LOCUS NC_003030:18 18844 bp DNA linear BCT 17-AUG-2011 DEFINITION Clostridium acetobutylicum ATCC 824, complete genome. ACCESSION NC_003030 SOURCE Clostridium acetobutylicum ATCC 824, complete genome. COMMENT locus start: 3301342; locus end: 3320185 FEATURES Location/Qualifiers source 1..18844 /organism="Clostridium acetobutylicum ATCC 824, complete genome." gene complement(0..431) /gene="" /locus_tag="" /db_xref="3301342..3301773" CDS complement(0..431) /gene="" /locus_tag="" /product="Predicted DNA-binding protein" /translation="MSRPTKFRKVDFFPKSTCFIPLGKPKCEVEEIALKIEELEAIRL KDIKELNQEECAAKMEVSRQTFQNIIDSARKKIAIALTEGNAIAIGGGNFKSKFCKFK CLDCRNTYEINCENDKHMCPSCGSNNIVCNKKTGSCENLCK" gene complement(582..938) /gene="" /locus_tag="" /db_xref="3301924..3302280" CDS complement(582..938) /gene="" /locus_tag="" /product="hypothetical protein" /translation="VKIAIPNNENMINQHFGKSKSFIITTLEDDKIVNAEKISSVELL HQHQGLADLLVKNGVDVVIVGGIGAGALTALRQKGFKVIRGASGIYTEVIKEYINGNL EDKNVVCNHHGEHSHQ" gene complement(1133..1792) /gene="" /locus_tag="" /db_xref="3302475..3303134" CDS complement(1133..1792) /gene="" /locus_tag="" /product="Predicted membrane protein" /translation="MTKKISTFTSLIFILVICIIGFIKFRTIFMNVLVIPAKIISNLR FRKLNIPNVLMYSGYYSLLSMIFSIIFCVCLVLLIIHLLSRAQGPNFYSYIIKMLIVM GISGAVIYSNFWTITKDKIYVSSPETLGSIIRYDYNDVSSIAISVDDEKGAGPVLKVD LIVNKNNLDLWQSVSVNENNKNKEVKDLIITLKTRFHTSVTVNKHGHTEYDKDINYLL N" gene complement(1984..3648) /gene="ilvB" /locus_tag="ilvB" /db_xref="3303326..3304990" CDS complement(1984..3648) /gene="ilvB" /locus_tag="ilvB" /product="Acetolactate synthase large subunit" /translation="VKYNGSRIILECLKEQGVDTIFGYPGGAVLNIFDALYSFSEIRC VLTSHEQGASHAADGYARATGKVGVCLATSGPGATNLVTGIATAYMDSVPMVAITGQV ATSLIGKDSFQEVDITDITMPITKHNFIVRKVEDLADTIRKAFYIAQSGRPGPVLIDI PKDVTGNECEYEPRKPEKIEKSSVRDAEVEGAIELLLESKRPVIIVGGGCNISEASKE LKILQEKLKCPVCSTMMGLGAFSGKDDMFTGMVGMHGTKASNKSICESDLVIAIGCRF SDRVTSNADTFAKNAKILHIDIDEAEVSKNIKADSFIIGDVEEVLKKVNEKLTAREGN EWTEYALGLLKKDKSKVLRINKCDSVNPVYVIKKLYELTDGEAIITTEVGQNQIWATQ GYIYTKPRSFITSGGLGTMGYGFGAAIGASVGKDKMTFDIAGDGSFRMNINELATVVR YKLPVKIIVLNNNVLGMVRQWQNLFYKKRYSSTTLERDTDFVKIAEGYGALGLRVDTN AGVESALKKAIDYDGPVVIDFTVGEDEMATPIVPPGADIENMVVLD" gene complement(3654..5312) /gene="ilvD" /locus_tag="ilvD" /db_xref="3304996..3306654" CDS complement(3654..5312) /gene="ilvD" /locus_tag="ilvD" /product="Dihydroxy-acid dehydratase" /translation="VNSDKAMKGVERAPHRSLFKALGFIDEEMDRPLIGIANSYSELI PGHMNLDKIVKAVKDGIRMAGGVPVEFGTIGVCDGISMNHKGMSYSLPSRQIIADSVE IVAKAHALDGLVLVPNCDKVVPGMLMAAGRVNIPSIVISGGPMLSGRTNGRVTDLNSV FEAVGAVSAGKMSLEELAELENTACPTCGSCSGMFTANSMNCLSEVLGLALPYNGTIP AVFSERLRLAKKAGMKIVELVQKDIRPSDILTEAAFMNAVAMDMALGGSTNSLLHLPA IAYECDVDINFDKINEISEKIPHVCKLSPAGFHHIEDLHMAGGIPAVVNGIIKKGLLN GECMTVTGKTLYENVKDAKIKNIDVIRIDNPYSETGGLSVLRGNLAPDGAIVKKAAVA PEMMQHTGPARVFNSEEEVSKAILGGKINPGDVVVIRYEGPKGGPGMKEMLSPTASLA GMGLDKSVALITDGRFSGATRGASIGHVSPEAAEGGPIGLVEEGDTIEIDIEKKTINL LVPEEKLKNRKPEKVEKPVKGYLNTYRQGVSSACTGAVFHSTKE" gene complement(5359..6432) /gene="leuB" /locus_tag="leuB" /db_xref="3306701..3307774" CDS complement(5359..6432) /gene="leuB" /locus_tag="leuB" /product="Isopropylmalate dehydrogenase" /translation="MKEYKVAVIPGDGIGVEIVGEALKVLEKVGAKYDTKFNFTEVKA GGCAIDEFGVPLPNETLEICKNSDAVLLGAVGGPKWDTLPGEKRPEKALMGLRGGLGL YANLRPAKVYDILKSASPLKEEIINKGVDLLVVRELTGGIYFGERGRDIQNGINSAYD TERYNVEEIKRIAHVAFKAALKRNKKVTSVDKANILESSRLWRETVTEVAKEYPEVEL NYLYVDNAAMQLVREPSQFDVIVTSNIFGDILTDEASMVTGSIGMLPSASLRNDTFGM YEPIHGSAPDIAGQDLANPLAQILSVAMMLEYSFNMTEAARDVEDAVEKVLNSGYRTG DIYTEGSKKVGTKEMGKLVLAEL" gene complement(6463..6954) /gene="leuD" /locus_tag="leuD" /db_xref="3307805..3308296" CDS complement(6463..6954) /gene="leuD" /locus_tag="leuD" /product="3-isopropylmalate dehydratase, small subunit" /translation="MKVNGDVLKYGDNIDTDVIIPARYLNTSVPEELAKHCMEDLDVD FLKKLKTGDIVVGGRNFGCGSSREHAPICIKAAGVSCVIAKSFARIFYRNSINIGFPI LECEEAVNDASTGDKLEVDFIEGIIKNVTLNKEYKAQPFPDFMLKIMKNEGLTNCVKK GLF" gene complement(6957..8225) /gene="leuC" /locus_tag="leuC" /db_xref="3308299..3309567" CDS