITFTAALYSIGIPPELLALNS LTDSQLETISEYYINVYEDLEFAMRFFSPKVAEKVGLKELAERVKEFKPEQIPEYIEE AEIVFKGEGDVMKLAQLRGFLG" gene 6659..8053 /gene="" /locus_tag="" /db_xref="1826876..1828270" CDS 6659..8053 /gene="" /locus_tag="" /product="L-aspartate oxidase" /translation="MKVAVVGSGLAGLTAAMSLAKKGIEVTVFGPKPKESNSYLAQAG IAFPISDGDSIISHVTDTIRGGKYLNDVTVVWNVISKSTEAYHFLTSLGIEFTSRELE GGHSFPRIFTIKNETGKYIIPVLEKHAKEMGVNFIRKFAEEVAIHNKKIVGVFVEGEL LYFDAVIIASGGFSGLYKFTAGNPWNLGIPIGDLALKGVPLRDIEFIQFHPTGFIGKR TYLISEAVRGAGAKLVTGEGERFVNELETRDVVAREIYRKMLEGKGVFLDATGIEDFK RRFPYIYSFLRREGINPKRDLIPVTPVAHYTIGGISVDIFYRTPIKGLYAIGEAACNG FHGANRLASNSLLECIVSGIEVSRTVIREKPRGERKEAKYHGYEPGNVDEVRDIMWNH AGIIRREESLRLGLKKLEKVEADPRVKILAEAVLKCALAREESRGAHYREDYPYSREE FRRPSIFRVENCML" gene 8098..9009 /gene="" /locus_tag="" /db_xref="1828315..1829226" CDS 8098..9009 /gene="" /locus_tag="" /product="quinolinate synthetase" /translation="MEKVEELKKEIERLKKERNAIILAHNYQLPEVQDVADFVGDSLE LARKATKVDADVIVFAGVDFMAETAKILNPDKIVLIPNKRATCAMANMLKVKHILEAK KKYPNAPVVLYVNSTAETKAYADVTVTSANAVDIIRKLDSDVIIFGPDKNLAHYVAKV TGKTIIPIPPEGHCYVHKKFTIEDVERAKKLHPNAKLMVHPECNPEVQEHADIIVSTG GMIRRACEWDEWVVFTEREMVYRLSKLYPNKKFYPAKEDAVCVGMKAITLQHVYESLR DMKYEVTVPEEIAEKARKAIERMLEMS" gene 9019..9849 /gene="" /locus_tag="" /db_xref="1829236..1830066" CDS 9019..9849 /gene="" /locus_tag="" /product="nicotinate-nucleotide pyrophosphorylase" /translation="MEIPISYLLKFVEEDAPYGDITSEAVIPREMSAKGVIIAKQEGI IAGVDEARKLFEYFGVEVNVKKQDGEFVKKGDVIMEVKGNARAILLVERTALNIIGRM SGIATETRRLVDIVREVNPKVKIAGTRKSLLRLLDKKAIMIGGGEPHRFSLSDAILIK DNHLALVPLEEAIRRAKEFSVYKVVEVEVESLEDAIKAAKAGADVIMLDNMTPEEIER VIEELKKLGLREKVKIEISGGITPENIREYARLDVDVISLGYLTHSVKNFDVSLEIVG" gene complement(9827..10459) /gene="" /locus_tag="" /db_xref="1830044..1830676" CDS complement(9827..10459) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MYRIKDEWGEFLVRLARRAIEEYLRTGREIEPPKDIPPELWEKM GVFVTLNRHNVPPQAALRGCIGFPLPIYPLVKATIKAAIYAAVDDPRFPPVKLEEMNN IVVEVSVLTPPELIEGPPEERPKKIKVGRDGLIVEKGIYTGLLLPQVAVEWGWDEEEF LAETCWKAGLPPDCWLDEDTKVYKFTAEIFEEEYPRGPVKRKPLIPQSQD" gene complement(10452..11021) /gene="" /locus_tag="" /db_xref="1830669..1831238" CDS complement(10452..11021) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKLVNVDEVSNIFYGIRSTARYIQAVFPLEGIICEVEEMVFEDG EKTASGEFYSTPKELLVELFDIITRGDLPTSVLEDVLMAVSLGDLSPVDELKDILEGK EDEVESLKMVIAEIIKTRKREDVIIVEGKDIVDLLPYGNDIKLFLLESNEIRKVSKEV NVKELRNILGMDVEDVMDIINLIRVREDV" gene complement(11057..11134) /gene="" /locus_tag="" /db_xref="1831274..1831351" CDS complement(11057..11134) /gene="" /locus_tag="" /product="tRNA-Pro" /translation="GAVG*LGPSCGLREPATRVQIPAAP" gene complement(11174..11872) /gene="" /locus_tag="" /db_xref="1831391..1832089" CDS complement(11174..11872) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MPREKVVRVWDEREVVYSPKRWRILWEKREKALKIMELLKDFDP HVYGSVARGDVRRDSDIDIVIPYRVPSYLIELALGDLIQRRRIVMATPWHLIKGHIEI DEETTVTFFLVDPTDRELEFYKWGGMLDLWGVKTKQRVPGVNKKLILIIPTDKGHIER EVVGREAEVAKILGVSVDIVEERVKVLTRRDRIGRTGIYLDEEVPDWKSFEEFLKELA DRDPNIRRRVRESL" gene 11944..12756 /gene="" /locus_tag="" /db_xref="1832161..1832973" CDS 11944..12756 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKVIMTTKIDKASMNIREKLIENFGFTESNLTFDGNRVYEKEDI LILTTNEEMIYYDYLDKEIEKQTKIKPEVIVFASRHSSAKKLPSLTTHVTGNWGKAMY GGKDESFAIAFPSAMKLALLKMHELNDLGWTVCYEATHHGPSELEVPSLFIEIGSSEE EWVNDRAGEIIAETIMYVLKKREKFKVALGIGGGHYAPKQTKVALESDLAFSHILPKY AQPVKKEVILRALSRSTEEVEAIYVDWKGSRGETRQLAKELANELGLEFIKD" gene 12886..15876 /gene="" /locus_tag="" /db_xref="1833103..1836093" CDS 