LOCUS NC_012623:29 18786 bp DNA linear BCT 06-SEP-2013 DEFINITION Sulfolobus islandicus Y.N.15.51 chromosome, complete genome. ACCESSION NC_012623 SOURCE Sulfolobus islandicus Y.N.15.51 chromosome, complete genome. COMMENT locus start: 2774910; locus end: 2793695 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.953289; n0_4mer:D = 18.513990; n0_4mer:PS = 33.002117 FEATURES Location/Qualifiers source 1..18786 /organism="Sulfolobus islandicus Y.N.15.51 chromosome, complete genome." gene complement(1..840) /gene="" /locus_tag="" /db_xref="2774910..2775749" CDS complement(1..840) /gene="" /product="hypothetical protein" /translation="MEIEIKTPSATVKINNDNKQTEIINGRDRIVIGRVYYYLTKTIF LIPRLYGITAKEPLVNWKNEFERQFTHILTNELSLAKLLTLELYFKITSPKMSIIGTI QNGKVEAKVELKVLPELELQEDKIRSLVKIDSFYFSDINKKRPYIIPAIRAGLVASFY KFLPIRFEGAPGIPKTLGIISDFINSMVLPQGYSEEVLAHKIYIKDDEVYCDDNILYN ADSSVLSLFPIVYFIKNSSNNDIIVIEQPEVHLEEFKETLKELLKMSKAKLVLVSNEA IST" gene complement(1081..3453) /gene="" /locus_tag="" /db_xref="2775990..2778362" gene complement(1901..2830) /gene="" /locus_tag="" /db_xref="2776810..2777739" CDS complement(1901..2830) /gene="" /product="Transposase, ISC1234/ST1916" /translation="MKPWIEYYNLPVPYDKLSSRHKTLLKMHYILITSKALSSLDLYI LRVLIVMMIWQCSYRDVEAYYYTDIVVRWFLGERKSKSENHRRAKKLRGEIKKAFKEY AKELEEKLSKLENYLPSSALYGKVNKLWAIDSNIIEVPFGKRNKETLKKKLELNLRQG KFREAANLIYYYMRAKIHRRFKGEFAKKRGRSFFGFKVLYAISPTMILHAIQVEFANF PDNKVGFGMSGYKVVDRGFLGMPSTWIIGFSSFRRYVEFFGIFLKRYWRPYAINKDMV EVFVYVIGIIYNSLIYTSVLAKVPQEEFVKLSS" gene 3557..4283 /gene="" /locus_tag="" /db_xref="2778466..2779192" gene 4364..4786 /gene="" /locus_tag="" /db_xref="2779273..2779695" CDS 4364..4786 /gene="" /product="hypothetical protein" /translation="MIIRRKNAKALSGAVTALILVIASVIIALVVVAFAFGLFGAFAG QGTVTQVGTATLNAGTKSLIVTLKNTGATTQVTGVIINGNLASVSGQVTISAGESTYS IALSVSTSTLQNLVGSPISLTLQLSNGQTVTVSAIVTS" gene 4903..5268 /gene="" /locus_tag="" /db_xref="2779812..2780177" CDS 4903..5268 /gene="" /product="hypothetical protein" /translation="VEYPYFDLKTARELLPWLRDRLIQLRKIKNEIEILLVNGDKYAL QQYASETKKIIDEIISKGIILRDIDIGLVDFPAIINNKPAFLCWKIDEGDIKYWHYTD EGFRGRKRLTGYEDILSLR" gene 5301..7490 /gene="" /locus_tag="" /db_xref="2780210..2782399" CDS 5301..7490 /gene="" /product="molybdopterin binding aldehyde oxidase and xanthine dehydrogenase" /translation="MYVGERVKRKEDLKFITGSGRYVDDIEYPGTLYLYIVRSNITHA KIKKIDVSDALKVNGVIGVITGLTIPFENRPRNWPMAKDEILYVGHPIAAILATDKYT AADAADSVQIDYEELPAVIDPEKALKDDVKAVEGKSNIAYKKVYNAGDPDKALSNSDI ILEEKLEISRVYPSPMETRGLLSVYQEGSLLVYASTQSAHYMRRYLLSAFGNMVRDIR VIQADVGGAFGAKLFPYAEDFITVYASLQYKRPVKWVALRSEDIRGMYHGRGQIHKVK FGAKKDGTLTAMIDDAVIDLGAASHGTYLVDIAATMLTGPYKVRDLRVNAYGVYTNKT PLDQYRGAGRPEAAFVYERIMDIISDELKLDPIYVRKRNLITELPYVNPLGLKYDSGN YLKLLEKAEKVYREFEERANELRKQGRRIGAGLSFYLEQNNFGPWESASVRIKADGKV QVIIGASPHGQGTETGIAQIVADELEISVDDVEVIWGDTAIIGEGFGTYGSRSLTLAG NAALLAARRVKEKALRLAAQFMKSDVQELEYKNGEVINPKSGRTMSLKEIATRNMASL GGIWEYKEEPGLEASGYFGFDNLTYPYGSHVVLTEVDDSGKVKILDYYAIDDIGTVVN PMLAEAQVIGGVIQGFGESIFEEIVYDENGNLLTGNLFDYAIPTAVEAFNIKWEYMEE GKSNAPLPAKGIGEGATIGTPPALIRAIEKAIGKRLTRLPSKLENLI" gene 7583..7990 /gene="" /locus_tag="" /db_xref="2782492..2782899" CDS 7583..7990 /gene="" /product="Rhodanese domain-containing protein" /translation="MTQVIESYSSPFYKNIIDLPPSMVRKLWKSGKIIILDIRTPQEY EDHHIPGAILAPLDYLEHLTELFEDREVAVVCEHGNRASYATYGMPHLYKKKAYYMIG GMALWMAMGYEVESGMDENGVLWQKILEMKFNY" gene complement(7980..8378) /gene="" /locus_tag="" /db_xref="2782889..2783287" CDS complement(7980..8378) /gene="" /product="hypothetical protein" /translation="MRKGLSDSLTMMIVILASVILAITVISILFGYLGYFGSSYGEVR QIGTALITQDGKLNITLENSFSNAKIVGIIYSTTLHNIDYTLSIGQHKYTINTGFTFP NGLQTVTLTLVIVTNQNTIYVPVEAQLVNS" gene 8684..11035 /gene="" /locus_tag="" /db_xref="2783593..2785944" CDS 8684..11035 /gene="" /product="peptidase M1 membrane alanine aminopeptidase" /translation="MIKVNRYEIFLDFSFQTGDYKGYEKIEMESDEETVVLDAVGLKI LKVKVNEKEIEFSQDESKVNVKSGSFSGILEIEFEGKVAERKLVGIYKASYKDGYVIS