LOCUS NC_006347:25 18209 bp DNA linear BCT 18-AUG-2011 DEFINITION Bacteroides fragilis YCH46, complete genome. ACCESSION NC_006347 SOURCE Bacteroides fragilis YCH46, complete genome. COMMENT locus start: 3638165; locus end: 3656373 FEATURES Location/Qualifiers source 1..18209 /organism="Bacteroides fragilis YCH46, complete genome." gene 0..935 /gene="" /locus_tag="" /db_xref="3638165..3639100" CDS 0..935 /gene="" /locus_tag="" /product="putative serum resistance protein BrkB" /translation="MEIHSERKKRLSLSLLFKIIKDTVWGFIDDSVMRLSASLAYATL FSIIPFLSLLVTVGVFFHMDLANQLYVQLQPIVGPEVTEALRSIIENAENTDSSRSAA FVSLGISILGATTIFAEIQSSLNSIWGIKAVPKKSWLKFIKNRILSFSIILVFAFILL ITFTITNIIGELSQKFIFKYPEAADSLVKVVGIIINMSVTTIIFTLIFKILPDAKIKS KDVCIGAVVTTILLLIGQWGISFYIGIANVGTVYGAAAFMVVFVTWIYYSSIIIYTGA EFTKAWANEMGGKIFPDEYAVATKTIEIHEDKPIE" gene complement(949..1350) /gene="" /locus_tag="" /db_xref="3639114..3639515" CDS complement(949..1350) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MEILSPELLYSIIVLNKRLRYSYLNIIMLTFTDNFENDKELILR DHLALERTKLANERTLFAYIRMALYLLTVGIGIFQIESISRLDGLAWGCIIAGIFLFF LGFVRFEQMRKHLKQYTKTCRDTENESSRKK" gene complement(1638..2474) /gene="" /locus_tag="" /db_xref="3639803..3640639" CDS complement(1638..2474) /gene="" /locus_tag="" /product="putative ferredoxin" /translation="MTANEVHLIYFSPTHTSKQVGEAIVRGTGITNVINTNLTQQATQ DLVIAESALAIIVVPVYGGRVAPLAMDRLASVRGSNTPAVIVVVYGNRAYEKSLMELD YWAIQQGFKVIAGATFIGEHSYSTEKYPVAAGRPDERDLAVAADFGKQISDKIASATE PEKLYAVDVRKIRRPRQPFFPLFRFLRKVIALRKSGVPLPRTPWVEDESLCTHCGACA KMCPVSAIAKGDELNTDAERCIKCCACVKGCPQKARVYDTPFAVLLSQCFVKQKDPCT LV" gene 2749..4812 /gene="rho" /locus_tag="rho" /db_xref="3640914..3642977" CDS 2749..4812 /gene="rho" /locus_tag="rho" /product="transcription termination factor Rho" /translation="MYNIIQLNDKNLSELQAIAQELGIKKTDSLKKEELVYKILDEQA IAGATKKVAADKLKEERKEDKKKRSRVTVKKENADKVFSSTKNGELTKTDAKTPAAKT QPQPKTTEPTPETAKEANAETNATPAESVKVTPYATPKKKPGRPRKNQVETEAKPAEE TTEKPETVPSAQEEKPAAQPEAEKRPISKPILKPKPAVVDEESSILSDIDADDDFIPI EDLPSEKVELPTELFGKFESTKAEAATAPEPVAQPQRPRVIRPRDNNNNNNNNNNNNQ RNNNQRQPVQQRPMPQQNAAEAAPVQERRVIEREKPYEFDDILTGTGVLEIMQDGYGF LRSSDYNYLSSPDDIYVSQSQIKLFGLKTGDVVEGVIRPPKEGEKYFPLVKVSKINGR DAAFVRDRVPFDHLTPLFPDEKFKLCKGGYSDSMSARVVDLFSPIGKGQRALIVAQPK TGKTILMKEIANAIAANHPEVYMIMLLIDERPEEVTDMARSVNAEVIASTFDEPAERH VKIAGIVLEKAKRLVECGHDVVIFLDSITRLARAYNTVSPASGKVLSGGVDANALHKP KRFFGAARNIENGGSLTIIATALIDTGSKMDEVIFEEFKGTGNMELQLDRNLSNKRIF PAVNIVASSTRRDDLLLDKQTLDRMWILRKYLSDMNPIEAMDFVKDRLEKTKDNDEFL MSMNS" gene 4944..6794 /gene="" /locus_tag="" /db_xref="3643109..3644959" CDS 4944..6794 /gene="" /locus_tag="" /product="putative two-component system sensor histidine kinase" /translation="VGRSFNIALIVIAVTLYSVTTYAADNKATRHVSALLNLIDNSLN YSKEAPNDSIIQWGNELAPLLKKQKEYKTLFQLKQLIVTAYASRGDMNMAIDHARRMY KEAKELNSPIGIALSSRAIGDAYLNANMQQPAIESYKEALELLDKIPGSEILEQEILP KFILTLIQTSHMDEVRIYLQKFENLYADNPNPTFHFFICACNAYYDIESGDPEKGKAE LDKAGKIHEQMKSLYLRSIYNYILAQYYQAVGKYELALQQYECLTKVPKAPAPNKHIG LQLECAQLLTQMGRTEEAYRIYQKANRQKDSLNALSYARQINDLRGMYQIDRMEIRNQ IQRNQIILWIIIASIFILMLVLLLIVRIRQESNRLLRSKEELEIARKYAENSIRTKSL FLSNMSHEIRTPLNALSGFSSILTDESIDNDTRYQCNDIIQQNSELLLKLINDVIDLS NLDPGKLTFNFKECDAVNICRNVINTVEKVKQTQAGVSFVTSLDKLALRTDEARLQQV LINLLINATKFTTEGSITLTLEKESETMALFTVTDTGCGILREKQDQIFNRFEKLNEG AQGTGLGLSICQLIIEQIGGRIWIDPDYTEGARFRFTHPVRPAKEKEAER" gene 6791..8746 /gene="" /locus_tag="" /db_xref="3644956..3646911" CDS 6791..8746 /gene="" /locus_tag="" /product="putative two-component system sensor histidine kinase" /translation="MKRLILIIIVCCRALGWCHANTQTETDSLYRVAQSLPHDSTRLE MFKRLAQIEQLTPRCITFSGLLREEATLQKNDRYNAIAAYLHTVYYYNQNNRDSVKKW LDTMEPYARKSQTWDLYFDALRFQIDLCTYEEQYELAINEANLMYERAQKVNCARGLI GAKQCLGNVYISTERWDEGMKALEAAYQLSLQTDNAVVRISILCQLISITKDQKNNQL LSEYLAKLKETLHHHTSTNPMLKEAFYDVYLFCEVYYTYYYLYAGQPEQAHKNLVNAG