complement(6957..8225) /gene="leuC" /locus_tag="leuC" /product="3-isopropylmalate dehydratase" /translation="MKKPMTMTQKILANHAGLDYVEAGQLITANLDLVLGNDVTTPVA VKAFKTMGTNKVFDKKKVAIVPDHFTPNKDIKSAEHCKMIRQFAKSKEIENYFEIGEM GIEHALIPEKGLAVPGDVIIGADSHTCTYGALGVFSTGVGSTDMAVGMATGKAWFKVP EAIKFVLKGKPAKWVSGKDIILHIIGMIGVDGALYKSMEYTGDGLEYLSMDDRFTIAN MAIEAGAKNGIFPVDEKTIEYMKGRSDRELKKFDADEDAEYSRVIEIDLSTLKPTVAF PHLPENTKTIDQVGEVNVDQVVIGSCTNGRMEDLRIAASILKGKKIKKGIRLIVFPGT QNIYLEAMEEGLVRTFIEAGGIVSTPTCGPCLGGHMGILAEGERAISTTNRNFVGRMG HPKSEVYLASPAVAAASAIAGKIVSPEEVL" gene complement(8170..9813) /gene="leuA" /locus_tag="leuA" /db_xref="3309512..3311155" CDS complement(8170..9813) /gene="leuA" /locus_tag="leuA" /product="2-isopropylmalate synthase" /translation="MGKEKKVYIFDSILRDGSQAQGVSFSVADKIKIVKKLDELGIDY IEAGNPSSNPKDREFFEEIRSLKLKHSKLCAFGSTRRAGAKAEEDEGIKKLVDSGVNV FSIFGKAWDFHVTDIIKTSIEENLNMIRDSIKYLVSLNKEVVFDAEHFFDGFKSNKEY AIEVLNTARLAGAKWIVLCDTNGGTMPNEVSDIVKYLVRDLNFDNLGVHFHDDSGMAV ANSVVAVHYGVNHVQGTFTGVGERCGNANLSNIIANLSLKMGYNTIKNDKLEYLTVAF RYICEACNMTPNERVAYVGNCAFSHKGGMHIDAVRKNPKSFEHIDPSRVGNSRRILVS EVSGRSTILPALKRINPKIDKDSPETKAVVKRIKDLEYLGYQFEGAEGSFELLMRKEL NVFRPSFELVEYKVIAERPYLSDLSATAIVKIMVNGKLETTAADGKGPVNALDKALRK ALGVFYKELANVYLTDYKVRVISGTKATSAKIRVLIESTDGVSTWTTVGVSYDIIEAS WLALVDSVEYKLIQCNKEENNNEKTDDYDTKNTCEPCRA" gene 10346..10531 /gene="" /locus_tag="" /db_xref="3311688..3311873" CDS 10346..10531 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKKYKKGLLTHIFFYSIVIISSKTMTEKSKQKYAFREWELVRTH KLKLLKITPELQAEIYM" gene complement(10777..11274) /gene="ilvN" /locus_tag="ilvN" /db_xref="3312119..3312616" CDS complement(10777..11274) /gene="ilvN" /locus_tag="ilvN" /product="Acetolactate synthase, small subunit" /translation="LRLYVLSVLVDNIPGVLTRVCGLFNRRGYNLESVTAGVTENDKI SRLTLIASVKDENEIDQIVKQIKKIEVVHKVVLLNRENSVCREIMLIKVNAEGVQRQE ILNTVSIFRASVVDVTTKTFTIEITGNSSKIEAFQKMLEPYGIIEVVSSGSIAIERGQ NSILS" gene complement(11494..12888) /gene="cysS" /locus_tag="cysS" /db_xref="3312836..3314230" CDS complement(11494..12888) /gene="cysS" /locus_tag="cysS" /product="cysteinyl-tRNA synthetase" /translation="MKIYNTMTRKKEEFVPVKPNEVQMYVCGPTVYNFFHIGNARTFI VFDTVRKYFEYRGYKVNFIQNFTDIDDKMIAKANNEGVSVKELGDRYIKEYYEDADGL NLERATCNPRATEYIGKIIDFVKGLQDEGYAYEIDGDVYFNTNAFKEYGKLSGQNLED RMAGATIAVDDRKKSPADFALWKSEKPGEPSWESPWGKGRPGWHIECSCMARDLLGDT IDIHAGAIDLIFPHHENEIAQSEARTGKPFSKYWMHAAYLNINNEKMSKSLNNFLTAR DILKEYDAEVIRLFLLSAHYRTPLNFTEESIEAAKTSLERLYNTINNLGSLLNNTAES NDDSEYLKALDSYREKFIEKMDDDFNTADGISVIFDLAKDINININGKSSKAAVEKAI SLMRELGKPLGILQKVEKHNLEDEIQNLIEQRQNARKNKDWALADKIRDDLKERGIVL EDTPEGIRWKFIDK" gene complement(12926..14638) /gene="proS" /locus_tag="proS" /db_xref="3314268..3315980" CDS complement(12926..14638) /gene="proS" /locus_tag="proS" /product="prolyl-tRNA synthetase" /translation="MKMSNMLMLTLRESPAEAEIESHKLMLRSGMIRKMASGVYNYMP LGLKALKKVENIIREEMNAAGAQEFLASALLPSELWKESGRWEVFGPEMFKLKDRNER EFCLGPTHEEVFTDFARSEIKSYKQLPVNLYQIQTKYRDERRPRFGMIRSREFVMKDA YSFDKDNEGLDVSYNKMYEAYTKIFKRCNVSCSAVAADSGAMGGSGSAEFMVKSEIGE DEIAFCTECNYAANIEKAPAVPEKADKEELGELKKVETPHAKTIEELVEFFGVDSKKF VKTIIYRAENKVVAVMVRGDREVNETKVKNAVGSVDVELADEKTVKKATGAEVGFAGP IGLDVDYLLIDNEVTYMYNFIVGANETGYHYANANYDRDFKGTVGDFRNAVEGEKCPK CGKPLTIARGIEVGHIFKLGTKYSEAMKAYFVDENGESKPLIMGCYGIGVNRTMSAVV EQHHDDNGIVWPLSVAPYEVIVVPAVFKSEEQMKEAEKLYTELKKIGVDALLDDRNER AGVKFKDADLIGIPMRITVGKKISEGKVEFKCRNSEEVEVIDLDKVIARVEEEFEKNN LALK" gene 15166..16869 /gene="" /locus_tag="" /db_xref="3316508..3318211" CDS 15166..16869 /gene="" /locus_tag="" /product="Oligopeptide ABC transporter, periplasmic binding component" /translation="LKRKFITVVIPSIIIASLLSSCTNTSNSTAAKATKVSSLKDQYI KASLPSKNPEKAKNRKDTFIAAISEPGGVFLPYFYDNGWDGNATDPIFPSLVSTDEKG NPIADLAEKWDISSDNLTYTYHLRKRLKFSDGSPLTSDDVAFTLTLLDDPSYSGSFDI STCYIKGSTDYKNGKATSISGIAVVDPLTIKITTEKINPLNLTRLGGQVLSKAYYGKD YKKGNLDYLKSLYSRPLGAGPYKLDKYIPGQEIRYTANENYYKGKPKIENFIFKVTSK DTNLQLFQTGEIDSDSFSTDKDTVDQLENLGFANIRISTVSDYGFVYMNNKKPYLKDK NVRQALIYGLDRQKIVDVAYKGYGEVANVPTSPLVLSYTTDGINSYKFNPEKAKKLLE