LOCUS NC_017276:2 18810 bp DNA linear BCT 09-SEP-2013 DEFINITION Sulfolobus islandicus REY15A chromosome, complete genome. ACCESSION NC_017276 SOURCE Sulfolobus islandicus REY15A chromosome, complete genome. COMMENT locus start: 320000; locus end: 338809 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.016141; n0_4mer:D = 18.512889; n0_4mer:PS = 34.279449 FEATURES Location/Qualifiers source 1..18810 /organism="Sulfolobus islandicus REY15A chromosome, complete genome." gene 691..1980 /gene="" /locus_tag="" /db_xref="320690..321979" CDS 691..1980 /gene="" /product="FAD dependent oxidoreductase" /translation="MKYDVIIIGAGHNGLVSSIYLAQKGLKVLVIEARNRPGGMSDTE EYKGVKYSRASYVLGLFPKRIQEELGVVFPTVDSDVADVFVTEDGKVVNIWRNKEKRL EEFKRLGQTKYPKMEELLFKIKEKIEKEMQYVTKPPSFEDFVKAVEGTELEIFTQPSR KFLNEYLDKEFQPYFSYGFMYDLPAYVLAYYFSLDWKIVRGGMGKIGEILMNRAKQLG VDFIFNTKVNEIIIKDNVATGVRTNADKIVESKIVINAVSPVLLNKLTNGLLKVYHPE FRPGWKRDTLILRELPNLPDYVRNHPDTLFTLPIGEVTIPSTVDNSLGGHVMTIMGSY EEAKEFFPDLEKKVVHVDRLDAYKLEREYNAPFGDMNHMPMYTEYLFDGRPVKGWGYT TPVKNLYVTGSGTYPGGQVTGVPGRNAAMKIITDLGI" gene 1983..2498 /gene="" /locus_tag="" /db_xref="321982..322497" CDS 1983..2498 /gene="" /product="hypothetical protein" /translation="MLFTIGHSNRSLEDFMEILRKYNVEILIDVRRWPKSSRYPHFNK ENLKKALEQSGIEYLWKEQLGGYRKIGKDVEDIDIGKCFKSEGFRAYAIYILTNERVM EALEDIRRINKIKVIMCSEKFPWNCHRKIISDWFLARGDEVVHLIEKESTIKHKLTTC AEIVKNNLNYK" gene complement(2510..3319) /gene="" /locus_tag="" /db_xref="322509..323318" CDS complement(2510..3319) /gene="" /product="amidohydrolase 2" /translation="MIKVIDAHVHYHIYARKIPEHCKEFLENVEETSITLKNEFVEIE KILLVPSHPCHSDDCYDGFYIDYEERKRNPDLYLQWGEVNPWRCDVRRELDKQYSLGI IGIKLHPVHHAFKPNAYREEEGGLKQLLYVYEFAEDHDLPILIHTGTSIGVESRNKYA DPIYADDVAKDFPKLRIILAHAGRPLWYNTAFHMARFTRNVFLEISSIPPKNILKVLP RLHEISDKIIYGSDFPAFKGQDLAEYAYQVYNVLKDEKIMRDNAKRILKIS" gene complement(3347..3982) /gene="" /locus_tag="" /db_xref="323346..323981" CDS complement(3347..3982) /gene="" /product="hypothetical protein" /translation="LSVSRVENYLNLQLKKALQINGIGVEEIHDIRVAVRKYFDVLYA LYPVYENVECLFLAKELISKLGKVRDMDICEIINEERNRLAIRAVKEVRGLKICFVNN NIYGARLVIYNRILTSLHQIQDVTDFHELRKSVRVTRNLVEALGYDTTEIKAFAKKMG DIRDEILKMRCRGVTPPDINVNQFKEEAKRVILKIIASQDEFHHFKLKDRY" gene complement(3963..4580) /gene="" /locus_tag="" /db_xref="323962..324579" CDS complement(3963..4580) /gene="" /product="thymidylate kinase-like protein" /translation="LIIAFEGIEGSGKTSHLEATKKYLEKQGYGIITFGLQKSKLLGE RITQVKRNIVFERRTLFLAYVTDLADQIENYVNPSIDSGFIALADGYTLTLTSWGLTR GLEKEWIDDVLSILPKPSVSLPLISTPDEIVRRIIKKRGYLDPLETGIDICIKEDTFE AYIDYINRFQEVLMSISSKENIIYTDKEFDEVQKEIVRRIVSITS" gene complement(4564..5205) /gene="" /locus_tag="" /db_xref="324563..325204" CDS complement(4564..5205) /gene="" /product="dTMP kinase" /translation="MKGLLIAFEGIDGSGKSSQAVLLKDWIEMRRDVYLTEWNSSDWI HDIIKEAKKKNTLTPTTFSLIHATDFSDRYERFILPMLKSGFVVICDRYIYTAYARDV VRNVDFNWVKKLYSFAIKPNFTFYIRVTPEVALERIKKAKRKIKPQEAGIDILGELPL EEGFLKYQGMVVEIYDKIAKEESNFITIDGNRPLKDVQMDIRKILGEYIDNSL" gene complement(5202..6458) /gene="" /locus_tag="" /db_xref="325201..326457" CDS complement(5202..6458) /gene="" /product="Ppx/GppA phosphatase" /translation="MISAVIDCGYNSFRMVIYQVFRNGTFRMIGSSKSYVRIGEGLKE GDIISEEKVAKAERAFMIFKRILNGVNVNEVKIVATSAFRYASNGNEVRYRLSKIIEN EVRVISGEEEGRYAALGILNTLPISEGVFFELGGGSLEIAEVSSGNIIRVHQLPIGAL KLVNLPEREIRKKVSDELSTTNIKKANVIVGSGGNVRALAKLDLKLSSFPIKSIHGYS LSSKQISKYASLLPSLDIDSRQSLPGISKERALTIHSASVIIDELVKYFTGSYIVVSL FGMREGVLTEGKSLDKMSWLEEISYSNAIDPPPIEIFKEVISEVDSKYSFYVASSALL SLIFKMVGYFNPFRACYRFIKESVLPGFTLNEALLVGLICEAAGGKVKKKQAKLLKED ITKKEILSFGNIVKNSIDKYIAGVRL" gene complement(6459..6944) /gene="" /locus_tag="" /db_xref="326458..326943" CDS complement(6459..6944) /gene="" /product="phosphohistidine phosphatase SixA" /translation="MITLILVRHGDAEPQVDGKDDKDRRLVKKGVKQMRRVANFLEEL GFNVDRIISSPYLRAYQSAEVILEELYDNDSEKKVETLDDLTPDKEPSLFLEKLKDFA DNSTILVVGHEPYLSNFVKAISGGNVEIKKGGVVIVDYDLKEGRGVLKTLLSQKVLKL I" gene