LOCUS NC_012622:22 18703 bp DNA linear BCT 04-SEP-2013 DEFINITION Sulfolobus islandicus Y.G.57.14 chromosome, complete genome. ACCESSION NC_012622 SOURCE Sulfolobus islandicus Y.G.57.14 chromosome, complete genome. COMMENT locus start: 2319598; locus end: 2338300 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.728399; n0_4mer:D = 18.385214; n0_4mer:PS = 31.727372 FEATURES Location/Qualifiers source 1..18703 /organism="Sulfolobus islandicus Y.G.57.14 chromosome, complete genome." gene 1..1104 /gene="" /locus_tag="" /db_xref="2319598..2320701" CDS 1..1104 /gene="" /product="FAD-dependent pyridine nucleotide-disulfide oxidoreductase" /translation="MKRLVVVGGGNAGTLIANLLAGKLEITVIEPNEYHTYQPGLVDY ITGEVDETKIQMPTRLLLKPSVKWVRAKATKIIPEDRAVVAEDGKTYEGDYLVIAIGG QNKDIYNLKGYHGIDDSKVIRNEVLNPRGKNFVIGSLPGIIKCPAAPWELSFLIKRKY PDANVSVIVPAKQPPPLQVPMSNMFNKKANELGIKVYKGFVIEEVNHNERYVVSTEGD KISFDHLIIDTPISTNFPEFADKSGLIPVDKSTLVYRDGVFVVGDANNTPTPKTGAAA HFQAEVVVNNILAEIEGNRSKESYDGTAMCAVYSGPNEGMLVWLNYEKSKALGPTSIY RYMKKAFTSLYWASLSGGVDFVLKPLVESVRKN" gene complement(1101..1430) /gene="" /locus_tag="" /db_xref="2320698..2321027" CDS complement(1101..1430) /gene="" /product="Rieske (2Fe-2S) domain-containing protein" /translation="MVWKRTISAKALEKAKSAAVKVEDKVVFIANIKGVLYAMDAVCS HARCILGQLDEEKLTVKCYCHHALFDLRSGQMLEPPYVAPDAPKEKLGLKTYQIRDNG GWIEVDI" gene complement(1516..2319) /gene="" /locus_tag="" /db_xref="2321113..2321916" CDS complement(1516..2319) /gene="" /product="beta-lactamase domain-containing protein" /translation="MPCRGLHAIPAGPPEFPELATVYVICGEKLNVMIDAGVTNSIMD SSFLDKLDLVILTHIHIDHIGLLPEILDRYKNVKVMVRSGFKKFLTTDDGVKRLNESS EKVLGDLYYIYGEFTKIDPDKVVEVEGGEMIDLGDGKTLKVIYTPGHAKHHISVISED ILFTGDSGGAYFNGIVIPTTPPPLDYDNYVNSLRLQISLKPKVVGLAHGGLVSPNVLE QHLEQMLGKESLNISEEIDIGGIGGEILRKQVEVNLRGLNEALERRRKI" gene complement(2782..3731) /gene="" /locus_tag="" /db_xref="2322379..2323328" gene complement(3955..4521) /gene="" /locus_tag="" /db_xref="2323552..2324118" CDS complement(3955..4521) /gene="" /product="hypothetical protein" /translation="MEREIIRILSVIEFHPLIMAFHLGLMLVGVSLLSYSVFSIIIKK VDIMFQLLTGFMVYLMSLILLILILLLETYRFLIVNGKILVKNSLLRKNRFEFNLKDK NLIIGFYDKPFLAKFAIIYGDRLLFKFLTRQKNIALIKNFVLKSSYRMGGTYKICSFC GSINEENAEYCDFCGSRELSPYDLYWID" gene 4615..5529 /gene="" /locus_tag="" /db_xref="2324212..2325126" CDS 4615..5529 /gene="" /product="aldo/keto reductase" /translation="MEKKTLGWTNEKISPLILGSWEFGTPSIVDETNAIKVIQKSIEL GINAIDTAESYGNGLSETIIGRAIGKFKREDLFIITKVSIDHLRYDDVLRACEGSLRR LNTSYIDLYLVHWPNHYVPIRETAKAMERLFNEGKIRYIGLSNFSLPLLREFREHLSK TDVAANELHYNVLFREVEKEILPYMLRENIPLLAYDALGLGYLIGRKEIRNEYKWYVL AREAYVKNLEPLVDEISSIAKEIDRTPAQIILNWLVSKDNVFAIFNTTKEDHLRENLG SLEWSLRDSDLKRLDEAVKKVVIDYFIR" gene 5588..6025 /gene="" /locus_tag="" /db_xref="2325185..2325622" CDS 5588..6025 /gene="" /product="Carboxymuconolactone decarboxylase" /translation="MGSLFDKDPELKRLYDKGLEVRKKVMGKEYVERSLSQATDFNRE LQEMVTIFAWGLIWTREDIIPRKIKSLINIGILSALNRQNELKLHIKGAIRNGCTEEE IKEVLLQVGVYCGLPAAMESFRIAQEAIKELEDEEKSEKHKDN" gene 5991..6422 /gene="" /locus_tag="" /db_xref="2325588..2326019" CDS 5991..6422 /gene="" /product="hypothetical protein" /translation="MRRKVKNIKIISKDKRIEVSVSMDLIIEKNGIVPFTKGDPKYFT GNVIVKQVHDSEEPSRVTASVVTFEPDARINWHYHPLGQLLIGIYGTGLIQTWRSPPR KIKAGDVIRRCNMDSARCEALAWCYCNNYNDPYSYSRKNKR" gene 6057..6489 /gene="" /locus_tag="" /db_xref="2325654..2326086" gene complement(6791..7384) /gene="" /locus_tag="" /db_xref="2326388..2326981" CDS complement(6791..7384) /gene="" /product="" /translation="MSRLADYLPSSALYGKVGKLWIVDSFLIEVPFGKRNKETLKKKF ELDLRQRKYREAANTLFFYIKCKVRRRFKGEFTKKRDRSYFGFKVFNLMSPTMIVHEI QVELANFPDNKVGFSRSGYKVVDRGFVGKSSTWLIGFSSFRRYVEFFGIFLRRYWRPY ATEKGMVELFVYVIALIYNSYIYTSVLSRVPESQLAH" gene 7497..8735 /gene="" /locus_tag="" /db_xref="2327094..2328332" CDS 7497..8735 /gene="" /product="transposase mutator type" /translation="MTKSKNNPGRGNTIRESNTMKVMEEIREKIRKAIKEGVSLREIE EIILQEAMMEEREAYLEVEDDHKNGTYFRYLGTGDGVLRLRVPRTRKGGFRPKILPEK