LOCUS NC_009699:12 18550 bp DNA linear BCT 03-SEP-2013 DEFINITION Clostridium botulinum F str. Langeland chromosome, complete genome. ACCESSION NC_009699 SOURCE Clostridium botulinum F str. Langeland chromosome, complete genome. COMMENT locus start: 2116500; locus end: 2135049 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.547674; n0_4mer:D = 18.344682; n0_4mer:PS = 32.546595 FEATURES Location/Qualifiers source 1..18550 /organism="Clostridium botulinum F str. Langeland chromosome, complete genome." gene 337..780 /gene="" /locus_tag="" /db_xref="2116836..2117279" CDS 337..780 /gene="" /product="MarR family transcriptional regulator" /translation="MNNTQLNEISQDLYDLLLNLQKKLFNPDELKKKFSLPPSHIKAI VYLKHNGNCSISKIAKDLLISKPNMTPIIDKLISENMVTRYTDPKDRRVIRVELTEEG VLFIKDQEKLIKALLAEKISDLPSQDLQYLSDHIIEIKNIILKIN" gene 893..1333 /gene="bltD" /locus_tag="bltD" /db_xref="2117392..2117832" CDS 893..1333 /gene="bltD" /product="spermine/spermidine acetyltransferase" /translation="MNLHLEEVTIKNWRSIAALKANENQQNFIESNAYSLAEWKFVPD FHPKAIYDNNKLIGFAMYGYFKKETRLWLDRFMIDYKYQNKGYGKSSLELLISVMINE YKCNKIYLSTFKDNIGAIKLYEKFGFEFNGEFDENGELIMVLKV" gene complement(1562..2245) /gene="moeB" /locus_tag="moeB" /db_xref="2118061..2118744" CDS complement(1562..2245) /gene="moeB" /product="molybdopterin biosynthesis protein MoeB" /translation="MSRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIG IGYITVVDGDNFSESNLNRQIISSNLNLRKNKAIEAKKRMKIVNDLIYVNPVTTFINK DNVLDILKEHDVVIDAVDNIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRT LDIIYKNKSKKGIEDVLGNPSFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQ DFYILNLKE" gene complement(2247..2474) /gene="moaD" /locus_tag="moaD" /db_xref="2118746..2118973" CDS complement(2247..2474) /gene="moaD" /product="molybdopterin converting factor subunit 1" /translation="LKIEVRLFAYFREGRDKKYFMEINNENITPRHILEELNIKVEEV AILLINGRDGKVDTLLKDGDVLSLFPPVGGG" gene complement(2757..4574) /gene="aor" /locus_tag="aor" /db_xref="2119256..2121073" CDS complement(2757..4574) /gene="aor" /product="aldehyde ferredoxin oxidoreductase, tungsten-containing" /translation="MYGYNGKILRIDLTNRNCTLEPLDEEKAKKFIGARGLGVKTLLE EIDPKIDPLSIENKLVIVTGPITGAPMPTSGRYMVVTKAPLTGTIAISNSGGKWGTEL KNAGYDMIIVQGKSEVPVYVNIEDDKIEIKEADHLWGKTSLETTKILCNENNERAKVL CIGPAGEKLSLMAAIMNDIDRAAGRGGVGAVMGSKNLKAIVVKGSGKVKVFNEGEAKK VSLEKIKILREDPVAGGGLPTYGSAVLVNIINENGVHPVRNFQKSYTDEADKISGETL TEDCLVRKNPCYRCPIACGRWVKLDDGTECGGPEYETLWSFGSDCDVYDLNAINVANM LCNEYGLDTISAGATIAAAMELYEKGYIKDEDIKGDGLSLKWGDAEAVVGWTKKMALR EGFGDKMADGSYRLCESYGVPEFSMTVKKQELPAYDPRGIQGHGITYAVNNRGGCHIK GYMISPEILGYPEKLDRFSLEGKAAYAKIFHDLTAVIDSLGLCIFTTFGLGVQDYVDM YNVVVGGKLHDAESIMEAGDRIWTLEKLFNLEAGIDSSHDTLPKRLLKEPIPEGPSKG CVHRLSELLPEYYAVRGWDKNGIPTEDTLKKLGLEEYIK" gene complement(4668..4799) /gene="" /locus_tag="" /db_xref="2121167..2121298" CDS complement(4668..4799) /gene="" /product="hypothetical protein" /translation="LTLDKVKFLSRYIEAFKYTKYGFYRVCTNIITNNYRYGILVYT" gene complement(4968..6863) /gene="aorR" /locus_tag="aorR" /db_xref="2121467..2123362" CDS complement(4968..6863) /gene="aorR" /product="aor transcriptional regulator" /translation="MKDNFINEKFCILKSHEKCNSLGISKDLVYSKKIIKDEELKREL NNNSELIIIATPFMNKLYQFVKGSNFFVILTDGDGCILNVIGDESILKEASNVKMIPG AYMDEKNMGTNAMSMALSEKSPIQISGEDHYVKAYHRWTCSAAPIKDINGKIIGILDL TGYSENVHSHTLGMVAAATNAIEKMIELNDYNRALQISKKSIENVFNSIQRAILRVDL SGAIKTINNNAIELLGFNENDIKSMKMWDLIPDWSMVLDEIYDKGSFVDEDVYVHCLK NKLQLNLSAYPIYDSSMRIIEVTCLLSDIQKTRKLAGKILSGQAIYTFDKIIGKSKKL LSIIDYSKKIADSRSTILITGDSGTGKEVFAQSIHNYSDRKDKPFIAVNCGAIPRNLI ESELFGYEEGAFTGAKRGGYRGKFENSHGGTIFLDEIGEMPLDMQIKLLRVIEEGVIN RIGSSKQIPVNSRIIAATNKDLGEEVEKGNFRKDLFYRINVLPVYLPALKERREDIPL LIDYFMNKTSKHLNKRKVEIPSVYMERLMNYHWPGNIRELENIVELIINAESVEIINN INHYSSKEVRDKAKEETMVFNLEIVEKNHIKEVLNKFDGNVSSAAKALGIGRNTLYRK IEKYSLY" gene complement(6913..7353) /gene="" /locus_tag="" /db_xref="2123412..2123852" CDS complement(6913..7353) /gene="" /product="MOSC domain-containing protein" /translation="MAKVIAVNISEKKGEIKHPIDKGLFKVDHGLVGDAHAGNWHRQV SLLGTESIDKMKKLGLQGLCTGKFAENITTEGLILYELPIGTKLKIGEVLMEVTQIGK