LOCUS NC_002737:4 18998 bp DNA linear BCT 03-OCT-2011 DEFINITION Streptococcus pyogenes M1 GAS, complete genome. ACCESSION NC_002737 SOURCE Streptococcus pyogenes M1 GAS, complete genome. COMMENT locus start: 1644602; locus end: 1663599 FEATURES Location/Qualifiers source 1..18998 /organism="Streptococcus pyogenes M1 GAS, complete genome." gene complement(0..1133) /gene="msmK" /locus_tag="msmK" /db_xref="1644602..1645735" CDS complement(0..1133) /gene="msmK" /product="multiple sugar-binding ABC transport system (ATP-binding protein)" /translation="MVELNLNHIYKKYPNTTHYAVEDFDLDIKDKEFIVFVGPSGCGK STTLRMIAGLEDISEGELKIGGEVVNDKSPKDRDIAMVFQNYALYPHMTVYDNMAFGL KLRKYKKDDIDRRVKEAAQILGLTEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMD EPLSNLDAKLRVSMRAEIAKIHRRIGSTTIYVTHDQTEAMTLADRIVIMSATKNPQGN GTIGKIEQVGSPQELYNLPANKFVAGFIGSPAMNFFEVEVKDGRIVSEDGLDIAIPEG QAKMLEAAGYKGEKVTFGIRPEDISSRQIVHDTYPSATVTAEVLVSELLGSETMLYVK LGQTEFASRVDARDFHSPGEQVSLTFNVAKGHFFDRDTEQAIR" gene complement(1431..2279) /gene="lrp" /locus_tag="lrp" /db_xref="1646033..1646881" CDS complement(1431..2279) /gene="lrp" /product="leucine-rich protein" /translation="MELKDYFPEMQVGPHPLGDKDWMSIKEGDQYVHFPKSCLSEKER LLLEVGLGQCEVLQPLGSPWQRYLLDHQGNPPQLYETSQFIYLNHQQALPDDLVELLQ QMIAGLEVILPISATQTAFLCRQAISIKVLRWLEDLLPTLESDFGLALTMFVGNAWYQ VAAGTLRECFEEECQLLTAYLRQQSGRKLLTFSGLMLWSLLSHHTFLALTRQFHQFLS PQSDMADVVHALWSEHGNLVQTAQRLYIHRNSLQYKLDKFAQQSGLHLKQLDDLAFAH LFLLKY" gene 2639..3961 /gene="ska" /locus_tag="ska" /db_xref="1647241..1648563" CDS 2639..3961 /gene="ska" /product="streptokinase A precursor" /translation="MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQL VVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEK ADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQE FLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGD TITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQ AYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELL KSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVT VYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK" gene complement(4059..4502) /gene="" /locus_tag="" /db_xref="1648661..1649104" CDS complement(4059..4502) /gene="" /product="D-tyrosyl-tRNA deacylase" /translation="MKLVLQRVKEASVSIDGKIAGAINQGLLLLVGVGPDDNAEDLAY AVRKIVNMRIFSDADGKMNQSIQDIKGSILSVSQFTLYADTKKGNRPAFTGAAKPDLA SQLYDSFNEQLAEFVPVERGVFGADMQVSLINDGPVTIILDTKCH" gene complement(4517..6748) /gene="relA" /locus_tag="relA" /db_xref="1649119..1651350" CDS complement(4517..6748) /gene="relA" /product="(p)ppGpp synthetase" /translation="MRNEMAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHF YQVRKSGEPYIVHPIQVAGILADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGHDA RDIVDGVTKLGEVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLR KDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRRER EALVEAIVSKVKTYTTQQGLFGDVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVM ETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKD MHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKE DIFSERIYVFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKT GDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQFFKNQDKELSVNKGRDLLVSYFQE QGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEERA KAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGY ITKGRGIAIHRSDCHNIKSQDGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLND VLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTTVVEKIKAVPDVYSVKR TNG" gene complement(6988..8034) /gene="scl" /locus_tag="scl" /db_xref="1651590..1652636" CDS complement(6988..8034) /gene="scl" /product="collagen-like surface protei" /translation="MLTSKHHNLNKLVWRYGLTSAAAVLLAFGGGASSVKAEVSSTTM TSSQRESKIKEIEESLKKYPEVSNEKFWERKWYGTYFKEEDFQKELKDFTEKRLKEIL DLIGKSGIKGDRGETGPAGPAGPQGKTGERGAQGPKGDRGEQGIQGKAGEKGERGEKG DKGETGERGEKGEAGIQGPQGEAGKDGAPGKDGAPGEKGEKGDRGETGAQGPVGPQGE KGETGAQGPAGPQGEAGKPGEQGPAGPQGEAGQPGEKAPEKSPEGEAGQPGEKAPEKS KEVTPAAEKPADKEANQTPERRNGNMAKTPVANNHRRLPATGEQANPFFTAAAVAVMT