LOCUS NC_015680:5 18875 bp DNA linear BCT 31-AUG-2011 DEFINITION Pyrococcus yayanosii CH1 chromosome, complete genome. ACCESSION NC_015680 SOURCE Pyrococcus yayanosii CH1 chromosome, complete genome. COMMENT locus start: 691457; locus end: 710331 FEATURES Location/Qualifiers source 1..18875 /organism="Pyrococcus yayanosii CH1 chromosome, complete genome." gene complement(0..1118) /gene="" /locus_tag="" /db_xref="691457..692575" CDS complement(0..1118) /gene="" /locus_tag="" /product="hypothetical protein" /translation="VNGPGDVLRELLREKGIEAVGSLSKKWPSKGQVDIFQELALMIL EGEGAIVELPEETGIAWSLGGKRVAGSRFAFVRPCMFNHYPLVVSRENLLARLPEYPF IIIDLMLWDIHIPKEKGKVALQVRETYSVVRRYLWNRMLAVTWLNGEFERLASFPLNR VKAYSGPTADFLREKGIDEVVLLDPNAEKDLSPDDLSARAFIIGGIVDMKGDKKGTTA RIGEAIEEAGIRVRRRRISLRGDVVGVPDRINHIAEILLRMLVLGEDMERAILAVQSP LHARWRLRKEIPKRKIRFLVDGKLYLVVERELYDELSQWLNIRWEDFVKVLRETGIVA LERRRIHHLKKISLFKPDGKGGKWVLLLKRAALLCYNC" gene complement(1972..2526) /gene="" /locus_tag="" /db_xref="693429..693983" CDS complement(1972..2526) /gene="" /locus_tag="" /product="hypothetical protein" /translation="VEPKEAGPPRLVPLSILFESYWNSLPLLETVDDLVNFQFSLSLI GTHLILPPTPHIPALSILFESYWNPKNRAGEVVAVILSILFESYWNEEGLGVVEVKAE LSILFESYWNTIQELQKYSRKSLSILFESYWNRLLVIQKNSERSSFQFSLSLIGTPAG ADFPPARAPLSILFESYWNIGVMT" gene complement(3218..3421) /gene="" /locus_tag="" /db_xref="694675..694878" CDS complement(3218..3421) /gene="" /locus_tag="" /product="hypothetical protein" /translation="LSLIGTGFPAGSGPEPPKLSILFESYWNATKRALPAVRTSDFQF SLSLIGTEVEIIDIYEDDAFNSL" gene complement(4257..5741) /gene="" /locus_tag="" /db_xref="695714..697198" CDS complement(4257..5741) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MRVWITTVGTSPFAVFNSLWMAIARDSYYPDKIYLLWNDKVKRN MEKIKSYIEALAKAYGRTIAIDDTHKVDEEDFRTFTKTLAEIIKREKLEGNEIAIDMT PGRKFMSAFSMYAGIEGVEGGKFKADKIYYLHLRDLSYINLPLYLIPFSIQELLEMKS ELSGKERTKEPLRLEGEKEEIKITREELMAVINQEFLLGRELLKIKVSGKDIATISLR ENENLAKVSVVKNLSLPSYVGDYGLFSSVLNASGIRELKATLDGEKWMNEEELYRWLL NKIKEKETRYITFDTNSLIFGIPRRFLEFLDRQKDKAYSLNLAISRIVETELTKEKAK ILRDGRFFDEYVLDSDYWNQPSPKDRLFKLGQLQLKLLNERNAILIEPTREGTGDDVI LESFVEFLRKNEGELIVFTSDKNFFANLKHLRNIEPIYVGFGEIKEYVTWENVRDFIF ASAIVFGKVNVSGIGEVKAVWRGKNPWEWDKVKVSLKPETKKSH" gene complement(5738..6931) /gene="" /locus_tag="" /db_xref="697195..698388" CDS complement(5738..6931) /gene="" /locus_tag="" /product="CRISPR-associated protein" /translation="VKLLSFIGSSEYKETIYFYEDKTVRTEYIQEALTKIFQPSEVII FATKEAYKKHGEKLRERIENVQFVEIETPKTQEDIWSLFEKIVDSVDYNDEIILDITH AFRHIPFMSFPIILYLQEVKNVKIVGIYYGAFEAKTEKGAPIFDLSGILDLADWLYGV RDLKKYGRGEGIYNSIKNMNARFYKTNAPKKPKTLSGYADLILILLKNLQLNQIPEFM ELSAKAKKGYEEFKAEAIEFLPPIRYTLNEIERLTEFGCKEFGKESLEKQLGIIEYLL EKGMTANALELMREWIINAVIFLAGEKKWLSKDVRIKAEKTIGWFSAKIRGNTNGIEK TEWVEKLEKNEKIAKLAKVWLKVYEIRNAIAHAGMKEKKDRPKVNVIEKRSHEILKLL KEALP" gene 7297..8376 /gene="" /locus_tag="" /db_xref="698754..699833" CDS 7297..8376 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MYEATFELEAITPVFMRGAYQSKAEFRAPSIKGVMRWWFRALAG NYFGNDIAGLREAEGRIFGSAGSGGARRSRVGVVVESLSKPKNIFFKPPKVFDRESWV SDLPYLFFSIKMTAKSIRNSLFYPPGSVFRVSISSRDRSSYVASLASLWAAVVLGGFG FRSRRGAGSLWFKGRVKEFENIGLPTIIDSPKALRNGIKRAITLIGSAFGKEQEVILS PLSYPVLNEKTSYVALIEFDDPKNALRQFQRVYSGFRRKPGNKIHRIVFGLPIVKGNL GRIRWAAKKSRRASPMMVSVKPIETGYALVIVKFRTEPFYMVTRREERNTQEIINSVV DWSLLKEFDEKFQEKPAYGSLEVFQ" gene 8373..11255 /gene="" /locus_tag="" /db_xref="699830..702712" CDS 8373..11255 /gene="" /locus_tag="" /product="CRISPR-associated protein, Crm2 family" /translation="MRSEYLNALLEAYLEINPSEILSGQVPDEWKALSSFPLEGEPTK VVLKHPISSKEKELTETTHILAEGKTDIIKKIVSDFSLSAQSIEEFARFWNELPEKLQ EFYRGRIENLKKEGKLDASIDSDTLAQELVHFPADPLMPDHDWLSRLDIYATIKAAEK TGAKLYLLRFKISPVQGFIGNARTERDLWAGSHMLGYLTYQAISEIWHEYGPQAVIFP HLRGQPFFEFEIGLLEDKDELEIANIPNKVLAIIPVWEGESLEELKGRIESRIIRELK GIFNAAWDFYEINFEKKNIYEKTVEKYFTITIELIPFEEVKPVFGKLLKDYLTTLGQK ASMSTYYSELFTILDQLTDFRSREFEKVKQPEGFKCILCGEHVAIGGDVLEYSELRMK WEDLRKNLNSRGIYDIKSGERLCPLCLAKRFYPRFYALWKAEDVKSACDEQLGRKAKE