LOCUS NC_017243:20 23354 bp DNA linear BCT 04-SEP-2013 DEFINITION Brachyspira intermedia PWS/A chromosome, complete genome. ACCESSION NC_017243 SOURCE Brachyspira intermedia PWS/A chromosome, complete genome. COMMENT locus start: 1698000; locus end: 1721353 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.369134; n0_4mer:D = 13.980585; n0_4mer:PS = 23.840490 FEATURES Location/Qualifiers source 1..23354 /organism="Brachyspira intermedia PWS/A chromosome, complete genome." gene complement(34..834) /gene="" /locus_tag="" /db_xref="1698033..1698833" CDS complement(34..834) /gene="" /product="ankyrin repeat-containing protein" /translation="MKKIVLMAVLCTLFSFNALYPELSKDEKEFVAYIANGNKEEVLD FLNNKKVNINLDIMDGATPLILSIIYKQDEIAKLLIEKGADLNKKEKESGATPLILSI LYEQYEIAEILIEKGANVNIKDNSGFTALIHAIQREKTDLSKMLIEKKSDVNTKVSFK TDGLYLKDFTPLTFNVDTEVAELLIKSGANINTRLSIKDDSRNIQLENITPLMWVIFD YNTEIAELLIEAGADLNAKDKNGNTALDYARYRNDSKIEKILIENGSK" gene complement(1058..1756) /gene="" /locus_tag="" /db_xref="1699057..1699755" CDS complement(1058..1756) /gene="" /product="ankyrin repeat-containing protein" /translation="MKKIVLMAMLYTLFSFNALYPANSENEALFLSYIASGDIEEVSN FIDNKKININARIKNSATPLIFSIIFKQDEIAKMLIEKGSDLNIKDNLGFTALIYSIM YNRTEISKILIEKKSDVNTKVSLNENGVYMKNVTPLILNENKEVAQSLINASADINIK FSFQDAGENIKLENITPLIWFIFTDNSEIVKLLIESGADVNAKDKSGKTALDYAKDKN NPKIEQLLISKGAK" gene complement(1992..2690) /gene="" /locus_tag="" /db_xref="1699991..1700689" CDS complement(1992..2690) /gene="" /product="ankyrin repeat-containing protein" /translation="MKKIVLMVVLYTLFSFNALYPANEETEAQFFLYIGSGNIEEVSN YIDDKKININAKLDDGMTPLILSIVYKQDEIAKMLIEKGANLNIKDKSGFTALIHSIM KNRTEVSKMLIEKKADVNIKLSLNENGIYMKNFTPLILNEDKEVAQSLISAGADINIK LTAKYPGQDLKLENATPLMWFILNDNTEIAQLLIEAGADINAKDKSGKTALDYAKEKN NTKIEELLIAKNAN" gene complement(2977..3612) /gene="" /locus_tag="" /db_xref="1700976..1701611" CDS complement(2977..3612) /gene="" /product="cAMP-dependent protein kinase regulatory subunit" /translation="MDNNLSSHTKKYNTDDVIFLEYEKGDKFYLVQSGSVKITKVIKD VEKLLDIVYAGEFFGEMAILEDTTRSASAIANEPTVLLELRKENFQSILANNTVMALK LSKTFAKRIFDAKRRLLILQLNETDLRVYDCLLLLAELQNIPRDHYYEPQELNATIND IANWCGVKVVDVQKVLNTLVKTGKIDIRTNTIYVKNLKEIQRQIDLKRKKS" gene complement(3638..4624) /gene="crp" /locus_tag="crp" /db_xref="1701637..1702623" CDS complement(3638..4624) /gene="crp" /product="cAMP-binding protein" /translation="MQTRVYKAGSIVYFTGDTSDRVYILKQGQAQSIFLSEETGYETR ELINIGEFFGVKSILGTYPQEDTVQCLTDCVVIIITYEEFESLIEKNKPIIIKMLKVF SNQLRRINKRVRELVENDISEEGQDPLEGLYGIGEFYFKNKKYRNALYAYKRYIQYAD EDSAFYNTVKEKIEECKEELDITDDSDIAPPVSNAPASAPKTQAKAAINDPAYNKAVE LYNNNDYVNSLKAFNNLIKSPDTAVAENSIFYMGKCYYNINKYDNASTVLLSAIKKYP KSQNVKEAILFLAKSCEGSGNKTKAKAYYQKVISMPPMDNFSKEANASISRL" gene complement(4738..5325) /gene="" /locus_tag="" /db_xref="1702737..1703324" CDS complement(4738..5325) /gene="" /product="flavin-nucleotide-binding protein" /translation="MRRKDFIFEDKEEIYSMLNSIEFGVMALPDDIPYAVPISFCYKN NEIYFHGAMAGRKYEILKNNPKVSFSASKPYSYIPSEFLNGKMIPTQFFFSVFIEGKF ETIDDISRRKEILYEIVKKYEPNNDNLSIDNKMFDYAQNNMLIGVIKIENLTAKAKFG QNMQDEEITIIIDDLNTRSKDIDIETVDMINKLRK" gene 5464..7356 /gene="nadE" /locus_tag="nadE" /db_xref="1703463..1705355" CDS 5464..7356 /gene="nadE" /product="D+ synthetase" /translation="MKIAVSQLEIIPSMPCDNTVRIISFISKAKKENADIVIFPELCV SGYMIGDMFESEGFIKECEELGEEIIKSSNGIYVIFGNIASDKNKKNFDGRIRKYNAM FVAKDGKLIHNNTTEYPFIIKSLLPNYKEFEDPRHFFSLKDLAFENNADIKEYLKPLE IECNGEKIKLGLTICEDAWSKNYTFSPMDIINSNKDVDLFINISSSPYTLVKDAKRHS MYGEIASKHNTPLIYINNVGIQNNGKTVYTFDGRSSVYDNKGNLLLTGKRYEEDLYFI DIDVKNKAFGKTIEIKEENEYKLIYETVIYGIRKFMKSIGINKVVIGVSGGIDSALSS VMYVNAIGKDNVLLVNMPSKFNSDTTKNLAKTLSDNLGCAYMVVPIQESVDYTVKQLE SSPIIKDGKEDHLKLSSFVIENIQARDRSSRVLSAIAASFGGVFTCNANKTETMVGYS TMYGDGAGFFACLADLWKYQIYGLANYVNKEVFKKEIIPEGTINIVPSAELSTAQAVD EGKGDPIKYDYHDYLFKFLMESWNRAILEDILELYIEGNLEEKIGCQKGTLKKYFKNG AEFVDDLERWWKQYMGMGISKRIQAPPILAVSRRSFGFGNRESQNRIYYTAKYLNLKN KIFEIN" gene 7489..9417 /gene="tar8" /locus_tag="tar8" /db_xref="1705488..1707416" CDS 7489..9417 /gene="tar8" /product="methyl-accepting chemotaxis protein" /translation="VAATIIDNNIRQDILDYSAILETTVKDINSFLEEVGRVYSFIGE KFPMIEQEMKNENEKANKLLSYFTNKEKGEKNFSNDLDENQEDFFRSFDRMQSFISQD NELSDSLVEDVGRTSNIMDSIEQIRMLADQIKVYSLNAIIISSKYGAGGKAFGEISKN IIKMSETSNEQADQMNRIGKELFVRFESFKTEILKTNELQRQNFTIMREQLDKEHNNM VNSFAVFSNIISDIISRVDNTYDFIFEVMMVLPREDIVRQQTEHIIESMNSIVYENRN FIEYYGKEVETMDAADLEKEENQSLEHKLLDLLTFDDVVLTLIIENFKSIHEEIDLTN SDIYKSLKGLKDALTDITLDRTTIVEYMIGGESGKSEFPFTVSESLFNEYMGFIKLYL ENFKLFLTNKYRISDSNIAIIDSIEELESMFLETKNIAKTFNSINFLAKIELEKNSDI FNNSQTFSIESVESIATNITETVDGCLEQFHNIKSAIFSSINKFKSNINQQSSEHSFI ESMTDSVSKRLDESKYIINNNIKRLDSYADELFGLIDKTLIDLSSLSTLLTKINEIIE IFNSMRNVIRDKKNEYYNLLGIENWKIESDKYLDIVNSYTIKKERAIANSILSGEDAP NVDISIDVGADSGDFTMF" gene 9442..9705 /gene="" /locus_tag="" /db_xref="1707441..1707704" CDS 9442..9705 /gene="" /product="anti-sigma-factor antagonist" /translation="MSVIEINDNLNIRTMSKYFKNVIKSANYNEDMTVKFNCEGDAHV DLAGLQILYAMKKELAKNQKNLIVEGMDNLFVEYLKIINDKNN" gene 9725..10093 /gene="" /locus_tag="" /db_xref="1707724..1708092" CDS 9725..10093 /gene="" /product="chemotaxis response regulator CheY" /translation="MAKTILIVDDSNTARASVEYTLKKGSYTVVSADDGTTGLEVLGK TPNVDMIITDLNMPKMDGIEFIKHVRKVDQHKYTPILMLTTESQDEKKMEGKAAGASG WLVKPFNPTQLLDVVKRFLN" gene 10232..12328 /gene="cheA" /locus_tag="cheA" /db_xref="1708231..1710327" CDS 10232..12328 /gene="cheA" /product="chemotaxis histidine kinase CheA" /translation="LEDNKSDEDLLNKIFRSAHTLKSSAGTVGFTTMSELNHVAENLL EKVRSGKLDVTPQMITVLLEFLDTVKLMLQNIVDGKSETEGVTNIDSLKAKIKAIADG NDVSTAAAAPKASPEPKKEEPKKEEAKATETKPEEKKEDTKADESSATSGGENSFHIE MGFKATIFDNGIDPLMFLNDLRAIGTISNLKIECNSLPTILNLEDPYVCYTQFSLDFE TNAPEEQVQNIFLFVIDDNDINIINTKAEIKDDDEANKAVETKEEQPAKEEAKEDTAA KPEEKPAETAAAASKPAAAPKTGTKVQAPSTVRVDTRKLDSLMNLIGELVIAQSRIMQ LTQSLDIDNGLKEAVSSMDRTSRQIQEEVMNIRMMPIGPIFTQFHRYVRDLNLELNKE VKLVLKGETTEIDKNMLEQLSDPLKHIIRNSMDHGIEKTKEERIARGKPEYGTITMSA AHQEGHVVIEVSDDGNGLNKEKIFNKAVEKGLLSKDGKYSDIEIYRTIFSPGLSTAEK ITDISGRGVGMDVVRANVEKMKGKIEIKSAEGQGSTFIIKLPLTLAIIEGITFALGKQ IYIMPLISIIEQIKVKNEQVKPFEGKGEMIKIRDEYLPLIRLHKVFEIDTQVENIDDG IVVVVEAGYRKCAIFVDELLDQQQVVIKSLDSAFSKHAGIAGGTILGDGRIALIIDIQ GLVNMSLQGKINNGVK" gene 12340..12870 /gene="cheW" /locus_tag="cheW" /db_xref="1710339..1710869" CDS 12340..12870 /gene="cheW" /product="chemotaxis protein CheW" /translation="MLDNQKINAANIPQVGGTSLEHDENISIEPSQQFLVFKIDNEEY ALDVLSIEGIVGVTNITPVPGSPKFMRGLMNLRGNILHIVDIRIRFGLDRRDDHSIED DVIIVISTTNRKFGILADMVSDVITVYESQMTETPIDNMRGLQISNVIRLENKIIMVL PIEEIIKSNETTNQTV" gene 12889..13740 /gene="cheR" /locus_tag="cheR" /db_xref="1710888..1711739" CDS 12889..13740 /gene="cheR" /product="chemotaxis protein methyltransferase CheR" /translation="MEDMNEHMPALSDAEFNELVKIIYDKTRIQMTSHKRALVTSRLS KRLRALKMDSFREYIDFVKNAKDEELTNFVNAVTTNKTDFFRENKHFEYMKSTFLPDW EKNFKAGKVKNLRIWSAACSTGEEPYTIQMTLHEYFGANYDKYDIKVLASDIDTNVLA HGRAGIYKEESVEPIQENILRKYFLKGTGDKEGLYKVKDILKKNLFFRQLNFKDEDFD IHTQFDLIFCRNVIIYFDKEFQKELFNKFHRYLKEDSLVFIGHSETLFGVSDKFKYVA SNIYKKI" gene 13757..14350 /gene="cheD" /locus_tag="cheD" /db_xref="1711756..1712349" CDS 13757..14350 /gene="cheD" /product="chemotaxis protein CheD" /translation="MIDFPAAANSNFKRITIYIGGYYASKEPAVIKTVLGSCISVCLF ENKLKFGGMNHFMLPEMREWENPAEDYNNTRYGVFAMEVLINEIIKLGGKKENLTAKI FGGGHVLSGMTSNILQVPDKNIQFAKKFLADEKIPIVSEDIGGSWPRKVFFFNTENRV LMKKLEGKTKEFSAEQEIKYSKNLQHKLEEKSDITLF" gene 14375..15508 /gene="" /locus_tag="" /db_xref="1712374..1713507" CDS 14375..15508 /gene="" /product="response regulator receiver modulated CheB methylesterase" /translation="MATKIKVLAIDDSALIRQLLTKIVNSDPALEMVGTAANPILAEN KVKNLKPDIITLDIEMPEMDGITYLKKLMLNNPIPVIMFSSLLDKHRELALDALNIGA FDYVIKPSANVRDGVEELATDLVEKIKNAYANRAKFYRKHGVTVPTEPAATTERSSIS LEAPKTAGFKVYQKNTADIILPLTPSRETPMDKIILIGSSTGGTEALIECLKNVTPSA PPIVIAQHMPEHFTTSFAKRLNSILKIDVFESEDGMSVGRGQAVLARGAKHTMIKVRG GKYYIEVRDGEPVTRHKPSVDVLFRSGAVYAKNKAIGIILTGMGDDGANGMKEMKDAG AYNIAQNEETCTVFGMPREAIARGGVDEVLPLDKILAAALKRV" gene 15602..16330 /gene="" /locus_tag="" /db_xref="1713601..1714329" CDS 15602..16330 /gene="" /product="hypothetical protein" /translation="LDFISKLISSHKQFNNISIIPTGSKRNRTDINYMEYLNIFLILD DTTNTSDTRKFKSSILELIKNNDLYSNKVNVTSSSLILEYESEKIVLIPSFKNLDNNV EGALVTDSNEKNEIFYPKLDNRNFDKKEHDCGANFINLIKLFKNLFLAFSAEIKYINE LTPAITEALIWNLPNEYFQFKDYADAILKALDYIYQRIASDDYMSLSEINDIKVLFSS RNNMDRKELLKALYKLKQFIHENI" gene 16440..18527 /gene="" /locus_tag="" /db_xref="1714439..1716526" CDS 16440..18527 /gene="" /product="glutamine synthetase" /translation="MKKIPEIFGSMVFNDNVMKDKLPKDIYKKLIKTIKNGERLNLEV ANVVAHAMKEWAIEKGATHFTHWFQPMTGITAEKHTSFITQTDDGSIRMEFTGKELVQ GEPDASSFPSGGLRATFEARGYTAWDPTSYAFIKDDTLCIPSAFCSYSGESLDKKTPL LRSMEVIEKEAKRILKLFGYDDVNRVFTTVGAEQEYFLIDRDLYLQRPDLRYCKRTLF GACPPKGQELEDHYFGAIKPRVLAFMKELDHELWKLGIVAKTEHNEAAPGQYELAPEF TVTNMATDQNQITMELMKVIAEKHNLACILHEKPFTGVNGSGKHNNWSIATDTGLNLL DPGDNPSKNKRFLLFLVAILKAVDEYQDLLRITTASASNDHRLGAAEAPPAIISIFLG DDITEILESLESSKKYKGKEKVEMEMGVNSLARLTKDTTDRNRTSPLAFTGNKFEFRM VGSSLSVSGPNIILNTIVAEALSQFADILEKSDNLEKDIDELIRETFKKHKRIVYNGN NYSNEWVKEAEKRGLFNLKTTPEALPHFISKKNIEVLTKHKVLTEAEIHSRYEISMEE YVKEINIEALTLIDMVHKQILPYSIEYVGELANTADKKRNLKLKFDVEKKLINKLNDL IKDLDSKLEKLEGYTVEAKKINDIAKSAKFSRDKIFACLEDMRVTIDELERTVSKKYW KLPTYGDMLYSLS" gene complement(18850..19614) /gene="" /locus_tag="" /db_xref="1716849..1717613" CDS complement(18850..19614) /gene="" /product="transcriptional regulator" /translation="MSDKKKFERLFELYTSLILDGFIDKKKFKYFNDSSKRTALRDID EIEKYLKIDLISEHNRYTIKKDDLKKLKKGFNFDDDNLKKNVDILFSVFMKKISSNLA LIPNSTIYKLLPQNVDNEYYDVIVISNNDINNISGDGENIEKLLSCVKDLNDINFDYY IQSSNINYKVKAIAYLIYYFQGIWYLVAYDHKHQKIKTYSISNISNIEIIQKLKFNNI KEKEEYEKEHKNRIDYREKLIKLIEKKKVYIGVIIN" gene complement(19626..20756) /gene="" /locus_tag="" /db_xref="1717625..1718755" CDS complement(19626..20756) /gene="" /product="hypothetical protein" /translation="MRIKKRLVAKKDDYYEYSSSYIRKYIAIIIVALFIILFTAIFIH VNYRVIPLKAYMRNDTPVLDANTLSITNNNGIYYTGDFTSIPKSIHINDDMVENLYLY LFHDNHIIFWKLYKYGLKRYFSYYAFNIFDGDSQSFIIKENEKDFLDFYDNFVRAQFR KNVGEFSIEIPNFYNTKINIKSSIENLINAEFSFKFTNFTASMVNWKYNRALYTAFYY