TAGVLAVTKRKENN" gene 8416..8898 /gene="" /locus_tag="" /db_xref="1653018..1653500" CDS 8416..8898 /gene="" /product="hypothetical protein" /translation="MPQITLVFISLSGNTLSFVKRLSLYLADNYDYHVKQINIKDLKH ETFPVKEEFVAILPTYLEGGNGVDSGDVEILTTPLGEFIAAHGNAQRCLGIIGSGNKN FNHQYCLTAKQYAKRFGFPLLGDFELRGTPDDISRLAQVIMEASSRHSSNDTQTLPNS" gene complement(9292..10110) /gene="" /locus_tag="" /db_xref="1653894..1654712" CDS complement(9292..10110) /gene="" /product="hypothetical protein" /translation="MTKVLTLNTHSWMQANTLKKLVALAEHILAEKYDIICLQEINQL IESELATDLPRYQALSGTPSIHKDHFALLLIHYLQKRGQHYYWSWAYNHIGYDIYQEG VAILSKQPIHVSDILVSAMDDETDYHTRRSLIAKTTLDGKEVAVVNVHLSWFDKGFLG EWEKLEKELLTLNCPLLLMGDFNNPTDQDGYQVMMGSPLDLQDSHKGADHVFGDHSIV ADIDGWQGNKEALKVDHVFTSKDFIIRSSKITFEGGDAPVVSDHYGLEVTLGWR" gene complement(10193..12379) /gene="" /locus_tag="" /db_xref="1654795..1656981" CDS complement(10193..12379) /gene="" /product="putative PTS system, enzyme II, A component" /translation="MKTSFKQLFRFEFWQKFGKCLMVVIAVMPAAGLMISIGNSIPMI NHDSAFLASLGNIIAQIGWAVIVNLHLLFALAIGGSWAKERAGGAFASGLAFVLINRI TGAFYGVSSTMLADPEAKITSLLGTQMIVKDYFTSVLESPALNTGVFVGIIAGFVGAT AYNKYYNYRKLPEVLTFFNGKRFVPFVVILRSIFVALILVVVWPVIQSGINSFGMWIA SSQDSAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYEVMTGAAAGTKVFGQ DPLWLAWVTDLVHLKGSDASAYSHLMDSVTPARFKVGQMIGATGTLMGVALAMYRNVD ADKKHTYKMMFISAAAAVFLTGVTEPLEYLFMFAAMPLYIVYALVQGASFAMADLVNL RVHSFGNIELLTRTPMALKAGLGMDVINFVWVSVLFAVIMYFIADMMIKKMHLATAGR LGNYDADILGDRNTQTRPTQVADSNSQVVQIVNLLGGAGNIDDVDACMTRLRVTVKDP AKVGAEDDWKKAGAIGLIQKGNGVQAVYGPKADILKSDIQDLLDSGALIPEVNMSQLT SKPTPAKDFKHVTEDVLSVADGMVLPITGVKDQVFAAKMMGDGFAVEPTHGNIYAPVA GLVTSVFPTKHAFGLLTDNGLEVLVHVGLDTVALNGVPFSVKVSEGQRVHAGDLLVVA DLAAIKSAERETIIVVAFTNTTEIQDVTLTSLGAQPAKTKVATVEL" gene complement(12737..13486) /gene="" /locus_tag="" /db_xref="1657339..1658088" CDS complement(12737..13486) /gene="" /product="hypothetical protein" /translation="MQQYFIKGKAEKKVTITDKDTIKHMFQVMRLADEAEVVLVFDDG VKYLAKVTNSMAHELEIIEALPDQVELPVKVTIASGFPKGDKLDTIAQKVTELGASAL WGYPADWSVVKWDGKKLAKKEDKLAKIVLGAAEQSKRNRVPEVHLFEHKAEFLKSLSS FDHIFIAYEETAKAGQLATLAREVKEVKPGAKILFIFGPEGGISPTEITQFEAASAIK VGLGPRIMRAETAPLYALSALSYALELQASK" gene complement(13486..14439) /gene="" /locus_tag="" /db_xref="1658088..1659041" CDS complement(13486..14439) /gene="" /product="ribosomal protein L11 methyltransferase" /translation="METWQEVTVHVHRDAQEAVSHVLIETGSQGVAIADSADYIGQKD RFGELYPDVEQSDMIAITAYYPSSTNLADIIATINEQLAELASFGLQVGQVTVDSQEL AEEDWADNWKKYYEPARITHDLTIVPSWTDYDASAGEKVIKLDPGMAFGTGTHPTTKM SLFALEQILRGGETVIDVGTGSGVLSIASSLLGAKTIYAYDLDDVAVRVAQDNIDLNQ GTDNIHVAAGDLLKGVSQEADVIVANILADILVLLTDDAYRLVKKEGYLILSGIISEK LDMVLEAAFSAGFFLETHMVQGEWNALVFKKTDDISGVIGG" gene complement(14510..14941) /gene="" /locus_tag="" /db_xref="1659112..1659543" CDS complement(14510..14941) /gene="" /product="hypothetical protein" /translation="MDKHFQYDYAMDWDKKNHAVEVTFVLEAQNKEAIKTIDDSGEVT QDDIVFEDYVLFYNPAKSQFDAADYLVTIPFDAKKGFSREFLAYFAQFLNDVAIEGHS DLMDFLADDSKADFFLEWNAQAFEEGQQGLEEAASYPYPRY" gene 15180..16937 /gene="pabB" /locus_tag="pabB" /db_xref="1659782..1661539" CDS 15180..16937 /gene="pabB" /product="putative para-aminobenzoate synthetase" /translation="MHRKTIIDFKELGQRYLFDEPLVELVAKSLDQVGPVIEKVQHYQ QLGYYVVGYLSYEAAAFFDNALQTHNDRLGNEYLAYFTVHKTCQKKDLPLDYDSITIP NQWVSATQKEAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAADSLAIYNKLVVEQA AGYNAYIAHDEFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQAD GKNRSENMMIVDLLRNDMGKICQTGSVRVDRLCEVERYSTVWQMTSTIVGDLKADCDL IDILKALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTI QLSHNQATYGVGGGITWQSKWEDEYEEVHQKTAFLYRHKQIFDLKTTAKVEHKKIAFL EQHLNRLKEAATYFAYPYNEKALQKQLSTYLENKNNAAYRLMIRLSKDGKISLSDQPL EPLSADFLTAQLSLQKKDVTASPFTYFKTSYRPHIEQKSYEQLFYNQAGQLLETSIGN LFVQLGQTLYTPPVAVGILPGLFRQELLATGQAQEKEVTLADLKEASAIFGGNAVRGL YPLNLELTHLDALLAKSQA" gene 16970..17536 /gene="trpG" /locus_tag="trpG" /db_xref="1661572..1662138" CDS 16970..17536 /gene="trpG" /product="anthranilate