LOCUS NC_009495:12 18470 bp DNA linear BCT 08-SEP-2013 DEFINITION Clostridium botulinum A str. ATCC 3502 chromosome, complete genome. ACCESSION NC_009495 SOURCE Clostridium botulinum A str. ATCC 3502 chromosome, complete genome. COMMENT locus start: 2085000; locus end: 2103469 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.096843; n0_4mer:D = 19.986219; n0_4mer:PS = 26.638446 FEATURES Location/Qualifiers source 1..18470 /organism="Clostridium botulinum A str. ATCC 3502 chromosome, complete genome." gene complement(218..379) /gene="" /locus_tag="" /db_xref="2085217..2085378" CDS complement(218..379) /gene="" /product="hypothetical protein" /translation="VRGEASYAESFRTNVSGEFVHIEGILTKANGNTLHAEGIEISRN GHIGPHILG" gene 833..1831 /gene="" /locus_tag="" /db_xref="2085832..2086830" CDS 833..1831 /gene="" /product="leucine-rich repeat-containing protein" /translation="VKKKKIFLMIFCLIIITSTVLIYNHNKTKVTPTEANVQKVQSEK NSSQNNVNNNKNSKNNSGNKEALEEDEKNNDSETRETETPTIIKNNNSKNLDYVKNLD KISSLEIVDSAIERIDKLKGRDNIKTLKIVHCNVKDLEIISTLKNLENLEIIDCKLND VSIVKNLKNLKRLDISNNEINNLNGLENLTNLKELYMSNNNIADLKPIHNLLNLTNLD ISDNKITSIKELKNMKSIKELNICNNNLSNLEGIENMSKITGLWASNNKINNISILSN KNEIVNLSLDNNKISDISTISNFRKLKSLKLDKNNISNYKPLKDIYINLVDPDFSI" gene 1853..3901 /gene="" /locus_tag="" /db_xref="2086852..2088900" CDS 1853..3901 /gene="" /product="secreted carbohydrate-binding protein" /translation="MKKNLLPKLVLPILVASSTIIGANNTKVSAAPINDAGVKLTQPD GQVIQCYSSGDEFYNYLHDSDGRAIVKDEKTGYYVYGKYVKNKVQPSRERVTKTNIEN LKQIDSDSRVNMKDVKLPKDEIKERRKLLNADKPVQRTKNIGKLNNIVIFIKFSDQDE FKTSLSKYDTEFNSKDQASVNNYFKEISYNKSDINTSFYPKPNGDIILSYTDSHPRSY YTNVPESQQAMKEQTLLKNAVESVRSQIPSDLNVDSDNDGMVDNVCFIIKGATTGWSS LLWPHKWNMFYHDVRINGKRIDTYNFQLEDFINTQGVGVLSHEMFHTLGAPDLYHYNY DGKVAVGPWDVMDQTAPTPQSTGAYMKMTYGKWIDDIKEISKPGKYSINKIGNESNNS YIIKSPNSDKEYFAVEYRKREGKYDSNLPGEGLLVYRINTAYAGMGNANGGDEIYLYR PNASYTAEALASAAFGYNRSSINSKELFLSDGRDSGISLKNINTSGNTANFDVVINGQ TGNGETGDEKLPLKYNVNFNDTKTLSKAEDISGECVYGKKINNIELYLNGSKYMDAER GRLNDSENKYKGYDLSKAAFKFSVDFSKFSDGNYPYEIRVTTEDGQKISIKQGYLKVK KQTGGTEDKDIKEWKPGTSYKVGDIVTYNNYKYKCLQAHNAIVTWEPSKTPALWARIY" gene complement(4063..6153) /gene="" /locus_tag="" /db_xref="2089062..2091152" CDS complement(4063..6153) /gene="" /product="sigma-54 dependent transcriptional regulator" /translation="MRKLWRNHEGIMKKTMSVVALDARAGEFYAKEINELFGEYVEIA SYNVSDGSAVGTLPKADLFVISTDAYGSAEEVARHVPIDSLTMGIEVSYRWSTLQNLS MIPKGTRALFVNMTDTMAREAIAQLQQLGVNHIRFIPFYPGAVLEEPVDMAVTPEEER YVPQSVKKVLNIGHRSCTSGMMIEIALRMGLEQLLETKKFQNYFQAMATNNYSFNQIY ARSRRLESQFHILMEILDEGLVGVNEKGEIFACNKKACQIAKIAENLVIGRCGEKVFP YIPFYSALKDKKEIPPKVIKLGGVNVSIEVIPVLRQKKCIGAFATLQEFSELESKQNE LRSQLLKKGYCAKYTFNDVIGESDCICHTKSILKRMAATESPVLIVGETGTGKELLAH AVHCASKRSKGPFIAINVAAMPENLLESELFGYEEGAFTGAKKGGRPGLFEFAHGGTL FLDEVEGMSQAMQVKLLRVLQEGEVMRVGGSRILSVDVRIVAATNESLEQKVEEGSFR KDLYYRLNTLTVVVPLLQERGEDVFLLMEHFKEELRGDFKLSEEVKDFLRQYSWPGNI RELHNTVEYFVYTGKQVIDMDDLPPTIFHDRTSRPVNVEKKERLQEVVSPFWFVLEQL YMAAERNEFIGRDKLLLKAKKQYLLLSQKEIRDILKDMEKKGFVKIGKGRGGSRITLK GKEYCQSRDKSLDK" gene complement(6516..6770) /gene="" /locus_tag="" /db_xref="2091515..2091769" CDS complement(6516..6770) /gene="" /product="hypothetical protein" /translation="MKITVIGSHLCPDTLAALNKLSAVGADIDFKDILSCHADLKEYL KLRDTNALYDEIRGTESLGIPCFVLENNEMTMDIKKALEG" gene complement(6783..7151) /gene="" /locus_tag="" /db_xref="2091782..2092150" CDS complement(6783..7151) /gene="" /product="endoribonuclease L-PSP" /translation="MKIIETTKAPGAIGPYSQGYEVNGIVYTSGQIPVNPENGEIAEK IAEQAKQSCENVGAILEAAGTRFEKVFKTTCFLADMEDFADFNDVYAKYFVSNPARSC IAVKTLPKGVLCEIEAIAVK" gene complement(7193..8464) /gene="" /locus_tag="" /db_xref="2092192..2093463" CDS complement(7193..8464) /gene="" /product="sodium:dicarboxylate symporter" /translation="MGKKKIWESYRSPLILLGGIIAGAILGVVLGEKATVFEPLGNIF INLMFTIVVPMVFVSIATAVGSMLNMKRLGKILGSLMLTFVVTGCFAAVLVLVVVNIW