GLPSGYLVVPGSENAITDTSSVMAVNTVGRNPSRYAHNIIAALVYTSYTTDPIPVFIY DSKPESQNSRIIKFLFKNKWYVYKNFESHEYKDVIDYYSKEEGFSFVFTVTGNYLYES FGGFSKIDMETTKGILDGYFTINNEQFNINGNAVKEFVHSVF" gene complement(20747..21877) /gene="" /locus_tag="" /db_xref="1718746..1719876" CDS complement(20747..21877) /gene="" /product="metal-dependent protein" /translation="MLERILYLVYYIPYFNFKIDEVYNLSKQLDENRIKEGVGGQAVI EGIMLRNKSHYVVAVRKPDKQIDFIKAAIPENKNKLSKMPFIRGVVNFVDMMRLGYKT LVFSANTAGIEEENNKKDSKPKSEKSENIAMTLSMLVSLAFAVGLFIALPYFITTLIG IDEKSNFVVFNLVRGCIKLSIFVLYLLVISFFKDIKRVFEYHGAEHMVVNAYEHGLDP DTGNIRDYTTIHPRCGTTFMFLVLTVSILLYMFTSYFVYTYIYASYTPPKIVGNLTVL AINIILLPIVSGISYEILKLGFKFYNFPLMRLAILPGLALQKITTRRPQDDEIEVALF ALSKLLDTSIEKRTEEEVQESIKASLENNDNIKSDTEEKLCV" gene 21933..22346 /gene="" /locus_tag="" /db_xref="1719932..1720345" CDS 21933..22346 /gene="" /product="hypothetical protein" /translation="MILIINFIILAFISCKSTTPQMKEVQEKSPVKKEEQIPKATTLK DRVGYYKSKSPYFTFNADLKENGYAYVVLKGWMVYRGYVKVGDPSSEATKFRLDIDNI TYVILEFKDLNNAKASVILKEVVQQVLPMSKVQNQ" gene complement(22398..23354) /gene="gspA" /locus_tag="gspA" /db_xref="1720397..1721353" CDS complement(22398..23354) /gene="gspA" /product="glycerol-3-phosphate dehydrogenase (D(P)(+))" /translation="MISVGIIGAGGWGLALANIFSEKHNVKVWVHSEDSYKLLSTSYR NDNYLENIELNKNIQFTMDIGDAVNDSEIVIIVTPSFAFAEACTNIEPYISNDQILVS ATKGLDRKTGKTMSEVARSIISGDLSILTLSGPSHAEEAAKGVPTAVVVGGEKGVSEY VRDTLTVPPKFRIYNSTDQKGVEIGGALKNIIAIAGGIVDGLKLGDNTKAALITRGLH EIVRFALSKGARIDTMYGLSGIGDLIVTCSSGLSRNNRLGRELAKGKKYQDVIAESHG QVAEGVYATTAAYEYAQKNIYICQSQKPYIIYFSIMRIYRIL" ORIGIN 1 agcgagttta tcgctagaaa taataagaaa ttattattta gaaccatttt caataagtat 61 tttttctatt ttagaatcat ttctatatct tgcataatct aatgctgtgt ttccattttt 121 atctttagca ttaagatcag ctccagcttc tatcaataac tcagctattt ctgtattata 181 atcaaaaatt acccacatta aaggtgtaat attttctaat tgtatatttc ttgaatcgtc 241 ttttatagat aatctagtat taatattagc cccagatttt attaataact cagctacttc 301 tgtatctaca ttaaatgtca aaggagtaaa atcttttaaa tataatccat ctgtcttgaa 361 tgatactttt gtatttacat cagatttttt ttctataagc atttttgata aatctgtttt 421 ctccctctgt atagcatgta ttaaagctgt aaatccggaa ttgtctttta tattaacatt 481 agcacctttt tctattaata tctctgctat ttcatattgc tcataaagaa tagataagat 541 taaaggtgta gcaccgcttt ctttctcttt tttattgaga tcagcacctt tttctattag 601 cagctttgca atttcatctt gcttataaat aatagataat atcaaaggtg tagcaccatc 661 cataatatct aaatttatat tgaccttttt attatttaaa aaatctaaaa cttcttcttt 721 attaccatta gctatatatg ctacaaattc tttttcatct ttactaagct ccggatacaa 781 agcattaaaa ctaaataaag tacacaatac tgccattaat acaatttttt tcatataaac 841 ctcttttaaa atattttaca aaaaagatat gttaattata ttattttgtc aagtatatac 901 ttcattaggg tatataattt cacgatgcta acatttaatt atttagttta ttttatgtat 961 attagaaata tttatatatt taacttttta atgatttaca aataaaaaat ctctatcagc 1021 tttaactaat agagatttta acactacata ttctttatta tttagcacct tttgatataa 1081 gtaactgctc tattttagga ttatttttat ctttcgcata atctaatgct gtttttccgc 1141 ttttatcttt agcattaaca tcagctccgg attctatcaa taacttaact atttcagaat 1201 tatcagtaaa aataaaccat attaaaggtg taatattttc taattttata ttttctccag 1261 catcttgaaa agagaattta atattaatgt ctgcactagc atttattaat gattgagcta 1321 cttctttatt ttcattaagt attaaaggag taacgttttt catatatact ccattttcat 1381 ttaatgatac ttttgtattt acatcagatt ttttttctat aagtattttt gatatttctg 1441 ttctattgta cattatagaa tatattaaag ctgtgaatcc taaattgtct ttgatattaa 1501 gatctgaacc tttttctata agcatttttg ctatttcatc ttgcttaaaa ataatagaaa 1561 atattaatgg tgtcgcacta ttttttattc tagcatttat attaattttt ttattatcta 1621 taaaatttga aacttcttca atatcaccag atgctatata cgataagaat agggcttcat 1681 tttcagagtt tgcaggatac agtgcattaa aactaaataa agtatacaac attgccatta 1741 atacaatttt tttcatataa acctcttttt ttaaaatatt ttaatatata tatattatta 1801 ttttctcaat tttatattta ttagttatta tttaggcaat acagaattta tatttaatta 1861 ctatattgcc tacactattg aattatataa caactaataa aaattattta tgaacttttt 1921 aaagtgataa ataagtagtt gtcagctagc tatctttcag caagtttatc tctataaata 1981 ataatagatt attaattagc attttttgct ataagcaact cttctatttt agtattgttt 2041 ttttcttttg cataatctag tgctgttttt ccgcttttat ctttagcatt gatatcagct 2101 ccagcttcta tcaataactg agctatttca gtattatcat tcaaaataaa ccacattaaa 2161 ggtgtagcat tttctaattt tagatcttgt ccaggatatt ttgcagtcaa ttttatatta 2221 atatcagcac cagcacttat taatgattgt gctacttctt tatcttcatt aagtattaaa 2281 ggagtaaaat ttttcatata tattccattt tcatttaatg aaagctttat atttacatca 2341 gctttttttt ctataagcat ttttgatact tctgttctat ttttcattat agaatgtatt 2401 aaagctgtaa atcctgactt atctttgata ttaagatttg cacctttttc tataagcatt 2461 tttgctattt catcttgctt ataaacaata gataatatta atggtgtcat accatcatct 2521 aatttggcat ttatattgat ttttttatca tctatataat ttgaaacttc ttcaatatta 2581 ccagatccta tatacaagaa gaactgtgct tctgtttctt cgtttgccgg atacaaagca 2641 ttaaaactaa ataaagtata caatactacc attaatacaa tttttttcat ataaacctct 2701 ttttaaaaat attttacaaa aaagatatat taattatatt attttgtcaa tatgaatatt 2761 ttattgtaaa tgataaaaac aattattata tattttaact ttataatatt gtgaatgatt 2821 atattgttaa tgtatttttt tagtgaatat