LOCUS NC_009749:10 18743 bp DNA linear BCT 06-OCT-2011 DEFINITION Francisella tularensis subsp. holarctica FTA, complete genome. ACCESSION NC_009749 SOURCE Francisella tularensis subsp. holarctica FTA, complete genome. COMMENT locus start: 1776600; locus end: 1795342 FEATURES Location/Qualifiers source 1..18743 /organism="Francisella tularensis subsp. holarctica FTA, complete genome." gene complement(0..578) /gene="" /locus_tag="" /db_xref="1776600..1777178" CDS complement(0..578) /gene="" /product="hypothetical protein" /translation="MYNVVKFGCQERPEISSVEEPTKPLAIQDKKTKGNVMTFWRQKL TYVGCGEERSVTLHYFIYNNENPKKVYYSIKAKNDSIPLNKTIFEGSFTSLVLRNDVL NDVVRFLYSKKCSMPEDKLRDHIKYYTASALRYALILSNQKRIKVPQWQEVWSVDACD KNYHFPITFTGDGVGGTYWSIGKVTDTEITKS" gene complement(612..1910) /gene="purB" /locus_tag="purB" /db_xref="1777212..1778510" CDS complement(612..1910) /gene="purB" /product="adenylosuccinate lyase" /translation="MIKRYDIAEISKIWADENKYAKMLEVELAILEALEDRMVPKGTA AEIRARAQIRPERVDEIEKVTKHDIIAFCTSIAEQFTAKTGKFFHFGVTSSDIIDSAL SLQIRDSMSYVIKDLEALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVE FKRRLKDLKDFQKDGLTVQFSGAVGNYCILTTEDEKKAADILGLPVEEVSTQVIPRDR IAKLISIHGLIASAIERLAVEIRHLHRSDVFEVYEGFSKGQKGSSTMPHKKNPISTEN LTGMARMLRSHVSIALENCVLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNL VVQRDIIEDRVRSTSAYLSSFYLHFLVANTPFMREDCYKIVQQVAFDLKQGESFSKKL QKVMHDEHNIILYIPEMDFEGIKKTYLKEIDHVFDRSVKA" gene complement(2083..2739) /gene="" /locus_tag="" /db_xref="1778683..1779339" CDS complement(2083..2739) /gene="" /product="transposase (IS4 family)" /translation="VLRTGCQWRMLPFYYGKYRSIHKRFKDWCDKDIFSRLFKSVQNP DLQEVMLDSTIARAHACATGYDKDDNQAIGRSVGGITTKIHAMTDALGNPIEILLSEG KTHDSKVANLLKNVYNTKVIADRAYHSNEIRQHIQSISSEAVIPCKSNTLNHIPFDSH VYKERHLIENFFSKIKHFRRVFSRFDKTISEYIGMIKLACTFIWLLRNYFCAQNLVKP" gene 3096..3494 /gene="" /locus_tag="" /db_xref="1779696..1780094" CDS 3096..3494 /gene="" /product="hypothetical protein" /translation="MKKLIVTSTFITALVSVSYATELKGSDYISTEVGSTYNYQRVNA DDQDKFTIETTIKSCNNAKTSCDYVSQIKDVNGKTSANSSYQYSYVVSADGAVYITYP NSQQQTLLLPAKIEFNKIRNDNVINADTNS" gene 3832..4518 /gene="" /locus_tag="" /db_xref="1780432..1781118" CDS 3832..4518 /gene="" /product="hypothetical protein" /translation="MQPNTQYLYKRTALKADKSIFIDIDIQSCNSDQSKCQYFVSVKS DKDKILEQYYETYYVNFFGDVYLTDSLYPNGTLILPARIRLGEELLLDNGDNYGLVQE KLLAYKLIPEIQVNNHEYKNCVNILFETTTPTETVDLKLVTDEITCKGIGSVRKEMQM SYKPKFANTNTEDINNSIMKFAATKSISKDMAPEGSLKPSGQKNVELNTQDYILIDTY LDILQAITHK" gene complement(4536..5366) /gene="" /locus_tag="" /db_xref="1781136..1781966" CDS complement(4536..5366) /gene="" /product="hypothetical protein" /translation="VEISELGAEVRAVINTSTEHGYMWSGDGCVWAGVSPVLFPVVGK SHDNKIKYQGKEYPMGNHGLARHTVFDIVLHSENSVILAMETSKEDYPFRLRFEVTYT LEVNKLITEYNIINLDDGVASCGFGAHPAFACPFYDKHKFSDYEITFSEQKLDFHPIT PEAFYTGETKHFKLSKIELDNHTFDNDALVYSGFTDKRVRLAEKGSNRYIEVTFDGFE YLGLWSKPKANAPYVCIEPWCGRSDTLGMDVNIEYRIGNVDIEPQQNFSRSYTIEFGY" gene complement(5681..6295) /gene="" /locus_tag="" /db_xref="1782281..1782895" CDS complement(5681..6295) /gene="" /product="type II restriction enzyme MthTI" /translation="MIKGGDAIEVKKTQSANSSLALNSSYPKADLRSSSQMITNECRA CEDWDIKKLIYCVGHTDDSELKSLWMVYGSIYAAKQETYERIRNTISDGIKEVPDVVF SETKELGRVNKVDPLGITNLRIRGMWQIENPRKVFDYLHAQGSNKFELICIIPLANYQ KIPDNSRNSFEKLKVDGLNVEDKKVRDPNNPAKLIDCKLVKFII" gene complement(6326..6571) /gene="" /locus_tag="" /db_xref="1782926..1783171" CDS complement(6326..6571) /gene="" /product="type II restriction enzyme NgoPII" /translation="MYQITNMQAEREESDLTNILEAIANIVKYRDYSIKQMYTGRNRA NSVGDALEKYIKDAFAGTLGSEHSEEDKLNIYSEKFS" gene complement(6523..6858) /gene="" /locus_tag="" /db_xref="1783123..1783458" CDS complement(6523..6858) /gene="" /product="modification methylase HaeIII" /translation="MSRNRVRSWDEQSFTIQAGGRHAPIHPQAPKMEFVEQNHRIFVP GKEHLYRRLSVRECARIQTFPDNFVFYYDKVAAGYKMIGNAVPVKLAEFLAKCIKLQI CKQNERKVI" gene complement(6840..7175) /gene="" /locus_tag="" /db_xref="1783440..1783775" CDS complement(6840..7175) /gene="" /product="modification methylase HaeIII" /translation="MLAPRHTEALTNIKQMFEDAGYNLSFKLLNSSDFKVPQDRQRVF