LOCUS NC_013316:13 19062 bp DNA linear BCT 27-AUG-2011 DEFINITION Clostridium difficile R20291, complete genome. ACCESSION NC_013316 SOURCE Clostridium difficile R20291, complete genome. COMMENT locus start: 2623199; locus end: 2642260 FEATURES Location/Qualifiers source 1..19062 /organism="Clostridium difficile R20291, complete genome." gene complement(0..1403) /gene="" /locus_tag="" /db_xref="2623199..2624602" CDS complement(0..1403) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKGSDLVKFELMDFLMNPFVLMFAAVITGILFGKIKFGKFNFGV SGALFTGLFIGWLAYSLGNLIIAKGETAAGYKAATVMMGNGIISSDFFDFFLIIFVAA VGLLAAKDMKAVLKKYGARFVILGVLITFIGGSMTYAMTLLSSDKGSSAYEVSGVYTG ALTSSPGLAAALETAGKHAEDVSKEFEKASIKDKKEILKVVDPEGKLDVNTTTSLTQE QIDKYIAYAEAGVGIGHAVAYPFGVLIVILGVNFLPKLFRMDLKEERRKYEKEMKEAR DSVSGKTIPEVPFNIITFFLTCLAGYLVGGIHVFMGPLGYFTLGATGGSLIVSLVLGY IGKIGVVNFRMEEKVLNILKQIGLVFFLAIVGLRYGGKVVDSIMTSGMHLALVAIAVG VTAMMIGFLVGKYVFKLNWILLSGAVCGGMTSTPGLGAAVDALDSDDPAAGYGATYPF ALLTKVILVIVLHKLPM" gene 1820..2692 /gene="" /locus_tag="" /db_xref="2625019..2625891" CDS 1820..2692 /gene="" /locus_tag="" /product="LysR-family regulatory protein" /translation="MNINYLYYFQTVCKYKNMTKAAESIHISQPSITLAIKELEKELG FELFYRIGNKIELTPEGKIFLDKSKHFIKQFEDFQCDALDLGKKRKASLKIGIPTVLG TFLLSKILPRFNVIYPDIELKIFEVPTFVGAKMIEESTLDFCIGIIDSDIYDDIDSKT IYKTELYLVTNPKNELAKHPIISNYMLKNVPFVILSEGSYHYKIITKRLEKAKPNIIL HSNQLSTIRYLLENDLASTILYKEIFQNTENLCSIPLERAITANIGVLWRRNQYISHS MKLFIEYMASIHIN" gene complement(2879..3478) /gene="" /locus_tag="" /db_xref="2626078..2626677" CDS complement(2879..3478) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MYKKHKFIKNIKKAWYKIKLIDRCLIIVMAILMFQSIYNLFVNE VNSQDTTTIDVVVRTTSAAIFGYFLSANFIKRPLRKYTNTDVSSNLFIDNNLPPKGQE SSQNNIMNVKNTIGFTSEADNYEKKIPINNNEGFEEGETSELQIIIATVICIAALTVL FVVRNFTTTTSASLGTISQMRDFVSGCVGFLLGCPSKPD" gene complement(3591..4670) /gene="" /locus_tag="" /db_xref="2626790..2627869" CDS complement(3591..4670) /gene="" /locus_tag="" /product="putative Xaa-Pro dipeptidase" /translation="MSRVKNVVGLLGTKGVDALYLTKKTNVNYISGFPDEEAYAVICK DGNFLVTDSRYMELAEKVCKDFEIINWHNFDRSVAKAVKSVCDKVGIKKLGFERTNIV FDKYEELKNLIEKDNGELIPTENIVETLRYVKDKDEIKNTRKACEIADKALEELIPHI KAGVSEIELATKLEYFMKMNGAQNIGFETILISGAKTSLLHGKPSDKIIEKGDFVLID YGAMYNGYISDTTRTFIVGGASEKQLEIYNLVKEAQNVGVENMKAGVHATIPDAEIRK VVKKYEDYYYQGIGHGVGRDVHEEPFIGNYGDKIIEEGCIITMEPGIYFPGWGGVRIE DTVLITKNGPERLTKFPKDLMILDK" gene complement(4980..6125) /gene="grdD" /locus_tag="grdD" /db_xref="2628179..2629324" CDS complement(4980..6125) /gene="grdD" /locus_tag="grdD" /product="glycine/sarcosine/betaine reductase complex component C alpha subunit" /translation="MSKKVIADVFLEVANAIESGEFGKKVKIGVTTLGSEHGVENMVN GAQLAKSNLFDIVLIGPKVETDLEVVEVNDEKEMHAKMEELLDSGYIDACVTMHYNFP IGVSTVGRVITPAKGKEMILATTTGTSATNRIEAMVRNAIYGIATAKSMGNKCPKVGI LNVDGARQVEKCLKELKDNGYDMEFADSIRADGGCVMRGNDLLVGAPDVMVTDTLSGN IFMKVFSSYTTGGDYEAQGFGYGPGVGEDYDRKVLIVSRASGSPVVANALKYAYDVVK GDISNVARNEFAKVKKAKFDDIISSLTKKEVKAEKVEVKMPDKEIVTRQIAGVDIMDL EDAVSELWKNGIYAESGMGCTGPIVLVNEAKGDLAVETLVKAGYTAK" gene complement(6136..7683) /gene="grdC" /locus_tag="grdC" /db_xref="2629335..2630882" CDS complement(6136..7683) /gene="grdC" /locus_tag="grdC" /product="glycine/sarcosine/betaine reductase complex component C beta subunit" /translation="MEVHKMTYPVLKGAGYVLIHTPDMIVQNGSTCTVERATNSDSEF LKEVSNHIRSYEDVVNYMPNQVYIGNRRPEELRDLPMPWCEQKIEGTRNGKFGEIMPQ DEFIALMQISDAFDLVKLSQEFIDEVKPKIENNYPEIAPFVGKLKGDDIEEGKELVAT HIAEGLYHDGKFVGYVKRAHDVDVNLNAHTMFENLVVKASGVLSAIQMLRHSKIDPAE IDYVIECSEEACGDINQRGGGNFAKSIAEIAGLQNATGSDTRGFCAAPTHALIQAAAL VKAGIHKNVMVVAGGASAKLGMNAKDHVKKGLPVLEDVVGGFAVLVSENDGVNPVIRT DLTGKHTVGTGSSPQAVMTALITSGLDRANLKITDVDVYSVEMQNPDITKPAGAGDVP EANYKMIGALAVKRGDLEKKELKDFVSNKGLPGWAPTQGHIPSGAPYIGFLIDDLTTG NRNRAMIVGKGSLFLGRMTNLFDGVSFIAERNTGVTEETSGISKDEIKKIIAESMKKL ALDMLEE" gene complement(8186..9235) /gene="grdB" /locus_tag="grdB" /db_xref="2631385..2632434" CDS complement(8186..9235) /gene="grdB" /locus_tag="grdB" /product="glycine reductase complex component B gamma