TQFEATHARDFIPCFDHPAMKAKFKLTVRVDKGLKVISNMPVVREKEKNGKLVYEFDE TPRMSTYLLYLGIGNFEEIKDEGKIPTIIVATIPGKVQKGRFSMQISRNSIEFYGKYF EISYQLPKVHLIAIPEFAYGAMENWGAITFRETALLADDSSSVYQKFRVAEVVAHELA HQWFGNLVTLKWWDDLWLNESFATFMSHKAISQLFPSWNFWGYFVLNQTSKALEKDSV STTHPIEAHVKDPNEVEQMFDDISYGKGASILRMIEAYVGEENFRRGVVNYLKKFSYS NAQGSDLWNSISEVYGSNISPIMADWITKPGYPMVRVSVSGNRVNLEQERFSVLGNVE NLTYKIPLTMEVNGKIVTHLLDKERETITFEEDIKSFKANVNRTGFYRVLYNSYLVFN AKLSELDKWGIINDYWAFLLAGKIDFKEYERIISKFFNDKDFLPVNELSNELFTLYAI NPDKYQGISKEFHRIQLKNWRNSKDELGRLTYSNILYRLAAMDDEFSLGLSEMFRFYD SLDSDTRQGVAVAYAITYEEDAIDELLERYRKESFDEEKLRYLTSMLFFRKPYLVGNT LSLILSGEIKKQDIPYTLSVVSYNPYAKSAVLSWIKMHVNFMREAYKGTGILGRRLAE VIPLIGIGAEKETEQFFSNLKMPEGERGIRTGLELLKAYSRLK" gene 11085..11435 /gene="" /locus_tag="" /db_xref="2785994..2786344" CDS 11085..11435 /gene="" /product="hypothetical protein" /translation="MDKYKLALLGEAGAAGLDRGFSIRYKVFYESYLNEVSHWKYFQK YSRSFLEKPVYYAFSILGFVISLFGIEAVKKVNEIVERNAIDFYKINFNESNEDIKRI LEDEEKHFSMSVDA" gene 11464..12294 /gene="" /locus_tag="" /db_xref="2786373..2787203" CDS 11464..12294 /gene="" /product="xylose isomerase" /translation="MVKIYLGPAGIPHSSKKKNTIEGIRTVKELGLNAMEVEFVQGVR MSRETAEETGQVAKELGVRLSVHAPYFINLCSEEKDKIDASKQRILDTADRAELMGAD AIAIHIAFYGKMSPEECYQNVKEGLAEVIDKAKEMGIKNVKFGVETMAKETAFGTLDE VISISKELKGVIPYIDWAHTFARQGGEIDYGKIIDRLIKELGLTHINSHFESLVSRKG KYVDEHIPIDANAPPFEPLAKELLKRDISITLICESPELERDALKMKEVLERLGYRLE" gene 12275..12976 /gene="" /locus_tag="" /db_xref="2787184..2787885" CDS 12275..12976 /gene="" /product="SPP-like hydrolase" /translation="LDIDWNEILVASDYDRTLANEESNFVISPIVVQKINEFSKKYKF VVVSGREKKFMDKLAVGLRPTAWILENGSLIFFDNKEFVLCEKSWFERDREKIIEILD NLKAKYSIGRVIIYIDGYGSKLDMLRDIEKYGRIEVNRNDAMILPKGVDKGVGVLKFK ELTGFKGKIIAVGDSENDYALFRIADIKVAVANAIPQIKEIADIVTEKPNGLGVVEIL DKILSGNFGKEVDIH" gene complement(12938..13321) /gene="" /locus_tag="" /db_xref="2787847..2788230" CDS complement(12938..13321) /gene="" /product="" /translation="VEIDLESLETARNIKSELNLDIELLNADIIQFYGRFDTVIQNPP FGVVNRGIDIKFLQTAFSISNVVYSIHKSNERSRQIIIKIAKEHGFSAEILSERYRLK PYYPWHMKRIHEFLVDIYFFSKIPR" gene complement(13516..14184) /gene="" /locus_tag="" /db_xref="2788425..2789093" CDS complement(13516..14184) /gene="" /product="HAD-superfamily hydrolase, subfamily IA, variant1" /translation="MKAIFVDLGETLVHFKPRYHENIAYALKEIGYNVDEKRVFKAVA KILGKHHYPSPEYGGLSAFDFRELFYELNIYPDQESIARLNSKNLLSGEYELYDDSIT FLEEAKQLGFKVVLVSNATRNIYKIVEDLGIKKYFDGIVASCDLNVMKPHPKIFSYAM EIAKSDGIHIGDIYEIDVIGAKRAGLEAILLDRLGFYPEIKENRVNNLLEALELVKER LKNS" gene complement(14196..14501) /gene="" /locus_tag="" /db_xref="2789105..2789410" CDS complement(14196..14501) /gene="" /product="hypothetical protein" /translation="LNTDFLTTREKIFFLLSYLDEPLSAREIMRRLDIRKEKEIYDHI EHLARSSKRKGYTLIIIPARCKSCGYTFNSEKIKRPSRCPVCKSEKIEMPKFLIRNK" gene complement(14476..15243) /gene="" /locus_tag="" /db_xref="2789385..2790152" CDS complement(14476..15243) /gene="" /product="dTDP-4-dehydrorhamnose reductase" /translation="LKIAVTDEGEIAKAFARFLGSNSNEITIVDSPSKVIREKPDVIL HTFEIPIFESNMNPPLAWSFNTWYAINIARAGSKVGSVNVFLSSFLIYDGKRGFYKEH NTPNPLNYYGLTKLVGESSIITLGNYLVLRVGALFSLSYRGFLFPFIKASTRGKILKC NKNFYISIIDLNTLAKVSKLLINKEARGVINVGSNRVSLFEICSYLSDIFGNEVIEID NQQRDFSLDDWLLRAYNIKIDAKESILSLIEYRLLNN" gene complement(15328..18330) /gene="" /locus_tag="" /db_xref="2790237..2793239" CDS complement(15328..18330) /gene="" /product="FAD linked oxidase domain-containing protein" /translation="MGLEEELKSLLGDSFHDELVERLSHSVDFGFVPELVWSGIKINI VPDYVAYPRSVEDIINVVRLGLKYKIPIVPYGRGTNRYGNAIPADGGILLDFSKMTNV TIDESNKMAIVEPGATWKLVDIYAQQKGLQLRTFPSSYDSTVGGGIAGDALGIGSYEY GFISDNVSFVEMVNPKGDLVRLEGKDLALVCGAEGTTGIIAKAGLKLRNFSPTEAMII SFDNLDQMMHAVGEFYREVIPAWHVQVRGPYISTYMAEKYKAPFEPQKWNMVILYPSP RSPLVEPKIYKIAQSYGGKVFEGEWTGWWSFNHGVAAALRTQGLLIHQHGLIHYTKLL DLLKNLEKSIGKLGELSPDGGFDVDIALERREVLLVNAFTQISVSPVDKKILYDLAKN TLMMDEFVKVNGSLLSIGIFAHKYAKNRLSSMGKTFSDLGVDRYEVIRKYKEETDPNE IFNPGKLFDPKNRAKAILEIPRRQQEALNFRFAIGFVKRLSPGGEVEGFKHVRRYLED