LOCUS NC_003485:10 18947 bp DNA linear BCT 03-OCT-2011 DEFINITION Streptococcus pyogenes MGAS8232, complete genome. ACCESSION NC_003485 SOURCE Streptococcus pyogenes MGAS8232, complete genome. COMMENT locus start: 1707653; locus end: 1726599 FEATURES Location/Qualifiers source 1..18947 /organism="Streptococcus pyogenes MGAS8232, complete genome." gene complement(0..1712) /gene="spa" /locus_tag="spa" /db_xref="1707653..1709365" CDS complement(0..1712) /gene="spa" /product="streptococcal protective antigen" /translation="MFLRNKKQKFSIRKLSAGAASVLVAASVLGGGVSAYADSVSGLE VADPSDSKKLIELGLAKYLNDKLPFKTKEDSEILSELRDVLKNANPETLKSLLNGMDQ GHISFSDRNNRYNRLSQYINSFRKDDDDYLHNGYSLGSLVIEAIKYRLDSESHLKEEL LKQTAELEQRKNAEVDLKSEKKRLEAQIEKVGYDIANKQQELEKARSDQKELSESIQK LTSRFKKESDAKQKELDEAKAANKSLSESATKTLARSSKITNELKDKLAASEKDKNRA FQVSSELANKLHETETSRDKALAESKELADKLAVKTAEAEKLMENVGSLDRLVESAKR EMAQKLAEIDQLTADKAKADAELAAANDTIASLQTELEKVKTELAVSERLIESGKREI AELEKQKDASDKALAESQANVAELEKQKAASDAKVAELEKEVEAAKAEVADLKAQLAK KEEELEAVKKEKEALEAKIEELKKAHAEELSKLKEMLEKKDHANADLQAEINRLKQEL ADRIKSLSQGGRASQTNPGSTTAKAGQLPSTGESANPFFTIAALTVIAGAGMAVVSPK RKEN" gene 1942..3147 /gene="" /locus_tag="" /db_xref="1709595..1710800" CDS 1942..3147 /gene="" /product="putative transcriptional regulator" /translation="MKGVTLSMDTMSLVKSLQACLKLSITVFDKDHQVTESFWNNDTF EFYYRFQAVLRQMDKEQATNLFFQGSYNELFLIYRYQDHYILIGPWRCNVLDKTFFKV TVADKDLTKEEEEILYQALKHLPVYPLNAIRDLLIVVHYFFSGKIEDLLSPPLRHYIR DFSDNIEVEKANMFVKKQESKVCLYNYEKNLSTIVQEGDVHKLKEIIFSLRNTFIPVV SGDTLRSEKNYSIIAFDRLAQIAIQSGMDIADAYHSRQEFMRDSELATSMPDVLKIRD ASLVFYTQKVSELRDNRWKHASPAVNAIIQYISVNLHKSITTAELAQHFNMSESKLRQ IFKRDTGLTIYQYTSNMKIEETKTLLRSAYAINHISDVLGFTDPSHFSKFFKKHTGES PKAYQNRKH" gene 3357..3815 /gene="nrdI" /locus_tag="nrdI" /db_xref="1711010..1711468" CDS 3357..3815 /gene="nrdI" /product="hypothetical protein" /translation="MTDLTLIFISLSGNTLSFVRRLSQYLAEKHHIQTKTINIKELHH ETFPVMESFVAILPTYLEGGNGIDSGKVEILTNPLGDFIAAHDNVKHCLGIIGSGNKN FNHQYCLTAKQYAKRFGFPMLGDFELRGTNADIERLAQVIVARLTADQQS" gene complement(4118..4939) /gene="" /locus_tag="" /db_xref="1711771..1712592" CDS complement(4118..4939) /gene="" /product="hypothetical protein" /translation="MTKVLTLNTHSWMQANTLKKLVALAEHILAEKYDIICLQEINQL IESELATDLPRYQALSGTPSIHKDHFALLLIHYLQKRGQHYYWSWAYNHIGYDIYQEG VAILSKQPIHVSDTLVSAMADETDYHTRRALLGQTTIDGREVAVVSLHLSWFDKGFVE EWQRLEAALQQLTCPVLLLGDFNNPSGQEGYELILKSPLELQDSHQAADYVFGDHSIV AAIDGWEDNKEAFKVDHVFTSKAFTINSSKVTFDGGEAPVVSDHYGLEVDLNWKL" gene complement(5022..7208) /gene="ptsG" /locus_tag="ptsG" /db_xref="1712675..1714861" CDS complement(5022..7208) /gene="ptsG" /product="putative PTS system, enzyme II, A component" /translation="MKTSFKQLFRFEFWQKFGKCLMVVIAVMPAAGLMISIGNSIPMI NHDSAFLASLGNIIAQIGWAVIVNLHLLFALAIGGSWAKERAGGAFASGLAFVLINRI TGAFYGVSSAMLADPEAKITSFLGTQMIVKDYFTSVLESPALNTGVFVGIIAGFVGAT AYNKYYNYRKLPEVLTFFNGKRFVPFVVILRSIFVALILVVVWPVIQSGINSFGMWIA SSQDSAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYEVMTGAAAGTKVFGQ DPLWLAWVTDLVHLKGSDASAYSHLMDSVTPARFKVGQMIGATGTLMGIALAMYRNVD ADKKHTYKMMFISAAAAVFLTGVTEPLEYLFMFAAMPLYIVYALVQGASFAMADLVNL RVHSFGNIELLTRTPMALKAGLGMDVINFVWVSILFAVIMYFIADMMIKKMHLATAGR LGNYDADILGDRNTQARPTQVADSNSQVVQIINLLGGAGNIDDVDACMTRLRVTVKDP AKVGAEDDWKKADAMGLIQKGNGVQAVYGPKADVLKSDIQDLLDSGALIPEVNMSQLT SKPTPAKDFKHVTEEVLSVADGMVLPITGVKDQVFAAKMMGDGFAVEPTNGNIYAPVA GLVTSVFPTKHAFGLLTDNGLEVLVHVGLDTVALNGVPFSVKVSEGQRVHAGDLLVVA DLAAIKSAERETTIVVAFTNTAEIQDVTLTSLGNQPAKTKVATVEL" gene complement(7564..8313) /gene="" /locus_tag="" /db_xref="1715217..1715966" CDS complement(7564..8313) /gene="" /product="hypothetical protein" /translation="MQQYFIKGKAEKKVTITDKDTIKHMFQVMRLADKAEVVLVFDDG VKYLAKVTNSMAHELEIIEALPDQVELPVKVTIASGFPKGDKLDTIAQKVTELGASAL WGYPADWSVVKWDGKKLAKKEDKLAKIVLGAAEQSKRNVVPEVHLFEQKAEFLKSLSS FDHIFIAYEETAKAGQLATLAREVKEVKLGAKILFIFGPEGGISPTEITQFEAAGAIK VGLGPRIMRAETAPLYALSVLSYALELQASK" gene complement(8313..9266) /gene="prmA" /locus_tag="prmA" /db_xref="1715966..1716919" CDS