FVGIRKDLGFNFNFSTNTYPKITLKDAIWDLRESVIPALPLNNTNGDGCKVTNHEVVF HLFICLGIE" gene complement(7316..7513) /gene="" /locus_tag="" /db_xref="1783916..1784113" CDS complement(7316..7513) /gene="" /product="modification methylase HaeIII" /translation="MKVVSFFSGAGGLDLGFERAGFDIIWANEFDKEIWETYEKNHPN TILDRRSIVNIHESEFLIVMV" gene complement(7513..11385) /gene="purL" /locus_tag="purL" /db_xref="1784113..1787985" CDS complement(7513..11385) /gene="purL" /product="phosphoribosylformylglycinamidine synthase" /translation="MITIFEGLSALSPFKREKILAAAKKISNKVESVSAQYIHVTELE SELNSEQERIVKSLLNYNREYGIAQPMGHTFIIAPIVGTISPWSSKATDIIKNTGIKA VKRIERAILFGVEGQVSASELKQIQDIVHDRMVEEVFSCKDDLYRLFSVTAPKELEFV NVLEKGAQAIKEADRKLGLALSEQEIEYLADEYTKLGRNPTDTELYMFAQANSEHCRH KIFNAKWTIDGQEQDKSLFKMIRNTTEKSPQGVLSAYKDNAAVIEGATAQRFYPNTQN GVYSFNQEEVDILMKVETHNHPTAIAPFSGSATGVGGEIRDEGATGLGAKPKAGLTGF TVSNLNIPGFEQAWETSKYGKPNHIVTPLQIMLEAPIGGAHYSNEFGRPNLNGYFRTY EQEVNTSAGKEMFGYHKPIMIAGGMGNIKRMHVEKGDIKVGAKLICLGGPAMRIGLGG GAASSVVSSDTNSELDFASVQRDNAEMERRCQEVIDRCWQMGENNPITFIHDVGAGGI SNAFPELVKDGGVGGYFELRKVNVGEEGLSPLEIWSNESQERYVLSVDPESLELFEQL CNRERCPFAVVGEAISEKHITLNDEYFDNKPVDLPMGLLFGNTPQMHIDVKTVKVEQQ AFDTSAIKLDEAIEKVLKVPAVASKSFLITIGDRSITGMVARDQMVGPWQVPVADCAV TTATVDSQAGEAMAMGERTPVAAINAAASGRLAIAETVTNLLAADIEKLSDIRLSANW MVAANQGDENQKLYETVRAVGMEFAPALGIAIPVGKDSMSMKTKWSDNGQAKSVTSPL SLVISGFSPVTNARKTLTPVLVDDNDTTLLHIDLSNGAGRLGASCLAQAYNQVGNVAP DIEASKVKVLFENITKLKAENKILAYHDVSDGGVFATLAEMSFAGRKGLDVKLQTQDV LAKLFAEEVGVVIQVRNSDVSLVEEMFKDTQIHLCAIAKLNSSDELNIFANGEKIYSN TRVNLQRWWAETSYQIQSIRDNSECAKQEFDSILNTNDKGIHVEATFDLEEDITAKFV NVEKPKVTILREQGVNGQVEMAAAFTTAGFEAHDVHMSDLHAGRVTLADFKVLVACGG FSYGDVLGAGGGWAKNILFTEKLRDEFSRFFGRDDTLTLGVCNGCQMLAQLKSLIKGA ENWPIFIKNKSEQFEARVSMVEIQESDSIWFADMACTKAPIAVAHGEGRPLFENDNQQ QAMLASAQVALKYIDGQGQATEMYPYNPNGAVNGLTAVTALDGRVLAMMPHPERVYRA ITNSHIPAEYDEYSVWMRMFRNARKWVG" gene complement(11385..12875) /gene="purF" /locus_tag="purF" /db_xref="1787985..1789475" CDS complement(11385..12875) /gene="purF" /product="amidophosphoribosyltransferase" /translation="MCGVIGVAGPDQVSYALFYGLSLLQHRGQDAAGIATMDHGHFFI RKNTGLVSDVFTDEKLEKSKGNMGIGHVRYPTAGSLGAADSQPFYVNNPHGIVFVHNG NLTNVPELAQMLHDIERRHLNTSSDSELLLNFFACGMNKSKGSATSEAVYKACKFVFE HVKGGYACTAMIANFGLIAFRDPYGIRPLVLGFKEYDDGEKAYMVASESVALDISGFK VLRDVEPGEVIIITEDRKVHSKICAKNPVLAPCLFEYVYFARPDSIMNGVSVYQARVD AGKILSKRIKEAWKDKDIDIVIPIPETGRASAQEIATALGVEYREGFVKNRYVGRTFI MPENVDRKNFVRRKLNPIPAEFRDKNVLLVDDSIVRGTTSKRIIEMIRDLGAKSVYLA SVSPAVRYPNVYGIDMPVKSDLIAHGKTIEEIRQWIGVDGLIYLPLEDLKEIIQKQNP KIREFEDSVFSGNYITGDVDDAYLDVLEKHRKELKELEKKYKGFDN" gene complement(12969..13178) /gene="" /locus_tag="" /db_xref="1789569..1789778" CDS complement(12969..13178) /gene="" /product="glutamate decarboxylase" /translation="LIYLRVRAKGWQIAAYTMPNNREDLVVMRVLVRRGFSYDLAQLM IRDLVVVIDSLEGKLKILKRSSFAH" gene complement(13153..14064) /gene="" /locus_tag="" /db_xref="1789753..1790664" CDS complement(13153..14064) /gene="" /product="glutamate decarboxylase" /translation="MIALIKIFDKDEYPQTAEIESRCVNILANLWNSSAENAIGCSTT GSSEAAMLGGMAMKWRWRDKMKAQGKDYTKPNLVTGPVQVCWHKFARYWDIELREIPM SNESLIMTPEAVLERCDENTIGVVPTLGVTFTGQYEPVEQVCKALDDFERQTGVDIPV HVDAASGGFLAPFVEPELKWDFRLPISPLGVGWVIWADKKYLPDDLIFNVNYLGGNMP TFALNFSRPGGQIVAQYYNFVRLGFEGYKKVHQLCYDIAEYIAKELRKMEIFEIIHAG EGGIPAVSWSLKATKEYSLFDISESSR" gene complement(14039..14272) /gene="" /locus_tag="" /db_xref="1790639..1790872" CDS complement(14039..14272) /gene="" /product="glutamate decarboxylase" /translation="MALHGKKDTIDNLDFFEQSLPKFKLPLNSQDPLEVYQEIKDELM LDGNSKQNLETFCQTEVDDFIHKLMDDCIDKNI" gene complement(14283..14924) /gene="" /locus_tag="" /db_xref="1790883..1791524" CDS complement(14283..14924) /gene="" /product="4'-phosphopantetheinyl transferase superfamily" /translation="MPQVSAFILDFEKYKAEDLRGYLCCRNIDSARFNNKQKIFSQFV RYFVLEEFYHISSPIFLNQHGKPYLADNSVFFNISHTQTKLIIAVADQEIGVDIEKLS ARRNIIRIAQRYFTSLENQWLAASDNPVKDFYTLWTLKEAQVKRDSLGIAKGLSGANF SKINDSWLSNSYPDDFVTFSYDESIVSICCKNIVAQKINLFEIVDFKFKQIQL" gene complement(14933..16462) /gene="" /locus_tag="" /db_xref="1791533..1793062" CDS