synthase component II" /translation="MILLIDNYDSFTYNLAQYLSEFDETIVLYNQDPNLYDMAKKANA LVLSPGPGWPKEANQMPKLIQDFYQTKPILGVCLGHQAIAETLGGTLRLAKRVMHGRQ STIETQGPASLFRSLPQEITVMRYHSIVVDQLPKGFSVTARDCDDQEIMAFEHHTLPL FGLQFHPESIGTPDGMTMIANFIAAIPR" gene 17569..18837 /gene="" /locus_tag="" /db_xref="1662171..1663439" CDS 17569..18837 /gene="" /product="hypothetical protein" /translation="MPDHLALRMRPKTISEVIGQKHLVGEGKIIRRMVEANRLSSMIL YGPPGIGKTSIASAIAGTTRYAFRTFNATIDSKKRLQEIAEEAKFSGGLVLLLDEIHR LDKTKQDFLLPLLENGTIIMIGATTENPFFSVTPAIRSRVQIFELEPLSNEDIKTAIQ LAISDKERGFPFLVTIDDEALDFIVTATNGDLRSAYNSLDLAVMSTSPNEDGSRHISL ETMENSLQRSYITMDKNGDGHYDVLSALQKSIRGSDVNASLHYAARLVEAGDLPSLAR RLTIIAYEDIGLANPDAQVHTVTALDAAQRIGFPEARIPIANVVIDLALSPKSNSAYL AMDAALADLRTSGNLPIPRHLRDGHYAGSKDLGNAKDYLYPHAYPEKWVKQQYLPDKL VGHHYFEANETGKYERALGSNKERIDKLSD" ORIGIN 1 ttaacgaata gcttgttcgg tatctctgtc aaagaaatgc cccttagcca cattaaaggt 61 caagctaact tgctcccctg gactatggaa atcacgcgca tctacacgag aagcaaactc 121 agtttgtcca agcttgacat agagcatcgt ctcagagccc agtaactcag aaaccaaaac 181 ttctgctgtg acagttgcac ttggataagt atcatgcacg atttgtctac tagaaatgtc 241 ttctggacga ataccaaaag tgactttttc ccccttgtaa ccagcagctt caagcatttt 301 tgcttgtcct tctggaatag caatgtcaag accatcttca ctcacaatgc ggccatcttt 361 aacttccact tcaaaaaagt tcatggcagg gcttccgata aaaccggcaa cgaatttatt 421 agctggaagg ttgtacaatt cttgtggcga gccgacttgc tcaattttac caatcgttcc 481 attaccttga gggtttttag tggcactcat gataacgata cggtctgcca aagtcatggc 541 ttcggtttgg tcatgggtaa cgtaaatagt tgttgagccg atacgacggt gaattttagc 601 aatttcagca cgcatagaca cacgaagctt cgcatccaag tttgacaaag gctcatccat 661 caagaatacc ttagcatcac ggacaatagc acgccccatg gcaacacgct gacgttgacc 721 accagacagg tcagccggtt tacgctctaa aaattcggtc aaaccaagaa tctgcgcagc 781 ttccttgaca cgacggtcaa tatcatcttt tttgtactta cgtaatttca aaccaaaggc 841 catgttatca tacacagtca tgtgtgggta aagggcgtag ttttgaaaga ccatggcaat 901 atcacggtct ttaggagact tgtcattcac cacttcgcca ccgattttta actctccttc 961 agaaatgtcc tcaagacctg caatcatacg aagagtagtc gatttaccac atcctgaagg 1021 tccaacaaag acgataaatt ctttgtcttt aatgtctaag tcaaaatctt caacggcata 1081 atgagtagta tttgggtatt ttttatagat gtgatttaga tttaattcaa ccatgtgtaa 1141 ctcctatttg aacagcaaac gttctagctg actgcaaagc tagaaaccac tgatatcttt 1201 tatatgatgc ttttattata acaaaaatag cgctttcaaa acagagacaa agcgaccaaa 1261 cttctttggg caacttgcac aatagcaggg ctagtcaagt cgtaaagacc cataaaacaa 1321 gaaaaccatg taaacacagg ccggtcacag gagccaaaac aagctgaacg atctatcatt 1381 ctccctatca gctacagtcc aggcagcaaa aaagaaagcc ctgtgccttt cctaatattt 1441 caacaaaaag agatgagcaa aggctaaatc atccaattgc ttcaagtgga gtcctgattg 1501 ctgagcaaat ttatcaagtt tgtattgcaa ggagttacgg tgaatataca agcgctgcgc 1561 tgtctgcacc agattgccgt gttctgacca tagcgcgtga accacatcgg ccatatcact 1621 ttgaggactt aggaattggt gaaactgacg cgtcaatgcc aaaaaagtgt ggtgcgacag 1681 caaagaccac agcatcagtc ctgaaaatgt taataatttt ctgcctgatt gttgccttaa 1741 ataggccgtt aacagctgac attcctcctc aaaacactct ctcaatgtac ccgcagctac 1801 ctgataccag gcatttccaa caaacatggt taaggccaaa ccaaaatcac tttctagcgt 1861 tggcaggaga tcttcaagcc agcgcaagac ctttattgag attgcttgtc ggcataaaaa 1921 tgccgtttgg gttgcactga taggcaaaat gacttcaagc cctgcaatca tttgttggag 1981 caactcaact aagtcatctg gtaaagcctg ctgatgatta aggtaaatga actgagaagt 2041 ctcatacagc tgagggggat tgccctgatg atcaagcaaa taccgctgcc aaggtgaccc 2101 tagcggctgc aagacctcac actgacccag ccccacctca agtaataagc gctctttttc 2161 ggataaacat gatttgggaa aatgcacata ttggtcccct tctttgatac tcatccaatc 2221 tttatctcct aacggatgag ggcctacttg catctctgga aaatagtctt ttagctccat 2281 agccattcct ttcatgacgg tctttaaacc attataacac atgactcttt atcacacagt 2341 tcggtttgtt gtcagcacga ttttgtattt tctgcctttt taatcattaa agctaaataa 2401 tggttattca tttttagcaa gaacattcaa tcaaatggct atttatcgga agattaattt 2461 aatttattgg aagattaatt tatgtttata ctaaaaaagt attgttgccc ttttttcatt 2521 atcatgacat tatcattaag atatcattta aaaacaatca ttagattttt gtttgtatct 2581 ataaaattat tatgttattc taataatggg gattgaaact taacttttag