LOCUS NC_015732:15 18235 bp DNA linear BCT 11-OCT-2011 DEFINITION Spirochaeta caldaria DSM 7334 chromosome, complete genome. ACCESSION NC_015732 SOURCE Spirochaeta caldaria DSM 7334 chromosome, complete genome. COMMENT locus start: 2710913; locus end: 2729147 FEATURES Location/Qualifiers source 1..18235 /organism="Spirochaeta caldaria DSM 7334 chromosome, complete genome." gene 0..509 /gene="" /locus_tag="" /db_xref="2710913..2711422" CDS 0..509 /gene="" /product="putative cache sensor protein" /translation="MKRIIMSILISISMVILLDNVIAQTKSKIDPEKEKKVINLVNSG ITFIQKNGIDKAVKAFQDTKGGFIDGEFYIFLYDLEGNALVVGSNTSLIGKNLMNISS TDRNGNKVYQVKELINIAKTKGEGWFEWAWQNPETKKFGPKRGYAKRIDVEGKSYMIG SGYYVGDED" gene 574..2370 /gene="" /locus_tag="" /db_xref="2711487..2713283" CDS 574..2370 /gene="" /product="methyl-accepting chemotaxis sensory transducer" /translation="MKFSFNNRTLFQKLLCIPVLIVVVFSIITGFFFFNQRQIQLTMK YFNNSLNYYEKSLEFTTLLTSSFERMLLAAQYYTSGIHSEQKTIQEIDAIKKSLKDLQ NTFVIFKDILSDELYQKTQHAITVYLEFSQYYLDSILIEASVVAGYLPSLHESFVVLE DIITESNDRIEEDFNKTKVDLTNLLTTFATFLIFIMLLSAVIFFSLSFSISNAIVKRM IQILTFMKDLSAGNLTSDIQDPYKDEIGNIIRLCHDVRSYLTTMVKNIEQVIISNRNV VEQLSHQSSEFTSAIEEMRSQTDIMNKNTGLLHEEIDSASKATEEIKKEIDDIVKTIK QQFSLNQQVTDFISLFIDDIYAISQLTNEKIHITRELIAKTTTAEEVVNDYHILMDEM KKSTEAISEMISIINNVAEQTNLLALNAAIEAAHAGEAGKGFAVVADEIKKLSELTKE RVDTAGMSLRDLIEKIHRGSDYSTDTQHIIGEILNGIKTVAASVEEIGTVMNTTNEKN IQIKEMVTQLKEITSNINNASKTIDARTNLINISIEKVRNLSLEHKSGIGEITIGIQQ IFELTPTLTALSKTNQDNNLILEKEIKEFTIQ" gene 2655..3365 /gene="" /locus_tag="" /db_xref="2713568..2714278" CDS 2655..3365 /gene="" /product="phosphoribosylaminoimidazole-succinocarboxamide synthase" /translation="MYAKGPQLYEGKAKKVFATTDPDLVIIHYKDDATAFNGEKKGQI EDKGVMNNRITSILFSHLAQAGIPTHFIEQLNDRDMVCKKVTIIPLEVIIRNVAAGSM SKRLGVAEGTELKTTVFEISYKNDALGDPLINDYHAVAIGLASFAELEEIYHLAGRIN ESLKVFFLERGIRLIDFKLEFGRTSQGELVLADEISPDTCRFWDAATNEKLDKDRFRR DLGNVKEAYIEILSRISR" gene 3384..4793 /gene="" /locus_tag="" /db_xref="2714297..2715706" CDS 3384..4793 /gene="" /product="amidophosphoribosyltransferase" /translation="MRDEQLSEQFYTEDKLHEECGVFGVYSSKTDRNVAPLVYYGLFS LQHRGQESAGIAVAHDGSIECRKGMGLVGEVFDPATLSQLSGPLAIGHVRYSTAGSST IENAQPFVSRFKLGSIAVAHNGNLTNATVVRELLEDAGVGFVSSSDSEVIINLIAKNY KKGLEKALTDTIQFIKGSYALVVMTESCLVGARDPHGIRPLCLGKIDEGWVLASESCA IDAVGGEFVRDIDPGEIVVIDQNGVLSFRFGERTRKAVCAFEYIYFARPDSTIDSVDV YQARIRAGEILGREAVVPADIVIGVPDSGVPAAIGYGRATGTPFGFGIVKSKYVGRTF IAPSQDERERAVSVKLNVLKSEVAGKRVVIIDDSIVRGTTSRRLVMLLRQAGAKEVHF RVCSPPVRFPCYFGIDTPHRKDLIGNANSVEEICKAIGADSLAFISTGGLLEALNGEN GYCLGCFTGEYPAPTPGEA" gene 4876..6075 /gene="" /locus_tag="" /db_xref="2715789..2716988" CDS 4876..6075 /gene="" /product="phosphoribosylformylglycinamidine cyclo-ligase" /translation="MDYKEAGVDITEGYRAVERYKDLAAGTLTDGIVARSVINEIGSF AGMLSLKELIHAGKGMDDPVLVSGTDGVGTKLDIAFRMKKYDTVGIDCVAMCVNDVLC HGARPLFFLDYLACGKLDAEIAAALVKGVAIGCRETGSVLLGGETAEMPGFYDEGKYD IAGFSVGIVDRKNIVKGEKIQIDDVLLGLASSGPHSNGYSLIRKAIPDLDEDFGGMPI GYALLEPTRLYVKPILALMEKIEIRGMAHITGGGFYENIPRMFAEPRTAIIRNGSWPI PPIFARIAYGAATGGKGPLRGGAAQEAGAQLLQKDEALRHSMFNTFNMGIGFVIAVRG EDAQTAIEFLDSQGYPAFVIGRVGPYPLGSQTMGSNPMGAKGSGTEPDAGPKSGKNPG LGEVQFE" gene 6068..6721 /gene="" /locus_tag="" /db_xref="2716981..2717634" CDS 6068..6721 /gene="" /product="phosphoribosylglycinamide formyltransferase" /translation="LNKNAVTGAAATEKKVSVAVLVSGNGTNLQALLDAERAGRLAQA SIKLVISDRPGAYALERAKQAGKPAMLIEPNRSIPRDERRLDLSNRILAAVQNTGVEL IVLAGFLSILQGPILEYYRGRIINIHPSLLPKFGGPGMYGERVHQAVLEAGEMVSGCT VHIVDQGTDTGPILLQRTVPILPQDTPDSLANRIHSEEHIAIVDGVIELVTRLGYTT" gene 6765..8492 /gene="" /locus_tag="" /db_xref="2717678..2719405" CDS 6765..8492 /gene="" /product="Bifunctional purine biosynthesis protein purH" /translation="MKKRALLSVFDKTGIAELARFLVQQDWELLSTGGTAKYLKDQGL PVTDVSAVTGFPECLDGRVKTLHPAIHAGLLARRDLSEHMETLKTLGLGTIDLVCVNL YPFFEKVQAGLSLEDTVEFIDIGGPTMLRSAAKNFAHVLVLTDPTDYAEVQNYLSAGE