subunit" /translation="MGKLKAVHYINQFFAGIGGEEKADTKPHVAETLPPISLQLDKLL GEDIEIVGTVVCGDSYFNENIDSASEEVLSMVKGFEPQLFIAGPAFNAGRYGVAAGTI TKVVKDALNIPALTGMYVENPGADMFKKDVYVVETSDSAAGMRKALPKIAKLAVKLAN GEEIGTPKDEGYIARGIRVNYFHEDRGSKRAVDMLVKKIKGEPFETEYPMPNFDRVDP SKAVKDLSKCKIALVTSGGIVPKGNPDRIESSSASKYGTYSIAGVMDLTEETYETAHG GYDPVYANLDADRVLPVDVLRDLEKEGVIGKLHETFYTTVGNGTSVANSKKYASEIGA ALVADGVDAVILTST" gene complement(9267..9740) /gene="grdA" /locus_tag="grdA" /db_xref="2632466..2632939" CDS complement(9267..9740) /gene="grdA" /locus_tag="grdA" /product="glycine/sarcosine/betaine reductase complex component A" /translation="MSLLSNKKVLIIGDRDGIPGPAIEECVKTVEGAEVVFSSTECFV *TAAGAMDLENQNRVKDAADKFGAENVVILLGAAEAEAAGLAAETVTAGDPTFAGPLA GVALGLSVYHVVEEPIKSLFDESVYEDQISMMEMVLEVEEIEEEMSGIREEFCKF" gene complement(9852..11138) /gene="grdE" /locus_tag="grdE" /db_xref="2633051..2634337" CDS complement(9852..11138) /gene="grdE" /locus_tag="grdE" /product="glycine reductase complex component B alpha and beta subunits" /translation="MRLELGKIFIKDIQFGDVTEVKDGVLFINKQEMLQEIGGDEHIK SIDIELARPGESVRITPVKDVIEPRVKVEGNGGIFPGIMSKVDTVGEGKTHALKGVAV VTTGKIVGFQEGIIDMTGEGAKYTPFSKLNNVVVIAEPIDGLKQYAHEKAVRMIGFKA AMYLGEVARNLTPDEVSVYETKPLLESIKEYPELPKVGYVYMLQTQGLLHDTYVYGVD AKQIVPTLLYPTELMDGAIVSGNCVSACDKNPSYVHINNGVVEDLYARHGKDINFVGV IITNENVYLADKERSSNWTSKLCKYLGLDAVIVSQEGFGNPDTDLIMNCKKIEMQGVK TVIVTDEYAGRDGGSQSLADADVRADAVVTGGNANQVVVLPKLDKVIGHLEVVDVIAG GSDGSLRADGTIEVEIQAITGATNETGFGHLTAKGY" gene complement(11407..11724) /gene="trxA2" /locus_tag="trxA2" /db_xref="2634606..2634923" CDS complement(11407..11724) /gene="trxA2" /locus_tag="trxA2" /product="thioredoxin" /translation="MLDLDKATFEEEVLNAEGFVFVDFWSEGCEPCKALMPDVHKLAE TYGDKIKFCKMDTTKARRLAIKQKVLGLPTMAIYKDGEKVDEVTKDDATVPNIENMIK KYL" gene complement(11809..12756) /gene="trxB3" /locus_tag="trxB3" /db_xref="2635008..2635955" CDS complement(11809..12756) /gene="trxB3" /locus_tag="trxB3" /product="thioredoxin reductase" /translation="MENVYDLVIIGSGPAGLAAGLYGARAKLKTLILEKDKTGGQIVI THEIANYPGSVPNATGPSLIARMVEQCKEFGAEMLRDNIVDTELDGDIKVLKGEKAEY RAKAVIIGTGATPRKIGCPGEKELTGKGVSYCATCDADFFEDFEVFVVGGGDSALEEA MYLTKFARKVTIVHRRQGFRCAKSVEEKAKANPKIEFLLDTVIEEIKGDGILESVVFK NKVTGETHEYFADEEDGTMGVFVFVGLDAQTDLFKGKVDMDEKGYIITDEDMRTNIPG VFAAGDCRSKTLRQVVTATNDGAIASIVAEKYIDEKFGN" gene complement(12852..13223) /gene="grdX" /locus_tag="grdX" /db_xref="2636051..2636422" CDS complement(12852..13223) /gene="grdX" /locus_tag="grdX" /product="putative glycine reductase complex component" /translation="MIIITNNPKVKEEVQGREVLFKDTTYIGILEASRDLIHEGYELL SHPLYGSVKPNETPYRTVILKKGNRLDINSLTLIEEAIITASKFQDNKKTPKWTENVQ DDFRVIDYDIFYNTIQRMQYE" gene complement(13769..15463) /gene="" /locus_tag="" /db_xref="2636968..2638662" CDS complement(13769..15463) /gene="" /locus_tag="" /product="putative oligoendopeptidase" /translation="MKFSEFKYERPNYNSMKKEFLSCVEDINNSRNYKEQQKNIHKIN LLRNKIETLSNIASIRYSTDTFNKFYKEEKNYWDEYMPLYEELNSHFYNAIVNSKFKY DLIKEFGEQFFTIVEYSLKSFSKEIISELQEENKLCSEYTRLLASAEIMFDGNIRNLS GMGKFMYSKNRKTRELANKAYYNFFEENETKFDDIFDKLVKLRDKISKKLGFEDFVEL GYVRMMRSDYREDMIKNVRKQVLKYVVPMANELYEKQAKRIGLEYLSYIDEGVEFLTG NASLKGDSRYIIQNGKRMYSELSKETNEFFDFMLENELMDLETKKGKGAGGYCTYIPD YKSPFIFSNFNQTADDIDVLTHEAGHAFQLYMSRWIDMPEINFPTLDSCEIHSMSMEF ITWPWMDLFFKEDTDKYKFTHLSSSIKFIPYGVIVDEFQHYIYKNPNVDKSKRKEIWR FLEKKYLPHRKYGDNSFLERGCWWFKQGHIFKNPFYYIDYVLAQICALQFWKKMIQDR DAGWKDYINICKVGGTKSFLDIVSMGNLYSPFDDGCIESIIGDVKSWFDEINDSKL" gene 15955..16776 /gene="" /locus_tag="" /db_xref="2639154..2639975" CDS 15955..16776 /gene="" /locus_tag="" /product="putative hydrolase" /translation="MYKLIALDIDGTILNTQKRITPEVFESIQEAKRAGAKVVITTGR PLPGVKELLNQLNLTDEGDYVICFNGAIIQEVKSEKIIHDVEMTLDDFDFIYNNVCKK YKTKIHINTMTNLITPNEAPGKYTLHEAKLNNIEVKYIQKDKIDESIKICKIMIVDEP ERLEEIIQQLPKNLFNKYTIVRSAPFYLEFLGKTTNKGTALKTLCTNLNIPIENAIAV GDEENDQHMIKYAGLGVAMGNARNSIKEIADYVTDTNNENGVAKVINKYILNKAI" gene complement(17068..17553) /gene="" /locus_tag="" /db_xref="2640267..2640752" CDS complement(17068..17553) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MSQIEKYNSLDNTQQKIRISIMDMIIDKGSSVTLQEVTEYVSKK