atttaaataa ttaataaaaa taaatatctt 2881 ttatttacta taatattgtt gataaaataa aagctgataa ccaaaataat cagtcatcag 2941 ctaatttatt caatcatata gtaaaattat ttactattat gatttctttc tctttaaatc 3001 aatttgtctt tgaatctctt ttaagttttt aacatatatg gtattagttc ttatatctat 3061 tttacctgtt tttaccaatg tatttaaaac tttttgtaca tcaactactt ttacaccgca 3121 ccaatttgct atatcattta tagtggcatt tagttcctga ggttcataat aatgatctct 3181 aggtatgttt tgaagctctg ccaaaagtaa aagacagtca tatactctca agtcagtttc 3241 atttaattga agtattaaaa gtcttctttt agcatcgaat attcttttag caaaagtttt 3301 tgaaagtttc aaagccataa ctgtattatt agccaatatg ctttggaagt tttcttttct 3361 caactctaaa agcacagtag gttcatttgc tatagccgat gcacttcttg tagtatcttc 3421 taatatagcc atttcaccga aaaactcacc agcataaact atgtctaaca atttttcaac 3481 atcttttata acttttgtaa tttttactga accgctttga actaaataga atttatcacc 3541 tttttcatat tccagaaata taacatcatc agtattatat ttttttgtat gagaacttaa 3601 attattatcc atatttgttc cttaatttct ttttatatta cagtcttgaa atacttgcat 3661 tcgcttcctt tgaaaaatta tccataggag gcattgaaat aactttttga taatatgctt 3721 ttgctttagt tttatttccg ctgccctcac agcttttagc taaaaatagt atagcctctt 3781 taacattttg agatttagga tattttttta ttgctgacaa caatacagta gaagcattat 3841 catatttgtt tatattataa taacatttac ccatatagaa tatagaattc tcggcaacag 3901 cagtatcagg acttttaatt aaattattga atgcttttaa tgagttaaca taatcattat 3961 tattatataa ctcaacagcc ttattatatg cagggtcatt aattgctgct ttagcctgag 4021 tttttggagc tgaagcagga gcatttgaaa caggaggtgc tatatcacta tcatctgtaa 4081 tatctaattc ttctttacat tcttcaattt tttcttttac agtgttatag aatgctgaat 4141 cttcatctgc atactgtata tatcttttat aagcatatag agcatttcta tactttttat 4201 ttttaaagta aaattcccct attccgtata atccctctaa aggatcctgt ccttcttcgc 4261 ttatatcatt ttcaacaagt tctcttactc ttttattgat tcttctaagc tgatttgaaa 4321 acaccttaag catttttatg attataggtt tatttttttc aatcaaactt tcaaattctt 4381 cataagtaat tatgataaca acacaatctg ttaagcactg aaccgtatct tcttgcggat 4441 aagtaccaag tatacttttt accccaaaaa actcgcctat attaataagt tccctagttt 4501 cataacctgt ttcttctgat aaaaagatac tttgagcctg accttgtttc aagatataaa 4561 ctctgtctga ggtgtcgcct gtaaaatata ctatagaacc tgctttatat actcttgttt 4621 gcattaactt ttttcctcaa ctaataattt aattatatct aaagtttttt agaataaaaa 4681 aagattattt tattatttta ttctatcact tataatactt ttttcaagtt atttttttca 4741 ttttcttagc ttatttatca tatctacagt ttcaatatca atgtctttag accttgtatt 4801 taaatcatct attataattg taatctcttc atcttgcata ttctgaccga atttggcttt 4861 ggcagtaaga ttttcaattt ttattacgcc tataagcata ttattttgtg cataatcaaa 4921 catcttgttg tctatagaca gattatcatt attaggttcg tattttttta ctatttcata 4981 taaaatttct tttcttcttg atatatcatc tatagtttca aatttacctt ctataaaaac 5041 agaaaagaaa aactgtgtag gtatcatttt accatttaaa aattcagacg gtatatatga 5101 atatggtttt gaagcactaa aagaaacttt aggattattc tttagaattt catattttct 5161 gcccgccata gcaccatgaa aatatatttc attgttttta tagcaaaaac ttataggtac 5221 agcataaggt atatcatcag gcaaagccat aacaccaaat tctatactat taagcatact 5281 gtatatttct tctttatctt caaatataaa atcttttctt ctcatatacc aatgtataac 5341 ctttctaatt ataaattata actgtagact aaatcaataa attttattat aatatatata 5401 acggtttatt atattttttc tttataattt aattaatata aatacatttg gagttcgttt 5461 aatatgaaaa tagctgtttc tcaattagag ataataccat ctatgccttg cgataatact 5521 gttagaataa taagttttat aagcaaagct aaaaaagaaa atgctgatat agtgatattt 5581 ccggaattat gcgtttcagg ttatatgatt ggtgatatgt ttgaaagcga aggattcata 5641 aaagaatgcg aggaacttgg agaagaaata ataaaatctt caaatggaat atatgttatt 5701 tttggcaata ttgcatctga taaaaataaa aaaaattttg atggaagaat aagaaaatat 5761 aatgctatgt ttgtagctaa agatggtaaa ttaatacata ataataccac tgaataccct 5821 tttataataa aatccttact acctaattat aaagaatttg aagatccaag acattttttc 5881 agcttaaaag atttagcttt tgagaataat gctgatataa aagaatattt aaaacctttg 5941 gaaatagaat gcaatggtga aaagataaaa ttaggtctta ctatatgtga ggatgcatgg 6001 agcaaaaatt atacattttc tcctatggac attataaatt ctaacaaaga tgtagattta 6061 tttatcaata tatcaagttc accatatact ttagttaaag atgctaaaag acatagcatg 6121 tatggagaaa ttgcaagtaa acataatact cctcttatat acattaataa tgtaggaata 6181 caaaataatg gaaaaacagt gtatacattt gacggaagaa gttctgttta tgataataag 6241 ggtaatttat tattaacagg aaaaagatat gaagaagatt tgtatttcat tgatatagat 6301 gtgaaaaaca aagcatttgg aaaaactata gagataaaag aagaaaatga atataaattg 6361 atatatgaaa ctgttattta cggaataaga aaatttatga aatctatagg gataaataag 6421 gttgttatag gcgtatccgg aggtattgat tctgcattat catctgtaat gtatgtaaat 6481 gccattggaa aagataatgt tttactagtt aatatgccta gtaaattcaa ttctgataca 6541 actaaaaacc ttgcaaagac tttatctgat aatttaggat gtgcttatat ggtagttcct 6601 atacaggaat cagtagatta tactgtaaaa caattagaaa gctcccctat tataaaagac 6661 ggtaaagaag atcatctaaa attatcatct tttgttatag agaatataca ggcaagagat 6721 agatcatcaa gagtattatc tgctatagct gctagttttg gcggcgtatt tacatgcaat 6781 gccaataaaa cagaaactat ggttggatat tctactatgt atggagacgg agcaggattt 6841 tttgcttgtt tggctgattt atggaaatat cagatatacg gacttgctaa ttatgttaac 6901 aaagaagtat ttaaaaagga aattattcct gaaggcacta taaacattgt acctagtgcc 6961 gaactttcaa ctgctcaggc tgtagatgaa