DDGWRLNSNGIREKNGQKLKISYLTSKNTDQTIPIAKENYKALGIDFEPEIMDFNTLV EKLNKGDYDLAAVRTSGLVDPNDSVEEFSSKKTSENVSGYFNPKVDELISEGVNTLNV KKRKAIYKKLYKELSDDPPVILIDYRKGLKAWNSRIKGMENDNFAGVSSTNLSKLKIE N" gene 16962..17918 /gene="" /locus_tag="" /db_xref="3318304..3319260" CDS 16962..17918 /gene="" /locus_tag="" /product="Oligopeptide ABC transporter, permease component" /translation="MKKYILRRFLQMIPTLIGVSIIIFYLFSLMPGDYIDSNRNLTPQ RAHELRVLNGFDKPIIVRYLIWLRNILHGDFGFSLKYLEPVTTLINQYIWNSFIIAIV TLILTWSIALVIGIFSATKQYSFFDRVITLLVFASLSFPSFFIGLLMIKFFGVDLKIL PIGGMVETGSTTIGLSHILEVIRHMILPVGILTFLSIGSLTRYFRSSMLDVLKQDFIR TARANGLKERKIIFKHALKNAILPAITLLSFELPGLFSGAIITEQIFNWPGIGRIQLE ALSFRDYPVLMTFTMLLSFLTIFGNFCADILYAAADPRIRLE" gene 17935..18843 /gene="" /locus_tag="" /db_xref="3319277..3320185" CDS 17935..18843 /gene="" /locus_tag="" /product="Oligopeptide ABC transporter, permease component" /translation="VFLFKNKNIKTSNKSLSKQTLKRILKNKLAIMSIIFLISILIFN FLGPFFSPYSYNDIDVSLIKQPPSISHLLGTDDYGRDVLTRLMYAGRISLTVGLASMI LSLLLGSILGCLSGYYGGILDIILMRLSDILMSIPGLPLLIIIAALLSELKVPSDYRL YIVMLMLSFVGWPGLARMVRGQVLSLREQNFMKAADILGLSDKRKIFHHLLPNTFPLL IVVATLSTADGILSESSLSFLGLGVIPPTPSWGNMINAANNLIDFQKRSWLWIPPGLA IFLTVISINLLGDALRDALDPKMKGR" ORIGIN 1 ttacttacat agattttcac aagagcctgt ttttttatta cagacaatat tattagaacc 61 acaagacgga cacatatgct tatcattctc acaatttatt tcatatgtat ttctgcaatc 121 caagcactta aatttacaaa atttcgattt aaagtttccg cctcctatag caattgcatt 181 tccttctgtt aatgcaattg ctatcttttt tcttgcacta tctataatat tttgaaacgt 241 ctgccttgaa acttccattt tagcagcaca ttcttcttga tttaattctt taatatcttt 301 taatctaata gcctcaagct cttctatctt taaagctatt tcttcgactt cacatttagg 361 ttttcccaat ggaataaagc atgtgctctt aggaaaaaaa tccactttcc taaactttgt 421 tggccttgac attttatttc ctccccgcat ttttatttgc aatttcatat aacttctcat 481 taaactcaat tattttctaa gctataaaaa ggacttcagt ttattctata ttaaacaaaa 541 actccaaatg ctagcttata tccaacattt agagttccta aactattgat gactatgttc 601 accatgatga ttacatacta cattcttatc ctctaaatta ccattaatat attctttaat 661 aacctctgta tatattcccg atgctcctct tataacctta aagcccttct gccttaaagc 721 tgtgagggca cctgccccta taccccctac tataaccaca tctactccat ttttcacgag 781 taaatcagct aaaccttgat gttgatgtaa aagctctaca gaggatatct tttctgcatt 841 tactatctta tcatcttcta aggttgttat aataaaactt ttactctttc caaaatgctg 901 atttatcata ttttcattat taggtatcgc tattttcaca gcactcaccc tttctatgtt 961 taatctgtat aaaaaccaaa taaaattttt ggcatatgcc atttacatta tacaatatat 1021 aattttttct tacaaacatt cacatttatt aatttgcttc catttatccc ttaaaataaa 1081 aaatagagct gctacctaat agcaacccat aaattcttct cttttaataa ggattaattt 1141 aacaaatagt ttatatcttt atcatattca gtatgtccat gtttattaac tgttacagaa 1201 gtatgaaatc ttgtttttaa agtaataatt aaatctttca cttctttatt tttattattc 1261 tcattaacag aaacggattg ccaaagatct aggttattct tattcacaat taaatcaact 1321 tttagtactg gtccagcacc tttttcatca tctacactta tagctatact cgatacatca 1381 ttgtagtcat atctaatgat agaacctagg gtttcaggcg aactaacata tattttatct 1441 tttgtaatag tccaaaaatt actatatatt actgcaccac ttatgcccat tacaataagc 1501 atttttatta tataagaata aaaattcggt ccttgcgctc tactcaataa atgtataata 1561 agtaatacta aacatacgca aaaaataatt gaaaaaatca ttgataaaag agagtaatat 1621 cctgagtaca taagtacatt aggtatattt aactttctaa aacgtaaatt tgaaataatt 1681 ttggctggta tgactaatac attcataaag atagttctaa attttataaa acctattata 1741 caaatgacaa ggataaaaat aagtgaagtg aatgtagaaa ttttttttgt catattaaaa 1801 gctcctcatt agttaatttt acataataat attaattata aaatacttta ctcttttatt 1861 caatttgata tttaatttaa tttaaatttt tattcaattt gtgcctttat ttatgcttta 1921 agtttaaaat ttctataaaa aaatggttat acaacttaat atcattgcat aaccattttt 1981 atttttaatc aagtacaacc atattttcaa tatcagcccc agggggaact ataggcgttg 2041 ccatttcatc ctctccaacg gtaaagtcaa ttactactgg tccatcataa tctattgcct 2101 ttttaagagc tgactctact cctgcatttg tatcaactct taaaccaagg gcaccgtatc 2161 cttcagctat ttttacaaag tcagtgtctc tctcaagagt agtacttgaa tatcttttct 2221 tgtaaaataa attctgccac tgtcttacca tgccaagaac attattgttt aatacaatta 2281 tttttactgg caacttatat ctaacaactg ttgcaagctc atttatgttc attctaaagc 