complement(8313..9266) /gene="prmA" /product="ribosomal protein L11 methyltransferase" /translation="METWQEVTVHVHRDAQEAVSHVLIETGSQGVAIADSADYIGQKD RFGELYPDVEQSDMIAITAYYPSSTNLADVIATINEQLAELASFGLQVGQVTVDSQEL AEEDWADNWKKYYEPARITHDLTIVPSWTDYDASAGEKVIKLDPGMAFGTGTHPTTKM SLFALEQILRGGETVIDVGTGSGVLSIASSLLGAKTIYAYDLDDVAVRVAQENIDLNQ GTDNIHVAAGDLLKGVSQEADVIVANILADILVLLTDDAYRLVKKEGYLILSGIISEK LDMVLEAAFSAGFFLETHMIQGEWNALVFKKTDDISGVIGG" gene complement(9337..9807) /gene="" /locus_tag="" /db_xref="1716990..1717460" CDS complement(9337..9807) /gene="" /product="hypothetical protein" /translation="MAKYGFLSVLEEEMDKHFQYDYAMDWDKKNHAVEVTFVLEAQNK EAIKTIDDSGEVTQDDIVFEDYVLFYNPAKSQFDAADYLVTIPFDAKKGFSREFLAYF AQFLNDVAIEGHSDLMDFLADDSKADFGLEWNAQAFEEGQQGLEEAASYPYPRY" gene 9980..11953 /gene="" /locus_tag="" /db_xref="1717633..1719606" CDS 9980..11953 /gene="" /product="putative amidase" /translation="MRYSRRYPSQTRQMLLALLLMTVSLQAGAMTTYADEVNTNHQPL TAQVEASKPTAMESVTSPADQTHPISTQEASSPLHPLTTEATPAAQESPITLEDYKAA SASQLAEWARQQRVTGQQLLDFALETIKETNPELNNVISLREPLARQESEQMTDEGQP FYKVPILVKGLGHTVAGSSNTNGLAFLKDKTSSSTSAFVKQLQKAGFIVVGQSSFPEM GWINVTNSNLYGNTHNPWQLDQNPGGSSGGSAAAVASGQVSLASASDGGGSTRIPASW SGLIGLHPTRGILEGNPTSERSNVSHFALTKSMEDTEKLFQFLLKDKAKAQQNLQRLD TSIPIAYSTQTPAGTPISEEAIAAIKEAVAFLQEQGYQTVEVPYPVDGKLMMQYYYTI AASAAPSINFMAQQTLKRPLQKEDVELLSWALYQTGKDLTKEDVNKAWEGIAAMTEQL NQFYQKYPIFLTPTTAYPAPAADYHHIPKDLVAQLSDMSGLSKEEKLDLIYRQWLPAW TLTPFTQLANLTGTPSLSLPTHVTKSGLPLGILVNSGAHNDSLLLQLGQLFEKANRFH ILTAGKKGLPETPTHEHNLSTQSENKQGVAIPVTYQTKGFTAGPTKGQNGLVTLPQTG DGQSKGVLLSSYISLFLGTLFLAGSFWSNKLKD" gene 12138..13895 /gene="" /locus_tag="" /db_xref="1719791..1721548" CDS 12138..13895 /gene="" /product="putative para-aminobenzoate synthetase" /translation="MHRKTIIDFKELGRRYLFDEPLVELVAKSLDQVGPVIEKVQHYQ QLGYYVVGYLSYETAAFFDNALQTHNNRLGNEYLAYFTVHKTCQKEDLPLDYDSITIP NQWVSATQKEAYQKAIESIHREMQQGNTYQVNYTIQLTQELNAADSLAIYNKLVVEQA AGYNAYIAHDEFAVISASPELFFKQEGNQLTTRPMKGTTKRGVNTWLDQQEHDWLQAD GKNRSENMMIVDLLRNDMGKICQIGSVCVDRLCEVERYSTVWQMTSTIVGDLKADCDL IDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTI QLSHNQATYGVGGGITWQSKWEDEYEEVHQKTAFLYRHKQIFDLKTTAKVKHQKIAFL EQHLNRLKEAATYFAYPYDEKALQKQLATYLENKDNAAYRLMIRLSKDGKISLSDQPL EPLSAEFLTAQLSLQKKDVTASPFTYFKTSYRPHIEQKSYEQLFYNQAGQLLETSIGN LFIQLGRTLYTPPVAVGILPGLFRQELLATGQAQEKEVTLADLKEASAIFGGNTVRGL YPLNLELTHLDALLAKSQA" gene 13928..14494 /gene="" /locus_tag="" /db_xref="1721581..1722147" CDS 13928..14494 /gene="" /product="anthranilate synthase component II" /translation="MILLIDNYDSFTYNLSQYLSEFDETIVLYNQDPNLYDMAKKADA LVLSPGPGWPKEANQMPKLIQDFYQTKPILGVCLGHQAIAETLGGTLRLAKRVMHGRQ STIETQGPASLFRSLPQEITVMRYHSIVVDQLPKGFSVTARDCDDQEIMAFEHHTLPL FGLQFHPESIGTPDGMTMIANFIAAIPR" gene 14527..15795 /gene="" /locus_tag="" /db_xref="1722180..1723448" CDS 14527..15795 /gene="" /product="hypothetical protein" /translation="MPDHLALRMRPKTISEVIGQKHLVGEGKIIRRMVEANRLSSMIL YGPPGIGKTSIASAIAGTTRYAFRTFNATIDSKKRLQEIAEEAKFSGGLVLLLDEIHR LDKTKQDFLLPLLENGTIIMIGATTENPFFSVTPAIRSRVQIFELEPLSNEDIKTAIQ LAISDKERGFPFLVTIDDEALDFIVTATNGDLRSAYNSLDLAVMSTSPNEDSSRHISL ETMENSLQRSYITMDKNGDGHYDVLSALQKSIRGSDVNASLHYAARLVEAGDLPSLAR RLTIIAYEDIGLANPDAQVHTVTALDAAQRIGFPEARILIANVVIDLALSPKSNSAYL AMDAALADLRTSGNLPIPRHLRDGHYAGSKDLGNAKDYLYPHAYPEKWVKQQYLPDKL VGHHYFEANETGKYERALGSNKERIDKLLD" gene 16293..16733 /gene="" /locus_tag="" /db_xref="1723946..1724386" CDS 16293..16733 /gene="" /product="pai1 protein" /translation="MKIIEYKGNYRDDLIFMVLEAKNALRRIPSINPDLLTIETSYLE KGDCFWLAVNEESRVIGSIAYSSIPKTNEVFLHRLFIKPSLKHQGIGSQLLTFAEDYL RKIGKSHVRIHLGQPKEQWFESYRFYPKHGYQFYDDTHLIKKLI" gene 16788..17294 /gene="" /locus_tag="" /db_xref="1724441..1724947" CDS 16788..17294 /gene="" /product="topology modulation protein" /translation="LKIAIIGHSGSGKSTLARFLGQHYHCEVFHLDQLHFSSNWQERS DHDMIADLSTCLLKQDWIIEGNYANCLYEERMSEADYIIYVNFSRFHCVYRAFKRYLN YRGKTRPDMADNCQEKFDVAFVKWILLGGRSRNQLKKYQSVVQKYSHKTIVLTNQKQL SHYMNTIN" gene complement(17422..17586) /gene="" /locus_tag="" /db_xref="1725075..1725239" CDS