KFLNGNTFFLYRVLYYDAYAAYFRACKAYDRALAKIDSTIILLQEDFNSNYIHQKLTK ADLLAEAGRSAEAIPLYIETLHLKDSIETTVLDKQMQQIKAKYNIDKVALEEERLKSY IQLGTLIVVVIILIILVAFMLRISHVRKALERSEKETRETTRMAEEANEMKNRFLSNI SYHIRIPLNGVVGFSQLIASEPNMPDELRKEYSSIIQKNSEELMRLVNDVLDLSRLEA GMMKFNIQEYGLAELCNEATYMARMHSEGCTVIRLENEIDTDLNIRVDTVRFTQALLS ALTYPQKYKEKREIDFKVTLDTEKNFINFRITNSPLADERFTSQEVCIRHEINRLLFE YFGGSYKVQTNPDGKPTILFTFPSGRN" gene 8821..10143 /gene="" /locus_tag="" /db_xref="3646986..3648308" CDS 8821..10143 /gene="" /locus_tag="" /product="multidrug efflux pump BexA" /translation="MYTNKQIWSVSYPILLSLLAQNVINVTDTAFLGRVSEIALGASA MGGLFYICIFTIAFGFSTGSQIVIARRNGEARYGDVGPVMIQGVLFLLVMALLLFGFT KAFGGNIMRLLVSSESIYDATMEFLDWRIFGFFFSFVNVMFRALYIGITRTKVLTINA VVMALTNVVLDYALIFGHFGLPEMGIKGAAIASVIAEAASLLFFLIYTYITVDLKKYG LNRLRSFDPVLLMRILSISCFTMLQYFLSMATWFVFFVAVERLGQRELAIANIVRSIY IVMLIPVNALATTTNSLVSNAIGAGGINYVMPLINKIGRFSFLIMLGLVIITALFPQA LLSVYTNETALINESVSSVYVICVAMLIASVANIVFNGISGTGNTQAALMLEAITIAI YGSYIIFIGMWVKAPIEWYFTIEILYYTLLLATSYIYFKKAKWQNKKI" gene 10295..11614 /gene="" /locus_tag="" /db_xref="3648460..3649779" CDS 10295..11614 /gene="" /locus_tag="" /product="putative signal recognition protein" /translation="MFDNLSERLERSFKILKGEGKITEINVAETLKDVRKALLDADVN YKVAKGFTDTVKEKALGQNVLTAVKPSQLMVKIVHDELTQLMGGETVEIDTKGQPAVI LMSGLQGSGKTTFSGKLARMLKTKKNKRPLLVACDVYRPAAIEQLRVLAEQIDVPMYS EIDSKDPVSIAQNAIKEARAKGYDLVIVDTAGRLAVDEQMMNEIAAIKEAIQPNEILF VVDSMTGQDAVNTAKEFNERLDFDGVVLTKLDGDTRGGAALSIRSVVNKPIKFVGTGE KLDAIDQFHPARMADRILGMGDIVSLVERAQEQYDEEEAKRLQKKIAKNQFDFNDFLS QISQIKKMGNLKELASMIPGVGKAIKDIDIDDNAFKSIEAIIYSMTPEERSNPGILNG SRRTRIAKGSGTTIQEVNRLLKQFDQTRKMMKMVTSSKMGKMMPKMK" gene 12019..13104 /gene="" /locus_tag="" /db_xref="3650184..3651269" CDS 12019..13104 /gene="" /locus_tag="" /product="thiol:disulfide interchange protein" /translation="MKHILFTLALASIAGIANAQHNGHSYTVEGLINDSTLNGQTLYI SRYDDGMKVDSTQVTNGQFKFTGKADIPCFCRIDAGREYANFILEGGNIQVNVLTHND PKGTPMNEEYTHISDKTSELVTELRKRHAAIEQQTEDKSEQLRLKKEYADTYWHPTYT RLYKDMFMKNPDNALGEFAIRELAMCALPEEMDTIFAASGPWLKSLSVYHRIEKQFQG MKATAVGQKFTDFSGKTIDGTASSLSDFVGKGQYTLVDFWASWCGPCRSESPHIAELY NTYKDKGLTVLGVAVWDKPENTKKAIKELNIDWPQIIDTGMTPMDLYGVKGIPFILLF GPDGTIIARDLRGEGMKNKVAEVLNNK" gene 13124..14005 /gene="" /locus_tag="" /db_xref="3651289..3652170" CDS 13124..14005 /gene="" /locus_tag="" /product="methylenetetrahydrofolate dehydrogenase" /translation="MTLIDGKAISEQVKQEIAAEVAEIVAHGGKRPHLAAILVGHDGG SETYVAAKVKACEVCGFKSSLIRYESDVTEDELLAKVRELNEDDDVDGFIVQLPLPKH ISEQKVIETIDYRKDVDGFHPINVGRMSIGLPCYVSATPNGILELLKRYRIETSGKKC VVLGRSNIVGKPMAALMMQKAYPGDATVTVCHSRSKDLVKECREADIIIAALGQPNFV KAEMVKEGAVVIDVGTTRVPDASKKSGFKLTGDVKFDEVSPKCSFITPVPGGVGPMTI VSLMKNTLLAGKKAIYQ" gene 14073..15704 /gene="" /locus_tag="" /db_xref="3652238..3653869" CDS 14073..15704 /gene="" /locus_tag="" /product="probable thiol:disulfide interchange protein" /translation="MNTIFKTTGLCVFLFTCTPWATAQNFSIDYPSYQKRNTDALEIS RIVRNDTATILYMDAYSRPNYWIRLASELSLHGVQSGKKYPVIRSQGFELDKQVYMPA SGNVTFTLQFAPIDPQDRTIDFVESNNEEDFRIEGICLDASVPKKKVHCHLAGKMANR PQTSRLILIESNKNTRGTPWISIPVRNGVFEYDFYTDHEKAYELICWDDLLNGCWYPV TFFAENGTVSFTISAIDARPPYRIETLNPLTTALRLFEAEGEDKFSFDELNARRDTLE KYGRFESEAMQALWKKFDQVKDNPEERNKLFRERDRLEESGEAFTEEAKALIKEREQL FRKKVIWETEQASQHPSLVGLFILKMKVENARKDEDVIPYLEVFQKVYASRYPEHPYT REMQMFIDNNQPKTGNRFIDFSAPDLNGNMVQLSEQIRGKVALIDLWASWCGPCRTTS KQLIPIYEKYKDRGFTVIGVAREQNSDIRMREAIRKDGYPWLNLIELNDVQQIWSKYR IPNAAGGTFLVNAQGIILAVNPTAEEVERILQKEL" gene 15717..16835 /gene="" /locus_tag="" /db_xref="3653882..3655000" CDS 15717..16835 /gene="" /locus_tag="" /product="capsule biosynthesis protein" /translation="MKHLILLFLFFCSVSCSSNAQEQPVPTSSADTIPAQKITLLFAG DLMQHQAQIDAARTATGYDYTDYFKLIKEEIGKADIAIGNLEVTLGGKPYRGYPAFSA PDEYLTAIKDAGFNVLITANNHCLDRGKKGLERTILMLDSLQIPYAGTYTDSTARASR YPLLLEQNGFRIVLLNYTYGTNGIKVSAPNIVNYIDKDIMARDIETAKALNPDALIAC MHWGIEYQSLPNKEQTSLADWLLSRGVTHVIGSHPHVVQPMELRTDTLSGQQNVVLYS