YERTSPDYEDFLQQLVLSGMTPSQVKAVLAAKGIPYSEIVMNRVAERISNKLKEYKSR ELPHDLLALYIDVKIVKVRISESIMERAIYIAIGVDLEGNKFVLDYEVRDREDLDGWK SFLSGLVSRGVSRVDVIVSDDFSGLDRVVSTLFPSSQHQLCITHMVRNLMRVLPDKEE LMIRVRDLKSSRNVEEGRKAILSLSQLVQPFSPARAKRLLDAADKYCSFLNFPREIRH YLYTNNTSESFNSTLARFEEELGGYFPSLRSLEVYLYVSIHESNSRWKFRPMSVIRHY SYHLKQLHASRFQVSLDEDF" gene complement(8764..9048) /gene="" /locus_tag="" /db_xref="2328361..2328645" CDS complement(8764..9048) /gene="" /product="transposase ISC1290" /translation="MKHWIEYYNGPVPYEHLSARHKTLVKMNYMLITSEVLSRLSDLF ILRALIVMIVWTCSYRDVRSYYESDVVVRWFLGEYKSKSEIHRRARGYWV" gene complement(9413..10357) /gene="" /locus_tag="" /db_xref="2329010..2329954" CDS complement(9413..10357) /gene="" /product="transposase IS116/IS110/IS902 family protein" /translation="LEAPVAGIDVSKDKLIMYFQGKLYEFPNDRQGFEEIRKILPKGC KVGIESTGVYHVNLAKYLNNEYDVRIINPFILKKFKDFRGKKSDKNDAKKLAELVVSM GSGFTTSDARELTSQWDFVTRSIARVKNRLRRDLVLLGYRDSLSKKNLEEVLRGGDSV VLSEVRFLLEELERLKTRKREIEKELENVVSKDSLIFTIPGIGKTLGCIILARVGDVR RFSDKKRFVAYCGLVVESSGKSVVSRGISKKGDAVLRRAFYLAALTAIKVNPVIKRFY EEHKGRLKGKKLITACARKLAVITWAVLYYNKPFDASE" gene complement(10691..10840) /gene="" /locus_tag="" /db_xref="2330288..2330437" CDS complement(10691..10840) /gene="" /product="hypothetical protein" /translation="MPQQNTERVGLENVRKGAIYFLVYSILNIIASAGVFSNTIVSIP FTFNN" gene 11039..11842 /gene="" /locus_tag="" /db_xref="2330636..2331439" CDS 11039..11842 /gene="" /product="hypothetical protein" /translation="MSSCEIFPLISKLSAEGKRFAIVSIYKGNRLERTLVSDGKVLLG SLDKEVIGLALEALEKGEVIQKDVEDGKLVIEPVEPRPAIIVVGSGIIAKFIAKLAVD MGYYVAVVGSGDVKEEDFVGVYAISNDLNLLEQMVSEDSFVIVANEGGKPYDIDALYI AMKKKARFVGLLASQKRAALMISLLIKRNIPLEEIKKRLHSPLGLDIGSKTSEEIALS ILSEVVLELRGGTGKRLQEVKNPYLLLDDALAGKIEDKCMFVPKSLSQQ" gene 11874..12806 /gene="" /locus_tag="" /db_xref="2331471..2332403" CDS 11874..12806 /gene="" /product="alcohol dehydrogenase GroES domain-containing protein" /translation="MKAAILTQFNSPFVIGNAEPKGVGVKVNVAYAGICGRDLVIWKG GFKNLKLPLILGHEIVGYYKGRPVAIYPNLNCGSCEYCKSGKENLCDNARILGEGEIT GGYAEEVIIPERNIIPLPDDKLEKYAATMDPVATAIHATKLANLNRDSKVLVTGAGGG VGIHLVQYLKYLGISSVYGLSSKGEKLQELGVTPISDIRSEKFDTIFELVGSKTINDS LRALKKEGTLVLIGNTEGEPITLLRPAMTIMRQQKIIGSASYTKAEYEEAIRLVGEGK IKAIYEIYELERINEAYRKMMERKVLGRAVLKVI" gene 12990..14192 /gene="" /locus_tag="" /db_xref="2332587..2333789" CDS 12990..14192 /gene="" /product="acyl-CoA dehydrogenase" /translation="MVLPFNSVEAFSVNVSEKHELFRRAVREFMERDVAPYVEKGEKE GTVPKEVLEKAKEIGLYGVAVPEQYGGQGGDTLMTAIAQEEISRVWASLSTRISVGGL FMTPILLFGNEEQKKKYVTPVARGDKVAAFANTEPAAGSDVAGIQTIAKKINGKYVIN GRKIFITNGGIADYYVVTARTSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRA SNTAELAFEDVEVPAENLLGEEGNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTY STQRFAFQSPLIGFQMVQEKIAESLTEVNTARLLTYWAASLFDRGLENEAIVAASMAK LYATDIAEKVAIRAITVHGGYGVATSTGVERLLRDVEVMRIYEGANDIQKLVILRETA RRLLGIKM" gene 14227..15840 /gene="" /locus_tag="" /db_xref="2333824..2335437" CDS 14227..15840 /gene="" /product="AMP-dependent synthetase and ligase" /translation="MNSEYYESQLTIDKILDSGSRSFPDREIVYRDIRRYTFRSFANS VKRLANGLRKIGVKKGEKIGVIDWDTDVYMHNYYAIPMLGAVLHTVNIRYPLELIAKT ILHAEDRYLVVRDEFMPLIEKAKGIMPVGMKVISYSDSKEKVRSPLDTIDFWELIESN EPLEEEINVNESDMATIFYTSGTTGEPKGVWFNHRKIVLHAMSVSLVGARPPLSLTSN DVYMILVPMFHVHAWGYPYVTLIAGVKYVLPGKYDYSFILRLMDKENVTYSAMVPTIL YLLLTNPDAPKYLHVFKRWKVTIGGSALPEGLAKKAKELGITVIGGYGLSETCPVLSV GYYNSAIEGLDDNTKFMEQITAGAPIPLVQIKIVDPATGKEKETGKIGEIVVRAPWLT QEYYKDPEKTKALWKGGWLHTGDLAYMDQYGYIHIVDREKDAIKSGGEFIPSLLLENA ISLHPKVSQVAVVGIKDEKWGERPAAFIVPKEQVSEEEIRQFLLKLADEGKIQKWWIP DRFIFISSMPLTSTNKIDKKVLRDMTQTK" gene 15864..17051 /gene="" /locus_tag="" /db_xref="2335461..2336648" CDS 15864..17051 /gene="" /product="acetyl-CoA acetyltransferase" /translation="MRNVAIIGTGHTKFGVRTDVNLQELAWEAVKQALEEANIDQNEI QYFVVGNVGNWSSEELPAVIVGEYCNLTPKGTMRVEAACSTGSAAIRDAYLAIKSGEA DIALVVGVEQMHQAPNPQVVELIGRAGGYFWEFENFGLTFPGYYALHASAYMAKYGMK EEDLGKIAIKNHYYGAKNPYAQFQKEITMEEYLKSKPVAYPLKLLDSSPITDGAAAIV