SPAANTAIAMESAKVQESASISSMIVGSLTVDDFSGLMSRKNMLPIIVFAIISGLAVS ACGGEESAVGKLLENLNRVIMRIVEMIMKLAPIGLGAYFANLIGKFGPQLIGDYGRTM LIYYPMCLVYGMVFYPAYTYFAGGRLGVKKMLQNILDPAVTSFATQSSVATLPVNMKA CKNIGVPEDIYNIVLPMGATMHMDGSVISSITKIAFLFGVFKMPFTGMGTYAMAVLVS ILSAFVLSGAPGGGLVGEMLIVSFFGFPGEAFPLIATIGFLVDPAATCLNSSGDTIAS MIIARFVEGKDWLLKGEINKEGEINKIEISC" gene complement(8510..9679) /gene="" /locus_tag="" /db_xref="2093509..2094678" CDS complement(8510..9679) /gene="" /product="aminotransferase, classes I and II" /translation="MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTA QPIIDACKRKAEEGVWGYTSRPDSYFKAVQEWEKRRNQWDVDVSLMSWSLGVVPALSA IVKIFSHTGDKILIQTPVYSEFYDITEAWARVVVENQFIEKNGKWHIDFEDFEKKAKE CKIFLLCNPHNPLGIVWEPEELKRMAEICIANDVLLVSDEIHSDLIFHGKKHMPTATL SKEISKKIITCVSATKTFNLAGLQASTTIFPNEQMKQKFDGFWMNMDIQRNNAFSSVA MEAAYNEGEEWLTQLLAYVSENFDFIKKYFDENIPKIKPNVPDATYLVWLDCRELGMS NEELRDFMIHKVGLGLNEGCSFGRSLSGYMRLNAACPRSVLEQALKQLKEAIDKL" gene 9993..11285 /gene="" /locus_tag="" /db_xref="2094992..2096284" CDS 9993..11285 /gene="" /product="hypothetical protein" /translation="MLTKENLLALLKQEVVPALGCTEPVCVALATADAYHAIGGRIVS IKIEVNPGIYKNGMSVGIPGFDRVGLKYAASLGAVIGNPEKKLELLEDITAEVSQKAI KIVENSQVVVVIKHEEAQLYVRAEIITTAGMGISEIRGTHSNIIFTKRNNDMLLQKEY SVDSDDSLHQQLKLMGIAEIRKLIDECKEEELSFLLDGVDMNERLADYGLEHSLGIGI ASALQEKMTTDIMGDNLFSRTMLRVASSAEGRMSGCPYAVMSSAGSGNHGITAILPVT EMARYLNSSREQLVKALAFSHTLNVYIKLFTGKLSATCGCGVSAATAASAAMVWLMGG NEHQIANAIINMSGNLTGMICDGGKIGCALKLATATNAALMCAYLAMSDVALQPSDGI CDVTAEQVIRNMGQVSNPGMVETDQTILSIMIEKDQRK" gene 11625..12620 /gene="" /locus_tag="" /db_xref="2096624..2097619" CDS 11625..12620 /gene="" /product="leucine-rich repeat-containing protein" /translation="VKKRKISIIIVCLIIITSITLIYNHNKTKKTQTDSNIQKVQSKK NSSGTNIKNNNNSKNNSKKKETSEKETNQNSKINKDEISSVIKNNDAKNLDNVKNLDK ISSLEIIDSGIEHIDKLKGKENIKALKIVHCNIKDLEIISTLKNLENLEIIDCNLNDV SIVKNLKQLKRLDISNNQVSNLEGIGNLTNLKELYMSNNNITNIEPMYKLLKLTNLDI SDNKINNIKELKNMKSIKELNICNNNVSSLEGIENMEHLVGLWTSSNKINNISILSNK NQIVNLSLDNNKISDISVISNLKKLKSLKLDKNNISNYKPLKGIYKNLVEPDFSI" gene 12641..14860 /gene="" /locus_tag="" /db_xref="2097640..2099859" CDS 12641..14860 /gene="" /product="secreted protein" /translation="MKKNLLPKLVLPILVASSTIIGANQTKVSAAPIKDAEVKLTQPD GQVVQCYASGDEFYNYLHDSNGRAIVKDEKTGYYVYGKYVKNKVQPSRERVTKSNIET LKQIDADSKVNMKDVKAPKNEIEKQREFLNANNPIQRTKNIGQLNNIVIFIKFSDQDE ITRDFSTYNKQFNSKNQASLNNYYKEVSYNKLDVNTTFYPKPNGDKVLSYTDSHPRSY YTNVPQNERAAREQTLLKNAVDSVKSEIPSDLNVDSDNDGKVDNVCFIVKGATTGWSS LLWPHKWNMFYQDVRINGKKIDTYNFQLEDFIGDNGIGVLSHEMFHTLGAPDLYHYNY DGKVAVGPWDVMDQTASIPQSMGTYMKMYYGKWLNNINEINKPGKYSINKIGTEANNS YIIKSPNSNKEYFVVEYRKNEGQYESNLPGEGLLVYRINTAFQGRGNSSGNDEVYLYR QNGSLNNVGDISRAALAYNKTSINSKELFLSDGSDSGISLENINVLGNTANFNVVING QTADSKTVDKNLPLKHQVNFDDTKTLSNTENIIGECVYGKKINNIELYINGYKYMDAE RSKLNDPGNKYKGYDLSKAAFKFSMDFSRWYESNYPYEIKVTTEDGQRISIKKGYLRV KKQENSKNLAFKGNFNLGNNEALYGARTLTGECVYGKGIKAVKLYVNGYPYVDAKRYA INDPQNKYTGYDLSKAGFKFDLYFSNWHNYDYPYKVVAIDSEGNEMLIKEGHLKVRN" gene complement(15061..16500) /gene="" /locus_tag="" /db_xref="2100060..2101499" CDS complement(15061..16500) /gene="" /product="sensor histidine kinase" /translation="LRNKLKKSIVYKLFLVTTLLLVISSICTYSIIYMLLPNYYHKYK KMTIENQLDSIVDNVPKLDINNIEEYLGQISFNNNANIVVTDEYGNVIYFTNVLQKGL VTIPKKEDLSHFKNIEKTNTRSVYTSYRKIKFYNSEEKYNLYLTAPLQPVSEASKVLF LLIPYIGLVVILISVIGGLIYSKVISKPLISMNKVAKEMAKLDFTKKCTVKGEDEIGE LSQSLNDLSNNLRISMEELQRANEQLLDDIAKEREIEKKRREFIATISHELKTPITIL KGQIEGMLSNIGIYKDRDKYLKRNLEVLNDMEYMVKETLEISKLESQGFKPRKEQISL SKIVEECIYNISFIAKRKNIFIDKNINEDLFVHGDSKLLKKVVNNIITNAINHSPESE KVYANLHEEKDEIVLKVENTGTYIEENELKEIFKPFYRIEKSRNRKSGGSGLGLYIVK MILDAHNGKYSISNNEKGVEFKLCLKKYS" gene complement(16490..17155) /gene="" /locus_tag="" /db_xref="2101489..2102154" CDS complement(16490..17155) /gene="" /product="DNA-binding response regulator" /translation="MPKRILVVEDDFDIHTIISEVLKESGYLVEVATDGLIAVEMFRR