LOCUS NC_012563:9 27560 bp DNA linear BCT 26-AUG-2011 DEFINITION Clostridium botulinum A2 str. Kyoto, complete genome. ACCESSION NC_012563 SOURCE Clostridium botulinum A2 str. Kyoto, complete genome. COMMENT locus start: 1704345; locus end: 1731904 FEATURES Location/Qualifiers source 1..27560 /organism="Clostridium botulinum A2 str. Kyoto, complete genome." gene 0..1256 /gene="" /locus_tag="" /db_xref="1704345..1705601" CDS 0..1256 /gene="" /locus_tag="" /product="phage portal protein, HK97 family" /translation="MRIINKVKKIFKNEVETIGTNPTLEELKEFFNSNIEEIANNKLT STSYYSCMQIRCNAIAKLPLKLMRETEKGSIKAKEHNLYKLLKKRPNPFTNSHDFIWA TEFNRLEYGNAFWVMDANIRGQIQALYLLDSRKVTIIVDNTGILNNKNAVYYIYEDEK QGQIIYTSDEIVHFKNFSMNGLKGTSIKKYIADTVENEQYSAKLLKDKYKNGLQDPII VQYIGDLNDAKQQKIKKKFADMGGAKNASKVVPIPTDFKVEQLETKLVNSQFFQLQGL TTRHIANAFGVKGFQLNDMEKSTYNNIEQQNKAFYSDTLQNSLTTYEQEMNYKLLTTD EQEKKGYYWQFNVDSILRSDLTSRTTSYQAGINTGYMTIAEVREKENLPYIEGTDKLI IGNGASIPLEDLGKQYRKGGENIEKD" gene 1243..2004 /gene="" /locus_tag="" /db_xref="1705588..1706349" CDS 1243..2004 /gene="" /locus_tag="" /product="serine protease" /translation="LRKINCTVFDKKSNKLKNVGFMEIKNSSNGNGELYLYGDIVSDQ WGKWSDDDTCPQDVANFLKELNSFDNLDIYINSGGGSVFAGIAIYHQLKRHNGFKTVH IDGIAASITSVISCAGDKVIIPKSAQFMIHKPTASYFWTSLNADELRKEADTLDICQD SIRNIYMENVKEDITEEEINNLINAETWFTGETVTDYFNFEVEESSEKVASTSQFYDK YKNTPNKLLKNKIIKNNEHNELKNKLQTELDLLSM" gene 2043..3218 /gene="" /locus_tag="" /db_xref="1706388..1707563" CDS 2043..3218 /gene="" /locus_tag="" /product="phage major capsid protein, HK97 family" /translation="MKKSLEMRNKLEGLKNEAQALLDENKVKDAQDKMEEIKDLKNAI GIQEALEKEEEEVLVAENNINNDPKDNNNEMPEHKAKENANCIRAMIKKVTGRSLTEA ENALLVQTPQTSAGNGEGYLLPTDVSTLIHKKIREYRSLRDAVGYMPAGALTGSFPVE DFETVSELIDFTDGTDGGDSDDIKFKNVSYALKEKAAFIKLSNTLLKMTDNALISYVV EVFAKKAVITENKIIITKLKENKKVKELKGWQDLKKSLNIDLDPAVLFGTVIVTNQTG FDYLDGEVDKQGRPILSDDIANPTQKKFKGYTVMVYSDAMLPNTGTKAPIFYGNLSEA IKFVDYNGLISFATSSEAGFMSNTTIARLIEFIDVIQVDKSDKCYIAGTIDTTVTGA" gene 3263..3520 /gene="" /locus_tag="" /db_xref="1707608..1707865" CDS 3263..3520 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MDLEQVKKFLRVDFSEDDTYITLLIDVAKEYIVDAVGKYDETSA RYKLLLFNIVSTLYENRQYTIDRSNEKVAYTLKSIILQLQL" gene 3539..3874 /gene="" /locus_tag="" /db_xref="1707884..1708219" CDS 3539..3874 /gene="" /locus_tag="" /product="hypothetical protein" /translation="VEGLKLNTLLELWGMVPFKNELGENDTREGKIKDIWCEVISIGG SVSTISNTEIEYSSVTHKIRCRKLSIKEPSKDMSFKDKEGNKYEVQYFQRDFKKNKFI EFMTKILYE" gene 3884..4093 /gene="" /locus_tag="" /db_xref="1708229..1708438" CDS 3884..4093 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MGEFELREWEKEQLVQKYNELKEEHEGIKRQLDEAGVLIDQLHK IKAECFEKMQGIRKVLLEKYNYPVV" gene 4096..4509 /gene="" /locus_tag="" /db_xref="1708441..1708854" CDS 4096..4509 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MANGFNTTQLDKFSKGLLNTAKNEYPKKSKSFLRKEARKLNKKN KATFASKGIGEETGNLKKGFKAGKLYKYKGKELAIRAYNSSPHAHLLNNGWMHKAKNG DEKFIPGFHFIEESAQSFNSEYYTDIDEFLDELFD" gene 4570..4995 /gene="" /locus_tag="" /db_xref="1708915..1709340" CDS 4570..4995 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MQMFEVRKDINQISGNYAGDYPNIAMSGMLKLKIDKDKLIFKQL WKTYHKLDLKNITDVQLKTEEEISKDVTLTRLLVFGIFALGLKKKRTQERYFIIISTE EEGFKNDFVMEIDSAKGFGLPMAQGFVKTLRKEVIKYRD" gene 5198..5488 /gene="" /locus_tag="" /db_xref="1709543..1709833" CDS 5198..5488 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MLNGEASQRNFDIGLFYFSQNRETNKIELLEMQDLLSLIFQNGI KVYDDYYIAVNECEFDSRGEEGLLITTLSDLYSLSEIEQTGEPLEELEMERW" gene 5493..6578 /gene="" /locus_tag="" /db_xref="1709838..1710923" CDS 5493..6578 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MANTLPNINILFKQRAATFTQRGGVAILLLKDDTDKNFNTAEYK TLTDLELDEAKYTPTNLQYIKDTLLGKTSKVAVVRVDVEKEFTDALNIVKNLYSTGWI SLVSETKTDYDTLVSWIKTRRDTDKKTFKAIVFNPTTPPDYEGVVVLGNEKVIFKDNT RGEKAGYEFLPTLLGYIASAGVDTGTTYMAMENLKTVSEPASTNQEIQAGKLILINDE NIVKIGLGVNSLTTFTQDKEDFSLIEVIETMDLIKDDIRKTFKNNYIGKFKNKLDNQM LFISAVNTYFSNLAARDVLDSSYNNESFIDVEAQRKAWVDSGKPEAKEWDDTTVKNTT FKRKLFLGANIKILTSMTDLTLVITME" gene 6589..7017 /gene="" /locus_tag="" /db_xref="1710934..1711362" CDS 6589..7017 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MATNKGNEVISGNEGRVWINTELWSNLSSIEAKCSLETEDIRFV GDPNKYTKITGNNIEGTVTIKKTDSRAQRLLAEGFRTLNMPDISIVIATAKVNNSKVE RLKLEDVTFTELQLAKLEAGAMVEEELPFTASSFEYLELI" gene 7033..7452 /gene="" /locus_tag="" /db_xref="1711378..1711797" CDS 7033..7452 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MSKAKKIALEDFIKKATDKYNKRKRVVDIEVEGFGILTFTRPSD SDLLEFKNTLANSIKMSKDESIDKLDYRQMLNASKELIYNSCEFLHSNELMQDLECGE PFDIPIKVFGIDGTIQLAQKINEAFEDSNVETVIKNS" gene 7521..7652 /gene="" /locus_tag="" /db_xref="1711866..1711997" CDS 7521..7652 /gene="" /locus_tag="" /product="hypothetical protein" /translation="LDYYLNLDALQKQFYIESMQYNIKLKVKYDKSKLDYIFGEGKK" gene 7688..10318 /gene="" /locus_tag="" /db_xref="1712033..1714663" CDS 7688..10318 /gene="" /locus_tag="" /product="phage tail tape measure protein, TP901 family, core region" /translation="MASKTIGVVLSLRDQMSNPLLKINKNVQGVSKEAKRASQQVANF ATKAQKGFEKAGDKVLKFGLGLATLAGGLIVKTGVQGLGELDEGARKVKSIAQDSLQL DNIQKGLLKTSNDTGIAVKELSDTQYDAISSGVKANESIQAAVTSAKLAKAGFSDSNS SLKILTSTMNVYGLTGQKAMQSISDKLLVTQNLGVTTVGELANSMGSLTPIAKSAGSS IDEMLAGMASLTKNGLKTEEAVTSLKSVFSSVIKPTEEASKTAQQLGIDFSASALKSK GFAKFLEEIKVKTGGNTETMGKLFGNVNALSGALVLTGKGFGDFNTSLDAMKNSVGLT DQAFETMNNSLISKFGKMKNRLTNMATEMMQGTGGQLGVLIDDITGKLKQWQEDGTIE QVANKVATGFMKMYDIISKVISFLVEHKDAIANVAIVFASFYIAIKIFKVLKGVIFGV QIAIGLLNGTLMLTPLGWVMVAITAVIAIGLLLWKNWDKIKQVAQTLWTAIKTVFTNI WTTITTVFTNIWTTITTVASNIWTSITTVFTNIWTTITTIFTAIWTTITTIATNIWSS IVSIFTTIWNVIVTIFTPIKLFIEAVWKGILAVIIIVGAFIWNAIVTMWTNVWNVIQP ILTAIWNVITTVWTAIWTTITTIAMAIWNTIVNAWNTIAGVVSAVMSAIWGVISSIWS SIYGTVSGIMSSIWSTITEIWNNIVSTVSDIVGNIASTISDGFNSLIGTCSDIFNNIK NTVMDIFQGIWQGIKDIINGGIGMLNNFIGGVNKVISKANKVPGVNIGAVSEIPKFAK GTQYSPAGMALINEEGGELRKLSSGETIIPADKSRQLMSGNSSPEINIYITGNVGTEE FFNQAGEHITNQIKLALQNM" gene 10365..10796 /gene="" /locus_tag="" /db_xref="1714710..1715141" CDS 10365..10796 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MANIYFSTLDRKQLYELPILPEEMPELSKSSKNEIFETFNNGEY