YFEDKILNVKSFESVSEVAMKKLTRKAVKLWRESKLYVSDGSLKRPITWYDIFIDLLE PTRSEYGGAVLKPEGTSADSFLETLMKLRTAVLPLFKKLSPNIEVLYKENLRTLDSLA KIYGLNSNELMERGIDDEVRTNILEAIRNLEESIGEPPKYYALLKMDGDNMGKVISGT KAVKPLKEYSLTGDAPDVHRPITPTAHIAITRSLSKFAVEKVPKLSKEHHAELIYAGG DDVFALVPTDQAIPLAYELQKEFRKDWEGFDYLQGSTRSMSAGILAIYYKEPLYSAIR KVNELEHLAKESGRNALAIGYLTHSGNYYVVIVNWRIFGNDVVYDLLRSFTNERENMK EKISTRFLYEILNGVDKWPNEPDAIIQLLRYELMRHSNLSEEIIRKKLAEILWIARNV RIKLSREDLSSLKIENADAKTISSAIEEVIVDDPEKEEPSDTPDSIIQDTDKLENLWF NAITRKLEKKGISKDSARRISALVLKRQVKGAAILIKILREMGVGA" gene 11252..12322 /gene="" /locus_tag="" /db_xref="702709..703779" CDS 11252..12322 /gene="" /locus_tag="" /product="CRISPR-associated protein, Cmr3 family" /translation="LIVKITPNDVLFFRESRDFTAGDSHLAESLLPLPHTIAGALMAV MFVKGRYDLLNLELKEGKFRKPENWKPNFEIIGTFFMKKNELYFPVPKDIVSAKADGR SIITMAKLKEVQIGGQSFTTVFAEGESPLHFSPVSGFLSFEKLKSYLNGEYYSKNDLS EEITKNSSLYKWENRVGIGLNSSKTTVEGMFYRTRMLRLEKDTAIGIVLSKKNLDEVK KTLGKKGTLKLGGEGRFAHYEIIDEDPLEELEEISVKKNALFKLYLATPLIVDGQSWN IAEVLPEHINAKIVKVFMDRPEKITGWDLVKRRPKETLYAVPPGSVYILKAQEDLTLK PFYRLGMMVELGYGLVFAGKYG" gene 12382..12693 /gene="" /locus_tag="" /db_xref="703839..704150" CDS 12382..12693 /gene="" /locus_tag="" /product="CRISPR-associated protein, Csx3 family" /translation="LIKFRVKELGGFTVVHFELNEEIRPSILRNLNPPEVKGTKGVVL SGRGPIWLYGFLVHFYHYTRWVATYDPRLGGAVIIESHWPGVHPGDVVKLNLEEVLRN V" gene 12686..13591 /gene="" /locus_tag="" /db_xref="704143..705048" CDS 12686..13591 /gene="" /locus_tag="" /product="CRISPR-associated RAMP protein, Cmr4 family" /translation="MFEKILILGIYTTTPVHAGSGAEISVIDLPIQRERHTGFPVIWG QSLKGVLRSEFPGEDNDPTKTVIFGPPTDRAHEHAGAISVGDAKILLFPVRSAKGVFA YITCPLILERFKRDIELAGGSAGFKIQDVGEAEAIVSEDSSLVVSTGGEDKIVLEEVI LKVKKEDISPIVKAINNILPIPIDAKRIAIVSDDVFSSFVKMATEIVARIRIDARTGT VAEGGLWYEEFLPSDTVMYSMIAIANPRVKNPPKEVNSPKGIARKLIEVFNNRFLQIG GDETVGKGFVKVKLVEVNGNEPQKP" gene 13572..14042 /gene="" /locus_tag="" /db_xref="705029..705499" CDS 13572..14042 /gene="" /locus_tag="" /product="CRISPR-associated protein, Cmr5 family" /translation="MNLRSLEQERAAYAYECVKEVKEEDEKTQGRYAAYVKSAPVLIL TNGLGQTLAFYLAKIGKNIDEVDYKSIDPKSIEGGGDKKAYAYLYKHIARWLAEDIGC HKSLTNGTDPLKYIISQNSTSLDVMLLTEEALFLLNWLKRFADAMLKKDKDSGE" gene 14045..15079 /gene="" /locus_tag="" /db_xref="705502..706536" CDS 14045..15079 /gene="" /locus_tag="" /product="crispr-associated ramp protein, Cmr6 family" /translation="MANFRRSHKLSERNRHNDKKVKFIVPADTLKALEENPWRNISNV SLLLMKYVPYIFEKEKNNTYKAELKAPGISDEIIEAYSHYLAIYLEMLGGINTKAVLR LKSRLVVGLGDESVYETSIRLLRNYGVPYIPGSALKGIAKHYAFELLADVHWELLVEK FQNKFKRLKLERDVYGAIGFLQNAFEKDDNSLKKLKELNLAITLKDGTKTTVEELVDI FGTLNSEGKVVFFDALPSPVRDPPANLEQLRSSLKDIFKEDVLELDIMNPHYQPYYQE GKPPGDWYSPTPIFFLTVKKDTPFVFAVGPSKTCNDRKLVEKAWKLLKEALREHGVGA KTALGYGRFE" gene 15190..16203 /gene="" /locus_tag="" /db_xref="706647..707660" CDS 15190..16203 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MESLFLLVLGNTEISTVPGISVAGATPELTKLTPPADAEYIFYE KPKIIDAIPVTPEGHPTPAIITKAARELARFPIIVIRGGTYLAPKVPHVHISDVVGRD FRKEPALPEVEDIIETARLFGEELNKEPIEELVIGESTPGGTTTAQAVLWTLGYEAKT SSASPNNPQALKEQVIKAGFERAGIRFGELSDEPIEALRQFGDPMMATVIGISLGFRK KVVLAGGTQMLAVAALLKALGESLDRFMIATTKWVVNDRSATFIETAKEIGIMSYAAD LDFSRSEFKGLRDYEKGYVKEGVGAGGATWLAVKAGFSPEDVSRKVEELYKQLMNLKA ASP" gene 16277..17143 /gene="" /locus_tag="" /db_xref="707734..708600" CDS 16277..17143 /gene="" /locus_tag="" /product="cobalamin biosynthesis protein" /translation="MWDAITLLLAVLWDLSLGEPPTLIHPTVWFGRLIGFLDEHYRRR NPKVDFLAGTLSSLLVVAFALVLSTLPRFLPKLPSLVLPVYLLKSSFAIRSLAEHVKN TIKEDIEEQRHFVAMIVSRDVSGLDRAHLNSAAIESLAENTNDSVLAPLLYFLLFGLP GALVYRAVNTLDAMIGYRDERHEYFGKFAARLDDALNFIPARITVLLFLPLNPRKVLS HWRKARFKINSDKPIAAMSAVLGVWLEKEGVYRFEGREPTLEDVRRALKVYWIVVGEW ILTCLLLLTPGV" gene 17146..18117 /gene="" /locus_tag="" /db_xref="708603..709574" CDS 17146..18117 /gene="" /locus_tag="" /product="putative aminotransferase" /translation="MLRPIAFKAKHGGAREEGLLDFSASVNPYLPEWLDEMFERAKSL