ggtaaaggcg atcctataaa atatgattat 7021 catgattatt tattcaaatt tttaatggaa tcttggaaca gagctatatt agaagatata 7081 ctagaacttt atatagaagg aaatttggaa gaaaaaatag gatgccaaaa aggaacatta 7141 aaaaaatatt tcaaaaatgg tgctgaattt gtagatgatt tagagagatg gtggaagcag 7201 tacatgggaa tgggtatatc taaaagaata caggctcctc caatacttgc agtaagcaga 7261 agaagttttg gattcggaaa tagagaatcg caaaatagaa tctattatac tgcaaaatac 7321 ttgaatttga aaaataaaat ttttgaaatt aattaaaaaa actttaatta aatatatttt 7381 tactgtaaaa ttatagtgta ataaaaattt tacttgcaaa aagcaataat aaatgttata 7441 tttataacgt gatatataat tttttagaat attgggaaat tataaaaagt ggcagcaact 7501 attatagaca ataatataag gcaggatatc cttgactatt ctgcaatatt agaaacaact 7561 gtgaaggata ttaactcttt tcttgaagaa gttggaagag tttatagctt tataggtgaa 7621 aaatttccta tgattgaaca ggaaatgaaa aatgaaaacg aaaaagctaa taagctgctt 7681 tcatatttta ccaataaaga aaaaggagaa aaaaacttct ctaatgattt agatgagaac 7741 caagaagatt tttttagatc ctttgataga atgcaaagtt ttatatctca agacaatgaa 7801 ctttctgatt ccttagtaga agacgttggc agaactagta atattatgga ttccatagaa 7861 caaattagga tgcttgctga ccaaattaaa gtttattcat taaatgccat tataatatct 7921 tctaaatatg gtgctggtgg taaggctttt ggagaaatat ccaaaaacat aatcaaaatg 7981 tctgaaacat caaatgaaca ggcagatcaa atgaatagaa tcggtaagga gttatttgta 8041 aggtttgagt catttaaaac tgaaatatta aaaacaaatg aattgcaaag acagaatttt 8101 acaatcatga gagaacagct tgataaagag cataataaca tggttaattc ctttgcagta 8161 ttttctaata taatatcaga tataatatca agagttgata atacttatga ttttatattt 8221 gaagtaatga tggttcttcc tcgtgaagat atagtaagac agcagactga gcatataata 8281 gaatctatga attccatagt ttatgaaaat agaaatttca tagaatatta tggaaaagaa 8341 gtagaaacta tggatgctgc tgatcttgaa aaagaagaaa atcaaagttt agaacataaa 8401 cttcttgact tgcttacttt tgatgatgta gttttaactc taataataga aaactttaaa 8461 tcaatacatg aggaaattga tcttacaaac tcagatattt ataaaagttt aaaaggttta 8521 aaagatgcat tgacagatat tacattagat agaactacta tagttgaata tatgattgga 8581 ggcgaaagcg gtaaatcaga gtttcctttc acagtttcag agtctttgtt caatgaatat 8641 atgggattca ttaaacttta tttagaaaac tttaaattat ttttaactaa taaatacaga 8701 atatctgaca gcaatatagc tataatagac tcaatagaag aattggaaag catgttctta 8761 gaaacaaaaa acattgctaa aacttttaac tctattaact ttttagctaa aatagaactt 8821 gaaaagaata gcgatatatt taataattcg cagactttct ctatagaaag tgttgaatca 8881 atagctacta acattacaga aacagtagat ggatgtttag agcagttcca taatattaaa 8941 tctgctattt tcagttcaat taataaattt aaatctaata tcaatcagca gtcgagcgag 9001 cattctttta tagaatctat gacagacagc gtaagcaaac gtttagatga atcaaaatat 9061 attattaata ataacataaa aagattagat agttatgctg atgaattatt tggacttata 9121 gacaaaaccc taatagattt aagttcatta agtacattgc ttacaaagat taatgaaata 9181 atagaaatct ttaatagcat gagaaatgtt ataagagata agaaaaatga atattataat 9241 ttattaggta tagaaaattg gaaaatagaa agtgataaat atttggatat agttaattct 9301 tatacgataa agaaagaaag agctattgct aatagtattt tatctggaga agatgcgccg 9361 aatgtcgata taagtataga tgtaggtgct gatagcggcg attttactat gttttaataa 9421 aagtaatgga ggtatttatt tatgtcagtt atagagataa atgataatct taatataaga 9481 actatgagta aatattttaa gaatgtcata aaaagtgcta attataacga agatatgact 9541 gtaaaattta attgtgaggg tgatgcccat gtggatttag caggacttca aatactgtat 9601 gctatgaaaa aagaacttgc taaaaatcaa aaaaacctta tagtagaagg tatggataat 9661 ttgtttgtag aatatttaaa aataattaat gataaaaata attaatgatt aagaggttaa 9721 atctatggct aaaacaatac taattgtaga cgattctaat acagctagag catctgttga 9781 atatacttta aagaaaggca gctatactgt agtgtctgca gatgatggta ctacaggatt 9841 agaggttctt ggtaaaacac caaatgttga tatgataata acagacctta acatgccaaa 9901 aatggatggt atagaattca ttaagcatgt aagaaaagta gatcaacata aatatacccc 9961 tattctaatg cttacaacag aatctcaaga tgagaaaaaa atggagggta aagctgcagg 10021 tgctagtggt tggctagtaa agccatttaa cccaactcag cttttagatg tagtaaaacg 10081 ttttttaaat tgatttctaa ccatcttatt ttatataata aggattttat aaaggtagag 10141 gtgctatatg tttgatagtg atgaatttat ttcgatattc ctaagtgaag ccaatgaaat 10201 tgtagaaggt cttgaaaacg acctagtttt gttggaagat aataaaagtg atgaagatct 10261 tttaaataaa atatttagaa gtgctcacac tcttaaatct tcagcaggta cagttggctt 10321 tacaactatg agtgagttaa accacgttgc tgaaaactta ttagaaaaag ttagaagcgg 10381 caagttggat gttactcctc aaatgattac agtattgtta gagttcctgg atactgtaaa 10441 attaatgttg caaaatattg tagacggtaa aagtgaaact gaaggtgtta ccaatataga 10501 ttcactaaaa gctaaaataa aagctatagc tgacggtaat gatgtaagta ctgctgcagc 10561 tgcaccaaaa gcatctcctg aacctaaaaa agaagagcct aagaaagaag aggctaaagc 10621 tacagaaact aaacctgaag aaaaaaaaga agatacgaaa gctgatgaat catctgctac 10681 ttcaggcgga gaaaattcat tccatatcga aatgggattt aaagctacta tttttgataa 10741 tggtatagac cctcttatgt tcttaaatga ccttagagct ataggtacta ttagtaactt 10801 aaaaatagag tgtaatagct tacctactat cttaaatctt gaagatcctt atgtttgtta 10861 tactcagttc tctttggatt ttgaaactaa tgctcctgaa gaacaagttc agaatatttt 10921 cttatttgta atagatgata atgatattaa tattataaat actaaagctg aaataaaaga 10981 tgatgatgaa gcaaataaag cagttgaaac taaagaagaa cagcctgcaa aagaagaggc 11041 taaagaagat actgctgcta aacctgaaga aaaacctgca gaaacagctg cagctgctag 11101 taaacctgca