LGNFISNMSTRKTDGGLLFKLELTKNSIGTSVSNCGYSLIWTARPTLSKKKNYVLYPA SIPTDSLSAEERNRLKIFINDTRELFRKHNRGINEYIF" gene 16915..16990 /gene="" /locus_tag="" /db_xref="3655080..3655155" CDS 16915..16990 /gene="" /locus_tag="" /product="tRNA-His" /translation="VAVVQLVRASDCGSECRGFESHLPP" gene complement(17180..18208) /gene="" /locus_tag="" /db_xref="3655345..3656373" CDS complement(17180..18208) /gene="" /locus_tag="" /product="hypothetical protein" /translation="MIRFSKMFFYVTVAVLLVWQLPWCYAFLTLKPAKTPFTMYSSVL GDFVITQLDENKQLHRYDTKGNTYTQQQVDSLLPSLYVRQLTADERFPDTICGRAVSP KDIQLTNFTFKSVPSAINAPQTGLYFLMESMSKRVDLKMPEDAFRFTDKGIEFIRMET NRIDEAKSELFTEMLVQKGFAFPASYASGNPTTRKDYDEGYLVLDANHKLFHLKCTKG RPYVKLIQLPEGVLPEYVFITEFRSRRTLGYMVDSQHHFYVINSDGNLVKSALPGFDP TKDELTIFGNMFDWTVKLSTDKDDYYYALDATDYSLIKEYAYKDMRRSVPGLSFTSPD DKFVMPRF" ORIGIN 1 atggaaatcc attccgaaag aaagaaaaga cttagtttat ccctgctctt caaaataata 61 aaagatacag tttggggatt catagacgac agcgttatga ggttgagcgc ttcattagcc 121 tatgcgactt tgttttcaat tattcctttt ctttcccttc tagtcactgt cggtgtcttt 181 ttccatatgg atttggccaa tcaactttat gtccaactac aaccgattgt gggccctgaa 241 gttaccgagg cccttcgttc tattatagaa aatgcagaaa atacagactc ctccaggtcg 301 gccgcctttg tcagcttagg tatctctatt ttgggtgcca ccactatttt tgcagaaata 361 caaagttcat taaattcaat ttggggaata aaagccgtcc ctaaaaagag ctggcttaaa 421 tttattaaaa accggatact ttctttctca ataatacttg tatttgcctt cattctcctg 481 attacattca ccattaccaa tataatcgga gaactcagtc aaaaattcat ctttaagtat 541 ccggaagcag ccgattcgtt ggtaaaagtg gtaggaatca tcataaatat gagtgtcact 601 accatcatct ttacactcat atttaaaata ttacccgatg ccaaaatcaa aagcaaagac 661 gtttgcatcg gagctgttgt aaccaccata ctgctactga taggtcaatg gggaatttcc 721 ttttatatag gaatagccaa tgtgggaacc gtctatgggg ctgctgcgtt catggtggtt 781 ttcgtcactt ggatttatta ttcttccatc atcatatata ccggtgcaga gtttaccaaa 841 gcatgggcaa acgaaatggg aggtaaaatt ttccccgacg aatatgcagt agccaccaaa 901 accattgaaa tacacgaaga caagcctatc gaataatcta gaataaaaat cacttcttcc 961 gtgacgattc attctcagta tcacgacatg ttttcgtata ctgtttcaga tgctttctca 1021 tttgttcgaa acggacaaag cccaagaaaa acaagaagat tccggctata atacatcccc 1081 acgccagccc atccaaacgt gaaatgcttt caatttgaaa tatccctatc cccacagtca 1141 aaaggtaaag tgccatacgg atatatgcaa acaaagttct ttcattagcc agcttggttc 1201 tttcaagtgc cagatgatca cgaagtatca actctttatc attctcaaag ttatcggtaa 1261 atgtcagcat aattatatta aggtaactgt atcttaaacg tttatttaaa acaataattg 1321 agtacaatag ttcaggagac agaatctcca tttatcaaat gacactgaca gaccccccaa 1381 tcctgaccaa tttaccgtac actaaaatca tttttagtta tacttttcac aactggctaa 1441 ttaaatttat gtaagtagaa aaatctcttc ataaaaaata attcttggga tacaaataac 1501 aagttattaa aatacaaaag acttgttatt tgcacacaag aatcaaatta taaggaaatg 1561 acgttaacaa tgttaattga aacaaactcc aataacaagt aaaatcttgc acaatgctat 1621 gccactaacc ttttttcatt aaaccaacgt acagggatct ttctgcttaa caaaacattg 1681 cgacagtagt acggcaaacg gggtatcata tactctggct ttctgtgggc atccctttac 1741 acaggcacaa catttaatgc agcgttcggc atccgtattc aactcgtcac ctttggctat 1801 ggcgcttaca ggacacattt tcgcacacgc accgcagtga gtacacaaag attcatcttc 1861 cacccaagga gtacggggaa ggggaacccc acttttacgc aaggcaatca ctttccgcaa 1921 aaagcgaaac aatgggaaaa aaggctgacg cggacgccgg attttacgga catcgaccgc 1981 atataatttt tccggttcgg tagcagatgc tattttatct gaaatctgct ttccaaaatc 2041 ggctgccaca gcaaggtcac gttcgtcagg acgtccggca gctacgggat atttttctgt 2101 actataagag tgttctccta tgaaagtagc accggcaatt actttaaacc cctgttgaat 2161 agcccaataa tcaagttcca tcaacgattt ttcgtaagca cgattaccgt ataccaccac 2221 gataaccgcc ggagtattac ttccgcgcac acttgccaga cgatccatgg ccaaaggggc 2281 tacacgacct ccatataccg gcacgacaat aatagctaat gcagattcgg caatcactaa 2341 atcctgagtt gcctgttgtg ttaaattcgt gtttatcaca tttgttattc cggttccacg 2401 aacaattgcc tccccaactt gtttagaggt gtgggtaggc gagaaataaa tcaaatggac 2461 ttcgtttgct gtcataatag