LOCUS NC_016584:16 18693 bp DNA linear BCT 06-SEP-2013 DEFINITION Desulfosporosinus orientis DSM 765 chromosome, complete genome. ACCESSION NC_016584 SOURCE Desulfosporosinus orientis DSM 765 chromosome, complete genome. COMMENT locus start: 3645245; locus end: 3663937 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.598476; n0_4mer:D = 27.559582; n0_4mer:PS = 46.741381 FEATURES Location/Qualifiers source 1..18693 /organism="Desulfosporosinus orientis DSM 765 chromosome, complete genome." gene complement(1..765) /gene="" /locus_tag="" /db_xref="3645245..3646009" CDS complement(1..765) /gene="" /product="hypothetical protein" /translation="MLKVLVAEICSEITVVNAFGNLNSENPKLLGQGTFPTTVQEGDI SLGVKQAMADLEKEIGPWGSITDMPFYAVYPIQFEGLNSKGIASNYFNEGILPASEAM MIAVQLIYEEVGDVLVLKLEEESITVYSVTSNSLPLVESHSTNRNKHIKTKPETSEEI ALRAELTAEALKAAVKSYCELSIHFRWIVGTGSSLTELPNGLQILTESVKGIESQGET AILLDRDCLMTSLGALTANYRQGAWQLLRESMGVEN" gene 959..1630 /gene="" /locus_tag="" /db_xref="3646203..3646874" CDS 959..1630 /gene="" /product="cell wall-associated hydrolase" /translation="VKKSIILLVLVVLAFFSSASVTQAAVFKVGSAGSDIRVLQSELQ TLNYDVGPVDGIFGSKTRAAVEAFQRDHNLMVDGIVGPQTQKALDDANIQPSEKTQRS ETTEQIINTAKSFLGVPYKWGGASPDGFDCSGFTSYVFATQNISLARVSLDQYRMGTS VSFSDLAPGDLVFFTFSSSKLVSHVGIYIGDNQFISATNSKGIAIYSFSPYWSNAYVG ARRVY" gene complement(1786..2136) /gene="" /locus_tag="" /db_xref="3647030..3647380" CDS complement(1786..2136) /gene="" /product="hypothetical protein" /translation="MNRKKELKEQYRQLKPEMGVFMIRSNRNNKCLIEGTLRLNATIN RVKFQLDFGSYPNRELQKEWKEYGEANFTFRILENLEYEKDETKTDYSDELELLQMDW EERMAKQDFEFYMK" gene complement(2139..2618) /gene="" /locus_tag="" /db_xref="3647383..3647862" CDS complement(2139..2618) /gene="" /product="hypothetical protein" /translation="MKIPTTLKHKPVIVSENYENVDGRYAYNSDAKGLSLGLAQWNDR GKVDVSAKVWRYTGEKWSRQSEELPLHRVLDLAILISRTKLHFRDAYRYQELYDTENP VIDRVGLQGDAMTVAVCTDNEKINEDIKLFNQVLSVDDELIGERLRTLARILREMGY" gene complement(2980..4767) /gene="" /locus_tag="" /db_xref="3648224..3650011" CDS complement(2980..4767) /gene="" /product="ABC transporter ATPase" /translation="MDITKISEFLSWPWYFCVCAKVSRLFGIHDTILSGLGGVFILLV ECSNLKKYFADRLIIQLENFKVYSEDRIGIVGANGVGKTTLLKILSKGLEPDEGQVKL YGKCAYISQLDPPEQKQTSAELAAQFGISSTWNETMSGGETTRFKLAQSLSQDCPLIF ADEPTSNLDLEGIELLERRLAEHRSGLILISHDRRFLNQLCNKILEIEEGELKVYPGN YSDYCVQKQEERERRQFEYQQYIKEKKRLLGAVEETKQKVKNVRKTPKRMGNSEARLH KMGDQKAKASLDRAIKSTETRIEHLEVKEKPAEQQRIKLDVTDSGMLYSKIIIEGNDI CKTFGKEAIFRDAEFKIENGAKVALIGPNGCGKSTLLKMILAKDDSLKVAQGAKIGYF SQDMTILKDKLSIIENVMEESIYQESFVRTLLARLLLKGDAVYKQVGLLSGGERVKVS FAKILLQDINLLILDEPTNYLDINSLEVIEEALRGYNRTLLFVSHDRSLIGSVADHIM TIENQGIQMFQGSYADYLAQKDRSSDDGREDLEKQVLILQHRLTEVVGRLSIPRKKDD MQALDKEYHELLAKLKPLREKLKGLTGLS" gene complement(4970..5512) /gene="" /locus_tag="" /db_xref="3650214..3650756" CDS complement(4970..5512) /gene="" /product="hypothetical protein" /translation="VGNKQVALIRGINVGRAKRVAMADLRSLVVGLGNGDVRTILNSG NVVFTAIEAHAVTSAQRIELGLLEKLGVSAKVIVVSEQELVQVVSENPLDYAAKDPSR FLVAFLEKPEDRDKLKDLARKDWAPEALAMGERVAYLWCPNGILKSQLPAEVGRILGD TVTTRNWATVMKLYGLIGCQ" gene complement(5566..6813) /gene="" /locus_tag="" /db_xref="3650810..3652057" CDS complement(5566..6813) /gene="" /product="gamma-glutamyl phosphate reductase" /translation="MFEAKLIEIGQRAKQAARLLAYASTESKNNALLAMAEALLKNQE EILEANQRDVQAAEEKGLKKSLVNRLRLTAASIAQISQSLKEVVALRDPVGEGEIWTR PNGLRIQQVHVPLGVVAMIYEARPNVTVDAAALCLKSGNVVILRGGSEALESNKVLAR VIAEAAEASGLPGGCIQLITETSREWVQKLIRMNEFLDVIIPRGGAGLIQAVVQNSTV PVIETGTGMCHAFVDRDADYEKAVPIVVNAKTQNPGVCNALETLLVDEGIAAEFLPLI GEELKKLNVQLKGCPRTCDILTYSLPATEDDWKYEHLDLILGVKVVPDLDGALNHIYQ YSTKHSETIVTENYSRAQRFLREIDAAAVYVNASTRFTDGGRFGFGAEIGISTQKLHA RGPMGLKELTTIKYMVYGDGQIV" gene complement(6850..7971) /gene="" /locus_tag="" /db_xref="3652094..3653215" CDS complement(6850..7971) /gene="" /product="glutamate 5-kinase" /translation="VTLNGVRRIVLKIGSSSLNHPQGGLDEAAIAQVVSAIADLKKHG VECIIVTSGAVAAGMGRLKLHNRPRDLPGKQAVSAVGQGVLIEMYTRNFEQHGIVGAQ VLLSRIDLAQASHYRNAQNTLEKLLRLHVVPIINENDTVAVDELCFGDNDTLSALVAG