12886..15876 /gene="" /locus_tag="" /product="hypothetical protein" /translation="VVRRSIVFFVISLLLGGLVNPSIVQASTQDPYEEFWEILWREAR LVGEAESGNTTAINELIENSKAGAENAIIISTQTWQTLQELKSAGVKLYYTEDELKEM IEEIKAKGLPQETVQALKNEGWSDEEIEEFEQYLIEHADEVKGDFNMSKFLTDFSNAF IRIAFKYNSYEARALELKYWKDYQSKPGDTLITREIPPQIAREWISFYRAYLFEGIDE KLSTIERLKAKEVEVIKSNPKGRDGHVIIRNSNFSIVFNKFKRIPIIKCTYWWNAIKA YNLTLQVESILKAQKLGNSNPELNYLLNHKVVELARALTAECYGDGTTPIPKPIITIP KPPKDTDLPLNDQIAREALMVGESEGILVIKAVRVNPVEVTSEYATYQVEVEIEAQNN AVYDINVEFDGTSLEDTEKVGMLNKDEVKVIKSTVSGKVYGSGSVTVAGTVKITYKSY RGNAPMAIQTTSMSKKTTERTYEETISLKDPVDPSKVSVTLSIDGDRVEGSALTFKAR VRNDNEVGISGSCTLSLEVPTSGTSRSSYQKSESFNAEGKSTALVNFGSVTYSRSGTY SYVLTCKFGQHSKSVDGEFTVRKKSSGSLGITTVTITPNLPRAGEIVTFKVEVKNSYS SGRNVSVKLFIDDVEVDSTSAYIPPDSTKTLTLQWSAEGGEHSYEIKLYNQGVKVEEK KGELNVSSVEYGLSGWLEVVPNPIEAGNNVSVIITVKNSENYKQTLPIELVDDTGNVW WPHEDYYGVNYSISNGYLTIYANKTARITATIGPLTQNTTLILKIGGRQMASEDVKVL GRVNWLELSRVSCNDLVLKVGGTLDYKGTATCVVELRNPTRSGVAIELDESRVLSIDF PMDHSNGVITLDTTTTIKAGETGNVYITFKAWTSDFTAFARYWLRGYYHLPVTIEFEL KMSRGNNFEYSKYEKYKISTQIQVKTSDTIYLAVSADIGSFFTGGEGLRGIVVAFKEG KRAKTVWEIFKVAQAFIRGILKKW" gene 15883..16422 /gene="" /locus_tag="" /db_xref="1836100..1836639" CDS 15883..16422 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MVGSVYTLFLYFSIILGVIVGVRTRSFHSSLAVLVFSSTFVAGI KYNNSYIAIISWLALSTLSSYLFHLNVIIKSRKDESVSNVLMGYLLGFFILLTLKLHG AGWILSILASYWVFYILLMFDYSKNRRAYYLLKTLWIIFSWGALIEAFGLQKELLPFL VVYTLIFILWFKRQEYSPT" gene 16500..17003 /gene="" /locus_tag="" /db_xref="1836717..1837220" CDS 16500..17003 /gene="" /locus_tag="" /product="hypothetical protein" /translation="VHFIYMERHYTLKEASKILGVTVKTLQNWDKQGKIRVIRTPGGR RSIPESEIKRILGIHEERKVVGYARVSSRTQKDDLKRQVQAIQQYAKEKGWNVEILKD ISSGLNEKRKNSSKWWQTRKCQSHHHTSRQTNKIWIQNTQNTLSSPWNRDNNNQRNSK RAKRRTH" gene 16822..17109 /gene="" /locus_tag="" /db_xref="1837039..1837326" CDS 16822..17109 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKRGKTPQNGGKQESVKVIITHPDRLTRFGFKTLKTLFQALGTE IIIINETQKELREELIEDLITIISHFAGKLYGMHSHKYKEVVENEKQLLQE" gene 17084..17218 /gene="" /locus_tag="" /db_xref="1837301..1837435" CDS 17084..17218 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKNNSSKNETIVKAYSIPLQPDKIILDFIEEYHKLAKITLEKNP" gene 17169..18041 /gene="" /locus_tag="" /db_xref="1837386..1838258" CDS 17169..18041 /gene="" /locus_tag="" /product="hypothetical protein" /translation="LKSITNWQKSLLKKILSTEKFTKVERKQLRDKLLKEWNYAAHYV DSAINQMLGLVKSYKRKLRRGKKVREPKLKKKFVYVKSTLFTLKGSVLRITIIPRKYY LEVNLANYPYLLPFLKELFEGKIKLGGLFLFPDKLVLNFVKTVEYFKPRDWMSVDINL TNVTVLANLTVYNFDTRELYHIHRVYEVKRQKIQKISAWNKKLSEKLLKKYSRRERNK SKDFLHKLANKIVEIARERGMGIILEDLNGIKENVLRGSKGLNRKLSKWNARELQRLI EYKAKWFGVPVCLC" ORIGIN 1 atggaaaagg tggacatcat ccacgagtat gcaaggtggg gaagtcttga cgttctggag 61 aacgcaaata gatacccagg acctagtgga ttctttgcct atgtaatgga agaagcacta 121 aaaagtagct taagcttaat tccagaggtc ggattaaggg ctcacttctc aggagatatt 181 tacatccaca agctccccta cagtctctac ataccttatt gtacagggca cagcattgct 241 agattactaa agagagggtt gaggacgcca acaataactt ctagaccagc taaacacttc 301 gacaccttcg ttgatcacat tgcaaactac ctaataaccc tacaacacta cttctctggt 361 gcacaggctt tctcaagcgt tgaatggtat gctggaccat tcataaggaa ggaaaatcta 421 gatctaagaa aagtaaagca aaatattcaa aggttagtct ataacctaaa ttacccaaca 481 agaattggcc ttcagacccc ctttacgaac tttacggtaa ctctcgatgc tccaaagaaa 541 atgcttgaag gagattacgc aatatacaat ggagaagaag tagctcctct aggtgaatat 601 gagagagagg ctaagatgtt catattggct cttaccgagg ttctcagaga aggagatgcc 661 ctaggacagc ctttcacgtt tccaatcccc