LASEEVAKKITDSPVWIVSQGVASGTANLSRRTDFTHIEAAHIAAQQAYKRARIEFDN AWKNFDVADVHDCFTIAEIMAYEDLGFAKRGEGYLLAREEQTYIGGKIPVNVDGGLKA KGHPIGATGVSMAVSITRQLLYRAHKGTQVEVRNGMGITHNVGGTGHYAYVTIYSTRR PST" gene 17048..17584 /gene="" /locus_tag="" /db_xref="2336645..2337181" CDS 17048..17584 /gene="" /product="hypothetical protein" /translation="MSLNEIRDKMQKEISQSLLMLDNAIKTTKLPIVNEQKTNNPLWI DVREIDLRYQIPVKRIFKFFEGLREGKILATKCPKCGSIYFPPQDDCPKCKISNLEWI EMPKEGEIVAYTVVNVKPPSFSHYQDYIVGIARMSNGVNVLGWVRAKEVRVGMKVKLE VIERKPEGYLTYELVPVG" gene 17591..18703 /gene="" /locus_tag="" /db_xref="2337188..2338300" CDS 17591..18703 /gene="" /product="3-hydroxybutyryl-CoA dehydrogenase" /translation="MIRNVLVVGAGTMGHGIAEVSAIAGYNVYLSDVSKDILNNAIQK VKWSLEKLYEKGNLKESVEDVLGRIKTIEGLSNELREIDISIEAIPEKLDLKRQLFSK LEELLPNNAILATNTSSLPITEIASAVKRQERVIGTHFFNPPVLMQLVEIIRGSKTSD DTVKQTYEFIKSLRKIPIMVKKDVPGFVVNRILLRIITTACMLVEKGICEYTAIDAVA RYKLGFPMGIFELVDYTGVDVNYYVSSAMMERGFKAYPCKTLEEMTKKGDLGVKSGKG FYTYPSNKYIKPNLPPQLAEKINPLYIIAPAISEANWMVKNGIASKEDIDLGVRLGLS FPKGIFDYKREFGRESVTKTLEDLRRISGMEEYLPE" ORIGIN 1 atgaaaagat tagtcgtagt aggaggggga aatgcaggaa cgttaatagc aaatctgtta 61 gcgggaaaat tagaaattac agtaatagag ccaaatgaat atcacactta tcaacctgga 121 ttagtggatt atattactgg ggaggtagat gagactaaaa tacaaatgcc tactagatta 181 ttattaaaac catctgtaaa atgggtaagg gctaaagcta ccaaaataat accagaagat 241 agggctgtag tagctgagga cggaaaaaca tatgagggcg attacttagt aatagcaatt 301 ggaggtcaaa ataaagacat atataactta aaaggctatc atggaattga tgactctaaa 361 gtaattagga atgaggtttt aaatccaaga ggaaaaaact tcgttattgg gtctcttccg 421 ggaataataa agtgtccagc tgcaccatgg gaattatcat ttttgataaa gagaaaatat 481 ccagatgcta atgtcagtgt aatagtccca gctaaacaac caccaccatt acaagttcca 541 atgtcaaaca tgtttaataa gaaggctaac gagttaggaa taaaagtata taaaggattt 601 gtgatagaag aagtgaacca taacgagaga tacgtggtat caactgaggg agataagatc 661 agttttgatc acttgattat agatacgcca atctcaacga attttccaga atttgcagat 721 aagtctggat taattccagt tgataagagc actttagttt atagggatgg cgtcttcgtg 781 gtcggtgatg ctaataatac cccgacacct aaaactggtg ctgctgccca ctttcaagct 841 gaggttgttg taaataatat actagctgag atagagggaa ataggagtaa agagagttac 901 gatggtactg caatgtgtgc agtttactct ggaccaaatg aaggtatgtt agtttggtta 961 aactacgaga agagcaaagc cttaggacct acatcaattt atcgttatat gaaaaaagcg 1021 ttcactagct tatattgggc cagtttaagc ggtggagtcg actttgtcct aaagccttta 1081 gtcgaatctg ttaggaagaa ttaaatatcc acttctatcc aaccgccatt atctcttatt 1141 tgatacgttt ttaatcctaa tttttccttt ggcgcatctg gggcaacata tggtggttct 1201 agcatttgac cactccttaa atcaaacaat gcatgatgac aataacactt tacagtaagt 1261 ttctcttcat ctagttgacc taaaatacac cttgcgtgtg aacacactgc atccatagcg 1321 tataacactc ccttaatatt agctataaaa acaactttat cttctacctt aactgctgca 1381 cttttcgctt tttctaaggc ttttgcggat atagttcttt tccagaccat aagtctaata 1441 taaagatata tcttatattc tttaatttga taaagtttaa atcgtcatta taaataaaaa 1501 taagtcataa gactatcata tttttctcct tctttctaaa gcctcattta ggcctctcaa 1561 gttgacctct acttgtttcc taagaatttc cccgcctata cctccaatat caatttcttc 1621 actaatattc aaactctctt tacccaacat ttgctctagg tgttgttcta atacgttagg 1681 acttacaagt ccaccatgag ctaagccaac caccttaggt tttaaggaaa tttgtaacct 1741 taaactatta acgtaattat cgtagtctaa tggtggggga gttgttggga tcacgatacc 1801 gttaaagtaa gctcccccac tatccccagt gaataaaata tcttcactta ttacggaaat 1861 gtggtgttta gcatggcctg gggtataaat taccttcaaa gtctttccat ctccaagatc 1921 aatcatctct ccaccctcaa cctcgaccac tttgtctgga tctatttttg tgaactcgcc 1981 gtaaatataa taaagatctc ccaatacttt ctctgagctc tcattcaatc tctttacccc 2041 atcgtcagtt gtcaaaaact ttttaaaacc acttcttacc ataactttaa cattcttata 2101 cctatctaaa atttctggta atagcccaat atgatctata tgaatgtgtg tcaatataac 2161 gagatcaagt ttgtctaaaa aagaggagtc cataattgaa tttgtaacac cagcgtctat 2221 cattacgtta agcttctccc cacaaattac gtaaactgtt gctagttcgg gaaactctgg 2281 aggaccagct ggtattgcgt gtaaacctct acaaggcata gttacactat gttaagtaag 2341 tttataacat tattgagcct ttgaaagtta taagtgccgt tattaactta taaattcaag 2401 gatgaccgtc