gaggtttcta 2641 tgaaaaatta cttatctatt ggagtgattg cactgctgtt tgcattaaca tttggaacag 2701 tcaagtcggt ccaagctatt gctgggtatg gatggctacc agaccgtcca cctatcaata 2761 acagccagtt agttgttagt atggccggta tcgttgaagg taccgataaa aaagttttta 2821 taaatttttt tgaaatcgat ctaacatcac aacctgctca cggaggaaag acagagcagg 2881 gcttaagtcc aaaatcaaaa ccatttgcta cagataatgg cgcaatgcca cataaacttg 2941 aaaaagctga cttattaaaa gctattcaaa aacagctgat cgctaacgtt cacagtaacg 3001 acggctactt tgaggtcatt gattttgcaa gcgatgcaac cattactgat cgaaacggca 3061 aggtctactt tgctgacaaa gatggttcgg taaccttgcc gacccaacct gtccaagaat 3121 ttttgttaaa gggacatgtg cgcgttagac catataaaga aaaaccagta caaaatcaag 3181 caaaatctgt tgatgtagaa tatactgtac agtttactcc tttaaaccct gatgacgatt 3241 tcagaccagg gctcaaagat actaagctat tgaaaacact agctatcggt gacaccatca 3301 catctcaaga attactagct caagcacaaa gcattttaaa caaaacccac ccaggctata 3361 cgatttatga acgtgactcc tcaatcgtca ctcatgacaa tgacattttc cgtacgattt 3421 taccaatgga tcaagagttt acttaccatg tcaaaaatcg ggaacaagct tatgagatca 3481 atcctaaaac aggtattaaa gaaaaaacga acaacactga tctggtctct gagaaatatt 3541 acgtccttaa acaaggggaa aagccgtatg atccctttga tcgcagtcac ttgaaactgt 3601 tcaccatcaa atacgttgat gtcaacacca acgaattgct aaaaagcgag cagctcttaa 3661 cagctagcga acgtaactta gacttcagag atttatacga tcctcgtgat aaggctaaac 3721 tactctacaa caatctcgat gcttttgata tcatggacta taccttaact ggaaaagtag 3781 aggataatca cgataagaat aatcgtgtcg ttacagttta tatgggcaag cgccctaaag 3841 gggcaaaggg tagctatcat ttagcttatg ataaagatct ctataccgaa gaagaacgaa 3901 aagcttacag ctacctgcgt gatacaggga cacctatacc tgataaccct aaagacaaat 3961 aaccacgatc ttctaaaatg atgagattaa ctgacaaaaa aagcaagcaa cacgctatca 4021 acagttgctt gcttttttct aacctcttag ttgtagagac tagtgacatt tcgtgtctaa 4081 aataatcgta actggtccat cattgatgag actaacctgc atatctgccc caaaaacgcc 4141 acgctcaact ggcacaaact ctgccaattg ttcattaaag ctatcataca actgactagc 4201 caaatctggc ttagcagcac cagtaaaggc aggacggttt ccctttttgg tgtcagcata 4261 aagggtaaat tgcgacacag ataagatact gcccttgatg tcttggatag actggttcat 4321 cttgccatca gcatctgaaa aaatgcgcat gttgactatt tttcgcacag cgtaagccaa 4381 atcttctgca ttatcatctg gtcccacacc tactaacaac aacaaccctt gattaatagc 4441 gccagcaatt ttcccatcaa tagaaacaga ggcctctttg acccgttgca agacaagttt 4501 catgttttta tcctttctta gccattggtc cgcttcacgc tataaacatc tggaactgcc 4561 ttgatttttt cgacaacagt ggtcagatgc gtcagatttg gaatgccaaa gctcacgtga 4621 atattagcaa acttcatgtc cttggtcggc tgagcattga ctgtcgatat gctcttggtt 4681 gagtttgata aaatttggag cacatcatta agcagaccac tacgattgag cccatagata 4741 tcaatttcag cctgataatc tttactcgaa ttgtccaaat cccactcgac ctcaatcaag 4801 cgttcttggt agccatcttg actcttaatg ttatgacagt ccgatctgtg aatcgcaatg 4861 ccacgccctt tggtaatgta gccgtcaata ggatcaccag gtacaggatt acaacacttg 4921 gcaatccgca tcaagaggcc tgatgctcct tggataatga ctccattttc actgcgaacc 4981 ttgagcacat ctttgttttc gtgtttgacc tcaccgccct taaccaattc ttcagcttct 5041 gctttagcct tggccctttc ttcttcacgg cgctcttttt cggttaactt gttaaagaca 5101 ctgataggac taatgtcacc aaacccaacg gctgcataga gtgattcttc gctcttcaca 5161 ctgacttttg gaaggatggc ttcaatgcgt tttttgtcaa ggtatttatt ggcaacgtag 5221 ccctgctctt gaaaataaga caccaacaaa tcacggcctt tattcactga caattccttg 5281 tcttgatttt taaagaactg acgaattttg ttgcgagcct tattggtttt gaccagtttt 5341 acccagtctc gactagggcc aaaggaattg gcattggtga tgatttcaac cacatctcct 5401 gtttttaact tggcagtgag aggaaccata cgtccattga ctttggcacc tgttgctttt 5461 tcaccgattt gcgtatggat cgcataagca aaatcaatag gacctgattc ttttggtaac 5521 tcctgaacgg cccctgtcgg tgtaaagaca taaatccgtt cagaaaaaat gtcttctttg 5581 accgaatcca caaagtccac tgcatcgcca tttgaggcat cttgcaattc taccagctct 5641 ttgatccagt tcatgccaac ggcttgctca gcttgattga ccttaccacg cacgcctttt 5701 ttataagccc agtgagcagc aaccccgtac tcagccactt gatgcatgtc cttagttctg 5761 atttgaatct caataggtcc ttttggccca tacacggtgg tatgaataga ctggtagcca 5821 ttagctttag gagctgcaat ataatccttg aagcggcctg gcatgggacg ccaaagctca 5881 tgaatatagc caaccatagc atagacatcg ctttgcgttt ccatgacaca