acccttatgg taaccgcgga tatgatttgg 721 aatgaccccg aagtttttga agctatcttt accacagctg ctaaacgagg aagcttctac 781 tggttgaaca ccaacgttgt tgatccagat gcaagctatg caatgtgctg taggttaaac 841 atagataaga gagaattcac atatacattc tcgctagatg aagatgtaga gaagctcgaa 901 aggcaaagat ttggtggatt atgggcaatg cccgatgtta ctggttctgt aaacgttaca 961 acagttaacc ttcccaggat tgccctcaaa agcagagatg aagatgagtt ctgggaagaa 1021 tacgaaaaga ccctcgagat agttaggata acaaccgaat ggttcagaaa caggtatgtt 1081 aagttgctct ccatgtatcc ccacatgtac agcatgataa gggactactt agaggaattt 1141 ccatcaagcc acttcaacac catcggaatc ctgggacttc cagaagctgc cgcattatac 1201 ctaaactccc cagagttgtg gaaagaagga aatagaaggg attggatcga ggctgcaagg 1261 ttaatgaaga gaatggtgga gtttgctaca gaaaaggcca gagaatggat gaaagctaca 1321 agagttccat ggaatgttga agaagttcct ggggaaagcg cacaagctaa gttagctctc 1381 aaagatatga aggactttcc agagttaaag gaatacctag atgaccccga gaatcctatc 1441 tactcaacta gcatagcccc ctactacggc ccacttgaac taggagacag gattagaatt 1501 gaggaaatcg tccaaggaag cttcacggga ggggtaatga tgcatatctt cctgggagaa 1561 gagccagatc ctgaggcatt agctgagcta actaaaaagc taatgaagac caagctagta 1621 tactggagtt acactccagc tttaacggtc tgcaactcgt gtaaatcctc cttcacagga 1681 ttatatacga gttgccccaa gtgtggaagc cacgatgtag aggtatggag tagaataata 1741 ggctattata ggccattgaa gaactggaat ccatatagga agaaagagtt ctggagaagg 1801 aaacactact tagcctgagg tgtctctatg cttatcggag gatggaaggc agtaagcatg 1861 gtagacattc ctgggaaggt tacctttacc ctctggcttt gcggatgcaa tcttagatgt 1921 ccattttgcc acaactggaa gttagcccag ggaatggaat gctttaaact agagaaagag 1981 gagttaattg cagaagtcga ggaaaattca tacctagtgg attactttca tgtaacggga 2041 ggagaaccac taattcagtg gagggagttt caggaacttc tcagggaggt tagagagtat 2101 cttccagtaa gtcttaactc aaacctaaca ttagtgaaac cgttggagaa gataattgac 2161 cttgtggatc atgtggccac ggatctaaaa gctccaccaa ctgaacttta tggcttacca 2221 gaaaatgttt ccctcaagct ctggcaacta tttttgaagg gcttagaaat agtctccgaa 2281 aattccatac ctctagagct tagaataccc gtaagcaagg gatttgatat tcaagagata 2341 atgagatgga tcgaagaagg cctagaaaag atagacacag atttctatgt tgtgctacat 2401 cccttagtgg gacctcccat aacaaatccc aggaataaag agtggtgcaa caaccactgt 2461 tgggccgaca gagaaatcga attaataaaa gaaaagctag aagagagggg ggtaaagaaa 2521 gttatcgtca ggaagtattc ttaagctctt cccttattct ttctatttca gccttagctt 2581 catcgagatt gtttttgata aactcatatt taatcttctc aatgaacccc tgggaagtct 2641 ccataacaat ttcaaccttt gaaatttctt tcgtgtttga atcaaaggta acgttccctt 2701 caatgtactc aatcttccat acaccttgga tgtcgtatag aaccttgctg tcctctttaa 2761 ctatccttag cacgcattcc ccgtcacact ttgtctccac ttttgtagag ttaaattcca 2821 tgttatcaag taagagaagc tcaatttctc cccctggaaa agccattttc ctagctatgg 2881 taacgttgaa ttctttagaa tcttcatact tctgagttgt gttatttatc gtcattacga 2941 gaatcaaact accctcattg ttttcccatg ttatgacaga ctttgaaatc caattttctc 3001 cttcactttc cctataagac aggactagat taggatatat tactgccttg ccctttgaag 3061 ttgcgagaac ttctcttgtt gtagagttta aaagctctaa gttccacaaa actccaagcg 3121 ttgttgcatt ttccagcttt gcataaagtt cttcttttgg tacttctgcc gttgatgtgc 3181 ctcctccaat acatcctgcc acgataatgc tagaaacaac gaccaacaca agcaaggaaa 3241 ttttcctcat aaacttacac ctcttccctc tccaaccttt atactatata aggattgacc 3301 gaaaaattta taagcaatcc aaaggaacct ataagtggaa actacaacag gtaactaaaa 3361 cctgagaaag atataaaaca ataaataaag gaggtgtggg aaaatggccc agttagcagg 3421 ccaacccatt ctaattttgc ctgaaggaac ccaaagatac gttggtagag atgcccagag 3481 aatgaacatt cttgctgcta gaattgttgc agagacaata agaacaaccc tcggaccaaa 3541 gggaatggac aagatgctcg ttgatagcct tggagacatc gtaataacaa acgacggtgc 3601 