complement(17422..17586) /gene="" /product="hypothetical protein" /translation="MNIEVKEKISFVFFINSLFSGAIILLCFNITLSKEIIINNFLDI LADYRMKIET" gene 17543..18244 /gene="SMEZ" /locus_tag="SMEZ" /db_xref="1725196..1725897" CDS 17543..18244 /gene="SMEZ" /product="mitogenic exotoxin Z precursor" /translation="MKKTKLIFSFTSIFIAIISRPVIGLEVDNNSLLRNIYSTIMYEY SDTVIDFKTSHNLVTKKLDVRDARDFFINSEMDEYAANDFKDGDKIAMFSVPFDWNYL SEGKVIAYTYGGMTPYQKTSIPKNIPVNLWINGKQISVPYNEISTNKTTVTAQEIDLK VRKFLIAQHQLYSSGSSYKSGKLVFHTNDNSDKYSLDLFYVGYRDKESIFKVYKDNKS FNIDKIGHLDIEIDS" gene complement(18661..18795) /gene="" /locus_tag="" /db_xref="1726314..1726448" CDS complement(18661..18795) /gene="" /product="hypothetical protein" /translation="MTYFRLKKELNWSLRNKGIVVYEGNQKLQIAINTGKNNSEKSLF" ORIGIN 1 ttagttttct ttgcgtttag gagacaccac agccatacca gcaccagcga tgacggtaag 61 agctgcaata gtgaagaatg ggttagcaga ctcaccagta gatggcaatt gacctgcttt 121 agcagttgta gagcctgggt ttgtttgtga agcacgacca ccttgtgaca atgacttaat 181 cctgtcagct agctcttgct tcaagcggtt gatttctgct tgaagatctg cattcgcatg 241 gtctttcttc tcaagcattt ctttaagttt tgaaagttcc tcagcatgag cttttttgag 301 ctcttcaatc ttagcttcaa gcgcttcttt ttctttctta acggcttcaa gctcttcttc 361 tttcttagct aattgtgctt taagatctgc aacctcagct ttagcagctt caacttcttt 421 ttcaagctct gctaccttag catctgatgc tgctttttgt ttttcaagct ctgctacatt 481 agcttgtgat tctgctaaag ccttatcaga agcatctttt tgtttttcaa gctcagcaat 541 ttcacgttta cctgattcga tcaagcgctc tgaaacagca agctctgtct taactttttc 601 tagctctgtt tgaagtgatg caatggtgtc atttgcagct gcaagctctg catcagcctt 661 agccttatca gcagttaatt ggtcaatttc tgctaatttt tgagccattt cacgttttgc 721 agactctacc aagcggtcta gactaccaac gttttccatt aacttttcag cttctgctgt 781 tttaactgcc aatttatctg ctaattcttt tgattctgct aaagccttat cacgactagt 841 ttctgtttca tgcaacttat tagctagctc tgaagaaact tgaaatgcac gatttttatc 901 tttttctgaa gccgccaact tatcctttaa ttcattagtt atcttagatg atctagctaa 961 tgtttttgtt gctgactctg aaagagattt atttgccgcc ttagcttcat ctagttcttt 1021 ttgtttagca tcactttctt ttttaaatcg tgacgttaat ttttgaatag attcacttaa 1081 ctctttttga tctgaacgcg ctttttctaa ttcttgctgt ttattagcaa tatcatatcc 1141 tactttttct atttgcgctt caagtctctt tttttcagat tttaaatcaa cttctgcatt 1201 cttacgttgc tcaagttctg cagtctgttt aagtaattct tcctttagat gtgactcact 1261 atctaaacgg tatttaattg cttcaatcac taaacttcct aaagaatatc cattatgtag 1321 atagtcatca tcatcttttc taaaactatt tatatattga gataaacggt tgtagcgatt 1381 atttctatca gaaaatgata tatgtccttg atccatacca ttaagtaaac tttttaatgt 1441 ttctggatta gcatttttta atacatcacg taactctgat aaaatctctg aatcttcttt 1501 agttttaaag ggtaatttat cattaaggta tttagccaaa cctaattcaa taagtttctt 1561 actatcagag gggtctgcca cctctaatcc acttactgaa tctgcatacg cacttactcc 1621 ccctcccaac acacttgctg caactaatac tgatgctgca ccagcactta gttttctgat 1681 gctaaatttt tgctttttat ttctcaaaaa catatgtcaa ttcctctcta cccgttatgg 1741 gcatactttt ttgttttacc atactattat agtctcatgg tgcttttatt ttaatggcag 1801 aaacttcttt atgtagtaca ttgttatttt tatttaataa gaaagaatgt atattattgt 1861 ttttttgtgt ctattttttc attataagtg catatccttg cttttcttaa attttaagat 1921 agaataagat accgtaagga ttatgaaggg ggtaacgctt agcatggata ctatgtcgtt 1981 agtaaaatct ctacaggcct gcttgaagtt atcaattaca gtatttgata aggatcatca 2041 ggtgacagaa agcttttgga ataatgatac ctttgaattt tattatcgtt ttcaagcggt 2101 gcttaggcaa atggacaagg aacaggcgac caatcttttc tttcagggaa gctataacga 2161 gcttttttta atataccgtt atcaggacca ttatatttta atcggccctt ggcgctgtaa 2221 tgttttggat aagacctttt ttaaggtgac cgttgctgat aaggatttga ctaaggaaga 2281 agaagagatt ctttatcagg cgctaaagca tttacccgtt tatcccttaa atgccattcg 2341 tgacctctta atcgtggttc attacttctt ttctggtaag atagaggact tgttatcacc 2401 tcctttgcgt cactatatta gagatttttc cgacaatatc gaggtggaaa aggccaatat 2461 gtttgtcaag aagcaggaat ccaaggtctg tctctataat tatgaaaaaa acctatctac 2521 cattgttcaa gagggtgatg tgcacaagct caaggaaatc attttcagtc tacgaaatac 2581 ctttatccct gtagtgagcg gcgatacgct gcgctctgaa aaaaattatt ctatcattgc 2641 ctttgatcga