GNFDLIILDVMLPKIDGFVVCEIIRKESSMPIIMLTALGEEEDEMKGFELKVDDYITK PFSINLLIKRVEAVLRRANGLEENNSTLTFEEITIYPSNYKTLVNNKEIELTYKEFQI LEILISNVGRVFSRESLLNQIWGYDYFGDTRVIDTHIKNLRQKLNIDYIKTIRGVGYK IEK" gene complement(17655..18470) /gene="" /locus_tag="" /db_xref="2102654..2103469" CDS complement(17655..18470) /gene="" /product="hypothetical protein" /translation="MPFKHEKITYGFPQDPYDNSIIKELCEDINCALNFSRKPVGIKL YFDKEEYSKLEWKEPNAPLSYCCVVEKATRGKAFKIRLEHLSCDGGTTALNLEPSTER IESGAEYFSYNLYKTPAAARRVREGVPGLYRTGATTYGVAVGPLEEFETTPDVVIFIV NPYQAMRIQQGYVYHEGGRLEITGASMQAICAEATVEPYIKGRLNTTVLCPSTRFLAK WKDEEMAIGIPFERFQSVVEGVIATINTTDIKRRKDEIKQRFAKKNKEINLEY" ORIGIN 1 gtaagccctt ggccaatctt caatacagag atccgttcca ttgacgtaat tgccccatgt 61 aaagaggagt attattgcct tacggaagtc ctccacctat tgttactata cctgtgaaac 121 aaggattatc gttatttagt attttggctg ctatacttct ataatcacct gtgtcgtttg 181 ccagaagcca tgaaaaatct gaatttgcgt ctccatacta acctaatata tgaggaccaa 241 tatgtccatt tctacttatt tcaatcccct cggcatgtaa agtatttccg ttagcttttg 301 tgagtattcc ttctatatgg acaaattctc cacttacatt tgtcctaaaa ctttcagcat 361 aggatgcttc ccctctcact tctgtgattt aaccttcggc attagcaaca ctaccgcttg 421 ctattgttat tatcccttct gcatgggatg actttccact tgctactgtt tcaaacccct 481 ctgcatagga ccctcgcctt tagtatctat acctgatatt ataaaatcac cttccacata 541 tgaacgattc ccaattgccc atgttttgca acctccactg gtttttgtat cgcaatctcc 601 agagatacta atgtcgccgc cttctgtatt ggcttattca attgacgtgg aaaaagaatc 661 tgtattttta actctatctt tgtgataatt atcaggtgat ttctgtattt tttataacta 721 atataacttt atataattta tataaagttt cgagaaataa ttgcaataat aagtaaaaat 781 tggtatacta gcaacaaata gtaaaaattt tccggaaata gaggtgaaaa aagtgaaaaa 841 gaaaaagatt tttttaatga tattttgtct aattataatt acatctacag ttttaattta 901 taatcacaat aaaactaaag ttactcctac tgaggcaaat gtacaaaaag ttcagtctga 961 aaaaaattca tctcaaaaca atgtaaacaa taataaaaat tctaaaaata attctggtaa 1021 taaggaagcc cttgaagaag atgaaaaaaa taatgattca gaaactaggg aaacagaaac 1081 acctactatt attaaaaaca ataattcaaa gaacttagac tatgtgaaaa atttagataa 1141 aatatcctca ttagaaattg ttgatagtgc catagagcga atagacaaat taaaaggaag 1201 ggataatatt aaaactttaa aaatagttca ctgcaatgta aaagatttag agattatatc 1261 tacattaaag aaccttgaga atttagaaat tatagattgt aagttaaatg atgtatcaat 1321 agttaaaaac ttaaaaaact taaaaagatt agatattagc aataatgaaa taaataattt 1381 aaacggatta gaaaatctaa caaatttaaa agaactttat atgtcaaaca ataatatagc 1441 agatctaaaa ccaattcata acttacttaa cctaaccaat ttagatatta gtgataataa 1501 aattactagc attaaagaat taaaaaatat gaaatccatt aaagaactta atatatgcaa 1561 caacaatcta tctaatttag aaggaataga aaatatgagt aaaattacag gtctttgggc 1621 tagtaacaat aaaataaata atatttctat actttcaaat aaaaatgaaa tagtaaattt 1681 atcactagat aataataaaa tatcagacat atcaactata agtaacttta gaaaattgaa 1741 atctctgaaa ctagataaaa ataatatatc aaattataaa ccattaaaag atatatatat 1801 aaatctagtt gacccagatt tttcaatata aaataaaaaa gggggaaaaa taatgaaaaa 1861 gaatctttta cccaaattag ttttaccaat tttagttgca tcatctacta ttataggggc 1921 aaataatacc aaagtcagtg ctgcacctat aaatgatgca ggagtaaaat taactcaacc 1981 tgatggacaa gttattcaat gttactcatc aggagatgaa ttctataact atttacatga 2041 ttcagatgga agagctatag ttaaagatga aaaaacaggt tattatgtct atggaaaata 2101 tgtaaaaaat aaggtacaac catccagaga aagagtaaca aagactaata ttgaaaattt 2161 aaaacaaatt gattctgata gcagagttaa tatgaaagat gttaaacttc caaaggatga 2221 aataaaagaa cgaagaaaat tactcaatgc agataagcca gttcagagga caaaaaatat 2281 tggaaaactt aataatatag ttatttttat aaaatttagt gatcaagatg aatttaaaac 2341 aagtttatct aaatatgata ctgaatttaa ttcaaaagac caagcatctg taaataatta 2401 ttttaaagaa atatcctata ataaatcaga tatcaataca agtttttacc ctaaacctaa 2461 tggggatatc attttaagct atactgatag tcatccgaga agttattata ctaatgttcc 2521 agaaagccaa caagcaatga aagaacaaac cttacttaaa aatgctgtag aatctgttag 2581 aagtcaaatt ccaagtgatt taaatgtgga ctcagataat gatggtatgg ttgataacgt 2641 atgctttatt ataaaaggtg caacaactgg