ttgtcccaca agactaaggg caataaaata cttaattata tcctaaaata 2461 ctcgtaatat aaaaataaat taggttaacg gcaacattat gtttaaaagt gagtatttta 2521 tttcttatga atgacaccaa atatttcctt ttaaatcaat aaaagccata aatgaaaaat 2581 caatttataa atcacaatta gagaggaaat cctctaatat cacaaaaatc tagatagaat 2641 ccttcctttt agatatattt tatcatttat aagataatag taaagattta ttaatctgca 2701 attattatat ttaattcaac gattatggag gtaccgggag tgttctcatg cagtcatctt 2761 attcgatatt gaatagtaaa attatatcag attttcccta atattctgca ctcctctcaa 2821 gtaagcctcg ttcaagggag tcttctccct tgaataaatt actggataca tgacattaag 2881 taaggcaaga ctataatcaa ccattctctg actcctattg acagccctag tgtccctagc 2941 caacctagcc aaatgagccc tacagtaaga gttataactc tcaaccgtat aagtgtactt 3001 cttacttgca acgtgattgt caaggacttg ataaacagag taatcatcag tgtaattaac 3061 ctcactctta ggcagagaat tcaagagaaa actaaaagtc ttataatccc tatcacccgt 3121 agtaaagaag ggtaaaccat cagctaaggc attccaaatc cacaagttct ccctcttgga 3181 accatgccta accctaaggt aagtccaact ctcgtcaaat accgtgactt ttgcggtaaa 3241 gctttttagt tgctcttgta ggactaataa attaacgtat gccactattc cttttatctt 3301 tatcagactg taaactgtag ttaaaggttt tccctcaact ttagctattc ccctcatgct 3361 catcctattc aagtactcct tcaagatcct ctccttttgc tccctactca tcccatgact 3421 attagcatcg tagaaagtcc ttctgcagac attacacttg tactttgtct tacctcttga 3481 tgaaccattc ttgatcacct tgtccgactt acaagatgga cagtttggcc tatctccctc 3541 ctcttcctta cacccaattt cctagtgtag taataaattg ttgatggcgg tattccaagc 3601 ttagttattg gcactcccaa caagtatgca gctattgcca ttgagatcct ttctagatcg 3661 tgttttctag gcttaacctt taaattctct aaaatcaata ctattaattg tgtgagggtg 3721 acgagatcca tagtttagga ccccctatac aatctcgtca ccctcacaca agaagttttc 3781 tcacgaagac ttataatctt aacatatatt taatattttt actattcaat atcgaataag 3841 atgactgcat gagaacaccc ccggggtacc acctaaaggc gaagcttccc gttccctaat 3901 cccatttttg gtaaaaattt ctaaattttt cttgcttgtt ttactccttt ttatttagtc 3961 tatccagtag agatcgtaag gtgataattc tcttgagcca cagaaatcgc agtattctgc 4021 gttttcttca tttatgcttc cacaaaaact acaaatcttg taagttccac ccattctgta 4081 acttgacttt agaacaaaat tttttattaa tgctatattt ttttgtcgag ttaaaaattt 4141 aaaaagtaat ctatcaccat aaattattgc aaacttcgcg agaaaaggct tatcataaaa 4201 cccaattatt aaatttttat cctttagatt aaactcaaat ctattttttc tcaaaaggct 4261 attttttacc aagatttttc cattaacaat cagaaaacgg taagtttcta gaagtaaaat 4321 tagtataaga agtattaatg acataagata aaccatgaaa ccagttaata gttggaacat 4381 aatatctacc tttttgataa ttattgagaa cacggagtag ctgagcagag aaactcctac 4441 taacattaaa ccaagatgaa aagccatgat taaaggatgg aattcaatta cggataagat 4501 cctaattatc tccctctcca taagaattaa tgcgtactca aaattaaaag aaaattggtc 4561 taggctaaac tcaattgata aacatttaaa tatctaacaa tatcttactt attcatggaa 4621 aagaagacat taggatggac gaatgagaag atatctccac ttattttagg ttcttgggaa 4681 ttcggtaccc cttccatagt tgatgagacc aatgctataa aagttattca aaagtcaata 4741 gagctcggaa ttaacgccat tgacactgcc gaatcttatg gaaatggtct ctcagaaaca 4801 attattggaa gagccatagg caaattcaag agagaagatt tattcataat aactaaagta 4861 tcaattgacc acttaagata tgatgacgtt ttaagggctt gcgagggaag cttaagaagg 4921 cttaacactt catatataga cctatacctt gtccattggc ctaatcacta cgtgcccata 4981 agagaaactg ccaaggcaat ggaaaggcta tttaatgagg ggaaaattag atatattggt 5041 ctaagtaact tttcccttcc cttattgaga gaatttagag aacatttatc caagactgac 5101 gttgcggcga atgagttaca ctataacgtt ttattcagag aagttgagaa ggagattctc 5161 ccttacatgt taagggaaaa tattcccttg ttggcatatg acgctttagg actgggttat 5221 ctaataggga gaaaggagat cagaaatgag tacaagtggt acgttcttgc cagagaagct 5281 tacgttaaaa acttagaacc acttgtggat gaaatatctt caattgcgaa ggaaatagat 5341 agaactccag cacaaataat tctaaattgg ttagtcagta aggataacgt attcgcaatt 5401 ttcaacacaa caaaagagga tcaccttagg gagaatttgg gcagtctaga atggtcactg 5461 agagatagtg atttgaaaag attagatgaa gcggtaaaga aagtcgtgat agattatttc 5521 ataaggtaat ttaagccttt tttatttacc aaattacttt ttatcttaat atttaactga 5581 tatagatatg ggtagcctat ttgacaagga ccccgaacta aagagacttt atgacaaagg 5641 acttgaagtt aggaaaaagg tgatgggaaa ggaatacgtg gaaaggtcat taagtcaagc 