LOCUS NC_003098:1 18176 bp DNA linear BCT 03-OCT-2011 DEFINITION Streptococcus pneumoniae R6, complete genome. ACCESSION NC_003098 SOURCE Streptococcus pneumoniae R6, complete genome. COMMENT locus start: 586941; locus end: 605116 FEATURES Location/Qualifiers source 1..18176 /organism="Streptococcus pneumoniae R6, complete genome." gene 0..1112 /gene="msrA" /locus_tag="msrA" /db_xref="586941..588053" CDS 0..1112 /gene="msrA" /product="bifunctional methionine sulfoxide reductase A/B protein" /translation="MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQ GGKAVKKTEISKDADLHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYEL INQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAY PVIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEP LFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGP QDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD" gene 1362..2117 /gene="rr09" /locus_tag="rr09" /db_xref="588303..589058" CDS 1362..2117 /gene="rr09" /product="Response regulator" /translation="VVKEQSMTYTILIVEDEYLVRQGLTKLVNVAAYDMEIIGQAENG RQAWELIQKQVPDIILTDINMPHLNGIQLASLVRETYPQVHLVFLTGYDDFDYALSAV KLGVDDYLLKPFSRQDIEEMLGKIKQKLDKEEKEEQLQDLLTNRFEGNMAQKIQSHLA DSQFSLKSLASDLGFSPTYLSSLIKKELGLPFQDYLVRERVKQAKLLLLTTDLKIYEI AEKVGFEDMNYFTQRFKQIAGVTPRQFKKGEDR" gene 2114..3805 /gene="hk09" /locus_tag="hk09" /db_xref="589055..590746" CDS 2114..3805 /gene="hk09" /product="Histidine kinase" /translation="MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGN SQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENPSQDKVEGIRDLFLTILKSD KDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQH TVYSSSSKMEAMKPYIETGQGYTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQL LWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAKEVGAYELR EVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFH DSQRVVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINEN VAFDNLVLPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQD AGDSSQSQLKRGGVGLQNVDQRLKLHFGANYQMKIDSRPQKGTKVEIYINRIETS" gene 3900..4484 /gene="" /locus_tag="" /db_xref="590841..591425" CDS 3900..4484 /gene="" /product="hypothetical protein" /translation="VTTEVTEMNETQIQRETRQVVEDVLEKTNLKQGALFVLGLSSSE VLGGQIGKESSQEIGELIVETILGILGSRGIHLAVQGCEHVNRALVVERQVAEQFGLE IVSVHPTLHAGGSGQLAAFKFMQDPVEVEFIKAHAGLDIGDTAIGMHVKHVQVPIRPI LREIGHAHVTALTSRPKLIGGARAHYPQDAIRKF" gene 4506..10136 /gene="zmpB" /locus_tag="zmpB" /db_xref="591447..597077" CDS 4506..10136 /gene="zmpB" /product="Zinc metalloprotease" /translation="VFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEII SQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKK IASVFLVGTMGLVVLPSAGAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLD TVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEP KSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEES KVEQAGEPVAPRKDEQAPVEPENQPEAPEEEKAVEETPKQEESTPDTKAEETVEPKEE TKTAKGTQEEGKEGQAPVQEVNPEYKVTTGTVEKSTESELDFTTEVVPDDTKYVDEEV VERQGSKGVQVTKTTYETVEVVETDKVLSTTTEVKTPVVPKVVKKGTKPVETREEVIP FATKEQEDDTLKRGTRQVAQEGVNGKKQITETYKTIRGEKTNEAPTVEETVLQAPQDE IIKKGTKGLEKPTLQWANTEKDVLKKSATASYTLTKPAGVEIKSIKLALKDKDGQLVK EVTVAENNLNATLDKLKYYQGYTLSTTMVYDRGEGEETEKLEDKQIQLDLKKVEIKNI KETSLMNVDAEGNETDKSLLSEKPTDVSQLYLRVTTHDNKVTRLAVSSVEEVVVDGKT LYKVVAKAPDLVQRRADDTLSEEYVHYFEKQLPKVNNVYYNFNELVKDMQANPMGEFK LGADLNAVNVKPAGKAYVMAKFRGTLSSVENHQYTIHNLERPLFNEAEGATLKNFNLG NVNINMPWADKVAPIGNMFKKSTLENIKVVGSVTGNNDVTGAVNKLDEANMRNVAFIG KINSLGDKGWWSGGLVSESWRSNTDSVYFDGDIVGNNSKFGGLVAKVNHGSNQWDVKQ KGRLTNSVVKGTMTLKNHGQSGGLVHENYDWGWVENNISMMKVNNGEIMYGSGSIDGD PYFGFDYFKNNYYVKDVATGESTYKRSKQIQSISQAEADAKIANMGITANTFAIQDPV VNKLNRIIDRDSEYKAIQDYQETRNLAYRNLEKLQPFYNKEWIVNQGNKLTDESNLVK KTVLSVTGMKSGQFVTDLSSVDKIMIHYADGTKEEFGVSAISDSRVKQVKEYNVDDLG VVYTPNMVDKNRDSLITKVKEKLSSVALDSAEVKSITNNPASLYLEESFAEVRETLDK