NFLGEVSLISFSLESWLPAYPNKYRWAKSQINPYLLINMWNTAQNTKKPLRIVINRNK NTFLPQELLNWMVSIENISWHELTNGDVAYKLDLKQYREIK" gene 10796..11728 /gene="" /locus_tag="" /db_xref="1715141..1716073" CDS 10796..11728 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MWYLYTSYIVGKGYTTKEIIGQCNNLSWSNDVDTLATSLSFDSI LDLAEGRSKIILRQDKITVFEGVVVNKNNKENVHSYTAMDYAWYLNKNKYVMQFRNIN AKSALQQICAKVGIKVNIRTRLTTRINKLYFQESLSDIIKDILEQCKREIGEHYIMEM QGKTLYINRVIDLKINSTVLIEKDYSISRSIEDMQNNIIAVNNDGRVLASVKDNKNIK IFGELTDIISVEDENTSRANNIARNELKEKNKIKKELSFNTIDTGKGIYINCNRLIRV NLGKYGVNGWYRIKSTQHTLNNNIHKIGITIDFS" gene 11739..12056 /gene="" /locus_tag="" /db_xref="1716084..1716401" CDS 11739..12056 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MDYGIEFAQWLKKRNNKDRIGTTIGEVVRGGLDYRISIMDNKLY LDPSNSTLCNSLKDRVEERTIELNNTSYNAKITYSNILKKYDKVLVIENESGQHFFIV DKI" gene 12068..12505 /gene="" /locus_tag="" /db_xref="1716413..1716850" CDS 12068..12505 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MALLPEEDIIIEEVEQIEEEQTLSKLGKVFLFDFKKNKYVIKDG KLVECTERQALEQWIHWILLTYKDKYNVYKGTDFYCNIEDLAGKKRNAFILSELQREV EEAVIKHRYVDHIENFVTTQEKSILNVSFDVVTKDNEVINISA" gene 12517..13626 /gene="" /locus_tag="" /db_xref="1716862..1717971" CDS 12517..13626 /gene="" /locus_tag="" /product="hypothetical protein" /translation="LSVNVKTQEKLIKDMLNNISNTYEKSEGHLTYDITKTNAIELAL LYQYALSIANLRLVKDLRGDDLTARVYDNKGIVRKVATRAKVILTLTGTGTIDKEDLF GTPNKIEFASLEKKQIEGTGTILAECTQVGNIGMVGANSIAEFPITIAGFTEVNNSNP SYDGFEEESDESLRQRYYESLKNPITSNNQAHFIYWAKSATGVGNAKVIPLWDGDLTV KVIIINSDMQPASVDLVNTVQEYIDPKGILDTNTNTWSLWGTGAGASAIGNYCTVVSA TAKNIDLECSITKANGYSDEEIKQNISSKIAEYLKEIAFSATINYVSHAKIISLILSA DGVLDATNVKVNGSLSENVIIGEEEVATMGAVTLI" gene 13638..14168 /gene="" /locus_tag="" /db_xref="1717983..1718513" CDS 13638..14168 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MNIEQQLIANLHKRVRQDSYVKNLCNASGIEMDTIEDVLEDIKK QFKFETMTWSADLLASEMGIKLDPSLKQDEKNSIIAARWKSEGKADLNLLQAICNSWK NGNVKVSFIDGKIVFKFVGEYGIPADLDSLKKQIDLSKPSHLAIDYLFAYLLLKDVEE ITLTKLENTTLNKFAF" gene 14179..14985 /gene="" /locus_tag="" /db_xref="1718524..1719330" CDS 14179..14985 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MSKETENLKLFKYDPETDDFNTTTFNVTQALNNNWDKIDAHLED ASSQLADITTLTGNKDNLKTTNKTNLVSAINEVFTSGNNVKINTVDALLQLDKSLQIT KESKWEDIIKNISKISTGKKWAQGTANVNYYGPEVGIFMESNYPLSSASVNTNCGFKP SIVILTTIGITPRTNPDDYFRSDDRYSEPRIELYIYNELLQVKITFKTKSGYSSDIAY DREYSIEKINSIGNTIYTSLHIMRYSVRVEKGTSTAERYMFDKVNWYAYE" gene 15001..15306 /gene="" /locus_tag="" /db_xref="1719346..1719651" CDS 15001..15306 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKRGSLIIYDNSGKVWVNTGDAEGCIPPHTPPDGLPYIITEFGE FNDKIIKGIDVTVTPHKLITEDIPHIETEEEKLKKELLKAQSEVVNLKYKEVLNNIK" gene 15322..15507 /gene="" /locus_tag="" /db_xref="1719667..1719852" CDS 15322..15507 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MILYDLLKNLIDNNYYEKEDMNNKLNVFYTFNQIDIEQYSELMA KVNPAAKENTIEKVVTQ" gene 15595..15798 /gene="" /locus_tag="" /db_xref="1719940..1720143" CDS 15595..15798 /gene="" /locus_tag="" /product="bacteriocin UviB" /translation="MENEIIKLVATQGAFAVFFAYLLFYVLRENSRREGKYQDIIKEL AEKLNVIEDVKKTVDKIEGKLEG" gene 15800..15973 /gene="" /locus_tag="" /db_xref="1720145..1720318" CDS 15800..15973 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MDRVLRKITSARWLIAVIMTIVFAILAIKNTLNTEFITIYTMVV AFYFSKDRKEQDK" gene 16016..16774 /gene="" /locus_tag="" /db_xref="1720361..1721119" CDS 16016..16774 /gene="" /locus_tag="" /product="bacteriophage endolysin" /translation="MKIGIDCGHTLSGADYGAVGIKAESNLTREVGTKVIAKLKALGH TVINCYKDSCSSLNDSLSYRTNTANNNNVDLYVSIHFNCYNGSAYGTEVFTYGGKSFT EASRVLNNICALGYTNRGLKDGSGLYVLKHTKAKAMLIECCFCDNAGDMNRYNAENMA NAIVKGLVGTTVATPNKPKEVVKVQKPKYDETIPTGESIFKIPGTTGYIEQATDGRLI IHKDRGNYIAIGKGFIDCYWNDNKGNGCNKRLSN" gene 17098..17250 /gene="" /locus_tag="" /db_xref="1721443..1721595" CDS 17098..17250 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MKILNYLLIISITIILLLLIKLTYNKRKKAKLEIEKHEIENKKG EDNGKE" gene 17237..17419 /gene="" /locus_tag="" /db_xref="1721582..1721764" CDS 17237..17419 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MAKSKQTEANKKWYDKNKEHAKYLNKRSHTRSFIKNFAKLEDLE ELQKLIEERKELLRQE" gene 17430..17675 /gene="" /locus_tag="" /db_xref="1721775..1722020" CDS 17430..17675 /gene="" /locus_tag="" /product="putative lipoprotein" /translation="MKKEIRFLIIGLLLGACTRFIGIATAIEQAEDNCPSNGEYMYCT DQGKPLWISIYDVHQEEKFIYLRQPNSNKIIKLTQLK" gene 17820..18326 /gene="" /locus_tag="" /db_xref="1722165..1722671" CDS 17820..18326 /gene="" /locus_tag="" /product="hypothetical protein" /translation="MENKKNKKPFYKKWWVWILAIIILAGLGQGTGDKKKAQKTATQQ EQKKEDAKRDAEKKAKKEKEKKAKEEAEKKPKKEDNEATLITTAQGVVKKNLKAPSTA KFPWSFKEYNIQESKSENKDMIIYTVTGYVDAENSFSAKIRNNFIVKMECTKDLSKYR VLDVNITE" gene 18483..18971 /gene="" /locus_tag="" /db_xref="1722828..1723316" CDS 18483..18971 /gene="" /locus_tag="" /product="hypothetical protein" /translation="VITLLNIAYELKNNESLKGKADKIKIVFLDNEESGLLGSNLLSK YWQEKDEYFKEKKIINFDCVGIGDIPIVYYSKELDYELADFLRNILGYYEKNSKKFMC KYYPLSDDYSFKKNPAISIIFSNNSIIPGGYYIPNVHCSKDNVLKLENIQWLTREILK KI" gene complement(19068..19706) /gene="hlyIII" /locus_tag="hlyIII" /db_xref="1723413..1724051" CDS complement(19068..19706) /gene="hlyIII" /locus_tag="hlyIII" /product="hemolysin III" /translation="MLNEFYTKGEEIANAITHGIGALLSIAALVILIVFSAKYGDAWY VSSYSIFGSCLFILYLESTLYHSLQGSKVKKIFRIFDHSSIFLLIAGTYTPFILTSLR DPLGWTIFGIEWGLTLIGIILKVFTTGKYEKLSTAIYIFMGWLIMLHAKKLVLVIPRI SLIYLIVGGVIYTVGAFLFMLDDIPYNHPIWHLFVIGGSVFHFFSLFYMIPR" gene complement(19827..20924) /gene="ychF" /locus_tag="ychF" /db_xref="1724172..1725269" CDS complement(19827..20924) /gene="ychF" /locus_tag="ychF" /product="GTP-binding protein YchF" /translation="MKLGIVGLPNVGKSTLFNAITKAGAESANYPFCTIEPNVGVVSV PDKRLDVLEKMYNSKKKVPTAIEFYDIAGLVKGASKGEGLGNKFLSHIREVEAIVHVV RCFEDSNIVHVDGSVDPIRDIETISLELIFSDIELMQRRIEKNSKLAKSGNKEAKTEE ALMKRIVAHLEKGKPVRTLELEEDEEKLVKSYFLLTSKPVLYAANVSEDDLMSGNPEN EFVKKVKEFAKAENSEVITLCARLEEELSTLEDDEKAEMLSEYGLKESGLDKLVQSSY KLLGLISFLTAGQVEVRAWTIVKGTKAPKAAGKIHTDIEKGFIRAEVISYDKLIECGS EAHAKEKGFFRLEGKEYVMQDGDIVNFRFNV" gene 21618..22088 /gene="mraZ" /locus_tag="mraZ" /db_xref="1725963..1726433" CDS 21618..22088 /gene="mraZ" /locus_tag="mraZ" /product="mraZ protein" /translation="VVQSGAKITNWGGDMFIGEYNHGLDTKNRIIIPAKFREELGKNF VLTKGLDGCLYVYPKSQWEVLQKKLETLPLTNKNARAFVRFFFSGAHELELDKQGRTL IPQNLLEYGQIQKEIVSIGVSNRIEIWSKEKWEEYNNSNIDYDSIAEQMSELGI" gene 22168..23097 /gene="mraW" /locus_tag="mraW" /db_xref="1726513..1727442" CDS 22168..23097 /gene="mraW" /locus_tag="mraW" /product="S-adenosyl-methyltransferase MraW" /translation="MEFKHISVLLEETIDSLNIKEDGVYVDCTLGGGGHSKEILKKLS HKGKLIGIDQDTSAIKAAKERLKDYENVIYVHNNFYNIDSILEELDIDKVDGIIMDLG VSSYQLDEASRGFSYMKDAPLDMRMNREENLSAYNVVNSYEEEELFKILKNYGEEKFS RKIARFIVEKRTENPIETTGELVEIIRKAIPAKFQREGHPAKRTFQAIRIEVNKELQI LNKAIEDSVNRLNKDGRLSIITFHSLEDRIVKVKFKELEKPCTCPPSFPICVCGKEPQ IKIITKKPIEPSKEEKEINSRSRSAKLRVCRKI" gene 23179..23682 /gene="" /locus_tag="" /db_xref="1727524..1728027" CDS 23179..23682 /gene="" /locus_tag="" /product="putative cell division protein FtsL" /translation="LVMLEAKNRFNGNTVLKPQYEPQIEKDKVKEKKEQYKRNKKIQQ KLLKKKFKTLRNIIIAFIIGVTLVARYGILYSMQKDLSNINSHISEVEKENENLKVEL VHYNNLSNIEKVAGQNLKMVPPDKDSAIYTDLSYNNFKTENSKNHIGEKHNAFLEFFS NLKKVLF" gene 23698..25878 /gene="" /locus_tag="" /db_xref="1728043..1730223" CDS 23698..25878 /gene="" /locus_tag="" /product="stage V sporulation protein D" /translation="LSNSKYRDKVIIRKRMMFIFALLILAFIGLVIKMGTIMIGQSPE LKKKAVDQWTSEVKIDAKRGRILDRNGNELAVSANVYRVDLDMNTLRSTMEEKKLSKN DVASKLSKALDMEQKEVEKVLNKKLPSGLPLASATLKRRIEKDKADKVRELDLRGILV SADTKRYYPNNNFLSHVLGHTNSDGKGLTGVELYYNNILSGKPGVRIAETDNKSKELP YTISEYTKPEDGKDLVLTIDEMIQHFSEKTAEQALKDNKAKAVSVVVMDPRTGEVLAM ANKPDYNPNDPWQEGKSYEELQQNWRNRSVNDTFEPGSVFKVFTAATALEENLITSED KFTCGGSITIGKRTIRCWKSGGHGTQNFIEILKNSCNVGFAQLGHKIGKEKLNSYIQK FGFGKKTGIDLPGEAPGITKKTENISDIDLATISFGQANTLSIVQYLQAFNAVANGGN LIKPHVMKEVGHFDEEKNKEIIEKKNTIESKQILNSQKMATLRSYLEKVVSEGGGKKA YIAGYHIGGKTGTAQKAGKGGYMPGKYVASFAGMAPADNPRITVFVSIDEPDPSNYYA GQIAAPAAQGLFKDIFNYLALKSDAQGEDIAKSLLKDITIPEVRGKSKEEAQKILKDL KLDCEIQSEGEYIVDMNPKPGYTVKEGSKIVLYTGNSQNYNKVVVVPNVKGYTVEQAM SVLNSIGLRGDIQGDGIISHQSIEANKEVKKGTMVNLKAEPIGD" gene 26108..27559 /gene="murE" /locus_tag="murE" /db_xref="1730453..1731904" CDS 26108..27559 /gene="murE" /locus_tag="murE" /product="UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase" /translation="MNLNLILKSLEYSFIKENKKEIEKIEYDSRKVKEGDLFVCIEGY ATDGHKYAKKAYDNGAKVIVCEKDLEDLSYYKDCTIIKVSDSRKALAIMSSNYYGNPS KHIKIIGITGTNGKTTSTFMMKAILEKAGYKVGLLGTIANYIGNKKIESHRTTPESLE LQKLFKDMVDEKVDYCVMEVSSHSLYLDRVYGVEFKEAIFTNLTQDHLDFHKTFENYF NSKLILFKNAQNSVINIDDSYGEKVLKKALGNKITYGVEKNCDLKAENLHMHSRGVEF DTIFKNEKETIALNIPGKYNIYNALGSIGACLLEGIPLKTIKEALEDMPSVPGRCEIV TKNYNLGYDVIVDYAHTPDGLENILNTAREFTKGRLISVYGCGGDRDRTKRPIMGKVG SNLSDIAIITSDNPRTEDPKLIIKDVLEGIERDNYIVVEGRRDAIRKAMEIAKENDVI VVAGKGHEDYQILKDKTIHFDEREVIEELIKEI" ORIGIN 1 atgagaataa taaataaagt taaaaaaata tttaaaaatg aagttgagac aataggtact 61 aatcctactt tagaggaact aaaggagttt tttaacagca atattgaaga gattgcaaat 121 aataaactta caagtacaag ttattattca tgtatgcaaa taagatgcaa tgctatagct 181 aaattaccat tgaaacttat gcgagaaact gaaaaaggat caataaaagc aaaagaacat 241 aatttatata aacttttaaa gaaaaggcct aatcctttta ctaattcaca tgatttcatt 301 tgggctacag aatttaatag actagaatat ggcaatgctt tttgggttat ggatgcgaat 361 attcgaggtc aaatacaagc tttatattta ttagatagta gaaaagtaac tattatagtt 421 gataatactg gaattttgaa taataaaaat gcagtttatt atatttatga agatgaaaaa 481 caaggtcaaa ttatttatac aagtgatgaa atagtacact ttaagaattt tagtatgaat 541 ggattaaaag gtactagcat taagaaatat atagctgata cagtagaaaa tgaacaatat 601 tcagctaaat tattaaaaga taaatataaa aatggacttc aggatcctat tatcgttcaa 661 tatataggtg atttgaatga tgctaaacaa caaaaaataa agaaaaagtt tgctgatatg 721 ggtggtgcta aaaatgctag taaggttgta ccaatcccaa cagatttcaa agtagaacaa 781 ttagaaacta aacttgtaaa cagtcaattt tttcaattac aaggtcttac tacaagacat 841 attgctaatg cttttggtgt aaaaggcttt caacttaatg atatggaaaa aagtacttat 901 aacaatatcg aacaacaaaa taaagctttt tatagtgata ccttacaaaa ttctttaact 961 acttatgaac aagaaatgaa ttataaacta ctaactacag atgaacaaga gaaaaaagga 1021 tactactggc aattcaatgt tgatagtatt ttaagaagcg atttaacaag tagaacaact 1081 tcatatcaag ctggaattaa tacaggatat atgacaatag cagaagttag agaaaaagag 1141 aatttacctt acattgaagg cactgataaa ttaataatag ggaatggtgc aagcatacca 1201 ttagaagatt taggaaagca gtatagaaaa gggggtgaga atattgagaa agattaattg 1261 tactgttttt gataaaaaat ctaataaatt aaaaaatgtt ggatttatgg aaataaaaaa 1321 tagtagtaat ggaaatggag agctatattt atatggagat atagtaagtg atcaatgggg 1381 aaagtggtca gatgatgata cttgcccaca agatgtagct aattttttaa aagaattaaa 1441 ttcttttgat aatttagata tttatattaa tagtggtggt gggtctgtat ttgctggaat 1501 tgctatctat catcaattaa aaagacataa tggctttaaa actgttcata ttgatggaat 1561 agcagctagt attactagtg taatttcatg tgctggtgat aaagttatta tacctaaaag 1621 cgcacagttt atgattcata agccaacagc tagttacttt tggacttcac ttaatgctga 1681 tgaattaaga aaagaagctg ataccttaga catatgtcaa gattcaatta gaaatattta 1741 tatggagaat gtaaaagaag atattacaga agaagaaata aataatttaa ttaatgctga 1801 aacatggttt actggtgaaa cagtaacaga ttatttcaat tttgaagttg aagaaagttc 1861 agaaaaggta gctagtacaa gtcaatttta tgataaatat aagaatactc ctaataaatt 1921 attaaaaaat aaaataataa aaaataatga acataatgaa ttaaaaaata aactacaaac 1981 tgagctagat ttacttagta tgtagttttt tttatgtaaa aaattaaaaa ggaagtgtat 2041 taaatgaaaa aatctttaga aatgagaaat aaattagaag gtttaaaaaa tgaagcgcaa 2101 gctttattag atgaaaataa agttaaagat gcacaagata aaatggaaga aattaaagac 2161 ttaaaaaatg ctattggcat tcaagaagct ttagagaaag aagaagaaga agtacttgta 2221 gctgaaaata atattaacaa tgatccaaaa gataataata atgaaatgcc agaacataaa 2281 gctaaagaaa atgctaattg cataagggcc atgataaaaa aagttactgg aagaagtcta 2341 acagaagctg aaaatgcttt attagttcaa actccacaga ctagcgcagg aaatggggaa 2401 ggctatctac taccaacaga tgtttcaact ttaattcaca aaaagataag agaatataga 2461 agtttaaggg atgcagtagg atatatgcct gctggtgcat taacaggatc attcccggta 2521 gaagattttg aaacagtatc agaacttatt gattttacag atggtacaga cggaggcgat 2581 agtgatgata ttaaatttaa aaatgtatct tatgctttaa aggaaaaggc agcattcatt 2641 aagctatcta atactttatt aaaaatgaca gataatgctt taatatctta tgtagttgaa 2701 gtttttgcta aaaaagcagt