SGHYPYWERLEEELSVLIGKPATVTAGITEALYLLGPALGKKKIIIPKHTYEEYERVA RIFGARVVKGPNEPEKLAAFVEKESVVFFCNPNNPDGRFYRPKELRPLIDAVEDKGAL LVLDEAFIDFVKDAKSPEGENVIKLRTFTKSYGLPGIRVGYVLGFTEYFRSVRMPWSI GSLGLAFLEFVIKDGFEHLRKTMPLIWREKERLERALNVKSDANFFIKDVGDAKETVE TLKRRGILVRDCTSFGLPRHVRFGVRKPEENEKLIEAFRKLGLSQRF" gene 18131..18874 /gene="" /locus_tag="" /db_xref="709588..710331" CDS 18131..18874 /gene="" /locus_tag="" /product="SAM-dependent methyltransferase" /translation="VVACTNFILFYRSTTRRRAERVKDEINFVEGLFREDAEREVRRI LDLACGTGIPTLELARRGYHVTGLDLHEEMLTVARRKAEREELSVEFIQGNALEIDFE EEFDAITMFFSSIMYFDDSTIQVLFNSVKWALRPGGIFIADFPCWYYGGRDGPIVWDE RKGDERLILTDWRVVEPAFQKLHFKRLVQIVKPDGSVRAFMVDDELNIYTPREIRLLA EKHFRKVKIYGNLRELRPNDRRYWLVAVK" ORIGIN 1 tcagcagttg tagcagagga gggcggccct ctttaaaagt aaaacccact ttccgccctt 61 gccgtctggc ttgaagagcg atatcttctt gagatggtga atgcgccttc tctccaaggc 121 cacgatcccc gtctccctta aaaccttgac gaagtcctcc cacctgatgt tcagccactg 181 agagagctcg tcatagagct ccctctccac gactaggtag agctttccat caacgaggaa 241 gcgaatcttc ctctttggta tctccttcct gagcctccag cgggcgtgca ggggcgactg 301 aacggcaaga atggccctct ccatatcctc accgaggacg agcattctca ggagtatctc 361 ggctatgtgg tttatcctgt ccggaacacc cacgacatct cccctaaggc ttattctcct 421 tcgcctgacc cttatcccag cctcctcgat ggcctcgccg attctagctg tcgtaccctt 481 cttgtccccc ttcatgtcaa ctatgccacc tattatgaag gctctcgccg aaagatcatc 541 tggactcaag tctttctcgg cgttagggtc caggaggact acctcatcta ttcccttctc 601 ccttaggaag tcggccgtcg gaccggaata agccttcacc ctgttaagag gaaagcttgc 661 gagcctttcg aactctccgt tcaaccacgt taccgcaagc atcctgttcc agaggtagcg 721 cctcacaacc gagtaggtct ccctcacctg gagggcaacc tttcccttct ccttcgggat 781 gtggatgtcc caaagcatga gatcaatgat tatgaaggga tactccggaa gcctcgcgag 841 gagattttcc ctcgatacga cgaggggata gtggttaaac atgcacggcc taacgaaagc 901 gaacctagaa ccagctactc tctttccacc aaggctccac gcaatgccag tctcctcggg 961 caactcgact atagcacctt ccccctccag aatcatcaaa gcaagttcct ggaagatatc 1021 aacctgacct ttgctaggcc atttctttga taagctacca acagcctcga tgcccttttc 1081 cctcagcagc tccctaagaa catctccagg cccattcacc ggcatcgctt ggaaggagga 1141 aggcgggctt ttaagctttt aggctttggc agaaaaattt tcgattccag tcttcatact 1201 ttcttttttc attttactgg cttgtagtgg agtttttgac cgccagagct ctgaaatccc 1261 attggaagtc tttagtaatt ttttgttagt atatggcatt ttgttgtgtt ttctcgcgtg 1321 ttttgtaacg aaattttttt cggaatttgg agtggggcaa ggagggcact cctttcaccc 1381 caaaccctac tagaatcgta ttttttccaa atctctaaca taaaaagtct tgatttttga 1441 tttaattggt tgagaaaccg ttggaagcct tatgatcact ttcgatcatt gaaattatgg 1501 ggttttttag aagcttttta ccaaaagttt tgactcctca agactgcatt tcaagccctc 1561 tcaaggcctc gttaagaccc cctcgccaaa agatttataa aatccaagac tcccaagaaa 1621 agcatagaag aaaacaagca aaaaacccac ctgttccaat aagactcaaa gagaattgaa 1681 agaacttagt cggcgatagg tatgacatag ttaagaaagt tccaataaga ctcaaagaga 1741 attgaaagcg gggcctgatg cgggcgggat ccgccccgcc ggcctgttcc aataagactc 1801 aaagagaatt gaaagcaaac aactgcaccc acgaccgcgc caggagggcc ggctaaggtt 1861 ccaataagac tcaaagagaa ttgaaagttc taataatcac gagtacgacg tcttcgtcgt 1921 catgttccaa taagactcaa agagaattga aagtcgtttt cttcattatt atctatgtca 1981 ttacacctat gttccaataa gactcaaaga gaattgaaag cggggcgcga gccggcggga 2041 aatccgcccc cgcgggggtt ccaataagac tcaaagagaa ttgaaagctg gatctctctg 2101 aattcttctg gatcactagt aacctgttcc aataagactc aaagagaatt gaaagggatt 2161 ttctggagta cttttggagt tcctggatcg tgttccaata agactcaaag agaattgaaa 2221 gctctgcctt cacttccacc acccccaagc cttcttcgtt ccaataagac tcaaagagaa 2281 ttgaaaggat gacggcaaca acctcgcccg ccctgttctt cgggttccaa taagactcaa 2341 agagaattga aagtgctgga atgtggggcg tcggcggtag gatcaagtgg gttccaataa 2401 gactcaaaga gaattgaaag ttgacgagat catcgacggt ctcgagaagg gggaggctgt 2461 tccaataaga ctcaaagaga attgaaagcg gaaccaggcg aggagggcct gcttctttgg 2521 gctccacgcc gttccaataa gactcaaaga gaattgaaag ggggaggcga gaaggctagg 2581 tttcttcata gcatcaggtt ccaataagac tcaaagagaa ttgaaagccg ccctccctcg 2641 tcctcatctc aaccgcccca ctgcgttcca ataagactca aagagaattg aaagttgata 