aacaattctc gatgagatgg acattcagca cccagcagct aagatgatgg ttgaggtcgc 3661 aaagacccag gacaaggagg ccggtgatgg aacaacaacc gctgtagtaa ttgcaggtga 3721 gctcctaaga aaggctgaag aattactaga ccagaacatt cacccaagca taatcatcaa 3781 aggttacacc ttagcagcac aaaaggctca agagatcctc gagaacatag ccaaagaagt 3841 caagcccgac gatgaggaaa ttctcctcaa ggctgcaatg acatcaatta ccggtaaggc 3901 cgctgaggag gagagggagt acttagccaa gcttgcagta gaggcagtta agctagttgc 3961 agagaaggaa gacggaaagt acaaggttga catcgacaac atcaagctcg agaagaagga 4021 gggtggaagc gtcagagaca cccagctcat aagaggtgta gttattgaca aggaagtagt 4081 ccacccagga atgccaaaga gagtcgagaa agctaagatt gcactaatta acgatgcact 4141 tgaggttaag gagaccgaga ctgatgccga gataagaatt accagcccag agcaactcca 4201 ggccttcctc gagcaagagg agagaatgct cagagagatg gtcgagaaga tcaaggaagt 4261 cggagctaac gtagtattcg tccagaaggg aattgacgat ctagcacagc actacctagc 4321 caaatacgga ataatggccg tcagaagagt caagaagagc gacatggaga agctcgccaa 4381 ggccacagga gctaagatcg taaccaacat tagggacctc acaccagagg acctcggtta 4441 cgctgagcta gtagaagaga gaaaggttgc tggagagagc atgatattcg tcgagggctg 4501 ccagaacccc aaggctgtga caatcctcat cagaggtgga actgagcacg tagtcgatga 4561 ggtcgagaga gccctagaag atgcaataaa ggttgtgaag gacatccttg aagatggaaa 4621 gatcctagct ggcggtggag caccagaaat cgagttagcc attagactcg acgagtacgc 4681 caaggaagtt ggtggcaagg agcagttggc aattgaggcc tttgcagagg ctctcaaggt 4741 cattccaagg acactagcag agaacgctgg tctcgaccca atcgagacac tcgttaaggt 4801 catcgctgcc cacaaggaga agggaccaac catcggtgtc gatgtatacg aaggcgaacc 4861 agcagacatg ctagagagag gagtcatcga gccactaaga gtcaagaagc aagctatcaa 4921 gagtgctagc gaggcagcaa taatgatcct cagaatcgac gatgtcatcg ctgccagcaa 4981 gctcgagaaa gagaaggaga aagaaggtga gaagggagga ggaagcgagg acttcagcag 5041 tgatctagac tgatgtccca aacttttctc ccctttttct aattgtcttt tcttcaggag 5101 cattaacttc tagaatctta aattcttcgt cttttgttta aaacttcttc caatatcttt 5161 aaatatgact aattagctcg atcttggagg gcattatgat accaagaata atgagtactc 5221 aacatcctga caactattca ataccatttt tcgctagctc ccccatacta gagggagaag 5281 atgagataac ggaggcattc tatgccttca gtgtccttgg agcagatgaa caaatgtggg 5341 actttgaagg aaaagaagtt gatgaattcg ttgttaaaaa acttctcgag agatacccaa 5401 catttttcaa gaacaatatt cttggaaagg atattcgcct gaccccaaga gttccaaacc 5461 caagtgtaga aaaagaagaa gcaaagttac ttctcgaaac ccttcaagga atcgcaagaa 5521 gtgcggatta tgcaaggata ttctatggag ataacatagc tccaatattc gaagtaatac 5581 ttcccatgac aactagtgta gaggaaattg agagagtata ctggctctat aagaaggcag 5641 tagtttggat aagcagagag aaaatctatg atataacagt aagggagtgg atcggagatt 5701 tcttcccaga aaaaattaat gtaatcccac tgtttgagac gaaatccgct ctaatcaaag 5761 ctgcaaaaat aacagaagct tacatactaa ataggaagaa tgacattgag tatcagaggg 5821 tcttttttgc tagaagtgat cccgcaatga actacggtct aattacagca gtcacttacg 5881 ttaaaagggc actatatgaa gttctaaagg tagaagagga gctcagcatt ccaatatacc 5941 caattatcgg agttggtggt cctcccttga gaggaggaat gagaccagat aacgttgatg 6001 cagtagtaaa ggaatatcca agtgtccaaa ccttcacaat ccagagctcc ttcaagtatg 6061 actacccaac caaagacgtc gttaaggcgg tagagaaaat taaatcgaca aaaagaaagt 6121 tgccaattcc agttgaaatt cctccatttc tggttaacta tgaggcagaa taccaaaagc 6181 agattagaat tctagcccca tacataaaca gcgtagcaaa gagaataccc aggagaagaa 6241 agaggaagct ccacatagga ttattcggat attcaagaaa tgtgaacggg ataactctgc 6301 ccagagcaat cacattcact gctgcccttt actccatcgg aatcccccca gaacttcttg 6361 cattaaactc actcacagac tcccaactcg aaacaatttc agaatactac atcaacgtat 6421 atgaagactt agaatttgcc atgagatttt tctctccaaa agttgctgaa aaggtaggat 6481 tgaaagagct agcagaaagg gtcaaggaat tcaaaccaga