5701 tacagacttt aatagggaac tccaagaaat ggtgacaatt ttcgcatggg ggctaatatg 5761 gactagagaa gatattattc caaggaagat aaaaagttta ataaatattg gaatactaag 5821 cgctctgaac aggcaaaatg aacttaaatt acacattaaa ggagcaataa ggaacggttg 5881 tactgaggag gagataaagg aggtactatt acaagtagga gtttattgtg gtctgcccgc 5941 agccatggag agcttcagaa tagcacaaga ggctattaag gaacttgaag atgaggagaa 6001 aagtgaaaaa cataaagata attagcaaag acaagaggat agaagttagt gttagtatgg 6061 atctaataat cgagaaaaac ggtatagttc ctttcactaa gggagatccg aaatacttca 6121 ctggaaacgt aattgttaaa caagtacacg attcggaaga accatccaga gttactgcca 6181 gtgtcgtaac atttgaacca gatgcaagaa taaattggca ctaccatcca ttaggacagt 6241 tattaatagg tatttacgga acgggattaa ttcaaacttg gcgaagtcct cccagaaaga 6301 taaaagcagg agatgtaatc aggagatgta atatggattc cgcccggtgt gaagcactgg 6361 catggtgcta ctgcaacaac tacaatgatc catatagcta ttcaagaaaa aataaacggt 6421 aaggcagtag agtggcttga aaaggttagt gataaggagt gcgaagaggt ccaatctgct 6481 tccgactgaa tttctcccca ccctgaaaag gtcgagggtt ccctcccaga gggttcatag 6541 ttcccaccat cgattcgggt ttacatctct catttggtgg gcagtcgaga gagtgtccca 6601 agcgcaaata attgaataaa tatagtatga tagaaaaaca attttataat taattaagaa 6661 taaaatataa ttatatcttt cagtataacg agagattaag cttatattgt aatggaaaat 6721 aatcaagtat agagaaaaac agaattttca acatagtcca cactaccttg atcaactctc 6781 gcggtacaag ttagtgggcg agttgactct ccggaacacg cgataacaca gaagtgtaga 6841 tgtaggagtt gtaaatcaac gcgataacgt agacaaagag ctcgaccata cccttttcag 6901 tagcgtaagg cctccaatac ctcctcaaga agatcccaaa gaactccaca tacctcctga 6961 aactagagaa acctatcaac caggtcgagg acttccccac gaagccccta tccactacct 7021 tataaccgct gcgagagaag ccaaccttat tgtccggaaa attggccagt tccacttgaa 7081 tctcgtgaac tatcattgtt ggcgacatga ggttgaagac cttgaagccg aagtaactcc 7141 tgtccctctt ctttgtaaac tctcccttga acctcctcct cactttgcac ttaatgtaaa 7201 agaagagcgt gttagccgcc tccctgtact tcctctgcct taggtctagc tcaaacttct 7261 tcttcaatgt ttccttgttc ctcttcccga agggtacctc gattaggaag gaatccacga 7321 tccacagctt tccaaccttt ccgtataacg cactgctagg taagtagtca gcaagtctac 7381 tcatcttccc ctccaactcc ttggcgtact ccttgaacag agtctttacc tctcccctaa 7441 atttctttgc cctcggggct accagttata gttgtggtag caaaaggtga aaaataatga 7501 caaaaagtaa aaataacccc ggaaggggta ataccataag ggagagtaat accatgaagg 7561 taatggaaga aataagagaa aagataagaa aggcaatcaa agaaggagtt agcctaaggg 7621 aaatagagga gataatcttg caagaggcca tgatggaaga gagggaagcc tacctagaag 7681 ttgaggacga ccacaagaac gggacctact tcagatatct gggaaccgga gacggagtat 7741 taagactcag agtaccgaga accagaaagg gtggcttcag acccaagatc cttccggaga 7801 agtacgagag gaccagccca gattacgagg acttcctcca gcagctcgtt ctatcaggca 7861 tgactccaag tcaagtcaag gccgtgttag cagccaaggg aataccgtat agtgagatcg 7921 taatgaatcg ggttgccgag agaatatcca acaaactcaa ggaatacaag agccgcgaac 7981 tacctcacga tctcctagcc ctttacatcg atgtgaagat cgtaaaggtc agaatcagcg 8041 agtcgatcat ggagagagcc atttacattg ccataggagt tgacttagaa gggaataagt 8101 tcgtcttgga ctacgaagtt agggataggg aggacttgga cggttggaag tccttcttga 8161 gcggactcgt aagcagggga gtcagcaggg ttgacgtaat cgtgagcgat gacttctctg 8221 gactcgatcg cgtcgtgtcc acgctctttc cctcctctca acaccagctc tgtataacac 8281 acatggttag gaacctcatg agggtcctcc cagacaagga ggaactaatg attagagtta 8341 gggatctaaa gtcctccagg aacgtggagg agggaaggaa ggctatattg tccctcagcc 8401 aacttgtcca acccttttct ccagcccgag ccaagaggct tcttgacgct gctgacaagt 8461 attgttcctt tctcaacttc cccagggaga ttagacacta cctctacact aataacacgt 8521 cggagagttt caactcgacc ctggctaggt tcgaggagga gctcggaggt tactttccct 8581 ctcttcgctc cttggaggtc tatctctacg tttcgatcca tgaaagtaat tcgcgttgga 8641 agttcaggcc catgtcggtg ataaggcatt actcatatca tctcaaacaa ctccacgctt 8701 caaggttcca ggtgagtctt gatgaagact tttaaccttc tgtttacata ttttctcaca 8761 caactatacc cagtagcccc ttgccctcct atggatctcc gacttagact tgtactcgcc 8821 taggaaccac cttaccacca cgtctgactc gtagtagctc cgcacgtccc tgtaggagca 8881 cgtccacaca atcataacta ttaacgctct caatatgaag aggtcagaga gacgcgacag 8941 cacttcagac gtgatcagca tgtagttcat tttcacaagt