tataacagaa aacaagataa ttattactaa attaaaagag 2761 aataaaaaag taaaagaatt aaaaggttgg caagacttaa agaaatcctt aaatatagat 2821 ttagatccag cagttttatt tggtactgta attgtgacta atcaaactgg atttgattat 2881 ttagatggag aagtagataa acaaggtagg ccaattttat ctgatgatat tgctaatcca 2941 acacaaaaga aattcaaagg atatacagtt atggtttatt ctgatgcgat gttgccaaac 3001 acaggaacta aagcaccaat tttctatggt aatttatcag aagctattaa atttgttgat 3061 tataatggat taattagctt tgctacttca agtgaagctg gatttatgag taatactact 3121 attgcaagac ttatagaatt tattgatgta attcaagtgg ataaatccga taagtgctat 3181 atagccggta ctattgatac tactgtaact ggtgcttaac taagagtttt tacactcctt 3241 taaaatttaa ggagggataa tatatggatt tagagcaagt aaaaaagttc ttaagagttg 3301 attttagtga agatgatact tatataacgc tactaattga tgttgctaaa gagtatatag 3361 tagatgcagt tggtaagtat gatgaaacaa gtgctagata taagctgttg ttatttaata 3421 tcgtttctac tttatatgaa aatagacaat atacaataga taggagtaat gaaaaagttg 3481 cttatacatt aaaaagtatt atattgcaat tacaattgta atatatagga gttgataatg 3541 tggaaggttt aaaattaaat accctgcttg aattgtgggg tatggtacct tttaaaaatg 3601 aattaggtga aaatgataca agagaaggga aaataaaaga tatatggtgt gaagttattt 3661 cgataggtgg aagtgttagc actatatcca atacagaaat agagtattcc agtgtaaccc 3721 ataaaataag atgtagaaag ttaagcataa aagaaccaag caaagatatg tcttttaaag 3781 ataaagaagg aaataagtac gaggtacagt attttcaaag agattttaag aaaaataaat 3841 ttatagagtt tatgacaaaa atattatatg aatagaggtg ctaaatgggt gaatttgaat 3901 taagagaatg ggagaaagaa caattagtac aaaaatataa tgagttgaaa gaagaacatg 3961 agggtataaa aaggcaacta gatgaagcag gggtattaat agaccaactt cataaaataa 4021 aagctgaatg ttttgaaaaa atgcaaggta taagaaaggt actcttagaa aagtataatt 4081 atccggtggt gtaattatgg ctaatggatt taatactaca caattagata agtttagcaa 4141 agggctacta aatacagcta aaaatgagta tcctaaaaaa tcaaaatctt tcttaagaaa 4201 agaagccaga aaattaaata aaaaaaataa agctactttt gcctctaagg gtataggaga 4261 agaaacaggt aatttaaaaa aaggctttaa agctggtaaa ttatataagt ataaaggtaa 4321 agaactagct ataagagctt ataacagttc cccacacgca catctactta ataatgggtg 4381 gatgcataaa gctaaaaatg gggacgaaaa attcattcca ggattccatt ttatagagga 4441 atctgcacaa tcatttaata gtgaatatta cacagatata gacgagtttt tagatgaatt 4501 atttgattaa ttaagaaaat attccttaaa aatataaaat atgttattct atatttgggg 4561 ggtgcataca atgcaaatgt tcgaagtaag aaaagatata aaccaaataa gtggcaatta 4621 tgcaggcgac tatccaaata ttgcaatgag cggtatgctg aagctaaaaa tagataagga 4681 taaattaata tttaagcaac tatggaaaac atatcataaa ttagatttaa aaaatatcac 4741 agatgtacag ctaaagacag aagaagaaat aagcaaagat gtaacattaa caagactttt 4801 agtttttggg atatttgcct taggattaaa gaaaaaaaga acccaagaaa gatattttat 4861 tataatatct acagaggaag aaggatttaa aaacgacttt gtaatggaaa tagatagcgc 4921 taaaggcttt ggtttaccta tggcgcaagg attcgtaaaa accctaagaa aagaagtaat 4981 aaaatataga gattaagaat atgcaatgca tattcttttt ttatttggag ggattataga 5041 ttgtaacatt aaaagaaata aataaggcta tagtacagca ggttaaagaa ggtttaaagg 5101 atacagatta taaagatatt caattttcat ctacagatat aagagaaaag atcacaagac 5161 cttcttttta tgtagatttt cttgaaaata aaacaagtat gttaaatgga gaagcaagtc 5221 aaagaaattt tgatattggg cttttttatt tttcccaaaa tcgagaaacc aataagattg 5281 aactattaga aatgcaagat ttgttaagtc ttatattcca aaatggaatt aaagtttatg 5341 acgactatta catagctgta aatgagtgtg aatttgattc tagaggagaa gaaggtttgt 5401 taataacaac attaagtgac ttatatagtc taagtgaaat agaacagacc ggagaacctt 5461 tagaggaatt agaaatggaa aggtggtaaa tatatggcta atacattacc aaatataaat 5521 attttattta aacagcgcgc ggcaactttt acccaaaggg gaggagttgc tattctgctt 5581 ttaaaggacg atacagataa aaattttaat acagcagagt acaaaacact aacagatttg 5641 gaactagacg aagctaagta tacaccaacc aacttacagt acataaagga tactttatta 5701 gggaaaacaa gcaaggttgc agttgtaagg gtagatgtag aaaaagaatt tacagatgcc 5761 ttgaatatag ttaaaaatct atattcaacc ggatggataa gtctagtgtc agaaactaaa 5821 accgattatg atactttagt ttcttggata aagactagaa gggatacaga taaaaagact 5881 tttaaagcca tagtttttaa tcctacaaca ccaccagatt acgagggagt tgtagtacta 5941 ggaaatgaaa aagtaatttt taaggacaac actagagggg aaaaagcagg gtatgagttt 6001 ctacccactc tattaggata catagcatct gccggggtag atactggaac gacttatatg 6061 gctatggaga atttaaaaac tgtttcagaa cctgcaagta ctaatcaaga aattcaagct 6121 ggaaagctga ttttgataaa tgatgagaac atagtaaaaa ttggattagg agttaattct 6181 ctaactacat ttacccaaga taaagaagat ttttctttaa ttgaagtcat agaaacaatg 6241 gatttgatta aagacgatat aaggaaaact tttaaaaata attatatagg taaatttaaa 6301 aacaaactgg ataatcaaat gttatttata agtgccgtta atacttattt tagtaatcta 6361 gccgcgagag atgtactaga cagttcctat aataatgaaa gcttcataga tgtagaagcg 6421 caaagaaaag cttgggtgga tagtggaaag ccagaagcta aagaatggga cgatacaaca 6481 gttaaaaata ccactttcaa aagaaaatta ttcttaggtg caaatataaa gatattaact 6541 agtatgacgg atttaacact agttatcaca atggaatagg aggggtttta tggctactaa 6601 taaaggaaat gaagttatat ctggaaatga aggacgtgtt tggattaata cagaactatg 6661 gagcaattta tcttccatag aagctaaatg cagtttggaa accgaagaca taagattcgt 6721 aggggatcca aacaaatata caaaaataac tggaaacaat atagagggca ctgtaacaat 6781 taaaaagaca gattctaggg cgcaaagatt gctagcggaa gggtttagga ctttgaatat 6841 gccagacata agcatagtta ttgcaactgc aaaggtaaat aatagtaagg tagaaagatt 6901 aaaattagaa gatgttacat ttacagaact tcagcttgcc aagctagagg ctggcgcaat 6961 ggtagaggaa gaactaccgt tcacagcaag ttcattcgaa tatttagaat tgatttaagg 7021 gggataaata agtatgagta aagctaaaaa aatagcgtta gaggatttta taaaaaaagc 7081 aactgacaag tacaataaaa gaaaaagagt tgtagatata gaagtggaag gtttcgggat 7141 actgacattt acaagacctt ctgactctga tttattagag tttaaaaata cattagctaa 7201 tagtataaaa atgtctaaag atgaaagcat tgataaatta gactatagac aaatgttaaa 7261 tgcatctaaa gaacttatat acaatagttg tgagttttta catagtaacg aacttatgca 7321 agatttggag tgtggagaac cttttgacat tcctattaag gtattcggta tagatggaac 7381 tatacaacta gcacaaaaaa taaatgaagc ttttgaggat agtaatgtag aaacagtaat 7441 aaaaaactca taagaggtaa taatgacgag ggcggggaac taagttggat aagctactac 7501 ttagatagaa gttcccaacc tttggattat tacctcaatc tagacgcgtt acaaaaacaa 7561 ttttatatag agagtatgca atataacatt aaacttaaag ttaaatatga taaatcaaaa 7621 ttagattata tatttgggga aggtaaaaaa taaccttcct ttttattttg taagaaagga 7681 ggttatatat ggcttcaaaa accataggtg ttgtcctttc tctacgcgac caaatgagta 