LVGVDLLVILTDVDGLYTANPKKDQSAQLIKEVAEVSAVECMASGAGSMLGTGGMVTK LRAARIATHFGIGTLLLNFTRLKELDDLTKGEAPEGTYFKPVKHRLAGRKRWIAYAGL SEGCIHVDDGAAKALLEEGKSLLAKGITGVSGTWERKEIVRILNSRGEEIAKGVVELN HDEVLQVKGMHSGKLHELIENFEGEEVVHRDNMTVMVDM" gene complement(7968..8777) /gene="" /locus_tag="" /db_xref="3653212..3654021" CDS complement(7968..8777) /gene="" /product="pyrroline-5-carboxylate reductase" /translation="MSYSIGFIGGGNIAEAMISGLKKTNKELEIRVTNLSNRGRLQGL VDRYDVTAASLQDLVENSQVVIIAVKPKDVQGVLKDLTAFSLQNKLVISVAAGVPLRV FAKYLPGVAVIRAMPNTSMAVLHSMTGLVRGENVTNEQAEMGEKIFSATGRIMWVPEK NINALTAISGSGPAYFYLFAESLIKAGVESGLSEEEAEILVLETLIGSGKMIAESDKS PGKLREEVTSPNGTTFAALNVFMDENLAQTVLKAVKACARRAEDLEGEYSE" gene complement(9178..10239) /gene="" /locus_tag="" /db_xref="3654422..3655483" CDS complement(9178..10239) /gene="" /product="3-isopropylmalate dehydrogenase" /translation="MPKVLVLPGDGIGLEITPQAVKVLEAVLKNHSTSLSFEYGLIGG AAIDEAGKALPDETLAAAQAADAILLGSVGGPKWDTLPAPQRPELGGLLAIRKALGLF ANIRPVKMLPMLVEASTLRPEVVKNVDLVVLRELTGGLYFGEKGRGTEPRSAFDTLIY TEEEIRRIVDLGFQTAAKRRGKLCSVDKANVLESSRFWREITLEVAKNYPDIELSHMY VDNAAMQLVRWPEQFDVIVTENMFGDILTDLASMLMGSIGMISSASLSGSKGLYEPAH GSAPDIAGKNIANPLATILSAALMLRYSFGLEQEAQKIEAAVERVLQEGYRTPDLAKP GDKVLGTKEMGNAVVAALK" gene complement(10270..11802) /gene="" /locus_tag="" /db_xref="3655514..3657046" CDS complement(10270..11802) /gene="" /product="2-isopropylmalate synthase" /translation="MRRIEIFDTTLRDGEQSPGVALNAEEKLQIAHQLGKLGVNVLEA GFPIASPGDFAGVRRIAQEVRNVSVAALARANAKDIECAWEAISEGESPRIHTFIATS PIHMRYKLQKSPEEVLEQAVQAVRLAKSKVSDIEFSAEDASRSDVDFLAKVFSGVIQA GATVLNIPDTVGYATPEEYAAFLRAIMEHTKGIEKVKVSVHCHNDLGLAVANSLAAVG AGVHQLECTVNGIGERAGNAALEELVMALHTRKDQFKAETSIVTSEIARTSQLVSRLT GMMIQHNKAIVGKNAFAHESGIHQDGMLKDRSTYEIMSPSIIGVDAESIVLGKHSGRH AVQQRLTDLGLELDESRFEELFSRFKLLADRKREVTTADLFSLVEEQKEKTDQITLDY LQVSSGTHLVPTATVGLQYEGQRLADAACGDGPVDAAFKAIDKVLGTQGILSHYSLQA LDGGEDAQGEVTVTVRFGENLVAGRGVSTDIIEASVRGYLQAVNRAFVRGWVKICENN AS" gene complement(11936..12934) /gene="" /locus_tag="" /db_xref="3657180..3658178" CDS complement(11936..12934) /gene="" /product="ketol-acid reductoisomerase" /translation="MAKMYYEVDANLELLKGKVIAVMGYGSQGHAQAQNLKDSGLNVI IGLRPGSARTERAQAAGFEVMTVEEAAKRADVIQILLPDETQSKVYQEEIKQHLTSGK ALVFSHGFNIHFGQIVPPSDVDVFMVAPKSPGHLVRRTYTEGAGVPALIAVHQDATGK AKELALAYAKGIGSTKAGVLETTFGEETETDLFGEQAVLCGGASELVKAGFDTLVEAG YQPEIAYFECLHELKLIVDLMYEGGMSWMRYSVSDTAQYGDMTIGKRIVNEETRKEMK RVLQEIQDGRFAKAWLLENQANRPTFNAMTRIEANHPIEKVGEQLRGMMSWLKKHE" gene complement(13011..13490) /gene="" /locus_tag="" /db_xref="3658255..3658734" CDS complement(13011..13490) /gene="" /product="acetolactate synthase small subunit" /translation="MLHTLAVLVENNPGVLIKVAGLFTRRGYNIDSLTVCQTEDPELS RMTIVVNGDDQIIEQVRNQLGKLVVVHSVSDFTGQSVVDRELALIRVEVTPETRSAVL QTVDIFRGRVVDMGRTNLTVELTGDIPKIDAFVHAIQPYGLLELVRTGKVAILRSQA" gene complement(13495..15183) /gene="" /locus_tag="" /db_xref="3658739..3660427" CDS complement(13495..15183) /gene="" /product="acetolactate synthase large subunit" /translation="MSEEKTGLVGATILLNALQEEGVDVIFGYPGGVLLPLYNALLDS SIRHILTRHEQGAVFAADGYSRVTGKVGVCLGTSGPGATNLVTGIANAFLDSIPLVVL TGQVPTGSIGSDSFQEVDIIGITMPITKHSYLVKDARDLPRIVREAFYLARTGRPGPV LIDLPKDVLAAEDVIPFSNEMKLKGYKAFGQGKNGKIEEVVKALSESSKPVLYAGGGV VTAGAEEVLRQFVDKTSIPVVTTLMGIGSLSLEHPNSLGMVGMHGTVTANYAVDDCDL LIAVGVRFDDRVTSGIGNRFATKAKVIHIDIDPAEVRKVVKTDIQIIGDARQVLTEIM EVLPGFSAPRVEEWWKQLHDWKKNHTLDYDKNRLTPQVVIQTLGEVAGGDTIVTTDVG QHQMWAAQYYPAVDPRNYATSCGLGVMGYGVPSAVGAQIARPGEPVLVITGDGSFQMS IQELGTIAQNQLPIKIILLNNGVLGMVRQMQKMFYDGRYNQISLQGNPDFVKVAEGYG IHGIRVNALEELRSAFEEAFKHPGPVLVEIPISEDENVLPMVPPGKLITEMIVR" gene complement(15219..16085) /gene="" /locus_tag="" /db_xref="3660463..3661329" CDS complement(15219..16085) /gene="" /product="branched-chain amino acid aminotransferase" /translation="MIIYLNGAFVSEEDAKISVFDHGFLYGDGIFEGIRAYHGRVFKL NEHLKRLYESAKSINLTIGLTKEEMQEVVLETLRKNELKDAYIRLVVSRGKGDLGLDP QKCSKATIICIAAQIKLYEKSMYEQGLNVKTVAIRRNNPDSLNPRIKSLNYLNNILAK