gcaaatccct gagtacattg 6541 aggaggcaga aatagtgttt aaaggggaag gagatgtgat gaagctggcc cagttaagag 6601 ggtttcttgg ataaagccca tatacctcta cacttttttc tctgagaggg agaggaaaaa 6661 tgaaggtggc agtagttggg agtggcctcg caggtttaac cgctgcaatg tcattggcaa 6721 aaaagggaat tgaggttaca gtatttggcc caaaacccaa ggaatcaaat tcatatctag 6781 cccaggcggg gatagcgttt ccgataagtg atggagactc aattatttct catgtcacag 6841 acaccataag agggggaaaa tatctaaacg atgttaccgt tgtatggaat gtaatctcca 6901 agtcaacaga agcctatcac tttcttactt ccctgggaat cgagttcact agcagagagc 6961 ttgaaggggg ccattctttt cctagaatat tcacgattaa aaacgaaact ggaaagtaca 7021 taatccccgt attagaaaag cacgcaaaag aaatgggtgt gaatttcata agaaaatttg 7081 ctgaggaagt agcaattcat aacaaaaaga ttgttggagt ttttgttgag ggagagctac 7141 tttattttga tgcggtaata atagcttcag gaggattttc tggcttatac aaattcaccg 7201 ctggcaaccc ttggaactta ggaattccaa taggagattt agcactaaag ggagttccgt 7261 tgagggacat tgaattcatc caatttcacc caacaggttt catcggaaag agaacttacc 7321 taataagtga ggctgtgagg ggagctggag caaagcttgt aactggagaa ggcgaaaggt 7381 tcgtaaacga gctagagacg agagacgttg ttgctaggga gatatacaga aagatgctcg 7441 aaggtaaagg ggttttccta gatgccactg gaattgaaga ctttaagagg agattcccat 7501 acatatactc cttcctcaga agagaaggaa taaatccaaa aagagactta atccccgtaa 7561 ctcccgtggc ccactatacg attggcggga taagtgtaga tatattctac agaacaccca 7621 tcaagggatt gtacgccata ggagaggcag catgtaatgg attccatgga gcgaatagac 7681 tggctagtaa ttcacttcta gagtgcatag tttcgggaat agaggtctca agaacagtta 7741 ttagagagaa acccagggga gaaaggaaag aagccaagta ccacggatat gagccgggaa 7801 acgttgatga agttagagac ataatgtgga accatgcagg gataataaga agagaggaat 7861 ccttaaggct tggtctcaaa aaattagaaa aggttgaggc cgatccaaga gtaaagattc 7921 tggcagaagc tgtcttaaag tgtgccttag cgagagaaga aagtagagga gctcattaca 7981 gagaagacta tccctattca agagaggaat ttagaaggcc gagtattttc cgtgtagaaa 8041 attgcatgct ctaaaaaagt tattaagcac aattccctaa tcttcattgg ggattgttat 8101 ggaaaaggtt gaggagctta agaaggagat tgaaaggttg aaaaaagaga gaaacgcgat 8161 aatcctagcc cataactatc agctccctga agttcaggat gtagcagatt tcgttggaga 8221 cagtcttgag ctcgcgagga aggccacaaa agttgatgca gatgtaatag tttttgctgg 8281 agttgacttc atggcggaaa ctgccaaaat attaaacccg gataagatag ttctcatccc 8341 aaataagaga gctacatgtg caatggccaa catgcttaaa gttaagcata tactcgaagc 8401 taagaaaaag tatccaaatg ccccagtagt cctctacgtg aacagtacag ctgagaccaa 8461 ggcctatgca gacgtcaccg taacctcagc aaatgcagtt gatatcatta gaaagctcga 8521 ttctgacgta attatctttg gtccggacaa gaatttagct cactatgtgg ctaaggtcac 8581 tgggaaaacc ataatcccca tcccaccgga aggacactgc tacgtccaca agaagttcac 8641 aattgaagat gtcgagagag ccaaaaagct ccatcccaat gcaaagctta tggttcaccc 8701 cgaatgcaat ccagaagtcc aagagcatgc tgatataata gtctcaacgg ggggaatgat 8761 aagaagagca tgtgagtggg acgaatgggt tgttttcaca gagagggaaa tggtgtatag 8821 gctgagcaag ctctatccaa acaagaagtt ttatccagcc aaagaggatg cagtgtgcgt 8881 tggaatgaag gccataacac tgcaacatgt gtatgaatcc ctaagggata tgaaatatga 8941 agtcaccgtt ccagaggaga tagccgaaaa ggcaagaaaa gccattgaaa gaatgcttga 9001 gatgagttga ggtgtttcta tggagattcc aatttcatac ctcttaaaat ttgttgagga 9061 agatgctcct tacggagata taactagtga ggcagttatt cccagggaga tgagtgctaa 9121 aggggtaata atagcgaagc aagaggggat catagcggga gttgatgaag ccagaaagct 9181 cttcgagtac tttggagttg aagtcaatgt aaaaaagcaa gacggcgaat tcgtcaagaa 9241 gggagatgta ataatggaag ttaaaggaaa cgccagggct attctgctag tagagagaac 9301 cgccctcaac ataataggaa gaatgagcgg aattgccaca gaaactagga gactagttga 9361 cattgttaga gaagtaaatc caaaagtaaa gatagcggga actaggaaaa gtttgttgag 9421 