ctagcccaga ttgccattca atctggtatg gatattgctg atgcctacca 2701 ttcacgacag gagttcatga gagacagcga gctggcaacc tcaatgccag atgtgctcaa 2761 aattcgtgat gcctcactgg tcttttacac ccaaaaggtg agtgagctgc gggacaaccg 2821 ctggaaacat gcctctcctg cggttaacgc cattatccaa tatatcagtg tcaacctgca 2881 taagagtatc acaaccgctg agctggcaca gcattttaac atgagcgagt ccaagctgag 2941 acaaatcttt aagcgtgata caggcttaac catctatcaa tacacctcta atatgaaaat 3001 tgaagagact aagacactgc tgcgctctgc ctatgccatc aatcacattt cagacgtgct 3061 gggcttcact gatccctcac atttttcaaa atttttcaaa aaacataccg gagaaagccc 3121 aaaggcttat cagaatcgca agcattagca gcaagagcct cttggtccgg gtaacagcca 3181 acactaagct ctctccataa aaagacttga tgatttggac ttaccgtcct tgtcaccaag 3241 ccttttttta tgtgatgtga ctagtgagct atctgtcaag acactgtcat atgagttgta 3301 tatttacggg tattgtgcta agctggttag gaaactaatc ttctaaagga atcttttatg 3361 acagacttaa cccttatttt tatcagcctt agcggtaata ccctgagctt tgttaggcgc 3421 ttgtcgcaat atctggcaga aaagcaccac atacagacta aaacaatcaa catcaaggag 3481 cttcatcacg aaacctttcc agtcatggag agctttgttg ctattttgcc gacctatctt 3541 gaggggggaa atgggattga ctcagggaag gttgaaatct tgaccaatcc actgggagac 3601 tttatcgcag cgcatgataa tgtcaagcat tgtctaggca ttatcggctc tggcaacaaa 3661 aactttaatc accagtattg tctgacggcc aagcagtatg ctaagcgctt tggctttcca 3721 atgctgggag attttgagct acgtgggacc aatgctgaca ttgagcgctt ggctcaggtg 3781 attgtggcta gactgaccgc tgaccaacaa tcgtaagcta ggggatagac aaaagggagg 3841 cttgactttc tactattgca tgaggcaaat gaaaaaactc aagaggtctg gccagctaca 3901 aggcaccata gatcgtcact atctgataca gagcagacga ggtaactagc ctacagtctg 3961 attggtgcgt ctggcatttg tctgtggctt tctcatctac tcatgacact taaatgcaaa 4021 aaagctctta gaagccttac gataagctta cttctaagag ccaaaataac aatctgtttc 4081 ttgcaatgcc agcagcctgt caagccctgc tggctttttt atagcttcca gttgaggtca 4141 acctctaggc cataatggtc gctgaccacc ggtgcctcac caccatcaaa ggtcaccttt 4201 gagctattaa tggtaaaggc cttactagtg aagacatggt cgaccttaaa ggcctccttg 4261 ttatcctccc agccatcaat agcagcaaca atactatgat ctccaaagac atagtctgca 4321 gcctgatgac tatcctgaag ctctaagggg ctttttagaa tcagctcata gccctcttgg 4381 ccacttggat tgttaaaatc tcccagcaac agcacaggac aggtcagctg ctgtagagct 4441 gcctctaatc gttgccattc ttcgacaaag cccttgtcaa accaagacaa gtgcaggctc 4501 acaacagcta cctccctgcc atcaatggtt gtttggccca gcaaggcccg tctggtgtgg 4561 tagtctgttt catcagccat cgctgacacg agagtatctg aaacatgaat aggttgtttt 4621 gataagattg ccacgccttc ctggtaaatg tcatagccaa tatgattata agcccaagac 4681 caataatagt gctgccctcg tttttgtaaa taatggatca agagcagggc aaaatggtct 4741 ttatgaatgc ttggtgtccc tgaaagagct tgatatcttg gtaaatctgt ggccagctcg 4801 ctctcgatta actgattgat ttcttgcaag caaatgatat cgtatttttc agctaaaata 4861 tgctcagcca aagcaactag ttttttaaga gtgttggctt gcatccacga atgggtattc 4921 agtgttaata ccttggtcat taatcctcct ttataagaca agaagagcca tagggcctaa 4981 accagctatg gctattacct atcactatct cgtgatgttt tgttaaagtt ctacggtggc 5041 tactttagtc ttagcaggtt gattgcctaa agaagtcaag gtcacatctt ggatctctgc 5101 tgtgttggta aaagcaacaa caatggttgt ttcacgctct gctgatttaa tagcagcaag 5161 gtctgctacg actaataggt cacctgcatg aacccgttgt ccttctgaga ctttgactga 5221 aaaaggcaca ccatttaagg cgacggtatc aagtcccacg tgcaccagca cttcaagacc 5281 attatctgtc agtaaaccaa aggcatgctt ggtcggaaag acactggtca caaggccagc 5341 tacgggtgca tagatattgc catttgttgg ttcaaccgca aacccatctc ccatcatctt 5401 agccgcaaac acctggtctt tcacacctgt gattgggaga accatcccgt ctgccactga 5461 tagcacttct tctgtcacgt gtttaaaatc ttttgcggga gtcggtttgc tagtgagctg 5521 tgacatattg acttctggaa taagagcacc tgagtccagc agatcttgaa tatctgattt 5581 caaaacatct gctttagggc catagaccgc ttgaacgccg ttgccttttt ggatcaagcc 5641 catagcgtca gcttttttcc aatcgtcctc agcgccaact ttagcgggat ctttgaccgt 5701 cactcgtaag cgcgtcatac aagcatcaac atcatcaata ttgcctgccc caccaaggag 5761 attaatgatt tgtacgactt gagagttgct atctgctact tgggtaggtc ttgcttgagt 5821 gttacggtca cccagtatat cggcatcgta gttgcctaaa cggccagctg tcgcgagatg 5881 cattttctta atcatcatat ctgcaataaa gtacatgata actgcaaaga