2341 ttccatcacc agcaatatca aatgtcattt tatctttccc aacgctagcc cctattgccg 2401 ctccaaatcc gtatcccatt gtgccaagtc cacctgaagt tataaaactt ctaggctttg 2461 tataaatata tccttgagtt gcccatatct ggttttgtcc cacttctgtt gttattattg 2521 cttctccatc tgtaagttca tataactttt ttattacata tacaggattt acagagtcac 2581 atttatttat cctaagtacc ttagatttat cttttttcag aagacctaga gcatattctg 2641 tccactcatt accttctctt gcagtaagct tctcatttac tttttttaga acctcttcta 2701 catccccaat aataaaacta tctgctttaa tatttttaga aacctctgct tcatcaatat 2761 caatatgaag tatttttgca tttttagcaa aggtatctgc attacttgta actctatcac 2821 taaatctaca tccaatagct ataactaaat cactttcgca tatagattta tttgatgcct 2881 ttgttccatg cattccaacc ataccagtaa acatatcgtc cttgccacta aatgccccaa 2941 gtcccatcat agttgaacaa acaggacatt taagcttttc ttgaagaatt ttaagctctt 3001 ttgatgcttc cgatatattg caaccgccac caacaattat aacaggcctc ttactttcta 3061 atagaagttc aatagcccct tctacctccg catcccttac agagcttttt tcaatttttt 3121 ctggcttcct aggttcgtac tcacattcat ttcccgttac gtctttagga atatctatta 3181 atacaggacc tggtctacca ctttgtgcta tataaaatgc tttccttata gtatcagcta 3241 aatcttcaac ttttcttact ataaaattat gcttagttat tggcatagtt atatctgtta 3301 tatcaacttc ttgaaaagaa tctttaccta ttaatgatgt agctacttgc cccgttatag 3361 ctaccatagg tactgaatcc atatacgctg ttgcaattcc agttacaaga tttgtagccc 3421 ctggtccaga ggtcgcaagg caaaccccaa cttttcctgt agcccttgca tatccatctg 3481 ctgcatgtga tgccccctgc tcatgagatg ttagtacaca tcttatttct gaaaatgaat 3541 ataaagcatc aaaaatattt aagactgctc ctcccggata tccaaaaata gtatctacac 3601 cttgttcttt caaacattca agtataattc tggaaccgtt atatttcact ctcatcactc 3661 ctttgtacta tgaaaaactg ctcctgtaca agcagatgat accccctgcc tatacgtatt 3721 taaatatccc ttcacaggtt tttcaacctt ttccggtttt ctgtttttta atttttcttc 3781 cggaacaagt aggtttatag ttttcttttc aatatctatt tcaattgtgt ctccctcttc 3841 aaccaaccct attggaccac cttctgccgc ttctggagat acatgtccaa tggatgctcc 3901 tcttgtagca cctgagaatc ttccatcagt tataagcgcc acactcttat caagtcccat 3961 tcctgcaagt gaagctgttg gcgaaagcat ttccttcatt cctggtccac ccttagggcc 4021 ctcatacctt atcacaacaa catcacctgg atttattttt ccaccaagta ttgccttaga 4081 aacttcctct tcactattaa ataccctagc cggaccagta tgctgcatca tttcgggtgc 4141 tactgctgcc tttttaacta tagcgccatc tggagctaaa tttcctctca atactgaaag 4201 tccacctgtc tcactataag gattatctat tcttattaca tcaatgtttt tgattttcgc 4261 atccttcaca ttctcataca aagttttacc tgtaactgtc atacactctc catttagaag 4321 tccttttttt ataattccat taacaacagc cggtattcca cctgccatat gcaagtcctc 4381 tatgtgatga aatcctgcag gacttaactt acacacatgc ggaatctttt cacttatctc 4441 atttatttta tcgaaattaa tatccacgtc acattcataa gctatagctg gtaaatgaag 4501 aagtgaatta gtagaacccc ctagtgccat atccattgcg actgcattca taaatgcagc 4561 ttctgtaagt atgtcacttg gtcttatgtc cttttgaacc aattcaacta ttttcatacc 4621 tgccttttta gcaagtctta atctttctga aaatacagct ggtatagttc cattgtaagg 4681 aagcgcaaga cctaaaacct cagaaagaca gttcattgaa tttgctgtaa acattccaga 4741 acaagaccca caagtagggc atgccgtatt ctcaagctca gctaattctt ctaaagacat 4801 ttttcccgct gaaactgctc caactgcttc gaatacagag tttagatctg tgacccttcc 4861 atttgttcta ccagaaagca ttggtcctcc acttattact attgaaggta tgttaactct 4921 tccagccgcc ataagcattc ctggaactac cttatcgcaa tttggcacaa gtacaagccc 4981 atcaagagca tgtgctttag ccacgatctc aacactatct gctataatct gtcttgatgg 5041 aagagaataa ctcattccct tatgattcat agaaatacca tcacaaactc caatggttcc 5101 aaattctaca ggaacacctc ctgccattct tattccatct tttacagcct taactatttt 5161 atcaagattc atatgacctg gtataagttc gctgtaagaa ttagctattc ctataagagg 5221 tctatccatt tcctcatcta taaaacctaa agccttaaaa agagatctgt ggggagctct 5281 ttctactcct ttcattgcct tatcagaatt cacataaatc actccttttc attttggtgg 5341 atttgactgt ttatacttat taaagttcag ctaaaacaag cttacccatt tcttttgttc 5401 caactttttt acttccttct gtgtatatat caccagttct gtatccacta tttaaaactt 5461 tttctactgc atcttctaca tctcttgcag cttcagtcat attaaatgaa tattcaagca 5521 tcattgcaac tgataatatt tgtgctaatg gatttgctaa atcttgtcct gcaatatctg 5581 gtgcagaacc gtgtattggc tcatacattc caaaagtatc atttctaaga cttgccgatg 5641 gcagcattcc tattgagcct