7741 acccactact gaaaataaac aaaaatgtac aaggggtttc taaagaagca aagagagctt 7801 cacaacaagt tgcgaatttt gctaccaaag cacaaaaagg ttttgaaaaa gcaggagaca 7861 aagttttaaa atttggttta ggattggcaa ctctcgcagg agggttgata gtaaaaacag 7921 gtgtgcaagg attgggcgaa ttagacgaag gtgctagaaa agttaaatca atagcacaag 7981 atagcttgca attagataac attcaaaaag gcctgcttaa aacgtcaaat gatacaggaa 8041 ttgccgtaaa agaattatct gatacgcagt atgatgctat atcatctggt gtgaaagcaa 8101 atgaaagtat acaagcagcg gttacatcag ctaaactggc taaagctgga ttttcagatt 8161 ctaatagctc tcttaaaata ctaacttcta ctatgaatgt ctacgggtta acaggtcaaa 8221 aagcaatgca aagcatatcg gataaactgt tagttactca aaatctaggt gtgacaaccg 8281 ttggggaatt ggcgaattcg atgggatcat taacacctat tgctaaatct gctggttctt 8341 ctatagatga aatgttagca ggaatggcaa gcttaacaaa gaatggattg aaaacagagg 8401 aagcggtaac atctttaaaa tctgtgtttt caagtgtaat taaaccaacc gaagaagctt 8461 ctaaaaccgc tcagcaatta ggaatagact tttcagcgtc tgcgttaaaa agtaaaggat 8521 ttgccaaatt tctagaggaa ataaaggtta aaactggtgg gaatactgaa actatgggta 8581 agttgttcgg aaacgttaac gcactatctg gtgctttggt acttacagga aaggggttcg 8641 gagactttaa tacaagccta gacgctatga aaaatagtgt tgggctaact gaccaggctt 8701 ttgaaacaat gaataatagt ttaataagta aatttgggaa aatgaaaaac agattaacaa 8761 atatggctac tgaaatgatg cagggaacag gtggacaatt aggagtttta atagatgaca 8821 taacaggtaa attaaaacaa tggcaggaag atgggactat agaacaggtt gctaataaag 8881 tggcgactgg atttatgaaa atgtatgaca ttattagtaa agttataagc tttctagtag 8941 agcataaaga tgcaatagca aatgtagcta ttgtatttgc atccttctat atagccatta 9001 aaattttcaa ggtacttaaa ggggttatat tcggagtaca gattgcaata ggattgctta 9061 atggtacttt aatgcttaca cctttgggat gggtcatggt ggcgataact gctgtaatag 9121 caataggatt attactatgg aaaaactggg ataaaataaa gcaagttgcc caaactttat 9181 ggacagcaat taaaacagta tttactaata tatggacaac aataacaact gtattcacta 9241 atatctggac cactataaca acagtggcta gtaatatatg gaccagcata acaactgtat 9301 tcactaatat atggacaaca ataactacta tatttacagc tatctggacc actataacaa 9361 caatagccac caatatatgg tcaagtatag tttctatttt tacaactata tggaatgtta 9421 ttgtaacaat atttacacct attaagttgt ttatagaagc ggtatggaaa ggcatattag 9481 ctgtaataat aattgtagga gcgtttattt ggaacgcaat tgtaacaatg tggactaacg 9541 tatggaacgt tatacaacct atactaacag ctatatggaa tgttataaca acagtatgga 9601 cagctatatg gaccacaata acaacaatag caatggctat ttggaacact atagtaaacg 9661 catggaatac tatagccgga gttgtatcag ctgtaatgtc tgcaatttgg ggtgttatat 9721 ctagtatatg gagcagtatt tatggaactg taagtggaat tatgtcatca atttggagta 9781 ctataacaga gatatggaac aatatcgtat ctactgttag cgatattgtt ggtaatatcg 9841 ctagtacaat aagtgatggg tttaattctt taatcggaac atgttccgat atattcaaca 9901 atataaaaaa tactgtaatg gatatttttc aaggcatatg gcaagggatt aaagatataa 9961 ttaacggtgg aataggtatg ctaaataatt ttattggtgg agtaaataaa gttattagta 10021 aagccaataa agttccagga gttaatatag gcgctgtatc ggaaatacct aaatttgcaa 10081 aaggcactca atattcaccc gcaggaatgg cactaattaa cgaagaaggt ggagagttaa 10141 gaaagctttc ttcaggggag acaattatac cagccgataa atctcgccaa ttaatgagcg 10201 ggaattcaag tccagaaatt aatatttata taactggcaa tgtaggaaca gaagagttct 10261 ttaatcaagc aggggaacat ataacaaatc aaattaaatt agcattgcaa aatatgtaaa 10321 ggtgtagttt tataactatg ccttttttat ttaagggggt gtaatatggc aaatatatat 10381 tttagtacat tagatagaaa acaattgtac gaacttccca ttttaccaga agaaatgccg 10441 gaacttagta agagtagtaa aaatgaaata tttgaaactt ttaacaatgg agaatataac 10501 ttcctaggag aagttagttt aatcagtttt agtttagaaa gttggttgcc agcatatccc 10561 aataagtata gatgggctaa gagccaaatt aatccttatt tattaataaa tatgtggaat 10621 acagcacaaa acactaagaa gcctcttagg attgttataa atagaaataa aaatactttt 10681 ttaccacaag aattattaaa ctggatggtt tctatagaaa atataagttg gcatgagcta 10741 accaatggag atgtagctta taaattagat ttaaagcaat acagggagat aaaataatgt 10801 ggtacttata tacttcctat attgtaggga aaggatatac aactaaagaa ataatagggc 10861 aatgcaataa tttaagttgg agcaatgacg tagatacatt agctacttcc ttgtcttttg 10921 attctatatt agatttagca gagggaagaa gtaaaataat attaagacaa gacaagataa 10981 cagttttcga gggcgttgta gtaaataaaa ataacaaaga aaatgtccac agctatacag 11041 ctatggacta tgcatggtat ttaaataaaa ataaatatgt aatgcaattt agaaatataa 11101 atgcgaaaag tgcattacaa cagatatgtg ctaaggtagg tattaaagta aatataagaa 11161 ctagattaac tactagaata aataaattgt atttccaaga aagtttaagc gatataataa 11221 aagacatatt agaacaatgt aaaagagaaa taggggaaca ttacataatg gaaatgcaag 11281 gtaaaacact ttatattaat agagttatag atttaaaaat taattcaact gtattaatag 11341 aaaaagatta tagtattagt agaagcatag aagatatgca aaacaatata atagcggtca 11401 ataatgatgg cagagtttta gccagtgtaa aagataataa aaatattaaa atattcggag 11461 aactaacgga cattataagt gtagaagatg aaaatacaag ccgagctaac aatatagcac 11521 gtaacgaatt aaaagaaaaa aataagataa aaaaagaact ctcttttaat acaatagata 11581 ctggcaaagg aatttatata aattgcaata gattaattag agttaatcta ggcaaatatg 11641 gtgtaaatgg gtggtataga ataaaaagca cacaacatac tttaaataat aatatacata 11701 aaataggtat aacaatagat tttagctagg aggttatata tggattatgg aatagaattt 11761 gcccaatggc taaaaaaaag aaataataaa gatagaatag ggacaacaat aggagaagtt 11821 gtaagaggag gtttggatta tagaataagt attatggata ataaattata tctagatccg 11881 agcaattcta ctttatgcaa ctctttaaaa gatagagtag aagaaagaac tatagaatta 11941 aataacacta gctacaatgc taaaataaca tatagtaata ttttaaaaaa atatgataaa 12001 gtgttggtta ttgaaaatga aagcggccag cactttttta ttgtagataa aatataggag 12061 gtgtgaatat ggcactactt ccagaagaag atataataat tgaagaagtg gaacaaatag 12121 aagaggaaca aactttgtct aagttaggca aggttttttt atttgatttt aaaaagaata 12181 aatatgtaat taaagatggg aaactagttg aatgtacaga acgacaagcg ttagagcaat 12241 ggatacattg gatattgcta acttataaag ataaatacaa tgtttacaag ggtacagact 12301 tctattgtaa tatagaagat ttagcaggaa agaaaagaaa tgcatttatt ctctcagaac 12361 tacaaagaga agttgaagaa gcagttataa agcatagata tgtagatcat atagaaaact 12421 ttgtaacaac acaagaaaaa tcaatattga atgtaagctt tgatgttgtt acaaaagata 12481 atgaagttat taatataagt gcctaggagg tgaagggttg agtgtaaatg taaaaacaca 12541 ggaaaaatta attaaagata tgcttaacaa catatcgaac acatatgaga aaagcgaagg 12601 acaccttaca tatgatataa ctaaaactaa tgccatagaa ttagctttac tatatcaata 12661 tgctttatct atagccaatc taaggttagt taaagaccta agaggtgatg atttaactgc 