ECHAGCEIRNLIGDCIMPREGIFTKILKEGFIKPEDEIEVLSDF" gene complement(7355..7834) /gene="moaC" /locus_tag="moaC" /db_xref="2123854..2124333" CDS complement(7355..7834) /gene="moaC" /product="molybdenum cofactor biosynthesis protein MoaC" /translation="MELTHINKQGRAKMVDVGSKGDTEREAIAYGYINMKKETLNKIK EGTISKGDVLSVAQVAGIMAAKNTANIIPMCHPIMINGCDINFNLDFENNNIDITSSV KNTGKTGVEMEALTAVTVAALTIYDMCKAIDREMTISDVKLMKKSGGKSGLFQREEL" gene complement(7838..8797) /gene="moaA" /locus_tag="moaA" /db_xref="2124337..2125296" CDS complement(7838..8797) /gene="moaA" /product="molybdenum cofactor biosynthesis protein A" /translation="MLDKHGRKINYLRVSVTDRCNLRCVYCMPPEGIVKKEHDNIMRY EEIFKVVKSASLLGVNKIRFTGGEPLILKDIDKLIYNTSKINSIKDIAMTTNAILLED MVEELKKAGLKRVNISLDSLKEDRFKSITRGGDINKVFKSIEKSLSIGMKPIKINTVI MKGINDDEIDDFMNLTKKYPISVRFIELMPIGEGRKLYKDGYISSEEIISKHSDLIPV ETDKSSTALLYKFKESKENIGFISPMSCKFCSGCNRVRLTSEGTLKPCLHSEKEVDLK NYVDSSQALLSKINETIYNKPLEHHMIEEKESKSKKMMYQIGG" gene complement(8856..10760) /gene="" /locus_tag="" /db_xref="2125355..2127259" CDS complement(8856..10760) /gene="" /product="molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein" /translation="MGQNIYLSNYEIEEALKFYFSKISIERQNEFIDTEYSSNRITAS PIYSKISSPFYNSSAMDGIAVNSEKTLGANEKNHIALEEEKDYIVVDTGDPIPREYNA VIMVEDLIKVDDKRVKIYKSIAPYENIRPLGEDIVEKSLIVPSYHKIRPVDISAMIAG GVNEVEVYKKPLVGIIPTGTELVEPGSNLKVGDIIDFNSRTFAAQVFEYGGIAKRYEI VKDNYEKIKDTIKKAVKECDIVLVNAGSSAGREDYTAKVIEDLGRVYIHGVAIKPGKP VILGKIDNKPVIGIPGYPVSAYVIMENFVRPMVEKFAGEKPYKYKKIKATLSKRVMSS LKYVEFVRIKLGKVGEKVVATPLNRGAGATMSLVRADGILEVPQNVEGIEKGTEVDIK LLKDEEEINNTIVCIGSHDPIIDVIADLIHVKQGEYYLSSAHVGSMGGIMALKNGETH IAPIHLLDMESGEYNVSYIKKYIGNRPMALIKCVKRIQGIMVPKGNPNNITSIRDIRD KKLKFVNRQRGAGTRLLFDYNLKKLNINPREIKGYEREEYTHLQVAAAISNGDAHCGL GIYSAANMMGLDFIPVCNEEYDIVIFEEFLSMPSIKEFISIIKSDKFKEKLDELGGYD YSEAGNIVFI" gene complement(10772..11998) /gene="moeA" /locus_tag="moeA" /db_xref="2127271..2128497" CDS complement(10772..11998) /gene="moeA" /product="molybdopterin biosynthesis enzyme MoeA" /translation="VDLFNVVSIKEAKSLIEKNFNVKPIKEEVELLSSMDRVIYEDIV SHINVPNFRRSTVDGYAVNSKDVAGASESMPAMMNYRGEVFMGKIPEVNMDFPGDCVY VPTGGMIPEGSDSVVMVEYTERVHEDTILINKATAYGEKVVEIGEDIAKEEIMIKKGK RLRPYEIGVLSSLGITKVPVCRKPKVAIISTGDEIVDPNKEPNLGEVRDINSYLLQAS IIEDGGIPINYGIIRDDFNLLKNTVEKAIEDTDIVLISGGSSVGKKDVTIDVINSLGD PGVFVHGIAIKPGKPTIIGNVKDKIVFGLPGHPLSAAIVYKVIVKYYIDKIAGVKEKV FPIVCKFNINYHSAKGREEYLPVTLNWKENEIIASPIFSKSGLISGFSKAYGFMKIDK NLEGIKKDEKVFVYRF" gene complement(12022..12510) /gene="mog" /locus_tag="mog" /db_xref="2128521..2129009" CDS complement(12022..12510) /gene="mog" /product="molybdopterin biosynthesis enzyme Mog" /translation="MIKTAIVTISDKGSKGERKDETGKVLQDILEKEGYKVEDYKIIP DEINIISGELIKLCDEKKVNLIITNGGTGFSKRDVTPEATEKVIEKHVPGFGEAMRTS SLSITPKAILSRGIAGIRKDSLIINLPGSPKAAAENLQAVLGAIPHGIEILLGEASEC AR" gene complement(12712..13404) /gene="tupC" /locus_tag="tupC" /db_xref="2129211..2129903" CDS complement(12712..13404) /gene="tupC" /product="tungstate ABC transporter ATP-binding protein" /translation="LKIEVVNAVKEYVGRKVLDIEHMVFKEGSIYGILGLNGSGKSTL LQSIAGFNKLNEGEIIYDGKDFNKVKDKISMMAQRPLLFNCSAGENIIMGLKFRKTPR KTVDARFEKYIKYFNINEILNKNGKKLSGGEAQKVALLRTVILENDVIILDEPTASMD IESTLASETLIKDIMKDKRTVIFVTHDFYQAERIADYVIFMDKGKIIEQGETDNIFNN PKNAKVKMMLNK" gene complement(13401..14072) /gene="tupB" /locus_tag="tupB" /db_xref="2129900..2130571" CDS complement(13401..14072) /gene="tupB" /product="tungstate ABC transporter permease" /translation="MEQEIFNIINLKEIIPVVLMSLYVSLTSTLIASILGMLLGIPCA LLNFKLKKIIIQINHTLMSIPPVLMGLLVYLLLSRKGPLGEFELLFTPTAMIIAQTSL IFPIVFGLSISIIVKSGKDIKNTCTTLGANRFQTFLIIIKENKIQLLSVVTAAFGRAI SEVGAVMIVGGNIKGFTRVMTTYIALETGKGNFNEALAIGGILLVISFIINAILHFFQ GSESF" gene complement(14081..14932) /gene="" /locus_tag="" /db_xref="2130580..2131431" CDS complement(14081..14932) /gene="" /product="tungstate ABC transporter tungstate-binding protein" /translation="MKKILLLLSGIFLTLSLVACDKSNSTESTKEEDKSRTMILATTT STQDSGLLDYLLPEFKKDTGIDVKVVAKGTGEALKLGQNGDADCLLVHAKAKEEEFIK KGYGTERHDVMYNDFIIVGPKEDTAKLKEKAPNNAAEAFKLIDENKASFVSRGDESGT