complement(14933..16462) /gene="" /product="outer membrane protein TolC" /translation="MKKLTLYLLGFLGFCLALANEDTPVPEYKYAGRPIGTDVAENPY SVEKQYAKADQIKVDNKFYNLKKADEVAMVGDTEDKYYSLIDIYKLSAEHNADYQAAR STFAANVETVPTALGALLPQIDFNYNLRRDLYNQFGGRVNDTSNVVNFSGSQVLFDWS KWKTYTQATYLQKSYAMIYAKAEQTLITDTITAYFELLRAEQALQFQFANEAWNKKLY LTQKYQYNSGMVSYADFKTTDAQYRQAIADRVNAQRNFINAKAVMAKLIGKRISSILY ISKDTEFGNPVPDDINYWLNTAEKYNLDIAQKKFEYEAAQEGVGIQWGKFFPQANLTG GIMMSRNALSGSPAQIAEIPTKYDVANIGGQVSWNLLRGGSDYAQLKQASYDNQAANY ALLQTKREVYAGTVEAYQTVVLDAVRIEAFRKSVYSGIASVKAILEGFEAGTQTIVDL LNRQAILVQAQLSFADAIFNYVEDYVSLKQLQGSLTYKDIEYINTILGTTDIISQIAT E" gene complement(16471..17091) /gene="" /locus_tag="" /db_xref="1793071..1793691" CDS complement(16471..17091) /gene="" /product="protein-L-isoaspartate O-methyltransferase" /translation="MNFELARENMVKQQVLTEGLSLDGVAKVMADIPREIFLPRELQT LAYCDTNLVVNERELRSPMFTARLIEALAIKVSDNVLKLGLESGYPVALIAKLCKSVE LVDYDELGLAVARRQLASIGIYNVEFNSAEHITNIIKNGKKYNCIYISEVVTEDEIDE SLLGLLETGGRLIFVVRTAICDKAYLITKTPKQTYEKSFLFNTYNK" gene 17411..18742 /gene="" /locus_tag="" /db_xref="1794011..1795342" CDS 17411..18742 /gene="" /product="peptidase U32" /translation="MKRPELLSPAGTLKAMRYAFAYGADAVYIGQPRYSLRARNNEFS KLEILETAITEAHAQGKKIMLANNIAPHNAKIKTYIKDITPVIALKPDAMIMSDPGMI MLVREHFPDQKIHLSVQANAVNYETVRFWQKFGIMRVVLSRELSLKEIAEIKENVPDM EIETFVHGSLCMAYSGRCLLSGYYSHRDPNQGVCNNACRNNYKVAEAKQNEWGDFEPI QTQSTLGIGTPSDKVVLIENDKEPGQYNPMFEDEHGTYIMNSKDLRAIQHVETMMKMG VDCFKIEGRTKSFFYAARTAQLYDQAIKDALAGKPFDMTLMDKLEGLAHRGYTEGFYR RHVHDEYQKYDNSDSRSSTQQFVGEITNFDAHTGYADVNVRNKIKIGDSIELMLPSGS REIILDNMQDKDGKHMEEAKGSGYQAKIKFDNVTAEDMKFALMIKNKSPNI" ORIGIN 1 ttaagatttt gtaatttcag tatcagtaac cttgccaata ctccagtatg ttcctccaac 61 accgtctcct gtaaaagtga ttggaaaatg gtaattttta tcgcaagcat ctacactcca 121 cacctcctgc cattgtggaa cttttattct cttttggtta gataaaatca aagcatatct 181 taaagcagaa gcagtataat atttaatatg atcccttagt ttgtcttcag gcatgctaca 241 tttcttagaa tataaaaatc taacaacatc gtttaacacg tcatttctta atactaatga 301 agtaaaagat ccttcaaaaa tagttttatt taaaggtata gaatcattct ttgcttttat 361 agaataatat acttttttag gattttcatt attatatatg aaataatgta acgtcacact 421 tctttcttct ccacagccaa catatgtaag cttttgtcgc caaaaagtca ttacattacc 481 cttcgttttt ttatcttgta ttgctaatgg ctttgttggc tcttctacac tacttatttc 541 aggtcgctct tggcatccaa acttaacaac attatacata aataaaaaga aaagataata 601 tttttttcat atttacgcct taacagatct atcaaaaaca tgatcaattt cttttaggta 661 agttttcttg ataccctcaa aatccatctc tggaatatat aaaataatat tatgctcatc 721 gtgcataact ttttgtaatt tcttcgagaa agattctcct tgtttaagat caaaagcaac 781 ttgctgaaca atcttgtagc aatcttcacg cataaatggc gtatttgcta ccaagaaatg 841 taagtaaaaa cttgataaat aagcactagt acttctaacc ctatcttcga taatatctct 901 ttgcacgacg agattatcga tagtattttt cattctacgt aaagcataaa ccataatacc 961 aaagttatct ggcagataaa aacgctctgc tgaagagtga gaaatatctc gctcatgcca 1021 tagcacacaa ttctctaatg ctatagatac atgagatctt agcattcttg ccatacctgt 1081 taagttttca gtagaaattg ggtttttctt atgcggcata gttgatgagc ctttttgccc 1141 tttagagaag ccttcatata cctcaaaaac atcactacga tgtaaatgtc taatctcaac 1201 tgctaatctc tctatagcag aagcaataag tccgtggata gatatcaact tagcaattct 1261 atctcttggg ataacttgag tagaaacttc ttcaacaggt aaacctaaaa tatcagctgc 1321 ttttttctca tcttctgtag ttaaaataca atagttacct acagctcctg agaactgtac 1381 tgtcaaacca tctttttgaa aatctttgag atcttttagc ctacgcttaa actcaacata 1441 agcaccaaga aacttctgac caaagctcat cggttcggca aacataccat gacttctacc 1501 catcgtaatg atttcttttg tttcttctgc cttagtaagt agcgagtcac aaagcgcctc 1561 taaatctttg ataacatagc tcatagaatc acgaatttgt aggctaagag cagagtcaat 1621 aatatctgaa gatgtaacac caaaatgaaa aaacttgcca gttttagctg taaattgctc 1681 cgcaatagag gtacaaaatg cgatgatgtc atgctttgta actttctcaa tctcatcaac 1741 tctctcaggt ctaatttgtg ctctagcacg aatttccgca gctgtacctt taggtaccat 1801 tctatcttca agtgcctcta aaatcgcaag ctcaacctct aacatttttg catatttatt 1861 ctcatctgcc caaatttttg agatttctgc tatgtcatat ctttttatca ttttactacc 1921 ttatattcat aaaacacccg caagcacact taatgtatat aagctaaaac tgagctaaag 1981 cacaagcatg gcaatacatg atgaagtatt tgattcaact taaatatagt