12721 aagagtctac gataataaag gcatagttag gaaagtagca acaagagcaa aagtaatcct 12781 aactctaaca gggacaggga ctattgataa agaggattta tttggtacac ctaacaagat 12841 agaatttgca agcctagaaa aaaaacaaat agaaggaaca ggaacaatat tagcagagtg 12901 tacccaagtt ggtaatatag gtatggttgg ggctaatagt attgcagaat ttccgataac 12961 aatagcaggc tttacagaag ttaataattc taatcccagt tatgatggtt tcgaggaaga 13021 aagtgacgaa tcacttagac aaagatatta cgaatcttta aagaacccaa taacaagcaa 13081 taaccaagcg cactttattt attgggctaa aagtgcgaca ggtgttggaa atgcaaaggt 13141 aatacccttg tgggacggag atttaacagt aaaggtaata ataataaatt ccgatatgca 13201 accagccagt gtggatttag tcaatacagt gcaggaatac atagacccca aaggaatact 13261 agataccaat acaaatacat ggagtttatg gggaactggt gctggtgcta gtgctatagg 13321 taattattgt actgttgtga gtgctacagc taaaaatata gatttagagt gttctatcac 13381 taaagccaat gggtattcag atgaagaaat aaaacaaaac atttctagta agatagcaga 13441 atatctaaaa gaaattgctt tttctgcaac tattaattat gtaagtcatg ctaaaataat 13501 ttctttaatc ctatctgcag atggggtgtt ggatgcaaca aatgtaaaag taaatggaag 13561 cttaagcgaa aacgtaatta taggtgaaga agaagtcgct acaatgggcg ctgtaacctt 13621 aatataagag gtgaaaagat gaatatagaa caacagttaa tagcaaattt acataaacgt 13681 gttagacaag attcttatgt gaaaaatttg tgcaacgcta gtggaattga aatggacact 13741 atagaagatg tcttagaaga tattaagaaa caatttaaat ttgaaacaat gacgtggagt 13801 gctgatttat tagcgagcga gatgggaatt aagttagacc catctttaaa gcaggatgaa 13861 aaaaatagta ttatagctgc tagatggaag tcagagggaa aggcagattt aaacttatta 13921 caagctatat gtaatagttg gaaaaatggt aatgtaaaag tatcttttat agatggtaaa 13981 atagtattta aatttgtggg cgaatatgga ataccggccg acctagatag tttaaaaaag 14041 caaatagatt tatccaaacc gtcacattta gctatagatt atttatttgc atacctatta 14101 ttaaaagatg tagaagaaat aaccttaaca aagttagaaa acactacatt aaataaattc 14161 gcattttagg agggattgaa tgagcaaaga aactgaaaat ttgaagttgt ttaaatacga 14221 tccagaaaca gatgatttta atacaacaac ttttaatgta acacaagctt taaataataa 14281 ctgggataaa atagatgcac atttagaaga tgcatcttca caattggctg atattacgac 14341 actaacaggt aataaagata acttaaaaac taccaataaa acaaatttag taagtgcaat 14401 taatgaggtt tttacttctg gcaataatgt aaaaattaat actgtagacg cattattgca 14461 attagataaa agtctacaga ttacaaaaga aagcaaatgg gaagatatta taaaaaacat 14521 tagtaaaatt agcacaggta aaaaatgggc acagggtaca gcaaatgtta actattatgg 14581 tcctgaagta ggaatattta tggaatcaaa ttatccttta tcttctgcaa gcgtaaatac 14641 aaattgtgga tttaagccat ctatcgtgat tttaacaaca ataggaataa ccccacgaac 14701 aaacccagac gattattttc gctctgatga taggtactca gaaccaagaa tagaattata 14761 tatttataat gaattattac aagtaaaaat tacatttaaa actaaaagcg gatacagtag 14821 cgatattgct tatgatcgtg agtatagtat tgagaaaata aattccattg gtaatacaat 14881 ttatacatct cttcatatta tgcgttatag tgtacgtgta gaaaaaggga ctagcacagc 14941 agaacgatat atgttcgata aagtaaattg gtatgcatat gaatagagag gagatgatta 15001 tatgaaaaga gggagcttaa ttatatatga taactcaggt aaagtatggg ttaatactgg 15061 tgatgcagag ggatgtattc ctccacatac accaccagat ggattacctt atataattac 15121 tgaatttgga gaatttaatg ataaaataat taaaggcata gatgtaacag ttacaccaca 15181 taaattaata acagaagata ttccacatat agaaacagaa gaagaaaaac taaaaaaaga 15241 attgttaaaa gcacaatcag aagtagttaa tttaaaatat aaagaagtgt taaataatat 15301 aaaatagaaa ggaaatgata ttatgatact atatgattta ttaaaaaatt taattgataa 15361 taattactat gaaaaggaag atatgaataa taaactaaat gtattctata cttttaacca 15421 gattgatata gaacagtata gcgagttaat ggctaaagtt aacccagctg caaaagaaaa 15481 tactatagaa aaagttgtta cacaatagat aaataaggcg acataaattt aaaaggtaaa 15541 gtaggcaccg aataggtgtt tttattttgc ctatttttaa ttactggagg gtgacatgga 15601 aaatgaaata attaaattag tagcaacaca aggagctttt gcagtgtttt ttgcatacct 15661 tcttttttat gtgcttagag aaaattctag gagggaaggg aaataccaag acattattaa 15721 agaattagca gaaaaattaa atgttataga agatgtaaaa aagacagttg ataaaataga 15781 gggtaaattg gaggggtaga atggatagag tattgaggaa aataacaagt gctagatggc 15841 ttatagctgt aataatgact atagtatttg ctatattagc aattaaaaac actttaaata 15901 cagaatttat aaccatttat acaatggttg ttgcatttta ttttagtaag gatagaaaag 15961 agcaagacaa atagttttgt tctttttttt atattaaatt ttagggagga atttatatga 16021 aaataggaat agattgtggt catacattaa gtggtgctga ttatggagca gtaggaataa 16081 aagcagaatc taatttaact agagaggtag gaacaaaagt tatagctaag ttaaaagcat 16141 taggtcatac agtcattaat tgttataagg atagttgtag tagtttaaat gatagtttaa 16201 gctatagaac caacacagct aataataaca atgtagactt atatgtatct attcatttta 16261 attgttataa cggtagtgct tatggtacag aggtttttac ttatggaggg aaatctttta 16321 cagaagcatc aagagtatta aataatattt gtgccttagg atatacaaat agggggttaa 16381 aagatggttc tggtctttat gtattaaagc atacaaaagc taaagccatg ctaatagaat 16441 gttgtttctg cgataatgca ggagatatga acagatataa tgctgaaaat atggctaatg 16501 ctatagttaa aggactagta ggtactacag tagcgacacc aaataaacca aaggaagtgg 16561 taaaagtgca aaaaccaaaa tatgatgaga ctataccaac aggagaaagt atatttaaaa 16621 ttccaggtac tactggatat atagagcaag ccacagacgg aagattgata atacataagg 16681 atagaggaaa ttatatagca atcggtaaag gctttataga ttgctattgg aatgataaca 16741 aaggcaatgg ctgtaataaa agattaagta attaattttt aaaggtactt ctataatgga 16801 agtacctctt tttttattgg aaaaattatt ataatttata taaatatttc ataaaaaggt 16861 attgatttat tatactatgc atagtataat ataagtatag taattgataa ggaggtgagt 16921 aagtgataga agatatagga aaactaatag ccctagtaat ttcaatacta acaatccgtc 16981 aactgagttt gcagaacagc aagacggagt tagaaataaa aaaactaagg ctagaaatca 17041 aaaggttaaa agagggggat taaacccctc aacctttcct atattatatc acaagtatat 17101 gaaaatatta aattatttat taataatatc aatcacaata atattattgt tgctaataaa 17161 actaacttat aacaaaagaa aaaaagctaa attagaaatt gaaaagcatg aaattgaaaa 17221 taaaaagggt gaggataatg gcaaagagta agcaaacaga agccaataaa aaatggtatg 17281 acaaaaataa agaacacgct aaatacttaa ataaaagatc acatacacga agttttataa 17341 aaaactttgc gaagctagaa gatttagaag aattacaaaa attaatagaa gaaagaaaag 17401 aattattaag acaagaatag gggattaaca atgaaaaagg aaattagatt cttaataata 17461 gggctgttgt taggagcttg cacaagattc atcggcattg caacagcgat tgaacaagcg 17521 gaagataact gccctagtaa tggagaatat atgtattgca cagaccaagg aaaaccacta 17581 tggatatcta tatatgacgt acatcaagaa gaaaaattta tctatttgcg acaaccgaac 17641 agtaataaaa taattaaatt