atggtcatca cttttatggc cacataaatg 2701 gaatatgttc taccatgatg taagaataaa tggcaaaaga atagatacct ataacttcca 2761 gttagaagat tttataaata ctcaaggtgt tggagtttta agccatgaaa tgttccatac 2821 attaggagca ccagatcttt atcactataa ttatgatggc aaagtcgctg taggaccatg 2881 ggatgtaatg gatcaaactg ctcctacccc tcaatcaaca ggagcctaca tgaaaatgac 2941 ctatggaaaa tggattgatg atataaaaga aataagtaag ccaggaaaat attcaataaa 3001 caaaataggt aatgaatcta ataatagtta tataataaaa tcaccaaatt cagataaaga 3061 atatttcgca gtagaataca gaaaaagaga aggaaaatat gattcaaatt tacctggaga 3121 aggattatta gtttatagaa ttaatacagc ttatgcaggt atgggtaatg ccaatggtgg 3181 tgatgaaata tatttatata gaccaaatgc aagttatact gctgaagctc tagctagtgc 3241 agcctttggc tataatagat caagcataaa ttcaaaagaa ttattcttat cagatggaag 3301 agatagtgga ataagtttaa aaaatattaa tacgtcagga aatactgcta atttcgatgt 3361 tgttataaat ggacaaactg gtaatggcga aactggagat gaaaaactac cacttaaata 3421 taatgtaaac tttaacgata ctaaaacatt atcaaaagct gaagatataa gcggtgaatg 3481 tgtatatgga aagaaaatta ataatataga attatattta aatggctcta aatatatgga 3541 tgctgaacgt ggtagattaa atgattcaga aaataaatat aaaggttatg acttatctaa 3601 agctgccttt aaattttcag tagacttttc aaaattctct gatggaaatt atccatacga 3661 aataagagta actactgaag atggtcaaaa aatttcaatt aaacaaggtt atttaaaggt 3721 aaaaaaacaa actggcggta cagaagataa ggacattaag gaatggaaac ctggtacaag 3781 ctataaagtt ggcgatatag taacttataa taattataaa tataaatgcc ttcaagctca 3841 taatgccata gttacttggg agccatcaaa aacaccagct ctttgggcaa gaatttatta 3901 aatataaact tataattaat cacactgctc taagataaaa acactaatta attgttttaa 3961 agaatataaa taaaaaattt atttatcact ataatttaag actcataaaa ggcagtgcta 4021 agtatattat aacttggcac tgctttcttt ctatatgttt ttctacttat ccaaagactt 4081 atcccgactc tgacagtatt ccttcccctt caaggtaatc ctgctgccgc ctcttccttt 4141 tccgattttt acgaaacctt ttttctccat atcctttaaa atatcccgaa tctccttttg 4201 ggacaataga agatactgct tcttcgcctt caacagcaac ttatcccttc cgataaactc 4261 attcctctct gctgccatat aaagctgttc cagaacaaac cagaagggcg aaaccacctc 4321 ctgcagtctc tccttcttct ccacattcac cggtctggat gtccggtcat ggaaaatagt 4381 aggcggtaaa tcatccatat caatcacctg tttcccggta taaacaaaat attccactgt 4441 gttatgcagt tcccggatat ttcccggcca ggaatactga cgcagaaagt ctttcacttc 4501 ctccgataac ttaaagtcac cccggagctc ctctttaaaa tgctccatca aaagaaagac 4561 atcctctccc cgttcctgta acagcggtac tacaaccgtc aaagtattca gacgataata 4621 cagatccttt cggaagcttc cttcctccac cttctgctcc aaagattcat tggttgctgc 4681 aacaattcta acatcaacac ttaggattct gctgccacct acacgcatga cttcgccttc 4741 ctgcagaact ctcagaagct ttacctgcat agcctggctc ataccttcta cttcatcgag 4801 gaataaggta ccaccatggg caaattcaaa cagcccaggg cgtccgcctt ttttcgcacc 4861 ggtaaatgcg ccctcttcat agccgaaaag ctcgctttcc agaagatttt ccggcatggc 4921 tgccacatta atggcaataa aaggaccttt gcttcgctta gatgcacaat gcaccgcatg 4981 agccagcagt tcttttcccg ttcctgtttc acctacaatt aaaactggac tttcggtagc 5041 cgccatccgt ttcaaaatac tctttgtatg gcagatacaa tctgattctc cgattacatc 5101 attaaaggta tacttggcac aataaccctt ttttagaagc tggcttctta actcattctg 5161 tttggattcc agctcactaa attcctgtag ggtagcaaat gcaccgatgc atttcttctg 5221 ccgcagaacc ggtataactt caatacttac gtttacgcca cccagcttaa tcactttagg 5281 cggaatttct ttcttatcct tcaatgcact gtaaaaggga atatagggaa atactttttc 5341 cccgcacctg ccaataacaa gattttccgc aatttttgca atctggcagg ctttcttatt 5401 gcatgcaaaa atctccccct tttcattaac gcctaccaat ccctcatcca atatttccat 5461 taaaatatgg aattggcttt ccagtcttct agagcgggca tatatctgat taaagctgta 5521 attattcgtt gccatcgcct ggaaataatt ttggaatttt ttcgtctcta acaactgttc 5581 aagtcccata cgcaaggcaa tctcgatcat cattcccgag gtacaggaac ggtgtccgat 5641 atttaaaact ttctttacgc tctgaggtac atatctctcc tcctctggcg ttacagccat 5701 atccaccggc tcttccaaaa cagcacctgg gtaaaatgga ataaaacgaa tatggtttac 5761 ccccagctgt tgcagctgtg caatagcctc tcgagccatg gtatctgtca tatttacaaa 5821 aagagctcgg gttccctttg gtatcatact aaggttttgc