ttaattttct 2041 caaatagagt catattgtca atatatttat aaataatacg ctatcatggt tttactaggt 2101 tctgtgcaca aaaatagttt ctcagtagcc aaataaaagt acaagctaat ttaatcattc 2161 ctatatattc tgaaatggtt ttatcaaatc tagagaatac tcttctaaaa tgcttaattt 2221 tagaaaagaa attctctatc aaatgtcttt ctttatatac atgactatca aaaggtatat 2281 ggtttagagt atttgattta caagggataa cagcttcaga ggatatactt tgaatatgct 2341 gcctgatttc attagaatga tatgctctat cagcaataac ttttgtatta tatacatttt 2401 ttagtaaatt agctacttta ctatcatgag ttttaccttc tgacaacaat atttctattg 2461 gattacctaa agcatcagtc atagcatgga ttttagtggt tatcccacca actgatctac 2521 caattgcttg gttatcatct ttatcatatc ccgtagcaca agcatgtgct cttgctattg 2581 ttgaatcaag catgacttct tgtaaatcag ggttttgtac tgatttaaat aatctagaaa 2641 atatatcttt atcacaccaa tctttaaaac gcttatgtat tgatctatat ttaccataat 2701 aaaatggtaa catcctccat tgacagcctg tacgtaacac ataaaataca gcttcaataa 2761 ataatcttaa tttggcttca tcattggtat gtataccttt ttatgatttt aaaaatgata 2821 aaataattga ccagaatact tcttttatat gataattcat ttgctaaacc attgatattt 2881 attgcttttc aaatcttaaa taacagcagt ttagctattt tcaatataat ttaagttttt 2941 tgtgcacaga acctaattag ctgaggttat ttattataat gatatttgct tgataagttc 3001 taaacttaaa tcataataat ttaactaaaa acacatattt tattatagtt atgataaagt 3061 taatttagtc aactatgtaa gagaaaagga gataatatga aaaagcttat agtcacatct 3121 acatttataa ctgctttggt atctgtgagt tatgctaccg agctaaaagg tagcgactat 3181 atttcaactg aggttggctc aacatataac taccagcgcg taaatgctga tgatcaagat 3241 aaattcacaa tcgaaactac tattaaaagt tgtaataatg ctaaaacttc atgtgattat 3301 gtcagccaaa tcaaagatgt caacggtaaa actagtgcta attcaagcta ccaatatagc 3361 tatgttgtta gtgctgatgg cgctgtttat ataacctacc caaactcaca acaacaaact 3421 ctactattac cagctaaaat tgaatttaat aaaatcagaa acgataacgt tataaatgct 3481 gatactaatt cataaatact tatgagttta agaaacaaat tcccaaaata acagttaatg 3541 gtaatgaata taatgattgt attgagcttg agactaattc aacaattcag tctaatgaca 3601 agatacaaaa aacccattgc caagaagtat attgtaaagg tattggatta gttaaagaaa 3661 acctcaaaga aactaataac tcaagtaaac ctataactta taaaaatatc cttacttcaa 3721 ttacgaaata actttttatg agaaaaatat tcttttttta attccaataa tactattatc 3781 tagctgctca actagcaatt acactctaat caaaggtagt gaatatatat ctatgcaacc 3841 aaatactcaa tacctctaca aaagaacagc tcttaaagca gataaatcaa tttttattga 3901 tatagatata caatcttgta acagtgatca atcaaaatgc caatacttcg taagcgtaaa 3961 aagtgataaa gataaaatct tggagcaata ttacgaaacc tattatgtaa atttctttgg 4021 tgatgtatac ctaacagata gcttataccc caatggcaca ctaatattac cagctagaat 4081 tagactaggt gaggaattac ttttagataa tggtgataat tatggtctag tacaagagaa 4141 attacttgct tataaactta ttccagaaat acaggtaaat aatcacgagt ataaaaactg 4201 tgtaaatatc ttatttgaaa caacaactcc aactgaaact gtagatctaa agctagtgac 4261 tgatgagatt acttgtaaag gtataggctc tgttagaaaa gaaatgcaaa tgtcatataa 4321 acccaaattt gctaacacaa ataccgaaga tataaataac agtattatga aatttgctgc 4381 cacaaaaagt atcagcaaag atatggctcc ggaaggttct cttaagcctt ctgggcaaaa 4441 aaatgtagaa ctaaatactc aagattatat tcttatcgac acctacttag atattttgca 4501 agccattaca cacaaataag cgacctttta caaaaattaa tagccaaact ctatagtata 4561 tgaacgagag aaattttgct gtggttcaat gtcaacatta ccaatacgat actcaatatt 4621 aacatccata cctaatgtat cacttctacc acaccacggc tcaatacata catacggagc 4681 attagcctta ggttttgacc ataagccaag atattcaaag ccatcaaaag taacttcaat 4741 ataacgattt gaacctttct cagctaatct gactctttta tctgtgaaac cactatacac 4801 aagagcatca ttatcaaaag tatgattatc tagttcaatt ttagatagtt tgaaatgctt 4861 ggtttcacca gtataaaaag cctctggtgt aataggatga aaatctaatt tttgctctga 4921 aaatgtaatt tcataatcac tgaatttatg tttatcataa aaaggacaag caaatgctgg 4981 atgagctcca aagccacatg atgcaacacc gtcatctaga tttatgatat tgtattctgt 5041 gataagttta ttaacttcaa gagtgtatgt aacttcaaac cttaatctaa atggatagtc 5101 ttctttacta gtttccatag ctaagataac actattttca ctatgtaaaa caatatcaaa 5161 tacagtatga cgagcaagac catgatttcc cataggatat tctttaccct gatatttgat 5221 tttattatcg tgagatttac ccactacagg aaatagcacc ggagacactc cagcccacac 5281 acaaccatca ccagaccaca tatacccatg ttctgtagaa gtattaataa cagcgcgaac 5341 ttcggcacct agctcactga tttccactaa taaattatca tttttgatta taatcataac 