gttaccattg aagcctcatc tgtaagaata tctccgaata 5701 tgttgctggt tactattaca tcaaattgtg atggttcacg tacaagctgc attgctgcat 5761 tatcaacgta aagatagttt aattcaacct ctggatattc ctttgcaacc tctgttactg 5821 tttctctcca aagccttgaa gattccaata tatttgcttt atctacagaa gtaaccttct 5881 tatttctctt aagagcagct ttaaaagcaa catgtgcaat tctctttatc tcttctacat 5941 tatatctttc agtatcataa gctgagttta ttccgttttg aatatctctt cctctttctc 6001 caaagtaaat tcctcctgta agctctctta caacaagtaa atctactccc ttgtttatga 6061 tttcttcctt taaaggagat gcagatttta aaatatcata aacctttgct ggtcttaagt 6121 tagcataaag tccaagtcca cctcttaaac ccataagagc cttttcaggt cttttttctc 6181 ccggaagagt atcccactta ggtcctccta ccgctcccaa aagtactgca tccgagtttt 6241 tacagatttc taaagtttcg tttggaagag gtactccaaa ttcatctata gcacatcctc 6301 ctgccttaac ctctgtaaaa ttaaacttag tatcgtattt cgctcctact ttttcaagaa 6361 ccttaagagc ttctcctact atttcaacac cgattccatc accaggtata acggccacct 6421 tatattcttt cattaataac cctccaaata aaaatgtatt taattaaaat aaacctttct 6481 ttacacagtt agtaagtccc tcatttttca tgattttaag catgaaatcc gggaaaggtt 6541 gagccttgta ctctttattc aaagttacat tcttgattat tccttctata aaatcaacct 6601 caagcttatc tcctgtgcta gcatcattaa cagcttcctc acattctagt attggaaaac 6661 ctatatttat ggaatttctg tagaatattc tagcaaagct ttttgctata acacaagaaa 6721 ctcctgccgc cttaatacat attggggcat gttctcttga agatccacat ccaaaatttc 6781 ttcctcctac tacaatgtca cctgttttta acttttttag aaaatccaca tctaaatctt 6841 ccatacagtg ttttgcaagc tcttcaggta ccgaagtatt taaatatctt gctgggatta 6901 taacatccgt atcaatatta tctccatatt ttaaaacatc tccattaact ttcataatta 6961 taaaacctcc tctggtgata ctatttttcc tgctattgct gaagctgctg ctaccgctgg 7021 acttgctaag taaacttcac tcttaggatg tcccattcta cccacaaagt ttctattagt 7081 tgtagatata gctctttctc cttctgcaag tattcccata tgacctccaa ggcaaggtcc 7141 acaagttggg gtacttacta ttccgccagc ttctataaat gttctaacta gtccttcttc 7201 catagcttca aggtatatgt tttgagttcc tgggaatact ataagtctta ttcccttctt 7261 aattttcttt ccttttaaga tcgaagctgc aattcttaag tcttccattc ttccattagt 7321 acatgaacca attactactt gatctacatt aacctctcca acctgatcta tagtttttgt 7381 attttcaggt aaatgtggaa atgcaactgt aggctttaat gtacttaaat ctatttctat 7441 aaccctgctg tattcagcat cttcgtctgc atcaaatttc tttaattctc tatcacttct 7501 acccttcatg tattcaatag tcttttcatc tacaggaaat attccattct tagctcctgc 7561 ttctattgcc atatttgcaa ttgtaaatct gtcatccatt gaaagatact ctagaccatc 7621 acctgtatac tccatcgatt tatataaagc tccgtcaaca ccaatcattc cgattatgtg 7681 gagtattata tctttaccag acacccattt tgctggcttc cctttaagaa caaattttat 7741 agcctctgga accttaaacc aagctttacc tgtagccatt ccaactgcca tatcagtact 7801 tccgacgcct gttgaaaaaa ctccgagtgc tccgtaggta caggtatgtg aatctgctcc 7861 tattattaca tctccaggaa cagcaagtcc tttctcaggg ataagtgcat gctcaattcc 7921 catttcacct atttcaaaat agttctctat ttctttactt ttagcaaatt gtcttatcat 7981 cttacagtgt tccgctgatt ttatatcctt gttaggtgtg aaatgatctg gtactatagc 8041 tactttcttc ttatcaaaca ccttgttagt tcccatagtt ttaaatgctt taacagctac 8101 tggtgtagtt acatcatttc ctaaaacaag atcaaggtta gctgttataa gttgtcctgc 8161 ctctacataa tcaagccctg catggttcgc aagtattttt tgtgtcatag tcatcggttt 8221 tttcattgtt attttcctcc ttattgcatt gtattaattt atattctact gaatctacaa 8281 gtgctagcca gctggcttct attatgtcat aggaaacacc aactgttgtc catgttgata 8341 caccatctgt agactcaatt aatactctta tttttgcact tgtagcctta gttccactga 8401 ttactcttac cttatagtct gtaagataaa catttgctaa ttctttgtag aacactccaa 8461 gtgcttttct taaagcttta tcaagtgcgt ttacaggtcc tttaccatct gctgcggttg 8521 tttcaagttt gccattaacc attattttaa ctattgctgt agcacttaag tcacttagat 8581 atggcctttc agcaattacc ttatactcta caagttcaaa agatggtcta aatacgttaa 8641 gttcttttct cataagaagc tcaaaacttc cttctgctcc ttcaaattga tatccaagat 8701 actctaagtc ctttattctt ttaactactg cctttgtttc gggagaatcc ttgtctattt 8761 taggatttat cctttttaaa gctggaagta ttgtactcct tccagatacc tcagatacaa 8821 gtattcttct tgagtttcca accctagatg gatctatgtg ttcaaaggac tttggattct 8881 ttcttacagc atctatatgc ataccacctt tatgagagaa agcacaattt ccaacataag 8941 caaccctctc attaggtgtc atattacagg cttcacatat atatctaaaa