VPIAFRKRLAGKVFNLTSAYDGAISRYLLEETYPQYWPLSLVKKQSLRYGENAHQSAA LYVHTDSPGALGTMEQLQGKELSYNNIRDLDLAWKAACALGVRFPKGTIVPPLGYIDE ELIGRPAASQQGSSAGTSSDSAAAVVPTAATPVAANFPVADFSATANPATADFLPACV AVKHNTPCGVALGSTLLEAYEKAYACDPVSIFGGIVACTSTVDAATAQRLAELFLEIV VAPDFTSEALEIFRAKKNLRVMRATLPPQDRMECISVDGGLLVQSRDNRLIEKWEVVT QKAPDPSDIDDMLFGMRVVTYVKSNAIVVVKDGSALGIGGGQTNRIWAASQALERAAT VTGPADRARVLASDAFFPFADVVEAAAAAGITTIIQPGGSIRDKESIEAADRLGIAMV FTGCRHFKH" gene 8523..9905 /gene="" /locus_tag="" /db_xref="2719436..2720818" CDS 8523..9905 /gene="" /product="phosphoribosylamine--glycine ligase" /translation="MKVLVIGSGGREHALAWKLAQSVRVTTVYVAPGNGGTALEHKCR NVPVPGSDPSRPEAQEYLVDFVRREGIELTVVGPEAPLAAGLADRFTAAGLPVVGPEA KTAQLESSKAYAKAFMAKYGVRTARSTTVNTLESAMALVTEHFAGNPPHKPTGRPLVI KADGLAAGKGVVITDRADEASATIEEFMEHRALGTAGTTLVIEEYLEGKEVSILAAVQ AGPDLAPGTARILPFIPARDHKRRYDGSQGPNTGGMGAIAPVADFSEAARTDFEKHIL EPTLRGLEAEGLSYRGFIFFGLMVQDNRCYLLEYNVRLGDPETQAVLPLMGSDLAELC LSIAGGTLHQYNLTWKPGFVCAPVAVAEGYPGTYRKGDPISIERDKIAAAGAQVFIAG ASMNQKALDTGTPDSGDGEGSLLRTTGGRVLAVSAYGTNLEDARSRAYQGMDGVHFTG MGFRRDIGTC" gene complement(9938..10525) /gene="" /locus_tag="" /db_xref="2720851..2721438" CDS complement(9938..10525) /gene="" /product="TetR family transcriptional regulator" /translation="LLEAGEELLAQQGLPGFSMRKLGRLVGLSEAAIYRHFSNKDELV QTIIQRGYDRLLKTLEEILTDSSRSCIQKTVAAISAYINFALEQPDLFKVVVMQDAGP GKSQVNGLKRGISQSRKTFTLFVAVLSEGMKKGEFAPAPPEITAMTIWACLYGLASRL IIESPLDPELQNQIIQRFSQVILGGLIHGTSFTSL" gene complement(10703..11602) /gene="" /locus_tag="" /db_xref="2721616..2722515" CDS complement(10703..11602) /gene="" /product="ABC transporter integral membrane subunit" /translation="MKKRYNYESYIFNTVNGTIMVLFSVIMLYPFWNTVAVSFNEAVD TIRGGITLFPRRFTLQNYKMVFSTGAIFRAFFVSVARTVLNVLTNVFFTSMIAYVLSR PNFIFRRQFTVILVVSMYINAGLIPTYFLIKNLGLLNSFWVYVIPTMVSAFNFLVIRT FLRGIPESIIESVRIDGGSDYTIFFKIILPLSTPVLATVALFVAVGAWNSWFDTLIYA SSKVKLHTLQYKLMEFLQSSQAQSRGAGDIGAMGLSQQSNMVTPMSIRAAITVVAAAP IIVVYPFIQKYFVIGMNLGSVKE" gene complement(11599..12540) /gene="" /locus_tag="" /db_xref="2722512..2723453" CDS complement(11599..12540) /gene="" /product="ABC transporter integral membrane subunit" /translation="MMNVIPRQTRGGKLLTTIYTQRHLLVMSVPIILYVLLFSYVPLW GWTMAFQNFRPSKTFFQQEWVGLKWFRFLFSDPVFIRTIRNTFMMSIINTTLGFVSAI SFALLLNEIKNVAFKRITQTISYLPHFLSWVIVTGLVATMLSVEDGAVNNVLQFLGII KEPVLWLSEPKYFWGVIGATYVWKELGWNTIIYLAAIAGVDPTLYEAAEIDGCGRWRK MWYITLPSIKPTIIILIILSIGHILDAGFEMQYLLRNGLVQDVSDTIDIYVLMFGLQR SNYSLATAAGLFKNVVNMTLIFLANELVKRLGEERLI" gene complement(12620..14278) /gene="" /locus_tag="" /db_xref="2723533..2725191" CDS complement(12620..14278) /gene="" /product="extracellular solute-binding protein family 1" /translation="MKNMVRATGLMLGLVVFLFVTGCAKKNESASAVPTRKPITISVF TIQSRQQPNPDNKAYKYLKEKLGVTFEWDILVGELAQKRGVMIAGEDYPDVIEINETQ FIDAGALIPLEDLVEKYGPNIKAHFGDQWDKLRSPDGHIYYLTNWGIIHNKDQSPYYG ASAMWIQKEVLKEAGYPKVVTMDQYFDLLINYAKKHPTINGQKTIPFTILTYDWHAFC LWNPPNFLAGNPNDGNGVVNPNTLQYKTFFTMDISKRWFKKLNELNAQGYIDKAAFSD NYDQYLAKLATGRVLGMHDQRWQFQNADDALRDAGMYNRTFAPLPVVFDASIRPHYRD YPIPNLGRGVGISKKAKDPVRIIQFINDLLSEEVQRMMQWGIEGEDWQRNEKGEPYRT PEQRKNWENITWQEQNRALLVRDIFPNWEGSFNDGYPWDLTYYYPEREAITRPEDKEL WQAYGVTSYAELMDKNPPPNPIWYPTWNLPNPPDGSDAQIALQRCDQTMRKYLPKIIL APPADFEKLWAEYVDQMNKNGISIYEAYMEDQVKKRVAAWSKKK" gene complement(14433..16250) /gene="" /locus_tag="" /db_xref="2725346..2727163" CDS complement(14433..16250) /gene="" /product="Xenobiotic-transporting ATPase" /translation="MSEQTQFEEKEYSSQFDVTLWKKIFQFGKALYPVIGLLILIMIG VAVLDGIFPQMTRYALDVLIPIAQEPDSAPLISRFIFRYGLLALLQGFNVWALIMIAG IIEVRLVYTLREKAFQRLQQLSFSYYDRTPAGWIIARMTSDAQKLGDTIAWGIVDLVW GTTMMLTIIVFMVVMQPLLAAITLVFVPPLLVITFWFQKRILMAQRKARKANSIVTGA FNEGLQGGRTTKALGIEKYNYKEFAEKTQTLRNHSIRAARLSALFFPIVISLAAMGAA LALGAGGQFLLKGIISFGTLVAFINYALMFFDPAREVARVLSEFQAAQASAERLVGLI DTELEIVDRPNAREGVPICGELLLENIAFRYGKDAPWIFKNFSLYIPAGQTVAVVGET GCGKSTLVNLICRFYEPEEGSIQIDGRDYREWTQHWLHSQLGYVVQTPLLFSGTVREN