LOCUS NC_003485:6 18393 bp DNA linear BCT 03-OCT-2011 DEFINITION Streptococcus pyogenes MGAS8232, complete genome. ACCESSION NC_003485 SOURCE Streptococcus pyogenes MGAS8232, complete genome. COMMENT locus start: 1041280; locus end: 1059672 FEATURES Location/Qualifiers source 1..18393 /organism="Streptococcus pyogenes MGAS8232, complete genome." gene complement(0..221) /gene="" /locus_tag="" /db_xref="1041280..1041501" CDS complement(0..221) /gene="" /product="hypothetical protein" /translation="MLTYDEFKQAIDDGYIVGDTVMIVRKNGQIFDYVLPHEEARNGE VVTEEKVEEVMVELDYIIMKKTLSRQKNN" gene complement(336..1124) /gene="" /locus_tag="" /db_xref="1041616..1042404" CDS complement(336..1124) /gene="" /product="putative exotoxin precursor (SpeL)" /translation="MRIFLHQNCRLVNMSTTFFIVVLSLMVFSVRMVSAEETINIKDI YSPRWDVDKTLSPTTLREIYNRDTIKKVNKPITGKRGTQVIMDAQHKTKVWEFDDYNF IISSNLHPSVEGKFNVGDNVDVFGLALSAEVFSKDQIHSINGGLVKVNERKGAGKTIY MNVFIDGHKKDDTSKYKITFEKSPVTFQEVDVRLRKSFMLNDEIKLYQYDSKVLSGNW EFHGSGEKEEGADLFKYPDYRYNNLIDIDKKSHIDVYLFTNKEN" gene complement(1406..2119) /gene="" /locus_tag="" /db_xref="1042686..1043399" CDS complement(1406..2119) /gene="" /product="putative exotoxin precursor (SpeM)" /translation="MKKNTLTLLFLVCVSLALYTTESVFSDAVLVNSELKNIYTKDVI NRTNMKITKKIGTQLIFNTNEKTRVWDDDNYNKVISSNVSPAQERRFKEEEVDIYALI KSYSVICKEQYNYVDGGLIRTSDREKLDSTIYMNIFGEQIPLKEQSKYKITFQNKFVT FQEIDVRLRKSLMSDNRIKLYEHNSICKKGYWGIHYKDNTTKFTDLFTHPNYTDNETI DMSKVSHFDVYLNEDFSKN" gene complement(2423..3289) /gene="" /locus_tag="" /db_xref="1043703..1044569" CDS complement(2423..3289) /gene="" /product="hypothetical protein" /translation="MGTIAPAFMELLLDANFCKAPVNNQDTLLKVYHREMAKDNVTIP YEIIAEYVYSHEDSVEENEKLNSNIDFIISEFSGTDTQKDILIKNLDKIKSNYSLAQT QKKFILKNSQEAKDVLEKIIPELKTLAKETSNLAATNDELKKQSAETNGVLQKVKQGV DDVRNTKSSIYTDFIAILGVFSAFVFVMFGGIDVARAIFDIGNDLQTLDLSRMITVSS LMLIGVLTLMYSLLLWVARITGKNFGNCYSSKCDNGCRHKWRHFLMRHSFYFSLMFLL VLTTVVSHCLLK" gene complement(3277..3801) /gene="" /locus_tag="" /db_xref="1044557..1045081" CDS complement(3277..3801) /gene="" /product="hypothetical protein" /translation="MHALFVANYIIEYSNKKGYKINNLKLQKLLYFVNVRNILENGAP LFEESMEKWKYGPVVPDVYHEYKRFGAFSISTDEMIMEYVEFSVSPFGELSDLEITEY DSQKVENTQLIENTVDALHGFGPFELVDITHDHTPWKKYEDRIMDGVQGIKYTIEEIK DFFGHNPGAKIWVQ" gene complement(3941..4426) /gene="" /locus_tag="" /db_xref="1045221..1045706" CDS complement(3941..4426) /gene="" /product="hypothetical protein" /translation="MEVAGSPYGHTGAVIEDSDGYTIKTVEQNIDGNWDSLQVGGPAR FNIRDFTGVIGWIRLPVDHTHQTVDTAPQNSDTIVETAKTGTFTLDVAEINIRRWPSL ASEVVGIYKQGDTVSFDSEGYANGYYWISYVGGLGMRNYLAIGQTDKDGNRISIWGKL N" gene complement(4695..5387) /gene="" /locus_tag="" /db_xref="1045975..1046667" CDS