5401 aataccctat cgctattagt gaagaggaga tttatgtcga aaaacactgt caccctcgtg 5461 cttgacacgg ggatctctca accatttaag agattcccat cttcatggga atgactgttg 5521 ttattaaatc gacagtcttt accgatacat actcaacaat tccctcttca gggttaactt 5581 caatatcttc agtacaaaat gagtagttga aaatctaaga tttaaaatac tctattagta 5641 ttttagcata ttgttggttt gtaaattaga ctatgactct attagatgat gaacttcacc 5701 aatttacaat ctattaattt tgctggatta tttgggtctc taactttttt atcttctaca 5761 ttaagcccgt caaccttcaa tttttcaaaa ctatttctgc tattatcagg tattttttga 5821 taattcgcca atggaatgat acaaattagc tcgaatttat tactcccctg agcgtgtaga 5881 taatcaaaaa cttttctagg attttcaatt tgccacattc ctctgattct taagttagta 5941 atacctaaag ggtcaacctt atttactcta ccaagctctt tagtctcaga aaaaacaaca 6001 tccggaacct ctttaatacc atccgatata gtattcctta ttctctcgta agtttcttgt 6061 tttgctgcat atatggagcc ataaaccatc cacagagact ttagttcgct atcatccgta 6121 tgaccaacac aatatatcaa ttttttaata tcccaatctt cacatgctct acactcattt 6181 gtaatcattt ggcttgagct tcttaagtca gctttgggat aactactatt aagagccagg 6241 ctactatttg cactctgtgt ttttttaact tcaatagcat cgcctccttt tatcataata 6301 tcaggagggt tattttgaga acctagtcat gaaaattttt cactataaat atttagctta 6361 tcttcttctg aatgctcaga gcctagagtt cctgcaaaag catcctttat atacttctct 6421 aatgcgtctc ctacactatt tgctctattt ctacctgtat acatttgctt tatgctatag 6481 tcacgatatt taactatatt tgcaattgct tctaaaatat ttgtcaaatc actttcctct 6541 cgttctgctt gcatatttgt aatttgatac attttgctaa aaattctgct aactttacag 6601 gcactgcatt accaatcatc ttatatcccg cagcaacttt atcataataa aaaacaaagt 6661 tatctggaaa ggtttgaatc cttgcacact ctcgaacact taatcttcta tacaaatgct 6721 ctttaccagg gacaaaaatc ctatgatttt gctccacaaa ctccatttta ggtgcttgtg 6781 ggtgtatagg tgcatgtcta cctccagcct gaattgtaaa agactgttca tcccagcttc 6841 ttactctatt cctagacata taaatagatg aaaaaccacc tcatgatttg ttactttaca 6901 cccgtctccg ttagtattat taagaggcaa agctggaatt acactctctc ttaaatccca 6961 aattgcatcc ttaagagtaa tctttggata tgtgttagtt gaaaaattaa agttaaatcc 7021 taaatcttta cggataccaa cgaagaaaac tctctgccta tcttgaggaa ctttaaagtc 7081 tgatgagttt aataatttaa aagaaagatt gtagccagca tcttcaaaca tttgctttat 7141 gttagttaat gcctcagtat gccttggtgc taacattcca cttacatttt cagctaaaaa 7201 acttaggttg tttagctttt agtattctta tgaaatcaaa aaaagttgac ctcttttatc 7261 ttttatacct cttaaagagc aggcttcact ccaactctga caaggtggtc ctcctattat 7321 accatcacaa tcaggaattc agattcatgt atatttacta tacttcttct atctaaaatt 7381 gtatttggat gatttttctc ataggtttcc catatctcct tatcaaattc atttgcccaa 7441 ataatatcaa atccagctct ctcaaaccct aagtcaagtc ctccagctcc tgaaaaaaaa 7501 gatactactt tcattatcca acccacttcc tagcatttct aaacattctc atccatacag 7561 aatactcatc atattccgct gggatatgcg agtttgtaat agctctatac acacgctctg 7621 gatgtggcat catcgcaagg acacgaccat ctaaagctgt cacagctgtt agaccattta 7681 ctgcaccatt tggattgtat ggatacatct cagttgcttg accttgccca tcaatatatt 7741 taagagctac ttgagcactt gctagcatag cttgttgctg gttgtcattt tcaaataatg 7801 ggcgaccctc accatgagct acagcaattg gtgcttttgt gcatgccata tcagcgaacc 7861 aaatagagtc agactcttga atctcaacca tagacactct agcctcaaac tgctctgatt 7921 tattcttgat aaatatcggc cagttttcag cgcctttgat tagtgattta agctgtgcaa 7981 gcatttggca accattacat acacctaatg ttaaagtatc atcgcgccca aagaatctac 8041 taaactcatc tcttagcttc tcagtaaaga ggatattctt cgcccagcca ccgccagcgc 8101 ccaagacatc accatatgag aaaccaccac aagctaccaa tactttgaaa tctgccaaag 8161 ttacacgccc agcatgtaaa tctgacatat ggacatcatg agcctcaaag ccagctgtag 8221 taaatgctgc tgccatctca acttgaccat tgacaccttg ctctcttaag attgtaactt 8281 ttggcttttc aacattgaca aacttagctg tgatatcctc ttcaagatca aatgtagcct 8341 caacatggat acctttatca ttagtattta agatactatc gaactcttgt ttagcgcatt 8401 cgctattatc acgaattgat tggatttgat aagaagtctc agcccaccat ctttgtaaat 8461 ttacacgtgt gtttgagtat attttttcac catttgcaaa gatatttagc tcatcactag 8521 agtttagctt agctattgca cacaggtgaa tttgagtatc tttaaacatc tcttcaacta 8581 gtgatacatc gctatttcga acttggataa caactccaac ttcctcggca aagagtttcg 8641 ctaacacatc ttgagtttgt agtttaacat ctaaaccttt acgccctgca aatgacattt 8701 ctgctaaagt tgcaaacaca ccaccatcag atacatcatg atatgctaaa attttatttt 8761 