HTKEKKLWKDIKVDPKGEWYISAGKGMGAVLQMANEKKAYTLTDRATYLSMKDKLDLV IVTEKSNDLYNQYGVIMLNTEKNKIKEKEAKEYIDWMLSDKGQKLIGEYGKEKYGQAL FVANGKK" gene complement(15152..16474) /gene="" /locus_tag="" /db_xref="2131651..2132973" CDS complement(15152..16474) /gene="" /product="MATE efflux family protein" /translation="MSSTTKDLTKGSPLKVILKFSLPMIVGNIFQQLYNVVDSIIVGK FIGTKALAAVGSSFAIMVFITSILLGLCMGTSIVFSQFFGGKKINKLKASISTSFIFI GITSIIISALSLIFVDQIILFMKIPKELFVDTRSYLKIIFSGIFFTFLYNWAAGLLRA LGNSKVPLYFLILAAIINIVLDLVFVITFNMGVSGAALATVIAQFVSAILCIVYCIKK LDFLEFKLSEIKFDKEIFKLTASYSMLTSIQQSIMNFGILMIQGLVNSFGIAPMAAFA AAVKIDSFAYMPVQDFGNAFSTYIAQNKGAEKDERIKSGIKVSLKIITIFCIFISLVV WIMADKFMLIFINPTETQVIKIGIQYLRIVCTFYCFIGYLFMFYGLYRGLGKVKMSIV LTIISLGLRVALAFITAPYLGLKGIWWAIPIGWIIADIVGMIYYRSIS" gene complement(16474..16671) /gene="" /locus_tag="" /db_xref="2132973..2133170" CDS complement(16474..16671) /gene="" /product="hypothetical protein" /translation="MIILETENSILKSISLGDAQKVYFLTSHVEVKEFMRFNTHYCKD KLLLPDLTLGNFDLYIRFGEE" gene complement(16913..17557) /gene="" /locus_tag="" /db_xref="2133412..2134056" CDS complement(16913..17557) /gene="" /product="hypothetical protein" /translation="MKINKKYLVFTLCIVWIISIYIFNKYDFISLTIEIMKGYLDSNK VGIMAIFVLLWIVRLPILLPGFTLIILGGTLFGTTNGFLLSMVGMVLSETLVYVIARV FSNWNIKNLIKKKYDYVEPLIKKYNFRFLALGIACPIAPTDVICFLSSSLGLSYIKYI LTIIISNIPIIAIYSYMGISYKESSLSIIILCLSISVLALYTMKIWNGLKTNYL" gene complement(17879..18550) /gene="" /locus_tag="" /db_xref="2134378..2135049" CDS complement(17879..18550) /gene="" /product="ABC transporter ATP-binding protein" /translation="MNTVLEFKNVNYSYKDAGKELIILESVDFNFESGKFYTILGASG SGKTTALSLASALDSPKSGEILYEGKDIKKIGLTNYRNQYIGIVFQAYNLINYMTGIQ NIVTAMEITRNEIPDRKQKAYELIEKVGLKREEGERSVLNLSGGQQQRVAIARALSTN AKIILADEPTGNLDSKTSVDIIKLFQKLAHEDNKCIIMVTHSLEIASMSDVIINLDNK KFKVK" ORIGIN 1 aagataaata attccccctt aaaaaattaa atttataatg attgtatttc ctgtttttaa 61 caatacaatc attataaatt cataactatt atattttaat atattttatg tgtcaataac 121 ttttgtattg taaaattatg aaaaatacaa tataatttaa ttaaaaaatt ttaaaatata 181 cactaccttc cctttaccta tgtcaatata atagttatac tttcataact attatatttt 241 aatatatatt atatgtcaat aactttttgt attgtataat acgtttaaat acaatataat 301 gtaattaaaa cataaaatta actaaggagg ataaagatga ataataccca gcttaatgaa 361 atatctcaag atctatatga tttattatta aatttgcaaa aaaaactttt taatccagat 421 gagctaaaga aaaaattttc cttacctccc tcccatataa aagctattgt ttatcttaaa 481 cataatggca actgttctat ttctaaaatt gctaaggatt tattaatttc taaacctaat 541 atgactccta tcattgataa actaatttct gaaaatatgg ttactagata tactgatcca 601 aaggatagaa gagttataag agttgaatta acagaagaag gtgttctctt tataaaagat 661 caagaaaaat taataaaggc tttgctagca gaaaaaatat ctgatcttcc gtcccaagat 721 ttacaatatc ttagtgacca tataatagaa ataaaaaata ttattttgaa aataaattaa 781 ttttttgtaa atataacata gtataaaata attttaatac ttgaaaatcc attattaaca 841 ataacttttt tatagtatta catataaaat taaataaagg taggttaaaa taatgaactt 901 acatttagaa gaagtaacta ttaaaaattg gcgttctata gctgctctaa aagcaaatga 961 aaatcaacaa aattttattg aaagtaacgc ctattctcta gcagaatgga aatttgtacc 1021 tgactttcac cctaaagcta tatatgacaa taataaatta attggctttg ctatgtatgg 1081 atactttaaa aaggaaactc gtctttggct agatagattt atgattgatt acaaatatca 1141 aaataaaggc tatggaaaat cttctcttga attattgatt agcgttatga ttaatgaata 1201 taaatgcaat aaaatttatc taagtacatt taaagataat attggagcta taaaactata 1261 tgaaaaattt ggatttgaat ttaatggtga attcgatgaa aatggagaac ttataatggt 1321 attaaaggtt taattttaaa agtcaaatct atatttaaat aaaattaatt gaaattatat 1381 ataatctaat attgtttttt aaaactatat ccccttaatt tattatatat aataataaat 1441 taaggggtaa ttatttatag aataattttt aatttcaaat tgaattcact tatgaaaaat 1501 atcattttag tttaaagcaa acttattaag ttacgtaaaa acacctatac acaactttaa 1561 actattcttt taaattcaat atatagaaat cttggtacag tagatctatc atgaatattt 1621 tatttcttag aatttctcct ctattaatta acacttttaa cgcttcactt acttgtatag 1681 aagccactaa agctggtgta aaagaaggat tcccaaggac atcctctatg ccttttttac 1741 ttttattctt ataaataata tccaatgttc tatcacctgg aaatatagtt gttacttgtc 1801 cataccagcc tgcaatagca ccatgaataa atggtatttt aagtttctca caactttctt 1861 