LNIEKEYIERTLQYFIYENIMVVDGNSINFIYPVSALQTNHKVTLRDNRSFSAMCAID AIGTSCTFNQDIKINSICSATGKEIEVIIKNEKIEYVNNPNLRVLHINLDKHLNWAAS C" gene complement(17566..18336) /gene="" /locus_tag="" /db_xref="2640765..2641535" CDS complement(17566..18336) /gene="" /locus_tag="" /product="putative aliphatic sulfonate ABC transporter, ATP-binding protein" /translation="MEVCRLMKLSVRDINKTFVNNRVHTKVLEDISMDIDDGQFVCLL GPSGCGKTTLLTIIGGFQKSERGDVFINDKRVKKPGIDRAFIFQNYALFPWKTIRGNV LFPMKQQKIPKEKREEMLEELLVMSDLKGKEKLFPHQLSGGMKQRVAMIRALACNPEV LLMDEPLGAVDFQMRQNLQEELERIWIKKKITALMVTHDVDEAVYMSDRVIVMSRDKG RIIDDINIDIPRPRIRGSQKYEEYKNKLTDTLSKCYEV" gene complement(18318..19061) /gene="" /locus_tag="" /db_xref="2641517..2642260" CDS complement(18318..19061) /gene="" /locus_tag="" /product="" /translation="MDILYKIILLVIIFLVWHFAAKDIGSSLLLPMPVDVIKGFFFCV TDAETVTNLFITLQRVLKGFMYALLFGLPIGFIMGFSKTFERVLSPVVDSVRQVPIMA WVPLTIVWFGIGDGPTIFLIAFSGVFPIILNTIQGVRAISKDYYNAARSMGASPIVIF TNVIVPASLPDILTGSRIAISTGWMSVI*AEFIATSAGLGYSMVQAQTLMHTDVLIGL MIFAALIGFIIDRVLKFINKILCRWRFAD" ORIGIN 1 ttacattgga agtttgtgta aaactataac caatataact ttagttaata atgcaaatgg 61 atacgtagca ccataacctg ctgctgggtc atcactatca agagcatcaa cagcagctcc 121 aagacctggt gttgatgtca taccaccaca gacagctcca gataataaaa tccaatttaa 181 tttaaatacg tatttgccaa ctaagaatcc tatcatcata gctgtaacac ctactgctat 241 tgctactaag gctaggtgca taccagatgt cataattgaa tcaactactt ttccaccata 301 tcttaatcca actattgcta agaaaaatac tagccctatt tgttttaaaa tatttaaaac 361 cttttcttcc attctgaaat ttactacccc tatcttacct atatatccaa gaactagaga 421 tacaattagt gaacctcctg ttgcgcctag tgtgaagtac cctagtggtc ccataaatac 481 atgtattcct ccaactaagt atccagctaa acatgtcaag aaaaatgtta ttatattaaa 541 tggaacttct ggtatcgttt taccagaaac actatctctt gcttccttca tttccttctc 601 atattttctt ctttcttctt ttaggtccat cctaaataat tttggaagga aatttacacc 661 taagattact attaaaactc caaaaggata tgcgactgca tgacctatac caacaccagc 721 ttcagcatat gcaatatact tatctatttg ctcttgagtc agtgatgtag ttgtattcac 781 atccaatttg ccttctgggt cgactacttt taaaatttct tttttatctt ttattgaagc 841 tttttcaaat tcttttgata catcttctgc atgtttacca gctgtttcta aagcagcagc 901 taatccaggc gaacttgtta atgctcctgt gtaaacgcca gaaacttcat aagcactact 961 tcctttatca cttgatagta aagtcattgc ataagtcata gagccaccta taaaagttat 1021 aagaactcct aaaattacaa atcttgctcc atacttcttt aatacagctt tcatatcttt 1081 tgctgccaat agaccaactg ctgcaacaaa tattattaaa aagaaatcaa agaagtcaga 1141 agaaataatt ccattcccca tcattacagt tgctgcctta tatcctgctg ctgtttctcc 1201 ttttgctatt attagattcc ccaagctata tgcaagccat ccaataaata atcctgtaaa 1261 taatgctcct gataccccaa aattaaactt cccaaattta atttttccaa ataaaattcc 1321 tgtaattact gcagcaaaca taaggacaaa aggattcatt aaaaaatcca tcaattcaaa 1381 cttcactaaa tcactccctt tcatttttcg ttattaaatt aacaaatatt attaaaaaat 1441 atatttctcc tttctcccca atactctatt ttgttattaa attaacattt ctgattaaaa 1501 aaattttatc ttgttaatat cacttttttc tttatgattt aattaacaat ttaattgtaa 1561 aaataatttt tattttctaa tagataattt tttgatattc gttgatataa ctgtaatata 1621 gattgattta ctctaaacca taccagctat tctcttttgt taatttaata atagcactat 1681 tcttaataga ttgaaaatat caaaaactta tgctatgata gtttaaaact attctatttt 1741 tttacaacaa tatacaaaac ttatgctatt gttaattata tacttgtcac taatatgtaa 1801 atgaaaggaa ctaataccaa atgaatataa actatttata ctattttcaa actgtctgta 1861 aatataaaaa catgactaag gctgcggaaa gtattcatat ttctcaacca tccataacat 1921 tagcaattaa agaattagaa aaagaacttg gctttgaact tttttacaga ataggtaata 1981 aaatagaatt aacgcctgaa ggaaaaattt ttttagacaa gtcaaaacat tttataaaac 2041 aatttgagga ttttcaatgt gacgcacttg atttaggaaa aaagagaaaa gcttctctca 2101 aaataggtat tcctacagtt ttaggtacgt ttttgctttc aaaaatactt cctagattta 2161 atgtaattta tccagatata gagcttaaaa tttttgaagt tccaacattt gttggagcta 2221 aaatgattga agaatctaca cttgattttt gtattggtat aattgacagt gatatttatg 2281 atgatataga ttcaaagaca atctataaaa cagaattgta cttagttaca aatcccaaaa 2341 atgaattggc aaaacatccc attatatcaa attatatgtt aaaaaatgta ccttttgtaa 2401 tcttatctga aggttcttat cactataaga ttattacaaa aagacttgaa aaagctaagc 2461 caaatataat