IRYGRLDATDDEIEQAARDANAYAFIERLEQGFDTPVGEGGALLSVGQKQLICLARAL VANPRIIVLDEATSSVDTETEVLIQGAINRLLAGRTSIVIAHRLSTIRNADRIILMDK GRIIEDGDHQSLMALHGMYWKLYTQQFLSEDAFIQAAGV" gene complement(16264..18234) /gene="" /locus_tag="" /db_xref="2727177..2729147" CDS complement(16264..18234) /gene="" /product="Xenobiotic-transporting ATPase" /translation="VSVTTKELYSIQKNSWPRFGRINLLWNVLKGWRHIYALGLAAII GEVFFTFSSPMIVKLTIDSVIGTAPPIICFPLSVILEPFLGKNFEGGGFLEKLVPLQT LQAWGNAPWVWQPWLRDHLWVLGLAFAGMIFMQAFFSFIASLSVNTAAEQSAKALRDR LYHHTQHLPYETMLRSQTGDWLQRCTSDVDTVRRFFAFEFVELFRTLALVAFVFPIMF SLSYRLTLWGSIVMPVIILFSFYFQKMVERLFLVADEREGVLSGIVQENVTGVRVVRA FARQQYELERFGRANKGLRDQVYKLISWLGFYWGFSSFLGLLQIALLLGAGLKLYTAG FITIGLLVLFLTYEQQVLWPVRQFGRILADTGKTKVALGRIAELLTLVTETDLDSTIR VPAVSYSNAGGSFHDEWARGPIEFVDVSFSYPDGTEVLKHISFRVVPGEHVAIVGPTG SGKSTLMQLLVRFYEPNEGYITIGGRDIRTIPKAELRKAISLVLQDSFLFGKTVRENL LAACPDANEATLIDAAQKAAFHHVAMGFQDGYETMVGERGVTLSGGQRQRLALARALL RTAPILILDDSLSAVDIETDHLIRGAIGKQGRGTTTTFIVAHRLTTLAEADTILVLED GCITAQGSHEDLIQQPGLYRRLAELQSAFMDE" ORIGIN 1 atgaagcgta tcattatgag tatccttatt agtataagca tggtaatatt gttagacaat 61 gttattgctc agacaaaaag caaaattgat cctgagaaag aaaaaaaagt aattaacctc 121 gttaacagtg gtattacctt tattcaaaaa aatggtattg ataaggcagt aaaggctttt 181 caagatacta agggagggtt tattgatgga gaattttata ttttccttta tgaccttgag 241 ggaaatgctc ttgtggtggg aagcaataca agtcttatcg gtaaaaatct catgaacata 301 tccagtaccg atcgaaatgg taataaggta taccaggtga aggaattaat taatattgcc 361 aaaacaaaag gggaaggatg gttcgaatgg gcatggcaga acccagaaac aaaaaaattt 421 ggaccgaaac ggggttacgc aaaacgaatc gatgttgagg gcaaatcata tatgataggt 481 tcaggttatt atgtaggtga tgaagattag attaatttat aatcagggga ttatgttccc 541 ctgattccaa aaaaaattaa atttgtgagc catcatgaaa ttttcattca acaataggac 601 cttatttcaa aagctcctat gtattccagt tttaatagtt gttgtatttt caataattac 661 aggttttttc tttttcaatc aacgtcagat tcaattaaca atgaaatatt ttaataattc 721 attaaactac tacgagaaaa gtcttgaatt taccacattg cttaccagta gttttgagcg 781 catgctgtta gcagctcagt attacacctc gggaatacat tcagaacaaa aaacaattca 841 ggaaatagat gctattaaaa agagtcttaa agatttacaa aatacttttg taatttttaa 901 agatatttta agtgatgagc tgtatcaaaa aactcaacat gctattacag tatatcttga 961 gttttcacaa tactacctgg attctattct tattgaagca tcagttgttg caggttacct 1021 accatcactc catgaaagtt ttgttgtctt agaagatatt atcactgaaa gcaatgatcg 1081 aatcgaagaa gattttaata aaactaaggt tgatttaaca aatttgctta caacctttgc 1141 aacatttctc atttttataa tgttacttag tgctgtaatc ttttttagtc tttctttttc 1201 tatttctaac gcaatagtaa aacggatgat acaaattctc acttttatga aggatctgtc 1261 agcgggaaac cttactagtg atattcaaga cccctacaaa gacgaaattg ggaatattat 1321 aagactttgt catgacgtac gttcgtactt gactacaatg gttaaaaata tagaacaggt 1381 tattataagt aatagaaatg ttgttgaaca attatcacat caatcttctg aatttacctc 1441 tgctattgaa gaaatgagaa gccagacaga tattatgaac aagaacacag ggcttctcca 1501 tgaagaaata gattctgcaa gcaaagcaac agaagaaata aaaaaagaaa ttgatgatat 1561 tgttaaaact attaagcaac aattcagcct taatcagcaa gtgaccgatt ttatttcact 1621 ttttattgat gatatatatg ccatttcaca acttacaaat gaaaaaatac atatcactcg 1681 tgaactcatt gctaaaacaa caacggctga agaagtggta aacgactacc atatattaat 1741 ggatgaaatg aaaaaatcga ccgaagccat atcagagatg attagcatta ttaataatgt 1801 agcagaacag acgaatctgt tagcacttaa cgctgcaatc gaagcagccc atgcaggaga 1861 agcaggaaaa ggatttgcag ttgtagccga tgaaataaaa aaactttccg aacttaccaa 1921 agaacgggta gatactgcag ggatgtcttt acgggattta attgaaaaaa ttcaccgtgg 1981 gtctgattat agcactgata cccaacatat cattggggaa atcttaaatg gaataaagac 2041 agttgcagcg agtgtggaag aaataggaac tgttatgaat acaacaaatg aaaagaatat 2101 acaaataaaa gaaatggtta ctcaactcaa agaaattaca agtaatataa acaatgcaag 2161 taaaactatt gatgctcgta caaacctcat taatatttca atagagaagg tacggaacct 2221 ttcgttggag cataaaagcg gtattggaga aattacaatt ggcatacaac aaatatttga 2281 gcttactcct actctcaccg ctttgagtaa aactaatcaa gataacaatt tgattcttga 2341 aaaagaaata