acgaatggca 5941 atcagatcaa aaatctgatc gaatcgtttc tttttgtccc gcattttccg ataaatcgaa 6001 taaatgtgtt ttggtcggcc atacacatct ccaaacaacc cttgttgtgt cgtataggtt 6061 ttgaccttac tgacaatagc ctctaccaaa gcttcacgct cgcgacgttt ttctttcatc 6121 atatgggaaa ttttgtaaaa ttcggtttca ttgaggtaac gaaaagccaa atcttctagt 6181 tcccatttga tgcgactaat ccccaaacga tgcgccaagg gggcatagat ttccatggtt 6241 tcgcgcgaaa tgcgctcttg tttgtccttg cgcaaatgtt tgagggtgcg catattatgc 6301 aggcggtcag ccaatttcac caaaatcacg cgaatatctt tggacatagc catcagcatt 6361 ttgcgatggt tttcggcgag ttgctcctca tgagatttgt actcaacttc acctaacttg 6421 gtgacaccat caacgatatc acgagcatca tggccaaagt ctgcttcgat ctcatctaag 6481 gtaatatccg tatcttctac gacatcatgt aaaaagccac aagcaactgt cacagcatcc 6541 agatgcaaat cagccagaat ccccgccacc tgaatcggat ggacgatata gggttcgcct 6601 gactttctca cttggtagaa atgggccgct gttgcatatg ctaaagcctt tgccacaaaa 6661 gccacatcag ccttggtcat ataggtggcc gctaaggcaa tgacttcttc tcctgttacg 6721 ttcattattt ttgccatttc gttcctcatc tagcatttct tttccctatt ttaacacttt 6781 acacacaaaa gcaaaaggca gaatctgcta agaaagcgct tagtgtgacc ttttcttaga 6841 aaacggttag tgagctgctt ttgatatctt ttgggatctc tcaggcgtga gcatgatacc 6901 aaaggcctgc tcccgaccaa aaatagagag aaccaagggg ctctctctat tatgtttgct 6961 tatcagtaag gtctctcaat tcagagaatt agttgttttc tttgcgtttt gtaacggcta 7021 ggacaccagc tgttgtcatc actgctactg ctgctgctgt aaagaatggg ttggcttgct 7081 caccagttgc tggtagacgt ctgtggttgt tggctacagg tgtcttagcc atattgccat 7141 tgcggcgttc tggcgtttgg ttagcttctt tgtcagcagg tttttctgca gctggagtta 7201 cctctttgct cttttctgga gctttttcgc ctggttggcc tgcttcgcct tctgggctct 7261 tttctggagc tttttcgcct ggttggcctg cttcaccttg tgggcctgct gggccttgct 7321 cacctggttt gcctgcctca ccttgtgggc ctgctgggcc ttgggcgccc gtttcacctt 7381 tttcaccttg tgggcctact ggaccctgag ctccggtttc accgcggtca cctttttcac 7441 ccttttcgcc tggagctcca tctttacctg gagcgccatc tttaccagct tcaccttgtg 7501 ggccttggat tccagcttcg cctttttcac cgcgttcacc ggtttcacct ttgtcgcctt 7561 tttcaccgcg ctcacctttt tcaccagctt taccttggat tccttgctca ccgcggtcac 7621 ctttaggacc ttgggcgccc ctctcaccag ttttaccttg tggtccggct gggccagcag 7681 gaccagtctc accacggtct cccttgattc cagatttacc aattaaatct agaatctcct 7741 taagcctctt ctcagtaaaa tcttttagct ccttttgaaa atcttcttct ttaaaatagg 7801 ttccatacca ctttctttcc caaaatttct cattggacac ttctggatat tttttaagac 7861 tttcttcgat ctcttttatt tttgactctc tttgactcga cgtcatagtc gtagaagaaa 7921 cctcagcctt aacgctgctt gccccgcctc caaaggctag aaggacggca gcggctgagg 7981 ttagcccgta gcgccagact agtttgttga gattatggtg ctttgatgtc aacatatgtt 8041 gttctctctt tctttattag atggtgtgtt ttagataaaa ataacatggt agctagacct 8101 gattatttat aatagtatta taatagagtg tgaaaacgat tgtaaagttc tcttttgttg 8161 ttcatctttt agattttgac tgatcactct tttgtggaga tcagagggct actttggcac 8221 ttgcctgcct cgtttttaag tcgagggcat ccggatcctt tctttaaggt cactcttttt 8281 tgaaatgtta ctttttttga ctgcttgtac cttcttgtct ggttggatac cgctaggttt 8341 cttctttact tgtttgttgg tcttgattgt ggtaagctta tgaagaaacc ttgtaggata 8401 aaaaaaggag acacttatgc ctcagattac ccttgttttt attagcctca gtggcaacac 8461 ccttagcttt gtcaagcggc tatcccttta tctagcagac aattacgatt accatgtcaa 8521 acagattaac attaaagatt tgaagcacga gacttttccc gtcaaggaag agtttgtggc 8581 gattttaccc acttatctag aaggcggaaa tggcgttgac tctggtgatg tggagatcct 8641 caccactcct ttgggagagt ttattgctgc ccatggcaac gcccagcgtt gtcttgggat 8701 tattggctca ggcaacaaaa actttaacca tcagtattgc ctgacagcca aacagtatgc 8761 caaacgcttt ggctttccac tgctaggtga ttttgagctg cgagggactc ctgatgacat 8821 ttcgcggtta gcccaggtca tcatggaggc cagctccaga cactcgtcta acgacacaca 8881 gacactgcct aacagctaga cagtccatag atgatcatag ctgttttaaa aaagagcgct 8941 tttaggacaa taactacaga gggccctacc ccacgccttg tgatttctca gcctttgaaa 9001 agagcgatca cagtgcttct tggggcttgg gatcacacca agcactccta gaaatacccc 9061 catgcagact ttagcaaggc aactgaacgc ttggtggtac tttctgtgaa gctcagatgg 9121 ttggtgacaa aaaagccctg gttttctggg gttactgaca tgactaaaga ggtctaacca 9181 gctctacctt gagctggtta gacctctttg tgttctccta atccccccta