tttacactca aatcaacttt ctaccatacg ttatttacta gaaaatgact 2521 tggcttcaac aatattgtat aaagaaatat ttcaaaatac agaaaatctc tgttcaatac 2581 cattagaacg tgcaattact gcaaatattg gagttctttg gagaagaaat caatacatat 2641 ctcatagtat gaaacttttt attgagtata tggcatctat tcatataaac taaatttata 2701 ttatacagat ataatatttt gtttaaatac aatgttaaaa tattttaata aatagtatag 2761 tttagagtat cagtataaaa atacaatata gaatgttata gaattataat tgtatacatt 2821 taaatctaaa tattattata ctgatacttt ttaaaatacc ttttattgat aatacttttt 2881 taatcaggtt tacttggaca acctagcaaa aaacccacgc atcctgagac aaaatctctc 2941 atctgtgaaa tagtacctaa agaagctgat gttgtagttg taaaatttct tacaacaaaa 3001 agtactgtta atgctgctat acaaattaca gtagctataa taatttgcaa ttcactagtt 3061 tctccttctt caaaaccttc attattatta ataggtattt tcttttcata attatcagct 3121 tctgaagtaa atccaatggt atttttgaca ttcattatat tattttgact agactcttga 3181 ccttttgggg gtaaattatt atctataaaa agatttgaag atacatcagt atttgtatac 3241 ttccttaaag gtctctttat aaaattagca cttaaaaaat acccaaatat agctgctgaa 3301 gtggttctta ctactacatc aatagttgta gtatcttgtg aatttacttc attaacaaat 3361 aaattatata tagattgaaa cattaatatt gccattacaa ttataaggca tctatcaatt 3421 aatttgattt tataccaggc tttttttata ttttttataa atttatgttt tttatacata 3481 tatactatca cctcttacaa taaaattaag ccctctttac tataatatgt aaatagagct 3541 taatagtgag attatgttat attttatgta aaaaaatata tataaattaa attatttgtc 3601 taaaatcatc aaatctttag ggaatttagt aagtctttct ggaccatttt tagtaatcaa 3661 aacagtatct tctattctaa ctccacccca tccagggaaa taaatacctg gttccattgt 3721 tattatacat ccctcttcta tgattttatc accataatta ccaatgaaag gttcttcatg 3781 aacatcccta ccgactccat gtcctatacc ttgatagtaa tagtcttcat attttttgac 3841 aacttttctt atctcagcat ctggaattgt cgcatgtaca ccagctttca tgttctcaac 3901 ccctacattt tgagcttcct taactaaatt atatatttct aattgctttt cagaagctcc 3961 tccaactata aaagttctag ttgtatcaga tatatagcca ttatacatag caccatagtc 4021 tataagtaca aaatcacctt tttctataat cttatcacta ggcttaccat gaagcaatga 4081 agtctttgct cctgatatca gtatagtttc aaaccctata ttttgtgctc cgttcatttt 4141 cataaagtac tctaactttg tagccagttc aatttcgcta actccagctt ttatatgtgg 4201 aatcaattct tctaatgcct tatccgctat ttcacaagct tttcttgtat ttttgatttc 4261 atctttgtct tttacatatc tcaaagtctc tacaatattt tctgtaggta ttaattctcc 4321 attatccttc tcaatcagat ttttaagttc ttcatattta tcaaacacta tattagttct 4381 ttcaaaccca agtttcttta tacccacttt atcacataca cttttaactg cctttgccac 4441 acttctatca aaattatgcc aatttataat ttcaaaatct ttgcaaacct tttctgcaag 4501 ctccatatat ctactatcag taactaaaaa gtttccatct ttgcaaatca ctgcatatgc 4561 ttcttcatca ggaaaaccac ttatatagtt tacattagtt ttctttgtta gatatagtgc 4621 atcaacacct ttagttccca acaatcctac tacatttttt actctgctca tgattttacc 4681 tccaaataat aaattttatc ttaattatat tatatcacta attaatctta tttttatcta 4741 acagatactt tattcctaaa attttttcat attttattaa tttcatttta atacttcatt 4801 agtttttatt tagttagaaa gcttaatttt aattgaataa atataataaa ttagctagag 4861 aatcaaataa atggattgtg ttaatatata aatattgaca agatataaaa taaaaagaac 4921 atataattat aatcaataaa attataacta tatgttctta tttacatata aaaaatgtac 4981 ttattttgca gtatatccag ctttaactaa agtttcaact gctaagtctc ctttagcttc 5041 atttactaaa actattggac ctgtacaacc cataccactt tcagcataga ttccgttttt 5101 ccataactca gatactgcat cttctaaatc cattatatca acaccagcta tttgacgagt 5161 aacaatttct ttatctggca ttttaacttc tactttttca gctttaactt cttttttagt 5221 aagagaggat ataatgtcat caaattttgc ttttttaacc tttgcaaatt catttcttgc 5281 aacattactt atatctccct ttacaacatc ataagcgtat tttaaagcat ttgctactac 5341 cggagaacct gatgctcttg atactataag tacctttcta tcatagtctt ctccaactcc 5401 aggtccgtat ccaaagcctt gagcttcata atctccacct gtagtatatg aagaaaatac 5461 tttcataaat atatttccag ataatgtatc agtaaccata acatcaggtg cacctacaag 5521 taaatcatta cctctcatta cacatccacc atctgctcta attgaatccg caaactccat 5581 gtcatatcca ttatctttta attcttttaa gcacttctca acttgtcttg ctccatcaac 5641 attaagtatt ccaacttttg ggcatttgtt acccattgat ttagctgtag caataccata 5701 aatggcattt cttaccattg cctctattct attagtagca cttgttcctg ttgttgttgc 5761 aagtatcatt tcttttcctt ttgctggagt tattactcta cctactgtag atacacctat 