FADYSLMCIDCSMCVTVCPQYRLIPQWPYAPKGMFDFVRGAIAYYELNGSIDIPDSVI AEISGCHKCGLCDGVCPARIPISTLLIKLNSLVAKKLPEEPTVELSIFSDPELASVND PNSQFVLWVGKNAVSNPAVAITALKILKKMGLKVKVVGTSADSGFLDYISGNGNRFLE KMKQNLDTVNNSLEIITITPEDYRTFSTAYKDYSKLAGAEVFFEVVPLELRLLKSIVI DGSNENINLHVACFSSEYSDEVIKRLSEKGFRVKKIEGCSGAILEKSLGKRADLMARA IGERYGKVVTLCPLAAAKFRSVGINAVTLIEFLAEKLGIQSAQYRVVSFQLDENSKEY IKKELIASILSSLNSQVNLIADTASFSTSGVDEYKKIIEPIIVQVVDNIGKTIASKLS GSIRQKSSESSIDKAIVLAEYVKEISNTLSTIELDKVMQPFTSLLKSRVTEEYDENVV ISAIIQLLRDNTEKLKTIIVTEISKTLG" gene complement(18367..18786) /gene="" /locus_tag="" /db_xref="2793276..2793695" CDS complement(18367..18786) /gene="" /product="histidine triad (HIT) protein" /translation="MCIFCNIVEGRDHGYIVYSNDRVVAFLDKFPITPGHTLVVPRTH YENFLEISEDVIPYLCTAVRKISIAVKKALKADGIRILTNIGKSAGQVVFHSHFHIVP TWSQDPDIMKDFVPRKEQSREYYEYVQKAIIETLKNI" ORIGIN 1 tcaagtcgag attgcttcat tactaaccaa tactaatttt gccttagaca ttttaagtaa 61 ctcttttaga gtttctttaa actcctctag atgaacttca ggttgctcta taactataat 121 atcattattg cttgaatttt taatgaaata gactatagga aataagctta acacggaaga 181 gtccgcatta tatagtatat tatcatcaca gtaaacttca tcgtctttaa tgtagatttt 241 atgtgctaga acctcttcag aatacccttg tggtaagacc attgagttta tgaaatcaga 301 aattatgccg agcgtctttg gaatacccgg agctccctca aacctaatgg gaagaaattt 361 gtaaaatgat gctaccaatc cagccctaat tgctggtata atgtatggtc tcttcttatt 421 aatatctgaa aagtaaaagg agtctatctt aaccaaactc ctaatcttat cttcttgcag 481 ttctaactca ggtaaaactt tcaactctac tttagcttca accttaccat tttgaatagt 541 ccctatgata gacattttag gtgaggttat tttaaagtat aattctaatg ttaataactt 601 agctaaactt aactcatttg ttaaaatatg cgtgaattgt ctttcaaact cgtttttcca 661 atttacgagt ggttctttag ctgttattcc ataaagtcta ggaattaaga atatggtctt 721 agttagatag tagtaaactc tacctattac aattctatcc cttccgttaa ttatttcagt 781 ttgcttatta tcattattaa ttttaacagt agcagaagga gtttttatct ctatttccat 841 aagcgttatt tgaattttaa aaataaaaga gttttagaaa cttcttattt taaagacaca 901 tttatacaag gcgagataac tggtactaca atttttagtg ataaaaacta tctcataaaa 961 agagtgagtg tggcgttcag taataaacct ttcggccaaa cttcaagcat agtgtcaact 1021 aagattgcca cgtgggtcct ttcaacccac gtgacgattc ggggagaagg gtttctttaa 1081 ttatttgggc tcataaggct tattattata ccatacactc catataatcc tagccaactt 1141 tctagccaaa gcagtgtaga acttcttacc ttttaaccta tccctatgag actcataaaa 1201 cttcaacaat gttgggttcc tagaataatt cctccctgcc aagaagtaaa gcaaactaca 1261 caagtactta ttacccctct tcgaaatacc cttacttatt acagcttttc cactcctttc 1321 cacaactgga tctaaaccac aataagccac aaaggactct ggtttaggaa aacgcttaac 1381 atcaccaaca ataccaataa taataccagc tgcaagcctc ccaattcccg ggattgttaa 1441 taaaacgtga ttatccggta cttgttcctc gatcatcctc ctaacttctt tcaatttctc 1501 ttgcgtttct aggagtgttt ttgctaggac tttgatttct tcaactacta ttggtgtgta 1561 ttctagttgg tatagttctt cttgtgtaaa atctcctttt gcgagttttt ctaacctttc 1621 cttgcttatc ttgttgttgt cgcttactag gaatagtgtt ctctctaacc tgttcttgta 1681 ctttacttct atgtccttga gagagtgtcc agaatgcaaa taattcaata aatataatgt 1741 gatagaaaaa caatattata actagttgag aatagaagtc aattatatct ttcaatatga 1801 gggaagatta atattttatt gtaatataaa ataacttata gttgagaaaa aatgaatttc 1861 aaacataccc catattattc tagttaaccc tagcctaggg ttaactagag agtttgacaa 1921 attcctcttg cggaactttt gctaacacgg aagtgtaaat caaggaattg taaattattc 1981 caataacgta aacaaaaacc tcaaccatat ccttgttaat agcgtaaggt ctccaatacc 2041 tcttcaagaa aataccaaag aattcaacat aacgtctaaa actagaaaaa ccaattatcc 2101 aagttgaggg cattcccaag aaacccctat caacaacctt ataaccactc ataccaaaac 2161 caaccttatt atcgggaaag tttgcaaact caacttgaat tgcgtgaaga atcatggttg 2221 gggaaatagc atataaaacc ttgaagccga agaaactcct acccctcttc ttcgcaaact 2281 cacccttaaa tctacgatga atcttagccc tcatatagta gtaaattaag tttgctgctt 2341 ccctaaactt tccttgtctc aagttgagtt ctagcttttt ctttaatgtc tccttgtttc 2401 tctttccgaa gggtacttcg attatgttgg aatctattgc ccagagtttg ttaactttgc 2461 cgtataaggc actacttggc aagtagtttt ctagtttgct tagcttttcc tcaagttctt 2521 ttgcgtattc cttgaatgct ttctttattt ctcccctaag tttctttgcc cttctgtggt 