ttacttttta tgcaacaaag gtacactttt atgaagaaaa 2521 aaagagtaaa cgaagacaaa aaccaaaatt atttattatc tttgcggcgt tgaaacattc 2581 cgaacccctc caacgggaga caaattcgga tttccgattc agccaaacat ccctaattca 2641 tcatttaaag attattgcgt ttgttaagtt tccgacccct gcgtcgcagc ttcagccgta 2701 cgtatttcaa cgaataaaat taaaatattt aaataactca ctatactgta tgtataacat 2761 cattcaattg aacgacaaga atttgtcgga actacaagct attgcccagg aattgggtat 2821 caaaaaaaca gactcactta agaaagaaga acttgtctac aaaatcctcg acgaacaagc 2881 catagccgga gctactaaaa aggtagctgc cgacaaactg aaagaggaac gcaaagaaga 2941 taagaaaaaa cgctctcggg tgacagtaaa gaaggaaaac gccgacaagg ttttctcttc 3001 taccaagaat ggagaactaa ccaaaacaga tgccaaaaca cctgcagcca aaacacagcc 3061 acaacctaaa acaacagaac cgaccccaga aacagctaaa gaggcaaatg ccgaaacaaa 3121 cgccactccg gccgaatctg tcaaagtgac accttatgcc actccgaaaa agaaaccggg 3181 acgtccccgt aaaaatcagg tagaaacaga agctaaaccc gcagaagaaa ctaccgaaaa 3241 accggaaaca gtaccatcgg cacaagaaga aaagcccgct gcccaaccgg aagcagaaaa 3301 acgtcccatc agcaaaccga ttctcaaacc caaaccggcc gttgtagacg aagaaagctc 3361 gatcctctcg gatatagatg cagacgatga ttttatcccc atcgaagacc tgccttcgga 3421 aaaagtagaa ttgccaaccg aactgttcgg caaatttgaa tcgaccaaag ccgaagcagc 3481 aacagccccc gaacctgtgg cacaacccca acgcccgcgt gtgattcgcc cacgagacaa 3541 caataacaac aacaataaca acaataataa taaccaacgc aacaataacc agcgtcagcc 3601 tgtacaacag cgtcccatgc cgcaacaaaa tgccgccgaa gccgcacccg ttcaggaacg 3661 ccgcgtgatt gaacgtgaga aaccttatga atttgatgat atcctcaccg gaaccggtgt 3721 attggaaatc atgcaggatg gttacggatt cctccgttcg tcagactata actacctctc 3781 ttcaccagac gatatctacg tttcgcaatc ccagatcaaa ctgttcggtc tgaagaccgg 3841 tgacgtagta gaaggtgtaa tccgtccgcc caaagaaggc gaaaaatact tcccactggt 3901 aaaggtttct aaaatcaacg gacgtgatgc cgctttcgta cgtgaccgtg taccgttcga 3961 ccatctcact ccgctattcc ctgacgaaaa gttcaagctt tgcaaaggag gctactccga 4021 ctcgatgtcg gcacgtgtag tcgacctctt ttcaccaatc ggtaaaggac agcgtgcctt 4081 gatcgtggct cagcccaaga ccggtaaaac catcctgatg aaagaaatcg ccaatgccat 4141 cgctgccaac catccggaag tatatatgat catgttgttg attgacgaac gtccggaaga 4201 agtaaccgac atggcccgca gtgtcaatgc ggaagtgatt gcttctacat tcgacgaacc 4261 tgccgaacgc catgtgaaaa ttgccggcat cgtactcgaa aaagctaaaa gattggtaga 4321 gtgcggacac gatgtagtga tcttcctcga ctctatcacc cgtctggcgc gcgcatacaa 4381 tactgtatct ccggcatcag gaaaggtact ctcgggtggt gtggatgcca atgcactaca 4441 caaaccgaaa cgtttcttcg gagcagcccg taacatagag aacggaggtt cgctcaccat 4501 tatcgctact gccctgatcg acaccggttc gaagatggac gaagtaatct ttgaagagtt 4561 caagggtaca ggtaacatgg agttgcagct cgaccgcaac ctaagtaaca aacgtatctt 4621 ccctgctgtc aacattgtgg catcgagcac ccgccgcgac gacttgctgc tcgacaagca 4681 aacactggac cgcatgtgga ttctacgcaa gtatctgtcg gatatgaatc ctatcgaagc 4741 aatggatttc gtaaaagaca gattggaaaa aaccaaagac aacgacgagt tcctgatgag 4801 catgaacagc taaagagttc cttttgtgaa caaaatatag taaaaagagt gagattctgt 4861 ttgattctca ctctttttat ttagctttgc actacatgca tcataaacaa gcataaaaca 4921 aacatcggga aaacaacatt tactgtggga aggtctttca atatagcgct tatagtaata 4981 gcagtaacct tatactctgt cactacatat gctgccgata acaaagcaac aaggcacgtg 5041 tcagcgctgc tgaacctgat cgacaacagc ctcaactata gcaaagaagc tcccaacgac 5101 agtattatcc aatggggcaa cgaattggct cctctcctga aaaagcagaa agaatataaa 5161 actctatttc agttgaaaca actgattgtg acagcttatg cctcacgagg agacatgaac 5221 atggccatcg accatgcccg ccggatgtat aaggaagcca aagaattgaa ctcccccatc 5281 ggtatagctc tttccagccg tgccattggg gatgcctact tgaatgccaa catgcagcaa 5341 cccgctatcg aatcttataa agaagctctg gaattgcttg acaaaatacc gggtagcgaa 5401 atcctcgaac aagagattct tccgaaattc atcctgaccc tgattcagac ctcgcacatg 5461 gacgaggtac gcatctatct gcaaaagttt gaaaacctgt atgccgataa ccctaatcct 5521 acattccact ttttcatatg tgcgtgcaat gcctactatg acatcgagtc cggtgatccc 5581 gaaaagggaa aagccgaact ggacaaagcc gggaaaatcc acgaacaaat gaaatctctc 5641 tacctgcgta