5821 tggaaaatta taatgcatag taacacaagc atcaatatat cctgaatcta ataattcttc 5881 catttttgca tgcatttctt tttcatcatt aacttcaact acttcaaggt cagtttccac 5941 ttttggtcca ataagcacaa tatcaaataa attagatttt gctaattgtg caccattaac 6001 catgttttct acaccatgtt cacttccaag tgtagtaaca ccaattttta cttttttgcc 6061 aaattcgccg ctttctattg cattagctac ttctaagaat acatctgcga ttactttttt 6121 tgacatatcc tcacccctat tcttctaaca tatctaatgc tagttttttc atagattcag 6181 ctattatctt cttaatttca tccttagata ttcctgaagt ctcttcagta acacctgtat 6241 ttctttcagc tataaaagat actccatcaa ataagttagt cattcttcct aagaataaac 6301 taccttttcc aactatcata gctctatttc tatttcctgt agttaaatca tctattaaaa 6361 atcctatata aggagctcct gatggtatat gtccttgagt tggtgcccat cctggtaatc 6421 ctttgttaga aacaaaatct ttcaattctt tcttttctaa gtctccacgt ttaacagcaa 6481 gtgcccctat cattttgtag tttgcttctg gaacatctcc tgctcctgct ggcttagtta 6541 tatctgggtt ttgcatttca actgaataca catcaacatc tgttattttt aaattagctc 6601 tatcaagacc tgaagttata agtgctgtca taactgcttg tggtgaagaa ccagttccaa 6661 cagtatgctt acctgttaaa tcagttctta taactggatt tacaccatca ttttcagata 6721 caagtactgc aaatcctcca acaacatctt caagtacagg aagacctttt ttaacatggt 6781 ctttagcatt cattccaagt ttagcacttg ctccacctgc tactaccatt acatttttat 6841 gtatgccagc ttttactaaa gctgctgctt gaattaatgc atgagttggt gctgcacaaa 6901 atcctcttgt gtcagaacca gttgcattct gaagtcctgc tatctcagct attgatttag 6961 caaagtttcc tccacctctt tggtttatat ctccacaagc ttcttctgaa cactcaataa 7021 cataatctat ttcagcaggg tctattttgc tatgtcttag catttgaata gcagataaaa 7081 ctccagatgc ttttactact agattttcaa acattgtatg ggcatttaag ttaacatcta 7141 catcatgtgc tctttttaca taaccaacaa attttccatc atggtataat ccttcagcta 7201 tgtgtgttgc tactaattct ttaccttctt ctatatcatc accctttaat ttacctacaa 7261 atggtgcaat ttcagggtag ttattttcga tttttggctt tacttcatca ataaattctt 7321 gtgataattt tactaaatca aatgcatcac ttatttgcat taaagctatg aactcatctt 7381 gaggcattat ttctccaaac ttaccatttc tagttccctc aatcttttgt tcacaccatg 7441 gcattggtaa atctcttaat tcttctggtc ttctatttcc tatataaact tgatttggca 7501 tgtagttaac tacatcttca taacttctta tatgattact tacttctttt aaaaattctg 7561 aatctgaatt tgttgctctt tcaactgtac aagtacttcc attttgcact atcatatctg 7621 gagtatgaat aagtacatag cctgcccctt ttaaaactgg ataagtcatt ttgtgcacct 7681 ccataaattt tatgaacact tattttttaa tcttattaaa cttattaaaa gctctaatca 7741 ttgtatttta ttgtatattt gattctatta ttgtttatgt attttggcat tttttaagat 7801 ttcatgaatg aataactcca atttatccat tcatgaaatc tatattattt tttttgtgta 7861 tagttatttt ttatttttag tgtgtgttta tatttttatc tatataatat atgtgtgtgt 7921 tatttttatt tttcaaatac tgtttgacca tctacttctg tagttaaagc atttaatgct 7981 ttttctacaa ggcctcttct tagggctttt tcttctgtag ggtcaagcgc tggatttcca 8041 agtggatgag gtattgctat agttggaact attctattag cccctactgt taatgaaata 8101 ggtactactg tacacatatg aactactgga agtccagttt tttctatttc ttttaccatc 8161 gttgcaccgc aacgagtaca agtacctcat gtagaagtta atattactgc atctacacca 8221 tcagccacta atgctgctcc aatttcagaa gcatattttt tagagtttgc aacagatgta 8281 ccattaccta cagttgtata gaaagtctca tgtaattttc caattacacc ttctttttct 8341 aaatctctaa gaacatcaac aggtaatact ctatctgcat ctaaatttgc atacactggg 8401 tcatatccac catgtgcagt ttcataagtc tcttctgtta aatccataac tcctgctata 8461 gaataagttc catatttaga agctgaagaa gactctattc tatctggatt tccttttgga 8521 actataccac cagaagtaac taaagctatt ttacattttg ataaatcttt tacagcttta 8581 cttgggtcaa ctctatcaaa gtttggcatt gggtattcag tttcaaatgg ttcacctttt 8641 attttcttaa ctaacatgtc aacagctctc ttagaacctc tgtcttcatg gaagtagtta 8701 actcttattc ctctagctat gtatccttca tctttaggag ttccaatttc ttctccatta 8761 gcaagtttta ctgcaagttt agctatctta ggaagtgcct ttctcatacc tgctgcagaa 8821 tcagaagttt ctactacata aacatccttt ttgaacatat ctgctcctgg attttcaaca 8881 tacatacctg ttaaagctgg tatattcaaa gcatctttta caactttagt tattgttcca 8941 gcagcaaccc catatctacc agcattaaat gcaggaccag ctatgaaaag ttgtggttca 9001 aaacctttta ccattgataa aacttcttca cttgcactat caatattttc attgaaatag 9061 ctatctccac aaactactgt tccaactatt tcaatatctt cacctaataa tttatcaagt 9121 tgtaaactta ttggaggtaa agtttctgcc acatgtggct