complement(4695..5387) /gene="" /product="hypothetical protein" /translation="MKTTEIKEIGNVFNNLRVISYAGKNKHNKKLAFCECLLCGAKKN MILTEVRTGKSKSCGCLATIKAKERQMVHGYSGTKVHRAWKGMRQRCTNPNYEHYHRY GGRGITFNDEWNDFQIFLNDMGFPPSDRHQLDRIDNDGNYCKENCRWVLPKENCNNRK TYHNKTGFTGVTENTSKKGRYSAVFHVNRKHIQVGTFDSPLEAYRARVNAIKKYNKEH NTNLKYIEVEDL" gene complement(5620..6177) /gene="" /locus_tag="" /db_xref="1046900..1047457" CDS complement(5620..6177) /gene="" /product="hypothetical protein" /translation="MTFLDNIKQGCLDGWTKYKILPSLTAAQAILESGWGKHAPHNAL FGIKADSSWTGKSFDTKTQEEYQPGVVTDIVDRFRAYGSWDESILDHGKFLNDNPRYK AVVGETDYKKACHAIKDAGYATASGYAELLIQIIKENGLQFWDAEVLKSNKEETMTTA NEIVKYCVDLANSGMGVDKDGAYGT" gene complement(6293..6520) /gene="" /locus_tag="" /db_xref="1047573..1047800" CDS complement(6293..6520) /gene="" /product="putative holin" /translation="MINLKLRLQNKVTLMAILGAIFLLAQQLGIKLPSNIADIANTAV TLLVLLGVVTDPTTQGLSDSEQALTYHEPKQ" gene complement(6517..6792) /gene="" /locus_tag="" /db_xref="1047797..1048072" CDS complement(6517..6792) /gene="" /product="hypothetical protein" /translation="MATELIFGVGGFILAIVTTYNIFNAKSIKHATDITLLQSEVEHL KIVTRQNARRLEEHAEQNKTLITMTEQIKNLTDDVKDLKDMMRGEIK" gene complement(6808..7419) /gene="" /locus_tag="" /db_xref="1048088..1048699" CDS complement(6808..7419) /gene="" /product="hypothetical protein" /translation="MRNWKVTGKYPQYDSTGAVASTHIIITAEDGSVISQPIKQDLTS TNDTEIIKATLEEFKKSEYVEIAMGEAVQKVDDLEKISQETANTAKTAQTAAGLAKVS AERTQRMINLQTIHMLTSDGKIDSDIYKGMLELIESAQKGEYQAYDVFTVVDDKHEEQ AGEGNLVFVHVNEPFTYDKQTLKELEEEDKVTVIKYADLVKQD" gene complement(7422..7583) /gene="" /locus_tag="" /db_xref="1048702..1048863" CDS complement(7422..7583) /gene="" /product="hypothetical protein" /translation="MQEKLLGKIINDLALKVANLTLENAQLKAQHEIELEELNAQLDE ATAPKEEGK" gene complement(8264..9496) /gene="" /locus_tag="" /db_xref="1049544..1050776" CDS complement(8264..9496) /gene="" /product="N-terminal fragment of hypothetical phage protein" /translation="MSRDPTLTLDESKLVIGPDGRMHYTFTAQDDNQKVRLVSNCLGT AHFNQVMIERGDKATSYVAPAVVEGSGKSTGVFKSFEEMLSSLKSINLELTDTKNSKL WSKIKLTNHGMIQEYYDGKIKTEIVNSAQGVATRITEDTGKKLALINDTINGIKREYQ NADKKLSASYQLGIDGLKATMRSDKIGLQAEIQTTAQGLYQRYYNEIRKLSAKITTTS SGTTEAYESKLDGLRAEFTHSNQGMRVELESKISGLQSTQQATARQISQEISNREGAV SRVQQGLDSYQRRLQSAEGNYNSLRETVAGYERRISNQDNTISSNFTQLKSLINQSVT LGKIQSLLRQSGDSIMLAIKDKIPQSKMSGSDIISAINLNSRGVQIAGKNIALDGNTT VNGAFGAKLGEFIKLRAD" gene complement(9511..10509) /gene="hylP" /locus_tag="hylP" /db_xref="1050791..1051789" CDS complement(9511..10509) /gene="hylP" /product="hyaluronidase" /translation="MTETIPLRVQFKRMTAKEWASSAVILLEGEIGFETDTGYAKFGD GKSRFSELKYLNKPDLGAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLSL TGGIVTGQLRLKPNSGIEKSSSTGGAINIDMSKSKGAAMVMYTNKDTTDGPLMILRSN KDTFDQSVQFVDYRGKTNAVNIVMRQPSTPNFSSALNITSANEGGSAMQLRGSEEALG TLKITHENPSLEANYDKNAAALSIDIVKKTNGAGTAAQGIYINSTSGTTGKLLRIRNK NKDKFYVNPDGGFHSYADSIVDGNLTVKNPTSNEHAATKKYVDEKIAELKKLIPKK" gene complement(10506..12557) /gene="" /locus_tag="" /db_xref="1051786..1053837" CDS complement(10506..12557) /gene="" /product="hypothetical protein" /translation="MIYLFDKLERLIATVGTDDLLSWHFKVKNNDWDQANFEVPIDYD IEPFVYFGFFHKVPDEERDVFKLFKVIDYNLEDSKFYKGLDKAESDLDTIAIIKDKRF RQSSADACLDGALVDTGYQVGKVEGISGVRTLSYYYISPRAALVKVVEAFNCEFNVRY TFVNNKITSRYIDLKKRFGKPTGKQFEHGNNLLKVVYEESTDDIVTCLIGRGKGEEIQ HEETEPKEVEGHLPQEERRQGYGRRIEFTDVVWSVEKGDPIDKPAGQNFVALDSAREE YGLSQNGELKHRWGVFVNEEIEDKTELLKATWDELQRLSIPIRIYKAEILDIGPETWK GDSVAIIYDEVKIAFETRVDEIDIDKLNFNRSVVTLGDYSVVQNREAMSRKEAVQNMI DESLETITGLGMTFQEFLQDIEKRIETGKKEMEDNWRKVNLEFDNFKKKVEQEGLQFN TLKEQIKEVDERIDKELEEFRATLKNLALPEEAIKKITEAIKVDDIPSIKQSFDDLKN KVSETSETSRLNAEILGNNGKTRYNKNLLVGDPNRVKKIDEGFIELEANDGGFKRGET YTISFSQTCELLQKVAITLTQANNKGVKLVLTPTKAKMEPETFTLIKDTEVINVYPLS YSATLSGTWYKSKQIDLNASEVQNMALEMSYKEVVDGKDAAITGTWSDSPQIILDGGK K" gene complement(12554..13333) /gene="" /locus_tag="" /db_xref="1053834..1054613" CDS complement(12554..13333) /gene="" /product="hypothetical protein" /translation="MYEFNDTIRGTPKESFSIKTTIDGKVLEDELNKDFGTFRTLTVS GRDIVDLEHQTTSVLGRNGEYFHNATVEVRKLEIKAKISGKNNQSMRLQYEKLNRLIV SHNQVFLSFSDEPDRNYLGIFKSKDVPEEVSNEQIIGLTFICYNPFKMSDVKTKKGTS IQNGGLFETKPIITLKLSSPTKEIKLLHVKSQKYIRLTGTYTTDEIKIDMATGKITQN GRNILSDLDMVNSRYFELLPGKNTLQCDNATITAEFREVYL" gene complement(13365..15647) /gene="" /locus_tag="" /db_xref="1054645..1056927" CDS complement(13365..15647) /gene="" /product="putative minor tail protein" /translation="VALLAKSSAAWVISLSLLVQPYQQLQKVSELVLKLLCLESPPII SSLGTAISTVAQGIGTGLAIAFKGLGAAIAMVPPTTWLALGAAVLMVGAAFALAGTQA DGISQILRTVGDVVVQILQQVTDSLATLLPIIANAIGSMLPIVAGAISQIVGAVAGGL SQLVIAVSTGASLVIGAFTGLLGGISGVINSISAVIQSLTGVITAVFNGIATVISSVG SAIKDVLTGLGIAFEGFGNGVKSALEGVGAVIESFGSAVRNVLDGVANILDSMGTAAL NAGRGVKEMAKGIKMLVDLSLGDLVATLAAVASGLGKMASSAGEMTTLGSAMSKVANG MTRLATSATIAITGLTVFATTMATIKTAVATLPPVLTMAASGFTTFTTQAVAAVTGLA AINAPITMFKAQLMAITPALAQAGAGFAAFVAQSSTFSTGLASAGPTIAAFNANLMSL SATTGALVASIVGLSAVLSVVLADFSQIGASATATVGQIQAFASSTTVVSSAFASMQS MIQSAMAAIVSSIITSFNQAASQMQSILSRMLSQARTFGSQLEQQMRQSGQRSGQNLA RGLSSQQSAVINAISSMVNAAVSRANAGAGPMRQAGAYIGQGLAQGMYSALGAVTAAA NALVAQAERAARAKAMIHSPSRLFAKRVGQYIPQGVAMGIDKNADVVDDSVGGLFDSI NSFDFNIADRLASIGAKFQGVVKSESSQSLSQQQEFVHTAQPAYINFSLGGNEYEAFV SDITSQQAKIEKIRLKRSSW" gene complement(15514..17001) /gene="" /locus_tag="" /db_xref="1056794..1058281" CDS