2581 tttcggattt tgacttgcgt tctcctagaa accatcttac tacaatgtcc gtgtaatagt 2641 atgcttctac atctctgtag gagcattgcc atatcatcat gacgatgagt actctaagta 2701 tgtataggtc tagtgatgat agtgcttttg aggtgattag tatgtagtgc attttcaaaa 2761 gagttttatg ccttgatgat agtttatcat aggggaccgg gagattgtag tattctatcc 2821 aaggtttcat atctcccaat ccttgtacta cgtcttcccg gtccccttta agtattactc 2881 aagattttac tccaagtgaa aattcaaaat ttctcaagag tttatgcttt cttttgagtt 2941 attatctata aacttataca tagatttatt gaattattta cacttgggat gctctcttga 3001 ggaagaggta aagtgttacc atttccctca aggggttata ctcgtactcc tttgccttat 3061 caaccatgtt ttctattttt tcagcatcgt aaaaatccgt tttctttccc ctaaactctt 3121 ttctcttgat aacatgtttg ggcttacttg taatactttt attcctttct ccttgaagta 3181 ttgtgaaggc cttattgcgt aaactcccgt aggttctagg actattgtac aaggtttcat 3241 ttcaagtatc tcttcatatc cctctttgtt gttcttgtat tttctcaccc tccccctact 3301 agttattaaa taatcttttg atacgtctat tcctattacc cctacccctt tgtcacacct 3361 acatgcgtga attttatcat aatgttcagt ccgacggtag gggttagtca cgcccgtagc 3421 cgaagacttt gcttcagata gtgtctcgac catgtttccc cagccgagga gagtattact 3481 ctccccgact aataaaacct atataggaca tagtgtcgtc attaagctat ttatatttgt 3541 ataacgagta ttacttatgg gtaggaaggc tgtagttagg caagacgttt cttgcccctc 3601 ttgtggtagt cataatgttg ttaagtgcgg taggcctttg ggtaggcaga ggtatttgtg 3661 tagggattgc ggtaagtact tcttgggtga cgctacttac cattccaaga agttgaggga 3721 ggaggctttg aggttgtatg ctaatggtat gagtatgagg gccatatcca gggtgcttaa 3781 cgtacctcta ggtactgtgt tcacttggat taagcgttat ggtgggcaga agtacgagaa 3841 gcttgttgag ttgtggggga agactaaagg cttagttaag ggtagtgttg ttactaaggt 3901 tgtggatgag atgtgggctt acttgtacaa gaacactaga acattctata aatgaatttt 3961 tacttgttat gtgtacacga gattggagtt tacctcattt actctgtggg cgatagggat 4021 gagaatactt ttcgcaaggt taaaaagtat ttgttggatg agggtagatg ggtgagcgat 4081 gattataact tgtacttctg gttgaaagac cacacggtta tctcaccagt taacccgaac 4141 gagtcctttc attcctcact aagggatagc ttgtacgttt taagagggct actaaggcag 4201 taaataggag cattagtacc atgatgtact tcatagccct agtcttatgg gagaaaaagc 4261 taataccaga atttgtagct taatgacgac cctatgtcac actcaagcac tttggaagaa 4321 acatttatat agaactatta gttagattat attaggtatg aacatgatta ttaggagaaa 4381 gaacgcgaaa gcattgtccg gtgctgtaac tgcattaata ttagtaatag catcagtaat 4441 aatagcatta gtagttgtgg catttgcctt tggattattt ggagcatttg caggacaagg 4501 gacagtaaca caagtcggaa cagcaacact aaatgctggt actaaaagtc tgatagtcac 4561 tctgaagaat actggagcaa ctacacaagt tactggagtg attataaatg gaaacttagc 4621 tagtgtatca ggccaagtta ccataagtgc tggtgaaagt acatattcaa tcgcactaag 4681 tgtcagcact tctacattac aaaatctagt tggttctcct atttcgctga cattacaact 4741 ttctaatgga caaacagtaa cagtgagtgc aatagtaacg agctgaaaaa gaggagccag 4801 caagatgaaa agtttttttt taatattttt ccaattttgc aaaaattttt atcataattc 4861 atataaacat tattatttaa gcctttgcga atactagtat ttgtggaata cccatatttt 4921 gacttgaaga ctgctagaga attgttaccg tggcttaggg atcgcttaat acaattgaga 4981 aagataaaga atgagattga gatcctttta gttaatggtg ataaatatgc tttgcaacaa 5041 tacgctagtg agactaagaa aattattgac gaaatcattt caaagggtat tatactacga 5101 gacatagata taggcttagt tgacttccca gctattataa ataataagcc tgcatttctt 5161 tgttggaaaa tagacgaggg tgacataaag tattggcact atacggacga gggatttaga 5221 gggagaaaga ggttaactgg ttatgaggat attctaagtt tacgttaaat ttatttattt 5281 aattctctta acaattccct atgtacgttg gtgaaagagt aaaaagaaaa gaggatttaa 5341 agttcattac tggttctgga cgatacgttg acgacattga gtacccgggg acattatacc 5401 tttatattgt taggagtaac attacgcacg ctaaaattaa gaagattgac gttagtgacg 5461 ctttgaaagt aaatggtgtt attggtgtta tcactggttt gacaatccct tttgagaata 5521 gacctaggaa ttggccaatg gccaaggatg agatattata cgttggccat cctattgcag 5581 caattttggc tactgataaa tatacagcag ctgatgctgc agattcggtt caaatagact 5641 acgaggagtt acctgcagtt atcgatccag aaaaggcttt gaaagacgat gtaaaagcag 5701 ttgagggtaa aagtaatatt gcctataaga aggtttataa cgcgggtgat ccagataaag 5761 ccctttcaaa ctcagatatt atattggagg agaaactcga aatttcaagg gtttatccct 5821 cgccaatgga aactagagga