cagcttttag tttagtgata ttttcaaata gcacttttac cttacttgct tcaatatctg 8821 gcgcaacatt accaacttga ttataagctt gagctaaaca tgaagcccca agtctaccgg 8881 caccatttga tagatcaatg tgtaataaag ttgtatcatt atcatcaact aaaactggtg 8941 taagagtctt acgcgcattt gtcacaggcg agaaacctga gatcactaac gataatggcg 9001 atgtcactga tttagcttga ccgttatctg accacttagt tttcattgac attgaatctt 9061 taccaactgg tattgcaata cccaacgctg gtgcaaattc cataccaaca gctcttacag 9121 tttcatataa tttttggttt tcgtcacctt gatttgcagc aaccatccag ttagcagaga 9181 ggcgaatgtc actcaacttt tcaatatccg cagctaataa gtttgttaca gtctcagcaa 9241 tcgctaatct accagaagcc gcagcattaa tagcagcaac aggagttctc tcgcccattg 9301 ccatagcctc accagcttga ctatctacag tagcagttgt cacagcacaa tcagctacag 9361 gcacttgcca tggaccaacc atttgatctc gtgcaaccat acctgtaata cttctatcac 9421 caattgtgat taggaaagat ttagaagcta cagctggtac ttttagcact ttctcaatcg 9481 cttcatcaag cttaatagca cttgtatcaa aagcttgttg ctcaactttg acagttttta 9541 catcaatatg catttgtggt gtattaccaa ataataatcc cattggtaaa tcaaccggct 9601 tattatcaaa atactcatca tttagagtga tatgcttttc agaaatcgcc tcaccaacta 9661 ctgcaaatgg acatctttct ctattacata actgctcaaa aagctctagt gactcagggt 9721 caactgataa tacatatctt tcttgtgact catttgacca tatttccagt ggagaaagcc 9781 cctcttcacc gacatttact tttctaagct caaaataacc gcctacgcca ccatctttga 9841 caagctctgg gaaagcattt gaaataccgc cagcaccaac atcatggata aatgtgattg 9901 ggttattctc gcccatttgc caacatctgt cgattacctc ttggcaacgg cgctccattt 9961 cggcattatc acgctgaact gatgcaaaat ccagctctga gttagtatca gaagatacaa 10021 cagatgacgc agcaccacca ccaagaccaa tacgcatcgc aggcccacca agacagatta 10081 gcttagcacc aactttgata tcgcctttct caacatgcat tcttttgata ttacccatac 10141 caccagcaat cataattggc ttatggtatc caaacatctc tttgccagca gatgtattga 10201 cctcttgctc ataggtacgg aaataaccat ttaaatttgg acgaccaaat tcatttgagt 10261 aatgagcacc accaataggc gcctctagca ttatttgtaa aggtgttaca atatggttag 10321 gcttaccata tttactagtc tcccaagcct gttcaaaacc tggaatattt agatttgaaa 10381 ctgtaaaacc agtcaagcca gcttttggtt ttgctccaag acctgttgca ccttcatcac 10441 gaatctcacc accaacacca gtagctgagc cactaaatgg tgctatagca gttgggtgat 10501 tatgagtctc aactttcatc aagatatcaa cttcttcttg attgaaacta tagacaccat 10561 tttgcgtatt tggatagaat ctttgagccg ttgcaccctc tatcacagca gcattatcct 10621 tatatgctga tagcacacct tgtggagatt tctcagtagt atttctaatc atcttaaaca 10681 atgatttatc ttgctcctga ccatctatag tccatttagc attaaaaatc ttatgtctac 10741 aatgctccga atttgcttgg gcaaacatat ataactctgt atctgtagga tttctaccaa 10801 gctttgtata ttcatctgct agatattcaa tctcttgctc acttagagct aagccaagtt 10861 ttctatcagc ttctttgata gcttgagcac ctttttctaa aacattaaca aattcaagtt 10921 cttttggtgc tgttacacta aagagtctat ataaatcatc tttgcaacta aacacttcct 10981 caaccatacg gtcatgaacg atatcttgga tttgttttag ctcactagca gaaacttgtc 11041 cctcaacacc gaataaaata gctctttcta tccttttaac agctttgata ccagtatttt 11101 tgataatatc ggtagcttta gaagaccaag gcgatatagt gccaactatt ggagctatga 11161 taaaagtatg acccataggt tgagctatgc catactctct attgtagtta agtagagatt 11221 taactattct ttcttgctca ctatttaact ctgattcaag ctctgtaaca tggatatact 11281 gtgcagatac tgattcaact ttattggata tttttttagc agctgctaaa attttttctc 11341 gcttaaaagg agacagtgca cttaaacctt caaaaatcgt aatcattagt tatcaaaccc 11401 tttgtatttt ttttctaatt cttttaactc tttacgatgt ttctctagca catctagata 11461 agcatcatcg acatcacctg taatgtaatt accagagaaa acactatcct caaactctct 11521 aattttaggg ttttgctttt gaataatctc ttttagatcc tctaatggta aatatattag 11581 tccatctact ccaatccact ggcgaatctc ttctatagtc tttccatgag caattaaatc 11641 cgacttaacc ggcatatcaa taccataaac atttggataa cgaacggctg gagatactga 11701 agcaagataa acagatttag cacctaaatc tctaatcatc tcaataatac gctttgatgt 11761 tgtacctcgg acaatagaat catcaacaag tagaacattt ttatccctaa attctgctgg 11821 aatagggttt agttttcttc tgacaaaatt ctttctatca acattctctg gcatgataaa 11881 agttctacca acatagcgat tcttaacaaa accttcacgg tactcaacac ctaatgctgt 11941 tgcaatctct tgagcagagg ctctacctgt ctcaggtata gggataacga tatcgatatc 12001 cttatccttc cacgcttctt tgattctctt acttaggatt ttacccgcat ctactcgcgc 12061 ttgataaaca ctcacaccat tcataatact atcaggacgt gcaaagtata