LVKSLLENEDHQLNSDEVAEKALLKKVEDNKAKIILALTYLNRYYGIDYDGLNFKHLM MFKPDFYGKTPSILDFLIRIGSAEKNLKGDRSLEAYREVIGGTIGKGELNGLLGYNMR LFTKYTDLNDWFIHAAKNVYVSEPETTTEDFKDKRHRIYDGLNNDVHGRMILPLLNLK KAHIFVISTYNTIAFSSFEKYGKNTEEERNAYKAEIDRVAKAQQRYLDFWSRLALPKV RNQLLKSQNSVPTPVWDNQVYVGLGGANRMGYGDGGRVVTPVRELFGPTDRWHQINWN MGAMAKIYERPWKDDQVYFMVTNMMEPFGISAFTHETTHVNDRMAYYGGDWHREGTDL EAFAQGMLQTPDKSTTNGEYGALGINMAYERKNDGEQLYNYDPEKLDSREKIDSYMKN YNESMMMLDYLEASAVIRQNLSDNSKWFKKMDKEWRTNADRNRLIGEPHQWDKLRDLT EEEKKLPIDSIDKLVENNFVTLHGMPKNGRYRTEGFDSSYQPVNMMAGVFGGNTSKST VGSISFKHNAFRMWGYYGYENGFIPYVSNKLKGAANKENKGLLGDDFIIKKVSKNQFQ NLEEWKKHWYHEVYDKAQKGFVEIEVDGVKISTYAQLQSLFEEAVSKDLAGMDDKNIK NHYQYTENLKWKIYKQLLKNTDGFSSDLFTAPQA" gene 10206..11927 /gene="pabB" /locus_tag="pabB" /db_xref="597147..598868" CDS 10206..11927 /gene="pabB" /product="Para-aminobenzoate synthetase" /translation="MHRKTVIDFRALGERYIFTKPIKELKTRNLTEVADLLAQVESYQ EQGYYVVGYVSYEAAPAFEEKLAVHKAPLLGEYLLYFTVHDRVETSPIPLTYDEVDLP SNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQDLSANPFAIYNRMVVEQEA GYNAYVEHDDMAVISMSPELFFEQNDRELTTRPMKGTTQRAITDQEDLEQASWLEQDS KNRSENMMIVDLLRNDMNRISEVGSEHVERLCQVEQYSTVWQMTSTIKSQLRADVDLV TIFRSLFPCGSITGAPKIATMEIIKDLEPQPRGVYCGTIGLLHPNGRRIFNVAIRTIQ LHQGEAIYGVGGGITWDSTWQSEYREVHQKAAVLYRKQARFQLITTGKISQKNLLFEE QHLERLRTASRYFAFPYDAEDLRQKIEAECQSCDIDQDYRLRISLSKSGEIELSRQIL TPLSLHFCQAKLCLQEANLQQAFTYFKTTYRPHLNLGEQEIIYHNKSGELLETSIGNL VLKIAGKLYTPPIRLGILPGIYRQYLLETGQVEEKVLTLTDFAQAEAIYGCNAVRGLY ELSLEEN" gene 12085..13074 /gene="" /locus_tag="" /db_xref="599026..600015" CDS 12085..13074 /gene="" /product="hypothetical protein" /translation="MNKRLFLKMSLVTLPILALFSQPVLAEENIHFSSCKEAWANGYS DIHEGEPGYSAKLDRDHDGVACELKNAPKGAFKAKQSTAIQINTSSATTSGWVKQDGA WYYFDGNGNLVKNAWQGSYYLKADGKMAQSEWIYDSSYQAWYYLKSDGSYAKNAWQGA YYLKSNGKMAQGEWVYDSSYQAWYYLKSDGSYARNAWQGNYYLKSDGKMAKGEWVYDA TYQAWYYLTSDGSYAYSTWQGNYYLKSDGKMAVNEWVDGGRYYVGADGVWKEGQASTA SSSNDSNSEYSAALGKAKSYNSLFHMSKKRMYRQLTSDFDKFSNDAAQYAIDH" gene 13192..14169 /gene="glcK" /locus_tag="glcK" /db_xref="600133..601110" CDS 13192..14169 /gene="glcK" /product="Glucose kinase" /translation="MKKENMMSQKIIGIDLGGTSIKFAILTTAGEIQGKWSIKTNILD EGSHIVDDMIESIQHRLDLLGLAAADFQGIGMGSPGVVDRDKGTVIGAYNLNWKTLQP IKQKIEKALGIPFFIDNDANVAALGERWMGAGDNQPDVVFMTLGTGVGGGIVAEGKLL HGVAGAAGELGHITVDFDQPISCTCGKKGCLETVASATGIVNLTRRYADEYEGDAALK RLIDNGEEVTAKTVFDLAKEGDDLALIVYRNFSRYLGIACANIGSILNPSTIVIGGGV SAAGEFLLQGVQKVYDENSFPQVRTSTKLALATLGNDAGVIGAASLVLQ" gene 14266..15105 /gene="thyA" /locus_tag="thyA" /db_xref="601207..602046" CDS 14266..15105 /gene="thyA" /product="thymidylate synthase" /translation="MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAF SEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDT GTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMF DVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNL HIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFD LAI" gene complement(15153..15323) /gene="" /locus_tag="" /db_xref="602094..602264" CDS complement(15153..15323) /gene="" /product="hypothetical protein" /translation="MAKGFAKGLVTGVAGTVAAVAGAVYAFKKKVIEPEEQKAAFIEE NRKKAARRRVSR" gene 15199..15387 /gene="" /locus_tag="" /db_xref="602140..602328" CDS 15199..15387 /gene="" /product="hypothetical protein" /translation="MKAAFCSSGSITFFLNAYTAPATAATVPATPVTRPLANPLAMSL PPLYSQSASLLKRSHFSD" gene 15393..16328 /gene="miaA" /locus_tag="miaA" /db_xref="602334..603269" CDS 15393..16328 /gene="miaA" /product="tRNA delta(2)-isopentenylpyrophosphate transferase" /translation="LCYNNSNEKMGIFQGKKMKTKIIVIVGPTAVGKTALAIEVAKRF NGEVVSGDSQQVYRGLDIGTAKASPEEQAAVPHHLIDVREITESYSAFDFVSEAKMTI EDIHSRGKLAIIAGGTGLYIQSLLEGYHLGGETPHEEILAYRASLEPYSDEELAHLVE QAGLEIPQFNRRRAMRALEIAHFGQDLENQEILYEPLIICLDDERSQLYERINHRVDL MFEAGLLDEAKWLFDHSPNVQAAKGIGYKELFPYFRGEQTFEEARESLKQATRRFAKR QLTWFRNRMQVTFYQIGESGVQDRILSQIEEFLDD" gene 