complement(7626..8519) /gene="" /locus_tag="" /db_xref="327625..328518" CDS complement(7626..8519) /gene="" /product="thiamine pyrophosphate domain-containing TPP-binding protein" /translation="VSSLVTPKRIPKFYRGNAACPGCPIPKELDVLLEVLGNKTVLVV PASCTTIIMGDTSGMPSTVPVIHSAFGAPAAIASGIVRALRTRGDKDVIVTVWAGDGS TGDIGFASLSGAAERNEDILYVCYDNEAYMNTGIQRSSLTPKGAWTTTTPEGKREYKK PLPFIIAEHKVPYVATASIAYIYDYEAKVRKAKQIRGFRYLHLLSPCPPGWRFDSKLT IDTAKLAVETGVWPLFEIENGEFRLTSVSKTLLDKKNRKPVAEYLKLQGRFKQLTEEE IKGIQEEIDEMWEEIKKLVKK" gene complement(8516..9673) /gene="" /locus_tag="" /db_xref="328515..329672" CDS complement(8516..9673) /gene="" /product="pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein" /translation="MQVLKRKALALVGNHAVAYAVKQSKPQVLAVFPITPQTTMLEKI SEYIASEELNAELIKVESEHSALASIYGAALAGARVFTATSSQGLLYMTEMIYWAGGQ RVPMVAAVATRAIAEPWSIWDDHQDFLSKRDAIWIQMMAENVQEAYDMTIQAFRISED ERVILPVMMGFDGFILTHTMERIEVLEDGEVDNFLPPRQFNLIDFSDPIGVGPIATPE NYIKYRYEAMKAMERAKGVIEEVMNEYERISGRKQNGLVECYKCEDAKYVFVTMGAWS GDCKVAVDRLRDAGVEAGLLKIRVFRPFPKEKIEEYLRSMKGVIVLDRAYSYGSGGIL ANEIKATLYGYRVPVYSVIAGIGGKDVRPRHFQKVIEDLINDNLEEERWLL" gene complement(9677..9943) /gene="" /locus_tag="" /db_xref="329676..329942" CDS complement(9677..9943) /gene="" /product="pyruvate ferredoxin/flavodoxin oxidoreductase subunit delta" /translation="LIKIPMGVPVARPRIGSAGKTGLWRVEKPVVDYNKCTKCRLCVI YCPENTIDLLENLYPQIDYDYCKGCGVCAQVCPPKAIDMVREVK" gene complement(9936..10484) /gene="" /locus_tag="" /db_xref="329935..330483" CDS complement(9936..10484) /gene="" /product="pyruvate/ketoisovalerate oxidoreductase subunit gamma" /translation="MTLIELALRGRGGQGIVTAGELVTKAMVLEDKYAQSIPFFGGER RGAPVVSFLRLSDKPILLHREVYNPDGVAIFDTSLIQIINVTEGLKENGFLLLNTNTP KRIWKSEYIVDATSIAKELGLVVAGWAVVNTAMIGALVKILGQPSLHSLEETVKEEFP GKIGELNAEAVEMGYKGVKRVD" gene 10661..10837 /gene="" /locus_tag="" /db_xref="330660..330836" CDS 10661..10837 /gene="" /product="carbon monoxide dehydrogenase, large chain (CutA-1)" /translation="MIQEHLPLITGKGSYIDGISPKNVVYLSVVRSPIARGIIKNISK PSLGQISLMGSKFI" gene complement(10944..11818) /gene="" /locus_tag="" /db_xref="330943..331817" gene complement(11876..12337) /gene="" /locus_tag="" /db_xref="331875..332336" CDS complement(11876..12337) /gene="" /product="hypothetical protein" /translation="MPNEGIKLIFSLQTNLSFLIRTTEGKLTVLIRNAKNKYKSSTTL IIMLEEWIKQLADALDKFVAGEQLTEDERIMVASLIYATLKHLKDFDEANEKLKEVEE KCNKNLDELEKKLDELRKELDKKEVEVKEKLKTLDNLIKIMEVNPRLLPKN" gene 12321..12743 /gene="" /locus_tag="" /db_xref="332320..332742" CDS 12321..12743 /gene="" /product="hypothetical protein" /translation="MPSFGIMTDIVTEKLKEELRKKLGREIPNVLVEFVNYLPPQVLA YVRANDYTIYVNYEQYMRAKRMGYEYEYLYVILLHEYLHVVGIADEREVRRIDLEMVR DKFGENSTAYKIALNLADPRDIYLNESQRLGGKPNTFM" gene complement(12975..13953) /gene="" /locus_tag="" /db_xref="332974..333952" gene 14386..15729 /gene="" /locus_tag="" /db_xref="334385..335728" CDS 14386..15729 /gene="" /product="FAD linked oxidase domain-containing protein" /translation="MDFTELKDIEQKVEEREDFSGEKVRPLGVFFPKDEDEVVRIVRF AKKNRLPIIPWGQGTSLTGAVSCDKNCILVDLSKMNKILEINDIDWYVRVQPGIKLID LFEELEKKGFMLPPDPASFFLCSVGGAVAESSGGMKGVRYGSFREWVLSLRVVLPNGE VIKVGEPLRKNRAGYDLVHLFVGSEGTLGIVTEIWLRIIPIPKRKMVMIAAMLKDFES AGEVIVGLRKNKILPELSEYVDADVVKALNKHLSANLKETEGGMLLISIEEDSVDDVL KVLEGKTVDIKIAEGEEAEKLYSLRSQAAIAVKAESNKVFYAEDIVVPVSKLPEAIRR LREIGEKYNTKFYVISHIGDGNLHPNIIIEDKVARENAFEEIARMAIELGGSVSGEHG IGVQKAKLMAEQIVKHNGVSVLDLMYHIKKLIDPDDIMNPDKYVELAYKFLTSRG" gene complement(15803..16198) /gene="" /locus_tag="" /db_xref="335802..336197" CDS complement(15803..16198) /gene="" /product="VapC-type toxin" /translation="MTSKGKYFDVNVFVYYLTGDRIYGERAKKWLSIKDDDKYTSIIT PFLLIIVLSRILGKSIKDYNFIKTAITALESLGIGYLELPEWSKIVENVRKYSIDIED SIHVTTALENGLEIVSNDEELKKKVNAEF" gene complement(16188..16430) /gene="" /locus_tag="" /db_xref="336187..336429" CDS complement(16188..16430) /gene="" /product="VapB-type antitoxin" /translation="VGKEFILTIDDRGRITIPKEVRELIKSKKLKLRVEGSKIILESI VVDIDKYYGIFRKDLENVDIDKMLNEALTEVLLNDK" gene