gcagctccta aaactggtac aaaagttcag gctccttcaa cagtaagggt 11161 tgatacaaga aaattagaca gcttaatgaa cttaatcgga gagcttgtta tagcacagtc 11221 aagaataatg cagcttactc aaagtttaga tatagataat ggacttaaag aggctgtaag 11281 ttcaatggat agaacttcaa gacaaataca agaagaagtt atgaatatcc gaatgatgcc 11341 tatcggtcct atattcactc aattccatag atatgttagg gacttaaatt tagaattaaa 11401 caaagaagtt aaactagttc ttaaaggtga aactacagaa atagataaaa atatgttaga 11461 gcagttatct gaccctctta aacatattat aagaaactct atggaccatg gtatagagaa 11521 aacaaaagaa gaaagaatag ctagaggtaa gcctgaatat ggtacaataa caatgtctgc 11581 agctcaccaa gaaggacatg ttgttataga agtatcagat gatggtaatg gattgaataa 11641 agaaaaaatc tttaataaag ctgttgaaaa aggacttctt tcaaaagatg gtaaatattc 11701 tgatatagaa atatacagaa ctattttctc tcctggtctt tctactgctg aaaaaataac 11761 agacatatca ggaagaggtg ttggtatgga tgttgttaga gctaatgtag aaaaaatgaa 11821 aggtaaaata gaaattaaat ctgctgaagg tcaaggtagt acattcataa taaaattacc 11881 tttaacattg gctattattg aaggtattac ttttgcttta ggtaaacaaa tatacataat 11941 gcctttgatt tcaattatag aacaaataaa agtaaaaaac gaacaggtaa aaccttttga 12001 aggcaaaggg gaaatgataa aaatcagaga tgagtatttg cctttaatta gattacacaa 12061 agtatttgaa atagatacac aagttgaaaa tatagatgat ggtatagttg tagttgttga 12121 agctggatat agaaaatgtg ctatatttgt tgatgagctt ttggatcagc agcaagtagt 12181 tattaaatct ttagattcag cattcagtaa acatgcagga atagccggag gtactatact 12241 tggagacgga agaatagccc ttattataga tatacaggga ctagtaaata tgtctttaca 12301 aggaaaaatt aataacggcg ttaaataaag gattgtaata tgttagataa tcaaaaaata 12361 aatgcagcta atatacctca ggttggaggt acatctttag aacatgatga aaacatttct 12421 attgaaccta gtcagcaatt tttagtgttt aaaattgata atgaagaata tgctcttgat 12481 gtattgagta ttgaaggtat tgtaggcgta actaatataa ctcctgttcc tggaagtcct 12541 aaatttatga gaggacttat gaatttaaga ggtaatattc ttcatatagt tgatataaga 12601 ataagatttg gtttggatag aagagatgat cattctattg aagatgatgt tattatagtt 12661 atatccacta ctaatagaaa atttggtata ttagcagata tggtaagtga tgttattaca 12721 gtttatgaaa gccagatgac agaaactcct attgataata tgagaggact tcaaatttct 12781 aatgttatta gattggaaaa taagatcatt atggttcttc ctatagaaga aatcataaaa 12841 tctaatgaaa caaccaatca aacagtataa tatcattgag gtataaaaat ggaagatatg 12901 aatgagcata tgccggctct gagtgatgct gagtttaatg aattagttaa aattatttat 12961 gataaaacta gaatacaaat gactagtcat aaaagggctc tagtaacctc tagattgagt 13021 aagagattaa gagccttaaa aatggactct tttagggagt atatagactt tgtcaagaat 13081 gctaaagatg aagaattaac taatttcgtt aatgctgtta ctacaaataa aactgacttt 13141 ttcagagaaa ataagcattt tgagtatatg aaaagtacat ttcttccaga ttgggaaaag 13201 aattttaaag ctggcaaagt gaaaaatctg agaatatggt ctgcagcatg ctcaactgga 13261 gaagaaccct acactattca aatgactttg catgaatatt ttggtgctaa ttatgataaa 13321 tatgatataa aagttttagc tagcgatata gatacaaatg tattggcaca tggtagagct 13381 ggtatttata aagaagaatc tgttgaacca atacaagaaa atatattaag aaaatatttt 13441 ttgaaaggta caggtgataa agagggatta tataaagtta aagacatttt gaaaaagaat 13501 ctgtttttta gacaattaaa tttcaaagat gaagattttg atattcatac tcaatttgat 13561 ttgatatttt gccggaatgt tattatttat tttgataaag aattccaaaa ggaattattt 13621 aataaatttc atagatattt gaaagaagac agtttagtat ttataggaca ttcagaaaca 13681 ttatttgggg tgtctgataa atttaaatat gtggcaagca atatttataa aaagatttaa 13741 ctaggggtgt ataataatga ttgattttcc agcagcagcc aatagcaatt ttaagagaat 13801 cacaatatat ataggtggtt attatgcttc aaaagaacct gctgtaataa aaacagttct 13861 aggcagttgt atatctgtat gcctgtttga gaataaatta aaattcggag gtatgaatca 13921 ctttatgctt cctgaaatga gagaatggga aaatccggct gaagattata ataatactag 13981 atatggtgtt tttgcaatgg aggttcttat aaacgaaatt attaaattag gcggtaaaaa 14041 agaaaacctt acagctaaaa tattcggagg cggacatgta ctttcaggta tgactagcaa 14101 tattcttcaa gtacctgata agaacataca atttgctaag aaatttttag cagatgaaaa 14161 aatacctata gtaagtgaag atataggtgg ttcttggcct agaaaagtat tctttttcaa 14221 tactgaaaat agagtactta tgaagaaact agaaggtaaa actaaagaat tctcagctga 14281 acaggaaatt aaatattcta aaaatttaca gcataaactt gaagaaaaat cagacattac 14341 attgttttaa tatattaata attaaggatt ttatatggct acaaaaatta aagtattagc 14401 tattgatgat agcgcattaa taagacagtt gcttactaaa attgtaaact cagaccctgc 14461 attagaaatg gtgggaactg ctgcaaatcc aattttagct gaaaataagg tcaaaaatct 14521 taaacctgac attattactt tagatattga aatgccagaa atggatggta ttacatatct 14581 taaaaagctt atgcttaaca accctattcc cgtaataatg tttagttctc ttttagataa 14641 acatagagaa ttagctttag atgctttaaa tattggagct tttgattatg taattaaacc 14701 ttctgcaaat gttagagacg gtgtagaaga attagctaca gacttagttg aaaaaattaa 14761 aaatgcttat gcaaacagag ctaagtttta tagaaaacat ggtgttacgg ttccaacaga 14821 acctgctgct actacagaaa gaagttctat tagtttagaa gcaccaaaaa cagccggatt 14881 caaagtttat caaaaaaata ctgcagatat catacttcct cttacacctt caagagaaac 14941 tcctatggat aagataattc ttataggttc ttcaacaggt ggtacagagg ctttaataga 15001 atgtcttaaa aatgttactc cttctgctcc tcctatagtt attgctcagc atatgcctga 15061 acattttact acttcatttg ctaagagatt aaatagtatt cttaaaatag atgtatttga 15121 atctgaagat ggtatgagtg ttggaagagg acaagctgta ttagcaagag gtgctaagca 15181 tactatgatt