gtaataaaaa tctagtttct atattatcaa ccgcatcaat aactacatca tgttctttta 1921 aaatatctaa tacattatcc ttatttataa atgtcgtaac aggatttaca tatattaaat 1981 cattaactat tttcattctt tttttagctt ctatggcctt gttctttctt aaatttaaat 2041 tactactaat aatttgtcta ttcaaattag attcgctaaa attatcacca tctactactg 2101 ttatatagcc tatcccaatt cttcctagca tttcgattat atatccacct aatcctccac 2161 atccaattac gcagacttta aagtctttaa gtttttcatt ttcttctaaa gaaagagttt 2221 ttatatttct atcatatcta gacattctat cctcctccta ctggtgggaa taaagacaat 2281 acatccccat ccttcaataa agtatctacc tttccatctc tcccattaat aagtaatata 2341 gccacttctt ctactttaat atttaattct tcaagtatat gcctaggggt tatattttca 2401 ttatttattt ccataaaata ttttttatct cttccttctc taaaatatgc aaataatctt 2461 acttcaattt tcaaaaatcc acctccttat ctctatataa agctatagaa agacttttat 2521 tttttagctt taaaagcctt tctattttta agtatttact atctgttttt aatacatctt 2581 ggttttattt cataattatt tttatctgat tgtctattta tccgatggct acccgctcta 2641 atactcccat cttctccaaa gtgggagtaa agagcgggta cgtccctgga taacaatttc 2701 taagcttcag ttggagtaaa aactctctct gaagtcaaga actctgttta tatttcctac 2761 tttatatatt cttcaaggcc taattttttc aatgtatctt ctgttggtat accattcttg 2821 tcccatcctc ttactgcata atattctgga agtaattcac ttaatctatg aacacatccc 2881 ttagaaggtc cctccggaat aggttcttta agcaatcttt ttggaagggt atcatgggaa 2941 ctgtctatac cagcttctaa attaaataac ttttctaatg tccaaattct atctcctgct 3001 tccattatag attctgcatc atgtagctta ccacctacga ctacattata catatctaca 3061 taatcctgta ctccaagtcc aaaagttgta aatatacaca atcctaaaga atctattaca 3121 gctgttaagt cgtggaatat tttagcatag gctgcctttc cttctagaga gaatctgtca 3181 agtttttctg gatatcctag tatttccgga cttatcatat aaccttttat atgacaacca 3241 cctctattat taactgcata agttatacca tgtccttgaa ttcctcttgg gtcataggct 3301 ggtagttctt gctttttaac tgtcatagaa aactctggaa caccgtagga ttcacataat 3361 ctataggatc catctgccat cttatctcca aaaccttctc ttaatgccat tttctttgtc 3421 catccaacaa cagcctctgc atctccccat tttaaagata atccatcccc ttttatatcc 3481 tcatccttta tatatccttt ttcgtataac tccatggctg ctgcaatagt agctcctgcc 3541 gaaattgtat cgagaccata ttcattacaa agcatattag ctacattaat agcatttaga 3601 tcatatacat cacaatcaga tccaaaagac cataaagttt catattctgg gcccccacat 3661 tctgtaccat catctaattt tacccatcta ccacaggcta ttggacatct ataacatgga 3721 ttttttctta caagacaatc ctctgtaaga gtttctccac ttattttatc agcctcatct 3781 gtataggatt tttggaagtt tctcacggga tgcacaccat tttcattaat tatatttaca 3841 agtacagcag aaccataagt aggtaatcct ccacctgcaa ctggatcttc tcttaatatt 3901 ttaatttttt ctaaggatac tttttttgct tccccttcat taaacacttt aacttttcca 3961 gaacctttaa ccactatggc ttttaaattc tttgaaccca ttacagctcc aacgccacct 4021 cttcctgctg ctctatctat atcattcata atagctgcca taagagatag tttttctcct 4081 gcaggtccta tacatagtac ttttgctctt tcattatttt cattacaaag aatttttgta 4141 gtttctaatg aagtcttacc ccatagatga tctgcttctt ttatttctat tttatcatct 4201 tctatgttta cataaacagg tacctctgat ttaccttgta ctattatcat atcgtatcct 4261 gcatttttaa gttctgttcc ccattttcca ccagagtttg atattgcaat agtcccagtt 4321 aaaggagcct ttgttactac catatatcta ccactggttg gcataggagc tccagtaata 4381 ggaccagtaa ctataacaag tttattttca atagataatg gatctatttt agggtctatt 4441 tcttctaata aagtcttaac cccaagtcct ctagctccta taaatttttt agccttttct 4501 tcatctaaag gctctaaagt acaatttcta tttgttaaat caattcttaa aatctttcca 4561 ttataaccat acataaacaa atcctcctta taaaaattta tacattacta actataataa 4621 gcaagtttta tgccaaaaaa ttataattgt aaaaaagagg acatatatta tgtataaact 4681 aaaataccat acctatagtt attagtgata atatttgtac aaactctata aaaaccatat 4741 ttggtatatt taaaggcttc tatataccta gataagaact taactttatc taaagtcaaa 4801 ctatcttctt tgtatatatt aaaatatgtt gtataatata taccctgtct aaaaaaatat 4861 ttaaattata cttacttaaa attaatatta agaataacaa tcttttttgt tctatttaga 4921 tacatttttt tatgttttat tgttcttttt tggaactttg ttctatatta gtacagtgag 4981 tatttttcta tttttctata aagagtattt cttcctatac caagagcctt tgcagcggaa 5041 gaaacattac catcaaactt atttaatacc tctttaatgt ggtttttctc cacaatttca 5101 agattaaaca ccatagtttc ttcttttgcc ttatctctaa cttccttgct actataatgg 5161 tttatattat taataatttc aacactttct gcatttatta tcaattctac tatattttct 5221 