ggatagaaac 5941 ccaaacaaag ttaatcacat ccatgcctag acctgcttta agggccatag gggtgcgggt 6001 tagtagctct atatttccaa atgagtgaac acggagattc acaaggtctg ccatggcaaa 6061 tgaagctcct tgaacaaggg catagacgat gtaaagtggc attgctgcaa acataaatag 6121 gtactcaagt ggctcagtta cccctgtcaa aaagaccgct gccgctgctg agatgaacat 6181 cattttgtat gtgtgttttt tatcggcatc cacattacgg tacatggcta aggcaatccc 6241 catcaatgtt ccggtagctc caatcatttg tcctacctta aagcgagctg gagtcacgct 6301 atccattaag tgactatagg ctgaagcgtc tgatccttta aggtgaacaa ggtcagttac 6361 ccaagcaagc cacaaagggt cttgaccaaa tacttttgtc cccgctgctg cacctgtcat 6421 gacctcataa gttccaccaa gagctgtata gttcattggg atcgtcaaca tatggtgaag 6481 accaaatggc aacaagagac gttccaaggt accatatagg aatggggcta ggattggagc 6541 tgaatcttgt gaagaggcaa tccacatccc aaaactgtta atcccagact ggatcaccgg 6601 ccaaacaaca accaaaataa gggctacaaa aatagaacgt aaaataacga caaatggtac 6661 aaaacgcttc ccattaaaga aggtcaaaac ttcaggaagt ttacggtaat tatagtattt 6721 gttataggcc gttgctccta cgaaccctgc aataatccca acaaaaaccc ctgtgtttaa 6781 agctggagat tccaagacac tggtgaaata atctttaacg atcatttgag tgccaaggaa 6841 gcttgtgatt tttgcttctg gatcagctag catagcacta gacacgccat aaaaagcgcc 6901 tgttatccga ttgatcaaga caaaagcaag acctgaggca aaggcccctc cagctctttc 6961 tttagcccaa ctaccaccaa tggccaaggc aaatagcaaa tgaaggttta caataacagc 7021 ccaaccaatt tgagcgataa tgttgcctag agatgccaaa aatgctgagt cgtggttaat 7081 cattggaata gagtttccga tactgatcat taaaccagcc gctggcatga cagcaataac 7141 gaccataaga catttcccaa atttttgcca aaattcgaaa cgaaacagtt gtttgaatga 7201 tgttttcatt ctatctctcc tttattatcc ccttttagcc atagctgccc ttaaggcgct 7261 tttgtgacac aatgatatag actacaactc agtgatgcaa tcgcttgcat tgatctgata 7321 cctttattat actagcctcg caacaatttg taaagcgttt tcttagacag atgttagtcg 7381 tttttcttca ttaaatggta gtgtaactta ccaaaaagat gacaagagcc catttccttt 7441 tttggtgatg agcccatcaa cgctcttcaa aaaacaaaaa gcgataaaaa aaggccgttg 7501 acacaatcgt gaactgcctg ttcgtttctt tagcctcttc tttctaaagt aagcaacagc 7561 ttacttattt tgatgcctgc aattccaaag cataactaag aacacttaag gcatatagcg 7621 gcgctgtctc tgctcgcata atgcgagggc ctaagcccac cttgatggca cctgctgcct 7681 caaactgagt gatttcagtt ggggaaattc ccccttctgg tccaaagata aagaggattt 7741 ttgcccctag cttaacttct tttacttcac gcgccaaggt cgctagctga cctgccttag 7801 ctgtttcctc ataagcaatg aagatatgat caaagctaga aaggcttttt agaaactctg 7861 ctttctgttc aaaaagatgc acttctggca ccacatttcg tttgctctgc tcagcagctc 7921 ctaatacaat cttagccaat ttgtcttctt ttttagctaa ttttttgcca tcccatttga 7981 ccactgacca gtctgctggg tagccccaca gagcactggc tcccaactca gtcactttct 8041 gggcaatcgt gtctaactta tctcctttag gaaatccaga agcaatagtc accttaacag 8101 gcaattccac ctgatctggc aaagcctcta taatctctaa ctcatgagcc atactattgg 8161 tcaccttggc taaatacttc accccatcat caaagaccaa gacaacttca gccttgtcag 8221 ccaagcgcat cacttgaaac atgtgcttga tggtatcttt atcggtaatc gttacctttt 8281 tttctgcttt gcctttaata aaatactgtt gcattagccg ccaatcactc ctgagatatc 8341 atctgttttt ttaaagacaa gggcgttcca ctcaccttga atcatgtgcg tctcaaggaa 8401 gaagcctgcg ctaaaggcag cttccagaac catatccaat ttctcagaaa tgatgcctga 8461 taagataagg taaccttcct ttttgaccaa acggtaagca tcatcagtca acaagactaa 8521 gatatccgcc aagatattgg ctacgatcac atccgcttct tggctaaccc cttttaaaag 8581 gtcgccagca gccacatgaa tgttgtctgt tccttgattc aaatcaatgt tttcttgagc 8641 cactcgaaca gccacgtcat ctaagtcata agcgtagatg gttttagcac ctagtaagga 8701 actggcaatc gagaggacac ctgatccggt ccctacatcg ataactgtct caccaccacg 8761 aaggatttgt tctagagcaa aaaggctcat cttagttgtg ggatgtgtcc ctgtcccaaa 8821 tgccattcca ggatctaact taatcacctt ttccccagca gaagcgtcat aatccgtcca 8881 actagggaca atggttaaat catgcgtgat gcgagctggt tcatagtatt ttttccaatt 8941 gtctgcccag tcttcctcag ctaattcttg actgtccaca gtaacctgac caacctgtaa 9001 cccaaaacta gctaactccg ctaactgttc attaatggtc gcaataacat ccgccaaatt 9061 agtgctactt gggtaatagg ctgtgatagc tatcatgtca gactgctcca catctgggta 9121 taactcccca aagcggtcct tttgcccaat atagtctgcg ctatctgcga tagcaacccc 9181 ttggctgcct gtctcaatca acacatgtga aacagcctct