ttgctttcag tatatcaaga gggtagtttg ttagtttacg 5881 catctactca atccgcccat tacatgagaa ggtatttatt gtcagccttt ggtaacatgg 5941 ttagggatat aagagttatt caagctgatg ttggaggtgc ttttggggct aagttattcc 6001 catatgctga ggatttcata actgtttacg ctagtttgca atacaagagg cccgtaaagt 6061 gggttgcttt aaggagtgag gatataaggg gtatgtacca tggtagggga cagatacaca 6121 aggttaagtt tggagctaaa aaggatggta ctttgactgc aatgatagac gatgcggtta 6181 ttgacttagg tgctgcttct catggaactt acttggtgga tatagcagct acaatgttga 6241 ctggaccgta taaggttagg gatctaaggg ttaatgctta tggcgtttac acgaataaga 6301 ctccgttgga tcaatatagg ggtgccggta ggccagaggc tgctttcgta tacgaaagga 6361 tcatggatat tatttctgat gagctgaaat tggatccaat ttacgttaga aaaaggaact 6421 taattactga attaccttat gttaatcctc ttggtctaaa gtatgattct ggtaattact 6481 taaagttact ggaaaaagcc gagaaagtct atagggagtt tgaggagaga gctaatgagt 6541 tgagaaaaca aggtagaaga attggtgctg gtttatcatt ttatctagag cagaataact 6601 ttggtccttg ggagagcgct tcagttagga ttaaggcgga tggtaaggtt caagttataa 6661 ttggtgcaag tccacatggc caaggtactg aaactggtat tgctcaaatc gttgccgatg 6721 aattagaaat aagtgttgat gatgttgaag tgatctgggg cgataccgct attataggtg 6781 agggttttgg tacttacggt agtaggagtt taaccttagc tggtaatgca gcattattag 6841 ctgctaggag ggtaaaggag aaggctttga ggttagctgc acaatttatg aagtcagatg 6901 ttcaagagct tgaatataag aacggtgagg ttattaatcc taagagtggt agaacaatga 6961 gtctgaagga aattgctact cgtaatatgg ctagcttagg tggtatttgg gagtacaagg 7021 aagaacccgg actggaagct agtggatatt tcggatttga taatctaact tatccctacg 7081 gttcacatgt ggttttaaca gaggttgatg attctggaaa ggttaagata ctagattatt 7141 atgctattga cgatataggt actgttgtaa atccaatgtt agctgaagct caagttatag 7201 gaggagtgat tcaaggcttt ggtgaaagta tttttgagga aattgtttac gacgagaatg 7261 gtaatttgct aactggtaat ttgtttgatt acgctattcc aacagctgtt gaggcattca 7321 atattaaatg ggagtacatg gaagagggaa agtctaatgc tcctttgcca gcaaagggaa 7381 ttggtgaggg agcgacaatc ggtactccac cggctcttat aagggcaata gagaaggcta 7441 ttggtaagag gttaactaga ttgccaagca aattagagaa tttaatataa aattctcctt 7501 ttttataaag taatttaaaa ttcttttgac agtagtatag atagaaagct atttaagtaa 7561 aaataaacac tgttaaagca gtatgactca agtaatagaa tcctattcct caccatttta 7621 taagaacata atcgatttac ctccatcaat ggttaggaaa ttatggaaaa gtggaaagat 7681 aataatactc gatattagaa caccacagga atatgaggac catcacatac cgggggcgat 7741 cttagcaccc ctagactatc tagaacattt aactgaactt ttcgaagata gggaagttgc 7801 agtagtttgt gaacacggaa atagggctag ttatgccaca tacggtatgc ctcatcttta 7861 caagaaaaag gcttactata tgattggtgg aatggcatta tggatggcaa tgggttacga 7921 agtggaaagt ggaatggacg aaaatggagt gttatggcaa aagattctag aaatgaaatt 7981 caactattaa caagctgagc ctccactgga acgtaaatag tattttggtt agttactatt 8041 actagagtca aagttactgt ttgtaaccca ttaggaaagg taaatccagt gttaatagta 8101 tatttatgtt ggcctatcga tagcgtatag tcaatgttat gcaaagttgt gctgtagatt 8161 atccctacta tcttagcatt gctaaaggaa ttttccaagg tgatgttgag tttaccatct 8221 tgtgttatga gagctgtacc tatttgtctt acttctccat agctgcttcc aaaatacccc 8281 agatatccga acaatataga aattactgtt atagctaaga ttactgaggc tagtatcact 8341 atcatcattg tcaaggaatc acttaaacct tttctcatat gtgttattta gttttcgatg 8401 aatataaatt agaccgtttt atatagattt tttgtactga tttttatata tagttatacg 8461 agtctagtga aaaaggttta tatagaatag atatcgttga tattctgcta caatgaagaa 8521 tacgaaacac caggtccttt agggtatagc aaataccgaa ctttaatcaa aactaagagg 8581 ttcatatatg tgaagagtcc tctgatcctc ctaaaaatac ccttgataac gagttttcaa 8641 gttaatagaa aacactttaa accttattat atcataaaaa cacatgatta aggttaatag 8701 atacgagatt tttcttgatt tcagctttca aactggagat tataagggat atgagaaaat 8761 tgaaatggaa agcgatgaag aaacagtagt actagacgct gtaggtttga agattttaaa 8821 agtaaaagta aacgaaaaag agattgaatt ctcacaagac gagagtaaag tcaacgtgaa 8881 aagtggatct ttttctggta ttttagagat agaatttgag ggaaaggttg ctgaaaggaa 8941 attggtgggt atttataagg cttcttataa agatggatac gttattagta cgcagtttga 9001 ggcaacacat gctagggact ttatcccttg ttttgatcat cctgcaatga aggccaagtt 9061 taagttaact gttagagttg ataaagggct taaggtaata tccaatatgc