tagtatcagc tttttcttct 9181 ccacctatac cagcaaagaa ctgattaata taatgtactg cttttagttt tcccatctct 9241 tagtttcacc ccttttgctt ttaggcatta aaatttacaa aattcttctc ttataccaga 9301 catttcttct tctatttctt caacttctaa aaccatttcc atcatactta tttggtcttc 9361 atatacactt tcatcaaata atgattttat tggttcctca acaacgtggt aaacacttaa 9421 tcctaaggca actccagcaa gtggtccagc gaaagttgga tctccagcag ttactgtttc 9481 ggctgcaaga cctgcagctt cggcttcagc agcacctagt aaaatcacaa cattttcagc 9541 tccgaattta tcagcagcat ctttaactct gttttgattt tctaagtcca tagccccagc 9601 agctgttcag acaaagcatt ctgtagatga gaaaacaacc tctgctcctt ctactgtttt 9661 tacacattct tctatcgcag gtcctggtat accatcacgg tcacctatta taagaacctt 9721 tttattacta agtaaactca taataatcct ccttattata tttctaatat atttttatat 9781 atctataaca cttattataa ttatctataa tatgttttat taacattact caatcgttta 9841 ataaaatact tcttaatatc ctttagcagt taaatgacca aatcctgttt cattagttgc 9901 acctgttata gcttggattt caacttcaat agttccatca gctcttaaac ttccatcaga 9961 accaccagct attacatcta ctacttctaa atgtccaata actttatcta acttaggaag 10021 aactacaact tggttggcat ttccacctgt tacaacagca tcagctctta catctgcatc 10081 tgcaagtgat tgagaacctc catcacgtcc agcatattca tctgtaacta taactgtttt 10141 aacaccttgc atttctatct tcttacagtt cattataagg tcagtatcag gatttccaaa 10201 accttcttgt gaaactataa ctgcatctaa tcctaaatat ttacataatt tagaagtcca 10261 gtttgaagat ctttctttat ctgctaggta aacattttca ttagttataa ttacacctac 10321 aaagtttata tctttaccat gtcgtgcata taagtcttca acaaccccat tgtttatatg 10381 aacataactt gggtttttgt cacatgcaga aacacagtta ccacttacaa ttgctccgtc 10441 cattaattct gttggatata ataaagttgg tactatttgt tttgcatcta ctccatatac 10501 ataagtatca tgtaataaac cttgagtctg aagcatgtaa acatatccta cttttggaag 10561 ctctggatat tcttttattg attcaagaag aggtttagtt tcatatactg aaacttcatc 10621 tggagtaaga tttcttgcta cttctcctaa gtacattgct gctttgaatc ctatcattct 10681 aacagctttt tcatgagcgt attgttttaa accatcaata ggttcagcta ttactactac 10741 attatttaat ttagaaaatg gagtatactt agctccttct ccagtcatgt ctattatacc 10801 ttcttggaaa cctactattt ttccagtagt tacaacagct acacctttta aagcatgagt 10861 ttttccttct cctacagtat caactttaga catgatacca gggaagattc ccccattacc 10921 ttcaactttt actcttggct caataacatc ttttacaggt gttattctta cgctttcacc 10981 tggacgagct aattctatat ctatagattt aatatgctca tctccaccaa tttcttgtag 11041 catctcttgc ttattgatga ataatactcc atcttttact tctgttacat caccaaattg 11101 aatatctttt ataaagattt tccctaattc aagacgcata cttgcacctc ctgttattta 11161 atttgtgtat atgcatttga gtttttctca aaattatatc attttacaat ttatcttatt 11221 tttttaaaga tatattattg tgtttttatg ccttaaatct ttattttatt actaaaaaat 11281 atttattgta aaaaaattat tttatttaaa attatttttt taacaaagtt ggacataaaa 11341 acctttttct tcttatcttc agataaaaat agattttttc ttttaatgtt aatactttat 11401 caacatatta aagatatttt ttaatcatgt tttctatatt aggaactgta gcatcatcct 11461 tagtaacttc gtctactttt tctccatctt tgtatatagc catagttgga agacctaata 11521 ctttttgttt tatagctaat cttctagctt ttgttgtatc catcttacag aattttattt 11581 tatccccata agtctcagct aatttatgaa catctggcat taaagcttta caaggctcac 11641 aaccttcact ccaaaaatca acaaatacaa aaccttctgc atttaaaact tcttcttcaa 11701 atgtagcctt atctaaatct aacattttct tattccccct tgaaattttt attttaattt 11761 taaatattat tcattaaatt tacagacact atttcttaat ttacagattc tagttcccaa 11821 atttttcatc aatgtatttc tcagctacta tagatgcaat tgcgccatca ttagttgcag 11881 ttacaacctg tcttagagtc ttagatctac aatctcctgc tgcaaatacg cctggtatgt 11941 tagttctcat atcttcatca gttattatgt aacctttttc atccatatca actttacctt 12001 tgaataaatc agtttgagca tctaatccaa cgaacacaaa tactcccatt gttccatctt 12061 cttcatctgc aaagtattca tgagtttctc cagtaacttt atttttaaat acaactgatt 12121 ctaatattcc atcacctttg atttcttcaa ttactgtatc taataaaaac tctatctttg 12181 gattagcttt tgctttttct tcaacactct tagcacatct aaatccttgt cttctatgta 12241 caattgttac ttttctagca aatttagtta aatacattgc ttcttctaat gcactgtctc 12301 ctccacctac aacaaatact tcaaaatctt caaagaaatc tgcatcacaa gttgcacaat 12361 atgaaacccc tttaccagta agttcttttt ctccaggaca accaatcttt cttggtgttg 12421 ctcctgttcc tattattact gcttttgctc tatattctgc cttttcccct