IESTQAGVIEAIMLTQDGYVAEGTADNIFIYRDNVLLTPPLSAGILEGITRNSVIELA KDLDIKVREELFTRHDLYTADECFLTGTAAELIPVRNVDGREIGIGEPGPIFKQLLEQ FRALTHVNGPEI" gene 16469..17761 /gene="" /locus_tag="" /db_xref="3661713..3663005" CDS 16469..17761 /gene="" /product="homoserine dehydrogenase" /translation="MPLKIGILGLGTVGCGVVKVLQQNAEDIETRTHSELQIKAILDR DLHREREISGDYLLTDQPEKVLQDPEIDIIVEVMGGIEPARTFILEALQHGKSVVTAN KDLIALHGHELLDAANAAGKDLYFEASVGGGIPIIAALKESLSANQITEVLGIINGTT NYILTAMAEQGRDYGEVLAEAQQLGYAEANPSSDVDGLDAARKLAILASIAFNSRVAL KDVFVEGISKITSEDLAYAAELGCTIKLLAIAKHHAEGIEVRVHPAILPLTHPLAAVK GVFNAIYVVGDAVGETMFYGRGAGSLPTGSAIVSDIMRIARNIQAKSTASINCTCYLD LPLKSVSDFYTAFYIRLLVKDEPRVLATLALLFAEANISFASIIQKPRGEHQAEIVLV THPCREGALQEALDSVKAYSKVLSIDNVIRFEKEDPKF" gene 17791..18693 /gene="" /locus_tag="" /db_xref="3663035..3663937" CDS 17791..18693 /gene="" /product="homoserine kinase" /translation="MFQVKVPATTANLGPGFDCLGMALQLYNTITVKTDRSFHISLAG TYKEGLPEDESNLVWRTMCHFWDFIHFPVPSVDLTFHNEIPPARGLGSSSAAIVGGLA AANFLAGSPCSSFELLQLANEIEGHPDNVTPALYGGVTLSVPTEKGVLPRVLAQAPKL KAVVVIPDTHLNTKKARGILPPEVPRQDAVFNISHVSLLTEAFIREEYSLLKEGMCDK LHQTQRAALIPGLLETLEAALQAGAYGSALSGSGPTLLALVPNTSNLEVSSSMLDMLR KHDINAQAMLLDVDSKGTLADVVD" ORIGIN 1 ctaattttct acacccatag actcccgcaa taactgccaa gccccttgac gataattagc 61 agtcagcgct cccagagaag tcatcagaca atctctatcc agcaaaattg cagtttctcc 121 ttgggactcg atccccttga cactctccgt cagaatttga agtccattag gtaattcagt 181 taatgagctg ccggttccga caatccacct aaagtgaatt gatagttcac aatatgattt 241 tacagcagcc tttaatgctt cggcagttag ctcagctctt aacgctatct cttcagatgt 301 ttcaggttta gtttttatat gtttattcct gttcgtacta tggctttcaa ccaatggtaa 361 ggagtttgaa gttactgagt ataccgtgat tgattcttct tcaagtttaa gtactaaaac 421 atctcctacc tcttcatata taagctgaac tgctatcatc attgcttccg aagcaggtaa 481 aatcccttca ttaaaataat ttgaagcaat acccttggaa tttaagcctt caaattgtat 541 gggataaaca gcataaaatg gcatatcggt tattgaaccc caaggaccga tctctttttc 601 taagtcagcc atggcctgtt tgactcccag actaatatcc ccttcctgaa cggtcgtagg 661 aaaagttcct tgaccaagca gctttggatt ctcagaattt aaattaccaa aagcattcac 721 aacagttatt tcactacaaa tttcagcaac taacaccttt agcatatctt ctcctcactt 781 tgaataattt ttccatttaa ttatccttcc cttaaataaa aaaagtacgc aagctaaaac 841 tgctggttaa actttctatt ccaaccaaca acttgtacta tctttttaag tagtcagcat 901 gtatactctt ccttacaaag ctttgaagac ggcaagcaat aagaaaggag caatataagt 961 gaaaaaaagc ataatactat tagttttagt ggtattagcg tttttctcct cagcttcagt 1021 aactcaagct gcagtattta aggttggatc agcaggatcg gatattcgtg ttttacaatc 1081 agaacttcaa accttaaact atgatgtcgg tccggtagac ggcattttcg gaagtaaaac 1141 tcgggctgca gttgaagctt ttcaacgcga ccataattta atggttgacg gcatcgttgg 1201 tcctcaaacc caaaaggccc tggatgatgc aaatattcag ccatcagaaa aaacacagcg 1261 ttctgagaca acggaacaga ttattaatac cgctaaaagt ttcttagggg tcccatacaa 1321 atggggaggc gcttcaccag atggctttga ttgttctgga tttacaagct atgtttttgc 1381 cacccaaaat atatccttag cacgcgttag tcttgatcaa tatagaatgg gaacttctgt 1441 aagctttagt gatctggctc cgggagattt agttttcttc acctttagtt caagcaaact 1501 agtaagtcat gtgggcatct atattggtga caaccagttt atcagcgcaa ccaatagtaa 1561 aggaattgcg atctacagct tttctccata ctggagcaac gcctatgttg gcgcaagacg 1621 tgtttactaa ggcttgtgaa aaaaattcta taacaattat taaggccacg cgaaagcgtg 1681 gcctttaaac atacaatttt tcttttaatt ctactgataa aaccatgcaa aatgttttgg 1741 aatactaaca aataaagttt cgttacatac ttcctggtac atgaattatt tcatataaaa 1801 ttcaaagtct tgcttagcca ttctttcttc ccaatccatc tgcagcagct ctaactcatc 1861 agagtagtct gttttagttt catccttttc atattcgaga ttttccaata tgcggaatgt 1921 gaaattagct tctccgtatt ccttccattc cttttgtaat tctcgatttg gatatgagcc 1981 gaaatccaat tgaaatttca ccctgtttat agttgcattc agcctgagcg ttccctcaat 2041 aagacatttg ttgttacgat ttgagcgaat cataaaaaca cccatctcag gcttcagctg 2101 ccggtattgc tcttttaatt ctttctttct gttcatgtct aatatcccat ctccctcaga 2161 attcgtgcca gggttcttaa acgctcgcca atcagctcat catccacact tagtacctga 2221 ttaaatagtt taatatcttc attgattttt tcgttgtctg tacatacggc aaccgtcatg 2281 gcatctccct gtaaaccaac tctgtctata acaggatttt cggtatcata tagttcctga 2341 