tgcgcatcac gatgcacatg 9241 aaccgtcact tcttgccatg tttccatagt tatgtccttt ctattttgac cttttggtta 9301 ttgtcctaat agtgttagca ccatctcatg tgtcacctta gtaccttggg taagggtaac 9361 ttgctgcttc ttctagtcct tgttgacctt cttcaaaagc ttgcgcattc cattccaagc 9421 cgaaatcagc cttgctgtca tctgctaaga aatccatcaa atcgctgtgc ccttcaatag 9481 caacatcgtt gagaaattgc gcaaagtaag ctaagaattc acgagaaaag ccctttttag 9541 cgtcaaaagg aatagtaacc aaataatctg ctgcatcaaa ttgagacttg gcagggttgt 9601 aaaagagcac atagtcctca aagacaatat catcttgggt cacttcgcca ctatcgtcaa 9661 tggtttttat ggcctcttta ttttgagctt ctaaaacaaa agtcacttca accgcatgat 9721 ttttcttgtc ccaatccata gcataatcat actgaaaatg cttatccatt tcttcttcta 9781 atactgataa aaagccgtat tttgccatct aattgtcctt tttcctaacg attatttgct 9841 tccattgtag cataatttga gctaactttc actggcaaat gctgactgat gggccttctg 9901 tattttagta agcgttttac cccttacttt cctcccatta tgttaaacta ataagcgatt 9961 atgatgttag gagaaaaaga atgagatatt ctagacgcta cccttctcag acaagacaga 10021 tgcttcttgc cttgttatta atgactgtca gcctacaagc tggagctatg actacttatg 10081 cggatgaggt taataccaac catcaaccac taacggccca agtggaagct agtaagccga 10141 cagccatgga atctgtcact tcacctgcag accagaccca tccaatctca acgcaagagg 10201 cttcgtctcc tttacaccct ttaacaacag aggccactcc tgccgcccaa gaatctccga 10261 ttaccttaga agactataag gcagccagtg cgagccaatt agctgagtgg gctcgccagc 10321 aacgggtcac aggccaacag ctgctagatt ttgccttgga aaccatcaaa gaaactaacc 10381 ctgagctcaa taatgtcatt tctctgcgtg aaccattggc tcgacaagag agcgagcaaa 10441 tgacagatga ggggcaaccc ttttacaagg ttcctattct ggttaaaggg ttaggacaca 10501 ccgttgctgg aagtagcaac accaacgggc ttgccttttt gaaagacaaa accagctcat 10561 ctaccagcgc ctttgtcaaa caactccaaa aggctggttt tatcgtggta gggcagtcct 10621 ctttccctga aatgggatgg attaatgtga cgaattccaa tctttacgga aatacacata 10681 acccatggca gcttgaccaa aatcctggcg ggtcctctgg tggctctgca gctgctgtgg 10741 cttcaggaca agtcagtcta gccagtgctt ctgatggtgg gggctcaacc cgcattccag 10801 cttcttggag tggcttgatt ggcctacacc caacacgtgg cattttagag ggaaatccga 10861 cttctgaacg tagcaatgtt agccattttg ctctaactaa gagcatggaa gacactgaaa 10921 agctcttcca attcctctta aaagacaagg ctaaagcgca acaaaaccta cagcgtttag 10981 acacaagtat ccccattgct tacagcaccc agacaccagc tggaacacca attagtgagg 11041 aagctattgc tgcgatcaaa gaagctgtag cctttttaca ggagcaaggt tatcaaaccg 11101 tagaagtgcc ttaccccgtt gatggtaagc tcatgatgca atactattac actattgctg 11161 cttctgcagc gccatctatc aattttatgg cacaacaaac cttgaaacgc ccccttcaaa 11221 aagaggatgt cgaactccta tcatgggcgc tctaccaaac tgggaaagac ttgaccaaag 11281 aggatgtcaa caaagcctgg gaaggtatcg cagccatgac cgagcaatta aaccagttct 11341 accaaaaata ccccatcttc ttaacaccga caacagccta tcccgcccct gctgctgatt 11401 accaccacat tcctaaagac ctagtagcac agctcagtga catgtcaggc ttgagcaaag 11461 aagaaaaatt ggaccttatt taccggcaat ggttacctgc atggacgcta acaccattta 11521 cccagcttgc taacctgacg ggaacaccat ccttgtcctt accaacccat gtgacgaaaa 11581 gcggtctacc tcttggcatt ttggtgaata gcggagctca taacgatagt ctcctgttac 11641 aactgggaca gctctttgaa aaagcaaatc gtttccatat cctgacggct ggcaaaaaag 11701 gattaccaga aacacctaca catgagcata acctctcaac tcaatctgaa aacaagcaag 11761 gcgttgccat tccagtgact tatcaaacca agggatttac tgctggacca accaagggcc 11821 agaacggctt agtaaccctc cctcaaactg gtgatggtca gtcaaaaggt gtgttgttaa 11881 gtagctacat cagccttttc cttggaaccc tcttcttagc aggaagcttc tggagcaata 11941 agttaaaaga ctaggctatt gtcgtcggag atttaaccta cctaaacatt cactgctgct 12001 tgccttacga taagagtata ttgtagtcaa tcaagactga actttcttag tgaaagttca 12061 gtctttttac gtggccaaaa gacagttgtt gcctgttctc attaggctta gcaaccgctt 12121 ttatgatata atttgggtat gcatagaaaa acgattattg atttcaaaga gctcgggcga 12181 cgctatcttt ttgatgagcc attagtagaa ttggtagcca agtccttaga tcaggtcggt 12241 ccagtcattg aaaaagtaca acactaccaa cagctgggct attacgtggt gggctatctc 12301 agttatgaaa cagctgcttt ttttgacaat gccctacaaa cccataataa cagactaggc 12361 aacgagtacc ttgcctattt tacagtgcac aaaacctgtc agaaagaaga cctacctctt 12421 gattatgaca gcattactat ccctaaccaa tgggtcagcg caactcaaaa