tttaaaactt 12481 ttatatctcc atctagctca gtatcaacaa tgttatctct tagcatttct gctccaaact 12541 ctttacactg ttcaaccatt ctagctatta aacttggtcc tgttgcattt ggaactgacc 12601 ctggataatt tgcaatttca tgtgttatta caatttgtcc accagtcttg tctttttcta 12661 ggattagagt ttttaacttt gctcttgctc cataaagacc tgctgcaagc ccagctggtc 12721 ctgaaccaat tattactaag tcatacacat tttccatttt gacttatcct ccccaattaa 12781 atttctcatt ttatttaata ttaaattaga tttaatattt aggctgtttc aataactttt 12841 taacaaattt ttttattcat actgcattct ttgtattgta ttataaaata tatcataatc 12901 aattactcta aaatcgtctt ggacattttc tgtccatttt ggagtctttt tattatcctg 12961 aaatttactt gcagtgatga ttgcttcttc aattaaggtt aaagagttta tatccaaacg 13021 atttcctttc tttagtataa cagtcctgta aggtgtttca tttggtttta cactcccata 13081 gagtggatga gataaaagtt cataaccttc atgtatcaaa tctctacttg cttctaagat 13141 tccaatataa gttgtgtctt taaacaaaac ttctctgcct tgaacttctt cttttacttt 13201 tggattattc gtaattatta tcattttttt actctctttc aaacttttat ttattacttg 13261 ataaataaaa aacaggaaaa acaaatctcc caatttgtct tccctgttaa aatcattttc 13321 agagccccgt ccaagtacag tcacctttac ctgagaattt catctaatct tttgggtaag 13381 taagattaaa cttgtccctt cggtcgcttt ttataaagca gtctcccata ctcttcatcc 13441 ggattattat ttttttcaga aaatttaaaa ttaagcaatt tatcctttgt tttctataaa 13501 tagctttttt ctatctctgt tgacttaagt atataaacat tctataaaat ttgcaatagt 13561 ttttttatat gtattttgta tacattttta cttttttttc caaatgttga tattgcatat 13621 ttcttgtatt ttcttttttt tttaagtaca aatctttttt agtttatttt atcaatttag 13681 ttaaaaacaa gactattttc acaacaaata atcacttttt atatattttt taatttttca 13741 cttttataca ataaaattct cataattttt tataatttgc tgtcatttat ttcatcaaac 13801 caagatttaa catcacctat aatagactca atacagccat catcaaatgg agaatacaaa 13861 tttcccatac tcacaatatc taaaaatgat tttgttcctc caactttaca gatatttata 13921 taatctttcc atcctgcatc tctatcttga atcatttttt tccaaaattg taacgcacaa 13981 atttgagcta atacataatc tatataataa aacggatttt taaatatatg tccttgttta 14041 aaccaccaac aacctctctc taaaaaagaa ttatcaccat attttctatg aggtaagtat 14101 tttttctcta aaaatctcca gatttctttt cgttttgact tatctacatt aggatttttg 14161 taaatatagt gttgaaattc atcaacaatt actccataag gtataaattt aattgaagat 14221 gataagtgag tgaatttgta cttatctgta tcttctttaa aaaataaatc catccacggc 14281 catgttataa attccatact cattgaatgg atttcacaac tatcaagcgt tggaaaatta 14341 atttctggca tatcaatcca tctagacata tacaactgaa atgcatgtcc tgcctcatgt 14401 gttaacacat ctatatcatc agcagtttga ttaaaattag aaaaaatgaa tggtgactta 14461 taatctggta tataagtaca ataccctcca gctccttttc cttttttcgt ttctaaatcc 14521 ataagttcat tttctaacat aaaatcaaaa aattcatttg tttcttttga cagttcagaa 14581 tacatccttt taccattttg aattatgtat cttgaatctc cctttaaact tgcatttcct 14641 gttaaaaatt ccacgccttc atctatgtaa cttaaatatt ctagaccaat tcttttagct 14701 tgtttttcat aaagctcatt ggccattgga acaacatatt ttaatacttg ttttctaaca 14761 ttttttatca tatcttctct gtagtcactt ctcatcattc taacgtaccc aagctctaca 14821 aaatcttcaa aacctagttt tttagatatc ttatctctaa gtttaaccaa tttatcaaat 14881 atgtcatcaa atttagtttc attttcttca aagaaattat aatatgcttt gtttgctaat 14941 tctcttgttt ttctattctt agaatacatg aatttcccca taccagataa atttcttata 15001 ttcccatcaa acattatctc agctgaagct aaaagtctag tatactctga acacaattta 15061 ttttcttcct gcaattcact tattatttct ttagaaaaac tttttaaaga atactctact 15121 attgtgaaaa attgttctcc aaactctttt atcaaatcat atttaaattt tgaatttaca 15181 atagcattat aaaaatgtga atttaattct tcatacaaag gcatatattc atcccaataa 15241 tttttttctt ctttgtagaa tttattaaat gtgtctgtac tatatcttat cgaagctata 15301 tttgacaacg tttctatttt atttcttaat aaattaatct tatgtatatt tttttgttgc 15361 tctttataat tacgagaatt atttatatct tctacacaac tcaaaaactc ttttttcata 15421 ctattataat tgggtctttc atacttaaac tctgaaaact tcatttaaag cactccttta 15481 caactttact ttattgtatt tataaatata gatttacatg tactatgtaa tactttttta 15541 taaattatta tatatattaa atattcttta tattataatc atgttgaata ataacatatg 15601 attaatggaa ttacaatatt ttataacaca aaactaacta atataacaaa ttaccatcag 15661 tctatttatt caaacttcta actatataat atacatttat ttatattaac aatgcaaacg 15721 ataccattat ttgtaattaa gaattttgga attattgatt acaaagtttt