gccactgtca 9001 aatattcaag cttatcattt tttatggtat tatagcccat tttaaggctt agatttgcta 9061 ttatgtttga taaattagca tttccacatc tttctcctac acctgtaaag gttccttgaa 9121 catgattaac tccataatgc actgctacaa ctgaattggc tactgccatg ccgctgtcat 9181 catgaaaatg tactcccaaa ttatcaaagt ttaaatccct tactaagtac ttgactatgt 9241 cactcacttc atttggcata gttcctccat tggtgtcaca aagcacaatc cattttgctc 9301 ctgctaatct cgcagtattt aaaacttcta tggcatattc tttattgctt ttaaaaccat 9361 caaagaagtg ttctgcgtca aatacaactt ccttattcaa agaaactaag tattttatgc 9421 tatctctaat catgtttaaa ttttcttcaa tagaggtttt tattatatct gtaacatgaa 9481 agtcccatgc cttaccaaat atagagaata catttactcc actatctacg agttttttta 9541 ttccttcatc ttcctcagcc tttgcacctg ctcttctagt acttccaaat gcacacaact 9601 tagaatgttt aagctttaaa cttcttattt cttcaaagaa ttctctatct tttgggtttg 9661 agctaggatt tccagcttct atatagtcaa ttcccagttc atctaacttt tttactattt 9721 taatcttatc agccacacta aaggaaacac cttgtgcttg agaaccgtct ctaagtatac 9781 tatcaaaaat gtacaccttc ttttccttgc ccatattgta acctcctaac ttgttgaatt 9841 agatttaaaa ttatgactat taagattatt gaaattttta gattattctt taatttcaga 9901 ttatctttta gttcaataat ttttggtata aaaaaacgac ccacattctc tccttggggc 9961 gagaactctg gccgcgcggt accacccaaa cttttaactt aaagcaataa caaggcacta 10021 ctaactttta aatttaaacg tacttcttta aattcacatt taattaaata gtgactaaag 10081 cttttatttg attatttaaa aactcgatat acaaattcaa ctcatcatca attggactat 10141 gaaatgataa taatacctaa ttcaaaaaat gtcaacacta tttttatttt attgttatta 10201 ttttttatat agtaatcttt ttttaataat gtcaatcttg aaaacaatat tatttaacga 10261 tttagtaatt tcatttcttc taaatattat attattaata atataatatt tagataaata 10321 agtttaatac tggaaatttg ttaaacatga aaaaatacaa aaaaggatta ttgacacata 10381 ttttttttta tagtatagta atcataagtt caaaaactat gacggagaaa agtaaacaaa 10441 aatatgcttt cagagagtgg gagttggtgc gaacccataa gctaaagttg ttgaaaatca 10501 ctccagagtt gcaagctgaa atttatatgt aacaatataa agactaggtg acgccggtag 10561 acgccgttat aattataaga gtaataattt gggtggtaca gcgacagata ttcgccccat 10621 ggcggtctgt ggttgttttt ttgtactcat tttgctttta ttattgttta gaaactctca 10681 tcatacatca atcaattaga ctattaaaaa tttgcaattg caaaaatttt tagaaaaata 10741 aaggaaatca tctatatttc tgatttccaa tatattatta acttagtata gaattttggc 10801 ctcgctctat agctatgctt ccgctgctta caacttcaat aattccataa ggttctagca 10861 ttttttgaaa tgcttctatt ttactgctat ttccagttat ctctatagtg aaagttttag 10921 ttgtaacatc aacaactgat gctctaaaaa tggataccgt atttagtatt tcttgtcttt 10981 gcactccctc agcattcact ttaataagca ttatttcacg acatactgaa ttttctctat 11041 ttagaagcac taccttatga accacctcaa tcttttttat ctgctttaca atttggtcta 11101 tttcattttc atctttaaca cttgctatta aagtcaatct tgatatctta tcattctctg 11161 taactcctgc tgttacactt tcaagattat atcctcttct attaaagagc ccacaaaccc 11221 tagtaagtac cccaggaata ttatcaacta gtactgataa aacatataaa cgcaaaataa 11281 cacctctccc ttatctttga attataattt tctttaaaat ttaccacttt gcaaactaaa 11341 agtcaacaaa caagttaaaa aaataataat atgataatta aagctattat acttttaaca 11401 ttttaaaaat gatgcatgta caaaagttta atttaacaaa atagcagatt agaacatttc 11461 ataaaacatt ctaacctgct atttttatta ttcattattt atcaataaac ttccacctta 11521 ttccttcagg tgtatcctct aatactattc ctctttcttt aaggtcatct cttattttat 11581 ccgcaagtgc ccaatcttta tttttccttg cattttgtct ttgctctata agattttgta 11641 tttcatcttc tagattatgt ttttcaacct tttgaagtat tccaagaggt tttccaagtt 11701 ctctcataag acttatagcc ttctcaacag cagccttgct tgattttcca tttatattta 11761 tattaatatc cttagctaaa tcaaatatta cagaaatacc gtctgctgta ttaaaatcat 11821 catccatttt ttctataaac ttttctctat agctatccag tgcttttaaa tattcactat 11881 catcattact ctcagctgta ttatttaaaa ggcttcccaa attgtttatt gtattataaa 11941 gtctttcaag agatgtctta gcagcctcta ttgactcctc agtaaaatta agtggtgttc 12001 tataatgagc tgataatagg aataatctta taacctctgc atcatactcc ttaagaatgt 12061 ctcttgctgt taagaaatta tttaatgact tagacatttt ctcattattt atatttaagt 12121 aagctgcatg catccaatac tttgaaaatg gctttccagt tctagcctca ctttgagcta 12181 tttcattttc atgatgaggg aaaattaaat ctatagctcc tgcgtgaata tctatagtat 12241 cacctagtaa atctcgagcc atgcatgagc attctatatg ccatcctggt