tatcgataag catcacgaaa atggagcttc gtcctggata tcaagatagc aagatcaagg 2401 actctgtgca gcggcaattc ctctgattgc ctagaccact tttcgccggt atacctccat 2461 actttagccg atacatcaac ttttccccga tcattccact gtgctaagcc taaggaaaga 2521 cctttcgcat cagaattata agcgtatcgc ccatcaacat tttcatagtt ctctgaaacg 2581 atcactggtt tatgcttaag ggtggttggt attttcatga ttttatcctc caatttacga 2641 ttcagtgtta gtatgttagt agttcagtaa attactaatt tactgaacta ctaacaagta 2701 taaaaaccct gcctcgaaaa gtcaatagtc taagccatcg tgacttgaac atgctgtaag 2761 aattaaaata atcgttatgc cccgtgacgc attataaagt ttagttctta aaaatcagcg 2821 acttaaattc ttaggaaatt cttaagttta gataaaaagc atttaaggaa aaaccgacct 2881 aaataaaagg gaacttttgc caactgcaaa agttcccttt tatttaattc cagcaaatat 2941 tatctctacc gtacatgcct gcagatataa ctttcagcgt tacgacagtc ctgtcaaacc 3001 tttaagcttc tctcttaaag gtttaagttt tgctaaaagc tcgtgatact ccttatctaa 3061 ggcttgcata tcatcctttt tccttggtat ggacaatctg cccaccactt ctgtgagacg 3121 atgctgcaaa ataagaacct gcttttcaag atcctctctc ccatcatccg aagacctatc 3181 cttttgagcc aggtagtctg catagcttcc ctgaaacatt tgaattccct gattttctat 3241 ggtcatgata tgatcagcta ctgaacctat tagacttcga tcatgagaga caaacaaaag 3301 cgttcgatta taacctcgca gagcctcctc tattacttca agagaattaa tatccaaata 3361 attggtgggc tcatctagga taagcaagtt aatatcttgt aataaaatct tggcaaacga 3421 aactttaact cgttcccccc cgctcagcag gcctacttgt ttatataccg catccccctt 3481 gaggagtaat ctcgccaaca gtgttcggac aaagctttcc tgataaatgc tttcctccat 3541 aacattttca ataatgctca acttatcctt aagaatagtc atgtcctggc tgaaatagcc 3601 gattttagct ccttgagcta cttttaagga atcatccttt gccaaaatca tttttagcag 3661 tgtgctttta ccgcagccgt taggaccaat caaggccacc ttggcgccat tttcaatctt 3721 gaactccgca tctctgaata tagcttcctt gccaaaggtc ttacaaatat cattgccttc 3781 aataattatc ttactataga gcatccctga gtctgtcacg tccagtttga tcctctgctg 3841 ttctgcaggc ttttctttaa cttctaagtg ttcgattcta gtttccgtac tttttatggc 3901 tcgatcaaga gaagccttgg ccttttgatc tcccatttta tgcagtcggg cctcagaatt 3961 gcccattctt ttaggggtct ttctcacatt tttgaccttt tgctttgtct cttccacagc 4021 tcccagtaat ctcttttttt ccttaatata ttgttgatac tcaaactgcc ttctttctct 4081 ttcttcctgc ttctgtacac aataatcgct gtagttgccg ggatagactt taagctcacc 4141 ctcttcaatc tccaggatct tgttgcacaa ctgattcaaa aaacgcctgt catgcgatat 4201 gagaataagc ccactacggt gctccgccaa ccggcgttcc aatagttcaa tcccttccag 4261 gtccagatta ctggttggct cgtcagcaaa aattaaagga caatcctgac tcaagctttg 4321 agcaagctta aagcgggtgg tttctccgcc gctcattgtc tcattccagg tgcttgaaat 4381 accaaattgt gcggccagct cagcactggt ctgcttttgc tccggtggat caagctggga 4441 tatataagcg cacttgccat acagcttaac ctgaccttca tcaggctcca ggcctttgct 4501 caatatcttc agcagcgtgg ttttgccaac cccattagca cctacaattc caatccggtc 4561 ttctgaataa accttaaaat tttcaagttg aataatcaag cgatcagcaa aatatttctt 4621 aagattactg cattcaacta ataaaataaa aacccctcct aaaccggaga ggatagtgtc 4681 atgaatgcca aatagcctgg agaccttagc acagacacag aaataccatg gccatgatag 4741 gaactcagaa attttggtaa tatccattca acaagctacc atcagtttag aaaacactat 4801 ccactcacag ttttaataaa atgcatgata cataagccgt agtaccacga cttaaaaatc 4861 tcatttaaaa aacataagtg aattagtgct tcattttctg ccagtacctt gcctttcatt 4921 aagttaatgt cacacctaca gtatagaaaa cttccttgct ttcgtcaact cattgacatc 4981 caatcagtcc gtaaagcttc atcacagtgg cccaattgcg ggtggtcaca gtatcgccca 5041 gtatgcgtcc cacttcagcc ggcagctggc tcttcaatat accgttggga caccagagat 5101 aagcaactcg ttcacccatt gccaaagcct caggcgccca atccttcctt gccaagtctt 5161 tgagcttatc cctatcctct ggtttttcta agaaagccac cagaaatctt gagggatcct 5221 tggctgcata atctaaggga ttctcagaga caacctgaac aagctcttgc tctgaaacca 5281 caataacttt ggcagaaacg cctagtttct ccaaaagccc aagctcgatt cgttgagcag 5341 acgttacggc atgagcctct atagccgtaa aaacaacatt gccgctatta agaatcgtgc 5401 gcacatcccc gttgcccaga cccaccacta gactgcgcaa atcagccatc gctacacgct 5461 ttgctcgccc gacattaatc ccacgtatta aagctacctg cttattgccc acgaacctca 5521 ctccatccga ttaatgccga attccagtca aattcccact aaaacttaga cgatttgtcc 5581 atcaccgtaa accatgtatt ttatggtggt cagttccttc agacccatgg ggccccgggc 