gatgatcgca 9241 gtttcttatg tgtcttggct tctcttatgt ggtgtgcctg ttagcacatg ctctaacgcc 9301 agcctaatgt cacttctaga ccatagtggt cactgacgac tggcgcatct ccgccttcaa 9361 aggtaatctt agaagatcgg atgatgaagt ccttactggt aaagacatgg tccaccttga 9421 gggcttcttt gttaccttgc cagccatcaa tatcagccac gatgctatga tcaccaaaca 9481 cgtggtcagc acccttatgg ctatcttgta ggtctagggg gctacccatc atcacttgat 9541 aaccgtcttg atccgttgga ttgttaaaat ctcccataag tagcaaggga cagtttagtg 9601 tgagcagttc tttttctaat ttctcccact cccctaaaaa ccccttgtca aaccaagata 9661 ggtgcacatt gacaacagcg acttctttgc catctaacgt ggttttggct atgagtgagc 9721 gtctggtgtg gtagtctgtt tcatcatcca tcgctgacac gagaatatct gaaacatgaa 9781 taggttgttt tgataagatt gccacgcctt cctggtaaat gtcatagcca atatggttat 9841 aagcccaaga ccaataatag tgctgccctc gtttttgtaa ataatggatc aagagaaggg 9901 caaaatggtc tttatgaatg cttggtgtcc ctgaaagagc ttgatatctt ggtaaatctg 9961 tggccagctc gctctcgatt aactgattga tttcttgcaa gcaaatgata tcgtattttt 10021 cagctaaaat atgctcagcc aaagcaacta attttttaag agtgttggct tgcatccacg 10081 aatgggtatt cagtgttaat accttggtca ttaatcctcc tttataagac aagaagagcc 10141 atagggccta aaccagctat ggctattacc tatcactatc tcgtgatgtt ttgttaaagt 10201 tctacggtag ctactttagt cttagcaggc tgagctccta aagatgtcaa ggtcacatct 10261 tggatctctg ttgtgttggt aaaagcaaca acaatgattg tttcacgctc tgctgattta 10321 atagcagcaa gatctgctac gactaatagg tcacctgcat gaacccgttg cccttctgag 10381 actttgactg aaaaaggcac accatttaag gcgacggtat caagtcccac gtgcaccagc 10441 acttcaagac cattatctgt cagtaaacca aaggcatgct tggtcggaaa gacactggtc 10501 acaaggccag ctacgggtgc atagatatta ccatgggttg gttcaaccgc aaacccatct 10561 cccatcatct tagccgcaaa cacctggtct tttacacctg tgattgggag aaccatcccg 10621 tctgccactg atagcacatc ttctgtcacg tgtttaaaat cttttgcggg agtcggtttg 10681 ctagtgagct gtgacatatt gacttctgga ataagagcac ctgagtccag caaatcttga 10741 atatctgatt tcaaaatatc tgctttaggg ccatagaccg cttgaacgcc gttgcctttt 10801 tggatcaagc ctatagcgcc agcttttttc caatcgtcct cagcaccaac cttagcgggg 10861 tctttgaccg tcactcgtaa gcgcgtcata caagcatcaa catcatcaat attgcctgcc 10921 ccaccaagga gattaacgat ttgcacgact tgagagttgc tatctgctac ttgggtaggt 10981 cttgtttgag tgttacggtc acccagtata tcggcatcgt agttgcctaa acggccagct 11041 gttgcgagat gcattttctt gatcatcata tctgcaataa agtacatgat aactgcaaag 11101 aggacagaaa cccaaacaaa gttaatcaca tccatgccta ggcctgcttt aagagccata 11161 ggggtgcggg ttagtagctc tatatttcca aatgagtgaa cacggagatt cacaaggtct 11221 gccatggcaa atgaagctcc ttgaacaagg gcatagacga tgtaaagtgg cattgctgca 11281 aacataaata ggtactcaag tggctcagtt acccctgtca aaaagaccgc tgccgctgct 11341 gagatgaaca tcattttgta tgtgtgtttt ttatcggcat ccacattacg gtacatggct 11401 aaggcaaccc ccatcaatgt tccggtagct ccaatcattt gtcctacttt gaaacgagct 11461 ggagtcacac tatccattaa gtgactatag gctgaagcgt ctgatccttt aaggtgaaca 11521 aggtcagtta cccaagcaag ccacaaaggg tcttgaccaa atacttttgt ccccgctgct 11581 gcacctgtca tgacctcata agttccacca agagctgtat agttcattgg gatcgtcaac 11641 atgtggtgaa gaccaaatgg caacaagaga cgttccaagg taccatatag gaatggggct 11701 aggattggag ctgaatcttg tgaagaggca atccacatcc caaaactgtt aatcccagac 11761 tggatcaccg gccaaacaac aaccaaaata agggctacaa aaatagaacg taaaataacg 11821 acaaatggta caaaacgctt cccattaaag aaggtcaaaa cttcaggaag tttacggtaa 11881 ttatagtatt tgttataggc cgttgctcct acgaaccctg caataatccc aacaaaaacc 11941 cctgtgttta aagctggaga ttccaagaca ctggtgaaat aatctttaac gatcatttga 12001 gtgccaagga ggcttgtgat ttttgcttct ggatcagcta gcatagtact agacacgcca 12061 taaaaagcac ctgttatccg attgatcaag acaaaagcaa gccctgaggc aaaggcccct 12121 ccagctcttt ctttagccca actaccacca atggccaagg caaatagcaa gtgaaggtta 12181 acaataacag cccaaccaat ttgagcgata atgttgccta gagatgccaa aaatgctgag 12241 tcgtggttaa tcattggaat agagtttccg atactgatca ttaaaccagc cgctggcatg 12301 acagcaataa cgaccataag acatttccca aatttttgcc aaaattcgaa acgaaacagt 12361 tgcttgaatg atgttttcat tctatctctc ctttattatc cccttttagc catagctgcc 12421 cttaaggcgc ttttgtgaca caatgatata gacagcaact cagtgatgca atcgcttgca 12481 ttgatctgat