cttcctttcc 12301 cccatggact ctcccaagat ggttctccag gtttctcgct cttccataat gcaaaatctg 12361 caggactctt ttttctgtca tcaactgcta tagttgctcc agccattcta tcctctaaat 12421 tctgccctga caactttcca tattccttaa aggcgtttgt attaaaatat acatctccat 12481 caatttcata tgcataacct tcatcttgaa gaccttttac aaaatctatt attttaccta 12541 tatattctgt tgctcttgga ttacaagttg ccctttccaa attaagacca tctgcatcct 12601 catagtattc ctttatatat ctgtctccaa gctcctttac actaactcct tcattattag 12661 cctttgctat cattttatca tctatatcag taaaattttg aataaagtta accttatatc 12721 ccctatactc aaaatatttt cttacagtat caaaaacaat aaaggttcta gcatttccta 12781 tatgaaaaaa attataaact gttggaccac aaacgtacat ttgtacctca ttaggcttta 12841 ccggaacaaa ttcttctttt ttccgagtca tagtattata tattttcatg ttattcctcc 12901 ttgtctacag tatttaactt tcaattctat ttcaacgcta agttattttt ttcaaactct 12961 tcttcaactc tagctataac tttatctaaa tctataactt ctacttcttc actgtttctg 13021 cacttaaatt ctactttgcc ttcagatatt ttctttccaa cggttattct cattggaata 13081 cctattaaat ctgcatcttt aaatttaact ccggctcttt catttctatc atccaaaagg 13141 gcatctaccc ctattttctt aagctcggta tataactttt cagcttcttt catttgctct 13201 tcgcttttaa ataccgctgg aacaactata acctcgtatg gtgctacaga taaaggccaa 13261 actattccgt tatcatcatg gtgttgttca acaactgctg acatagttct attaactcct 13321 ataccatagc agcccattat aagtggctta ctttctccat tttcatctac aaagtatgcc 13381 ttcatagcct ctgaatattt tgttccaagc ttaaatatgt gaccaacctc tattcctctt 13441 gctattgtta atggtttgcc acatttagga cacttttctc cctcaacagc atttctgaaa 13501 tcacccactg tacctttgaa atctctatca taatttgcat ttgcatagtg gtatcctgtc 13561 tcattagctc ctacaataaa attgtacata tatgttactt cattatcaat aagtaaataa 13621 tccacatcta aacctattgg tcctgcaaat ccaacctcag ctcctgttgc ttttttaact 13681 gttttttcat ctgcaagctc aacatctact gaacctactg catttttaac cttagtttca 13741 ttgacttctc tgtctcctct taccattaca gcaacaactt tattctctgc tctatatatt 13801 atagttttaa caaatttttt ggaatccaca ccaaaaaact ccactaactc ttctatggtt 13861 ttcgcatgag gtgtttcaac ttttttaagt tcccctaatt cttctttatc agctttttct 13921 ggaacagctg gtgccttctc tatattagct gcataattac attctgtaca aaaagctatt 13981 tcatcttctc ctatttcgga cttaaccatg aattcagctg aaccagatcc acccatagct 14041 cctgaatctg cggcaactgc actacaactt acattacatc ttttaaatat tttagtatag 14101 gcttcataca tcttattata agatacgtcc aatccttcat tatccttatc aaagctgtaa 14161 gcatccttca taacaaactc tcttgaacgt atcataccaa atcttggtct tctctcatct 14221 ctatactttg tttgaatttg atacaaattt acaggtaatt gcttatatga ctttatttca 14281 cttctagcaa agtccgtaaa gacctcttca tgtgtaggtc caagacaaaa ttctctttca 14341 tttctatcct taagtttgaa catttctggt ccaaatactt cccatctccc cgattccttc 14401 caaagctctg atggtaaaag agctgatgct agaaattctt gagctccagc agcattcatc 14461 tcttctctta ttatattctc aaccttcttt aatgctttta atcctagtgg catataatta 14521 tacactccgg atgccatttt tcttatcatt ccagatctaa gcataagttt atgactttct 14581 atttccgctt ctgctggact ctctcttaaa gttaacatta gcatgtttga cattttcatt 14641 tttaattgtc ctcctataaa ttttatttac aaaaaaaata aaaactcccc cagtattagg 14701 gcgagtatga tcgcggtacc acctaaattt gtactcatta attaaaactc aaaagcaggt 14761 tcaaagctag gttgaaaatc tttcagccat ggattttctc tctgaattta tgaagcttct 14821 actattcttt atcacagttt tactattagt ttttcttaat ttattattat acgtttttaa 14881 atattatgtg tcaatagttt tattacctct tattgtgttt tgtatcaaat taaacatatt 14941 attgacttaa gtgtaatttt ataatataat tgcactaaac atatatgttt actataattc 15001 agttggtata aaataaagaa accagtttaa aagctttact gtatctggtc tcttcaaaat 15061 aaatttaata gttcatctgt ttaccagaca aactggaggc agagtatttt ttataatatg 15121 aaaaatactc tgccttttat tttataaatt ataaggggtg ttaatattga aaagaaaatt 15181 tattactgta gttattccat caataattat agcttcactt ttatcttcct gcacaaatac 15241 ttctaattca actgcagcaa aagctacaaa agtatctagt ctaaaagatc aatatattaa 15301 agctagtttg cctagcaaaa acccggaaaa agcaaaaaat cgcaaagata ccttcattgc 15361 tgcaataagc gaaccaggag gagtttttct tccatacttc tacgataatg gctgggatgg 15421 aaatgccaca gatcctattt ttccttctct agttagcacg gatgaaaaag ggaatccaat 15481 tgcagattta gcagaaaagt gggacatatc ctctgataat ctaacctata cctatcactt 15541 aagaaaaaga ttaaagttca gtgacggctc