gttttatgcc ttgctgataa 9001 atgttcatag gggaccgggc cgttgtagta ttctatccaa tgcttcatgt gaatcggtac 9061 tacatcgtcc cggttccctt taagtattac gcgacttttt gcttcaagcg aaaattcaaa 9121 atttctcagt aattcacgat atcttttgaa ttattatcta taaaccttta catagattta 9181 ttcaattatt tgcacttggg acactctctc gagtggatca gagatccact cccatctgaa 9241 tagaagggga ctttcatcca taacgtctag tcccttaaag ggaagagata ctagatgctc 9301 ctcccacagt cccattaagc cctcaatcga gctggggagc ttccggtata aaaacctttc 9361 catgaaaaat cgagcatagt ccacactact tacgcaagtg atgaaacctg ctttactcac 9421 tagcatcaaa gggcttatta taatacagca cagcccaagt aataacagcc aatttccttg 9481 cacaagcagt aatcaacttc ttacccttta acctaccctt gtgctcctca taaaaacgct 9541 tgataacagg attaaccttg atggcagtca aagctgccaa gtaaaaagcc ctcctcaaaa 9601 cagcatcacc ttttttagaa ataccccttg agacaacact cttaccacta gactcaacaa 9661 caagaccaca ataagcaaca aacctcttct tatcactaaa gcgcctaaca tcaccaaccc 9721 tagccaaaat aatacaaccc aaggttttac caataccagg aatagtgaaa atcaaactat 9781 ccttggaaac aacattctca agctctttct caatctccct cttcctagtt ttaagcctct 9841 caagctcctc caaaagaaac ctaacctcag acaagacaac actatcccca cccctcaaaa 9901 cctcctccag gtttttctta gacaaactat ccctatagcc taaaagtacc aaatccctcc 9961 tcaacctatt cttaacccta gcaatactcc tagtaacaaa atcccactgg ctagtcaact 10021 ccctagcatc acttgttgta aacccactac ccatacttac aactaattcc gcaagctttt 10081 tagcatcatt cttatcactc ttcttacccc taaaatcctt gaacttcttg agaataaagg 10141 gattaatgat cctaacatca tactcattat tcaagtactt tgctaggtta acgtggtaaa 10201 ctccagtact ctcaataccc actttgcaac ccttaggcaa gatcttcctt atctcctcaa 10261 acccttgcct atcattagga aactcgtaga gtttaccttg aaaatacata attaatttat 10321 cttttgatac atctattcct gcaactgggg cctccaattg tactcaccct tatgttttat 10381 tcgggctttt tgcccaactt ccggttcgaa ttggaggcgg ccaagctccc cgtcgagctt 10441 taagcccaag gaagtcaacg gcctacaccc cagtcagatc tgtattactc agatctgact 10501 aatatgtttt atataaggag catcattaac atcactaaaa gaatttcaga aaaaaggatt 10561 atttaaatat aagaggctat ccatccccgc tggcgaggct ttccgccccc taacctccaa 10621 tttttgtaat aagattgctt cagttactag agcaatctca gcgtaaatcc cgtagtgtgc 10681 caacatgcta ttaattgtta aaggtaaacg gaatactgac aatagtatta ctaaaaactc 10741 ccgctgatgc aataatgttt agtatggagt agactaggaa atagatagct cctttcctaa 10801 cattttctaa tccaactctt tcagtatttt gctgtggcat aaataagtta atttttctat 10861 ataaaaaact tttctattat atcgtttttt aattaattgc tataataaga aattaatatc 10921 gtgaatttta tgaactcatc tattgaaatt aatatcggac tagcgtttcc ctagatgctt 10981 aaagaattaa aactagttag agaaaaaggt atttaattag ccaatttaat atttacctat 11041 gagttcgtgt gagatctttc cattaatttc aaagttaagt gccgaaggga agcgctttgc 11101 aatagtttca atttacaagg gaaataggct agagaggact ttagtatctg atggaaaagt 11161 acttcttgga agtttggata aggaagtaat tggacttgca ctggaagcat tggaaaaggg 11221 tgaggtaatt caaaaggatg tagaggatgg aaaattagtc attgaaccag tagaacctag 11281 accggctata atagtagtgg ggtctggtat tattgccaag tttatagcaa aattagcagt 11341 agatatgggc tattacgttg cagtagttgg atctggtgat gttaaggaag aggactttgt 11401 tggagtttac gccatttcaa atgatctaaa tctcttagaa caaatggtaa gtgaggattc 11461 atttgtaatt gtcgcaaatg agggaggcaa accatacgat atagatgcgt tatatatcgc 11521 aatgaaaaag aaggctaggt tcgttgggtt acttgctagc caaaagaggg cagctttaat 11581 gatttcatta ctaataaaga gaaacatccc attagaggaa attaagaaaa gattgcactc 11641 cccattaggc ttagatatcg gttcaaagac ttcagaggag atagcgttga gcatattatc 11701 tgaggtagtg ctagaactta gaggaggtac tggaaaacgc ttacaagaag ttaagaatcc 11761 ttatcttcta ttagatgacg ctttagctgg aaagattgag gataagtgta tgtttgtacc 11821 taagtcttta agtcaacaat gaatatatta acaatcaatt ccctttttaa tacatgaaag 11881 cggctattct cacacagttt aactcacctt ttgttatagg taacgctgag cctaaagggg 11941 ttggagttaa agtaaatgta gcatatgctg gaatatgcgg aagagatcta gttatatgga 12001 agggtggatt taaaaacctt aaattgcctt taatcttagg acatgaaata gtaggctact 12061 ataagggaag acctgttgcg atttatccaa atctgaattg cggaagctgt gagtactgca 12121 aaagtgggaa ggagaatctg tgcgacaatg ctagaatttt aggagaagga gagataactg 12181 gagggtatgc tgaggaggtt ataattccag aaagaaacat tataccatta