aacgtactcc accggtagga 5881 aacttcaatt cccatggtaa ggctgtctat aggaacatgg cgggccacct cttctgcgga 5941 accatatgca tctgttgaaa tcacaaataa atctgccttt ggcaacgttc ccacggcaga 6001 cccgtcactc acattgtagg atgctatctc cacatattcc ccaaacagtt cattgatttc 6061 ttttgcataa aactctccgg ctctggcatc caaagccact acagacatcg tttttttcat 6121 gattccttca tgattcctcc ataattttct catattacct acatttatta tagcttaaag 6181 aataagtgaa tgcaattttg tataaatgtc aagattagat tagaatgtaa ctttttgatc 6241 atttaagaat gtagttttgt actcataccc catgtcaata agctgtaaaa ataatttaga 6301 attataatta cttccaattt aaatattgat aattatacta cacatatacc taattagtac 6361 attcttaaat gatcattttt ttacattcct tagtataatt tataccattc cccttatatg 6421 acaaaaggat gctgcaaacg tttttataca gcatcctttt tcttctcctc tgtcaggtat 6481 ctgtatcagg cctgatatgt cttccaggtc tttttttaac cctctagagc ctttttgata 6541 tccatggtca tttcattatt ttctaaaacg aaacatggaa tccctaaact ttctgttcct 6601 ctgatttcat cgtaaagagc attagtatct cttagtttta aatattcctt taaatctgca 6661 tggcaggaca gaatatcctt aaaatcaata tctgctccaa cagcagaaag cttgtttaat 6721 gcagctaagg tatctgggca aagatgactt ccaattacag taattttcat attatttcct 6781 ccttatttta cagcgattgc ttcaatttca cataatacac ccttcggaag ggtctttact 6841 gctatacaac tgcgagctgg atttgatacg aaatattttg cataaacatc attaaaatct 6901 gcaaaatcct ccatatccgc taaaaagcag gtggttttaa atactttttc aaatctggtg 6961 cctgccgctt ctagaatggc acctacattt tcacagcttt gttttgcttg ttctgcaatt 7021 ttctctgcta tttctccatt ttctggatta accggaatct ggccggaagt ataaacaatc 7081 ccgtttactt catatccctg agagtatggt ccaatagctc cgggagcttt tgttgtttca 7141 ataattttca tgtattcttc ttcctttctt tttattttat ttttttctct gtttaacagc 7201 taatttctat tttatttatc tccccctctt tatttatctc tccctttaac agccaatcct 7261 tgccttccac aaaacgtgcg ataatcatgg aggcaatagt atcacctgac gaattgaggc 7321 aggtagctgc tgggtccacc aaaaatccga tagtggcaat taatgggaac gcttcccctg 7381 ggaacccaaa gaaactgaca atcagcattt ctcctaccaa accgccacct ggagcaccag 7441 ataatacaaa tgcacttaaa attgatacca agacagccat agcataggtt cccatccctg 7501 taaacggcat tttgaacaca ccgaacagaa aagcaatctt cgttatggac gaaattacag 7561 aaccgtccat atgcatggta gctcccatag ggagaacgat gttatagata tcctccggta 7621 ctccgatatt tttacaggct ttcatattaa cgggcaaggt agccacagag ctttgtgtgg 7681 caaatgaagt aactgcagga tccaaaatat tctgcagcat tttctttact cccagccttc 7741 ctccagcaaa atatgtataa gccgggtaga aaaccatccc ataaacaagg cacatcggat 7801 aataaatcag catcgtacgt ccataatccc caatcagctg aggaccaaat ttaccaatca 7861 gatttgcaaa ataagcgccc aatccaatag gagctaactt cataatcatt tcaacaatcc 7921 gcataatgac cctattcagg ttttctaata acttacctac agcgctttct tccccaccgc 7981 aggcagatac agccagaccg gaaatgatgg caaatacaat aattggcagc atgttcttac 8041 ggctcataag accggaaaaa tcgtcaaccg tcaaagagcc tacaatcata gagctgatac 8101 ttgcactctc ctgcaccttt gcgctttcca ttgcaattgc agtattcgct gccggcgacc 8161 agatattgac aactaccaga accagcactg ccgcgaaaca tccggttacc acaaaggtca 8221 acatcagact ccccaaaatt ttacccaaac gtttcatgtt cagcatactg cccacagcag 8281 ttgctattga aacaaatacc atcggaacta cgatagtaaa cattaaatta ataaaaatat 8341 ttcctaaagg ctcaaatact gttgcctttt ctcccaaaac aacacccaat atagctccag 8401 caataatccc cccaagcaaa atgagtggag atcgataact ctcccatatt ttcttcttcc 8461 ccatattttc tcctttccag catttcataa aaaccccagc ttttgtattt tataatttat 8521 cgattgcttc ttttaactgt ttcaatgcct gttccagtac agagcgcggg catgctgcat 8581 taagtctcat gtatccggaa aggctgcgtc caaaactaca tccttcattt aagcctaaac 8641 caaccttatg aatcatgaag tcacggagct cttcattgct catgcctaat tctcggcagt 8701 ccagccagac cagatatgta gcatctggaa cattaggctt gatttttgga atgttttcat 8761 caaaatattt tttaataaaa tcaaagtttt ctgagacgta agcaagtagc tgtgtcagcc 8821 actcctcgcc ttcattgtaa gctgcttcca tggccactga gctaaaggca ttgtttcttt 8881 gaatatccat attcatccag aaaccatcga acttctgctt catctgttca tttggaaaga 8941 tagtcgtaga agcttgaaga cctgctaggt tgaaagtttt agttgcagat acacaggtaa 9001 taattttttt tgaaatttct ttggaaagtg ttgctgtagg