complement(16572..16769) /gene="" /locus_tag="" /db_xref="336571..336768" CDS complement(16572..16769) /gene="" /product="hypothetical protein" /translation="MIVIGRRRVMVLDGGLSPCSLLLTFGESVRATSFLGQVVEAKFW AYAWTVHLANSVVGRALGIRV" gene 17287..18810 /gene="" /locus_tag="" /db_xref="337286..338809" CDS 17287..18810 /gene="" /product="methylmalonate-semialdehyde dehydrogenase" /translation="MFERDILTTHHFELPMGRVLEEVKENYGRLKLYINGELVDSKTD TIGKAYNPAKDEVIAEVPFSAKDEVREAIQSAQEAFEKWREVPITTRIQYLFALKNKL EEYSETIARIVVQNHGKTIQEARGDMRRTIENVEAAISVAYTLYKGEHLDQVSQDIDE TVVREPLGVFGIITPFNFPTMVPFWYLPFAIVLGNTVVIKPSEITPVPMDFIIKIFDE VKLPRGVVNVVHGAKDVVDEFLTNKLIQGVTFVGSTRVGKYIYENAGKSGKKAIVQAG AKNFVVVMPDADLNKTIPSVISAFFGNAGQRCLAAANLVAVGNIYDDVKRKFMEASKQ LKIGYGLDESVDMGPVVTKDAKKRIIGYIEKGIEEGAKLLLDGREAKVLDYPNGYFLG PTIFDEVTPEMTIAREEIFGPVASIIHLRSLDEAIDIINKSNYGNASSIFTTSGYYAR KFRREVNAGNIGINIGVAAPMAFFPFGGRKESFFGVLHGQIDSVDFFTDKKVVITRW" ORIGIN 1 tgaatattga acaatcctcc actacattaa ataaagttta tccctaaaac ctcttctgcg 61 aattgctaaa gcatttaaaa tcatcttgtt caaatcctcc aaaatggtat ctttacctta 121 acctctttgt ctttatgcat ttttcagcta tgatatctct gagtgactct cagtacttta 181 acgatttccc agagtagaag aactacctag tagttagatc tagagcttgt gaagtaaaaa 241 tttttacaat aatgtttaaa aaatttttat gctattccca tcctctccat cgaggcttac 301 aaatgtaaga tatttgattg tataattaaa tgtgatactt ttcataatat ttccttatta 361 ggtgatcact ttttatagat gatgaggaat agacgcacag actaataatg aggatttaaa 421 cgcacttgat tgggctcaat gcaatatcta atctatgaaa tagtacagcg tgagtttttg 481 tcataatgac tatactttaa actttttagg taataaactt aagtcttata ctaaatgagt 541 tatgcttgtc tttgaggttt tgagagatct cccaatctat ataggaacct aagtctgaag 601 aattaagtgg tgatatttca tttataagga ggttatagta ccagctccct ggtgtaactt 661 taattttcct ctcaacaata taagtatgtt atgaaatatg atgtaataat tattggtgct 721 ggccataacg gtctagtttc ctcaatatat ttggctcaaa aagggcttaa ggtattagtt 781 attgaggcca gaaataggcc cggtggaatg agcgacactg aagaatataa gggagtaaaa 841 tatagtaggg cgtcatacgt attaggtcta tttcctaaaa gaattcaaga ggaattgggg 901 gtagtttttc ctacagttga ctcagatgtt gctgacgttt tcgtcactga agatggaaag 961 gttgtgaata tatggagaaa taaggagaaa agacttgagg agtttaagcg actaggtcaa 1021 accaaatacc ctaaaatgga ggaattattg ttcaagatta aggagaagat tgaaaaggaa 1081 atgcaatacg ttaccaaacc accttccttc gaggattttg tgaaggcagt agaaggaact 1141 gaacttgaga tatttacaca accatctaga aagttcctaa atgaatatct agataaggaa 1201 tttcaacctt atttctcata tggatttatg tacgatttac cagcatatgt tctggcatat 1261 tactttagcc tagactggaa gatagtgagg ggaggaatgg gaaaaatagg agaaatatta 1321 atgaatagag ctaaacaatt gggtgttgac tttatattca atacaaaggt gaatgagata 1381 atcataaagg ataacgtagc aactggtgtg agaaccaatg ctgacaaaat tgttgagagt 1441 aaaatagtta ttaatgctgt aagtccagtt ttgctgaaca agttgaccaa cggattactg 1501 aaagtttatc atccggagtt caggcctggt tggaagaggg atactttaat attgagggaa 1561 ttaccaaatc taccggatta cgtgagaaat catccagata cgttatttac gctaccaata 1621 ggtgaagtta ctattccttc aactgttgat aatagcctag gaggtcatgt gatgacaatt 1681 atgggtagtt atgaagaggc taaagagttc ttcccagact tggaaaagaa ggtagtccat 1741 gttgatagat tagatgctta taaacttgag agagaataca atgccccctt cggagatatg 1801 aatcatatgc ccatgtatac tgaatacttg ttcgacggta gaccagttaa aggttgggga 1861 tacactactc cggttaagaa cttgtacgta actggttctg gaacttaccc aggaggacaa 1921 gttactggag tacctggaag aaacgctgca atgaagatta taactgattt aggtatctaa 1981 taatgttgtt tactattggt cattcaaata gaagcttaga agattttatg gaaatattaa 2041 ggaagtataa cgtggaaata ttaatagatg taaggagatg gcctaaaagt tctagatatc 2101 cacactttaa caaggagaat ctcaaaaagg ctttagaaca aagtggtata gaatatttat 2161 ggaaggaaca gttaggagga tataggaaaa tcggaaaaga cgttgaagac atagatattg 2221 gtaaatgctt taagagcgag ggttttagag cttatgcaat ttacattcta actaacgaaa 2281 gggttatgga ggcattagag gatattagga gaattaataa gataaaggtg atcatgtgct 2341 ctgagaagtt tccttggaat tgtcatagaa agataatttc tgactggttt ttagctaggg 2401 gagatgaagt agtacactta atagaaaagg aaagcactat caaacataaa ctcactacat 2461 gcgcagaaat tgtgaaaaat aatttaaact ataaataatt tagctaaatt caactaattt 2521 ttaatattct