5641 atgtaatttc tgagtactga tgccgatttc cgcaccaaaa ccgaatcgcc ctccatccgt 5701 aaatcgagtc gaggcattga cgtagactgc tgcagcatca atttccctca aaaaacgttg 5761 tgccctggag taattctctg taacaatggt ttccgaatgc ttggtgctgt attgataaat 5821 gtggtttaac gccccatcca aatctggcac tacttttact cccagaatca agtcgagatg 5881 ttcatatttc cagtcgtcct ctgttgccgg aagtgaataa gtcaagatat cgcaggttct 5941 ggggcagccc ttcagctgaa cattgagctt tttcagctct tccccgatta agggcaggaa 6001 ctctgcagca atcccttcat ccaccaagag tgtttccaaa gcattacaaa cccctgggtt 6061 ttgtgtcttg gcgttgacca cgataggaac agctttttca tagtccgcat ccctgtccac 6121 aaaagcgtga cacatacccg ttccggtttc aatcacaggt accgtcgagt tttgaactac 6181 agcttgaatc agaccggccc ctcctctggg gatgatgaca tccagaaatt cattcatacg 6241 gatgagcttc tgtacccatt ctctgcttgt ttcagtgatc agctgaatac atcccccagg 6301 caggccgctt gcttctgctg cttctgcaat cactcttgcc aatactttat tactctccag 6361 agcctcggac cctcctctta agatcaccac atttcccgat ttcaggcaca aggctgctgc 6421 gtccaccgtc acattgggcc gggcttcata aatcatggca accacaccta aaggtacatg 6481 tacctgctga atacgcagtc cattaggccg ggtccatatt tctccttctc ccaccgggtc 6541 ccgtaaggca acaacctctt ttagagattg acttatttgg gcaatacttg cggcagtcag 6601 tcttaaacga ttaaccaaac tttttttgag acctttttct tctgcagctt ggacatcccg 6661 ctgattagcc tcaagaattt cctcttgatt ctttaaaagg gcctccgcca tagcaagtaa 6721 ggcattgttc ttagattctg tgctggcata agccaataaa cgagccgctt gtttagctct 6781 ttgcccaatc tcaataagtt ttgcctcaaa catagttttt ccctcctaaa attattgtgt 6841 cgaagcctat tacatatcca ccatcactgt catattatct cgatggacca cttcctcccc 6901 ttcaaaattt tcaatgagtt catggagctt cccggagtgc atccctttga cctggagtac 6961 ctcgtcgtga tttagctcaa cgactccttt cgcgatctcc tctcctcgac tattgagtat 7021 tctcacaatt tccttccgtt cccaagttcc ggagacacct gttattcctt ttgccagcaa 7081 gctttttcct tcttccaaaa gggctttggc agctccatca tcgacgtgga tacagccttc 7141 agacaatccg gcataggcaa tccaacgttt ccttcctgcc aggcggtgct ttaccggctt 7201 aaagtaagtg ccctccgggg cctcaccctt ggtaagatcg tccaattcct tcaagcgtgt 7261 gaaattcaaa agaagagtac caatgccaaa gtgtgttgca attctcgccg ccctcagttt 7321 agtgaccatt cctccggttc ccaacatact tccggcccca ctggccatac attctactgc 7381 tgaaacctct gcaacttctt taatgagctg agctgattga tcttttttag ggttagccgt 7441 atataagccg tccacatctg tcaaaatgac cagcaaatca acgcctacca gcccggctac 7501 caaagccgac aaggtatcat tatcgccaaa gcacaactca tctacagcaa ctgtgtcgtt 7561 ttcattgata attggtacta catgcaagcg aagtaatttt tccagtgtat tttgagcgtt 7621 tctgtaatgg gatgcttgag ctaagtcgat tcgagacaac aaaacctggg ctcctacaat 7681 accatgctgt tcgaaattcc tggtatacat ctcgatcagc acaccctgtc caacggctga 7741 taccgcttgc ttgcccggca aatctctcgg ccggttatga agttttagac gtcccatccc 7801 agccgctacg gcaccggaag taacaataat acattccacg ccatgctttt ttaagtccgc 7861 aattgctgaa acgacttgag caatagcggc ttcatctaag cctccctggg gatggttcaa 7921 actactgctt cctattttca ggacaattct ccgaacccca ttcaaagtca ctctgaatac 7981 tctccttcca aatcctcggc acggcgggca caagccttaa ccgctttaag aacagtttga 8041 gccaggttct catccataaa tacatttaag gctgcaaagg ttgtcccgtt tggtgaagtt 8101 acttcctcac gaagctttcc cggggattta tcgctttcgg caatcatttt cccagatcca 8161 attaaggttt ccaaaacaag aatctcagct tcctcttcac tcagccccga ctcaacccct 8221 gctttgatca aactttcagc gaataaataa aaataggccg gtccgctgcc gctgatagca 8281 gttaaggcat tgatattttt ttcaggaacc cacataatcc ggccggtagc tgaaaagatt 8341 ttctcaccca tctcagcctg ttcattggtg acattttcac cgcgaactaa gcctgtcatg 8401 gaatgcagta cagccatgga agtattgggc atggcccgga tcactgctac tcccggcaga 8461 tacttggcga agacccttaa aggaacaccc gctgccacac tgatgaccaa cttgttctgt 8521 aaagaaaagg ccgttaagtc tttcagtaca ccttgaacat cctttggctt cactgcgata 8581 attacgacct gagagttttc cacaaggtct tgaagggatg ctgctgtcac atcatatctg 8641 tcaaccaggc cctggagacg tcctcggttg gaaagattcg tcactcgaat ctccagctct 8701 ttattggtct ttttaagacc gctgatcata gcttctgcaa tatttcctcc accaataaaa 8761 ccgatactgt atgacatttt attcgacaat cctttcttac actttatctt agctttagtt 8821 ttagctttag catcttttaa taatacaaaa aggccccttt catcctttat aaggacgaaa 8881 gaagccttcc gcggtaccac ctttattgcc tatgccaact taatcttgcc