gtatctacaa ctatatattg gcccagtact atcaagctgt cgggaagtat 5701 gaactggccc tgcaacaata cgaatgcctg acaaaggtcc ctaaagcacc tgcccccaac 5761 aaacacatcg gtttgcagct tgagtgtgcc caactgctga ctcaaatggg acgaacggaa 5821 gaagcctatc gtatctatca aaaggccaac cggcaaaaag actctttgaa cgctctgagc 5881 tatgcccggc aaatcaatga cctacgggga atgtaccaga tagaccggat ggaaatccgg 5941 aaccaaattc aacgaaacca aatcatcttg tggatcatca tagcttccat ctttatattg 6001 atgcttgttt tgctgttgat tgtccgcatc cggcaggagt ccaaccggct tctccgctcc 6061 aaagaagaat tggaaatagc ccgtaagtat gccgagaatt cgatacgtac caaaagtctg 6121 ttcctgtcga acatgagtca cgaaatacgg acaccactga atgcactttc cggattctca 6181 tccatcctga ccgacgaatc catcgacaat gacacacggt atcaatgcaa tgacatcatc 6241 cagcaaaact ccgaactgct gctaaagctg atcaatgatg taatagacct gtcaaacctc 6301 gatcccggca agctgacttt caattttaaa gaatgtgacg ccgtcaatat atgccgtaac 6361 gtaatcaaca ccgtagagaa ggtgaagcag acacaagccg gagtcagttt tgtcacttca 6421 ctggataaac tggctttgcg tacagacgag gcacgcctgc aacaggtatt gatcaacctg 6481 ctgatcaatg ccaccaagtt cactaccgaa ggaagcatca ccctgacatt agaaaaagaa 6541 tcggaaacca tggctctgtt cactgtgaca gataccggat gtggtatcct ccgtgaaaaa 6601 caggaccaga tattcaatcg ttttgagaaa ctgaacgaag gtgcacaggg aacaggtctg 6661 ggactctcga tttgtcaact tatcatcgag caaatcggag ggagaatatg gattgacccg 6721 gactacaccg aaggtgcgcg attccggttt acacaccccg tccggcccgc aaaggaaaag 6781 gaggcagaaa gatgaagcga ctgatactta tcatcatagt atgttgccgg gccttaggat 6841 ggtgtcatgc aaatacacaa acggaaacgg acagcctgta tcgggtggca cagtcacttc 6901 cgcatgactc gactcgtctg gaaatgttca agagactggc acaaatagag cagctgactc 6961 ccaggtgtat caccttctcg ggtctgttgc gcgaggaagc caccttgcag aagaatgaca 7021 gatacaacgc catagccgcc tatctgcaca cagtgtacta ctataaccaa aacaaccggg 7081 acagcgtaaa aaaatggctt gacacaatgg agccttatgc ccgcaaatcg caaacctggg 7141 atctctattt cgatgcgctc cgctttcaga tagacctctg cacctacgaa gagcagtatg 7201 aacttgccat caacgaagcg aacctgatgt acgaaagagc ccaaaaagtg aactgcgccc 7261 gcggactgat cggagcaaaa caatgcttgg gcaacgtcta tatcagtaca gagagatggg 7321 acgaaggaat gaaagcattg gaagctgcct atcaactctc tttacaaaca gataatgcgg 7381 tagtacgaat ctcgattctc tgtcaactga tttccataac caaggatcag aaaaacaacc 7441 aattactctc cgaatacctt gcgaagctaa aagaaacact gcatcaccat acctccacga 7501 acccgatgct caaagaggca ttttatgatg tttacctgtt ctgcgaagta tattacacct 7561 attattatct atatgcaggc cagccggaac aagcacataa aaatctggtt aacgcgggca 7621 aatttctcaa tggcaacacc ttctttctct acagggtgct ctattacgat gcctatgcag 7681 catacttccg ggcttgcaaa gcgtatgacc gggcacttgc caagatagac tccaccatca 7741 tactgctgca agaggacttc aacagcaatt acatccacca aaaattgaca aaagccgacc 7801 tcctggcaga agccggacga agtgcagaag ccattcccct gtacatcgaa acactccatc 7861 ttaaagactc tatcgaaacg accgttctcg acaaacagat gcaacagata aaagctaaat 7921 acaacatcga caaagtggca ttggaagagg aacggctgaa aagctacatc caactcggca 7981 ccttaatagt ggtggtcatt atcctgataa ttctggttgc tttcatgctc cgcatttcac 8041 acgtacgcaa ggctttggaa cgatcggaaa aagaaacacg ggaaacaacc cgtatggcgg 8101 aagaagccaa tgaaatgaaa aatcgctttt tgtcgaacat aagctatcac atccgcatcc 8161 cgctgaacgg tgtagtgggt ttctctcaac tgatagcctc cgagcccaac atgcccgatg 8221 agctccgtaa agaatactct tccatcattc agaagaactc cgaagagttg atgcgcctgg 8281 ttaatgatgt actcgattta tcacggctcg aagccggtat gatgaagttc aacattcagg 8341 agtacggact ggcggaactc tgcaatgaag ctacctatat ggcgcgcatg catagtgaag 8401 ggtgtaccgt catccgtttg gaaaacgaaa ttgacacaga cctgaacatc cgggtagaca 8461 ccgtccgttt cacacaggcg ttgctgagtg cactgacata tccgcagaag tacaaagaaa 8521 aacgggaaat cgactttaag gtgacactcg acacggagaa gaacttcatc aacttccgca 8581 tcaccaactc tccgctggct gacgaaagat ttacttcgca agaggtatgc atccgtcacg 8641 aaatcaaccg cctgctattt gagtatttcg gaggaagcta caaagtacag acaaatccgg 8701 acggaaagcc gaccatcctc ttcacgtttc cctcaggaag aaattgactt cttcccctat 8761 ccgctcgtct acttctacag aaagttgtat ctttgcaacc tgcaaactta aacccttctt 8821 