ccagacgata 12241 aattagaaaa atacgccgca accatggacc ccgtagcaac tgcaattcac gcaactaagc 12301 ttgcaaattt aaatagagat agtaaagttt tagtaactgg tgcaggtgga ggagtgggta 12361 ttcatctcgt acaatatttg aaatatttgg gtatttctag tgtttatggg ctatcgtcta 12421 aaggggaaaa gctacaagaa ttgggagtaa cgcccattag tgatataaga agtgagaagt 12481 ttgatacaat atttgagctg gtaggctcta aaacaataaa cgattccttg agggcactaa 12541 agaaggaggg tactctagtt ttgataggaa atactgaagg cgagccaata acgttgttaa 12601 ggccagccat gactataatg agacaacaaa aaattatagg ttcggcatct tatactaagg 12661 cagagtacga ggaagctatt agattagtgg gagaagggaa aataaaagcg atatatgaga 12721 tttacgaact agagaggata aatgaggcgt ataggaaaat gatggagaga aaggttctag 12781 gaagagctgt attaaaggta atttaacctt ctttatacat gtagatctca taaggtgata 12841 acctaaatat tatattttta cgttggcctt tctttagttc atcatgacta acatattagt 12901 ttttgaggta agtatacgct aaattatagg ctaaaataaa acctaatgat agaaagagtt 12961 ataatcagtc tagtaggtct taagtatata tggttttacc tttcaatagt gtggaagcat 13021 tttctgtaaa cgtttctgag aaacatgaac tatttaggag agcagtaagg gaattcatgg 13081 agagagacgt tgcaccttat gttgaaaagg gtgaaaaaga aggtacagta ccaaaggagg 13141 tgctagaaaa agctaaggaa ataggtctat atggcgttgc agtaccagaa cagtacggtg 13201 gacaaggtgg agatacgcta atgactgcca tagcccaaga ggaaatatct agagtttggg 13261 cctcgttgtc tacgagaata tctgttggag gcttattcat gactccaata ttgcttttcg 13321 gtaatgaaga acagaagaaa aagtacgtta ctccagtggc tagaggagat aaagtcgcag 13381 cttttgctaa tactgaacca gccgctggat ctgacgttgc tggaatacaa acaattgcta 13441 aaaagataaa tggtaagtac gttattaatg gtagaaaaat ctttatcacc aatggtggga 13501 tagctgacta ttacgtagtt acagctagga catcaccccc agagcccaat gccagatgga 13561 aagggatatc gatgttcata gtagaaaggg aatggaaagg agttaaggta ttaaatagaa 13621 ttgagactat gggactaagg gcttcaaaca ctgcagagtt agcctttgag gatgttgaag 13681 tccccgcaga aaatctacta ggagaagagg gaaacgggtt taagtacgca atggcgactt 13741 ttgataggac aagggttggt gttgccgctc aaggagttgg tgttgcacaa gccgcgctag 13801 agagaatggt tacatattct actcagaggt ttgctttcca gagtccattg ataggatttc 13861 agatggttca agagaagata gctgaatcac taactgaagt aaatactgca agactactta 13921 cgtactgggc agctagttta tttgatcgtg gtcttgagaa tgaggctata gtagcagcat 13981 caatggcaaa attgtacgca acagatattg cagagaaggt tgcaattagg gcaataactg 14041 ttcatggtgg atatggtgta gctacttcta ctggtgtaga gagattgttg agagatgttg 14101 aggtaatgag aatatatgaa ggtgctaacg atattcaaaa actagttata ttaagggaaa 14161 ctgcgagaag actcctcgga attaagatgt aaaatttttt atagttgttt ttctaagtat 14221 tataacatga atagcgaata ttatgagtcc caattaacaa tagataagat attagattct 14281 ggttctagaa gttttccaga tagagaaata gtatacagag atattagacg atataccttt 14341 agatctttcg caaattctgt aaaaaggtta gcaaatggat taagaaagat aggagttaag 14401 aaaggggaaa agataggagt tatagattgg gatactgatg tctatatgca taattattat 14461 gcaataccaa tgttaggcgc agtgctacac acggtaaata tcagatatcc cttggagtta 14521 atagcaaaga caatattaca cgcagaggat aggtatttag tagtaagaga cgagttcatg 14581 ccacttattg aaaaagcaaa gggaataatg cctgtgggaa tgaaagtgat atcctatagt 14641 gattctaagg aaaaggtgag aagcccatta gatacaatag atttttggga attgattgag 14701 tcaaatgagc cattggaaga ggagattaat gttaatgaaa gcgatatggc aacgatcttt 14761 tacacttctg gtactactgg agaaccaaag ggcgtatggt ttaatcatag gaaaatagta 14821 ttacatgcaa tgagcgtaag cctagttggt gctagacccc cattaagctt gacctcaaac 14881 gacgtatata tgatcctagt accaatgttc cacgtgcacg cttggggata tccatatgta 14941 acactgatag caggagttaa atacgtttta cccggtaaat acgattacag ttttatacta 15001 aggttaatgg ataaggagaa cgtaacatat tcagccatgg taccaactat actgtatcta 15061 ttgctaacaa acccagatgc tcctaaatac cttcacgtat tcaaaagatg gaaagttaca 15121 ataggaggtt ccgctctacc agaaggatta gccaaaaagg cgaaagaatt aggtattact 15181 gtaataggag gatatgggtt atctgaaact tgcccagtat tgtcagtcgg ttattataac 15241 tctgcaattg aaggattgga cgacaacact aaatttatgg aacaaataac tgccggggca 15301 ccaattcctt tagttcaaat taaaattgtc gatccagcta ctggaaagga aaaggagact 15361 ggtaagatag gggaaatagt agttagagca ccgtggttaa ctcaagagta ttataaggat 15421 ccagaaaaga ctaaggcatt atggaaggga ggatggttac acaccggtga