agatatgact 8941 aacaagactc ctaataacgg tggaagccgt ccgattcttc atcagagcat cacgactggg 9001 tttcaaatac cttaggcgga aaaactctca gcattttgtt tttctctctg acacctctgg 9061 ttatcctact gggtcgatca tttgctttat tcactatcta atttcttata ctctatctta 9121 atcattcaag aatatcaagt gcatagcaaa taattcctaa ttttttaaga tattgtttta 9181 tttaagagcg gcgacaacag cattgcccat ttctttggtt cccagtactt tgtcccctgg 9241 ttttgctaaa tccggagttc tatacccttc ctgcaggact cgttcaacag ccgcctcgat 9301 tttttgagct tcctgctcca agccaaagga gtagcgcagc attaaggctg ccgagaggat 9361 ggttgctaag gggttggcaa tattcttacc cgcaatatcc ggagccgatc catgggctgg 9421 ttcgtagagt cctttgcttc cgcttaagct tgctgaggaa atcatgccaa tggatcccat 9481 caacatagag gctaagtccg tgaggatatc tccgaacata ttctcggtaa cgataacgtc 9541 aaattgctcc ggccagcgta ccaattgcat agctgcatta tccacataca tatgacttaa 9601 ttcaatatcc ggatagtttt ttgcaacttc aagggtaatc tctctccaaa aacgagaaga 9661 ctccaagaca ttggctttat ccactgagca cagtttacct cgacgctttg ccgcggtttg 9721 gaagcccagg tcaacgatgc ggcgaatttc ttcctctgta tagattaagg tatcaaaggc 9781 acttcttggc tcagtgcctc tccctttctc tccgaagtaa agccccccgg ttagttcccg 9841 caagacaaca agatcaacat ttttgacaac ttccgggcgc agggttgaag cttccactaa 9901 catcgggagc atcttaacag gacgaatatt ggcaaaaagg cccaaagcct tgcgaatagc 9961 caacaatcca cctaattccg gacgctgggg agcaggcaaa gtgtcccact tagggccgcc 10021 gactgaacct aacaggatgg catctgctgc ttgagcagca gctaaggttt catcaggcaa 10081 ggctttgccg gcctcatcaa tagcggcccc gcctattaaa ccatattcaa agcttaagct 10141 tgtagaatga ttttttaata ccgcttctaa cactttaact gcttgggggg taatctctaa 10201 accaatacca tcaccgggca aaactaaaac cttaggcatt atttttactc ctttcaacat 10261 tgggatgtgt cagctcgcat tattctcaca aatttttacc cagcctcgta caaaggctcg 10321 attaaccgct tgcagatatc cccgtacact ggcctcgata atatccgtac ttacaccccg 10381 gccggcaacc aaattctcgc cgaacctgac agtgacggta acctcacctt gtgcgtcctc 10441 tccgccgtca agggcttgta aggaatagtg actcaagatt ccttgagttc ccagcacttt 10501 atcaatcgct ttaaaggctg catccacagg tccgtctcca caagcagcat cagctaggcg 10561 ctgcccctca tactggagtc ccactgttgc tgtaggaacc agatgagttc cgcttgagac 10621 ttgcaggtaa tctaaggtaa tctgatccgt tttttctttc tgttcctcga ccagagagaa 10681 cagatcggca gtcgtcacct cacgtttgcg atcggccaaa agtttaaacc gggagaacaa 10741 ctcttcaaat cggctctcat ctaattccaa gcccaagtct gtcagccgct gctgtacagc 10801 atgccgtccg gaatgttttc ctaaaacaat agattcagcg tccaccccta ttatgctggg 10861 cgacatgatt tcataggtgg aacgatcctt taacatacca tcttggtgta tgcctgattc 10921 atgggcaaaa gcgtttttcc ccacaatagc cttattatgc tgaatcatca ttcccgtcaa 10981 acgacttacc aactgactgg tcctggcgat ttctgaggtt acaatgcttg tttccgcctt 11041 aaactggtct ttgcgcgtgt gcaaagccat aacaagttct tctaaagcgg catttcctgc 11101 acgttcccca attccattaa cggtacactc taactgatga actcctgcgc ctacggcagc 11161 aagggaatta gccacagcca aacccagatc attgtgacag tgaacactga ctttgacctt 11221 ctctataccc ttggtatgct ccatgatagc ccgcaaaaaa gcagcatact cttccggagt 11281 tgcataccct acggtatcag gaatattcag taccgttgca cctgcttgaa tcactcctga 11341 aaaaacctta gccaggaaat ccacatcgct gcgtgatgca tcttctgcac taaactcaat 11401 gtcactcact ttggactttg ctaatcgtac ggcttggaca gcctgctcca aaacttcctc 11461 cggcgatttc tgaagtttat aacgcatatg tatcggcgaa gtggcaataa aggtatgaat 11521 gcgcggagat tcaccttcag agatcgcttc ccatgcacat tcaatgtctt tagcatttgc 11581 ccgcgccaaa gcagcgacac tcacatttct gacttcctga gcgatcctgc gcacacccgc 11641 aaaatctccg ggagaagcaa taggaaaccc tgcttctaaa acattaactc ccagcttgcc 11701 taattgatgg gcaatctgca atttttcctc tgcgttaagt gctactccag gtgattgctc 11761 gccatctctc agggtagtat caaagatttc aatccgacgc attactccaa cttccttcca 11821 ataacattga atcaaccata agcaaataaa gaactgcaaa tcaccacccg ttagggcaat 11881 gatttgcaat catcagtgaa caaattctgt aacaatcccc cagaaactca tgagcttatt 11941 cgtgcttttt cagccagctc atcatgcctc ttaattgttc tcctactttt tcgataggat 12001 ggttggcctc aatgcgggtc atggcgttaa aggtcggacg atttgcttgg ttttcaagga 12061 gccatgcttt agcaaagcgg ccatcttgga tttcttgcag tacccgtttc atttctttac 12121 gggtttcttc gttaacaatg cgtttgccaa tggtcatatc cccgtattga gcagtatcag 12181 acactgagta