catatgcttc tttccatgga 9061 aaattaaatc tgagtgtatc tcatctgaca ccagaagcac atcatttgca atgcatattt 9121 ccgccatccg ttttaattcc tccggctccc atacaatgcc cagtggattg tggggattac 9181 atagaagaaa aatcttacac tcttttgcct ttttttcaaa atcctcaaaa tcaatatgcc 9241 actttccatt tttttctatg aactggtttt ctaccactac tcgtgcccaa gcctctgtga 9301 tatcataaaa ctctgaataa accggagtct gaatcaaaat tttgtcgcca gtgtggctga 9361 aaattttcac aatagccgat aatgcaggaa caacccctaa gctccagctc atcagggata 9421 catcaacatc ccattgattc cgcctttttt cccattcctg tacggcctta aagtagctgt 9481 ccggcctgga agtataaccc cagacgcctt cctcggcttt tcttttgcaa gcatcgatga 9541 ttggttgagc agttctgaaa tccatatccg caatccacaa aggaatcact tcactggtac 9601 cgaatttttt cacccgttca tcatactttg ctgcacgatt attgctgcgg tcaatgattt 9661 catcaaaatc atatttcata ataaatcttc ctttcctcac tgttcttgtt gtttacagtt 9721 gatactaata taatgagcaa aaaccatgcc aaaaattttt tttgcatttt taaacaaaat 9781 ttgtgttttc ccaccttctc agcttatctt aattggtcta tttggtcata tatatggtta 9841 atatgtttca tatgaccatt ttaaccatat tttgtactta ttttatcttt cttttctatt 9901 ataatcccct tatttttctc ttattcaaaa attggcatat tttttgctct atataaaaag 9961 taaaaaccaa accctgaaag gagatttttc taatgctaac aaaagaaaat ttattagcct 10021 tattaaagca ggaggttgtt cctgctctcg gatgtaccga acctgtctgt gtagccctgg 10081 ctacggcaga cgcctatcat gccataggag gcagaattgt ttctattaaa atagaagtaa 10141 atcctggtat ctataaaaat ggaatgtctg taggcatccc cggcttcgac cgcgtaggcc 10201 ttaaatatgc ggcctcacta ggagcagtca taggaaatcc tgagaagaag ctagagcttt 10261 tagaggatat cacagcagag gtaagccaaa aagccataaa aattgtagaa aacagccagg 10321 ttgtagtagt aattaagcat gaagaagctc agttatacgt acgggcggaa atcatcacca 10381 ctgctggaat gggcatcagc gaaattcgtg gcacccattc caatatcatt tttaccaaac 10441 gaaataatga tatgcttctg cagaaggaat actctgtcga ctctgacgat tcccttcatc 10501 agcagctgaa gcttatgggc atagctgaaa tccgtaagtt gattgacgag tgcaaggaag 10561 aagagctgtc cttcctatta gacggcgttg atatgaatga aaggctagca gactatggtc 10621 tggagcattc tcttggaatc ggcatcgctt ctgccctgca ggaaaaaatg accacagata 10681 ttatgggaga taatttattc agccgaacta tgctccgcgt tgctagtagc gccgaaggtc 10741 gtatgagcgg ctgtccctac gccgtcatga gcagtgccgg cagcggcaat cacgggatca 10801 cagctattct gcccgtaaca gaaatggccc gttacttaaa ttcctccaga gagcagctgg 10861 taaaagcact ggcattttca cacactctga acgtttatat caagcttttt acaggcaaac 10921 tgtctgccac ctgcggctgt ggcgtatccg ctgctacagc agcctcagca gctatggtat 10981 ggctaatggg tgggaatgaa caccagattg ccaatgccat tatcaacatg agtggaaatt 11041 taactggtat gatttgtgac ggcggcaaaa tcggctgtgc cttaaaactg gctaccgcaa 11101 caaatgcagc attaatgtgc gcttatctgg ctatgtctga cgtagcgcta cagccatcag 11161 acggaatctg cgatgtaaca gcggaacaag ttatccgaaa catgggacaa gtcagcaatc 11221 ctggcatggt tgaaacagac caaaccattc tctctatcat gatagagaaa gaccagagga 11281 agtaaactgt gccctgtaag atagacacag aaaagaggct gtgttaactt acagggtacc 11341 ttttttcttc caatttaagc ctaaattttt attaagtaat ctattaaatc ctaattataa 11401 ggataatctt tcttatactt tatatagtat aattcacgat tttaaaatag cttaatcatt 11461 aaaattatct attatttatt ataaatagaa aaaagatatt taaatggttt atttttatat 11521 ttaatataaa tttatataaa atcatacttt ttatgtaaag tcttaaacaa taattgcgat 11581 aataaacaga aaaagtaaat tttgaaaaaa agggggtgaa aaaagtgaaa aagaggaaga 11641 tttctataat aatagtttgt ctaattataa ttacatctat aactctaatt tataaccata 11701 ataagactaa gaaaactcaa actgatagca atatacaaaa ggttcaatcc aaaaaaaatt 11761 catctggaac caatataaag aataataaca attctaaaaa taattctaaa aaaaaggaaa 11821 cttcagagaa agaaacaaat cagaattcaa aaatcaataa agatgaaata tctagtgtta 11881 ttaaaaataa tgatgccaaa aacttagata atgtgaaaaa tttagataaa atatcctcat 11941 tagaaattat tgatagtggt atagaacata tagataaatt aaaaggaaaa gaaaatatta 12001 aagctttaaa aatagttcac tgcaatataa aagatttaga aattatatct acattaaaaa 12061 atctcgaaaa cttagaaatt atagattgta atttaaatga tgtatcaata gttaaaaact 12121 taaaacaatt aaaaagatta gatattagca ataatcaagt aagtaattta gaaggaatag 12181 gaaacttaac