gcttctagat aagaaggcca tcatgattgg aggaggggaa cctcacagat tttccctgag 9481 cgatgcaata cttatcaagg ataatcacct tgccctagtt cccctagaag aagcaataag 9541 aagggccaag gaattcagcg tatacaaagt ggtggaggtt gaagttgaaa gtctggagga 9601 tgcaataaaa gcggcaaaag cgggggccga cgtaataatg cttgataaca tgacgcccga 9661 agaaatagag agagttatag aggagctcaa gaagttggga ttaagggaaa aagttaagat 9721 tgaaatatcg ggagggataa ctccagaaaa tataagagag tacgcaagac tcgatgtgga 9781 tgttataagc ctcggctacc taactcattc cgtgaagaac ttcgatgtca gtcttgagat 9841 tgtgggatga gaggctttct cttaactggc cccctgggat actcctcctc aaatatctca 9901 gccgtaaact tgtacacttt tgtatcttca tcaagccagc agtctggtgg caatccagct 9961 ttccagcacg tctctgctag aaactcctcc tcatcccaac cccactccac tgccacttgg 10021 ggaagaagaa ggcccgtgta aattcccttt tccactataa gcccatccct tccaaccttt 10081 atcttcttag gcctctcctc cggtggaccc tcaataagtt ctggaggagt tagaacgctg 10141 acctctacaa cgatgttgtt catctcctca agcttcaccg gtggaaatct tggatcgtca 10201 acagctgcgt atatagcggc ttttattgtt gccttaacta gagggtagat cggcaagggg 10261 aaccctatgc atcccctcaa tgccgcttgt ggtggaacat tgtgcctgtt tagggtaaca 10321 aagactccca tcttttccca caactctgga gggatatctt tagggggctc tatctccctc 10381 cccgtcctga ggtattcctc tatagccctc cttgcgagcc ttactaggaa ctctccccac 10441 tcatccttaa tcctatacat cttccctcac ccgtatcaag tttattatat ccataacatc 10501 ctcaacatcc atcccaagga tatttcttaa ctcctttaca ttaacttctt ttgaaacttt 10561 ccttatctca ttactttcaa ggagaaagag ttttatatcg ttcccataag gcaaaagatc 10621 cactatatcc tttccttcaa ctatgatcac gtcttccctc tttctagttt tgataatttc 10681 tgctatcacc attttcaaac tttcaacttc atcttccttt ccttcaagga tgtccttcaa 10741 ctcatctaca ggagacaaat ctccaaggct tactgccatt agaacatctt ccaaaactga 10801 ggttggaaga tctcctctcg ttattatgtc aaagagttcc actaaaagtt ctttgggagt 10861 actgtaaaat tcgccacttg cagtcttttc tccgtcctca aaaaccatct cttcaacttc 10921 acaaattatt ccttcaaggg gaaacacagc ttggatgtac cttgcagtgg agcgaatacc 10981 ataaaagata tttgagactt cgtcaacgtt aacaagcttc atgaatcctc ccactgatat 11041 ctttacttta tatgtactgg tggggccgcc gggatttgaa cccgggtcgc gggctcccga 11101 agcccgcagg atgggccaag ctaccctacg gccccttcaa aatggacagg aatacataaa 11161 attataaact tttctcacaa gctctccctc accctccttc ttatgttagg atctctatca 11221 gccagctcct tcaagaattc ttcaaagctc ttccagtccg gaacttcctc atcaagataa 11281 attccagtcc tgccaattct gtcccttctt gtgagaacct taaccctctc ctccactata 11341 tctacgctaa ctccaagaat ctttgccact tctgcctccc ttccaaccac ctccctttcg 11401 atgtgtcctt tatcagttgg aattatcaga attaactttt tgttaacccc tgggactctc 11461 tgcttggtct tcactcccca caagtcaagc attcctcccc acttgtaaaa ctcaagctcc 11521 ctatcagttg gatcgactaa gaaaaacgtt acagttgttt cttcatcgat ctctatgtgc 11581 cccttaatta agtgccacgg agtagccatt actattcttc tcctctgaat taaatctccc 11641 aaggcgagct caattaaata gcttgggact ctataaggaa taactatgtc tatgtcacta 11701 tccctcctca catctcccct agctacgctc ccataaacat gaggatcaaa atccttgagg 11761 agctccatta tcttgagagc cttctccctc ttctcccaga gaatcctcca cctcttagga 11821 gagtaaacta cttccctctc atcccaaacc ctaacaacct tttccctggg catcaatatt 11881 actacttttt ccccatttaa taatgttttt aacgaagaaa gcttccttga atggggggag 11941 ataaatgaag gtaatcatga caactaagat tgacaaggct tcaatgaaca taagggagaa 12001 gctcattgaa aacttcggct ttacggagag caacctcaca ttcgatggga atagggttta 12061 tgagaaggaa gacatcctaa ttctcaccac aaacgaagag atgatatact acgactacct 12121 cgacaaggag attgaaaagc agacaaagat aaaacctgag gttatagttt tcgcatctag 12181 acactcaagt gcaaaaaaac ttccttccct aaccacccat gttactggaa actggggaaa 12241 ggcaatgtat gggggaaaag atgagagctt tgccatagca tttccaagcg cgatgaagtt 12301 