tatgtatacc aacaaacaga tctggagtgt cagttacccg attctcctga gcttgcttgc 8881 gcaaaatgtc atcaacgtca ccgacactgc ctttctggga cgtgtcagtg agatagccct 8941 cggtgcttct gccatgggtg ggcttttcta tatttgtatt ttcaccattg ccttcggatt 9001 cagcaccggt tcccagatcg tcattgcccg ccgcaacggt gaagcacgtt acggcgatgt 9061 aggtccggtc atgattcagg gagtcttgtt cctgttggtc atggctctcc tgctcttcgg 9121 attcaccaaa gcgttcggcg gaaacatcat gcgcctgctg gtctcttccg aaagcattta 9181 tgatgccacg atggagtttc tcgactggcg catcttcggg ttcttcttct catttgtcaa 9241 cgtgatgttc cgggcactct acatcggaat cacccgcacc aaggtgctca ccatcaatgc 9301 agtggttatg gcgctgacca atgtggtgct ggactatgcc ctgatattcg gacacttcgg 9361 gcttccggaa atgggcatca aaggagcagc cattgcttcc gtaatcgccg aagcggcttc 9421 tctgctcttt ttcctgattt atacgtacat caccgtcgac ctgaaaaagt atggcctcaa 9481 ccgcttgcgg tcgttcgacc cggttttgtt gatgcgcatt ctcagtatat cgtgcttcac 9541 catgcttcag tatttcctgt cgatggccac ctggtttgtt ttctttgtgg cagtggagag 9601 gttgggacag cgcgaactcg ctattgccaa catcgtgaga agcatctaca tcgttatgct 9661 gattccggta aatgcactgg ctaccacaac caacagcctg gtgagcaacg ccatcggcgc 9721 gggaggcatc aactacgtga tgccgttgat aaacaaaatc gggcgcttct ctttcctgat 9781 catgctgggg ctggtcatca taaccgccct gttcccacaa gcattgctct cggtatacac 9841 caacgaaacg gcattgatca atgaatcggt atcatcggta tatgtcatct gcgtggccat 9901 gctgattgcc tctgttgcta acatcgtctt caacggaata tcgggtacag gcaatactca 9961 agcagccctg atgctcgaag ccatcacgat tgcaatctac ggatcgtaca tcattttcat 10021 cggaatgtgg gtgaaagctc ccatcgaatg gtactttacg attgagattc tgtactatac 10081 actgttgctc gccacaagct atatttattt caaaaaagca aaatggcaga acaaaaagat 10141 ataaagtacg agagattttt gtacatttgc ggctgatttc accgcagatt gcacagatta 10201 gcacagatat tctctatgtc agatataaaa tccgtgtcga tccgtacaat ttgcggcggg 10261 ctttacacat cattagtaat tcataattca aagatatgtt cgacaattta agcgaaagac 10321 tcgaaaggtc gtttaagatt ctgaaaggtg aaggcaaaat caccgagatc aacgtagcag 10381 aaaccctgaa agacgtgcgc aaggcactgc tcgatgccga cgttaactat aaagtagcca 10441 aaggattcac tgatacggtg aaggaaaagg cactgggaca gaacgtgctc acagccgtaa 10501 aaccgagcca gttgatggtg aagattgttc atgacgaact gacccagctg atgggtggag 10561 aaactgtcga aatcgacacc aaaggtcagc cggcagtcat cctgatgtcc ggtttgcaag 10621 gttcgggtaa gaccactttc tcgggtaagc tggcccgcat gctgaaaacc aagaagaaca 10681 aacgcccgtt gctcgttgca tgtgacgttt accgtccggc agctatcgag cagcttcgcg 10741 tactggccga acagattgac gtaccgatgt actcggagat cgacagcaaa gatccggttt 10801 ccatcgccca gaatgccatc aaagaagcac gtgccaaggg atacgatctg gtaattgtcg 10861 atacggccgg acgtctggca gtcgacgaac agatgatgaa tgagatcgct gccatcaaag 10921 aagccatcca gcccaacgaa attctgttcg tggtagactc tatgaccgga caagatgcgg 10981 tcaacacagc caaagagttc aacgaacgcc tcgactttga cggcgtggtg ctgaccaagc 11041 tcgacggtga tacccgcggt ggtgcggccc tctctatccg ttcggtagtg aacaaaccta 11101 tcaagtttgt aggtacgggc gagaaactcg atgccatcga ccagttccac cctgcccgta 11161 tggccgaccg tatcctgggt atgggtgaca tcgtttcgtt ggtggaacgc gcacaggaac 11221 aatatgacga agaagaagct aaacgcctcc aaaagaagat tgccaagaac caattcgact 11281 tcaacgactt cctcagccag atctcccaga ttaagaaaat gggtaatctg aaagagctcg 11341 cttcaatgat tccgggtgtg ggcaaggcca tcaaagatat cgatatcgac gacaacgctt 11401 tcaaaagcat cgaagccatc atctactcca tgactccgga ggaacgcagc aatccgggca 11461 tcctgaacgg ttcgcgccgt acacgtatcg ccaaaggtag cggtacgact atccaggagg 11521 tgaaccgtct gctgaaacag tttgaccaga ctcgcaaaat gatgaagatg gtgaccagca 11581 gcaagatggg caagatgatg ccgaagatga aataagactg cacttttctt cccgaaagct 11641 tgactttggc ttcgggatga tgtatctttg tctatgtaat cattcaataa attcaattag 11701 aatgcaatag aaggaggaag ccgctgtttc ctcctttttt tatgtaccta ccagagtaag 11761 aaaccataac ccgccgcttg aagtcccgga gacggttgct ccactcccga ataccggctg 11821 cattgcagtc agatgcttac tgcatttcag taaaaccccg gctctacccg catcggatcc 11881 cggctctatt cccagaagtt cctctttgcc ttcggaactc ctccccaccc tgttaataat 11941 ctataaagct actcttgaca