agaagcctat 12481 caaaaagcca ttgaatccat tcaccgtgag atgcaacagg gcaatactta tcaggttaac 12541 tacactattc aattaactca ggaactcaat gcagctgaca gcttagccat ttacaataaa 12601 ctcgtcgttg aacaggctgc tggctacaat gcctatatcg cccatgatga gtttgccgtt 12661 atttcagcta gtcctgagtt gttctttaaa caggaaggga atcaactcac caccagacct 12721 atgaagggca ccaccaagcg cggggttaac acctggctgg atcaacaaga acatgattgg 12781 ctccaagctg acgggaaaaa tcgctctgaa aacatgatga ttgttgactt gctccgcaat 12841 gacatgggaa aaatttgcca aataggcagt gtttgtgttg ataggctctg tgaggtcgag 12901 cgatactcta ccgtctggca aatgacctca actattgttg gtgacctcaa agcggactgt 12961 gacctgatag acattctcac agctctcttt ccttgtggct ctatcacggg ggctcctaaa 13021 gtctccacca tggcaattat cacatctctg gagccaaaac caagggggat ttattgtgga 13081 agtattggca tttgtttacc tgacggtcgc cgtttcttca atgttcccat tagaaccatc 13141 cagctcagtc ataatcaagc gacctatggt gtcggaggcg gcatcacttg gcaaagcaag 13201 tgggaagacg aatacgagga agtccatcaa aaaacagctt ttctctatcg gcacaaacaa 13261 atctttgacc tcaaaacaac cgccaaggtg aaacaccaaa aaatagcctt ccttgagcaa 13321 cacctcaatc gccttaaaga agcagccact tattttgctt acccttacga tgagaaagct 13381 ttgcagaaac aactagctac ctatttggaa aataaggata atgctgccta ccgcttgatg 13441 attcgtttat ccaaagatgg aaaaattagc ctctctgatc aacccttgga acctttgtca 13501 gccgagtttc tgacagctca actctcttta cagaaaaagg acgtgacagc ttcgcctttt 13561 acctacttta agaccagcta ccggcctcat attgagcaaa aatcttatga acagctattc 13621 tataaccaag cggggcaatt attggaaacg tccattggca atctttttat ccagctgggt 13681 cggaccctct acacaccacc agtggctgtg gggattttac caggactttt tcgccaagag 13741 ctgctagcta ctggtcaagc tcaggaaaaa gaggtgacac tagctgattt aaaagaggct 13801 agcgctattt ttggaggaaa tactgtccgt ggcctctatc ctctcaacct tgagcttact 13861 caccttgatg ccctcttagc taagagtcaa gcctaaactg ccactcatct tttgttatta 13921 aggaacctat gatactctta attgataatt acgattcatt tacctacaac ctctcccaat 13981 atctaagtga atttgacgag acgattgtct tgtataacca agacccaaac ttatatgaca 14041 tggccaaaaa agccgacgcg ctagtcctct cacctggtcc tggttggccc aaggaagcca 14101 accaaatgcc aaaactcatt caagactttt accaaacaaa acctatctta ggagtgtgtc 14161 tgggacacca agcgatcgct gaaactctag gaggaacctt acgcttggca aaacgcgtca 14221 tgcatgggag acaaagcacc attgaaacgc aaggccctgc tagtcttttt cgctccctgc 14281 cacaagagat caccgtcatg cgttaccatt ctatcgttgt ggatcagtta ccaaaaggtt 14341 ttagcgtaac tgctagagac tgtgacgatc aagaaatcat ggcctttgaa caccacaccc 14401 tgccactttt tgggctacaa tttcacccag aaagcatcgg aactcctgat ggcatgacca 14461 tgatcgccaa cttcatcgca gccattcccc gttaatctca tcccccaaaa gaaaggagga 14521 cagttacatg cctgatcatt tagcgctcag aatgcgcccc aaaaccattt cagaggtcat 14581 cggacaaaaa caccttgttg gcgaaggcaa aatcatccgt cgcatggtgg aagcaaatag 14641 actatcgtcc atgatcctct atggccctcc aggaatcggt aaaacttcca ttgcttctgc 14701 tattgctggt actactagat atgcctttcg gacctttaat gccaccattg acagtaaaaa 14761 acgtctccaa gaaattgcgg aagaagctaa attttctggt ggcttggtat tattactaga 14821 cgagattcat cgccttgaca agacaaaaca agattttctt ttacctttac ttgagaatgg 14881 caccattatc atgattggcg caaccactga gaaccccttc ttttcagtga cacccgctat 14941 cagaagcagg gtccagattt ttgaattgga accactttct aacgaggata ttaaaacagc 15001 cattcagcta gcaatttccg acaaagaacg gggatttcct tttttagtga caattgatga 15061 tgaggcgcta gatttcattg ttaccgccac aaatggagac ctacgatctg cttataattc 15121 cttggatcta gcagtcatgt ctacttctcc taatgaagat agtagccgtc atattagtct 15181 agagacaatg gaaaatagtc tgcagcgtag ttatattacc atggataaaa acggggacgg 15241 gcattatgat gttttatctg ccttacaaaa atccattaga ggttctgatg tcaatgctag 15301 cctgcactac gccgctcgtt tagtagaagc tggagacttg cctagtttag caagacgatt 15361 gaccattatt gcttacgaag atattggctt agccaaccct gacgcccaag ttcataccgt 15421 caccgcacta gatgccgctc aacgcattgg ttttccagaa gctcgtattc ttatcgctaa 15481 cgtggtcatt gatttggctc tatctcctaa atcaaattca gcttatttag ctatggatgc 15541 agctttagct gatttgagaa catcaggtaa cctccccatt ccaaggcatc ttagagacgg 15601 gcattatgct ggcagtaagg acctaggcaa tgccaaagat tacctctacc cacacgccta 15661 ccctgaaaaa tgggtcaaac aacaatacct accagataaa ttagtaggac