tttagcgtta tctctcatta tcttctcatc ctttaaaaca ttatatactt 2581 gataggcgta ttcagctaaa tcttgcccct taaatgctgg gaaatcactt ccgtaaatta 2641 tcttatctga aatttcgtgc aatctaggta atactttcaa tatgttctta gggggaatag 2701 acgagatctc taggaacacg tttcgtgtaa aacgagccat gtggaatgca gtattgtacc 2761 atagtggtct ccctgcatgt gctaggatta tcctaagttt cgggaaatcc ttagcaacgt 2821 catcggcgta aatcggatca gcatatttat ttctactttc tactcctata cttgttccag 2881 tgtgaattag gataggtaaa tcgtgatctt cagcgaattc atatacgtaa agtagttgct 2941 ttagtcctcc ttcctcttct ctatacgcat taggcttgaa cgcatgatgt acggggtgta 3001 gcttaattcc tataatacct aacgaatact gtttatctaa ctctctccta acatcacatc 3061 tccacgggtt tacttctccc cattgcagat aaagatctgg atttctcttt ctctcctcgt 3121 aatcgatata gaaaccatca taacagtcat cactatggca tggatgtgag ggaacaagaa 3181 ggattttttc aatttcgaca aactcattct ttaaagttat acttgtttcc tcaacattct 3241 ctaagaattc cttgcagtgt tcaggaattt ttctagcata tatgtgataa tgaacatgag 3301 catcaataac ttttatcatc aagataggta tgtttcattt ctattattaa tatctatctt 3361 tgagtttgaa atgatgaaac tcgtcttgag acgctatgat ctttagtatt accctcttag 3421 cttcttcctt gaactgattt acgtttatat ctggaggagt tactcctcta catctcattt 3481 ttagtatctc atctcttata tcccccattt tcttggcaaa agccttaatt tccgtggtgt 3541 cgtaaccaag agcctcaact agattcctag tcactcttac gcttttcctt aattcatgaa 3601 aatctgtcac gtcttgtatt tgatgtagag aggtgagaat tctattatat atgactagtc 3661 tggcaccata tatgttatta ttgacaaagc aaattttaag tcctctaact tcctttacag 3721 ccctaatggc tagtctattt ctttcttcat taattatttc gcagatatcc atgtctctga 3781 cctttcctaa tttgctaatt aactctttcg ctaagaatag acactccacg ttttcgtata 3841 ctggataaag agcatatagt acatcgaaat actttctcac cgccacccta atatcgtgaa 3901 tttcctcaac gccaatacca tttatttgca aggccttttt caactgtaga ttaaggtaat 3961 tctcaactcg tgatactgac aattctcctc actatctcct tttgtacctc atcgaattcc 4021 ttgtcggtgt atattatgtt ttccttggag gagattgaca ttaaaacttc ttgaaaccta 4081 ttaatgtaat ctatgtatgc ctcaaatgtg tcctccttta tacagatgtc tattccagtt 4141 tctaatggat ctagataacc tcttttcttt attatccttc ttactatttc gtcaggagtt 4201 gatattagcg gtaaggaaac tgaaggtttt ggaagaattg agaggacatc atctatccat 4261 tctttctcca atcccctagt taaaccccat gaagttaatg tgagtgtata accgtcagct 4321 aaagctataa atccagaatc tattgatggg ttaacgtaat tctcaatttg atcagccaag 4381 tctgtgacat aggctaaaaa taatgtcctt ctctcaaata ctatatttct cttaacttgc 4441 gttattcttt ctcctaataa ttttgacttc tgtaatccaa atgtaattat tccgtatcct 4501 tgtttctcca aatacttttt tgtagcttct agatgagatg ttttaccaga tccttcaatt 4561 ccttcaaagg ctattatcaa tgtattcacc caaaatcttt cttatgtcca tctgaacgtc 4621 ctttagtggt ctatttccat ctatcgttat gaaattgctt tcctctttag ctattttatc 4681 gtaaatctct acaaccatac cttgatattt taaaaagccc tcttccaatg gaagctcacc 4741 caatatatca attccagctt cttgtggctt tattttcctc ttagcctttt taattctctc 4801 caaggcgact tctggtgtga cccttatgta aaaggtaaaa ttaggcttta tcgcaaagga 4861 atacagtttc ttcacccaat taaagtccac gttcctaacc acatctctag cgtaagcagt 4921 gtatatgtag cgatcgcata taacaacaaa tccactttta agcattggca aaatgaacct 4981 ttcataccta tctgaaaaat cagtcgcatg aataaggcta aaggttgtgg gtgtgagcgt 5041 attcttcttt ttagcttctt ttattatatc gtggatccag tcagatgagt tccactcagt 5101 taggtaaacg tctcttctca tttcaatcca atctttgagt aataccgctt gactagactt 5161 accagaacca tctataccct caaaagctat taacaaacct ttcataatct cacaccagct 5221 atgtacttat caatactatt cttcactata tttccaaaac ttaatatttc ttttttggta 5281 atatcctcct ttagtaactt agcttgtttc ttcttaactt tcccaccagc agcctcacaa 5341 atcaaaccaa ctagtaacgc ttcatttaga gtaaaaccag gtaaaactga ttccttaata 5401 aatctataac aagccctaaa tggattgaag tatccaacca tcttgaagat taacgataat 5461 agagctgatg atgcgacata gaaagaatat ttgctatcta cctcacttat aacttcctta 5521 aagatctcaa taggtggagg atcaatggca ttagaatacg atatttcctc caaccaactc 5581 atcttatcta aactcttacc ttcagtcagt actccctctc tcataccgaa tagggagaca 5641 actatataac ttccagtgaa atattttaca agttcgtcaa taataactga tgccgaatgt 5701 atagttaaag ccctttcttt acttattccc ggaagggatt gtctactatc aatatctaga 5761 gaaggtaaaa gggaggcgta tttactaatt tgtttagaag agagcgaata