aaatttaaaa gagctttata tgtcaaacaa taatataaca aatatagagc 12241 caatgtataa attgcttaag ctaactaatt tagatattag tgataataaa attaataaca 12301 ttaaagaatt aaaaaatatg aaatctatta aagaacttaa tatttgtaac aacaatgtat 12361 ctagtttaga aggaatagaa aatatggaac atctggtagg tctttggacc agtagcaata 12421 aaataaataa tatttctata ctttcaaata aaaatcaaat agtgaactta tcattagata 12481 acaacaaaat atcagatata tcagttataa gtaatcttaa aaaattgaaa tctctaaaac 12541 tagataaaaa taatatatcc aattataaac cattaaaagg tatatataaa aatctagttg 12601 aaccagattt ttcaatataa aataaaaagg gggaaaaata atgaaaaaaa atcttttacc 12661 aaaactggtc ttaccaattt tagttgcatc atctactatt ataggagcaa atcaaaccaa 12721 ggttagtgct gcgcctataa aggatgcaga agtaaaatta actcaacctg atggacaagt 12781 tgttcaatgt tacgcctcag gagatgaatt ctataactat ttacatgatt caaatggaag 12841 agctatagtt aaggatgaaa aaacgggata ttatgtctat ggaaaatatg taaaaaataa 12901 agtacaacca tctagagaaa gagtaacaaa gagcaatatt gaaactttaa aacaaattga 12961 tgctgatagc aaagttaaca tgaaagatgt taaagctcca aaaaatgaaa ttgaaaaaca 13021 aagagaattt cttaatgcaa ataacccaat ccaaaggaca aaaaatattg gacaacttaa 13081 taatatagtt atttttataa aatttagcga tcaagatgaa ataacaagag atttttctac 13141 ctataataaa caatttaatt caaaaaacca ggcatcttta aataattatt acaaagaagt 13201 atcctataac aaactagatg ttaatacaac tttctatcct aaacctaatg gagataaagt 13261 tttaagctat actgacagtc acccaagaag ttattatact aatgttccac aaaatgaaag 13321 agcagcaaga gagcaaacct tacttaaaaa tgctgttgat tctgttaaaa gtgaaatccc 13381 aagtgattta aatgtagact cagataatga cggcaaagtt gataatgtgt gttttattgt 13441 aaagggagca acaactggat ggtcatcact tttatggcct cataaatgga atatgttcta 13501 tcaagatgta agaataaatg gtaaaaaaat agatacttat aatttccaat tggaagattt 13561 tataggtgat aatggtattg gagttctaag tcatgaaatg ttccatacct taggagcacc 13621 agatctttat cactataatt atgatggcaa agttgctgta ggaccatggg atgtaatgga 13681 tcagactgca tctattcctc aatccatggg gacatacatg aaaatgtatt acggtaaatg 13741 gcttaataac ataaatgaaa taaataaacc aggaaaatat tcaataaaca aaataggcac 13801 tgaagctaat aacagttata ttataaagtc accaaattca aataaagaat attttgtagt 13861 agaatacaga aaaaatgaag gacaatatga atcaaattta cctggagaag ggttattagt 13921 ttatagaatt aatacagcat ttcaaggtag aggtaattct agtggtaatg atgaagtata 13981 tttatacaga caaaatggaa gtttaaataa tgtcggagat atatctagag cagctttagc 14041 ttataataaa acaagtataa attcaaagga attattctta tcagatggaa gtgatagtgg 14101 aataagttta gaaaatatta atgtattagg taacactgct aactttaatg ttgttataaa 14161 cggacaaact gctgatagta aaactgttga taaaaactta ccacttaaac accaagtgaa 14221 ttttgatgat actaaaacat tatcaaacac tgaaaatata attggtgaat gtgtatatgg 14281 aaagaaaatt aataatatag aattatatat aaatggatat aaatatatgg atgctgaacg 14341 tagcaaatta aatgatccag gaaataaata taaaggttat gacttatcta aagctgcatt 14401 caaattttca atggactttt caagatggta tgaatctaat tatccatacg aaataaaggt 14461 aactacagaa gatggacaaa ggatttcaat taaaaaaggt tatttaagag taaaaaaaca 14521 ggaaaacagc aagaatttag ctttcaaagg taatttcaac ttaggaaata atgaagcttt 14581 atatggcgct agaactttaa ctggtgaatg cgtttatgga aaaggaatta aggcagttaa 14641 attatatgtc aacggatatc catatgttga tgcaaaaaga tatgcaataa acgatccaca 14701 aaataaatat accggatatg acttatcaaa ggcaggattt aaatttgatt tatatttctc 14761 aaattggcat aattatgatt atccttacaa agtagtagca atagactctg aaggaaatga 14821 aatgttaatt aaagaaggtc atttaaaggt tagaaattag tattaaaaat taaaatactt 14881 taaacgctgc gttaagcata tgtaagtagg taaatttgtt cttacacaaa tttacctaca 14941 ttttttatag cataaacaaa taaattttga gtgactataa ataagtcttt gctatatcta 15001 taaacctttt taattacttc gaaattattg aacttttata cttaataatc attagttctt 15061 ttaactatac ttttttaggc aaagtttaaa ttccactcct ttttcattgt ttgaaataga 15121 atattttcca ttgtgtgcat ctaaaatcat ttttactata taaagtccaa gtccactacc 15181 tccacttttc ctattacgag atttttcaat tctataaaaa ggcttaaata tttctttaag 15241 ttcattttct tctatatagg ttcctgtatt ttccaccttc aatacaattt catctttttc 15301 ttcatgaaga tttgcataaa ctttttcact