16321..17559 /gene="" /locus_tag="" /db_xref="603262..604500" CDS 16321..17559 /gene="" /product="hypothetical protein" /translation="MIETEKKEERVLLIGVELQGMDSFDLSMEELASLAKTAGAVVVD SYRQKREKYDSKTFVGSGKLEEIALMVDAEEITTVIVNNRLTPRQNVNLEEVLGVKVI DRMQLILDIFAMRARSHEGKLQVHLAQLKYLLPRLVGQGIMLSRQAGGIGSRGPGESQ LELNRRSVRNQITDIERQLKVVEKNRATVREKRLESSTFKIGLIGYTNAGKSTIMNIL TSKTQYEADELFATLDATTKSIHLGGNLQVTLTDTVGFIQDLPTELVSSFKSTLEESK HVDLLVHVIDASNPYHEEHEKTVLSIMKDLDMEDIPHLTLYNKADLVEDFTPTQTPYT LISAKSEDSRENLQALLLDKIKEIFEAFTLRVPFSKSYKIHDLESVAILEERDYQEDG EVITGYISEKNKWRLEEFYD" gene 17552..18175 /gene="" /locus_tag="" /db_xref="604493..605116" CDS 17552..18175 /gene="" /product="hypothetical protein" /translation="MTDIKTLALKYGGYTSLDKVYLDQLLAGKTDQEQLTLITPPPSV VNAYFAELYQKKSPQAATDYFAELSQELNLYNTEPSFTLENKPFIRLNLSGKSFGFCY ESDGLGRIFFENEEKISDDLLFEIAQIFPHQLVFEESGKIYMKLVEDEEVISLESLTA LTDLERLADGRKRLKGYSQEDLLQEAAAFSGKRYFRSENRTAMLYID" ORIGIN 1 atgaatgata agttaaaaat cttcttgttg ctaggagtat tttttctagc cataaccggt 61 ttctatgttc tattgatacg aaatgcaggg cagacagatg cctcgcaaat tgaaaaggcg 121 gcagttagcc aaggaggaaa agcagtgaaa aaaacagaaa ttagtaaaga cgcagacttg 181 cacgaaattt atctagctgg aggttgtttc tggggagtgg aggaatattt ctcacgtgtt 241 cccggggtga cggatgccgt ttcaggctat gcaaatggta gaggagaaac aaccaagtac 301 gaattgatta accaaacagg tcatgcagaa accgtccatg tcacctatga tgccaagcaa 361 atttctctca aggaaatcct gcttcactat ttccgcatta tcaatccaac cagcaaaaat 421 aaacaaggaa atgatgtggg gacccagtac cgtactggtg tttattacac agatgacaag 481 gatttggaag tgattaacca agtctttgat gaggtggcta agaaatacga tcaacctcta 541 gcagttgaaa aggaaaactt gaagaatttt gtggtggctg aggattacca tcaagactat 601 ctcaagaaaa atccaaatgg ctactgccat atcaatgtta atcaggcggc ctatcctgtc 661 attgatgcca gcaaatatcc aaaaccaagt gatgaggaat tgaaaaagac cctgtcacct 721 gaggagtatg cagttaccca ggaaaatcaa acagaacgag ctttctcaaa ccgttactgg 781 gataaatttg aatccggtat ctatgtggat atagcaactg gggaacctct cttttcatca 841 aaagacaaat ttgagtctgg ttgtggctgg cctagtttta cccaacccat cagtccagat 901 gttgtcacct acaaggaaga taagtcctac aatatgacgc gtatggaagt gcggagccga 961 gtaggagatt ctcaccttgg gcatgtcttt acggatggtc cacaggacaa gggcggctta 1021 cgttactgta tcaatagcct ctctatccgc tttattccca aagaccaaat ggaagaaaaa 1081 ggctacgctt atttactaga ttatgttgat taatactctt cgaaaatctc ttcaaaccac 1141 gtcagcgtcg ccttaccgta tgtagggtta ctgacttcgt cagttttatc tacaacctca 1201 aagctatact ttgagctgac ttcgtcagtt ttatttacaa cctcaaagct atactttgag 1261 aaacctgtgg ctatcttcct agtttacttt ttgattttta ttgagtataa gaggtctttc 1321 ctaagcagtt agaggagaat tttgctatac tgatactagt aagtggtaaa ggagcagagc 1381 atgacctaca caatcttaat cgtagaagat gaatatctgg taagacaagg tttgactaaa 1441 ctggtcaatg tagcagccta cgatatggaa atcatcggtc aggctgaaaa tggaaggcag 1501 gcttgggaat tgatccaaaa gcaggtgcca gatatcattt taaccgatat caacatgcct 1561 catctaaatg gcatccagtt ggccagtctg gtacgagaaa cctatcctca ggttcatttg 1621 gtctttttaa caggttacga tgattttgat tatgccttgt ctgctgtcaa actaggtgtg 1681 gacgactacc tgctcaaacc cttttctcgt caggatattg aggaaatgtt ggggaaaatc 1741 aaacaaaaac tagacaagga agagaaagaa gagcagttac aagatttatt gactaatagg 1801 tttgaaggaa acatggccca gaaaatccag tctcatctgg ctgatagcca atttagttta 1861 aagtctttag ccagtgactt aggttttagt ccgacctatc tgagttcctt gattaagaaa 1921 gagttgggct tgccttttca ggattatctg gtgagagaac gtgttaaaca agccaagctc 1981 ttgcttttaa ctacagatct gaagatttat gagatcgcag agaaggttgg ttttgaagat 2041 atgaactatt ttacccaacg ttttaagcag attgcaggtg tgacacctcg tcagtttaag 2101 aagggagaag accgatgaag cgttcttctc ttttagttag aatggttatt tccatctttc 2161 tggtctttct cattctccta gctctggttg gaactttcta ctatcaatca agttcttcag 2221 ccattgaggc caccattgag ggcaacagcc aaacgaccat cagccagact agccacttta 2281 ttcagtctta tatcaaaaaa ctagaaacca cctcgactgg tttgacccag cagacggatg 2341 ttctggccta tgctgagaat cccagtcaag acaaggtcga gggaatccga gatttgtttt 2401 tgaccatctt gaagtcagat