catactcaaa 12121 taggcatggt gccaaaactg gattctttgc acagatttta gagtgaactt ttctatcctc 12181 tgtaattatt atcacctcac caggctcaac atcacgtaat actttaaatc cggaaatatc 12241 taaagcaaca ctttcactag cgaccatgta agctttttca ccatcatcgt actctttaaa 12301 accaagcaca agtggacgaa taccataagg atctctaaaa gcaattaaac caaaatttgc 12361 tatcatcgca gtacatgcat aaccaccttt gacatgctca aaaacaaatt tacatgcttt 12421 ataaacagcc tcagaagtcg cagatccttt tgatttattc atcccacaag caaagaaatt 12481 aagcaataat tcggaatctg aacttgtatt aagatggcgt ctttcaatat catggagcat 12541 ttgtgcaagc tctggcacat tagtcagatt gccattatga acaaaaacta taccatgggg 12601 attatttaca taaaaaggtt ggctatcagc agcacccaag ctacctgcag taggatatct 12661 aacatgaccg atacccatat taccttttga cttctctagt ttttcatctg taaatacatc 12721 acttactaga cctgtatttt tacggataaa aaagtgccca tgatccatag ttgcaatccc 12781 tgcagcatct tgacccctat gctgcaaaag acttaaacca taaaataatg cataactaac 12841 ctgatctggt ccagcgactc caattactcc acacataaac ttccgactac tcttagtata 12901 aattaattat taacaaacaa tattataaca atatttaacg cgataactta atcaaaatca 12961 cctaaaacac taatgtgcaa aactactcct ttttaatatt tttaactttc cctctaatga 13021 atcaatcacc acaactaaat ctctaatcat caactgtgcc aagtcataac taaagcctct 13081 tctaactaat acacgcataa ccactaaatc ttcacgattg tttggcattg tgtaagctgc 13141 tatttgccaa cctttagcgc gaactctcag atatatcaaa caaactatac tctttagttg 13201 ctttaagtga ccagctaacc gcaggaatac caccctctcc agcatgaata atttcaaaaa 13261 tttccatttt tctaagctct ttagcaatat attctgcaat atcatagcaa agctgatgaa 13321 ctttcttata gccttcaaaa cccaacctaa caaaattata atactgggct actatctgac 13381 caccaggtcg cgagaaattc agtgcaaatg ttggcatatt accacctagg taattaacat 13441 taaaaatcaa atcatctggt aagtactttt tatcagccca aataacccaa ccaaccccaa 13501 gtggcgatat tggtaatcta aagtcccact taagttcagg ctctacaaat ggtgccaaaa 13561 aacctccaga tgctgcatca acatgaactg gaatatctac gcctgtttgt cgttcaaaat 13621 catcaagagc tttacatacc tgttctactg gctcatactg ccctgtaaaa gtcactccaa 13681 gagttggcac cacaccgatt gtattttcat cacatctttc aagcacagcc tctggagtca 13741 ttattaaact ttcattcgac attggaattt ctctaagctc aatatcccaa tatctagcaa 13801 atttatgcca gcacacttgc acaggtcctg taacaagatt aggttttgta taatctttac 13861 cttgcgcttt cattttatct cgccaacgcc acttcattgc cataccgcca agcatagcag 13921 cctctgatga gccagtcgtt gagcagccaa ttgcattttc tgctgaagag ttccataggt 13981 ttgcaaggat atttacacag cgagactcta tttccgcagt ctgcggatat tcatctttgt 14041 caaatatttt tatcaatgca atcatccata agcttgtgaa tgaaatcatc aacttccgtt 14101 tggcaaaacg tctctaaatt ttgcttcgaa ttaccatcta gcattaactc atctttgatt 14161 tcttgataca cttctaaagg atcttgtgaa tttagtggaa gtttaaactt tggtaaagat 14221 tgttcaaaaa aatcaaggtt atcaattgta tcttttttac catgtaatgc cataatcctc 14281 tctctaaagc tgtatctgtt taaatttaaa atctactatc tcgaatagat taattttctg 14341 agcgacaata tttttacaac atatcgaaac tattgattca tcatatgaaa atgtcacaaa 14401 atcatctgga taactattac taagccatga gtcattgatt ttactaaaat tagcaccact 14461 caagccttta gctatcccaa gcgagtctct ttttacctga gcttccttga gtgtccataa 14521 cgtataaaag tctttgacgg gattatcact agcagcaagc cattgatttt ctaagctagt 14581 aaaataacgt tgtgcgattc ttataatatt ccgtctagct gatagttttt caatatccac 14641 accaatctct tgatcagcaa cagcaattat aagctttgtc tgtgtatgac taatattgaa 14701 aaaaacactg ttatctgcca agtacggttt accatgttga tttaaaaaaa ttggtgaaga 14761 aatatgataa aactcttcta agacaaaata gcgaacaaac tgtgaaaata ttttttgctt 14821 attattaaac cttgctgaat caatatttct gcaacaaaga tatcctctaa ggtcctcagc 14881 tttatatttc tcaaaatcta aaataaaagc tgagacttgt ggcatcaaac taattactcc 14941 gttgcaatct gcgatattat atctgtagtt cctaaaatag tattgatgta ctcaatgtct 15001 ttgtaggtta aactcccctg taattgcttt aaacttacat aatcttcaac atagttgaat 15061 atagcatctg caaatgataa ttgtgcttgg acaaggattg cctgacggtt aagtaagtca 15121 acaattgtct gtgtacctgc ttcaaaacct tctaatatcg cttttacaga agctatacct 15181 gaatacacag actttctaaa cgcctcaatt ctaactgcat caagaacaac tgtttgatat 15241 gcctctactg taccagcgta gacttctctc ttggtttgta gcaaggcata gttcgccgct 15301 tgattatcat aactagcttg cttgagttgc gcatagtcag aaccacctct taataaattc 15361 cagctaactt gaccaccgat attagcaacg tcatatttgg ttggaatttc ggctatttgt 15421 