2701 atctctggat cctcgaagcc ggccttgagc agttccaata agactcaaag agaattgaaa 2761 gactctctcc caaagtaaca actgccagcg ctggtctctg ttccaataag actcaaagag 2821 aattgaaagc attcaaggga attggattta ctggcttgta gcgaagttcc aataagactc 2881 aaagagaatt gaaagctgta aagaaagttg acagtttctt gacctcttcc catgttccaa 2941 taagactcaa agagaattga aagccttttt agcagttcat ctgcgagccg aaacagagcc 3001 tgttccaata agactcaaag agaattgaaa gggcaaaaaa gcttggagaa gctaggcctt 3061 tacggactgg ttccaataag actcaaagag aattgaaagt atggatactg taggtacact 3121 cgatacgtca gcgcaagttc caataagact caaagagaat tgaaagggag ccccagagga 3181 gtgttccggg cccgggggag tccccgttcc aataagactc aaagagaatt gaaagcgtcg 3241 tcttcgtaga tgtctattat ctctacctcc gttccaataa gactcaaaga gaattgaaag 3301 tcacttgttc taactgctgg taaagctctt ttagttgcgt tccaataaga ctcaaagaga 3361 attgaaagtt tcgggggttc ggggcctgag ccggcgggga atccggttcc aataagactc 3421 aaagagaatt gaaagtgatg tagttagcga gatcctcctg gagtccattc ctagggttcc 3481 aataagactc aaagagaatt gaaaggaccc cggaatgcct acgaattcag ttaacaactc 3541 aagttccaat aagactcaaa gagaattgaa agggaaaggc ttccacgttg agttgccccg 3601 ctcgtccctg ttccaataag actctaagag aattgaaagt ttaccctaat tgcggccgtg 3661 atcattgcaa tcctctgatt gtttttgtta ttatttttgt tactcgttgg tttggttggg 3721 ttattatttt ggctatccgt ctgatcgatc atggtaatta cgagttctac ccgcggtgct 3781 aagtgggaga aaagcattcg tacgaacgca cgatacccat gcacttcacc cttgaagggc 3841 gggtgtggaa aatcgtgtcg agagttagga cgcgggccgg caaaattttc aagacccgca 3901 tgctgactaa tgtcataaca aaccagccta ggaattacta cttggattcg ttaaccgggg 3961 agtgttaaga tttcaccctc cctcacgatt tttttcttga atttttctag tgcgcgcaaa 4021 ataagaaaat aaaaaaatat actgcgttcc acttcaacac tttgcgtaaa aaactaacgc 4081 aaactatcag agcaatacta aaatggaaaa gaaaaagaaa aaaatatgta gctacgtcga 4141 gaacaagtaa ttttttgaaa acagacgaag ataagttaaa agtggacgtt aagtttttac 4201 tttttctttg aaagctgtgt catttacggt gaggcggagt tcagtgttcg gaggatttca 4261 atggcttttt tttgtctctg gtttaagtga gactttaacc ttgtcccact cccagggatt 4321 cttgcctctc cacactgcct taacttctcc aattccggaa acgtttactt ttccaaaaac 4381 aatggctgag gcgaatataa agtctctgac gttctcccac gttacatatt cctttatttc 4441 tccaaatccc acatagatgg gctcaatatt tctgaggtgt ttcaggtttg caaagaagtt 4501 cttgtctgaa gtgaagacta tcaattcgcc ttcgtttttc cttaaaaatt ctacaaagct 4561 ctcaaggata acatcatcgc ctgtaccttc tcttgttggt tcgatgagaa tggcgttcct 4621 ttcgttgagg agcttgagtt gtagttgtcc gagtttgaag agcctgtcct tgggtgatgg 4681 ctggttccag taatcgctat caagaacgta ctcgtcgaaa aatctgccat cccttagaat 4741 tttcgctttt tctttggtta attcggtttc aacgattctt gaaatggcaa ggttaaggga 4801 gtacgctttg tctttctgcc tgtcgaggaa ctcgagaaac cttcgtggaa taccgaaaat 4861 tagggaattt gtgtcaaatg ttatgtacct agtttccttt tccttgattt tgttcaaaag 4921 ccagcggtat agttcttctt cattcatcca cttctcaccg tcaagtgttg ccttgagctc 4981 tctgattcca gaagcgttca ggacactgct gaataatcca tagtcgccaa cgtagcttgg 5041 caggcttaag tttttaacta ctgaaacttt tgcgagattt tcattttctc tgagcgagat 5101 tgtggcaata tcttttccag aaactttaat cttgagtagt tctctgccga gtagaaactc 5161 ctggttgatt acagccataa gttcttctct cgttatcttt atctcctctt tttctccttc 5221 aagccttaag ggttcttttg ttctttcttt tccgctcagc tcgctcttca tttccaatag 5281 ctcttggata gagaagggga ttaggtagag ggggaggttt atgtagctta agtctctcag 5341 gtggaggtag taaatcttat cagctttaaa ctttccgcct tcaacgcctt cgattcctgc 5401 gtacattgaa aatgcgctca tgaactttct tcctggcgtc atgtctattg cgatttcgtt 5461 gccctcgagc ttttctctct ttattatttc tgccagtgtc tttgtgaatg ttctaaaatc 5521 ttcttcgtca accttgtgag tgtcgtcaat cgctattgtt cttccataag cctttgcaag 5581 cgcttcaatg taactcttaa ttttttccat gtttcttttc actttgtcgt tccagaggag 5641 gtaaatcttg tctgggtagt aggagtctct ggcgattgcc atccagagag agttgaatac 5701 ggcaaaggga gatgtaccaa cagtggtaat ccatactctc atggcaaagc ctcctttagt 5761 aatttgagta tttcatgaga tcttttctca ataacattca ctttgggtcg gtcttttttc 5821 tccttcatcc cagcgtgggc tatcgcattc ctgatttcgt aaactttgag ccaaaccttg 5881 gcaagtttag ctattttttc attcttttca agcttctcta cccattccgt tttttcaatt 5941 ccattcgtgt