acctttatta tactagcctc gcaacaattt gtaaagcgtt ttcttagaca 12541 gatgttagtc gttttttttc attaatatag tagtataact caccaaaaag aggacaagag 12601 cccatttcct tttttggtga tgagcccatc aacgctcttc gaaaaaacaa gaagcaataa 12661 aaaaaggccg ttgacacaat cgtgaactgc ctgtccgttt ctttagcctc ttctttctaa 12721 agtaagcaac agcttactta ttttgatgcc tgcaattcca aagcataact aagagcactt 12781 aaggcatata gcggcgctgt ctctgctcgc ataatgcgag ggcctaagcc caccttaatg 12841 gcacttgctg cctcaaactg agtgatttca gttggggaaa ttcccccttc tggtccaaag 12901 ataaagagga tttttgcccc tggcttaact tcttttactt cacgcgccaa ggtcgctagc 12961 tgacctgcct tagctgtttc ctcataagca atgaagatat gatcaaagct agaaaggctt 13021 tttagaaact ctgctttatg ttcaaaaagg tgaacttcag gcaccctatt tcgtttgctc 13081 tgctcagccg ctcctaatac aatcttagcc aatttgtctt cttttttagc taattttttg 13141 ccatcccatt tgaccactga ccagtctgct gggtagcccc atagcgcact ggctcccaat 13201 tcagtcactt tctgggcaat cgtgtctaac ttatcgcctt taggaaatcc agaagcaata 13261 gtcactttaa caggcaattc cacctgatct ggcaaagcct ctataatctc taactcatga 13321 gccatactat tggtcacctt agctaaatac ttcaccccat catcaaagac caagacaact 13381 tcagcctcgt cagccaagcg catcacttga aacatgtgct tgatggtatc tttatcggta 13441 atcgttacct ttttttctgc tttgccttta ataaaatact gttgcattag ccgccaatca 13501 ctcctgagat atcatctgtt tttttaaaga caagggcatt ccactcacct tgaaccatgt 13561 gagtttctaa gaaaaagcct gcgctaaagg cagcttccag aaccatatcc aatttctcag 13621 aaatgatgcc agataagata aggtaacctt cctttttgac caaacggtaa gcatcatcag 13681 tcaataagac taagatatcc gccaagatat tggctacaat cacatccgct tcttggctaa 13741 ccccttttaa aaggtcacca gcagccacat gaatgttgtc tgttccttgg tttaaatcaa 13801 tgttgtcttg agccactcga acagccacgt catctaagtc ataagcgtag atggttttag 13861 cacctagtaa ggaactggca atcgagagga cacctgaacc ggtccctaca tcgataactg 13921 tctcaccacc acgaaggatt tgttccaagg caaaaaggct catcttagtt gtgggatgtg 13981 tccctgtccc aaatgccatt ccaggatcta gtttaatcac tttttcccca gcagaagcgt 14041 cataatccgt ccaactaggg acaatggtta aatcatgcgt gatgcgagct ggttcatagt 14101 attttttcca attgtctgcc cagtcttcct cagccaattc ttgactgtcc acagtaacct 14161 gaccaacctg taacccaaaa ctagctaact ccgctaactg ttcattaatg gtcgcaataa 14221 tatccgccaa attagtacta cttgggtaat aggctgtgat agctatcatg tcagactgct 14281 ccacatctgg gtataactcc ccaaagcggt ccttttgccc aatatagtct gcgctatctg 14341 cgatagcaac cccttgactg cctgtctcaa tcaacacatg tgaaacagcc tcttgcgcat 14401 cacgatgcac atgaaccgtc acttcttgcc acgtttccat agttatgtcc tttctatttt 14461 gaccttttgg ttattgtcct aatagtgtta gcaccatctc atgtgtcacc ttagtacctt 14521 gggtaagggt aacttgctgc ttcttctagt ccttgttgac cttcttcaaa agcttgcgcg 14581 ttccactcca agaagaaatc agccttgctg tcatctgcta agaaatccat caaatcgctg 14641 tgcccttcaa tagcaacatc gttgagaaat tgcgcaaagt aagctaagaa ttcacgagaa 14701 aagccctttt tagcgtcaaa aggaatagta accaaataat ctgctgcatc aaattgagac 14761 ttggcagggt tataaaagag cacatagtcc tcaaagacaa tatcatcttg ggtcacttcg 14821 ccactatcgt caatggtttt tatagcctct ttattttgag cttctaacac aaaagtcact 14881 tcaaccgcat gatttttctt gtcccaatcc atagcatagt catactgaaa atgcttatcc 14941 atttcttctt ctaatactga taaaaagccg tatgttgcca tcttttttat acctaatctt 15001 tctaactgtt gctgtataag gctttgtaag acctcattag tttacttact ttgacatgct 15061 gagcgtactg ttataacttt tattaactga attataacat atttgactaa tattgaccat 15121 aagagaaggt cttaatggca ggatcacctc tagcaaccgc ttttatgata taatttgggt 15181 atgcatagaa aaactattat tgatttcaaa gagctcgggc aacgctatct ttttgatgag 15241 ccattagtag aattggtagc caagtcctta gatcaggtcg gtccagtcat tgaaaaagta 15301 caacactacc aacagctggg ctattacgtg gtgggctatc tcagttatga agcagctgct 15361 ttttttgaca atgccctaca aacccataat gacagactag gcaacgagta ccttgcctat 15421 tttacagtgc acaaaacctg tcaaaaaaaa gacctacctc ttgattatga cagcattact 15481 atccctaacc aatgggtcag cgcaactcaa aaagaagcct atcaaaaagc cattgaaacc 15541 attcaccgtg agatgcaaca gggcaatact tatcaggtta actacaccct tcaattaact 15601 caggaactca atgcagctga tagtttagcc atttacaata aactcgtcgt tgaacaggct 15661 gctggctaca atgcctacat cgcccatgat gagtttgccg ttatttcagc tagtcctgaa 15721 ttgttcttta aacaagaggg caacaggtta