cagtagtaag 9121 agaaaaggaa aagaatggga aattagtata tgaatttgat gaaacgccta gaatgtctac 9181 ctatttacta tacctaggaa ttggaaactt tgaggaaatt aaagatgaag gtaagattcc 9241 aacaattata gtagccacaa taccaggcaa agtgcaaaag ggaagattct ctatgcagat 9301 ctcaagaaat tctatagagt tctatgggaa gtattttgaa atttcctacc aattgcctaa 9361 agttcattta atcgcaatac cggaattcgc atatggggct atggagaatt ggggggcaat 9421 tacttttagg gagactgctt tattggctga tgattcttct tctgtttatc agaagtttag 9481 ggttgctgag gttgttgctc atgagttagc tcaccaatgg tttggtaact tggtaacttt 9541 aaagtggtgg gacgatttat ggttaaacga gagtttcgca acattcatga gccataaggc 9601 tatttcgcaa ctattcccgt catggaactt ctggggttat ttcgttttaa accagacttc 9661 taaagcattg gagaaggact ctgtgtcaac tacgcaccca atagaggcac acgtaaagga 9721 ccctaatgaa gtagagcaaa tgtttgatga tattagttac ggtaaggggg ctagtatttt 9781 aaggatgatt gaggcttatg ttggtgagga gaatttcaga aggggtgtag ttaactactt 9841 aaagaagttc tcgtattcaa acgctcaagg ttctgattta tggaattcca tttctgaagt 9901 ttatggttct aatatttctc cgataatggc tgactggata actaaacctg gctatcccat 9961 ggttagggtt agtgtttctg gaaatcgcgt aaacttagag caggagagat tttcggtatt 10021 aggaaacgtt gagaacttga cttataagat tcctcttacc atggaggtta acggtaagat 10081 tgtaactcat ttactagaca aggagagaga gactataact tttgaggaag atataaagag 10141 ctttaaggct aacgtaaata ggactggatt ttatcgagtt ctttacaact cttatctagt 10201 gttcaatgcc aaattatcag agctcgacaa gtggggtatt ataaacgatt actgggcttt 10261 cctattggct ggtaaaatag actttaagga atatgaaagg ataatatcta aattctttaa 10321 tgacaaagat ttcttaccgg ttaatgagct ttctaatgaa ttatttaccc tttatgcgat 10381 aaatccggac aagtatcaag gtatttcaaa ggaatttcat agaattcagc tgaagaattg 10441 gagaaattca aaggatgagt taggaagact gacgtattca aatattcttt atagacttgc 10501 tgcaatggat gatgagttct ctttaggtct ttctgagatg ttcagattct acgattctct 10561 agattctgat acgagacaag gagtagctgt ggcatatgct attacttatg aagaggacgc 10621 tattgacgaa ctgttagaga gatataggaa ggaaagcttt gatgaggaaa aacttagata 10681 tctaaccagc atgttattct ttaggaagcc ttatcttgtg ggaaacactt taagtttaat 10741 actgagcggt gagattaaga agcaagatat tccttataca ttaagcgtag tatcttacaa 10801 cccttatgct aagagtgcag tgctaagttg gattaagatg catgtcaact tcatgagaga 10861 ggcctataag gggactggga tacttgggag gagacttgca gaagttattc cactaattgg 10921 aataggggca gaaaaagaaa ctgagcagtt ctttagtaat cttaaaatgc cagaaggaga 10981 gagaggaata agaacagggt tggagttact taaagcttat tcgaggttaa agtgataaag 11041 attttttaac atgtaccttt taccctttct aaatattata tatcatggat aagtacaaat 11101 tagctttatt aggtgaagct ggtgcggccg gattagatag aggattttcg attagatata 11161 aggtttttta cgagtcttat ctgaacgagg tatctcactg gaagtatttt caaaaatata 11221 gtagatcgtt cttggagaaa cccgtatatt acgctttttc aatccttggt tttgtgattt 11281 cactatttgg aatagaggct gttaaaaagg ttaatgagat cgtagaaaga aacgccattg 11341 atttttacaa gattaacttt aatgagagta atgaagatat aaagagaatt ctggaggatg 11401 aggaaaagca cttctctatg tcagttgatg cttaaataag ttttgcataa gaagattaaa 11461 ttaatggtaa agatttactt aggtcctgcg ggaattccgc actcctctaa aaagaagaat 11521 acgattgagg gtataaggac tgttaaagag ttaggcttaa acgctatgga agttgagttc 11581 gtgcaaggtg taagaatgag cagggaaact gcagaggaaa ctggacaagt tgctaaggaa 11641 ttgggagtta ggttatcggt tcacgctcca tatttcatca atttgtgttc cgaggaaaaa 11701 gacaaaattg atgcttcgaa gcagagaatt ttagatacag ctgacagggc tgagttaatg 11761 ggagctgatg ctatagctat tcatattgca ttctacggta aaatgagccc agaagaatgt 11821 tatcaaaacg ttaaggaagg attagcagag gtaatagata aggctaagga aatgggtata 11881 aagaacgtta agtttggtgt tgaaactatg gctaaggaaa ctgcttttgg gactttagat 11941 gaagtcatct cgatatctaa agagctaaag ggcgtaatac cctacataga ttgggctcat 12001 acttttgcta ggcaaggtgg ggaaatagat tatgggaaga ttatcgatag gctaattaag 12061 gaattaggtt tgactcatat aaattctcac ttcgaatctc tagtttctag gaaaggaaaa 12121 tatgtggatg agcatattcc catagatgct aacgccccac cgtttgaacc attagctaag 12181 gaattgctta aaagggatat ttcgataaca ttgatatgtg aaagtccaga attggaaaga 12241 gatgcgttaa aaatgaagga ggtattggag agacttggat atagactgga atgaaatact 12301 agtagcttcg gattatgata ggacattagc caatgaagag agtaattttg