accgtgtatt 5821 gacttaattg gaaaagagga taacttaagg tcaagtttag ctagtgctct aacgttacct 5881 ccagaaccaa ctatgacatt tgctttttta atgttcgtag tagagagctc atcggatact 5941 tttttcctaa tttccctttc tggaaggtta actagcttca acgctccaat tggcaactga 6001 tgtactctaa ttatgtttcc cgaactaact tcagctattt ccaatgatcc tccacctaat 6061 tcaaagaata ccccttcaga aattgggagc gtgttcaaga tacccaaggc agcatatctc 6121 ccttcctctt ccccggaaat cactctgact tcattttcta ttattttact tagtctatat 6181 ctaacttcgt taccattgga cgcatatcga aatgcactag ttgcaactat tttaacttca 6241 ttgacattta caccgtttaa tatcctttta aaaatcataa aagccctctc tgccttcgcc 6301 accttttcct cagagataat gtctccttcc tttaatcctt ctcctattct aacatatgat 6361 ttagaggaac caatcatcct gaacgttcca ttacgaaaaa cctggtaaat taccattcta 6421 aaggaattgt agccgcaatc tataactgct gagatcatct aaatcagctt tagaactttc 6481 tggctgagga gagttttcaa aactcctctc ccttccttca gatcataatc tacaattaca 6541 actccacctt tcttaatctc aacgttacct ccacttattg cctttacgaa atttgacaga 6601 tacggttcgt ggcctacgac gagaatagtt gagttatcag cgaaatcctt aagcttttca 6661 agaaatagag agggttcctt atctggagtt aagtcatcca aagtctctac ttttttctcg 6721 ctatcattat cgtatagttc ttctaatata acttcagcag attgatatgc tcttaagtat 6781 gggctggaaa ttattcgatc tacattaaat cccaattcct ccaagaaatt cgcaactctc 6841 ctcatttgct ttactccctt tttcactagt cttctatcct tatcgtcttt accatcaact 6901 tgcggttcag cgtctccgtg cctcaccaag attaaagtta tcatgttcta taataacgtc 6961 tcagaatatt taagcatttt tgtatagtag atattcaaaa tctcaattct ccttatcata 7021 tgtggtcatg gcactttcta cgttcgagtt gggaaaaatc aaatggattt ataggtaaat 7081 aattctaaat gtttaactta attaggggtt aagggggcga aagtcccctt ccgtaaggta 7141 ggggatgaat agccccctta tagaaacctt tttattgcaa aaaatagata attcttaggc 7201 ctcggctgta agagctgggc cgtacctttg gtactggggg aacttacgcc tgtggagagc 7261 aaccctccgt aacccctctt ccacacgggg cattacagaa cggttccgtt cgatggaacc 7321 tccgctgtgg gtgaaggggg atcgaggttg ctctgagaag caggaaatcc ccatcgtgag 7381 gtggagatgc cctgttcgta agggcggggt agttcactag aaactcctaa ctcttcagat 7441 gagatagtta ttgcattcga tgaggtgcaa gagttatcct ttgcatctaa gcagttttat 7501 tttggggaac gtttacgcta gttaatttta actttgtctc aaaagtggat ggcgagtata 7561 agattgttga tccaatattg aatgagattg attcagttag tgttaaaaga aaaagaaaaa 7621 atattttact tcttaactag ttttttaatt tcctcccaca tctcatcgat ttcctcttgt 7681 atacccttta tttcctcttc agtgagctgt ttaaatcttc cttgcaattt taaatactcc 7741 gctactggtt tcctattctt cttgtcaagt agtgtcttac ttacactagt caatctaaac 7801 tcaccatttt ctatttcaaa gagtggccaa actccagtct caactgcaag tttcgcagtg 7861 tcaatagtca atttagagtc gaaacgccat ccgggcggac atggggataa taagtgtaaa 7921 tatctaaatc cacgaatttg cttagctttc ctcaccttgg cttcataatc gtatatgtaa 7981 gcaattgaag cagtagctac atatggtact ttatgttctg caattatgaa tggtaagggt 8041 ttcttatatt ccctcttacc ttctggagtt gtcgttgtcc atgcgccttt tggcgtcaag 8101 cttgaacgtt gaattccagt attcatatac gcttcgttat cataacatac gtaaaggata 8161 tcctcatttc tctctgcagc accgcttaat gatgcaaatc ctatatctcc agtagaacca 8221 tcaccagccc atacggttac tattacatcc ttatctcccc tagtccttaa agctctaaca 8281 atgccggaag ctatagctgc gggagcacca aatgcactat gtatcactgg gacagttgaa 8341 ggcattccac ttgtatctcc cattattatt gtggtacatg aggctggaac gactagaacg 8401 gttttatttc ctaaaacctc taggagtaca tctaactctt taggtattgg gcaacccgga 8461 caagcagcat tacctctata gaacttgggt atcctcttag gtgtaactaa actactcaca 8521 acaaccacct ctcctcttcc aaattatcgt tgattaggtc ttcaatcacc ttttggaagt 8581 gacgtggcct aacgtccttt ccaccaatac ctgctattac gctgtaaact ggtactctat 8641 agccataaag tgtagctttt atctcatttg ctaaaatccc cccagaacca tacgaataag 8701 ctctatcgag aactattaca cctttcattg accttaagta ttcctctatt ttctcctttg 8761 ggaatggtct aaataccctg attttgagca atccagcctc aaccccagca tcccttagtc 8821 tatccacagc aaccttacag tcaccactcc acgctcccat ggtaacgaaa acgtatttgg 8881 catcttcaca tttataacac tcaactaaac cgttttgttt ccttccactt atcctctcgt 8941 attcattcat tacttcctca ataacccctt tagctctttc catggccttc atagcctcat 9001 acctatactt gatgtaattc tctggagttg cgattggtcc aacaccaata ggatcagaga 9061 agtcaattag gttaaattgt ctaggcggta