aaagttagag gcggtaaata ttacattgaa gtaagagatg gagagcctgt 15241 tacaagacac aaaccttctg tagatgtact tttcagaagc ggtgctgttt atgctaaaaa 15301 caaagctatc ggaataatac ttacaggtat gggtgatgat ggtgctaatg gtatgaaaga 15361 aatgaaagat gccggtgctt acaatatagc tcaaaatgaa gaaacttgta cagttttcgg 15421 aatgcctaga gaagcaattg caagaggcgg tgttgatgaa gttttaccat tagataaaat 15481 acttgctgcc gctctaaaaa gagtgtaaat gtaaaatgga taataatata gatttatatg 15541 aatatataaa tagatgggta agcggattta aagcttaccc atattataaa atagaaaaaa 15601 attggatttc atatccaaat taatatcttc tcataaacag tttaataata tttctattat 15661 tcctactggt tcaaaaagaa atagaacaga tataaactat atggaatatt taaatatatt 15721 tttaatattg gatgatacaa ctaatacatc tgatactaga aaatttaaat cttctatttt 15781 agaattaatt aaaaataatg atttatattc aaataaggtt aatgttacat cgtcatcttt 15841 aattttagaa tatgaaagtg aaaaaattgt attaatacct tcattcaaga atttagataa 15901 taatgttgaa ggtgctttgg ttacagatag taatgaaaaa aatgaaattt tttatcctaa 15961 attggataat agaaattttg ataaaaaaga acatgattgt ggtgctaatt ttatcaattt 16021 aataaaatta ttcaaaaatt tattcttggc tttttctgct gaaattaaat atattaatga 16081 attaactcct gctataacag aagcacttat atggaattta ccaaatgaat attttcaatt 16141 caaagattat gctgatgcta tattaaaagc tcttgactat atttatcaaa gaatagctag 16201 tgatgattat atgtctcttt ctgaaattaa tgatataaaa gtgctatttt catctagaaa 16261 taatatggat aggaaagaat tattaaaagc attgtacaaa ttaaaacaat ttatacatga 16321 aaatatataa aattctaatt ttttctcata acttctaata gtaatattga attaatttaa 16381 actaatgata taatagttct aattttttat aataaatttc ttagggagaa atatataaaa 16441 tgaaaaaaat accagaaatt tttggtagta tggtttttaa tgataatgta atgaaggata 16501 aacttcctaa agacatttat aaaaaactca taaaaaccat aaaaaatgga gagcgtttaa 16561 atttagaagt tgccaatgta gtagctcatg ctatgaaaga atgggctata gaaaaaggtg 16621 ctactcattt tacacattgg tttcagccta tgacaggaat aacagctgaa aaacatacaa 16681 gctttattac tcaaaccgat gacggttcca ttcgtatgga gttcacaggt aaagaattag 16741 ttcagggtga gcctgatgct tctagttttc cttcaggagg acttagagct acatttgaag 16801 ctagaggata tactgcttgg gatcctacat cttatgcttt cataaaagat gatacattat 16861 gcatacctag tgcattttgt tcatatagcg gagaatcttt agacaagaag actcccctac 16921 ttcgttctat ggaagttata gaaaaagaag caaaaagaat attgaaatta ttcggctatg 16981 atgatgtgaa tagagtattt actactgtag gtgctgaaca agaatatttc ttaatagaca 17041 gagatctata tttacaaaga cctgatttaa gatattgtaa aagaacatta tttggtgctt 17101 gcccacctaa aggtcaggaa ttagaggatc attatttcgg agctattaaa cctagagttc 17161 ttgcttttat gaaagaactt gatcatgaac tttggaagct tggaatagtt gctaaaacag 17221 agcataatga agctgctcct ggacaatatg aattggctcc tgaatttaca gttacaaata 17281 tggctaccga tcagaaccaa attactatgg agcttatgaa agtaatagcc gaaaaacata 17341 atttggcatg catacttcat gaaaaacctt ttacaggcgt aaatggaagc ggtaaacata 17401 ataactggtc tattgctaca gatacaggat taaacttgct agatccggga gataatcctt 17461 ctaaaaataa aagattctta ttatttttag ttgctatact aaaagcagtt gatgaatatc 17521 aggatctttt aagaataact actgctagtg ctagtaatga tcatagactt ggtgctgctg 17581 aggctcctcc tgctattata tctatattcc ttggagatga tattacagag atacttgaat 17641 ctttggaaag ctctaaaaaa tataaaggaa aagaaaaagt tgaaatggaa atgggagtta 17701 attctttagc aagattaact aaagatacaa ctgacagaaa cagaacttct cctttggcat 17761 ttactggaaa taaatttgaa tttagaatgg ttggatcaag tctttctgta tcaggcccta 17821 acatcatttt aaatactata gtagctgaag cattatcaca atttgctgat attttggaaa 17881 aatctgataa cttagaaaaa gatattgatg agttaataag agaaactttt aaaaaacata 17941 aaagaatagt atataatggt aataactatt ctaatgaatg ggttaaagaa gcagaaaaga 18001 gaggtttatt taatttaaaa actactcctg aagcattacc tcatttcata tctaaaaaga 18061 atattgaagt attaactaaa cataaagttt taacagaagc agaaatacat tcaagatatg 18121 aaataagtat ggaagaatat gttaaagaaa ttaatataga agctttaaca ttaatagata 18181 tggtacataa acaaatactt ccatactcaa tagaatatgt tggtgagctt gcaaatacag 18241 ccgataaaaa aagaaattta aaattgaaat ttgatgttga aaaaaagtta attaataaac 18301 tcaatgattt aataaaagac cttgattcta aattagaaaa attagaagga tatactgtag 18361 aggctaagaa aattaatgat atagctaaat cagcaaaatt ctcaagagat aaaatatttg 18421 cttgtttaga agatatgaga gttacaatag atgagttaga aagaacagta tcaaaaaaat 18481 attggaaact tccaacttac ggtgatatgc tatacagttt atcataaagt aaaatataac 18541 aagggtgata gattatataa tctatcacct tttcttttta taacttattt tatttatttt 18601 cttcattcat aatagataaa gaataattta aatgctctat aagttcatca ttaaattttt 18661 taggtgatat tatcttaaaa gaaccaagcc aaggacttac aaatattcta aactctgtaa 18721 aagatgaaaa atcaaaatta actattatag agccatcatc taatttcttt ttgattttct 18781 gattgaatcc ataatctcta tttttaaaat aatgagcaac atttgaatta aaatgaatag 18841 tagtttttat taatttatta tcactccaat atatactttt ttcttctcta ttagttttat 18901 taatttttct ctataatcaa tcctattttt atgttctttc tcatattctt ctttttcttt 18961 aatattatta aattttaatt tctgtattat ttctatatta gatatattgc ttatagaata 19021 agtttttatt ttttgatgtt tatgatcata agcaaccaaa taccatatac cttgaaaata 19081 ataaataaga tacgctatag ctttaacttt ataattaata ttactgcttt gaatataata 19141 atcaaaattt atatcattca aatcttttac acatgaaagt aatttttcta tattttcacc 19201 atcaccggat atattattta tatcattatt tgaaatcaca ataacatcat aatattcatt 19261 atccacattt tgaggtaata