tccctctaat cttcgctgag aaccagccta ttgttttttc tgctttaatt 6001 ctaacatctt tgctcagcca cttcttttca ccagctaaga aaatcacagc gttgataatc 6061 cattccctca taagttctag ggcatttgcc gtcatgcctt tttcaagtag gtattcaatt 6121 attccgagtt gcttttctaa actttccttg ccaaattcct tgcacccgaa ttcagttagg 6181 cgttcaatct cgttaagcgt gtaccttatc ggtggaagga attcaattgc ctcagctttg 6241 aactcttcat aacctttctt ggcttttgct gatagttcca tgaattctgg aatttgattt 6301 agctggaggt tcttgagtag gataaggatt agatcagcat agcccgacaa agtttttggt 6361 ttctttggag cgttggtttt gtaaaacctt gcgttcatgt ttttgattga attgtaaatg 6421 ccctcccctc tgccatactt tttcagatct ctcactccat agagccaatc agctaagtcg 6481 aggattccac tgaggtcaaa gattggtgca cctttttcag tctttgcctc aaaggctcca 6541 tagtagattc ccacaatctt gacgtttttg acctcttgga ggtaaagtat gatggggaat 6601 gacatgaagg gtatgtgtct gaaggcgtga gttatgtcga gaattatttc atcattgtaa 6661 tcaacgctgt caacgatttt ctcaaacagg ctccagatgt cttcttgagt ttttggcgtt 6721 tctatctcaa cgaattgaac gttttctatt ctctctctta gcttttcccc atgctttttg 6781 taagcttctt ttgtcgcgaa gattatgacc tcggagggct gaaatatttt tgtcaatgct 6841 tcttgaatgt attctgtcct cacagtttta tcctcataga aatatatagt ttctttgtat 6901 tcgctagatc cgataaagct caacaacttc actacacacc accatgtatt gtaatatcct 6961 tccgggactt aaagttttct tttgcaaaga ggtgcttttt tgaaggataa tggcatgacc 7021 cacaccgcaa aataacattt cagaaactca tagttgaatg tagggtttcc ttataaaagg 7081 cttcttttag tatatgagca tgcgaaatat ttttatcaac aactttgcat agacaatact 7141 agggatccgc gatgaagtat cttatcgtca tgactcagga tggtgaattg gagagtaatt 7201 ccttgatttt cctggagaac taattaaaag cgactctaaa ctcgctgagc tcatgaggag 7261 attgaataat gtcgaaaacg ttttgtgagg tgttggtatg tatgaggcaa catttgagct 7321 tgaagcaata acgcctgttt tcatgagggg agcttatcaa agcaaagccg aattcagggc 7381 accatcaatc aaaggtgtga tgaggtggtg gttcagggct ctggctggaa actactttgg 7441 aaacgacatt gccgggctta gggaggctga agggagaatc ttcggctctg caggtagtgg 7501 aggggcaagg aggagcagag ttggggtagt tgtggaatcc ctctcgaagc ccaaaaatat 7561 ctttttcaag ccccccaagg tctttgacag ggagtcgtgg gtgagcgacc ttccgtatct 7621 ttttttctcc ataaaaatga cagctaagag catacggaat tccctgttct acccgcccgg 7681 ttcagtcttt agggtctcca tctcctcacg agatcgttcc tcttatgtgg cctccctagc 7741 ttccctatgg gcggcagttg tcctcggggg ttttggcttt cgctcaagga gaggtgcggg 7801 aagtctctgg ttcaagggca gggtgaagga gttcgagaat atcggacttc caaccatcat 7861 tgactcgcca aaagctctca gaaatggaat aaaacgagcc ataactctca taggctcagc 7921 tttcggaaag gaacaggagg taatacttag tcctctcagc tatcctgttc tcaatgaaaa 7981 aacaagttat gttgccctga ttgagtttga tgatccgaaa aatgccctaa ggcagtttca 8041 aagggtttac tcgggcttca gaagaaagcc cgggaacaag attcacagga ttgtcttcgg 8101 tcttccgatc gtcaaaggca accttggaag gattaggtgg gccgccaaga agtcgaggag 8161 ggcatctccc atgatggtca gcgttaagcc aatcgaaacc ggatatgcat tagtgatagt 8221 gaagttccga acggagccat tctacatggt caccaggcgg gaggaaagga acactcaaga 8281 aattataaac agtgttgtgg actggagcct cttgaaagag tttgatgaga aatttcagga 8341 gaaacccgct tacggctcac tggaggtgtt ccaatgaggt ccgagtacct taatgctctt 8401 cttgaggcat atcttgaaat caacccctca gagatactct ccggacaagt gccggatgaa 8461 tggaaagctc tctcaagctt tccccttgag ggtgagccaa cgaaggtagt gctcaaacac 8521 cccataagct cgaaagagaa ggagttgact gaaaccaccc acatccttgc cgaaggaaaa 8581 acggacataa tcaagaaaat agtgagtgac tttagtcttt cagctcaaag cattgaggag 8641 tttgccaggt tctggaatga acttcctgag aaactccagg aattttacag aggtaggatt 8701 gagaacctaa agaaggaagg aaaactcgat gccagcattg attccgacac ccttgcccaa 8761 gagcttgttc acttccccgc tgatcccctt atgccagacc acgactggct gagcaggctc 8821 gacatctatg caaccataaa agctgctgaa aagacgggag caaagctgta tcttctccgc 8881 tttaaaatat ccccagttca gggattcata ggcaacgcaa gaacggaaag agatctctgg 8941 gctggaagcc acatgctggg ctacttgacg tatcaggcaa tcagcgaaat atggcatgaa 9001 tacggtcctc aggctgtaat atttcctcat ctccgtggtc agccattctt tgagtttgaa 9061 attgggctgt tggaggacaa ggatgagctg gagatagcca acatacccaa taaggtgctt 9121 gccattatcc cggtctggga aggagaaagt cttgaagagc ttaagggaag aattgagagt 9181 agaataatcc gggagctcaa aggtattttt aatgcagcat