aaaagttgtc aacctcacca tcctctaata 9121 cctcaatcct ttccattgtg tgagttaata tgaagccatc aaatcccatc atgactggta 9181 agattactct ctcatcttct gaaattctaa acgcttgtat tgtcatatcg taagcctctt 9241 gaacgttttc tgccatcatt tgaatccaaa ttgcatctct cttacttagg aaatcttgat 9301 gatcatccca aatactccaa ggctctgcaa ttgccctagt tgcaactgca gcaaccatag 9361 ggactctttg acctccagcc caatatatca tctcagtcat gtatagtagt ccttgagaag 9421 acgttgcagt gaaaactcta gcaccagcca atgcagcacc ataaattgaa gccaacgcag 9481 aatgctcact ttccaccttt attaactcag catttaattc ctcagaagct atgtattcgg 9541 aaattttctc tagcattgta gtttgaggag ttattgggaa caccgctaaa acttgaggtt 9601 tagattgctt aacagcataa gcaactgcat gattaccaac taaagctaag gctttcctct 9661 ttaaaacttg cataattcac ttcacctccc taaccatatc tattgcctta ggtgggcaaa 9721 cttgtgcgca aacaccacaa cctttacaat aatcgtaatc aatttgagga tagaggttct 9781 ctaggagatc aatagtattt tctgggcaat aaattacgca aagtctacac ttagtacact 9841 tattgtaatc aactactggt ttctcaactc tccataatcc agtttttccc gcagatccta 9901 tccttggcct agctactggt actcccatgg ggattttaat caaccctttt caccccctta 9961 tatcccattt caaccgcttc cgcattgagt tcccctatct ttcccgggaa ttcttccttt 10021 acagtctctt ccaacgagtg taaggaaggt tgccccaaga ttttcactaa agctcctatc 10081 atcgcggtat taacaacagc ccatccagct acgactagcc ctaattcttt agcaatactt 10141 gtagcgtcaa caatatactc acttttccaa attctcttag gcgtatttgt gtttagtagt 10201 aagaaaccgt tttctttgag tccctctgta acgttaatta tttgaatgag tgacgtatca 10261 aatattgcaa caccgtctgg attgtaaact tctctatgta aaagtatcgg cttatctgac 10321 agccttagaa atgatacgac tggagctcct ctcctttccc caccgaaaaa gggtatggat 10381 tgggcgtatt tatcctctaa aaccatggcc tttgtaacaa gttccccagc agtaactatt 10441 ccttgccctc cccttcccct taaagctaat tcaataagag tcattttatc acaataataa 10501 tattcgactc gtaggaaaaa aagttgtcct aaaacgaaat ataataaaga tatttaacgc 10561 ggttgaacca gattattttt atatacagat taaaatatga tatttctcta ctgcgaaata 10621 tttgatgaga ttttattagt tagtttacgt aataactttt atgatacaag aacatttacc 10681 tcttataacg ggaaaaggaa gttatattga tggcattagc ccgaaaaatg tagtttatct 10741 tagtgtggtt aggtctccaa tagctagggg tataataaag aacatatcta aaccgagtct 10801 gggacaaatt agtttaatgg gttctaaatt tatatagtgt ttcaagattt ttaatctaac 10861 gctttagacc atagtaggtc gtgaatcgtg accctcgcta agaccgccaa gtggatcttc 10921 tcttccctga ccttatttat gatctacctt gtcctccttt tgatggagga gatcagagac 10981 tctgccttct cacgcttgaa atactcctcc aaatattcca gtgggttctt catgaacctc 11041 aatatcatct ccctcaacct tttccctcct ttgatcgtgg cgttagacct aggtatcaag 11101 tagacctcgg aatcaaggaa gtcatccagt gtagactttt tgtagtactt gtcagttctc 11161 aagaagtcct tgcacgccaa gatccctcag gacctcgagg gccatctcat aagcctctct 11221 ctcactctca agcgaataac cataagctac aatcaagtta ctgcctaagt caaagatgaa 11281 gaaggagtac acgaagtcct tcccttcctt catctcttcc ccagacttct ccctttcact 11341 cctgtaatgc ttggtcacta ctagggaata gcttgtcccg tctatgaccg cgtccatctt 11401 aaggccacta acggtctatg ggagcaggtt gtagagaatg acgaagacgt cagggtcgga 11461 gtgtagtctc tctactgtct tgtagcttat ctcctccttc gttaggttca gtagtgatgc 11521 cagttctgcg gtttccttgt tggataaccc taggtattcc ttgattatca gtatgtacgc 11581 cttctcttga ggggttaact tgctcttcct cccttgttct ttcttgatct tcacgaactt 11641 ccctgcttca tctatgtcct gccttaactc ttgaccgaac ctccttaatc tagctagcct 11701 cttcgctctc ctcagtgttc tccatcttac tgagcctact ttccttgtac aacttgatca 11761 agtcctctat tgactccttg aagtcgtcta agtccttctg agttaacttc ttattcatgt 11821 gttcataata caaaataaga tgtatctaaa gtttttgtcc cagagtcgct taaagttagt 11881 ttttaggtaa taatctagga tttacttcca ttatttttat taaattgtcc aaagttttca 11941 acttctcttt cacttccacc tctttcttgt ctaattcctt tcgcaattcg tctaatttct 12001 tttctaactc atcgaggttt ttgttacatt tttcttcaac ttctttaagt ttctcgttag 12061 cctcgtcgaa atccttaagg tgtttcagtg ttgcataaat gagagaggct accataattc 12121 tctcatcttc tgttaattgc tcaccagcca caaacttatc taatgcatcg gcaagttgtt 12181 ttatccattc ttcaagcatt ataatcaaag tagtagagga tttatattta ttttttgcat 12241 tccttattaa aaccgtcaat ttcccttctg ttgtgcgtat gagaaagctt aaattagttt 12301 gcaatgagaa gattaatttg atgccttcgt tcggcattat