actactaggc ctatgaaagg caccaccaaa 15781 cgaggggtta atagctggct ggatcaacaa gaacatgact ggctccaagc tgacgggaaa 15841 aaccgttctg aaaacatgat gattgtggat ttgctccgca atgacatggg gaaaatttgc 15901 caaacaggca gtgttcgtgt tgataggctc tgtgaggtcg agcgatactc taccgtctgg 15961 caaatgacct caactattgt tggtgacctc aaagcggact gtgacctgat agacattctc 16021 aaagctctct ttccttgtgg ctctatcaca ggggcaccaa aagtctccac catggcaatt 16081 atcacatctc tggagccaaa accaaggggg atttattgtg gaagtattgg catttgccta 16141 cctgatggtc gccgtttctt caatgttccc attagaacca tccagctcag tcataatcaa 16201 gctacttatg gtgtcggagg cggcatcact tggcaaagca agtgggaaga cgaatacgag 16261 gaagtccatc aaaaaacagc ttttctctat cggcacaaac aaatctttga cctcaaaaca 16321 accgccaagg tggaacacaa aaaaatagcc ttccttgagc aacacctcaa tcgccttaaa 16381 gaagcagcca cttattttgc ttacccttat aatgaaaaag ctttgcagaa acaactgtca 16441 acctatttgg aaaataagaa taatgctgcc taccgtttga tgattcgttt atccaaagat 16501 ggaaagatta gcctctctga tcaacccttg gaacctttgt cagccgattt tctgacagct 16561 caactctctt tacagaaaaa ggacgtgaca gcttcgcctt ttacctactt taagaccagc 16621 taccggcctc atattgagca aaaatcttat gaacagctat tctataacca agcggggcaa 16681 ttattggaaa cgtccattgg caatctcttt gttcagctgg gtcagaccct ctacacacca 16741 ccagtggctg tggggatttt accaggactt tttcgccaag aactgctagc tactggtcaa 16801 gctcaggaaa aagaggtgac actagctgat ttaaaagagg ctagcgctat ttttggagga 16861 aatgctgtcc gtggccttta tcctctcaac cttgagctta ctcaccttga tgccctctta 16921 gctaagagtc aagcctaaac tgccactcat cttttgttat taaggaacct atgatactct 16981 taattgataa ttacgattca tttacctaca acctcgccca atatttaagt gaatttgacg 17041 agacgattgt cttgtataac caagacccaa acttatatga catggccaaa aaagctaacg 17101 ctctagtcct ctcacctggt cctggttggc ccaaggaagc caaccaaatg ccaaaactca 17161 ttcaagactt ttaccaaaca aaacctatct taggagtgtg tctgggacac caagctatcg 17221 ctgaaacttt agggggaacc ttacgcttgg ccaaacgcgt catgcatggg agacaaagca 17281 ccattgaaac gcaaggccct gctagtcttt ttcgctccct gccacaagag atcaccgtca 17341 tgcgctacca ttccatcgtt gtggatcagt taccaaaagg ttttagcgta accgctagag 17401 actgtgacga tcaagaaatc atggcatttg aacaccacac cctgccactt tttgggctac 17461 aatttcaccc agaaagcatc ggaactcctg atggcatgac catgattgcc aacttcatcg 17521 cagccattcc ccgttaatct catcccccaa aagaaaggag gacagttaca tgcctgatca 17581 tttagcgctc agaatgcgcc ccaaaaccat ttcagaggtc atcggacaaa aacaccttgt 17641 tggcgaaggc aaaatcatcc gtcgcatggt ggaagcaaat agactatcgt ccatgatcct 17701 ctatggccct ccaggaatcg gtaaaacttc cattgcttct gctattgctg gtactactag 17761 atatgccttt cggaccttta atgccaccat tgacagcaaa aaacgtctcc aagaaattgc 17821 ggaagaagct aaattttctg gtggcttggt attattacta gacgagattc atcgccttga 17881 caagacaaaa caagattttc ttttaccttt acttgagaat ggcaccatta tcatgattgg 17941 cgcaaccact gagaacccct tcttttcagt gacacccgct atcagaagca gggtccaaat 18001 ttttgaattg gaaccacttt ctaacgagga tattaaaaca gccattcagc tagcaatttc 18061 cgacaaagaa cggggatttc cttttttagt gacaattgat gatgaggcgc tagatttcat 18121 tgttaccgcc acaaatggag acctacgatc tgcttataat tccttggatc tagcagtcat 18181 gtctacttct cctaatgaag atggtagtcg tcatattagt ctagagacaa tggaaaatag 18241 tctgcagcgt agttatatta ccatggataa aaacggggac gggcattatg atgttttatc 18301 tgccttacaa aaatccatta gaggttctga tgtcaatgct agcctgcact atgccgctcg 18361 tttagtagaa gctggagact tgcctagttt agcaagacga ttgaccatta ttgcttacga 18421 agatattggc ttagccaacc ctgacgccca agttcatacc gtcaccgcac tagatgccgc 18481 ccaacgcatt ggttttccag aagctcgtat tcctatcgct aacgtggtca ttgatttggc 18541 tctatcacct aaatccaatt cagcttattt agctatggat gcagctttag ctgatttgag 18601 aacatcaggc aacctcccca ttccaagaca tcttagagac gggcattatg ctggcagcaa 18661 ggacctaggc aatgccaaag attacctcta cccacacgcc taccctgaaa aatgggtcaa 18721 acaacaatac ctaccagata aattagtagg acatcattat tttgaagcca atgaaaccgg 18781 taaatacgaa cgcgcacttg gttcaaataa agagcgtatt gataagctct cagactgact 18841 gctagtttta aaaatcgcaa ccgatttcaa aaatcgataa ttttgcttga aaaaatttta 18901 aaaagtggta ttataaaagt acagaaacat tgctgtggca tacgaatcca catctaagtg 18961 ttgaccgact atttctttgt attttcggga aacaaaga //