aaggaattca caatacagtg ataatcgcat ttcccccttg tcctgcaggg 2401 ttcctttgtg gtagtctgcg gctagacagt acaccatcgg tccatatatg ccccgtaata 2461 cggtcggggt gtttctacca gggagccgta aacctcctga ctatgggctg agaaacacat 2521 caggcaactc tcagaaaagt actttgagga gcatcagctc cgggagctta aacactccat 2581 tatatttttc tgaggaatgg ccattcattg cggaccgagc ggtatacgtc aatccaagac 2641 ggggagggtc cgcctatgta tgctaaaggt ccacagctct acgaaggcaa ggctaaaaag 2701 gtctttgcca ccaccgatcc agatctggtt attatccact ataaagacga cgccacagcc 2761 tttaacggcg aaaaaaaagg ccagatagag gacaaggggg tcatgaacaa ccgcattacc 2821 tctattctct tttcccacct cgcccaagca gggatcccta cccattttat cgaacagctg 2881 aacgaccgcg atatggtctg caaaaaggtt accattatcc ccctggaagt aattatccga 2941 aacgtcgccg ccggttccat gtcaaagcgc cttggtgttg ccgaaggaac cgaattaaaa 3001 acaacggtat tcgaaatctc ctataaaaat gatgctttgg gagatcccct catcaacgat 3061 taccatgcgg tggctatagg actggcaagc tttgctgaat tggaagaaat atatcacctt 3121 gccggcagaa taaacgaaag cctcaaggtc tttttccttg aacggggtat caggctcatc 3181 gattttaagc ttgaattcgg ccggacgagc cagggtgagc tggtattggc cgacgagata 3241 tcccccgaca cctgccgttt ctgggatgct gcaacgaatg aaaaactgga caaggaccgg 3301 ttccgccggg atctgggaaa tgtgaaagaa gcatacatcg aaattctgtc gcggatcagc 3361 cgctagcggc aaagggcaca gtatatgcgg gacgaacagc tctctgaaca gttctatacg 3421 gaggataaac tccacgaaga atgcggcgtt ttcggggtgt actcgagcaa gaccgaccgg 3481 aatgtggcgc ccctggtgta ctatggcctt ttttcacttc agcaccgggg ccaggaaagc 3541 gccggtattg ctgtagccca cgatggttcg atcgaatgcc ggaaaggaat gggcctcgtg 3601 ggtgaagtct ttgaccccgc aaccctttcc cagctttcgg gcccccttgc catcggccat 3661 gttcgctatt ctaccgccgg atccagtacc atcgaaaatg cccagccctt tgtcagccgc 3721 tttaaactgg gatctatcgc agtggctcac aacggcaacc tgaccaatgc caccgtcgtc 3781 cgggaactcc tggaagacgc gggagtaggc tttgtatcct ccagcgacag cgaagttatc 3841 atcaatctta tcgcaaaaaa ttataaaaag ggactcgaaa aggccctcac cgatacgatc 3901 cagttcatca aagggagcta tgccctcgtc gtgatgaccg aatcctgcct ggtgggagcc 3961 cgggaccccc atggtatccg gcccctctgt ctcggaaaga ttgatgaagg ctgggtactg 4021 gcaagcgaat cctgtgccat cgatgcggta ggcggcgaat tcgtgcggga tattgacccg 4081 ggggaaattg ttgtgatcga ccagaacgga gtcctttcgt tccggtttgg cgaacggacc 4141 cgaaaagcgg tctgtgcctt tgagtacatc tattttgccc ggccggacag caccatcgac 4201 tcggtggatg tttatcaggc ccgcatccgg gcaggggaaa tccttggccg ggaagcggtg 4261 gtccctgcgg atatcgtcat tggggtccct gattcagggg ttcccgccgc aatcggctat 4321 ggccgggcca cgggcacacc cttcggcttc ggcatcgtga aaagcaaata tgtaggcaga 4381 acctttatcg ccccaagcca ggatgaacgg gaacgggccg tatcggtgaa actgaatgtc 4441 ctcaaaagtg aagtggccgg gaaacgggtc gtgattatcg atgattccat cgtccggggg 4501 accacgagcc ggcgcctggt tatgctcctg cggcaggcag gagccaagga agtccatttc 4561 cgggtctgtt caccgccggt ccgatttccc tgctattttg gcatcgacac cccccaccgg 4621 aaggacctta tcggcaacgc caacagtgta gaagaaatct gcaaagccat cggcgcggac 4681 agcctggctt ttatttctac tggagggctc ttagaagccc tgaacggaga aaacggttac 4741 tgccttggct gtttcaccgg cgaatacccc gctcccacac cgggggaagc ataataatga 4801 gcatattagt gaaacgaaac aaaccagggc gcttctaaaa cttcagtttt agaagcgtcc 4861 acaacaagga agcacaatgg attataagga agcaggagtt gatattaccg aaggctaccg 4921 ggcggtagaa cgctataagg acctggccgc cggaacatta accgatggca tcgtcgcccg 4981 ttcggtcatc aatgaaatag gcagttttgc gggcatgctg tccctcaagg agctcattca 5041 cgccggcaag ggcatggatg acccggtcct cgtgtctggc accgacgggg taggcaccaa 5101 gctggatatc gccttccgta tgaaaaagta cgacactgtc ggcatagact gcgtcgccat 5161 gtgcgtcaac gacgtactct gccatggtgc ccggcccctc tttttcctgg actacctggc 5221 ctgcggtaaa ttggatgcag aaatagcagc cgcccttgta aaaggggtcg ccataggctg 5281 ccgggaaacc ggctcggtgc tcctcggggg cgaaacggca gaaatgcccg gtttctatga 5341 tgaaggtaaa tatgatattg ccggtttctc cgtcggcatc gtagaccgga aaaacatcgt 5401 gaagggagag aagattcaga ttgatgatgt gctcctgggt cttgcatcct caggtcccca 5461 ttccaacggc tacagtctca tccgaaaagc tatccccgac ctggatgagg acttcggcgg 5521 catgcccatc ggttatgccc tgctcgaacc