tacattctca 15781 tctcacataa gtaatatttt tatcaaaaat taatattatt aaactttcta aattacttat 15841 ctcttgatat aatagtatac aaaacaaacc atatttccca ctgaaacttt gttcaacact 15901 agctgtgtca acgttttcac aggaaatttg agtatataat ttattggagg ttgatatgta 15961 caaattaatc gcactagaca ttgatggaac aatattaaat acacaaaaaa ggattactcc 16021 tgaagtcttt gagtccattc aggaggcaaa aagggctggg gcaaaagtag ttataacaac 16081 aggcagacct cttcctggtg taaaagaact tctaaatcaa ctaaatttaa cagatgaagg 16141 tgattatgtt atatgcttta atggagcaat tattcaagaa gttaaaagtg agaaaatcat 16201 acatgatgta gaaatgactt tagatgattt tgattttata tataataacg tttgtaaaaa 16261 atataagact aaaatacaca taaatacaat gacaaattta attacaccaa atgaagcacc 16321 tggaaaatat acacttcatg aagcgaaatt aaataatata gaagtcaaat atatacaaaa 16381 agataaaatt gatgaatcta ttaaaatctg taaaattatg atagttgatg aaccagaaag 16441 attggaagaa atcatacagc aactacctaa aaatttattc aataaatata ctatagtaag 16501 gtctgctcct ttttatctag aatttttagg taaaactact aataaaggaa ctgctcttaa 16561 aacattatgt acgaatctaa atatacctat agaaaatgct attgctgttg gcgatgaaga 16621 aaatgaccaa catatgataa agtatgcagg tcttggtgtg gctatgggga atgcacgtaa 16681 tagtataaag gaaattgcag attatgttac tgatactaat aatgaaaatg gagttgcaaa 16741 ggttataaat aaatatatac ttaataaggc tatctaatca tctaaaaaaa ctaaaaatat 16801 acctttagat ttaaatactt ttcacatccc tactctatac taatttatat agtatggata 16861 ttacctatca tttttatcta aaggtcattt ttagtttttc atatatgtat atctatgata 16921 gtaccttttg tttgagttta aatattttat atgattctac tattgcctca ttaatatcta 16981 aacaatatat atcttcatca tcagataatc ccgcttcgtt tgtccaagca tcaaaatcac 17041 tcttcgtcca gaagaaattc attatatttc agcaactagc agcccaattt agatgcttat 17101 caagatttat atgaagcact cttaagtttg gattattcac atactcaatc ttttcatttt 17161 ttataattac ttctatttcc ttacctgtag cactacaaat agagtttatt tttatatctt 17221 ggttgaatgt gcaagaggtt cctatagcat ctatagcaca cattgcgctg aaacttctat 17281 tatctctcaa agttacttta tgatttgttt gcaatgctga tacaggatat ataaaattta 17341 tactattccc atcaacaacc attatatttt cataaataaa atattgtagt gtcctttcta 17401 tatattcttt ttctatattc aactttttac ttacatattc agtcacttct tgaagtgtaa 17461 cactagaacc tttatctatt atcatatcca taatagagat tcttattttc tgttgtgtat 17521 tatccaaact attgtatttt tctatttgac tcatgtctac tcctctttaa acttcataac 17581 actttgataa agtatcagtt aatttgtttt tgtactcttc atatttttgg cttcctctaa 17641 ttctaggtct tggaatatct atatttatat catcaataat tcttccttta tctctcgaca 17701 ttactataac tctatcactc atatatacag cttcatcaac atcatgagtt accattaatg 17761 cagttatttt cttctttatc catattcgtt ctagctcttc ctgtaaattt tgtctcattt 17821 gaaaatctac agctcctaat ggttcatcca ttagtaatac ctctggatta catgctaaag 17881 ctcttatcat ggccactctt tgtttcattc ctccagataa ttgatgcgga aacagttttt 17941 cttttccttt caagtctgac ataaccaaaa gttcttctag catttcttct cttttttctt 18001 ttggtatttt ctgctgtttc ataggaaata gaacattacc tcttatagtt ttccaaggaa 18061 ataaagcata attttgaaat ataaaagctc tatctatgcc cggtttttta actcttttat 18121 catttataaa aacatctcca cgttctgatt tttgaaaccc acctattata gtaagtaaag 18181 ttgtttttcc acaacctgat ggtcctaaaa gacagacaaa ttgtccatca tctatatcca 18241 tacttatatc ttctaaaacc tttgtatgta ctctattatt tacaaatgtc ttatttatat 18301 ctcttacact taacttcatt aatctgcaaa cctccatcta caaaggattt tatttataaa 18361 ctttaatacc ctatctatta taaatcctat taaagctgca aatatcataa gcccaattaa 18421 tacatctgta tgcattaatg tttgagcttg taccattgag taaccgagac cggcactcgt 18481 agctataaac tcggctcaga taacagacat ccatcctgta cttatagcaa tccttgaacc 18541 agttagtata tctggaagag atgcgggaac aattacattt gtaaatatca caattggcga 18601 tgctcccata cttctagctg cattataata atcctttgat attgctctta ctccttgaat 18661 agtatttaaa attataggga aaacccctga aaaagctatt aaaaatattg ttggaccatc 18721 tcctatacca aaccatacta tagtaagagg aacccatgcc attattggaa cttgccttac 18781 agaatctact actggagata aaaccctttc aaaagtttta gaaaatccca taataaatcc 18841 tattggaagc ccaaacaata atgcatacat aaaaccttta agtactctct gcaatgttat 18901 aaaaagatta gtgactgtct ctgcatctgt cacacagaaa aagaaacctt ttattacatc 18961 tactggcatt ggaagtaaca aagaactccc tatatctttt gctgcaaaat gccagactaa 19021 aaatataata actaatagta ttattttata taaaatatcc at //