agccctacta aaaatgcacg aactaaacga cctcggttgg acagtttgtt atgaagcaac 12361 tcaccacggt ccaagtgaac tggaagtccc tagcctcttc atagaaattg gatccagcga 12421 agaggagtgg gttaatgata gagctggaga aataatagcc gaaacaataa tgtatgtcct 12481 taaaaagagg gagaagttta aggtcgccct aggtattgga gggggacact atgctccaaa 12541 gcagacaaag gtagcacttg aaagtgacct tgcattctcc cacattctcc caaaatacgc 12601 acagccagtg aagaaggaag ttatccttcg cgcactttca aggtcgactg aggaagttga 12661 ggcaatatac gttgactgga agggaagtag gggagagact agacaactag ctaaggaatt 12721 agcaaatgag ctggggcttg aatttataaa ggattaattt catctgaata gtttatttct 12781 ttatgcgtgc tcaaagtaat aagtatgagt tcaattttat cactatgttt gttttttata 12841 tagaaatgtt ttttagtact attttgggtt gtaattttgg tgatttgtgg tgaggaggag 12901 tattgtattc tttgttataa gtttgttatt gggaggccta gttaatccta gtattgtcca 12961 agctagtact caggatccct atgaagagtt ttgggaaata ctttggaggg aggctaggct 13021 cgttggggag gcagaatctg gaaacactac agcaataaac gagttaatag agaactccaa 13081 ggctggggct gagaatgcca taataatctc aacccaaacc tggcaaaccc ttcaagaatt 13141 aaaatcagcg ggagtcaaat tgtactatac tgaagacgag cttaaggaaa tgattgagga 13201 gataaaggct aaaggcctcc cgcaagagac tgtacaagcc ttaaaaaacg aaggttggag 13261 tgatgaagaa atcgaggagt tcgagcagta cttgattgag catgctgatg aagtcaaggg 13321 cgactttaac atgagcaaat tcctaacaga cttctcaaac gcattcatta gaatagcatt 13381 caaatacaac agttacgagg cgagggcact agaactaaaa tactggaaag actaccaatc 13441 aaagcctgga gatactctaa taacccgcga aatcccacca caaattgcaa gagagtggat 13501 tagtttttac cgcgcttacc tctttgaagg aattgatgaa aaactctcca ccattgaaag 13561 gttaaaggct aaggaagttg aagtgataaa atcaaacccc aagggaaggg atgggcacgt 13621 cataataaga aattcaaact tttcaattgt ctttaacaaa tttaagagga ttccaatcat 13681 caaatgcacg tactggtgga atgcaatcaa agcctacaac ctaacactac aagttgagtc 13741 gatattaaaa gcccaaaagc tgggaaactc taacccagaa ttaaattacc tcctgaatca 13801 caaggtggta gaactggcga gggcattaac ggctgaatgt tatggggatg gaacaacacc 13861 aattccaaag ccaataatca caattccaaa accaccaaaa gatacggatc tgccattaaa 13921 tgatcaaatt gcccgggagg ctttaatggt tggggagagt gaggggattc ttgtaattaa 13981 ggcagtccgc gtgaatccag ttgaagtcac gagtgagtac gccacttatc aagttgaggt 14041 ggagattgag gctcagaata atgcagttta cgacattaac gttgagtttg atggaacatc 14101 actcgaggac actgaaaaag ttggcatgct gaataaggat gaggtaaagg tgattaagag 14161 tactgtcagt gggaaggttt acgggagtgg tagtgttacc gttgctggaa cagtaaaaat 14221 cacttacaag tcttaccggg ggaatgctcc aatggccatt caaacaactt caatgagtaa 14281 aaagaccact gagagaactt atgaagagac aataagcttg aaagatccag tggatcctag 14341 caaggttagc gtcacacttt ccattgatgg ggatcgtgtg gagggtagtg ccttaacctt 14401 caaggctcgc gtgaggaatg ataatgaggt tgggattagt gggtcttgta cactcagcct 14461 tgaagtccca acttcaggca cgagtaggag ttcttaccag aagtctgaaa gctttaacgc 14521 tgagggtaag agtactgctt tagtcaattt tggctcggtt acatactctc gctctggaac 14581 ttacagttac gtgctaactt gtaagtttgg acagcattct aagagtgtag atggcgagtt 14641 cactgtaagg aaaaagtcta gtggctcgct aggcattact actgtaacga taactccaaa 14701 cttgcccagg gctggggaaa ttgttacatt caaggttgag gttaagaatt cctactctag 14761 cgggaggaac gttagcgtaa agttgttcat tgatgatgtt gaggttgact ctactagtgc 14821 ttacattccc ccagactcta ctaaaaccct aaccctccag tggagtgctg agggtggaga 14881 gcactcctat gaaattaaac tctacaatca gggagtaaaa gttgaagaaa agaaaggaga 14941 actgaacgtt tcttcggtag agtatgggct ttctggttgg cttgaggttg ttccaaaccc 15001 gattgaagcg ggtaataatg tgagtgttat cattactgtg aagaattcag agaattacaa 15061 gcaaacattg cctatcgagt tagttgatga tactgggaac gtttggtggc ctcatgagga 15121 ttattacggt gttaattatt caatctcgaa tgggtatttg acaatctacg ccaacaagac 