aacacaatta aaataaaaac aaagaggtag ctttttaaat 17701 aaagctacct cttttaaatt gattgtaaca atatgtacaa aatttgaact ttatgtaaag 17761 acagtatata attattatgg aatatattac accacataga aaatttaagg gggttatgac 17821 atggagaata aaaaaaataa aaagccattc tataaaaaat ggtgggtatg gatattggca 17881 attattattt tagctggttt aggacaagga acaggagata agaagaaagc acaaaaaaca 17941 gcaacacaac aagagcagaa aaaagaagat gccaaacggg atgcagaaaa aaaggctaaa 18001 aaagaaaaag aaaagaaagc caaggaagaa gctgaaaaga aacctaaaaa agaagataac 18061 gaagctacac taataacaac tgcacaagga gttgttaaaa agaatttaaa agctccaagt 18121 acagcaaaat ttccgtggag ttttaaggag tacaatattc aagaatcaaa aagtgaaaat 18181 aaagatatga ttatatatac cgtaactgga tatgtagatg cagaaaatag ttttagtgcg 18241 aaaataagga ataattttat agttaaaatg gaatgtacaa aagatttaag caagtataga 18301 gtgttagatg taaacataac agaatagaaa acagagattt aaaaagataa aaaccgtact 18361 aaaagcgtac ggtttttatt tggtttcaca cgagaaataa agaaaaagtc gcgaatacat 18421 ataatgaaaa taaggtatat caatgtgtat tgagctatgt taatccttaa tcgttcaagt 18481 ggagtgataa cacttttaaa tattgcttat gagctaaaaa ataatgagag tttaaagggg 18541 aaggcagaca aaataaaaat agtattttta gataacgagg aaagcggctt gttaggatct 18601 aatttactat caaaatattg gcaagaaaaa gatgaatatt ttaaagagaa aaaaataatt 18661 aattttgatt gtgtgggaat aggggatata cctatagttt attattcaaa ggaattagat 18721 tatgagttag ctgacttcct gcgaaatatt ttaggttatt atgaaaagaa cagtaagaaa 18781 tttatgtgta aatattatcc attgtctgat gactattcct ttaaaaaaaa tccagctata 18841 agtataattt tttctaataa cagcataata ccagggggat attatattcc taatgtacat 18901 tgctcaaaag ataatgtttt aaaattagaa aatattcaat ggttaacaag agaaatattg 18961 aaaaaaattt aatttgttat aggtaatttt tgtagtttta caattaaaat aaacactatg 19021 aaaatctatt agatatatag ttcacagtgt tttttattat atttagcttt atctaggtat 19081 catatagaaa agtgagaaaa agtgaaaaac acttccacct attacaaata aatgccatat 19141 tgggtggttg taaggtatat catctaacat aaaaagaaag gctccaacag tataaataac 19201 tccacctact ataagatata taagggatat tctaggtata actaaaacta attttttagc 19261 atgaagcatt ataagccaac ccatgaaaat atatatagca gtggatagtt tttcgtattt 19321 accagttgta aatactttta aaatgattcc tattaaagta aggccccatt ctataccaaa 19381 tatagtccaa cctaaaggat ctctaagaga ggtaagtata aaaggggtat aggtacctgc 19441 aattaaaaga aaaatagagg aatgatcaaa gatcctaaat atttttttta ctttgctgcc 19501 ctggagacta tggtataagg tagattccaa atataatata aaaaggcatg atccaaatat 19561 gctgtaactt gatacatacc aagcatctcc atacttagct gaaaatacaa ttaaaataac 19621 taaggcagct atagataata aagcaccaat accatgagtt atagcatttg ctatttcttc 19681 acctttagta taaaattcat ttaacataaa catatctcct ttttaagaat atatattata 19741 ttatactata atggtaaaag tatgtactat acattaataa aaaatcacca ttgctaacca 19801 atagtgattt tttattaatg agatagatta aacgttaaat ctaaagttta caatatctcc 19861 atcttgcatt acatattctt ttccttcaag tctaaagaat cctttttctt tagcatgggc 19921 ttcagaacca cattctataa gtttatcgta ggatataact tctgctctta taaaaccttt 19981 ttcaatatca gtatgaattt taccagcagc tttaggtgct tttgtacctt taactatagt 20041 ccaagctcta acctcaactt gacctgcagt taaaaagctt ataaggccta ataatttata 20101 actagattga actagtttat caaggccaga ttcttttaac ccatattctg aaagcatttc 20161 agctttttca tcatcttcta aagttgacaa ttcttcttca agtcttgcac ataaagttat 20221 cacttcagaa ttttcagctt ttgcaaattc tttaactttt ttaacaaact cattttcagg 20281 atttccagac attaaatcat cttcagatac attagctgca tataaaacag gttttgaggt 20341 caaaaggaaa taacttttaa ctaatttctc ttcatcttct tcaagttcca acgttctaac 20401 aggcttacct ttttctaaat gagcaactat tctcttcatg agagcttctt ctgttttggc 20461 ttctttatta ccacttttag ctagtttact atttttttca attcttcttt gcattaattc 20521 tatatcagaa aatataagct ctaaactaat agtttctata tcacgaatag gatctacaga 20581 gccatctacg tgtactatat ttgaatcttc aaaacatctt actacatgaa caatagcttc 20641 aacttccctt atatgagata aaaatttatt tcctaatcct tctcctttac ttgctccttt 20701 aactaatcca gcaatatcat aaaactcaat agcagtagga accttctttt tagagttata 20761 cattttttct aaaacatcta atcttttatc tggtacacta actaccccta cgtttggttc 20821 tatggtacag aatggatagt tagcagattc agctcctgct tttgttattg cattaaataa 20881 tgtactttta cctacgttag gtaaaccaac tattcctaat ttcatattat gtacagtcct 20941 ttctttgtat attgacttta tgtaattaaa aaaatctaaa taattgataa aacaatttat 21001 atttgaataa aaataattta ggttatttta tcaacttata aacacagtta gatcttgtaa 21061 aaaattagtt tttataattt cctattaaat tatactaaag gctaaagttt atttcaagaa 21121 tagagcggtt atattatgca ttttgaaaat ataatttaaa gaatagtaaa tcaatatatt 21181 aaatcttata aaaggatatt tttattgggt ctatagtttt ttataaataa ataggtaggt 21241 ttatataaat ttttaaataa ttagaaaagg ttttgaaagt gtaataaaaa tagaactatt 21301 atagtaaaat agcatgttta ttttatttgg gtatatataa tataggatat gaaaaatatt 21361 ttatcaaaat atgtctaaaa attaatagaa tattagataa aattttgttt tttttgtgat 21421 tatgctttat ataaataagg ggaattttct tgaaaaaaca aattatattt cagaaaactt 21481 aataatatga ctgttaaacc ttattttact aatcttatta atattttaaa ttaatttaaa 21541 aatcgaagtg aaaatattta agttaataga aggaatttta atgagaatat agaatattaa 21601 ccttaatagt ggtttaaagt ggttcaaagt ggagcgaaaa ttaccaattg gggtggagat 21661 atgtttatag gggagtataa tcatggcttg gatacaaaaa atagaattat aatcccggca 21721 aagtttagag aggaattagg aaagaacttt gtattgacta aaggattaga tggatgtctt 21781 tatgtatatc ctaaaagcca gtgggaagtt cttcagaaaa aattagaaac tctaccttta 21841 accaataaaa atgctagagc ttttgtaaga ttctttttct caggagctca tgagttagaa 21901 ctagataaac aagggagaac attaatacca caaaaccttt tagaatatgg acaaatacaa 21961 aaggaaatag taagtatagg agtttccaat agaatagaaa tttggagtaa ggaaaaatgg 22021 gaagaatata ataattctaa tatagattat gatagtatag cagagcagat gagtgaactt 22081 ggaatatgat tatttattat attttaacta tttagattta atcttaatta taaaataagt 22141 gtaaatgcat tacattagga ggatacacat ggaatttaaa catatatctg tattattaga 22201 agagactata gattcactta atataaagga agatggtgta tatgtagact gtactttagg 22261 tggtggagga cattctaaag aaatattaaa aaaattatcc cacaagggaa aattaatagg 22321 catagatcaa gatacaagtg ctattaaagc agctaaagaa agattaaaag attatgagaa 22381 tgtaatttat gtacataata atttttataa tatagatagt attttagaag agctagatat 22441 agataaagtt gatggtataa taatggattt aggggtatct tcttaccaat tagatgaagc 22501 ttcaagaggc tttagttata tgaaagatgc acctttagat atgagaatga atagagaaga 22561 aaatctttca gcctataatg tagtaaatag ttatgaggaa gaagaattgt ttaaaatatt 