aaggacttga aaactgttgt gctggtgacc aaatctggtc 2461 aggtcatttc tacagatgac agtgtgcaga tgaaaacttc ctctgatatg atggctgagg 2521 attggtacca aaaggctatt catcagggag ctatgcctgt tttgactcca gctcgtaaat 2581 cagatagtca gtgggtcatt tctgtcactc aagaacttgt tgatgcaaag ggagccaatc 2641 ttggtgtgct tcgtttggat atttcttatg aaactctgga agcctatctc aatcaactcc 2701 agttggggca gcagggcttt gccttcatta tcaatgaaaa ccatgaattt gtctaccatc 2761 ctcaacacac agtttatagt tcgtctagca aaatggaggc tatgaaaccc tacatcgaga 2821 caggtcaggg ttatactcct ggtcacaaat cctacgtcag tcaagagaag attgcaggaa 2881 ctgattggac ggtacttggc gtgtcatcat tggaaaagtt agaccaggtt cggagtcagc 2941 tcttgtggac cttgcttggg gccagtgtca catctcttct tgtctgtctc tgcttagtgt 3001 ggttcagtct taaacgctgg attgctcctt tgaaggattt gagagaaacc atgttggaaa 3061 ttgcttctgg tgctcaaaat cttcgtgcca aggaagttgg tgcctatgaa ctgagagaag 3121 taactcgcca atttaatgcc atgttggatc agattgatca gttgatggta gctattcgta 3181 gccaggaaga aacgacccgt cagtaccaac ttcaagccct ttcgagccag attaatccac 3241 atttcctcta taacactttg gacaccatca tctggatggc tgaatttcat gatagtcagc 3301 gagtggtgca ggtgaccaag tccttggcaa cctatttccg cttggcgctc aatcaaggca 3361 aggacttgat ttgtctctct gacgaaatca atcatgtccg ccagtatctc tttatccaga 3421 aacaacgcta tggagataag ctggaatacg aaattaatga aaatgttgcc tttgataatt 3481 tagtcttacc caagctggtc ctacaacccc ttgtagaaaa tgctctttac catggcatta 3541 aggaaaagga aggtcagggc catattaaac tttctgtcca gaaacaggat tcgggattgg 3601 tcatccgtat tgaggatgat ggcgttggct tccaagatgc tggtgatagt agtcaaagtc 3661 aactcaaacg tgggggagtt ggtcttcaaa atgtcgatca acggctcaaa cttcattttg 3721 gagccaatta ccagatgaag attgattcta gaccccaaaa aggaacgaaa gttgaaatat 3781 atataaatag aatagaaact agctaactcc cagtcaattc tgggagtttt atgcgtaatt 3841 gggcaaactt tctaggttgt ctatcttgct aaaaacaaga aaaaacggta tgatagaaga 3901 gtgacaacag aggtaacaga gatgaacgag acacagattc aaagagaaac acgtcaggta 3961 gtggaagatg ttttagaaaa gaccaatttg aaacaggggg ccctttttgt tttaggtcta 4021 tcttctagtg aggtgctagg tggtcagatt gggaaagaat ccagtcaaga gattggtgag 4081 ctgatagtgg agactatctt gggtattcta ggtagtagag gtatccattt agcagttcaa 4141 ggttgtgagc atgtcaatcg ggctctcgtt gttgaacgtc aggtggcaga gcagtttggt 4201 ctggaaattg tcagtgtcca tcctactctt catgcaggag gttcggggca gttggcagcc 4261 tttaagttta tgcaggatcc agttgaggtt gaatttatca aggctcatgc tggattggat 4321 atcggagaca ctgcaattgg catgcatgtc aagcatgttc aggttccgat tcgccctatt 4381 ttgagagaga ttggtcatgc ccatgtaacg gcactgacta gtcgtccaaa attaatcgga 4441 ggtgcgcgtg cgcactatcc gcaagatgct attaggaagt tttgagaatg aataaaggag 4501 ataaaagtgt ttaaaaaaga ccgtttttca attcgtaaga ttaagggagt tgtaggctct 4561 gtatttcttg gaagcctttt gatggctcct tctgtagtgg acgcagccac ctatcactat 4621 gtaaataaag agattatttc acaagaagct aaagatttaa ttcagacagg aaagcctgac 4681 aggaatgaag ttgtatatgg tttggtgtat caaaaagatc agttgcctca aacagggaca 4741 gaagcatctg ttttgacagc ttttggtttg ctgactgttg ggagcttgct tttaatctac 4801 aagagaaaga aaattgctag cgtctttcta gttggaacta tgggattggt agttcttcct 4861 agtgcagggg ctgtagaccc agttgcgacc ctagcactgg ctagtcgaga gggtgttgtt 4921 gaaatggagg gctatcgcta tgttggttat ctatcaggtg acatcctcaa aacgcttggc 4981 ttggacactg ttttagaaga aacctcagca aaacctggag aggtgactgt agtcgaagtt 5041 gagactcctc aatcaacaac aaatcaggag caagctagga cagaaaacca agtagtagag 5101 acagaggaag ctccaaaaga agaagcacct aaaacagaag aaagtccaaa ggaagaacca 5161 aaatcggagg taaaacctac tgacgacacc cttcctaaag tagaagaggg gaaagaagat 5221 tcagcagaac cagctccagt tgaagaagta ggtggagaag ttgagtcaaa accagaggaa 5281 aaagtagcag ttaagccaga aagtcaacca tcagacaaac cagctgagga atcaaaagtt 5341 gaacaagcag gtgaaccagt cgcgccaaga aaagacgaac aggcaccagt cgagccagaa 5401 aatcaaccag aagctcctga agaagagaag gctgtagagg aaacaccgaa acaagaagag 5461 tcaactccag ataccaaggc tgaagaaact gtagaaccaa aagaggagac taaaacagct 5521 aaggggacgc aagaagaagg caaagaaggt caagcaccag tacaagaagt aaacccagaa 5581 tataaagtaa