gacagatatt gtaactgaaa 12361 agcttaagga agaactaagg aagaagttag gaagggaaat tcccaacgtt ttagttgagt 12421 ttgttaatta cctccctcct caagtattgg catatgtgag agctaacgat tacacaatat 12481 atgtaaacta cgagcagtat atgagagcta agagaatggg atatgaatac gagtatttgt 12541 acgttatact actgcacgaa tacttacacg tggttgggat tgccgatgaa agggaggtaa 12601 gaaggataga tttagaaatg gtgagggata agtttggtga aaatagcaca gcgtataaga 12661 tagccttaaa tttggctgat cctagagata tatatttaaa cgagtctcaa aggttgggtg 12721 gaaagccaaa caccttcatg taaaaaagca tttcttttat tatttaatac gttttattta 12781 agtatagtga cttatctaaa ttgagaacaa aatgtttata tagaaaagaa agatttcctc 12841 ttgtggaaga gaaagtagaa atttatggta atgattatga cgagaagctt cctataatat 12901 ttgctgaccc aacttcttaa ctttacgggg gttaaggggg cgaaagaccc cttccgtgag 12961 cggtagaccc aaaatcacct ccttaaaaat aaatctatag tataaataag cgttttaatt 13021 acattaaatg taaaattctc tggattgaat aaatcaggaa ataaaagaat taataataat 13081 ctaaactcct ctctccccac ctcccccttg aatatggtat ataaggagta gagtacaagg 13141 gccagcacga agatcaacgt gcggaaaaca aacttagtag aactagtaaa tggaagaaaa 13201 gccttaatgt tcctataaga ggtctctatg ggacctctta ccttattgta caaatccaac 13261 acttccctct tggataggtc taggttagta gccctagcga agtaaacaag actcttcttc 13321 tttctcccca ctttttcctt gctgtacacg agaagcctga acttgacctg ctcatccctc 13381 ctatgcctct tactattagt tgtgtaatcc ccgtcaaact cctcgtacac cttcacgtcc 13441 ccaaccggaa cagcaattat gtatttaaac tgtgaaatga agttgagcac atcaacagta 13501 tagaaaccag cgtcaagagt tatcaacctt atcttgaatc ccattacttg ttcaacaaga 13561 gccttcacta tctcgtcctt agtcataccg ttcacttgcg gcaagtaaaa tcactttccc 13621 cttatacttg gttgttgcag ttgcgtagtt ccacgagttt cctttttcag agctcccgag 13681 ccctttcact ggtttcccat accacgtctt ggttgtccag tctattgaga gatctatctc 13741 attcactccc tttaatatct ccaaggatat tttcctagct ctttccaata gcttttcagt 13801 cacttccatc ccttgtttat ctacgtaatt cctcacggtc tgtggggata cgtcatacgc 13861 tctggacttg ttctctactg aatcgttcca caaacacgcg gagatgagag ttttcgctac 13921 ctcctctacc ttttcccctt ggaagttcaa catggaaagt aatttatatc ctatttgttg 13981 aattttggtg agggagacct ggtgttacca tcttcctatg tcacgtggta atacgccatc 14041 tccctcacct taaacccttt cttcaattga attctttata ctcttataaa tttctttatc 14101 ttttatcaat tcgatattat cctaccagaa atattttttc taatatgatt ttgggtctac 14161 cggtaagggc ggggttgttc acatgccaaa ctgatcaaat ctagaataaa cgattttagg 14221 agtaagccaa gtgagttaat aaggcctgaa aggataaaga ggaaaaattt aacttgccca 14281 taaaaacttt ttaattttga ggaataaatt tgatcattat ataagggaca aagctattca 14341 tttgcataaa aaatcctttt attaactcac gtataattgt ttattatgga tttcaccgaa 14401 ttaaaagata tcgagcaaaa ggtagaggaa agggaggatt tttccggaga gaaagtaaga 14461 ccattaggcg tattcttccc taaggatgag gatgaagtcg ttaggattgt tagatttgct 14521 aagaaaaata gattacccat aataccatgg ggtcaaggaa ctagtttaac tggagctgtt 14581 tcgtgcgata aaaactgtat actagtagac ctatctaaaa tgaataaaat tttagagata 14641 aacgatattg attggtacgt aagagtccaa ccagggatta aattaataga cctcttcgag 14701 gaactagaga aaaaaggctt tatgttacct ccagatccag caagcttctt tttatgctca 14761 gttggtgggg cagtagctga atcctctgga gggatgaagg gtgtaaggta tggttcattc 14821 agggaatggg tattatcttt acgtgttgtt ttaccaaatg gggaggtaat taaggtcgga 14881 gaaccattga ggaagaatag ggccggatat gatttggttc atttattcgt tggaagtgag 14941 ggaactttag gtatcgtaac ggaaatctgg ttgaggataa taccaattcc aaagagaaag 15001 atggttatga tagctgcaat gttaaaggat tttgaatccg ctggagaagt tatagtaggc 15061 ttgaggaaga ataagatatt gccagagttg tcagagtacg ttgatgctga tgtagtcaaa 15121 gcgttaaata aacacttgag tgcaaacctc aaggaaacag agggagggat gttattaatt 15181 tcaatagagg aagatagtgt cgatgatgtg ttaaaagtat tagagggaaa gacagttgat 15241 attaagattg ctgaaggtga agaggcagag aaattgtatt cattgagatc acaagctgca 15301 atagcagtga aagctgaatc aaataaagta ttttacgctg aagatatagt agtaccagtt 15361 tctaaactgc cagaagctat aaggagactc agagaaatag gtgagaagta taatactaaa 15421 ttctacgtta tctcgcatat aggtgatggt aatcttcatc caaacataat aattgaggat 15481 aaggtagcaa gggaaaatgc atttgaggaa atagctagaa tggcgattga gcttgggggt 15541 tctgttagtg gagagcatgg aattggtgtg cagaaggcta