aattccctta tattacctgg ccaatgataa ttcataagcc tttccatata tacagaaggt 5281 atttctacct ttcttttatt taaatgttta gatgttttat tcataaaata atctataagt 5341 aaaggtatat cctctcttct ttcttttaat gctggtaaat atactggtaa tacatttatt 5401 ctataaaata aatcctttct aaaatttccc ttctctacct cttctcctaa atccttatta 5461 gtggcagcta ttattctaga atttacaggt atttgtttag aacttcctat tctatttata 5521 acaccctctt ctataaccct taaaagtttt atctgcatat ctaaaggcat ttcccctatt 5581 tcatcaagaa atatggttcc accatgagaa ttttcaaatt ttcctctata tcctcctctt 5641 tttgctccag taaaggctcc ttcttcatat ccaaaaagtt cagattcaat tagatttctt 5701 gggatagctc cacaattaac agctataaaa ggcttatctt ttctatcact atagttgtgt 5761 attgactgtg caaaaacttc ctttcccgtt ccactatcac cggtaataag tatagtagat 5821 ctgctatctg caattttttt tgaataatct attatgctaa gaagtttttt gcttttacct 5881 ataattttgt caaaggtata gatagcttga ccactaagaa tttttcctgc aagtttccga 5941 gttttttgta tatctgaaag taaacaggtt acctcaataa ttctcatgga tgaatcatat 6001 ataggatatg cgcttaaatt caattgaagt ttatttttaa gacagtgtac atatacatct 6061 tcatctacaa aactaccttt gtcgtagatc tcatctaaaa ccatagacca gtcaggtatt 6121 aaatcccaca tcttcatact ttttatatca ttttcattaa aacctaaaag ttctatagcg 6181 ttgttattta tggtctttat tgcacctgac aaatccaccc ttaatatagc tctttgtata 6241 gaattaaata cattctcaat actctttttg gatatttgta aagctctatt ataatcattt 6301 aattctatca ttttttcaat ggcattagtt gcagccgcta ccattcctaa ggtatgagaa 6361 tgtacatttt cactatatcc tgtcaaatca agaatcccaa ttattttccc gttaatatct 6421 tttatgggag ctgcagaaca agtccatcta tgataagctt taacgtaatg gtcctctcca 6481 gatatctgaa ttggagattt ttcacttaaa gccatactca tggcgtttgt ccccatattt 6541 ttttcatcca tataagctcc tggaatcatt ttcacattag aagcttcctt taatatactt 6601 tcatctccta tgacatttaa tatgcaacca tccccatctg taagaataac gaaaaagtta 6661 gagcccttaa caaattggta gagcttattc ataaaaggtg tagcaataat aattaactct 6721 gaattattat ttagttccct tttaagttct tcatccttta ttattttttt actgtatact 6781 aaatctttgc taattcctaa actattacat ttttcatgag attttaatat acaaaatttc 6841 tcatttatga aattatcctt catataaatc ttccccttta agataaagac agcttatcaa 6901 ataattttaa tgctaaaaat cggataaaac ctctatttca tcttcaggtt taataaagcc 6961 ttcctttaat atttttgtaa aaataccctc cctaggcatt atgcaatccc ctataaggtt 7021 tcttatctca catcctgcat gacactcctt acctatttga gttacttcca taagcacttc 7081 tcctattttt aatttagttc caataggtaa ttcatacaaa atcaatccct ctgtggttat 7141 attttctgca aatttacctg tacataaccc ttgtagccct aactttttca ttttatctat 7201 actttctgta cctaaaagac ttacttgtct atgccagttt cctgcatgag catctcctac 7261 aagaccgtga tctactttaa ataacccctt atctatagga tgttttatct cacctttttt 7321 ttcacttata ttaactgcta ttacctttgc catgctataa ttcctccctt tgaaataatc 7381 ctgattttcc accacttttt ttcataagtt ttacatctga tattgtcatt tctctatcta 7441 tagctttgca catatcatag atagttaaag ctgctactgt aactgcagtt aaagcttcca 7501 tttctactcc tgttttccct gtattcttta ctgaagatgt tatatctata ttattgtttt 7561 caaaatccaa gttaaaattt atgtcacaac cgtttatcat tataggatgg cacataggta 7621 taatattagc cgtatttttt gctgccataa tacctgctac ttgagccaca gatagcacat 7681 ctccttttga tatagtacct tcttttattt tatttaaagt ttctttcttc atatttatat 7741 aaccataggc aatagcttct ctttctgtat ctcctttact gcctacatcc accatttttg 7801 ctcttccttg cttatttata tgtgttaatt ccataagcta acctccaatc tgatacatca 7861 tttttttgct tttactttct ttttcctcta tcatatgatg ctctaatggt ttattataaa 7921 tagtttcatt tatcttagac aaaagtgctt ggctactatc cacatagttt ttaagatcta 7981 cttccttttc agaatgaagg caaggtttca atgtgccctc tgaagttaat cttactctat 8041 tacagccact gcaaaattta caactcatag gacttataaa cccaatattt tctttggact 8101 ctttaaattt atataataga gcagtactac ttttatcagt ttccacaggt ataaggtcac 8161 tatgcttgga tattatttct tctgaactta tataaccatc tttgtataat tttctacctt 8221 ctcctatagg cataagctct ataaatctta cagatatggg atatttcttt gttaaattca 8281 taaaatcatc tatttcatca tcatttatgc ccttcattat tactgtatta atttttattg 8341 gtttcatacc aatggataaa gatttttcaa tgcttttaaa aactttatta atatccccac 8401 ctcttgtaat actcttaaac ctgtcttcct ttaaggaatc aagacttata ttaactcttt 8461 taagaccagc cttttttaat tcctctacca tatcttctaa aagtatagca ttggtagtca 8521 tggcaatgtc tttaatggaa tttatttttg atgtattata aattaattta tctatatctt 8581 taagtataag