gggatttcta tgagatcaac 9241 ttcgaaaaga aaaatatcta cgaaaagaca gtagagaaat acttcacaat tacaattgaa 9301 ctgattccgt ttgaggaagt aaaaccagtc tttggaaagc tccttaagga ttatctaacg 9361 acattagggc aaaaagcctc catgagcacc tattactctg agctattcac gatactcgac 9421 cagctgaccg acttccgctc aagagaattt gaaaaagtaa agcaaccgga agggttcaag 9481 tgcatcctct gcggagaaca cgttgcaata ggcggagatg ttctcgagta ttccgaactt 9541 aggatgaaat gggaagattt gagaaaaaat ctgaattcaa gaggcatcta tgatattaaa 9601 tccggggaac gcctttgtcc gctttgtctg gcaaagcgct tctatccaag attttatgcc 9661 ttgtggaagg cagaagatgt aaaaagcgct tgcgacgagc agttggggag aaaagccaaa 9721 gaatactttg aagataaaat tttgaacgtc aagagctttg aatccgtgag tgaggttgct 9781 atgaaaaaac ttacgaggaa agccgttaag ctgtggaggg aaagcaagct ttatgtaagt 9841 gacggctctt taaaacgtcc catcacatgg tatgatatct tcatagatct tcttgaaccc 9901 acccgttccg aatacggcgg agccgtttta aaacctgaag ggacgtctgc agattccttc 9961 ctagaaaccc ttatgaagct tagaaccgca gttctccctc tattcaagaa actttcgcca 10021 aacatcgaag ttctctacaa agaaaacttg agaaccttgg attccctagc aaagatttac 10081 gggctgaact ccaatgagct gatggagagg ggcatagatg acgaggtaag aacaaatatc 10141 ctagaggcaa tccggaatct tgaagagtca attggtgaac ctccgaaata ttatgcactc 10201 ctaaagatgg atggcgataa tatgggcaag gttatcagcg ggactaaagc tgtaaaaccg 10261 ctaaaggaat actcactcac cggagacgct ccggatgttc acagaccaat aactccaacc 10321 gcccacatag ccataacccg ctcactctca aagtttgccg ttgagaaagt tcccaagcta 10381 tctaaggaac atcatgctga gcttatttat gcaggaggag atgatgtttt tgccctcgta 10441 ccaactgacc aagccattcc gcttgcatac gagcttcaaa aagaattcag aaaagactgg 10501 gaaggatttg attacctcca gggaagcacg agaagcatga gtgccggaat cttggcaatt 10561 tattacaagg agcctcttta cagtgctatt aggaaggtca atgagcttga gcacttggca 10621 aaggagagcg gaagaaatgc cttggcaata ggctacctca cacacagcgg aaactactat 10681 gtggtaatcg tgaactggag gattttcggt aatgatgtag tttatgacct attgaggtca 10741 tttactaatg aaagagaaaa catgaaggaa aagataagca ctcgcttcct ttatgagatt 10801 ctcaacggtg ttgataaatg gcccaatgaa cccgatgcca tcattcagct tctccgctat 10861 gagctaatga gacattcaaa cctttcggag gaaatcatca ggaaaaaact tgctgaaatc 10921 ctgtggattg caaggaacgt taggatcaag ttgagcagag aagatttaag ctcgttgaaa 10981 attgaaaatg ccgatgcaaa aacgataagc tctgctatcg aggaagtaat agttgatgat 11041 ccagaaaagg aagaaccatc agatacccct gacagcataa tccaagacac tgacaagctg 11101 gagaatctgt ggtttaatgc catcacaaga aaactcgaga aaaagggaat ttccaaggat 11161 tccgcaagaa gaataagtgc ccttgtgctt aagaggcagg ttaaaggagc ggcaattctt 11221 atcaaaatac ttcgtgaaat gggggtggga gcttgatcgt gaaaataacc cccaacgatg 11281 tgttgttctt cagagagagc agagacttta ccgctggaga tagccacctc gcggaatctc 11341 tcctccctct cccacacaca attgccggtg cattaatggc ggtaatgttc gtcaagggac 11401 gctatgactt actgaacctg gagctcaagg agggaaagtt cagaaagcca gagaattgga 11461 agccaaattt tgaaatcatc ggaacatttt ttatgaagaa aaatgagctc tacttccccg 11521 ttccaaagga catcgtgagt gcgaaagcag acggaaggag catcatcacc atggcaaagc 11581 ttaaggaagt gcagattgga gggcaaagct ttacaacagt tttcgctgaa ggtgaaagtc 11641 ctctccactt ctctccagtt agtggattcc taagctttga aaaactcaag agctatctaa 11701 acggtgaata ttacagcaaa aatgatctct ccgaggaaat aaccaaaaac agctcacttt 11761 acaaatggga aaacagggta ggtataggcc taaactcctc aaaaaccact gtcgaaggaa 11821 tgttctacag aacaaggatg ctcaggctgg aaaaagacac ggcaattggg atagttctta 11881 gcaagaaaaa tcttgatgaa gtaaagaaga cgctcggtaa gaagggtact ctgaagctcg 11941 gcggagaggg aagatttgcc cactatgaga ttatagatga agatcccttg gaggagctcg 12001 aagagatcag cgttaaaaag aatgccctat tcaagctcta ccttgcaact cccctaatcg 12061 tagatggaca gagctggaac atagcagaag ttctgccaga acacatcaac gccaaaattg 12121 ttaaggtctt catggacaga ccagaaaaga taaccggctg ggacttggtt aagagacgtc 12181 ccaaagagac cctctacgca gttccaccag gcagtgttta catccttaaa gcccaggaag 12241 atttgacgtt aaaacctttc taccggcttg gaatgatggt agaattaggc tatggacttg 12301 tttttgcagg taaatacggc tgaggtggtg ataatgggca tttatcactt atctaaccta 12361 agttccccgg aggtggcaag ctttgattaa gttcagagtt aaggagcttg gaggcttcac 12421 tgtcgtgcat tttgagctta