ttctggagaa tgattaatag cattagttat 15361 tatattgttc actactttct ttaataattt actatctccg tgaacaaata aatcttcgtt 15421 tatattttta tctatgaata tattctttct tttagctata aaggagatat tatatataca 15481 ttcttcaact attttactta aggaaatctg ctcttttcga ggtttaaagc cctgcgactc 15541 taattttgat atttctaaag tttccttaac catatattcc atatcattta aaacttcaag 15601 atttctcttt aaatatttat ccctgtcttt ataaatacct atattagata gcattccttc 15661 tatttgcccc tttaaaatag ttataggggt ttttaattca tgagatatgg tggctataaa 15721 ttctcttctt tttttctcta tttccctctc tttagcaata tcatctaata attgttcatt 15781 agctctttgg agttcctcca tagagatcct tagattattg gacagatcat ttaaactttg 15841 agaaagttct cctatttcat cctccccttt tacggtacac ttcttagtaa aatctaattt 15901 agccatttct ttagctactt tattcatgct tattaacggc ttagatataa ctttagaata 15961 aattaatccc cctattacag aaattaaaat tacaactaat cctatgtaag gtataagtaa 16021 aaataaaact ttagatgcct ctgacacagg ctgaagcgga gcagttaaat ataaattata 16081 cttttcttca ctattataga attttatttt tctataactt gtatacactg atctagtatt 16141 agttttttct atatttttaa aatgagataa atcttctttt ttaggaatag ttacaagacc 16201 tttttgaaga acattagtaa aataaataac gtttccatat tcgtctgtta ctactatatt 16261 ggcattatta ttaaatgaaa tttgccccaa atattcttca atattattta tatctaattt 16321 aggtacatta tctactatac tatctaattg attttctata gtcatttttt tatatttatg 16381 ataataatta ggtagcagca tataaattat agagtaagtg catatagaac ttattactaa 16441 taataatgta gttactaaaa atagcttata tactatactt ttttttaatt tatttctcaa 16501 ttttataccc cactcccctt atggtcttta tataatctat gtttagtttt tgtcttaaat 16561 ttttgatatg agtatctata acacgggtat ctccaaaata atcatatccc catatttgat 16621 ttaataaaga ttctctagaa aagacccttc ctacatttga tattaatatt tctaatatct 16681 gaaattcttt ataagttagt tctatttcct tattattaac taaagtttta taattagaag 16741 gatatattgt tatttcttca aaggttaaag ttgaattatt ttcctctaat ccattggctc 16801 ttctaagtac tgcttctact ctttttatta ataaattaat agaaaagggt tttgttatat 16861 aatcatctac ttttaattca aaacctttca tctcatcctc ctcttctcct agagcagtaa 16921 gcattattat aggcatactt gattcttttc ttataatttc acatactaca aatccatcta 16981 ttttaggaag catcacatct aaaattatta aatcaaaatt cccccttcta aacatctcca 17041 ccgcaattaa tccatctgta gccacctcca ctaaatatcc actttccttt agaacctcac 17101 ttataatagt atgtatatca aaatcgtcct ctactacaag aattctcttt ggcattgtaa 17161 tccatctcct gtttaaatat atcattatat acataattat tttttaaata aaaataaatt 17221 cctttatatt ttatactaat aaatacttta aatccatgaa catattttta ataattatta 17281 tatatcatta atttcaaacg aaaaaagtgg ctatctcaaa ataaaaatag ctttaatttt 17341 aaaaccgtaa atataaataa tatattcata aagcacttca ttttgctaag gagttctaaa 17401 tttgactcca ttaaaaattt tttacccagt agaggcacca tccttggttt cactactggc 17461 tcatcacgtc ctgtgaggaa ttacaaaaat ttttaattcc gtcaaattaa gaactactaa 17521 aacttattca tatgcttatt acatatatta tttatatcta ctatattaaa attaaagcta 17581 ttttgagatg ctctttttat ctatatctta gctacctaag ttttgtttgt acaaaactta 17641 ggtagctagc aattttaata ttctaaattt atttccttat tctttttagc aaatctttgc 17701 tttatctcat cttttctacg cttaatatct gtagtattta tggtagctat tactccttct 17761 accacacttt gaaatctttc aaaagggatt cctattgcca tttcttcgtc cttccatttt 17821 gctaaaaatc tagtgcttgg acaaagaact gtggtattta gtctaccttt tatataaggc 17881 tctacagtgg cttctgcaca aattgcttgc attgaagcgc ctgtgatttc caatcttcca 17941 ccttcatgat atacatatcc ttgctgaatt ctcatagctt gataaggatt tacgataaaa 18001 ataaccacat ctggagtagt ttcaaattct tctaaaggtc ccactgccac tccatatgta 18061 gtggctcctg tcctatataa tccgggtaca ccttccctta cccttctcgc tgcagctggt 18121 gttttatata aattgtaaga aaaatattct gcaccggact ctattctttc tgtggaaggt 18181 tctaaattta gggcagtagt acctccatca caacttaaat gttcaagtct tattttaaat 18241 gctttccctc tagtagcttt ttctactaca cagcaataag ataacggtgc attaggttcc 18301 ttccattcta atttactata ttcttctttg tcaaaatata attttatacc tacaggtttt 18361 ctactaaaat ttaatgcaca gttaatatct tcacataatt ctttaataat actattatca 18421 tatgggtcct gtggaaatcc ataagtaatt ttttcatgtt taaacggcat //