aggttctcca cctgtaaatc taattttatt tactcctaat aaactagctg 8641 acttaaccac cttaaatatc tcttcatatc tcattatgtt atcatgttct ttttttacaa 8701 taccttcagg tggcatacaa taaacacatc ttaaattgca tctatctgtt acagatactc 8761 ttaaatagtt aatttttctt ccatgcttgt ctaacatcaa acccctcctt tatataaagt 8821 ttactcttta gtagatgaaa catatttatc atttcttata taaaaacaat attacctgct 8881 tcactgtagt cataaccacc taattcatcc aatttctctt taaacttatc actttttata 8941 atacttataa attcttttat tgagggcata cttaaaaatt cttcaaaaat tactatatca 9001 tattcttcat tacaaacagg tataaaatct agtcccatca tatttgccgc agaatatatc 9061 ccaagtccac aatgggcatc tccatttgaa atagctgcag ctacttgtaa atgagtatac 9121 tcttcccttt catatccttt tatttctcta gggtttatat ttaatttttt aagattataa 9181 tcaaaaagaa gtcttgtacc tgcacccctt tgtctattta caaatttcaa ttttttatct 9241 cttatatccc taatagaagt aatattatta ggattcccct tagggaccat aattccttga 9301 attcttttta cgcattttat aagagccatt ggtctattcc caatatattt tttaatgtag 9361 cttacgttat attctccact ttccatatct aaaagatgta taggagctat atgggtttca 9421 ccatttttaa gtgccattat tcctcccata ctacctacat gagcagagga taaataatat 9481 tcaccctgtt ttacatgaat taaatctgct ataacatcta ttataggatc atgacttcct 9541 atacaaacta tagtattatt tatttcctct tcatccttta gaagttttat gtctacttcc 9601 gttccttttt cgataccttc cacattttgt ggaacttcaa gtattccatc tgctctaaca 9661 agagacatgg tggcaccagc tcccctattt aaaggtgtag ctactacttt ttctcctact 9721 ttacctaatt ttatccttac aaattcaaca tattttaatg aagacataac tctcttagat 9781 aatgtagctt taattttttt atatttataa ggtttttccc ctgcaaattt ttcaaccata 9841 ggtcttacaa agttctccat aataacataa gccgacacag gatatccagg tattcctata 9901 acaggtttat tatctatctt tcctaaaata accggtttcc ctggctttat agctactcca 9961 tgtatatata ccctacctaa atcttctata actttagctg tgtaatcctc tcttcctgca 10021 gaagaaccag catttacaag aactatatca cattctttta ctgctttttt tatagtatct 10081 ttaatttttt cataattatc tttaactatt tcatatcttt tagcgatgcc accatactca 10141 aaaacctgtg ctgcaaaggt tcttgagtta aaatctatta tatctcctac ttttaagttg 10201 ctacctggtt ctacaagttc tgtgccagta gggattatgc ctactagagg ttttttataa 10261 acttctactt catttactcc ccctgcaatc attgctgaaa tatccacagg tcttatttta 10321 tgataggatg gaactataag agatttctcc actatatcct ctcctaaagg tcttatgttt 10381 tcataagggg ctatactttt atatattttc acccttttat catctacttt aattaaatcc 10441 tccaccatta ttacagcatt atactctcta ggtataggat ctcctgtatc tactactata 10501 taatcctttt cttcttctaa agctatatga ttcttttcat ttgctcctaa ggttttttca 10561 ctattaaccg caataccatc catagcagaa gaattgtaga aaggagaaga tattttagaa 10621 tatataggtg atgcggttat tctattactt gaatattctg tatctataaa ttcattttgt 10681 ctttctatgc ttatcttact aaaataaaat tttaatgcct cttcaatttc ataatttgaa 10741 agataaatat tttgccccat attaaaacct cctaaaatct atatacaaat actttctcat 10801 ccttttttat tccctcaaga ttcttatcta tcttcataaa accataagcc ttagaaaatc 10861 cacttataag tccagattta gaaaatatag gtgatgcaat tatttcattc tctttccaat 10921 ttaatgttac tggtaaatat tcttctcttc cctttgcact atgataattt atattaaact 10981 tacaaactat aggaaaaacc ttttctttaa cacctgcaat tttatctata taatatttaa 11041 ctataacctt atatacaata gctgcagata gaggatgtcc tggtaatcca aaaactattt 11101 tatccttaac atttcctata atagttggtt taccaggttt tattgctatg ccatgaacaa 11161 aaactccagg atctcctaaa ctatttataa catctatagt aacatctttt tttcctacag 11221 aacttccccc agatataagt acaatatccg tatcttctat agctttttct actgtatttt 11281 ttagaagatt aaaatcatct cttataattc cataatttat aggaatacct ccatcttcaa 11341 taatggaagc ctgtaaaaga taagaattta tatctctaac ctcacctaga tttggctctt 11401 tattaggatc tactatctca tctcctgtag atattatagc taccttaggt ttcctacata 11461 caggcacttt agttattcca agactagata atacacctat ttcatagggt cttaatcttt 11521 tacctttttt tatcattatc tcttctttag ctatatcttc acctatttct actacctttt 11581 caccataggc tgtagcttta tttataagta ttgtatcctc atgaaccctt tctgtatatt 11641 ccaccataac tacagaatct gatccttctg gaatcatacc tcccgttgga acatacacac 11701 aatctccagg gaaatccata ttaacttcag gaattttccc catgaaaact tctcccctat 11761 agttcatcat agcaggcata ctttcactgg cacctgccac atccttagaa tttacagcat 11821 atccatctac tgtagatctt ctaaaattag gtacatttat atgagaaact atatcctcat 11881 atataaccct atccatacta cttaaaagtt ccacttcttc