caacaggtac agttgagaag tctaccgaaa gtgaattaga tttcacaaca 5641 gaagtagttc cggatgacac aaaatatgta gatgaagaag ttgttgaacg tcaaggatct 5701 aaaggagttc aagttacgaa aacaacttac gaaacagtgg aagttgtaga gacagacaaa 5761 gtcctttcta caactacaga agtgaaaact cctgttgttc ctaaagtcgt taaaaaagga 5821 acaaaaccag ttgaaacaag agaagaagtc attccttttg ctacaaaaga acaagaagat 5881 gacactttaa aacgcggaac aagacaagta gctcaagaag gtgtaaacgg taagaaacaa 5941 attactgaaa cctataaaac aattcgcgga gaaaaaacaa acgaagctcc aacagtagaa 6001 gaaacagttc tccaagcacc tcaagatgag attatcaaaa aaggtacaaa agggttagaa 6061 aaaccaacac tacaatgggc taatactgaa aaagatgtct tgaagaagag tgctacagct 6121 agttatacat tgactaaacc agctggtgta gaaattaaat caattaaatt agcgctaaaa 6181 gataaagatg gacaacttgt taaagaagta acggtagctg aaaataattt aaatgctact 6241 ttagataaat tgaaatatta tcaaggttac accctatcta ctacaatggt ttatgatcgt 6301 ggagaaggtg aagaaactga gaaattagaa gataaacaaa ttcaattaga ccttaaaaaa 6361 gttgaaatca aaaacattaa agaaacaagc ttaatgaatg ttgatgctga gggtaacgaa 6421 actgataaga gcttattatc tgaaaaaccg acagatgttt cccaattgta tttacgtgtg 6481 acaactcatg acaacaaagt gacaagactt gcggtaagtt cagttgaaga agttgttgtt 6541 gatggaaaaa cattgtacaa agttgtagcc aaagctccag acttagttca acgtagagct 6601 gatgatacac tgagtgaaga atatgttcat tattttgaaa aacaattacc aaaagtaaat 6661 aatgtatact acaacttcaa tgaacttgta aaagatatgc aagctaatcc aatgggtgag 6721 tttaaacttg gtgcagattt gaatgcagtt aacgttaagc cagcaggtaa agcttatgtt 6781 atggctaaat ttagaggtac tttatcaagt gtagagaatc atcagtacac gattcataac 6841 ttagaaagac ctttgtttaa tgaggctgaa ggtgctacac tcaaaaactt taacttaggt 6901 aatgtaaata taaacatgcc ttgggctgat aaagttgcac ctattggtaa tatgtttaag 6961 aagtctacac ttgagaatat caaagtagtg ggttcagtaa caggaaataa cgatgtaacc 7021 ggtgctgtta ataagttaga cgaagctaat atgcgcaatg tagcttttat tggcaagatt 7081 aacagtcttg gagataaagg ctggtggtct ggtggacttg tcagcgaaag ttggcgaagt 7141 aacacggata gtgtttattt tgacggtgat attgtaggta acaattctaa gtttggtggt 7201 ttagtagcta aagtcaatca cggaagtaat cagtgggatg ttaaacaaaa aggtcgtttg 7261 acaaattctg ttgttaaagg tactatgact ctgaaaaatc atggtcaaag tggtggttta 7321 gttcacgaaa actatgactg gggttgggtt gagaataata ttagtatgat gaaagtcaat 7381 aacggtgaaa ttatgtatgg ttcaggttct attgacggtg acccatactt tggttttgac 7441 tacttcaaaa ataattatta tgtaaaagat gttgctactg gagaaagtac ctacaagcgt 7501 tcgaaacaga ttcagtctat ctctcaagcc gaagcagacg ccaaaatcgc taatatgggg 7561 attactgcga ataccttcgc tattcaagat ccagttgtaa acaagttaaa tcgtatcatt 7621 gatagagatt ctgaatataa agcgattcag gactaccaag aaacaagaaa cctagcttat 7681 cgaaacttgg aaaaacttca accgttctat aataaagagt ggattgtaaa ccaagggaat 7741 aagttaacag atgagtccaa tcttgttaag aaaaccgttc tgtctgtaac gggtatgaaa 7801 tcagggcaat ttgttactga tttatcaagt gtggataaaa tcatgattca ctatgccgat 7861 ggaaccaaag aagaatttgg ggtatctgcg atttcggact ctagggtaaa acaagtcaaa 7921 gaatataatg tagatgattt aggtgtagtt tacactccta atatggttga taagaacaga 7981 gattctttga ttacgaaagt taaagagaag ttgagttctg ttgctttaga ctctgctgag 8041 gttaaatcta ttacaaataa ccctgcatct ctatacctag aagaaagttt cgctgaggtt 8101 agagagacgt tagataagtt agtgaagtcc ttgttagaaa atgaagatca tcaactgaac 8161 agtgatgaag tggctgagaa ggcgcttctc aagaaagttg aagataataa agctaagatt 8221 atattagcct tgacttatct aaatcgttat tatggtatcg actatgatgg cttgaacttt 8281 aagcatttga tgatgtttaa accagacttt tatggtaaaa caccaagtat tttagatttc 8341 ttgattcgta taggttcagc agaaaagaat ttaaaaggag atagaagttt agaagcttat 8401 cgtgaagtta ttggtggtac tattggaaaa ggggaattaa atggcttgtt aggttataac 8461 atgcgtttat tcactaagta cactgactta aatgattggt ttattcatgc tgcaaagaac 8521 gtttatgttt ctgagcctga gacgactaca gaggatttca aagacaagcg ccatcgtatc 8581 tatgacggtt tgaataatga tgttcacggt cgtatgattt taccgttatt gaatttgaaa 8641 aaagcgcata tttttgtgat ttcgacttac aatacaatag cctttagttc ctttgaaaaa 8701 tatggtaaga atacagaaga agagcggaac gcttataaag ctgagattga tagggttgca 8761 aaagcacaac