tcccctaaca tctgatgatg ttgcatttac 15601 cttgacactt ttagatgatc cctcctatag tggcagcttt gacatctcaa cttgctatat 15661 aaaaggaagt accgattata aaaacggtaa agctacttca atatcaggta ttgccgttgt 15721 agacccttta accataaaaa tcacaactga aaagataaat cccttaaacc taactaggct 15781 aggtggtcaa gtactatcaa aagcttatta cggaaaagac tacaaaaaag gaaatcttga 15841 ttacttaaaa tcgctatact caagaccttt aggcgcaggt ccatataaac ttgataaata 15901 cattcccggt caagaaatac gatatactgc aaatgaaaat tattacaaag gaaaacctaa 15961 aatagaaaac tttattttta aggttactag taaggataca aaccttcaat tgtttcagac 16021 aggagaaatt gattctgatt catttagcac agacaaagac accgtagatc agcttgaaaa 16081 cttagggttt gccaatatac gaattagcac tgtaagtgac tatggttttg tatatatgaa 16141 taacaaaaaa ccttacttaa aagataaaaa tgttaggcag gctcttattt atggtcttga 16201 tcgtcaaaaa attgttgatg tagcatacaa aggctatgga gaggtggcta acgtacctac 16261 ttcacctctt gtattgtcct acactacaga tggaattaat tcatataaat tcaatcctga 16321 aaaagcaaaa aaattattag aagatgatgg ttggcggctt aattctaatg gaatacgcga 16381 aaaaaatggt caaaagctta agatatcata cttaacttca aaaaatacgg atcaaacaat 16441 acctatagct aaggaaaact ataaagcact aggtatcgac ttcgagcctg aaatcatgga 16501 tttcaacact ttagttgaga aattaaataa aggtgactac gacctagctg ctgtacgcac 16561 aagcggactt gtagatccaa atgactctgt tgaagaattt tcatctaaaa aaacttctga 16621 aaatgtcagt ggatatttca atccaaaggt tgatgaatta atttcagagg gtgtaaatac 16681 cttaaacgtt aagaaacgta aagcaatata taaaaaactc tataaagaat tatcagacga 16741 cccaccagtt atattaatag attataggaa gggcttaaag gcttggaaca gtagaattaa 16801 gggtatggaa aatgataatt ttgcaggagt ttcatctact aatttatcaa aattaaagat 16861 agaaaattaa ctgtgtacag tttctaatta agcttttagc ctatacatgc ccttattaat 16921 cttttatagc atgtataggt taatatttat aggaggatgc ttatgaaaaa atatatatta 16981 cgcagatttc ttcaaatgat tcctacactt ataggagtct ccattattat tttctattta 17041 ttttctttaa tgcctggaga ttatatagat tcaaaccgaa accttacacc acaaagggca 17101 cacgaactta gagttctaaa tggtttcgat aaaccaatca tagttagata tcttatatgg 17161 ttaagaaata ttttgcacgg agattttgga ttttcattga aatatttaga gccagtaaca 17221 actctaataa atcagtatat atggaactca ttcatcatag ctattgttac cctaattctt 17281 acttggtcca ttgctctagt aatcggaata ttctcagcta caaaacaata ttcctttttt 17341 gacagagtaa taacactgct tgtatttgca tcattgtctt ttccatcatt ttttataggc 17401 cttttaatga ttaaattctt tggagttgat ttaaaaattt tacccatcgg tggtatggtg 17461 gaaaccggaa gcaccaccat aggactttct catattttag aagtaattcg tcatatgatt 17521 cttccagttg gtatacttac attcttaagt attggatcac ttacaagata tttcagaagt 17581 agtatgttag acgtacttaa acaagatttt ataagaactg ctcgtgcaaa tggacttaaa 17641 gaaagaaaaa tcatctttaa acatgctcta aaaaatgcta ttctacctgc aattacactt 17701 ctatctttcg agctccccgg acttttttca ggtgctatta taactgaaca aattttcaat 17761 tggcctggaa taggaagaat acagcttgaa gctcttagtt tcagagatta ccccgtactc 17821 atgactttta caatgctact ttcatttctc actattttcg gtaatttctg tgcggatatt 17881 ttatatgcag cagcagatcc acgaataaga ttagaataga aagggtgaat actacgtgtt 17941 tctttttaag aataagaata tcaaaacttc taataaatcc ttatcaaaac aaacacttaa 18001 aagaatttta aaaaataagt tagctataat gagtatcatt ttccttatat ctatactcat 18061 atttaatttt ttaggcccat ttttctctcc ctattcttac aatgatattg atgtaagttt 18121 aattaaacag cctcctagta tctctcattt attaggaaca gatgactacg gtagagatgt 18181 tcttactaga ttaatgtacg caggtagaat atctcttact gttggccttg cttccatgat 18241 tctttctctt cttttaggaa gtatacttgg ttgtttatca ggatattatg gaggtatatt 18301 agacatcata cttatgagat tatccgatat attgatgtcc attcctggat tacctctttt 18361 aattataatt gctgcacttc tatcggaatt aaaagttcca tctgattata gactttatat 18421 cgttatgcta atgttaagct ttgtaggctg gccaggcctt gctagaatgg ttagaggtca 18481 agttctttct cttcgtgaac aaaattttat gaaagcagct gatatactag gactaagtga 18541 taaaagaaag atttttcatc atttactacc gaataccttt cctttgttaa tagtcgttgc 18601 tactttgagt actgccgacg gtatattaag tgaatcttcc ttaagctttc ttggtcttgg 18661 tgtaattcca ccaacaccat cctggggaaa tatgataaat gcggccaata acttaataga 18721 ttttcaaaaa cgctcctggc tctggatacc acctggtctg gctatatttc tcactgtaat 18781 ttcaataaat ttacttggtg atgcattgag agatgctttg gatcctaaaa tgaaaggtag 18841 ataa //