tctcatccag ctcattccgc cttcatacat taaatccacg ataagtttca 12241 gctcatgcaa gcattcgaaa taagcaatct ccggctgata acctgcttca actaaagtat 12301 caaaacctgc tttaaccaat tcggaggctc ctccgcataa aacggcttgt tctccgaaaa 12361 gatcggtttc ggtttcttca ccgaaggtgg tttccaatac ccctgccttc gtggagccaa 12421 ttcctttagc ataagccaag gctaattctt tagctttgcc agtagcgtct tgatgaacag 12481 ctatcaaggc tggcaccccg gcaccttcag tataagtacg tctcactaaa tgaccagggc 12541 ttttgggagc aaccatgaac acatcaacat cacttggagg aacaatttgt ccaaagtgaa 12601 tattaaagcc atgagaaaag actaaagcct ttccagaagt taaatgctgt ttaatctctt 12661 cctgataaac cttgctttga gtctcgtcgg gaagcaggat ttgaatgaca tccgcacgct 12721 tggcggcctc ttccaccgtc atgacttcaa agcctgctgc ttgggcacgt tctgtacgag 12781 cactgcctgg gcgaagtcca atgatcacat taagtcctga atctttcaga ttttgagcct 12841 gagcatgtcc ctggctgcca tatcccatga ccgcaatgac tttgcccttt aataattcca 12901 gatttgcatc aacttcataa tacatttttg ccattttcta taactccctt tcaactttaa 12961 gccttttctc aaaaagacca tgtatattat aacacaaacg aaatctttct ctatgcttgg 13021 gatcttaaaa tcgcaacttt tccggtacgc actaattcga gtaagccata aggctgaatg 13081 gcatggacaa aagcatcaat tttgggaata tcccccgtta actccaccgt caaattggtt 13141 cttcccatat caaccacccg tccccggaaa atatccaccg tttgaaggac cgcagacctt 13201 gtttcgggag tgacttcaac cctgatcaag gccagctcgc ggtcaacaac actttgtccg 13261 gtgaagtccg aaactgagtg aacaaccact agtttaccca gttgattccg cacttgttct 13321 ataatttgat catccccatt aacgacgatt gtcatgcgcg aaagttcagg atcttctgtc 13381 tgacaaactg taagactatc aatgttatat cccctgcggg taaacagtcc tgctacttta 13441 attaaaacgc ctggattgtt ctctaccaat accgccagtg tatgcaacat attattacct 13501 cacaatcatt tcagtaatca gtttaccggg tggaaccata ggcaagacat tttcatcctc 13561 agatatagga atttccacaa gcacaggccc cggatgtttg aacgcttctt caaaagcact 13621 gcgcagctct tcaagagcat taacacgaat gccatggata ccatagcctt cagccacttt 13681 tacaaagtcg ggattgcctt gcaggcttat ctgattataa cgcccatcat agaacatttt 13741 ctgcatttgc cgaaccatgc ccagaactcc attattgaga agtataattt ttatggggag 13801 ttggttttgg gcgatggtac ccaattcctg gatggacatt tggaaagatc cgtccccggt 13861 aataaccagc accggttctc cgggacgggc gatctgagcg ccaacggcag aaggaactcc 13921 ataccccata actcccaggc cgcagctggt agcatagttg cggggatcca ctgccggata 13981 gtattgagct gcccacattt gatgctgtcc cacatccgta gtgacaattg tgtctccccc 14041 tgctacctct ccaagagttt gaataacaac ctgaggcgtt aagcgattct tatcatagtc 14101 aagggtatga tttttcttcc aatcatggag ctgtttccac cattcttcaa ctctaggagc 14161 agagaatccc ggcaaaacct ccattatttc cgtgagaact tgacgagcat cgccaataat 14221 ttggatatct gttttgacaa cttttcgtac ttccgccggg tcgatgtcaa tatgaatgac 14281 ttttgctttc gtggcaaaac gatttcctat tccgctggtt acccggtcgt caaaacgaac 14341 ccctacggca atgagcaggt cgcaatcgtc cactgcatag tttgcggtta cggttccatg 14401 cattcccacc atacccagag aattaggatg ctctaaggaa aggctgccga tacccatcaa 14461 ggtagtgaca acaggtatag aggttttatc cacaaattgt cttaaaacct cttccgcacc 14521 ggcggtgaca acaccaccgc cggcataaag taccggctta ctggattcag agagggcttt 14581 aacgacctct tcgatcttac cattcttccc ttgcccaaat gctttatatc cctttaattt 14641 catctcattt gaaaaaggaa tcacatcttc agcggccaga acatcctttg gcaggtcgat 14701 gagaaccggt cccggacgac cggtccgagc cagataaaag gcttctctga caattctcgg 14761 cagatctctg gcatctttca ctaagtaaga gtgcttagtg ataggcatag tgatgccaat 14821 aatgtccacc tcctggaaag aatccgaccc aatggagcct gtcggtacct gtcctgttaa 14881 aacaaccaaa gggatggagt ctaaaaaggc attggcaatg cctgtgacca gattggtcgc 14941 ccccgggcct gaagtcccta aacagacccc aactttaccc gttactcttg agtaaccgtc 15001 agctgcaaat acggcccctt gttcatggcg agttaatatg tgccgaattg aactatctaa 15061 gagggcatta tacagtggaa gcagcacccc tcccggatag ccaaagatga cgtcgacccc 15121 ttcctcctgc aatgcattta ataaaattgt tgcacctact aatcctgttt tttcttcact 15181 catacatttc cctccctaaa ctttcttcct ataagatgtt aaatttcagg accattgaca 15241 tgggtaagcg ccctaaactg ctctaaaagc tgtttaaata ttggtccagg ctctccaatc 15301 ccaatctctc gtccatcaac atttctaacg ggaatcaatt cagcagctgt tccggttaga 15361 aaacattcat cggctgtata caaatcatga cgagtaaata actcttccct gactttaata 15421 tcaaggtctt tagcaagttc