aacgttactt agacttctgg tctcgtttag ctttaccgaa agttcgcaat 8821 caacttttga agagtcaaaa ctctgtacca actcctgttt gggataatca agtttatgta 8881 ggtttaggtg gtgcaaaccg tatgggttac ggtgatgggg gtcgagtagt aactccagtt 8941 cgtgaattat tcggcccgac tgatcgttgg caccaaataa actggaatat gggagcgatg 9001 gcgaagattt atgaacgtcc ttggaaagat gatcaagttt atttcatggt tacaaatatg 9061 atggagccgt tcggtatctc agcctttacc catgaaacta ctcacgtcaa tgatagaatg 9121 gcttactacg gtggagattg gcaccgtgaa ggtacggatt tagaagcctt tgctcaaggc 9181 atgttgcaaa cacctgataa gtcaacaacc aatggtgaat acggtgctct cggtatcaat 9241 atggcttatg agcgtaaaaa tgatggtgaa cagctttaca attatgaccc tgagaagtta 9301 gatagtagag agaaaattga tagttacatg aagaactaca atgagtctat gatgatgctt 9361 gactacttag aagctagtgc agttattcgt caaaatttgt ctgataattc taagtggttc 9421 aagaagatgg ataaagagtg gcgcactaat gcagatagaa accgtttaat tggagaaccg 9481 catcagtggg ataaattacg tgatttaaca gaagaagaga agaagttacc tattgacagt 9541 attgacaagt tggtagagaa taactttgta actcttcatg gtatgccgaa gaacggtcgt 9601 taccgcacag aaggttttga tagctcttat caacctgtaa acatgatggc aggtgtcttt 9661 ggagggaata caagtaaaag caccgtaggg tctatttcat ttaaacataa tgctttccgt 9721 atgtggggat actatggata tgaaaatggc tttattcctt atgtttctaa caagttaaaa 9781 ggtgctgcaa ataaagagaa taaagggctt ttaggtgatg atttcattat caagaaagtt 9841 tctaagaatc aattccaaaa tctcgaagag tggaagaagc attggtatca tgaagtttat 9901 gataaagcac aaaaaggctt tgttgagatt gaggtagacg gagtgaaaat ttcaacgtat 9961 gctcagttac aatccttatt tgaagaagct gttagcaaag atcttgcagg tatggatgat 10021 aagaacatta agaatcatta ccaatataca gagaatctca agtggaaaat atacaaacaa 10081 ctccttaaaa acacagacgg tttctctagt gatctattta ctgcaccaca agcataggga 10141 tgaataaaat cgtaaaaagg tagatcagct ttgtctgtat ctgccttttt atgctatact 10201 taaggtatgc atagaaaaac agtgattgat tttagggctt tgggggagag atacatcttt 10261 accaagccga ttaaagagtt gaaaacgaga aatttaacag aagtggcaga tttgctggca 10321 caagtggaaa gctatcaaga gcaaggctat tatgtggtgg gttatgtcag ctacgaggct 10381 gcacctgctt ttgaggaaaa attagcagtt cataaggctc ctctactggg cgagtacttg 10441 ctttacttta ctgttcatga tagggtagaa acatccccta ttcctctgac ttatgatgag 10501 gttgatttgc cttcaaattg gcaggaagta acgtctgcag cagactatga aaaggctatt 10561 gcacagatac atcatcatct acggcagggt gatacctatc aggtcaacta caccgtccaa 10621 ctcaaacaag atttaagcgc caatcctttt gctatctaca atcgcatggt ggtagagcag 10681 gaggcgggct acaatgccta tgtggaacat gacgatatgg cagtaatttc catgagccca 10741 gagctctttt ttgagcaaaa tgaccgcgaa ttgacaacgc gaccaatgaa gggaacgact 10801 cagcgtgcca taactgacca agaagacttg gagcaggcca gttggttgga acaggattcc 10861 aaaaatcgct ctgaaaatat gatgattgtg gacctcttgc gcaatgatat gaatcgtatt 10921 tctgaggtgg ggagtgagca cgtggagcgt ctctgccaag tggagcagta ttcaactgtt 10981 tggcagatga cttcgactat caagagtcag ttacgagcag atgttgattt agttacaatt 11041 tttcgctctc tctttccttg tggatctata acgggagctc cgaaaattgc gactatggag 11101 attatcaagg acttggagcc acaaccgcgt ggagtctact gtggaacgat tggtctcttg 11161 catccaaatg gacgacggat ttttaatgtt gctatccgaa ctattcaact gcatcaaggg 11221 gaagccatct atggagttgg cggaggtatt acatgggata gcacctggca atctgaatac 11281 cgcgaggttc atcaaaaggc agctgttctc tatcgtaaac aagctcgttt ccagctgatt 11341 actactggaa aaatcagcca gaagaacttg ctgtttgaag aacaacattt ggaaagactg 11401 agaacagcta gtcgatattt tgcctttcct tatgatgcag aagacttaag acaaaagata 11461 gaggcggagt gtcagtcttg tgacattgat caagactatc gcttgcgaat ttctctcagt 11521 aagtctggag agatagaact tagtcgacaa atcttaacac ctcttagtct acatttttgt 11581 caggccaaac tttgtcttca ggaagccaat ttgcaacaag cctttaccta ttttaaaacg 11641 acttacagac cgcatttaaa cctaggggaa caagagatta tttaccacaa taagtcagga 11701 gaactgcttg aaacctctat cggaaatttg gttttgaaaa ttgctgggaa actctacaca 11761 ccgcctatca gacttggtat cttgccagga atttatcgcc agtatttact agaaacagga 11821 caagtagaag agaaagtctt gaccttgaca gattttgccc aagcagaagc tatttatggc 11881 tgtaatgcag tgagaggctt gtatgaatta agcctagagg