aaaaacaggg aatggtaaat gatattactt ttgcctgata 12001 ccataaaagc attgaatcaa tgaaacacat tctcttcact ctggcgcttg cttccatagc 12061 cgggatagcc aacgcacaac acaatgggca ctcctatacg gtagaaggtt tgataaacga 12121 ttctaccctg aacggacaga cactctatat cagccgttat gacgacggaa tgaaagtgga 12181 tagcacgcaa gtgaccaacg ggcaatttaa attcaccgga aaagcggaca tcccctgttt 12241 ttgccgcatc gatgcgggga gagagtatgc caacttcatc ctcgaagggg gcaacatcca 12301 ggtcaatgta ctgactcaca atgacccgaa gggaacgcca atgaatgagg agtataccca 12361 catatctgat aagacatccg agctggtcac agagttgaga aaaagacatg cggccatcga 12421 acagcaaaca gaagacaaat cggaacaact ccggcttaaa aaagaatacg ccgatactta 12481 ctggcatccg acttataccc gactatacaa agacatgttt atgaagaacc cggacaatgc 12541 actcggagag tttgccatca gagagcttgc catgtgcgct ttgcccgaag agatggacac 12601 catatttgcg gcttccggcc cctggttgaa gtcactgagc gtatatcatc gcatcgaaaa 12661 gcagtttcaa ggcatgaaag cgacggcagt aggacaaaag tttaccgact tcagcggtaa 12721 gactatagac ggtaccgcaa gctctttatc cgattttgtg ggcaaaggtc aatacacttt 12781 ggtagatttc tgggcaagct ggtgtggccc ctgccgttcc gaatcgcctc atatagccga 12841 actctacaac acatacaaag acaaaggact gactgttctg ggagtagcag tctgggacaa 12901 accggaaaat actaaaaaag cgatcaagga actcaatatc gactggccgc aaattatcga 12961 caccggtatg acgcccatgg atctgtacgg tgtaaaaggt atccctttca tcctcctctt 13021 cggacctgac ggaaccatca tcgcacgtga cctcagagga gaaggaatga aaaataaagt 13081 agccgaagta ctaaacaata aataactcaa taaacgaata agaaatgaca ctgattgatg 13141 gaaaagccat ctccgaacaa gtaaagcagg agattgcagc cgaagtggca gaaatagtgg 13201 ctcatggagg caaacgccct cacctggcag ccatcctcgt aggacacgac ggaggcagcg 13261 agacatatgt agccgccaaa gtaaaagctt gcgaagtgtg cggattcaag tcgtcactga 13321 tccgttacga aagtgatgtg acagaggacg agctgcttgc caaagtacgc gaactgaatg 13381 aagatgacga tgtagacgga tttatcgtac aacttccgtt gcccaaacac atctccgaac 13441 aaaaagtgat tgagaccatc gattaccgca aagatgtgga cggatttcac ccgatcaatg 13501 taggacgcat gtctatcgga ctgccttgct atgtatcggc cactccgaat ggaatcctcg 13561 aactgctgaa acgctaccgg atagagacat ccgggaaaaa gtgcgtcgta ttgggacgca 13621 gcaatattgt tggcaaaccg atggctgcac tgatgatgca gaaggcttat ccgggagacg 13681 ctacggtgac cgtatgtcac agccgctcaa aagatctggt gaaagagtgc cgggaagccg 13741 atatcattat cgctgcattg ggacaaccca atttcgtaaa ggcggaaatg gtgaaagaag 13801 gtgccgtggt cattgacgta ggtaccaccc gggtgcccga tgccagcaag aagtccgggt 13861 tcaagctcac aggagatgtg aagtttgacg aagtatcccc gaaatgttcg ttcatcactc 13921 ccgttccggg aggagtcggc ccgatgacca tcgtgtcact gatgaaaaat acattgctgg 13981 caggtaagaa ggcgatctat caataaccca ttcctccgtt tccctctcta tgaagaggga 14041 aacggagaat ttgcttttca ataccttagt atcatgaata cgatatttaa aaccacaggc 14101 ttgtgcgtct ttctcttcac atgtacccca tgggctaccg cacaaaattt ttctatcgac 14161 tatccctcat atcaaaaaag aaataccgac gcacttgaaa tcagccggat cgtccgtaat 14221 gacacagcta ccattctgta tatggatgct tactcgcgcc ctaactattg gatacggctg 14281 gcttcggagc tctctctaca cggggtgcaa agcgggaaga aataccctgt catccgatcg 14341 caaggtttcg aactggacaa gcaggtatac atgccggctt cgggcaatgt gacgtttact 14401 ctgcaatttg cccctatcga tccgcaggac cggacgatag actttgtaga aagcaacaat 14461 gaagaagact tccggatcga gggaatttgc cttgacgcat ctgtccccaa aaagaaagta 14521 cactgccacc tggccggcaa aatggcaaac cgaccacaaa ccagtcgcct gatacttata 14581 gaaagcaaca agaatacacg cggtaccccg tggatttcga taccggtgcg caacggtgtc 14641 tttgagtacg acttctatac cgaccacgaa aaggcttacg agcttatttg ctgggacgac 14701 ctgttaaacg gttgctggta tccggtcact ttctttgcag aaaatggaac ggtatctttc 14761 accatatctg ccatagacgc acgcccaccc tatcgcatag agaccctcaa cccactgacg 14821 acggccctcc ggctatttga agcggaaggg gaggataagt tcagtttcga tgaactcaac 14881 gcacgaagag atacgctcga aaaatacgga cgttttgaaa gtgaagccat gcaagcactc 14941 tggaaaaaat tcgatcaggt gaaagacaat cccgaagaaa gaaacaagct tttcagagaa 15001 agagaccgcc tggaagaaag tggcgaagca ttcacagaag aagcaaaagc acttataaag 15061 gaaagggaac aactctttcg gaaaaaagta