taccaggctc tatgtaaagc ccatccttgc 5581 cctcatggaa aagatagaaa ttcgcggtat ggcccatatc accggcggcg gattttatga 5641 aaatatcccc cggatgtttg ccgagccccg aaccgcgatt atccgaaacg gctcctggcc 5701 gattccgccc atctttgccc ggattgccta tggtgctgca accggcggca agggccccct 5761 tcgcggtggg gcggcccagg aagccggtgc ccagctactc cagaaggacg aagccctgcg 5821 gcacagcatg ttcaacacct ttaatatggg catcggcttc gtcattgcgg tccggggcga 5881 ggatgcccag actgccatcg aattcctgga cagccagggc tacccagcct ttgtgatcgg 5941 acgggtcggc ccctatcctt tagggtcgca gactatgggg tccaacccta tgggggcaaa 6001 aggatccggc acagaaccgg atgcaggacc caaaagcggg aaaaatcctg gtctcggtga 6061 ggtgcagttt gaataagaat gctgtcaccg gagcggccgc gacagaaaaa aaggtttctg 6121 ttgcggtgct tgtctcaggc aatggaacga acctgcaggc cctcctcgat gcagaacggg 6181 ccggccgcct agcccaggct tccatcaaac tggtgatatc cgatcggcca ggggcttacg 6241 cccttgaacg ggcaaagcag gccggaaagc cggcgatgct tatcgagcca aaccgaagca 6301 tcccccggga cgagcggagg ctcgaccttt caaaccggat actggcggca gtgcagaata 6361 cgggcgtgga gcttatcgtc cttgcgggtt ttctgtccat actgcagggg cccattctgg 6421 aatattaccg gggaaggatc atcaatatac acccttccct cctccccaaa ttcggcggcc 6481 ccggcatgta cggcgaacgg gtacatcagg cagtactcga ggcgggggaa atggtttccg 6541 gttgcacggt tcatatcgtc gaccagggaa ccgatacggg gcccatactg ctgcagcgga 6601 ccgttccgat cctccctcag gatacgccgg acagcctggc gaatcggatt catagcgaag 6661 aacatattgc catcgtcgat ggtgttatag aacttgtaac ccgtctgggt tataccacct 6721 aaggggtact tttaaggtac ccatgggaca tacaaaggac gagcgatgaa gaagcgtgcc 6781 ctcctcagtg tttttgataa aaccggtatt gcagaacttg cccggtttct tgtccagcag 6841 gactgggaac tcctttccac cggcggaacc gccaaatacc tgaaggacca gggactgccg 6901 gtaacggatg tatctgcggt aacgggtttt cccgaatgcc tcgacggccg ggtaaagacc 6961 ctccatccgg ctattcatgc ggggctcctt gcccgacggg atctcagtga acatatggaa 7021 accctgaaaa ccctgggact gggcaccatc gatctggtct gcgtcaacct gtaccccttc 7081 tttgaaaaag tccaggccgg gctctcgctg gaagatacgg tagagttcat cgatattggc 7141 gggccgacca tgcttcgctc agccgcaaaa aactttgccc atgtactggt tctgactgac 7201 ccgacagact atgccgaagt ccagaactac ctttctgcag gcgaagtgcc gatcgctttc 7261 cgcaaacggc tcgcgggcaa ggtgtttaac ttgacctctg cctatgacgg ggctatttcc 7321 cgttaccttt tggaagaaac atacccccag tactggcccc tgagcctcgt aaaaaaacag 7381 agcctccgct acggggaaaa tgcccaccag agtgcagccc tctatgtgca taccgacagc 7441 cccggcgccc ttggcaccat ggaacaattg cagggcaaag aattaagcta caacaacatc 7501 cgggacctgg acctggcctg gaaggccgcc tgtgccctgg gggttcgctt ccccaagggc 7561 actatcgtcc cgcccctggg ttatattgat gaagagctca tcggccgccc cgccgcttcc 7621 cagcagggaa gcagcgccgg caccagctct gattcggcag ccgccgtcgt cccgacggcc 7681 gccacccctg tggccgccaa tttcccggtg gccgatttct ccgcgaccgc caacccggcg 7741 actgccgatt tcctgccggc ctgtgtggcg gttaagcaca acacaccctg cggggtcgct 7801 ctgggctcta ccctcctcga agcctatgaa aaggcctacg cctgcgaccc ggtttccata 7861 ttcggcggca ttgtggcctg cacttccacc gtggatgccg ccaccgccca gcggctggcg 7921 gaactgttcc tcgaaatcgt cgtcgccccc gatttcacca gtgaagccct cgaaatcttt 7981 agggcaaaga aaaacctccg ggtcatgcgg gcgaccctcc cgccccagga taggatggaa 8041 tgtatttctg ttgatggagg tcttctcgtt cagtcccggg ataaccggct tatcgaaaaa 8101 tgggaggttg ttacccaaaa agcaccggat ccatcagata ttgatgacat gctcttcggc 8161 atgcgggtcg ttacctatgt aaaatccaac gccattgtgg tggtgaagga cggctccgcc 8221 ctcggtatcg gcggcggtca gaccaaccgt atctgggccg cttcccaggc gcttgaacgg 8281 gcggcgacgg taaccggccc ggccgatcgg gcacgggtcc tcgcatcaga cgccttcttc 8341 ccctttgcag acgtggtcga agccgccgcc gccgcaggga tcaccaccat catacagccc 8401 ggcggcagta ttcgggataa ggaatctatc gaggcggcgg accgactggg cattgccatg 8461 gtctttaccg gttgccggca tttcaagcat taatattgca agcattgata aaggataact 8521 accatgaagg ttctggttat aggttctggt ggaagggaac acgctctcgc atggaagctg 8581 gcccagtcgg tccgcgttac aacggtctat gtagcaccgg gaaacggggg tactgccctg 8641 gagcacaagt gccgcaatgt gcccgtcccc ggctcagatc cgtcacggcc cgaagcgcag 8701 gaatacctgg tggattttgt ccgcagggaa ggcattgaac tcaccgtagt