22621 aaaaaattat ggagaagaaa aattttctag aaaaattgct agatttatag tagaaaaaag 22681 aacagaaaat cctatagaaa ctacagggga attagtagaa ataataagaa aagctattcc 22741 agctaagttt caaagagaag gacatcctgc taaaagaacc tttcaagcta taaggataga 22801 agtaaacaag gaacttcaaa tattaaataa agctatagaa gacagtgtaa atagactaaa 22861 taaagatgga agattaagca taataacctt tcattctttg gaggatagaa tagtaaaggt 22921 gaaatttaaa gaactagaaa aaccatgtac ttgcccgcca agtttcccaa tttgtgtctg 22981 tgggaaagag ccacaaataa aaataataac aaaaaaacca atagaacctt caaaagaaga 23041 aaaagaaatt aactctagaa gtagaagtgc aaaactaaga gtatgtagaa aaatataaat 23101 atatgagttt aatgctttta aaaattttat atctaatact ttaaaaatat agttataaaa 23161 cagagggagg ctgaataaat tggtaatgtt agaagcaaaa aacagattca atgggaatac 23221 agttttaaag ccacagtatg aaccacagat agaaaaggat aaagtgaaag agaaaaaaga 23281 gcaatacaaa aggaacaaaa aaatacaaca aaagctttta aaaaagaaat tcaaaacttt 23341 aagaaatatt atcatagctt ttataatagg ggttacttta gttgctagat acggaatact 23401 ctatagtatg caaaaagatt taagtaatat aaatagccat atatcagaag tagaaaaaga 23461 aaatgaaaat ttaaaagtgg agttagttca ttataataat ttaagcaata tagaaaaagt 23521 agcgggacaa aatcttaaaa tggtaccccc tgataaggat tcagcaatat atacggattt 23581 aagttataac aactttaaaa cagaaaattc taaaaatcat attggagaaa agcataatgc 23641 ttttttagag tttttttcta atttaaagaa agtgctattt taaatggagg taacataatt 23701 gtcaaatagt aagtacagag acaaagtaat aattagaaaa agaatgatgt ttatatttgc 23761 tcttctaatt ttagctttta taggtttagt aataaaaatg ggaactataa tgataggtca 23821 gtctccagag ttgaaaaaaa aagctgtgga tcaatggaca agtgaagtaa aaattgatgc 23881 taaaagaggt agaatattag acagaaatgg taatgaacta gcagtaagtg ctaatgtata 23941 cagagtagat ttagatatga atactttaag aagtaccatg gaagaaaaaa aactatctaa 24001 aaatgatgta gcatcaaaac tttcaaaagc attagatatg gaacaaaaag aagtagaaaa 24061 agtattgaat aaaaagcttc caagtggatt acctttagcc tctgctactt taaaaagaag 24121 aatagaaaag gacaaggctg acaaagtaag agagctagat ttaagaggga ttttagtatc 24181 tgcggacact aaaagatact atcctaataa taatttttta tctcatgtat taggacatac 24241 aaattctgat ggaaagggac ttacaggagt agagttatac tataacaata tattatcagg 24301 taagccagga gtaaggattg ctgaaacgga taataaaagc aaggaattac cttataccat 24361 ttcagaatac actaaaccag aggatgggaa agatttagta ttaaccatag atgaaatgat 24421 acaacacttt agtgagaaaa cagcagagca agctttaaag gataacaaag caaaggcagt 24481 atctgtagta gtaatggatc ctagaactgg agaagtacta gctatggcaa ataagccaga 24541 ttataatcct aatgatcctt ggcaggaagg gaaaagctat gaagaacttc aacaaaactg 24601 gagaaataga tcggttaatg atacttttga accaggatct gtatttaaag tttttacggc 24661 agctaccgct ttagaggaaa atttaataac ctccgaggat aagtttactt gtggtggaag 24721 cataactata gggaaaagaa ctatacgttg ctggaaaagt ggagggcatg gtactcaaaa 24781 ttttatagaa atacttaaaa actcttgtaa cgtaggtttt gcacagttag gtcataagat 24841 aggtaaagaa aaattaaatt catatattca aaaatttggt tttggtaaaa aaactggtat 24901 agatcttcca ggagaagctc cagggataac aaagaaaacg gaaaatatat cagatataga 24961 tttagctaca atatcctttg gtcaagctaa cacgttgtct atagtacaat atctccaagc 25021 ctttaatgca gtggctaatg gaggaaatct tataaaacct catgttatga aagaagtagg 25081 acattttgat gaggaaaaaa ataaagaaat aatagaaaag aaaaatacca tagaaagcaa 25141 gcaaatttta aatagtcaaa agatggctac cctaagaagc tacttagaaa aagtagtgtc 25201 agaagggggc ggtaaaaagg cttatatagc aggttatcat ataggtggca aaactggtac 25261 agctcaaaag gctggtaagg gtggatatat gcctggtaaa tatgtagctt cctttgcagg 25321 aatggcacca gctgataatc caagaataac agtatttgtt tctattgatg aaccggatcc 25381 ttcaaattac tatgcaggcc aaatagcagc tccagcagca caggggctat ttaaagatat 25441 atttaattat ttggcattaa aaagtgatgc ccaaggggaa gatatagcta aaagtcttct 25501 aaaggatata actattcctg aagttagagg taagtcaaaa gaagaagcac aaaaaatatt 25561 aaaagattta aaattagatt gtgagataca atctgaggga gaatatatag tagatatgaa 25621 tcctaaacca gggtatactg taaaagaagg cagtaaaatt gttctttaca cagggaacag 25681 tcaaaattat aataaagtag tagttgttcc gaatgtaaaa gggtatacag tagaacaggc 25741 catgtctgta ttaaatagta taggcttaag aggggatata cagggtgatg gaattatttc 25801 tcatcaaagt atagaagcaa ataaggaagt taaaaaagga actatggtta acttaaaagc 25861 agaaccaata ggagattaat ataataaaaa attggcatgc agtaatacag ggttctgtgt 25921 attgcatgct aatattttgt tagttctaca tagataattt agttaataga ctttaaaaaa 25981 attacataag aaactataat aaaataagga tatataaata aaaaataaag ttttttattt 26041 acaaaaatta aatatggttt tattgttatt atattaagtg acaataatta agataaggaa 26101 gtgttacaat gaatttaaat ttaatactaa agtcattaga atattctttt ataaaagaaa 26161 ataaaaagga aatagaaaag atagaatatg attcaagaaa agttaaagaa ggagatttat 26221 ttgtttgtat agagggatat gcaacagatg ggcataaata tgcgaaaaaa gcttatgaca 26281 atggagctaa agtaattgtt tgtgagaagg atttagaaga cttatcctat tataaagatt 26341 gtactataat aaaggtttca gatagtagaa aagccttagc tataatgtca tctaattatt 26401 atggtaaccc atctaaacat attaaaataa taggtattac aggaacaaat ggcaaaacta 26461 catctacttt tatgatgaaa gctatactag aaaaagcagg ctataaagtt gggcttttgg 26521 gaactatagc aaattatata ggaaataaaa aaatagaatc tcatagaact actccagagt 26581 ctctagaact acaaaaatta tttaaagata tggtggatga aaaagtagat tattgtgtaa 26641 tggaagtatc ttctcattct ttatatttag atagagttta tggagtagaa tttaaagagg 26701 ctatatttac aaatttaacg caggatcatt tggacttcca taaaaccttt gaaaattatt 26761 ttaattccaa actaatttta tttaaaaatg ctcaaaattc agtgataaat atagatgata 26821 gttatggaga aaaagtatta aagaaagctt taggaaataa aataacctat ggtgtagaga 26881 aaaattgtga tttaaaagcg gaaaatttac atatgcattc tagaggagta gaatttgata 26941 ctatatttaa aaatgaaaaa gaaactatag ctttaaatat accaggtaaa tataatatat 27001 ataatgcttt aggaagtatt ggagcttgtc ttttggaggg tattccttta aaaactataa 27061 aagaagcatt agaagatatg ccatctgtac caggaagatg tgaaattgta actaaaaatt 27121 ataatttagg ttatgatgtt atagtagatt atgcccatac tccagatgga ttagaaaata 27181 tattaaatac tgctcgagaa tttacaaagg gaagattaat aagtgtatac ggatgcggtg 27241 gagatagaga tagaactaaa agaccaatta tgggaaaagt ggggtcaaat ttaagtgata 27301 tagctataat aacctcagat aatccaagaa cagaggatcc taaacttata ataaaagatg 27361 tattagaagg tatagaaaga gataactata tagtagttga aggaagacga gatgccataa 27421 gaaaagctat ggaaatagca aaagaaaatg atgttatagt agtggcagga aaaggccatg 27481 aagattatca aatattaaag gataaaacta ttcactttga tgaaagagaa gtaatagaag 27541 aactaataaa agaaatataa //