agttaatggc tgagcaaata 15601 gttaaacata atggcgttag tgtattggat ttaatgtatc atataaagaa gttaattgat 15661 ccagatgata taatgaaccc tgacaagtat gtcgaattgg catataagtt tttaacttct 15721 agggggtaga agtgctattt gatccttacc caaaaactga aagtagagat ttcttccata 15781 gggaaaacga aattccttaa cgttaaaatt ccgcattaac tttcttcttt aattcttcgt 15841 cgttcgatac aatctctaat ccattctcta acgctgttgt aacgtgaata gaatcttcga 15901 tatctatact gtattttcta acgttttcaa caattttact ccactctggg agttctaaat 15961 atcctattcc taaagactca agggctgtga ttgctgtttt aatgaaatta tagtccttta 16021 ttgatttacc gagtattcta cttaatacta ttattaataa aaatggggtt ataattgaag 16081 tgtatttatc atcatcttta atactaagcc acttcttagc tctttcacca tatatcctat 16141 caccagttag atagtagaca aaaacattta catcaaaata ttttccctta cttgtcattt 16201 aataatacct cagttaacgc ctcatttagc attttatcta tatccacgtt ctctaaatct 16261 ttcctaaata taccataata tttgtcaata tccactacta tagactctaa tattatttta 16321 gaaccttcta cccttaactt taacttctta cttttaatta gttctctcac ttctttaggt 16381 atagtgattc tacctctatc atcaattgtt aatataaatt ccttgcccac atatacccat 16441 ttaataaccc ccaaatataa actttttctt ttgcgttgct ttgttgatat cttcaattta 16501 ttttataaac atgatatgat ataaggagaa tttttcagca attaatattt atttcaacgt 16561 tattctcaag ctcataccct aatacctaga gccctaccga ctacagaatt agccaagtgg 16621 accgtccatg cgtaagccca gaacttggcc tcaaccactt gtcctaaaaa acttgtagcc 16681 ctaacagatt ccccaaaagt taacagcaga gaacaaggac tcaatccacc atctaacacc 16741 ataacccttc tcctccctat aacgatcata tcctaacttc ctaaactccc gcacagcttt 16801 acgtctagaa ggataaccgc gcttagtaaa agcgtccttt ctgagaggaa ctacaatctc 16861 aactctggtc ttgtagacct cgttgacgtt atatgtctca tagtctttta atatttgcaa 16921 aggagtaaaa gggttattaa cttagtgggg atgttgggaa tgagtgagtt aaggggtaac 16981 tggctatatt ttgtattgac aaaagctata ttctcttcgc aattactaag aaaaacggac 17041 tataatatgt taagctactg atctatggta aaaattcaaa tttatttcaa caactactgt 17101 taattatctt ttatagttct cattacaaac actttattga attctttatt taatcacaat 17161 ggtatttact atagattgga gagtttgaaa agaaatacat aacaaggtca aggatttaga 17221 attatctttt attttttgct taaagagaac tcactatgca taatcttttc attatctgtt 17281 tgaaacatgt ttgaaagaga tatattaacg actcatcatt ttgaattacc tatgggtagg 17341 gtattggaag aggtaaagga gaattatgga aggctgaagc tatatataaa cggtgagctt 17401 gtagattcta aaactgatac aataggtaag gcatataatc cagctaaaga tgaagttatt 17461 gctgaagtcc cattctcagc taaagatgaa gttagagagg ctatacaatc agctcaagag 17521 gcatttgaga agtggagaga agtcccaata actactagaa tacaatacct cttcgcgctt 17581 aagaataagt tagaggagta ttcagaaaca atagctagga tagtagttca aaaccacgga 17641 aagaccatcc aagaggccag aggggatatg aggagaacta tagaaaacgt tgaggctgca 17701 ataagtgttg cttacacttt atataagggt gaacatctag atcaagtatc tcaagatatt 17761 gatgaaaccg ttgttaggga acctttagga gtttttggaa ttataactcc attcaatttc 17821 ccaacaatgg ttcccttctg gtacttacca tttgcaatag ttttaggaaa tacggtggtc 17881 attaagcctt ctgaaataac tccagtacca atggatttta ttattaaaat ttttgacgag 17941 gtcaagttac ctagaggtgt tgtaaatgtc gttcacggtg ctaaggatgt agttgacgag 18001 ttccttacga ataaattaat ccaaggtgta acattcgtag gttcgacgag agtaggaaag 18061 tacatttatg aaaatgcagg gaagagcggt aagaaggcca ttgttcaagc aggagctaag 18121 aactttgtcg tagtaatgcc agatgctgat ttaaataaga caataccctc tgttatctca 18181 gcgttctttg gcaatgcagg gcaaagatgt ttagcagctg ctaatttagt agcagtaggt 18241 aatatttatg acgatgttaa gaggaagttc atggaggctt caaaacaatt aaagataggt 18301 tacggtttgg atgaaagtgt agacatgggc ccagttgtta cgaaagacgc taaaaagagg 18361 ataataggat atatagaaaa gggtatagaa gaaggagcaa aactattgtt agatggtagg 18421 gaagcaaaag tacttgacta tcccaatgga tattttctgg gtccaactat atttgatgaa 18481 gtgacaccgg aaatgacgat agcaagggag gagatatttg gaccagtagc gtcaataatt 18541 catctaagaa gtttagatga ggcaatagat attataaaca agagcaatta cggtaatgcg 18601 tcatcaatat ttaccacaag tggttattat gctagaaagt tcaggcgtga ggtcaacgcc 18661 ggaaatatag gcattaatat aggtgtagct gcgccaatgg cgttctttcc atttggaggc 18721 agaaaggaat ccttctttgg cgtactgcat gggcaaatag atagcgtaga tttcttcaca 18781 gataaaaagg tagtaataac aagatggtaa //