aaaattagat gaaactggta 11941 tttttacacg gtttagggga gtcagcagag tcttggaaag aagttcggaa tcaattgaag 12001 gataagccca cagagactct tgaattgctg aaataagttt gataaaataa tattgaaatc 12061 gatatcataa ttatgggaga aagaaatgaa taaacgtcta tttttaaaaa tgagtctggt 12121 gacgttgcca attttagcct tgttttcaca accagttttg gcggaagaaa acatccattt 12181 ttcgagctgt aaggaagctt gggcgaatgg ctattcggat attcacgagg gggaacctgg 12241 ttattctgcc aagttagacc gtgatcatga tggtgtggct tgcgaattga aaaatgctcc 12301 taagggtgct tttaaagcaa aacagtcaac ggctattcaa atcaacacaa gttcagcaac 12361 aacaagtggt tgggttaagc aggacggcgc ttggtactac tttgatggaa atggaaatct 12421 agtgaaaaat gcatggcagg gaagctatta cctgaaagct gatggtaaaa tggcacagag 12481 tgaatggatt tatgactctt cttatcaagc ttggtattat ttgaaatcag atggttctta 12541 tgcaaaaaat gcatggcaag gagcttatta ccttaaatca aacggtaaaa tggcacaagg 12601 tgagtgggtt tatgattctt cttaccaagc atggtattac ttgaaatcag atggttcata 12661 tgctcgcaat gcatggcaag gaaactacta tttgaaatca gatggtaaaa tggctaaagg 12721 tgaatgggtt tatgatgcca cctatcaagc ttggtattat ttgacatcag atggttctta 12781 tgcttacagt acatggcaag gaaattacta tctaaaatcg gatggtaaaa tggctgtcaa 12841 tgaatgggtt gatggtggac gttattatgt tggcgctgac ggagtttgga aggaaggtca 12901 agcaagtaca gcttcttcta gtaatgatag caatagtgaa tattctgctg ctttaggaaa 12961 ggcaaaaagt tataattcgt tattccacat gtcaaaaaaa cgtatgtata gacaattaac 13021 ttctgatttt gataaatttt caaatgatgc agctcaatat gccattgatc attagatgat 13081 taacagatac tggtaggcga aaaaaattcc ttataattca cttacgcaaa cctttgcata 13141 agtgaatgaa ttttgatata ctagtactgt aagcattttc aattactaca caatgaaaaa 13201 ggagaatatg atgagtcaaa agattattgg gattgacctt ggtggaactt ctatcaaatt 13261 tgcaatctta acaacagcag gagaaatcca aggaaaatgg tcaatcaaga ccaacatttt 13321 ggatgaggga agtcatatcg ttgatgatat gattgagtct attcaacatc gtttggactt 13381 gcttggattg gcagcagcgg acttccaagg cattggaatg ggatcaccag gtgtggttga 13441 ccgtgacaaa gggactgtta tcggtgccta caacttgaac tggaaaaccc ttcaaccaat 13501 caaacaaaag attgaaaaag ctttgggcat tccatttttc atcgataatg atgccaacgt 13561 agcagctctt ggtgagcgct ggatgggtgc tggagataac caaccagacg ttgtctttat 13621 gacactcggt actggtgttg gtggcggtat cgtcgcagaa ggcaaattgc ttcacggtgt 13681 tgctggtgca gcaggtgagc ttggtcacat cactgttgac tttgaccagc caatctcatg 13741 tacttgtggt aaaaaaggct gccttgagac agttgcttca gcaacaggga ttgtcaactt 13801 gactcgtcgc tatgccgatg aatacgaagg cgatgcagcc ttgaaacgct tgattgataa 13861 cggagaagaa gtaactgcta agactgtctt tgatctcgca aaagaaggag acgaccttgc 13921 tttgattgtt taccgtaact tctcacgtta cttgggaatc gcttgtgcta acattggttc 13981 aatcctaaac ccatcaacaa tcgtcatcgg tggtggtgtg tcagctgcgg gagaattcct 14041 tctacaaggt gttcaaaaag tttacgatga aaatagtttc ccacaagtac gcacatctac 14101 taaattagct cttgcaactc taggaaatga cgctggagtt atcggagcag catcacttgt 14161 attgcaataa gataatgaga gaggaaaatg ctaacctaga gttagtaatg ttcctctttt 14221 attttttatg ctatactagt taggacaatg aatgaggtga aacgaaatga caaaagcaga 14281 tacgattttt aaagagaata ttgaacgcat tctaaaggaa ggtgttttct cagagcaggc 14341 tcgtcctaag tacaaggatg ggactgttgc taattccaag tatgtaactg gtgccttttc 14401 cgagtacgac ttatctaaag gagaatttcc tatcacaact ttgcgtccca ttgcaatcaa 14461 atccgccatc aaagaagttc tctggattta ccaagaccag tcaaatagct tagaagtgct 14521 taatgacaag tacaatgttc actactggaa tgactgggaa gttggagaca cgggaaccat 14581 tggtgagcgc tatggtgccg ttgttaagaa acacgacatt atcaataagc ttctcaaaca 14641 gttggaaacc aatccttgga accgccgcaa tattatttcg ctctgggatt accaagcttt 14701 cgaagaaaca gatgggctgc tcccgtgcgc ctttcagacc atgtttgatg ttcggcgtgt 14761 tgatggggaa atctatctgg atgcgacctt gacccagcgc tccaatgata tgctggtggc 14821 ccaccacatc aacgctatgc agtatgtggc tttgcagatg atgattgcca aacattttgg 14881 ctggaaggtt gggaagttct tctacttcat caacaacctc catatctatg ataatcaatt 14941 tgaacaagct caggaattgc tccgtcggga gccgtcaaac tgccaaccac gcttggtttt 15001 aaatgttcct gatgggacta atttctttga tatcaaagca gaagattttg