atttgggaaa cggaacaagc ctcgcaacac 15121 ccttcgctgg tgggactatt tatcctgaaa atgaaggtgg agaacgcacg gaaagatgaa 15181 gatgtcatcc cctatctgga agtatttcaa aaagtgtatg cctcccgcta tcccgaacat 15241 ccctataccc gggaaatgca aatgtttatc gacaataacc aacccaagac gggaaaccgt 15301 ttcatcgact tctccgctcc cgacctgaat ggtaacatgg ttcagttgtc cgaacagata 15361 cggggaaaag tggctctgat cgacctatgg gcttcctggt gcggtccgtg ccgtacgacc 15421 tccaagcaat tgattcccat ctacgaaaaa tataaagacc gtggattcac cgtcatcggc 15481 gtcgcacgcg agcagaacag cgatatccgt atgagagaag ccatacggaa agacggttat 15541 ccctggctga accttatcga gctgaatgac gttcaacaga tctggtcaaa ataccggata 15601 ccgaacgctg ccggcggaac tttcctcgtg aacgcccaag gaatcattct tgccgtgaac 15661 cctacagccg aagaggtgga acgtattctc cagaaagaac tttaatatcg gtaatttatg 15721 aaacatctga ttcttctttt tctctttttt tgttctgtat cttgcagtag caacgcgcaa 15781 gagcaacctg tccctacctc atcggccgac acaatacccg cacagaagat caccctcctc 15841 tttgcaggcg acctgatgca gcatcaggca cagatagacg cagcccggac agcaaccggg 15901 tacgactata cagactactt taaactgata aaagaagaaa tcggcaaagc agacatcgcc 15961 atcggaaatc tggaggtaac cctcggtgga aagccctatc gggggtatcc ggccttcagt 16021 gctcccgacg aatatctgac cgcaatcaaa gatgccggct tcaacgtatt gataacagcc 16081 aacaatcatt gcctcgaccg aggcaaaaaa gggttggaaa gaaccatcct gatgttggat 16141 tccctacaaa ttccgtatgc cggcacctac accgacagca cggcccgtgc ctcgcggtat 16201 ccactcttgc tggaacagaa tggcttccgc attgtcctgc tcaattatac atatggcact 16261 aacggcatca aggtatctgc ccccaacatc gtcaattata tcgataagga tattatggcc 16321 cgggacatcg aaactgccaa agcattgaac ccggatgcat tgattgcatg tatgcactgg 16381 ggcatcgaat accaatcgct gcccaacaag gaacaaacat ctcttgccga ctggttgctt 16441 agccggggag tcacccatgt gatcggctcc catccacacg tggtacagcc catggagttg 16501 cgaaccgata cgctcagcgg acagcaaaat gtggtgcttt actctttagg taattttatt 16561 tcgaacatgt ctacccgcaa aacagacggg ggactgctct ttaaactcga attaacgaaa 16621 aacagtatag gcacatctgt cagcaattgc gggtatagtc tgatatggac tgcacgcccc 16681 acactctcca aaaagaaaaa ttacgtttta tacccggcaa gcattccgac agactcttta 16741 tcggcagaag aacgtaaccg cctgaaaatc tttattaatg acacccggga actcttccgc 16801 aagcataacc gcggaattaa tgaatacatt ttttgaagaa aaaagttcgc agaatgtttg 16861 cagattcaaa aagaatcgct acctttgcat cgcatttgag agagatgcta acatggtggc 16921 tgtagttcag ttggttagag cgtcagattg tggttctgaa tgtcgtgggt tcgagtccca 16981 tctgccaccc aacaaagaga ggaaattcat tattgaattt cctctctttg tttatataag 17041 gcaattaagg atcaacataa gtgaaagacc tgtctgccaa agacacagga ttataaaaaa 17101 tctgcagaag caggatcaaa atcccgcctc tacagaaaac tgtaaaccat taaaacaaaa 17161 tgcaccttgt cagaccacaa ttaaaaacga ggcataacaa acttgtcatc aggggatgta 17221 aaggataatc ccggaacaga gcggcgcata tctttataag cgtattcttt aattagtgaa 17281 tagtcagtag catccaaagc ataataatag tcatctttat ccgttgataa ctttacagtc 17341 caatcgaaca tatttccaaa gatagtcaac tcgtctttgg tgggatcgaa accgggaaga 17401 gctgatttaa ccaaatttcc atcactgttg atcacataaa aatgatgctg gctgtctacc 17461 atatacccca aagtccggcg actgcggaac tcagtaataa atacatattc cggcaaaacg 17521 ccttcaggca gctgaatcag tttcacatac ggacgtccct tggtacactt cagatgaaac 17581 agtttatggt tggcatccaa aaccagatac ccctcatcat agtctttacg ggtagtcgga 17641 ttgcccgaag catagcttgc gggaaaagca aaccctttct gaaccagcat ctccgtaaac 17701 aattcactct tcgcctcatc tatacgattc gtctccatac gaataaattc gataccttta 17761 tcggtaaagc gaaaagcatc ttcgggcatt ttcaaatcca cccgcttgga catggactcc 17821 atcaggaaat aaagtcctgt ttggggagca ttgatagctg acggcacact cttgaaagta 17881 aagttagtca actggatgtc tttcggacta actgccctac cgcaaatggt atcgggaaaa 17941 cgttcgtctg ccgtaagctg acgtacgtaa agagaaggta acagactgtc gacctgttgt 18001 tgtgtatatg tattgccttt cgtatcataa cggtgaagct gcttattctc atccagttgc 18061 gtaatgacaa aatcaccaag cacggaacta tacatagtaa aaggagtctt ggcaggcttc 18121 aatgtgagaa aagcatagca ccaaggcaac tgccatacaa gcagcacagc cacagtaaca 18181 taaaaaaaca ttttgctgaa tcgaatcat //