ctttatcggt tttacattaa 11941 aatttttttc tataagactt ttggcctctt taatagatac aacattaaat aagtccacta 12001 atattacctc cttaaaccat tctatctagc acattctgat gcctcaccta atagaatctc 12061 tattccatga ggtatagcac ctaatactgc ctgtaaattt tctgctgcag cttttgggct 12121 tcctggaagg tttattataa gagaatcttt tctaattcca gcaattcctc tagaaagtat 12181 agcctttggc gttatagaaa gggaactggt tctcatagct tcaccaaagc ctggtacatg 12241 tttttcgata accttttctg tagcctctgg agttacatcc cttttagaaa agcctgtacc 12301 tccattagta ataataagat ttactttctt ttcatcacat aactttataa gctctccact 12361 tataatgttg atttcatctg gtattatttt ataatcctct actttatatc cttctttttc 12421 taaaatatcc tgtagtacct ttcctgtttc gtcttttctc tcgccctttg aacccttatc 12481 acttattgta acaatagcag tctttatcat aattattccc cctatacatt gattaattct 12541 atttagttat aacataagtt acttataatc tacttaacct atgatttatc atttaattta 12601 taacttctaa ctcttagaat aagaaaatag ttcacttata aagtgttcaa acccatttgc 12661 atatctattt taaatttgcc ttatgtcata attagcactt taattctgcc tttacttatt 12721 taacatcatc ttaactttag cattcttagg attattaaat atattgtctg tttcaccctg 12781 ttctataatt ttacccttat ccataaatat tacataatcc gcaattctct ctgcttgata 12841 aaaatcatga gttacaaaaa ttacggttct tttatctttc ataatatctt taattaaagt 12901 ttcagaagct aaagtgcttt ctatatccat acttgcagta ggttcatcta atattataac 12961 atcattttct aatataactg ttctaagtaa ggctaccttt tgagcttctc ctccagataa 13021 ttttttcccg tttttattaa ggatttcatt tatattaaaa tattttatgt atttttcaaa 13081 cctagcatca acagtttttc taggtgtttt cctaaattta agtcccatta taatattttc 13141 acctgcagaa caattaaata aaagtggtct ttgagccatc atagaaattt tatcttttac 13201 tttattgaaa tcttttccat cataaataat ttccccttca tttaatttgt taaatcctgc 13261 tatgctttgt aataaagtac tctttccact tccatttaat cctaatattc catatatact 13321 tccctcttta aaaaccatat gctctatatc taatactttc ctaccaacat actcttttac 13381 tgcattaact acctctattt tcaaaaactt tcactccctt gaaaaaaatg aagaatagca 13441 ttaattataa aagatataac tagtaatatt cctcctattg ctaaagcttc attaaaatta 13501 cctttgcctg tctccaatgc aatatatgtg gtcataaccc ttgtaaatcc tttaatattt 13561 cctcctacta tcataactgc accaacttca gatatagctc ttccaaaggc tgctgttaca 13621 actgatagta attgtatctt gttttctttt ataataatta aaaaggtttg aaatctatta 13681 gctcctaatg tggtacatgt attttttata tctttaccac tttttactat aatagatata 13741 ctaagaccaa atactatagg aaatataagt gatgtctggg ctattatcat agcggtagga 13801 gtaaacaata attcaaattc acctaaaggt ccctttctcg ataataaaag ataaaccaat 13861 aaccccataa gaactggtgg tatactcatt aaagtatgat taatttgaat tataatcttt 13921 tttaatttga agtttaataa agcacaggga atgcctaaaa gcattcccaa tattgaagcg 13981 attaaagttg aagttaatga aacataaaga gacattaata ccacaggaat aatttctttt 14041 aaatttatta tattaaaaat ttcctgctcc ataatatcac ctatttcttt ccgttagcta 14101 caaaaagcgc ttgtccgtat ttttcttttc catactctcc tataagtttt tgccctttat 14161 cagaaagcat ccaatctata tattccttgg cttccttttc tttaatttta ttcttttcag 14221 tatttaacat tataactcca tactgattat ataaatcatt acttttctca gttacaatta 14281 ctaaatctaa tttatccttc atagacaaat aagtagctct atctgttaaa gtataggcct 14341 ttttttcatt tgccatctgt aatactgctc ccataccttt acctgcactt atataccatt 14401 ctcccttagg atctacttta atatctttcc aaagcttctt ttctttagta tgagttcctg 14461 attcatctcc tctagaaaca aaactagctt tattttcatc aattaattta aaagcttctg 14521 ctgcattatt aggagctttt tcttttaact ttgcagtatc ttcctttggg ccaactataa 14581 taaaatcatt gtacataaca tcatgtcttt cagtaccata acctttttta ataaactctt 14641 cttctttagc tttagcatga actagaagac aatctgcatc accattttgt ccaagtttaa 14701 gagcttcacc agttcccttt gcaactacct taacatctat tcctgtatcc tttttaaact 14761 caggaagcaa ataatctaaa agtcctgaat cttgagtact ggtagttgta gccagtatca 14821 tagtcctact cttatcctct tccttagtac tttctgtaga attactttta tcacaggcca 14881 ctaaacttaa tgttaaaaaa ataccagata aaagtaacaa aatttttttc atgaaaacat 14941 ccccctcatt gtacttatta agtatataga atattctgta ttttccgcat attaaattat 15001 aaaaaaatac aaaatattat atactctaca ttatataata ttttgtacca ttataacaca 15061 tttttatata atttttttat aaatctatta aatttataat tttcgttcca ttttggaaca 15121 ttttattttt aagccctata aaaatttaac attaactaat agatctataa tatatcattc 15181 ctactatatc tgctataatc caccctatag gaattgccca ccaaattccc tttaatccta 