agttggtgga 15061 ttatgaccct gttaagccac agttgaagtt tgacctagct atttaaaaga atagaaaaaa 15121 gaagttgaga ataatcccaa cttcttttgt ttcttaacgt gatacgcggc gacgagctgc 15181 ttttttacgg ttttcttcga tgaaagctgc tttttgctct tctggttcga ttactttctt 15241 tttaaatgcg tatactgcac ctgcaacggc agcgacagtt cctgcgacac ctgttacaag 15301 acctttagcg aatcctttag ccatgagtct tcctccttta tattctcaat cagccagcct 15361 cctcaagagg tcacattttt ctgactgacc tttttgtgtt ataataatag taacgaaaaa 15421 atgggaattt ttcaaggaaa aaagatgaaa acaaaaataa ttgtgattgt tggaccgact 15481 gctgttggaa agacggctct agctattgaa gttgcaaagc gctttaatgg cgaagtggtt 15541 agtggagata gccagcaagt ctatcgagga cttgatattg ggacggccaa ggctagtcca 15601 gaagagcagg cagctgttcc tcatcattta atcgatgtta gagagataac cgagtcttac 15661 tcggcttttg attttgtttc agaagctaag atgactattg aggatattca cagccgtggc 15721 aagctagcca ttatcgccgg tgggactgga ctttatatcc agagcttgct agaaggttac 15781 cacctaggtg gggagactcc tcatgaggag attttagctt atcgagctag tttggagcca 15841 tattcagatg aggaattagc ccatttggtg gagcaagcag gccttgagat tccccagttt 15901 aatcgtcgtc gtgctatgcg tgccttagaa attgcccatt ttggtcagga tttggaaaat 15961 caagagattt tgtatgaacc gctgattatc tgcttggatg atgaacgtag tcaactttat 16021 gagcgtatca accaccgagt ggatttgatg tttgaggctg ggcttttgga tgaggccaag 16081 tggctgtttg accattcccc taatgtacag gctgctaaag gaattggcta taaggaactc 16141 tttccttatt tccgtggaga gcagaccttt gaggaagctc gtgagagtct taaacaggcg 16201 acccgtcgtt ttgccaagcg tcagctgacc tggttccgta atcgcatgca ggtcaccttt 16261 tatcagattg gagaatctgg tgtacaagac cgcattttaa gccagataga ggagttttta 16321 gatgattgaa acggagaaaa aagaggagcg agtcctgctg attggtgtgg aattgcaggg 16381 tatggacagt tttgacctct ccatggaaga attggctagt ttagcgaaaa cggcaggggc 16441 agtcgttgta gatagctaca gacaaaaacg tgaaaaatat gattccaaga ccttcgtcgg 16501 ctctggtaag ttggaagaga ttgcgcttat ggtggatgca gaagaaatca ctactgtcat 16561 cgtcaacaac cgtctgaccc caaggcagaa tgtcaatcta gaggaagttc tcggtgttaa 16621 ggtcattgac cgtatgcagt tgattttgga tatctttgcc atgcgggctc gaagccatga 16681 agggaagctc caagtccacc tagcccaact caaatacctc ttgcctcgct tggttggtca 16741 ggggattatg ctcagccgtc aggcaggggg aattggttcc cgtggtcctg gtgaaagcca 16801 actggagctg aaccgtcgta gcgttcgcaa tcaaatcacg gatatcgagc gccagcttaa 16861 ggtggttgag aaaaatcgtg cgactgtcag agaaaaacgt ttggagtcta gcacttttaa 16921 gattggtttg attggttata ctaatgctgg gaaatcaact atcatgaaca tcttgaccag 16981 taagacccag tatgaagcag atgagctctt tgcgactctg gatgcgacaa ccaagagtat 17041 tcatctggga ggcaacctcc aagtaacttt gacagatacc gttggcttta tccaagattt 17101 gccgacagag ttggtgtcca gtttcaagtc aaccttggaa gaaagcaagc atgtggacct 17161 tctggttcat gttatcgatg ctagcaatcc ttaccacgag gagcatgaaa aaacggttct 17221 ctccatcatg aaagacctgg acatggaaga tattcctcac ttgacgcttt ataataaagc 17281 ggatttggtg gaggatttca cgcctaccca aacgccatat accctcattt ctgccaagtc 17341 tgaggacagt cgtgaaaact tgcaagcatt attgctagat aagattaagg aaatttttga 17401 agcatttacc ctgcgagtgc ctttttcaaa gtcctacaag attcatgatt tagagagtgt 17461 tgcaattctg gaagaacgtg attatcagga agacggcgaa gtgattacag gctacatttc 17521 cgagaaaaat aaatggaggt tagaagaatt ttatgactga tattaaaact ttggctctaa 17581 agtatggagg ttatacaagt ctggacaagg tctatctgga tcagcttcta gctggtaaaa 17641 cagatcagga gcagttaaca cttattacac ctccgccaag tgttgttaat gcctactttg 17701 cagaactcta tcagaaaaag agtcctcagg ctgcgacgga ttattttgca gaactcagtc 17761 aggaactgaa tctttacaat actgagccaa gtttcactct agaaaataag ccttttattc 17821 ggcttaatct gtctggtaaa tcctttggtt tttgttatga gagtgacggc cttggtcgga 17881 ttttctttga aaatgaggag aaaatctcgg atgacttgct ctttgaaatt gcgcaaattt 17941 tcccccatca attagtcttt gaagagtctg gtaagattta catgaagctt gtcgaggacg 18001 aggaagttat cagcctagaa agtctcacag ctttgactga tttggaaaga ttggctgatg 18061 gtcgaaaacg tctcaaaggc tacagccaag aggatttatt gcaagaagct gctgcttttt 18121 ctggcaaacg ctatttccga tcggaaaacc gcacagccat gttatatatt gattaa //