atttatatat tgtcgaatta gggataagag ctaaatttga 19321 acttattttt ttcataaata cagaaaataa tatatctaca ttttttttaa gattatcatc 19381 atcaaaattg aacccctttt tcaatttttt taaatcatct ttttttattg tatacctatt 19441 atgttctgaa attaaatcta tctttaaata tttttctatt tcatctatat cacgcaaagc 19501 tgttcttttt gatgaatcat taaaatactt aaatttcttt ttatctataa atccatccaa 19561 tattaaagaa gtatacaact caaataatct ctcaaatttc tttttatctg acatactata 19621 tccttttaaa atacgctatg tacaaattct ttaacagcat taccattaat attaaactgt 19681 tcattattta tagtaaaata tccatctaat atgccttttg tagtttccat atctatttta 19741 ctaaatcctc caaaagactc atatagataa tttcctgtaa ctgtaaatac aaaactaaaa 19801 ccttcttctt tagaataata atctataaca tctttatatt catgcgattc aaagttttta 19861 tatacatacc atttattttt aaacaagaat ttaataattc ttgaattttg tgattcaggc 19921 ttagagtcat aaataaatac gggaatagga tctgtggtat aagaagtata aactaatgcc 19981 gctattatat tatgagcata tcttgaagga tttcttccta cagtattaac agccataact 20041 gaacttgtgt cggttatagc attttcactt ccaggaacaa ctaaatatcc gcttggaagc 20101 ccataataaa aagcagtata taatgcccta ttatatttcc aatttaccat agaagctgta 20161 aaattagtaa atttaaatga aaactctgca ttaattaaat tctctataga agattttata 20221 tttattttag tattataaaa gtttggaatc tctatactaa attcaccaac attttttcta 20281 aattgagccc ttacaaaatt atcataaaaa tctaaaaaat ctttttcatt ttcttttatg 20341 ataaaagatt gagaatcacc atcaaatata ttgaaagcat aataagagaa ataccttttt 20401 aatccatatt tataaagttt ccaaaatatt atatgattat catgaaacaa gtataaatat 20461 aaattttcta ccatatcatc atttatatga atagattttg gaatactagt aaaatctcca 20521 gtgtagtaaa taccattatt attagtaata gaaagagtat tagcatcaag tacaggagta 20581 tcattcctca tatatgcttt taaaggtatt actctataat taacatgtat aaatatagct 20641 gtaaataata taataaataa agctacgatt attatggcga tatattttct tatataactc 20701 gaagaatatt cataataatc atcttttttt gctacaagac gtttttttat acgcataatt 20761 tctcttctgt atcgcttttt atattatcat tattttctaa actagctttt atactctctt 20821 gcacttcttc ttctgttctt ttttctatag aagtatccaa aagcttgctt aatgcaaata 20881 atgccacttc tatttcgtca tcttgcggtc ttctagtagt tattttttga agagccaaac 20941 ccggaagtat agcaagtctc ataagaggga aattataaaa tttaaatcct aatttcaata 21001 tttcataaga tataccagaa actataggaa gtaaaattat attaatagcc aatacggtta 21061 aatttccaac tattttagga ggagtatatg acgcatatat atatgtatat acaaaataac 21121 ttgtaaacat ataaagcaat atagaaactg ttaatactaa aaacataaat gtagtaccgc 21181 atctagggtg tatagttgta taatctctaa tatttcctgt atcaggatct agtccatgtt 21241 cataggcatt aacaaccata tgttcagcac catgatattc aaatactctt tttatatctt 21301 taaaaaatga tattacaaga agatataaaa caaatataga taattttata catcctctta 21361 ctaaattaaa tacaacaaaa ttacttttct catctatgcc aataagtgta gttataaaat 21421 aaggtaaagc tataaaaagt cccacagcaa atgccaaaga cactaacata cttaaagtca 21481 tagcaatatt ttcacttttt tcggatttag gcttactatc ttttttattg ttttcttcct 21541 caatacctgc agtattagca gaaaaaacca aagttttgta tcctaatctc atcatatcta 21601 caaaatttac aacacctctt ataaaaggca ttttactcaa tttgttttta ttttcaggaa 21661 tagccgcttt aataaaatct atttgcttat caggctttct aacagcaaca acataatgac 21721 ttttatttct aagcattatc ccttctataa cagcctgacc gcctactcct tctttgattc 21781 tattttcatc taattgttta ctcaaattat acacctcatc tattttaaag ttaaagtaag 21841 gtatataata tactaaatac aatattcttt caagcataaa aaaaacttga atttgtaaaa 21901 aaatttatat attatatgat atgaagccct taatgatatt aattattaat tttattattc 21961 ttgcttttat ttcatgcaaa agcacaactc ctcaaatgaa agaagtacaa gaaaaatcac 22021 cagtaaaaaa agaagagcaa ataccaaaag caactacttt aaaagataga gtgggatatt 22081 ataaaagtaa aagtccatat tttacattta acgccgattt aaaagaaaat ggatatgcat 22141 atgtagtatt aaagggctgg atggtttata ggggctatgt aaaagttggc gatccttcat 22201 ctgaagctac aaagtttaga ctagatattg acaatattac ttatgttata ttagaattta 22261 aagatttaaa caatgcaaaa gcgtcagtta tattaaaaga agtagtacag caagtgctgc 22321 caatgagtaa agtgcaaaat caataaatat atattaaaag aatccttcac tcttagcatc 22381 tttgctcata agttcagtta aagtatcctg tatattcgca ttattgaaaa gtatattata 22441 tatggcttct gtgattggca tatatatata tttttttgag catattcata agcagcagta 22501 gtagcatata ctccttcagc aacctgacca tgactttcag ctattacatc ttgatatttt 22561 ttacctttag caagttctct gcctagtcta ttgtttctac ttaatccgct tgaacatgtt 22621 actattaaat cacctattcc agaaagtcca tacatagtat ctattctagc acctttactt 22681 aaagcaaatc tcactatctc atgcaatcct cttgttataa gagcagcttt tgtattatca 22741 ccaagtttaa ggccatcaac tataccacct gcaatggcta taatattttt taaagctccg 22801 cctatttcaa cacctttttg atcagtagag ttatatattc taaatttagg aggtactgtc 22861 aatgtatctc ttacatattc agaaacacct ttctcccctc ctacaacaac tgcagtaggt 22921 actccttttg cagcctcttc tgcatgagaa ggtcctgaaa gtgttaatat agataaatca 22981 cctgatatta tgctccttgc aacctcgctc atagtttttc ctgtttttct atcaagtcct 23041 ttagttgcag atactaatat ttgatcatta cttatataag gctctatatt tgtacaagct 23101 tcagcaaaag caaatgatgg agttactatt ataacaattt cactgtcatt tactgcatcg 23161 cctatatcca tagtaaattg tatgttttta tttaattcta tgttttccaa ataattatca 23221 tttctatatg aagtgcttaa taatttataa ctatcttcac tatgtaccca tactttaaca 23281 ttatgctttt ctgaaaatat atttgcaagg gcaagtcccc atccgccagc acctatgatt 23341 ccaacactta tcat //