tatgacagaa tttcgggtaa taccttccag aattcctgcc 15481 gatagcgggg gagtcagcaa gacattatct cgatatataa aaatattatc cgcagttccc 15541 tctgctacat aaccgtcttg ggtcagcata attgcttcta taacaccggc ttgagtactc 15601 tcgattttag ccagaatgtt gttaagataa ttaagggact ttatcctcgg atttaaggaa 15661 tccggattat ttcttcggat agctacagtc ttaacattta agccctgctc atacatgctt 15721 ttctcataaa gcttaatttg ggcggctata catataatcg tcgctttaga acatttttga 15781 ggatcaagtc ccaggtctcc cttgccacgg gaaactacca agcgtatata ggcatccttc 15841 aattcatttt tgcgcagggt ttccaaaaca acctcctgca tttcttcctt tgtcaaacca 15901 atggttaagt taatcgattt agctgattca tataatctct ttaaatgttc attcaatttg 15961 aaaactcggc catgataggc acgaattcct tcaaaaattc cgtctccata taaaaagcca 16021 tgatcaaaaa cagatatttt ggcatcttct tccgaaacaa aagccccatt taaataaata 16081 atcatcttca actcaccttt cacatgctgt cggcaatttt tctgtcgaga agctttctgt 16141 ctacaaataa aaacccaagc gcagtccctt gtaacgtgga actttccgct tgggtttttt 16201 ctacccacgg tgtaaaccca ttatggattc tgtaccgctt ggaccagaca ggttatcccc 16261 ggaaccctag gtacacttcc ttttctgtta tattacattt aaaacgagaa cgttgtgtat 16321 atgatacaga atacacacct cagtgtcaac cctaattttg tataattaag cgaaattcct 16381 tgctaaaatt ccttgtcaaa gcaagttgta acaaggtata atgtccacta tgcagataca 16441 tttgtttttt cgagaggagt tgactatcat gcccctaaaa ataggcatat tgggtttagg 16501 tacagtaggc tgcggggtcg tcaaagtgtt acagcaaaat gctgaggaca tcgagactcg 16561 tacccacagt gagctgcaaa tcaaagcaat ccttgaccgt gatcttcacc gagaacggga 16621 gatcagcgga gactatctcc tcacggatca acctgaaaaa gttcttcagg accctgaaat 16681 cgatattatc gttgaagtta tgggtggcat cgaacctgcc cgtaccttta ttttagaagc 16741 tttgcaacac ggaaaaagcg ttgttacggc taataaggat ttaatcgctc ttcacggtca 16801 tgaactcctg gatgccgcca atgcggcggg aaaagacctt tactttgaag caagcgtggg 16861 cggcggcatt cccattattg cagccttgaa agagtctctc tccgccaatc agattaccga 16921 agtacttggt attatcaatg gaacaaccaa ctatattttg actgccatgg ctgaacaggg 16981 acgtgactat ggggaagtgc tggcagaagc tcagcagcta ggctacgctg aagcaaatcc 17041 ttcttcagat gtggacggcc ttgacgcagc ccgcaaactg gccatcctcg cttccatcgc 17101 ttttaattcc cgggtcgccc ttaaagatgt ctttgtagaa ggtatttcta agataactag 17161 tgaagatctg gcctacgctg ctgaacttgg ctgtaccatt aaacttctgg ccatcgctaa 17221 gcatcatgct gaaggcattg aagtacgtgt ccatcctgct attctccctc ttacccatcc 17281 tctggcggct gtcaagggag ttttcaacgc tatttatgta gtaggagatg cggtaggtga 17341 aaccatgttt tatggccgtg gtgcagggtc cctgcctacg ggaagtgcca ttgtctccga 17401 tattatgcgt atcgcccgca acattcaagc caagtccacg gcttccatca actgcacatg 17461 ctatctggac ttgccgctta aatccgtctc agatttctat actgcctttt atatccgcct 17521 tctcgttaag gacgaacctc gtgtcctggc aactctagct ttgctctttg ctgaagcaaa 17581 cattagtttt gcttccatca tccaaaaacc tcgcggagaa caccaggctg aaattgtcct 17641 ggtaacccat ccatgccggg aaggagctct tcaggaagcc ctggactctg tcaaagccta 17701 cagcaaggtc ttaagcattg acaacgtcat tcgttttgaa aaagaggatc caaaatttta 17761 aggtcggaat catataaggg gaggaatata atgttccagg ttaaggtacc tgctaccact 17821 gccaatctcg ggccaggctt tgattgttta ggtatggccc tgcagctcta taatacaata 17881 actgtaaaaa ccgaccgctc ttttcacatc tcattagccg gtacttacaa agagggactg 17941 ccggaagatg aaagcaatct tgtatggcgc actatgtgtc atttttggga tttcatacac 18001 tttcctgttc cctccgtcga tctgactttt cacaatgaaa tcccccccgc cagaggttta 18061 ggcagcagtt ccgccgccat tgtcggcgga ctggcagccg ccaacttcct agccggatcc 18121 ccctgctcct cctttgaact cctgcaactg gccaatgaaa tagaaggaca tccggacaac 18181 gtaactcctg ctctctatgg aggtgttacc ttgtctgtac ctacggaaaa aggagtgctg 18241 cccagggttt tagcacaggc acccaagctc aaagccgttg tggtcattcc cgatacccat 18301 ctcaacacta aaaaagccag gggaatttta cctccggaag ttccccgtca agatgccgtt 18361 tttaatatct cccacgtatc cttgctaacg gaagccttta tccgtgaaga gtattccctc 18421 ctcaaggaag gaatgtgtga taaacttcac caaactcaac gagcagccct tatcccagga 18481 ttactggaaa cacttgaagc agccctacaa gccggagcct atggttctgc tctcagcggt 18541 tcgggcccta ctctcttggc tcttgttcca aacacctcta atttagaggt ttcctccagc 18601 atgctggaca tgctgaggaa acatgacatt aatgctcagg ccatgctttt ggacgttgat 18661 tccaagggta cgttagctga cgtagttgat taa //