aggccccgaa 8761 gcccctcttg cggcggggct tgcagatcgc tttactgctg caggacttcc ggttgtcggg 8821 cccgaagcga agacagccca gcttgaatcg agtaaggcct atgccaaggc ttttatggca 8881 aaatacggag tacgaaccgc ccgaagtacc acagtaaaca ccctcgagtc agccatggcg 8941 ctggtgacgg aacattttgc agggaatccc cctcacaagc ccaccggacg acctctcgtc 9001 atcaaagcgg atgggcttgc ggccggcaag ggggtcgtta ttaccgaccg ggccgacgaa 9061 gcgtctgcga ccatagagga gtttatggaa caccgggccc tgggaaccgc cggaaccacc 9121 ctggttatcg aagaatacct ggaaggcaaa gaagtatcca tcctcgccgc cgtccaggcc 9181 ggaccggacc tggcaccggg aactgcccgg atcctgccct ttatacccgc ccgggaccac 9241 aaacggcgat acgacggttc ccagggcccg aacaccggcg gtatgggagc tattgcaccg 9301 gtggcagatt tttctgaagc agcccgtacc gattttgaaa aacatatctt ggaacccacc 9361 ctgcggggac tcgaagccga aggcctcagc tatcggggct ttattttctt tggcctcatg 9421 gttcaggata atcgctgtta ccttttggaa tacaatgtcc ggttgggaga tccggaaacc 9481 caggcggtgc tcccccttat gggaagcgac ctggcagaac tctgcctgag catagccggc 9541 ggaacccttc atcaatataa ccttacatgg aaaccgggct ttgtttgcgc ccccgtggca 9601 gtcgccgaag ggtaccccgg aacatatcgg aagggagatc ccatcagtat tgagagagat 9661 aaaattgcag ctgcgggagc ccaggtcttt attgccggtg caagcatgaa ccagaaagcc 9721 cttgatactg gcactcctga cagtggagac ggcgaaggga gtctgctccg tactacgggc 9781 ggccgagttt tagcagtctc agcctatgga acaaacctgg aagatgctcg aagccgggca 9841 taccagggga tggatggagt tcacttcacc ggtatggggt tcaggcggga tattggaacc 9901 tgttaggacg gccccaaagg cccctatcct cctcaagatt ataaagatgt aaaagaggtc 9961 ccatggatca aaccgcccag aataacctga gaaaaccgct ggataatctg attctgcaat 10021 tccgggtcca gggggctctc gatgataagg cgagatgcaa gaccatacag gcaggcccaa 10081 atcgtcatgg cggtaatttc gggcggtgcc ggggcaaatt cacccttttt catcccctct 10141 gacaatacag ctacgaataa agtaaaggtt ttgcgggact ggctaatacc ccgcttaagc 10201 ccattcacct gggatttccc aggccccgca tcctgcatca cgaccacctt aaacaggtcc 10261 ggttgctcta atgcaaaatt gatatacgca gaaatagcag caaccgtttt ttgaatacaa 10321 gaacgactgg aatcggttag gatctcctcc agggttttca gaagccggtc atagcccctc 10381 tggattattg tctgaacaag ctcgtccttg ttagaaaaat gccggtaaat tgcagcctcg 10441 ctgagaccta caagacgccc taattttcgc atagaaaacc ccggtagtcc ttgctgggct 10501 aacagctctt cacctgcttc aagcaatcgt tccctggttg ttttttatga gttcatacca 10561 ccatgttaac actgttaaca ctacttttca agcaaggtga caatggtttg tttctaccag 10621 ccaagtttat cagcttatat cggataaaaa aaggctgcca attaatgtgg aggcagccct 10681 gcacattctg tgcattacga gtattattct ttaacactac ccagattcat accgataaca 10741 aagtattttt gaataaaagg atacaccaca ataatcggtg ctgcggcaac aaccgtaatt 10801 gccgctcgaa tactcatggg ggttaccatg ttagactgtt gcgataaacc catggcacca 10861 atatcgccag caccacgaga ctgggcctgg ctcgactgta aaaactccat taatttatat 10921 tgtaatgtat gtaacttaac tttactcgat gcatagatga gtgtatcgaa ccaggaattc 10981 catgcaccca cagcaacaaa caatgctacc gtggcaagaa caggagtact taagggcaga 11041 ataattttaa agaaaatggt ataatcgctt cctccatcaa tccgaacaga ttcaataatg 11101 ctttcgggaa tacctcttaa aaaggtacga ataaccaaaa agttaaaggc actcaccatc 11161 gtagggataa catataccca aaaggagttc agtaatccca gattcttgat taaaaaatac 11221 gtcggaatta aaccagcatt gatatacata gatactacta gaataaccgt aaattgtctt 11281 ctaaaaataa agttcggtct tgaaagtaca taggcaatca tggacgtaaa gaaaacattg 11341 gtaaggacgt tgagaacggt acgtgcaaca gaaacaaaaa aggcacgaaa tatggcacct 11401 gtagaaaaaa ccattttata attttgcagc gtaaatcgtc ttggaaataa ggtaatgcct 11461 ccacggatag tatctaccgc ttcgttaaag gatacagcaa ccgtattcca aaaaggatag 11521 agcataatta cggaaaacag taccataatg gtaccattta ctgtattaaa aatataggat 11581 tcgtaattat atcgtttctt catatgagcc gttcctcacc caaacgtttt accagttcat 11641 ttgctaaaaa tatgagtgtc atattaacca cgttcttaaa aagccccgcc gctgtagcta 11701 atgaataatt cgatcgttgc aaaccaaaca tcaatacata aatatctata gtatctgaaa 11761 catcctgtac aagtccattt cgcagcaagt attgcatttc aaaacctgca tcgagaatat 11821 gtccaatact aagaataatg agaatgatta tcgttggttt gatgctggga agtgtgatat 11881 accacatttt tcgccatcga ccacagccat caatttctgc