acgaagaaat tagaccatca attttaagga acctcaatcc 12481 accagaggtt aaaggcacga aaggcgttgt gttaagcggt agaggaccga tatggctcta 12541 cggctttctt gttcattttt accactatac ccgctgggtg gccacttacg acccccgcct 12601 cggcggggcc gtaatcattg agtctcactg gcccggagtt cacccaggtg atgttgttaa 12661 gctaaatctt gaggaggtgc ttagaaatgt ttgaaaaaat ccttattttg ggaatataca 12721 ccacaacgcc cgtacatgct gggagcggag ctgagataag cgtaattgac ctgccaatac 12781 agagagaaag gcacacgggc tttcccgtga tatggggaca gagcctgaaa ggagttctca 12841 gaagcgagtt tccaggagaa gataacgacc caacgaaaac cgttattttt ggtcccccaa 12901 ccgatagagc ccacgaacac gccggtgcaa taagtgtcgg agatgcaaaa atcctgctct 12961 tcccggtaag gagtgccaaa ggagtctttg cctacatcac atgtcctctc atcttggaga 13021 gattcaagag agacatagag cttgcaggag ggagtgctgg ctttaaaata caggatgttg 13081 gagaagcgga agcaatagta agtgaggatt cttcacttgt tgtcagcaca ggcggtgagg 13141 ataaaatcgt ccttgaagag gtcattctaa aggtgaagaa agaagacatc agtccaatag 13201 tcaaggcaat taacaacatt ttgccaattc caatagacgc aaaaagaatt gcaatagtga 13261 gcgacgacgt gttttcatct ttcgtgaaaa tggcaacaga gattgtggca aggataagga 13321 ttgacgccag gacgggaaca gttgccgaag gtggcctctg gtatgaggag ttcctcccaa 13381 gcgacacagt aatgtactcc atgatagcta ttgcaaaccc aagggtcaaa aacccaccaa 13441 aagaagtcaa ctcccctaag ggaatagctc gcaagctgat tgaagttttt aacaataggt 13501 ttctccaaat aggcggcgat gagactgtag gaaagggctt cgttaaggtc aagctggtag 13561 aggtgaacgg caatgaacct cagaagcctt gagcaggagc gagcagccta cgcttacgag 13621 tgtgtgaaag aggttaagga ggaggacgag aagacccaag gaagatacgc agcctacgtc 13681 aagagcgccc cagtcctcat actgacaaac ggactcgggc aaacgctggc gttctacttg 13741 gccaagatag gtaagaacat tgacgaagtg gactacaagt caatagaccc caaaagcatc 13801 gagggaggtg gtgataaaaa ggcatacgcc tacctttaca agcacatcgc aagatggctt 13861 gccgaggaca tagggtgcca caaaagtcta acaaacggta ccgatcccct aaaatacata 13921 attagccaga actcaaccag tctcgacgtg atgcttctaa ccgaagaagc acttttcctt 13981 ctcaactggc tgaagcgctt tgccgatgca atgctgaaga aagacaagga tagcggtgag 14041 tgaacatggc caacttcagg agaagtcata agctctcaga aaggaatcgt cacaacgata 14101 aaaaagttaa attcatagtt cccgcagaca cactcaaagc acttgaagag aacccatgga 14161 gaaatatcag caacgttagc cttctactga tgaagtacgt accctacata tttgagaaag 14221 agaaaaataa tacatacaaa gcagagctca aagctccagg aatttccgat gaaattattg 14281 aggcatattc ccactactta gccatatacc tcgaaatgct tgggggtatt aacacgaaag 14341 cagtgctacg cctaaagtcg agacttgtag ttggtctggg cgacgaaagc gtttacgaaa 14401 ccagcataag gctactcagg aactatgggg ttccttacat tccgggatca gcgctaaagg 14461 gtattgctaa gcactatgcc ttcgaactcc ttgcggatgt ccactgggag cttcttgttg 14521 agaagttcca gaataaattc aagaggctga agctagagag ggacgtttat ggagccatag 14581 gctttctcca gaatgccttt gagaaggatg ataatagttt gaagaagctc aaggagctca 14641 accttgcgat aacactaaag gacggcacaa aaacaaccgt tgaggagctg gtggatatct 14701 tcggaacact taacagtgag gggaaggtcg ttttctttga cgccctgccg tcccctgtga 14761 gagatcctcc cgcaaattta gaacagctca gatcctccct caaagatatt tttaaggagg 14821 atgttcttga gcttgacata atgaacccgc actatcaacc gtactatcag gaaggaaaac 14881 cgccaggcga ctggtacagc ccgaccccaa tatttttcct cacagtgaaa aaagatactc 14941 cattcgtctt tgcagttgga ccatccaaga cctgcaatga cagaaagctt gtggagaaag 15001 catggaaact tctcaaggaa gcgttaagag agcacggcgt gggagcgaag actgcgctcg 15061 gctatgggag atttgaatag ttttttcaaa attttctttt atagtcaatt tatttatcct 15121 ctccagcttc tcccctcacc ccaccaaagc gcatataaat ctttggataa aaactccagc 15181 ggtgattaga atggagagtc tcttcctact cgtcctaggc aacaccgaga taagcaccgt 15241 gccaggaata agcgtcgctg gagcaacgcc agagctaacg aaacttaccc caccagccga 15301 tgcagagtac atcttctacg agaagcccaa gataatagac gccattccag taacaccaga 15361 gggtcatccg acgccagcca taataacgaa agccgctagg gagctggcaa gattccccat 15421 tatagtgatc agaggcggga catacttagc cccaaaggtt ccccatgttc acataagcga 15481 tgtcgtcggc agagacttca gaaaggagcc ggcccttccg gaggttgaag acataatcga 15541 gacggcaaga cttttcggcg aagaattaaa caaagagcca atcgaggagc ttgtcatagg 15601 cgaatcaacg ccaggtggaa cgacaaccgc ccaagctgtc ctgtggaccc tcggctatga 15661 