15241 aataaggagc tgtaataaaa gcaagggcca ctctgagacc aagggatatt attgtcaaaa 15301 ctatggacat tttaacctta cctaaacctc tatataaacc ataaaacata aataagtaac 15361 ctatgaagca ataaaatgta catacaattc gtaaatactg tattcctatt tttataacct 15421 gagtttctgt aggatttata aatattaaca taaatttatc tgccataatc catacaacta 15481 aagatataaa aatacaaaat atagttataa tctttaaaga tactttgata ccacttttga 15541 ttctttcatc tttctctgct cctttgtttt gggcaatata agtagagaaa gcatttccaa 15601 agtcttgtac aggcatataa gcaaaggaat caatcttaac tgctgccgca aaggctgcca 15661 taggcgctat accaaaggaa tttaccaatc cctgtatcat taatattcca aaattcataa 15721 tagattgttg tattgatgta agcatggaat aactggcagt tagcttaaat atttctttat 15781 caaatttaat ttcacttagt ttaaactcta agaaatctag cttttttata caatatacaa 15841 tacacaaaat agccgaaaca aattgggcaa taactgtagc tagagccgcc ccagataccc 15901 ccatattaaa agtaattaca aatacaagat ctaatactat gtttataata gcagctaaaa 15961 tcaaaaaata taatgggact ttagaatttc caagagccct taaaagacct gccgcccaat 16021 tatataaaaa tgtaaaaaat ataccactaa atattatctt aagataactt ctagtatcta 16081 caaataactc tttaggaatt ttcataaata aaataatctg atctacaaat attaaggata 16141 atgcacttat tataattgaa gtaattccta taaaaataaa ggatgtagat atactagcct 16201 ttaacttatt tatctttttc ccgccaaaaa attgtgaaaa cacaatagaa gtacccatgc 16261 ataatcccag taaaatggat gttataaaaa ccataatagc aaaggaagag cctacagcgg 16321 ctaaagcctt tgtacctata aatttcccta ctattattga atctacaaca ttatataatt 16381 gctgaaatat atttcctact atcataggta atgaaaactt aagtattact tttaaaggag 16441 atcccttagt taaatcttta gttgtgctac tcattattct tctccaaatc taatgtataa 16501 atcaaaattc cctagggtaa gatctggcaa aagaagcttg tccttacaat aatgtgtatt 16561 aaatctcata aattctttaa cttcaacatg ggaagttaaa aaataaacct tttgggcatc 16621 acctaaagat atgcttttta atattgaatt ttctgtttct aatataatca ttccctcttc 16681 atcctatctt ctttatcttt aaggaaatta gaaaataact tctacttcat aacataaaaa 16741 agttttatat tattttttta atattatttt atttccaatg tttagtttat cataggatgc 16801 tatatatttg aacacttact tttaaatctt atgtgatgtg gctccataaa actactaaat 16861 cataagcaaa ttttaataat gactcttttt gctagttttc tttatctagc acttataaat 16921 aatttgtttt taacccattc caaattttca ttgtatacaa tgctaataca cttattgata 16981 aacaaagtat tataatactc aatgaagatt ctttataact tatgcccata taactataaa 17041 tagctattat aggtatatta gaaataatta ttgttaatat atattttata tagctcaatc 17101 ctaatgatga ggataaaaag catattacat ccgtaggcgc tatagggcat gctataccta 17161 aggctaaaaa tctaaaatta tattttttta ttaatggctc tacataatca tacttctttt 17221 taattaaatt ttttatattc caattagaaa atactctagc tatcacatat actaaagtct 17281 cacttaaaac cattcctacc atagataata aaaatccgtt agttgttcca aataaagtac 17341 cacctaatat tattaatgta aatcctggta ataaaatagg caatcttact atccatagta 17401 aaacaaaaat agccattatc cctactttat ttgaatctaa atatcctttc ataatttcta 17461 tggtaagtga tataaaatca tacttattaa atatatatat tgatataatc catactatac 17521 ataaagtaaa aactaagtat tttttattta tcttcataat tccctcctta atctcatcct 17581 attatttctt aaataaaagt ataaaaatct ttattttttc tccataaata ctttcttaat 17641 aagaagcaaa atttctaagc attagttatt ataagacaac acttataaaa atatgttaat 17701 aaaattcaga tggagagaca atttatcata attcaactcc atctgaacct ataaaatcat 17761 tgaataaata cttaaatttc agtattttta aattttattt attatgttaa agcatctatt 17821 ttaataagtt taattttcta tttataaata atatgtgaca gttaattttt gaagtttttt 17881 atttaacttt aaacttctta ttgtctaaat ttataattac atcagacata gatgcaattt 17941 ctaaggaatg agttaccatt attatgcatt tattatcttc atgagctaac ttttgaaaaa 18001 gctttattat atctacagag gttttactat ctaaatttcc tgtaggctca tctgctagta 18061 taatcttagc attagtagat aaagctctag ctattgctac cctttgttgc tgtcctccac 18121 taagatttaa tacacttctt tccccttctt ctcttttaag gcctaccttt tctattaatt 18181 cataggcctt ttgttttcta tctgggattt cattcctagt aatttccata gcagtaacta 18241 tattttgtat acctgtcatg taattaatta aattgtatgc ttgaaatact atccctatat 18301 attggtttct atagttggtt aaaccaattt tcttaatatc cttaccttca tataagattt 18361 caccactttt aggactatcc aatgcgcttg ccaatgataa agcagttgtt tttcctgatc 18421 cagaagctcc taatatagtg taaaatttac cactttcgaa attaaaatct acactttcta 18481 aaattattag ctcttttcct gcatctttat aactataatt tacattttta aattctaaaa 18541 ctgtattcat //