agcttcatac agcgtgggat 11941 cgacaccagc aatagcagca agatagataa tggtattcca tcctagctct ttccaaacat 12001 acgttgcacc tatgacaccc caaaagtatt ttggttctga gagccacagt accggttctt 12061 taataattcc caaaaattgc aatacattat ttacagctcc atcctctacc gacagcatcg 12121 tggccacaag tcctgtgacg ataacccagg ataaaaagtg cggaagataa gatatcgttt 12181 gtgttattcg tttaaaggca acatttttaa tttcattcaa taataaggca aaagaaatcg 12241 cggacacaaa ccctaatgtg gtattgataa tactcatcat aaaggtattt cgtatcgttc 12301 gtataaacac tggatcggaa aatagaaagc gaaaccattt cagtccaacc cattcctgtt 12361 gaaaaaaggt tttcgaggga cggaaatttt gaaatgccat ggtccagccc cataatggta 12421 catagctgaa caataaaaca taaagaatga tggggacaga cattactaag agatgtcttt 12481 gagtatatat cgtcgtaagt agtttgccac ccctcgtctg gcgtggtatc acattcatca 12541 taggcccctc gcacctgtaa aaattgagga gtgcgttaaa atcattcgat tttaacgcac 12601 ctcatcgaat tacgtatgaa ttacttcttt ttgctccaag cggctactcg ttttttcacc 12661 tgatcttcca tataagcttc ataaatcgaa ataccgttct tattcatctg atcgacatac 12721 tctgcccaca gtttttcaaa atctgcaggg ggtgcaagaa taatcttcgg caaatacttc 12781 cgcatggttt gatcacagcg ctgaagcgcg atctgagcgt cagacccatc aggtggattc 12841 ggtaaattcc aggtgggata ccaaatgggg tttggcggtg gattcttatc cattaactca 12901 gcatagctgg taacaccata ggcttgccaa agctctttat cttctggacg agtaatagct 12961 tcccgttcag gataataata tgtgaggtcc caaggataac catcattaaa cgaaccttcc 13021 cagttcggaa agatatccct aacaaggagt gctcgatttt gttcctgcca ggtgatattt 13081 tcccaattct tccgttgttc gggagtccgg tagggctcac ccttttcatt ccgttgccag 13141 tcttcgccct caatacccca ttgcatcatg cgctgaactt cttcactcaa gaggtcattg 13201 ataaactgga taattcgtac cgggtcttta gccttcttac tgataccaac accacggcca 13261 agattaggaa taggataatc tcggtagtga gggcggatag atgcatcaaa tacaactggt 13321 aatggagcaa aggtcctgtt gtacataccc gcatcccgga gagcatcatc ggcattctgg 13381 aactgccacc gctggtcatg catacctaag acccggccgg ttgcaagttt tgctaaatac 13441 tgatcatagt tgtctgagaa cgcagcctta tcaatatatc cttgagcatt cagttcattg 13501 agctttttga accatcgctt agagatatcc atggtaaaga acgttttata ctgtaaggta 13561 ttgggattaa ccacaccgtt gccatcgtta ggattgcccg caaggaaatt tggcgggttc 13621 cacaaacaga aggcatgcca atcgtaggtc agaatagtaa aggggattgt tttctgtcca 13681 ttgattgttg gatgtttttt agcatagtta atgagcagat caaagtactg atccatcgtg 13741 acaaccttag gatacccggc ttccttcagg acctccttct gaatccacat ggctgaggca 13801 ccataatagg gactctgatc cttgttatgg ataattcccc agttagtcag ataatagata 13861 tgaccatcgg gagatcgaag tttgtcccac tgatctccaa aatgggcttt aatattgggt 13921 ccgtattttt ctaccagatc ctcaagggga attaatgcac ccgcatcgat aaattgggtt 13981 tcattaattt ctattacatc aggataatct tcaccggcga tcataacgcc ccgtttctga 14041 gcaagctccc caacaaggat atcccattca aaagttacac ccagtttttc cttcagatac 14101 ttgtaagcct tattatccgg atttggctgt tgtctagatt gaatggtaaa aaccgatatg 14161 gttatcggtt ttcttgttgg aaccgcagat gcggattcat ttttctttgc acaccctgtg 14221 acaaaaagga atactactaa gcctagcatg agaccagtag ctcgaaccat gttcttcatg 14281 tacattcctc ctatgatttt atagtatatt acatgatatg gttcatattt tatgtttcat 14341 ataggtaaaa tgacctattt ttacaattat tggcgcctaa aaaaatgccc ggacacatga 14401 cgtagaccgg gcatcaaaat gaattgggag tccttatacg cctgcagcct gtatgaaggc 14461 atcttcactc aaaaattgct gggtatatag cttccagtac atgccatgta gggccataag 14521 ggactggtga tcaccatctt cgataattcg gcccttatcc atgaggataa tccggtccgc 14581 attcctgatc gtagaaagcc ggtgtgcaat gacaatactt gttcgtccgg caagcagccg 14641 gtttatggca ccctgtatca gaacttcagt ctcagtatcc accgaactgg ttgcctcatc 14701 gaggacaatg atccgaggat tggctaccag ggccctggca agacagataa gctgtttctg 14761 tcctactgag agcaaagcac ccccttctcc gacaggtgta tcaaagccct gttccagccg 14821 ttcgataaag gcataggcgt ttgcatcacg ggcagcctgt tcaatttcgt cgtccgttgc 14881 atccaaccgg ccataccgga tattttctct gaccgtgccg gaaaagagga gcggagtctg 14941 taccacatac cccagctgac tatgaagcca atgttgagtc cattcgcggt aatcccgtcc 15001 atcaatctgg atggaacctt cctccggttc atagaaccgg catatgagat tcaccagggt 15061 agatttacca cagccagttt