gctggtgaac ccgaaagagc gttacgtgac atcattatac cgccagttaa attagcttga 15481 ggaaaaaatt taccccattg aataccaaca ccttcttgtg ctgcttcata ttcaaacttt 15541 ttctgcgcta tatcaagatt atatttctca gctgtattca accaatagtt aatatcatct 15601 ggaacaggat taccaaattc agtatctttt gatatatata aaattgagct tatacgctta 15661 ccgataagtt tagccatcac agctttggca ttaatgaagt ttctttgtgc attaacccta 15721 tcagcgattg cttgacgata ttgtgcatct gtagttttaa aatcagcata tgaaaccatg 15781 cccgaattat actgatattt ctgagtcaga tataactttt tgttccaagc ctcatttgca 15841 aattggaact gtaacgcctg ttctgctctt agcagctcaa aatatgcagt aatagtatca 15901 gttataagtg tttgttcagc tttagcataa atcatcgcat acgatttttg caaataggtt 15961 gcttgagtat atgtcttcca tttactccaa tcaaaaagaa cctgagaacc actaaaattt 16021 actacatttg aagtgtcatt gactctacca ccaaactgat tgtacaaatc tcttcttaga 16081 ttatagttaa aatcaatctg tggtaataat gcacctaaag cagtcggcac agtttcaaca 16141 tttgccgcaa aagtagacct tgctgcttgg tagtcggcat tatgttcagc agataactta 16201 tagatatcaa ttaaactata atacttgtcc tcagtatcgc caaccatcgc gacttcatca 16261 gcttttttaa gattatagaa tttattgtct accttaattt gatctgcttt ggcatattgt 16321 ttttcgacac tatatggatt ttcagcaaca tcagtaccaa taggtcttcc tgcatactta 16381 tattcaggaa caggcgtatc ttcattagct aaagctagac aaaaccccaa aaaacctaaa 16441 agatataatg ttaacttctt catagcactc tttacttatt gtatgtatta aagagaaaac 16501 tcttttcgta tgtttgcttt ggagtttttg ttattaagta tgctttatca catatagctg 16561 ttctaacgac aaatatcagt ctaccgccag tctcaagaag ccctaataac gactcatcaa 16621 tctcatcctc agtaacaact tctgatatgt agatacaatt atattttttg ccatttttta 16681 taatattagt tatatgctca gcactattaa actcaacatt atatatacca atacttgcta 16741 gctgacgcct tgctacggct aaccctaact catcataatc aacaagctca acacttttac 16801 ataacttggc tattaaagct accggataac cactttccaa accaagtttt aagacattat 16861 cactaacttt gatggctaat gcttctataa gcctagctgt aaacatcgga cttcttaatt 16921 ctctttcatt tacaactaaa tttgtgtcgc aataagctaa agtttgaagc tctctaggca 16981 aaaaaatctc tctaggaata tctgccataa ctttagcaac accatctaaa gaaagtcctt 17041 cagtaagaac ctgttgcttt accatatttt ctctagcaag ctcaaaattc atattagatc 17101 ctattaaata attaagaagt aaatttcatc tactatttag acaaaagata atagcataat 17161 accacagcaa aagaaacctt actacttttt gccttaagtt atttatttta tagaaatatt 17221 ctaacaagaa ataaataaaa gtatatgcaa ttgtattagc acgatactta atattatctg 17281 ccctttatca tttatgctct tatcaaaaaa taaaccttta tagataaaca ataaaaagtt 17341 aaaattattt aatataaatc attcgcttta tacaaacaat aaatacttag tcaaggaata 17401 taaagataca aatgaaaaga cctgaattac tatcgcctgc aggaacttta aaggcgatgc 17461 gttatgcttt tgcatacgga gcagatgctg tatatatcgg ccagccaaga tatagtctaa 17521 gagcacgaaa taatgagttt tcaaagctag aaatacttga gacagctatt actgaagctc 17581 atgctcaagg caaaaaaata atgctggcaa acaatatcgc cccacataat gcgaaaatca 17641 aaacttacat aaaagatata accccagtaa ttgctcttaa acctgatgca atgattatgt 17701 ctgatccagg gatgataatg cttgttagag agcatttccc tgaccaaaaa atacatctat 17761 cagtacaagc aaatgctgta aattatgaga ctgttagatt ctggcaaaaa tttgggatta 17821 tgcgtgttgt tttatctagg gaattatcac taaaagaaat cgccgaaatc aaagagaatg 17881 ttccggatat ggaaattgag acttttgtac atggttctct ttgtatggct tactcgggta 17941 gatgtttact ttctggatat tatagtcata gagatcctaa tcaaggtgtc tgtaataatg 18001 cctgtcgcaa taattacaaa gtcgctgaag caaagcagaa tgaatggggt gattttgagc 18061 caatccagac acaatctact ttagggatag gtacaccatc tgacaaagtt gtcttaatag 18121 agaatgataa agagcctggt caatataacc caatgtttga ggatgagcat ggcacttata 18181 ttatgaactc aaaggaccta cgtgcaatac aacatgtaga aaccatgatg aaaatgggag 18241 ttgactgttt taaaattgaa ggaagaacta aatcattctt ttatgctgca agaacagccc 18301 aactttatga ccaagcaatc aaggatgctc tagctggtaa accttttgat atgacactga 18361 tggataagct tgaaggtctt gcacacagag gttatacaga gggtttctat cgtcgtcatg 18421 tccacgatga atatcaaaaa tatgataatt ctgattcacg tagctccaca caacaatttg 18481 ttggagaaat cactaacttt gatgcgcata ctggatatgc tgatgtcaat gtacgcaaca 18541 aaattaagat tggcgatagt atcgagctaa tgttaccatc aggtagccga gaaattatct 18601 tagataatat gcaagataaa gatggcaagc atatggaaga agcaaaaggt agtggctatc 18661 aagctaagat aaagtttgat aatgttacag ctgaagatat gaagttcgct ttaatgatta 18721 aaaataaatc accaaacatc tag //