atcattattt 15721 tgaagccaat gaaaccggta aatacgaacg cgcacttggt tcaaataaag agcgtattga 15781 taagctctta gactgactgc tagttttaaa aatcgcaacc gatttcaaaa atcgataatt 15841 ttgcttgaaa aaattttaaa aagtggtatt ataaaagtac agaaacattg ctgtggcata 15901 cgaatccaca tctaagtgtt gaccgactat ttctttgtat tttcgggaaa caaagactct 15961 ttctagtctg caagccgttt cacgcggacg caacttccaa gaaagagcgc gttacccacc 16021 tgcttatact gcgcgggctc aatacaaaaa cgtggatcac cggtgccaat acagcattct 16081 tgcctcctta gctcagttgg tagagcagta gactcttaat ctatgggtca caggttcgag 16141 ccctgtaggg ggtatacaac tatacatgaa aaaacctttg tttaaaggct ttttttgctt 16201 gtcagaagag gatttgttcc atcatttatc cccgcagtaa ttttttatgg tatgatacca 16261 attaaagcgc ttaagattaa ggtggagact gttatgaaaa taattgagta caaaggaaat 16321 tacagagatg acctcatttt tatggtcttg gaagcaaaaa atgccttaag gagaattccc 16381 agcattaacc cggatctttt gacaattgaa acaagttatt tggaaaaagg ggattgtttt 16441 tggctagcgg tcaatgaaga aagtcgtgtt attggctcaa tcgcttattc ttctattccc 16501 aaaacaaatg aggtcttctt gcaccgtctc ttcatcaaac caagcttaaa acatcaaggc 16561 attggcagtc aacttctgac gtttgcagaa gattatctaa ggaaaatcgg caagagtcat 16621 gttcgtatcc acttaggtca acctaaagaa caatggtttg agtcttatcg gttttatcct 16681 aaacatggtt atcaatttta tgatgacacg catctcatca agaaactaat ctaaacacat 16741 ttcataccct ttatagtcat ttcatacgtc atttttagga ggtatccatt gaaaattgcc 16801 atcattggac atagtggctc tggaaagtca accttagcac gatttttagg ccaacattac 16861 cattgtgagg tattccattt agaccaacta cacttctcat cgaactggca agaacggtca 16921 gatcatgaca tgatagctga tttatcaaca tgcctgctca aacaagattg gattattgag 16981 gggaattatg ccaattgtct ctatgaagag cgcatgagtg aagctgatta cattatctat 17041 gttaatttca gtcggtttca ttgtgtctat cgagcattta agcgttattt aaactataga 17101 ggaaaaacgc gtcctgatat ggctgacaac tgtcaggaaa aatttgacgt tgcgtttgtg 17161 aaatggattc tactaggtgg acgttcaaga aaccaattaa aaaaatacca atccgttgtc 17221 caaaaatact ctcataaaac cattgtctta acaaatcaaa agcagctaag tcattatatg 17281 aatacgatca actaattaga gtgcaaaact aaaataacca cgggtaatcc gggctattca 17341 gactgaaagc ctttgtttaa aggctttttt gcttgtttca taactaatcg gattaattaa 17401 aagcgtcaat ccacttttag tatcatgtct caattttcat tcgatagtca gcaagtatat 17461 ctaaaaaatt gttaatgatt atttcttttg aaagtgttat attaaaacat aataaaataa 17521 tagctcctga aaagaggcta tttatgaaaa aaacaaaact tattttttct tttacttcaa 17581 tattcattgc aataatttct cgtcctgtga ttggattaga agtagataat aattcccttc 17641 taaggaatat ctatagtacg attatgtatg aatattcaga tacagtaatt gattttaaaa 17701 ccagtcataa cttagtgact aagaaacttg atgttagaga tgctagagat ttttttatta 17761 actccgaaat ggacgaatat gcagccaatg attttaaaga tggagataaa atagctatgt 17821 tctccgtccc atttgattgg aactacttgt cagaaggaaa agtcatagca tatacctatg 17881 gtggaatgac accctaccaa aaaacttcaa tacctaaaaa tatccctgtt aatttatgga 17941 ttaatggaaa gcagatctct gttccttaca acgaaatatc aactaacaaa acaacagtta 18001 cagctcaaga aattgatcta aaggttagaa aatttttaat agcacaacat caattatatt 18061 cttctggttc tagctacaaa agtggtaaat tagtttttca tacaaatgat aattcagata 18121 aatattctct cgatcttttc tatgtaggat atagagataa agaaagtatt tttaaagtat 18181 acaaagacaa taaatctttc aatatagata aaattgggca tttagatata gaaattgact 18241 cctaattcaa tttttcaata taacttttat acaataagct attccaaata gattgaatcc 18301 tctaaaaagt aagtatgtct ttttttatat cacttaggtt ttgttctaaa tttgttctag 18361 aatgctatac tttctatatt aattttaaaa aacaaaaatt gataaattcc ttgataatac 18421 tagccatttt tgtttataaa ttctctttat tatgcttttt ctacttgtag ggggtatgat 18481 acaaaaatga caaaagcttt tagaacgtag atagacccag tgtgatgctc aaaaagcatg 18541 aactactctg ctaatgtgat acccgatttc ctatttctgc gaacgaagta agccaagacc 18601 aaatcagatg ttttttgctg tggagaaagt cgctgccgcc cgaaccacct caaaaaaagt 18661 atcaaaaaag acttttttca ctattatttt tacctgtatt aatagctatc tgaagttttt 18721 gattcccttc gtaaactaca attcctttat ttcttagtga ccagtttaat tcttttttta 18781 atctaaaata agtcatgaaa cctctttatc ttttgttaat acatcaactt ataaaaaagc 18841 cctgagtatc ttcctgaaaa taacaaaaat tctaattaac cagttaaaca attgccctcc 18901 tatttgttta ttgctataat gagatggagt cgttactatt attattt //