cgccgaccac tgccacggtt tgccctgcgg gaatatacag 15121 ggaaaaattt ttaaatatcc atggcgcgtc ttttccatac cggaacgcta tgttttcgag 15181 cagcaattca ccacagatcg gaaccccttc acgagcattc ggccgatcca caatttccag 15241 ttctgtatcg ataagtccaa ccaaacgttc tgcacttgcc tgggctgctt gaaattctga 15301 aagcaccctg gcaacttccc gagctggatc aaagaacatt aacgcatagt tgatgaacgc 15361 tacgagggtc ccaaagctga ttatgccctt aaggagaaat tgtccgccag cccccagtgc 15421 gagagctgcg cccatagcag caagagatat gactatgggg aaaaaaagtg cagaaagtct 15481 tgcagctctg atagaatgat tccgtagggt ctgagttttt tctgcaaatt ccttatagtt 15541 gtacttctcg ataccgaggg ctttcgtagt cctgcctccc tgcaaccctt cattaaaggc 15601 tccggttact atagaatttg ccttacgagc ctttcgctgt gccatgagga tccgtttctg 15661 aaaccagaac gttatcacaa gaagtggagg aacaaatacg agggtaatcg ccgcgagaag 15721 cggttgcatc accaccataa atacgatgat ggtaagcatc atggtggttc cccatacgag 15781 gtctactatg ccccacgcaa tagtatctcc caatttttgg gcatccgagg tcattcgggc 15841 aatgatccag cctgccggag tacgatcata ataggaaaaa ctcaactgct gtaaacgctg 15901 gaaggccttt tcccgcaggg tatacacaag ccgtacctct atgatacctg cgatcatgat 15961 gagggcccac acattaaaac cctgcagcag cgctaagagc ccatatcgaa atataaaccg 16021 ggagattaat ggggccgaat ctggctcttg tgcaatcggg atgagtacat caagagcata 16081 tcgggtcatc tgcggaaata ttccatccaa tactgctacc cctatcatga taaggattaa 16141 aagaccaata acgggataga gtgctttccc gaactggaat atttttttcc agagagtcac 16201 atcaaattgg ctcgaatatt ctttttcttc aaattgtgtt tgttctgaca tgtatcttcc 16261 ttatttactc gtccataaac gcactttgta gttcagcaag ccggcgatat aatccaggct 16321 gctgtatcag atcttcatga ctgccctggg cggtaataca accatcttca agcaccagaa 16381 tcgtatctgc ctctgctagg gtcgtaagcc ggtgagcgac gataaaggtt gtcgtcgttc 16441 ccctgccttg tttccctatg gctcctcgta taagatgatc cgtttcgata tcgaccgcgc 16501 tcaggctgtc atccaaaatg aggataggag cggttctgag cagtgcccga gctaaggcaa 16561 ggcgctggcg ctggcctcct gaaagggtta ccccccgttc tccgaccatg gtctcataac 16621 catcctgaaa acccattgcg acatgatgaa aggcagcttt ctgtgcagca tcaatcaaag 16681 ttgcttcatt ggcgtcggga catgcggcca aaagattttc ccggaccgtt tttccaaata 16741 aaaagctgtc ctggagcacc agggatatgg ccttgcgaag ctccgctttg ggaatcgttc 16801 tgatgtcccg cccccctatc gttatatacc cctcgtttgg ttcataaaaa cgaactagaa 16861 gctgcattaa cgtggatttt ccactgcccg taggccccac aatagctaca tgttcccctg 16921 gaacaacccg aaaggaaata tgtttaagta cctcagtacc atcaggatag gaaaaggaca 16981 catcaacaaa ttcgatggga cctctagccc attcgtcatg aaaggagccc cctgcattgg 17041 agtatgatac cgcaggaacc cttatggtgc tatcaagatc tgtttctgtt acgagggtaa 17101 gtaattcagc aatacgacca agggcaacct tggtttttcc cgtatcggca agaatccgtc 17161 caaactgacg aaccggccag agtacctgct gttcataggt taagaaaagg accagcaggc 17221 caatcgtaat gaatcctgcg gtatagagct taagtccagc tcccagcagt aaggctattt 17281 gcagaagccc gagaaaactg gaaaaacccc aatagaaacc aagccaactg ataagcttgt 17341 atacctgatc tcgaagaccc ttgttggctc tgccaaaacg ctcaagttca tattgttgcc 17401 gtgcaaaggc ccgtaccacc cgaacaccgg taacattttc ctgaacaata cctgagagca 17461 ccccttcccg ttcatcagcc accaggaaga gccgctccac catcttctga aaataaaaag 17521 agaagagaat tattaccggc atcactatgc taccccagag ggtgagccga tagctcaggg 17581 aaaacataat gggaaacacg aaggctacta gagccagggt cctgaagagt tctacgaatt 17641 caaaggcaaa gaaacgccgg accgtatcca catcagaggt gcagcgctgg agccagtcac 17701 cagtctggga tctgagcatc gtctcatagg gtaaatgctg ggtatgatga tacagccgat 17761 cccgcaatgc ttttgcgctt tgctccgcgg cggtgttaac gctcagggaa gcgataaagc 17821 tgaaaaaggc ttgcataaaa atcatgcccg caaaggcaag accaagcacc cacagatggt 17881 ccctcagcca gggctgccat acccagggtg cgttccccca ggcctgaaga gtctgtaacg 17941 gcacgagttt ttcgagaaaa ccgcctcctt caaagttttt accgaggaat ggttccaata 18001 taacggacag agggaagcag atgatcggtg gcgcggtccc tataacacta tctatggtca 18061 attttactat cattggagaa gaaaaggtaa aaaatacttc cccgataatt gcagcgagac 18121 caagcgcata gatatgccgc cagcccttga ggacattcca taagagattg atgcgcccga 18181 aacggggcca cgagtttttt tggatactgt aaagttcttt tgttgtgaca gacac //