taatatcccc 12361 cattgttgta caaaagataa atgaattttc aaaaaagtat aagtttgttg tagtgagtgg 12421 tagggaaaag aaatttatgg acaagttggc tgttggttta agacctactg cgtggatact 12481 ggagaatggt tcgttgatat ttttcgataa taaagagttt gtgctttgtg aaaagagttg 12541 gtttgaaaga gatagggaga agataattga aatattagat aatcttaaag ctaagtattc 12601 tataggtaga gttataatat atattgatgg ttatggatct aaattagata tgctaaggga 12661 tatagaaaag tatggaagaa tagaggtgaa tagaaacgat gctatgattc tacctaaagg 12721 tgtggacaag ggtgtaggag ttttgaagtt taaggaatta actggattta agggaaagat 12781 aatagctgta ggagatagtg aaaacgatta tgcgttattt agaattgctg acattaaagt 12841 agcagttgca aatgcaatac ctcaaataaa ggaaattgct gatatagtga ctgaaaaacc 12901 taatggttta ggagtagtgg agattttaga taagatatta tctgggaatt ttggaaaaga 12961 agtagatatc cactaagaac tcatgaattc ttttcatgtg ccaaggataa tatggtttta 13021 atctgtacct ctcagacaat atttcagcag aaaatccgtg ctctttagct attttgatta 13081 taatttgcct cgatctttca ttagacttat gtatagagta gactacattg gaaatactaa 13141 aagctgtttg taaaaactta atatctattc ctctatttac tactccaaat ggaggatttt 13201 gaattacagt atcaaatcta ccgtaaaatt ggattatatc agcatttaac agctctatgt 13261 ctaagtttaa ttcgcttttg atatttcttg cagtctctaa tgattctaga tcaatctcca 13321 cacaagtgca ataagcacct aaaagtgaag ccgcaaagca gaaaacgcca gttccacaac 13381 ctaaatcaac taccttctta ttgcttatat gcccagatat atatgcgtgc caaactattt 13441 gagcaactat tggtgaaggt gttacatact gttctagttc gtacttcgga tttggatgtg 13501 gttttgaata tttttctagg aatttttcaa tctctctttt actaattcta gagcttccaa 13561 taaattattc accctatttt cctttatttc aggatagaac cctaatctat ctaaaagtat 13621 tgcctcaaga cctgctcttt tcgcaccaat tacgtctatt tcgtaaatgt cgcctatatg 13681 aataccatca cttttagcga tttccatggc gtaggagaaa atctttgggt gaggtttcat 13741 aacgttcaaa tcacatgatg ctactatacc atcaaagtac ttcttaatac ccagatcttc 13801 tactatttta tagatatttc tggttgcgtt actaactaaa acaactttaa atccgagttg 13861 tttggcttcc tctaggaacg taattgaatc gtcatagagt tcatattccc cagataacaa 13921 gtttttgcta tttaatctag ctattgattc ttgatcagga tatatattaa gttcataaaa 13981 cagttcccta aaatcaaaag ctgaaagacc tccgtattct gggctaggat agtgatgttt 14041 tcctagaatc ttcgcaactg ccttgaaaac tctcttttcg tcaacattat acccaatttc 14101 cttaagggca tatgcaatat tttcgtggta cctaggctta aagtgtacta gcgtctctcc 14161 taagtctaca aatattgcct tcatatatat tcgctttact tgttcctaat taaaaatttt 14221 ggcatttcaa ttttctcaga cttgcaaact gggcatctac taggcctttt tattttctca 14281 gagttgaatg tgtagccgca actcttgcac ctagccggta ttattataag cgtataacct 14341 ttccttttgc tcgaccttgc caaatgctct atatgatcgt aaatctcttt ttccttccta 14401 atatctagtc ttctcattat ctccctagca ctcaacggtt catctaaata agataacaag 14461 aaaaatattt tttccctagt tgttaagaag tctgtattca attaagctca atatactctc 14521 ttttgcgtca attttaatat tatatgctct cagtagccaa tcatctagag aaaaatccct 14581 ctgttgatta tcaatttcaa taacttcatt tccaaagata tctgaaagat aactacatat 14641 ttcaaaaaga gatactctgt tacttcctac gtttattaca cccctagcct ctttattaat 14701 aagtaattta cttaccttag ctagcgtatt caaatcaata atagatatat aaaagttttt 14761 attacatttc aagatttttc cccttgtaga agctttaata aatggaaata gaaaacccct 14821 atatgatagt gaaaataacg ctccaactct taaaaccaag taattaccta aagtgataat 14881 actactttct ccaactagtt tggttaatcc atagtaattc aatggattag gagtattatg 14941 ctctttgtaa aaacctctct ttccatcata aattagaaaa gaagaaagaa atacatttac 15001 gcttcctacc ttagaaccag ctctagctat gttaatagca taccacgtgt taaatgacca 15061 agctaagggg ggattcatgt tactttcaaa aattggtatt tcaaaggtgt gcaatatcac 15121 atctggtttt tctcttataa ccttagaagg actatccact attgtaatct cattactatt 15181 actaccaaga aatctggcaa aggctttagc aatctctcct tcatctgtaa ctgcaatttt 15241 caatatctat atcctctctg atctagaatt aaaaaagttt cgatgattat atagtgttgg 15301 tcaggattat tttaaaaaaa ggcaaatcta acccaaggtt ttgcttatct cagtcacaat 15361 tatagttttt aatttttcag tattatccct tagtaactgt atgattgcgg atatcactac 15421 gttctcatca tattcttctg tgaccctact tttcaataac gaagtaaagg gttgcataac 15481 tttatctaat tcaatagttg ataatgtatt ggatatttct tttacatact ccgctagtac 15541 gattgcttta tctattgaag actcagagga