cttagcctac 15481 atggaccagt acggatatat acatatagtt gatagagaga aggacgcaat aaagagcggt 15541 ggagaattca ttccttcact actcttagag aacgccatat cattacatcc caaggtgtct 15601 caggttgcag tagttggaat taaggacgag aaatggggag aaagaccagc tgcattcata 15661 gttccgaaag agcaagtgtc agaagaggaa ataaggcaat tcctattgaa acttgcggac 15721 gagggtaaaa ttcaaaagtg gtggattcca gatagattta tattcataag ttccatgcca 15781 ctaacttcaa ccaataagat agataaaaag gtacttagag acatgacaca aactaaataa 15841 actatcaagt ggtagattaa agtatgagaa atgtagcaat tatcggaact ggacacacca 15901 aattcggggt aaggacagat gttaatttgc aagaactagc atgggaagct gttaaacaag 15961 ctcttgaaga agcaaacata gatcaaaatg aaatacaata cttcgttgtt ggtaatgtag 16021 ggaattggag ttccgaggaa ttaccagcag taatagtagg ggagtattgt aacctaacac 16081 caaaggggac tatgagagtt gaggcagcat gttccactgg aagcgcagca ataagagatg 16141 cctatctagc aattaaatct ggtgaagcag atatagcact agtcgtagga gtagaacaaa 16201 tgcatcaagc acctaatccc caagtagttg aactaattgg cagggctggg ggttatttct 16261 gggagtttga gaactttggg cttaccttcc caggatatta cgcacttcac gcctccgcat 16321 atatggctaa atatggtatg aaagaggaag acttaggaaa gatcgccatt aagaatcatt 16381 attatggggc taagaaccct tatgcacaat ttcaaaagga aataactatg gaggaatatt 16441 tgaagtccaa accagttgct tatcccctga agcttctgga ctcctctcca attactgacg 16501 gtgctgctgc aatagtctta gcatctgagg aagttgctaa aaagataact gattctccag 16561 tatggatagt atcgcaagga gttgctagtg gcactgcaaa cttgagtagg agaactgact 16621 tcacacatat agaagcagct cacattgcag cacagcaagc gtataagaga gctagaatag 16681 aattcgataa cgcatggaag aacttcgacg tagcagatgt gcatgattgt ttcacaatag 16741 cggaaataat ggcatatgaa gatttaggat tcgcaaaaag aggtgaggga tacctattgg 16801 caagagaaga acaaacatac ataggaggga aaataccagt aaacgttgat ggagggttga 16861 aagcaaaggg acacccaata ggggcaactg gggtaagcat ggcagtatca ataacaagac 16921 agttattata cagagcacat aagggaacac aagtggaagt taggaacggg atgggaataa 16981 cgcacaacgt tggaggaact ggacattacg catacgtaac aatatactca actaggaggc 17041 catctacatg agtctaaatg aaataaggga taagatgcaa aaggaaattt cccaatcact 17101 gttgatgctt gataacgcga taaagacaac taaattacca atagtgaatg aacaaaagac 17161 taataacccc ctttggattg acgtaaggga gattgaccta aggtatcaaa ttccagttaa 17221 aaggatattc aaattctttg agggattaag ggagggtaaa attctagcca cgaaatgtcc 17281 aaagtgtggc tcaatatatt ttccgcctca agatgattgt ccaaaatgca aaatatcaaa 17341 tttagaatgg attgaaatgc ctaaggaagg tgaaattgtg gcatataccg tagttaacgt 17401 caaacctccc tcattctctc actatcaaga ttatatagtg ggtatagcta ggatgagtaa 17461 tggagtaaat gttctaggct gggtaagggc taaggaagtt agagtcggga tgaaggttaa 17521 acttgaggtt attgagagga aaccagaagg atatctaact tatgaactgg ttccagtagg 17581 ttgaaatttc atgataagaa atgtattggt agttggagca gggacaatgg gccacggaat 17641 tgccgaagtt tcagccatag ctgggtataa cgtttatctg agtgatgtat ctaaagatat 17701 attgaataac gcaatacaga aggtcaagtg gagtttggag aaattgtatg aaaaaggtaa 17761 cttaaaggaa agtgttgagg acgttttggg aagaattaaa accatagaag ggttatcgaa 17821 tgagttaagg gaaattgata tatcaataga agcaatacca gagaaattgg atttaaagag 17881 acaactattt tctaagcttg aggaactatt acccaataat gcgatattgg ctactaatac 17941 tagtagctta ccaattacgg aaattgcttc tgctgtaaaa aggcaagaaa gggttatagg 18001 aactcacttc tttaatcccc cagtgttaat gcagttagtg gagataataa ggggaagtaa 18061 aacttcagac gacactgtta aacagactta tgaattcatt aaatccctta gaaagatacc 18121 aataatggtt aaaaaggacg taccgggatt tgtggttaac agaatattat tgaggattat 18181 caccacagct tgcatgcttg ttgaaaaggg gatttgtgaa tatactgcga tagacgcagt 18241 agctagatat aaattgggat ttccaatggg aatttttgaa cttgtggatt acactggtgt 18301 ggatgttaac tattacgtaa gctctgcaat gatggaaagg ggatttaagg cctatccgtg 18361 taagacacta gaggagatga caaaaaaggg agatctcggc gtaaagagcg gaaaagggtt 18421 ctatacttat ccatcaaata agtatattaa gcctaattta cctccacaac tagctgaaaa 18481 aataaatccg ttatacatta tagctcctgc gataagtgag gcaaattgga tggttaaaaa 18541 cggaattgca agcaaggaag atattgacct aggtgtcaga ttaggattaa gctttcctaa 18601 aggcattttc gattacaaaa gggagtttgg aagagagagt gtaactaaga ccttagaaga 18661 cttgagaaga atttctggta tggaagagta tttaccggaa taa //