15181 tgcaagaata actgcaacca taggaccctt aactcaaaac acgaccttaa tactaaaaat 15241 aggcgggcgc caaatggcaa gtgaggatgt taaagtcttg ggaagggtta attggttaga 15301 gttgtcgaga gtgtcttgta atgatttggt tttgaaggtt ggtggaactc ttgactacaa 15361 gggtacggca acgtgtgtag ttgagcttag aaatccaact cggagtgggg ttgccatcga 15421 gttagacgaa tcgagagtcc tctcaataga cttcccaatg gatcattcta atggggtgat 15481 aactctggat actactacaa cgatcaaagc tggggagact ggaaatgttt atattacctt 15541 taaagcttgg acttcagact tcacggcatt tgcacgctac tggcttcgtg gttattatca 15601 cctgccagta acaattgaat tcgagttgaa aatgtcaagg ggtaataatt tcgaatactc 15661 aaaatacgag aagtacaaaa tctcaactca aatccaagta aaaacaagcg acacaatcta 15721 ccttgcagtt tcagcagaca tcggatcatt ctttacaggt ggagaaggat taaggggaat 15781 tgtagtagca tttaaagaag gaaaacgagc aaaaactgtt tgggagatat ttaaggtagc 15841 acaggcattt ataagaggaa tactaaagaa gtggtgagtc aaaatggtgg ggagtgttta 15901 tactctgttt ctttattttt ccattattct tggagtgatt gtaggagtta gaacaaggtc 15961 tttccattcc tccttggcgg ttttagtatt ttcctcaacc tttgttgcgg gaattaagta 16021 taacaattca tacattgcaa tcatctcgtg gcttgctcta tctacattat cctcttactt 16081 attccacttg aacgtcataa taaagtccag gaaggatgag agtgttagca acgtgcttat 16141 ggggtacctc ctaggattct ttatattact taccctcaag cttcatggag caggatggat 16201 attatccatc ttggccagtt actgggtctt ctatatactc ctaatgtttg attatagcaa 16261 aaacagaaga gcttattatc ttcttaagac cctctggatc atcttctcct ggggagcgtt 16321 gattgaagcg tttggacttc agaaagaatt gttgcccttc cttgtagtgt atactttgat 16381 ttttatcctc tggttcaaga ggcaagagta cagccctaca taaagttttt gaaagttaaa 16441 accgtttcta attgtttttc tttttgtgta atttcatgga aaataatgga aagggtgagt 16501 gtgcacttta tatatatgga gaggcattat actttgaaag aggcatcaaa aatccttgga 16561 gttactgtaa aaacacttca gaattgggac aaacagggaa aaatcagagt tatcagaaca 16621 cctggtgggc gaagaagcat tccagaaagt gaaataaaga ggatactcgg aatccacgag 16681 gagagaaaag tggttggtta tgcaagagtc tcaagtagaa cacaaaaaga tgacttgaag 16741 aggcaagtac aggcaatcca acagtatgcg aaagaaaaag gctggaatgt tgaaatcctc 16801 aaggacatta gttcgggatt gaatgaaaag aggaaaaact cctcaaaatg gtggcaaaca 16861 agaaagtgtc aaagtcatca tcacacatcc cgacagacta acaagatttg gattcaaaac 16921 actcaaaaca ctctttcaag cccttggaac agagataata ataatcaacg aaactcaaaa 16981 agagctaaga gaagaactca ttgaagactt gataacaatc atctcgcact ttgctggtaa 17041 attatatgga atgcattccc acaagtacaa agaggttgta gagaatgaaa aacaactcct 17101 ccaagaatga aaccatcgtc aaggcatact caatcccact ccaacctgat aagattatcc 17161 tagactttat tgaagagtat cacaaactgg caaaaatcac tcttgaaaaa aatccttagt 17221 actgaaaaat tcacgaaagt cgagaggaag caactccgag acaaactcct caaagagtgg 17281 aattatgccg cccactacgt tgactccgca ataaaccaaa tgcttgggct tgtaaagtcc 17341 tacaagcgga aactcaggag gggcaagaaa gttcgggaac caaagctgaa gaagaaattc 17401 gtttatgtaa aatccacact cttcaccctc aagggttcag tgctgaggat aacaataatc 17461 ccaagaaaat attatctaga ggtgaatctg gcaaattatc cttacctact cccattcctg 17521 aaggaattgt ttgagggaaa aataaaactc ggtggattgt ttttgtttcc agataaactc 17581 gttttgaact ttgtaaaaac tgtagagtac ttcaagccaa gggattggat gagtgtggac 17641 ataaacttga ccaacgttac cgttttggcc aatttaacag tttacaattt cgacactcgc 17701 gaactgtatc acattcaccg tgtttacgag gtaaaaagac agaaaatcca gaagatttca 17761 gcgtggaata aaaaactgag tgaaaaactc ttgaagaagt attcaaggag agagaggaat 17821 aagtcaaagg atttcctgca caagttggcc aacaagattg ttgagattgc gagggaaaga 17881 ggaatgggta taattctcga ggatttgaat ggtataaagg agaatgtctt gaggggttca 17941 aagggtttaa atagaaaact ctccaagtgg aatgctcgtg aattgcaaag gttgatagag 18001 tataaggcta agtggtttgg tgttcctgtt tgtttatgtt aa //