tttttgcctt atactaccag atagtttaga 15601 tgcgatagtt ttgcctatat tatccactac ttgaactata ataggttcaa taatcttctt 15661 atactcgtca acaccagaag tggaaaatga tgctgtatca gctattaggt tgacttgaga 15721 attaagagat gatagtatac tcgcaattag ctctttcttt atgtattctt tactattctc 15781 atctagttgg aaagaaacta ctcgatattg tgcactttgt attcctaatt tttctgctaa 15841 gaattctatt agtgttacag catttattcc tacacttctg aacttagcag cagctaatgg 15901 acatagtgta actacttttc catatctttc tcctatagct ctagccatta agtcagctct 15961 cttccctaaa ctcttttcta ggattgcacc agaacaacct tcaatcttct taactctaaa 16021 tcccttttcg cttaatcttt taattacctc atctgaatac tcagaggaga aacaagctac 16081 atgcaagttt atattctcat tacttccgtc aataacaata gactttaata gcctaagctc 16141 taatggcact acttcgaaaa atacttctgc tccagccaat ttagagtagt ccttatatgc 16201 tgtggagaat gttctgtaat cttcaggagt aatagtaatt atttctaatg agttgttaac 16261 tgtatctaaa ttttgtttca ttttttctaa gaatctattc ccatttccac ttatataatc 16321 tagaaatcca ctatctgctg atgtgcctac tactttaact tttaatccca tctttttaag 16381 tatttttaac gcagtgatgg ctactgcagg attacttaca gcattcttgc caacccataa 16441 cacgaattga ctatttggat catttactga ggccaactct ggatcagaaa agatggatag 16501 ttctactgtt ggttcctctg gtaatttctt agcaactaga ctgttcaatt tgatcaatag 16561 tgttgaaatt ggaattcgtg ctggacatac tccatcacaa agaccacatt tatgacagcc 16621 tgaaatctca gctattacac tatccggtat gtcaatggaa ccgtttaatt cgtaataagc 16681 tattgcaccc ctaacgaaat caaacatacc ctttggagca taaggccatt ggggaattag 16741 cctatattgt gggcaaacag taacacacat tgagcaatct atacacataa ggctataatc 16801 agcgaaatct tccaaatacc ttctcacatg cttgaaaccc tcaacctcgc caccgggaga 16861 caatctttta acaaagccaa tcgcaaacct aaagtttaag gcctcctgct gccttcttgg 16921 aatttctaga atagccttag ccctattctt aggatcaaaa agcttgccgg gattaaaaat 16981 ttcattcgga tcagtctctt ccttatactt ccttataact tcatatctat cgactcctag 17041 atcactaaat gttttcccca tactgcttaa tctattttta gcatatttgt gagcaaagat 17101 acctattgat aaaagggaac cattaacttt tacgaattcg tccatcatta atgtgttctt 17161 agctaaatca tacaatatct tcttatcaac tggacttact gaaatttgag taaatgcatt 17221 aactaaaagg acctcccttc tctctaaagc tatatctaca tcaaatccac catcagggga 17281 tagctcacct aatttgccta tagacttttc tagattcttt aataaatcta aaagcttagt 17341 ataatgtatt aggccatgtt gatgtatcag tagcccttgt gttcttaatg ctgctgcaac 17401 gccatgatta aatgaccacc aaccagtcca ttctccttca aaaactttgc cgccataaga 17461 ttgagcgatc ttatagattt tcggttcgac tagaggtgat ctaggagatg ggtatagtat 17521 taccatattc catttttgag gttcgaatgg tgccttatac ttctcagcca tatatgtgga 17581 aatatatgga cccctaactt gaacgtgcca agctggaatt acttccctat aaaactctcc 17641 cactgcatgc atcatctgat ccaaattatc gaaggatata atcatagctt cagttggaga 17701 gaaattccta agctttaacc cagctttagc tattatcccg gtagtacctt ccgctccaca 17761 tactaacgct aaatccttgc cctctagtct aactaagtcc ccttttggat ttaccatttc 17821 aacgaagctt acattgtctg aaataaaacc atattcatat gaacctattc ctaaagcgtc 17881 tccagctatc cctcctccca cagtggaatc gtatgaagat gggaaggtcc ttaattgcag 17941 tcccttctgc tgagcataga tatcaacaag cttccaggta gcaccgggct caactattgc 18001 catcttattc gattcatcta tagttacgtt ggtcatcttt gaaaagtcaa gtaatattcc 18061 accatctgct ggtattgcgt taccatatct atttgtacct ctgccataag ggactattgg 18121 tattttatat ttgagtccta atctaactac gttaataata tcttccaccg acctaggata 18181 agcaacgtag tctgggacaa tgttaatctt tattccagac cacactagtt ctggaacgaa 18241 accgaaatcc actgaatgag atagtctctc tactaattca tcatgaaaac tatcccctag 18301 taaacttttc aactcctctt ccaaacccat attactaccc ttaaatgtta tatattattc 18361 tagcatttat atattcttta aagtttctat tattgctttt tgtacgtact cgtaatattc 18421 ccttgactgt tcttttcttg gtacgaaatc tttcattata tctggatctt gggaccatgt 18481 tggaactata tgaaaatgag agtgaaatac cacttgccct gcactctttc caatattggt 18541 taatattctt ataccatcag ccttcaaagc tttctttact gcaattgaaa tctttcttac 18601 agctgtacat aaatatggta tgacgtcttc agaaatctct aaaaaattct cataatgtgt 18661 tctaggtact accaaagtat gtccaggtgt aataggaaat ttatccagaa atgcgactac 18721 tctatcgtta ctatacacga tatacccatg atcccttcct tcaacaatgt tgcaaaagat 18781 acacat //