ggccaaaacc tcctctgctt caccgaacaa cccgcaggcc cttaaagagc aggtcataaa 15721 ggccggcttc gagagggccg gaataaggtt tggcgaactt agcgatgaac ccattgaggc 15781 tctcaggcag tttggcgatc ctatgatggc aaccgtgatt gggatatcac ttggcttcag 15841 aaaaaaggtc gtcctcgccg gcgggactca gatgctggcc gtcgccgccc tcctcaaagc 15901 ccttggtgaa agccttgaca ggttcatgat agctaccacg aagtgggtcg tcaacgacag 15961 gagtgccacc ttcatcgaga cggcgaagga gatagggata atgagctacg ctgccgacct 16021 tgacttctcg aggagtgaat tcaagggcct tagagattac gagaaaggct acgttaagga 16081 aggcgttggg gctggagggg caacgtggct ggcagttaaa gccggatttt cgcccgagga 16141 tgtgagcagg aaagttgagg agctctacaa gcaactcatg aaccttaagg ccgcttctcc 16201 ttaatggatt ttcacaattt tttaattttc cacacctcga aagcccagcg accgtcaagg 16261 ataaagaggg caggccaatg tgggacgcca taactctcct gctcgctgtc ctctgggacc 16321 tatccctcgg cgagcccccc acgttgatcc accccaccgt ctggtttgga aggttaattg 16381 gattccttga cgagcactat aggcgaagaa atccaaaagt tgatttcctc gctggcaccc 16441 tttcgtccct tctcgtcgtc gcatttgcct tggtcctttc taccctccca agatttcttc 16501 caaaattgcc cagccttgtc ctgccggtct atcttctgaa gagctccttc gccataagga 16561 gtcttgccga gcacgtgaag aacacgataa aggaagacat cgaagaacag aggcatttcg 16621 tcgccatgat agtcagcaga gatgtctcgg ggctcgacag ggcccaccta aactcagccg 16681 cgatagagag ccttgccgag aacaccaacg acagcgtgtt agctccgctg ctatacttcc 16741 tgctatttgg cctccccggg gcgctcgttt accgggcggt gaacacgctc gacgcaatga 16801 taggctatag ggacgagagg cacgagtact tcggcaagtt tgcggcgagg cttgacgacg 16861 ccctcaactt cataccggct cggattacgg tgctcctctt cctgcccctc aaccctagga 16921 aggtgctctc ccactggcga aaagccaggt tcaagataaa ctcagacaag cctatagcgg 16981 ccatgagtgc agttctcggt gtctggcttg agaaagaagg ggtttatcgg tttgaaggca 17041 gagaaccaac gctggaggac gtaaggaggg cgctgaaggt ttactggatt gtggtgggag 17101 agtggatttt aacatgtcta cttctactca cccctggggt gtgatcatgc taaggccaat 17161 agcctttaaa gccaagcacg gcggcgctag ggaagaaggt ttgctcgact tctcagcctc 17221 cgtaaacccg tatctgcccg agtggctcga cgagatgttt gaacgggcca agagtctaag 17281 cggccactat ccttactggg aacgcctgga agaggagctt tcggtcttaa taggtaagcc 17341 cgcaacggtg acggcgggca taaccgaggc cctctacctc ctcggacctg cactgggaaa 17401 gaaaaaaatc ataatcccaa agcacaccta cgaggagtac gagcgcgtcg ccagaatttt 17461 cggtgcaagg gtcgtgaagg gccccaacga gcccgagaag ctggccgcat ttgtggaaaa 17521 ggaaagtgtc gtcttcttct gcaaccccaa caaccccgac ggaagattct accggccaaa 17581 ggagctaaga cccctcatcg acgccgtcga ggataaaggg gctcttctcg tcctcgatga 17641 ggccttcata gacttcgtga aagacgctaa aagtccggaa ggtgagaacg tcataaagct 17701 aaggacgttc accaagagtt atggccttcc cgggataagg gtgggctacg ttctcggctt 17761 caccgagtac ttcaggagcg tccggatgcc atggagcata ggttcccttg gcctggcctt 17821 ccttgagttc gtaatcaagg acggcttcga gcatctgagg aagacgatgc ccctaatctg 17881 gcgggagaag gaaaggcttg agagggcttt aaacgtcaag agcgacgcga acttcttcat 17941 aaaggacgta ggtgacgcca aagaaaccgt cgagaccctt aagcgcaggg gaatcctcgt 18001 gagggactgc acgagctttg gactacctcg gcacgtgcgg ttcggcgtca gaaagccaga 18061 ggaaaacgag aagcttatcg aagcttttcg aaagcttggg ctctcgcaac ggttttaagg 18121 tgaactaccc ggtggtagca tgcacgaact ttatactatt ttatcggagt actacgcgga 18181 gaagggccga gcgcgttaag gacgagataa acttcgtgga gggactcttt agagaggatg 18241 cggaaaggga agtacggcga atcctagacc ttgcctgtgg aaccggaatt ccaacgctcg 18301 aactcgcgag gaggggatac catgttacag gcctcgacct ccacgaagag atgctgaccg 18361 tcgcgagaag aaaggccgaa agggaagagc ttagcgtcga gttcattcag ggaaacgcgc 18421 ttgagataga ttttgaggaa gagttcgacg cgataacgat gtttttctct tcaatcatgt 18481 atttcgatga ttctacaatt caggtattat ttaattctgt aaaatgggct ctcaggccgg 18541 gcgggatttt catcgccgac ttcccgtgct ggtactacgg cggaagggac ggcccgatag 18601 tatgggacga gcggaagggc gatgagcggt taatcctaac cgactggcga gttgttgaac 18661 ccgccttcca gaaactccac ttcaagaggc tcgtgcagat agtgaagccc gacgggagcg 18721 ttagggcctt catggtggac gatgagctca acatctacac cccaagggag attaggcttt 18781 tggccgagaa gcacttcagg aaggtcaaaa tctacggaaa cctgcgcgag ctgaggccca 18841 acgacagaag gtactggctg gtggcagtga agtag //