complement(15514..17001) /gene="" /product="putative minor tail protein" /translation="MGESYSVEAVLTAVDKTFGKTLQSAIRSIEGLEKRSTGFSSVSQ KASSMFKSMLGANLAGQAISAMTRTVSSGLGSMLGEMNSSAKAWKTFDANLADIGFGK KQILAVKTAMQDYATKTIYSASDMASTYAQLAAVGVKDTGKLVKAFGGLAASAENPKQ AMKSISQQMTQAVGRPTVAWQDFRIMLEQTPAGMAKVAKSMGKNLDELVADIQAGRVK TSDFLEAVKKAGNDKSFQKMATEFKTVDQAIDGMREGLSNKLQPAFEKVNQFGIRAIE AIGKQLDKVDFSKFASNLGKFLEGINIDKIVSNISSAVSSVTSKVKEFWDGFKQTGAI SAFSGALQSVWGALKNVASAMSGGNWKTFGATVGGIVKHVSNFAKAVSDVLGKMDPGR LRSWIATFAAVAGGFKLFEKLTGQSVIGSFLDKIGSKFGLFGNKAKEGTDKASNGARR SGGIISQIFSGLGNIVKSAGTAISTAAKGIGVGIKTALSGIPPYH" gene complement(17016..17345) /gene="" /locus_tag="" /db_xref="1058296..1058625" CDS complement(17016..17345) /gene="" /product="hypothetical protein" /translation="MIVLNCIRYLGMTDINEIGRLTLYEYDLLMTGKALAAVDESHKA HKQAWINYQVTATKLVGGKKNKKEVPVYKKFKDFFDYEEEIRKITQEIDEGYDKKGMD LLLKANL" gene complement(17375..17734) /gene="" /locus_tag="" /db_xref="1058655..1059014" CDS complement(17375..17734) /gene="" /product="hypothetical protein" /translation="MQLEIKGKTHNVKFGTRFVAEMDKAHVTEREGMKFGTGLQSTVP FLFERNVVTLAEIIHVGTITESPRPSLNDIYDYIDEVEDIEKLFNDVLDELRQSNASK LFIAKLDKNMAEMEAEA" gene complement(17787..18392) /gene="" /locus_tag="" /db_xref="1059067..1059672" CDS complement(17787..18392) /gene="" /product="putative structural phage protein" /translation="MSEAQEQTKQLEAKQGIHSILLFRLLKEASSEVATKLAFQTEHE VGKSRDVDGQKTKDGIIQSVGALEYDFKATSILAKGDTLAAKLEKAMEDGELVEIWDI DSEEASKKNDENGIAKVWDIKNGTNGGENKYLATYYQGYISSFSAKKNAEENIVIEME FAINGVGKKGLATLTNDQKKAVQYAFKDTTSETKKENSFEM" ORIGIN 1 tcaattattt ttctgtctac tcaaagtttt cttcattatg atatagtcta attccaccat 61 cacttcttcc accttctcct ctgtcacaac ttctccattt ctcgcttcct catgcggcaa 121 cacataatca aaaatctgtc cgtttttacg cacgatcata actgtgtctc ctacgatata 181 tccgtcatca atagcttgct taaattcgtc gtatgttagc ataaagcacc tcctatttat 241 ttattcgtaa aaagtctggt atattggaca catttatatg taccgaacaa aaaacgccct 301 caattaagag ggtattcctt ggtttcttga tactaattaa ttttctttgt ttgtgaataa 361 atagacatca atatgactct ttttgtctat atctatcaaa ttattatatc tataatctgg 421 gtatttaaat aagtcagcac cttcctcttt ctcgcctgag ccgtgaaatt cccagtttcc 481 agatagaact ttggaatcat actgataaag ttttatttca tcgttcagca taaatgattt 541 tctcaatcta acatcaactt cctggaaggt aacgggagat ttttcaaaag ttattttata 601 tttcgaggta tcatcttttt tatgcccatc aataaaaacg ttcatgtaaa tcgtttttcc 661 ggctcctttt ctctcattaa ctttaacgag accaccattg attgaatgta tttgatcttt 721 tgaaaatact tcagctgata atgcaagacc aaaaacatcg acattatctc caacattaaa 781 tttaccttct acagatgggt gtaggttact tgatattata aaattataat catcaaattc 841 ccatacttta gttttatgct gagcatccat aataacttgc gtccctcttt ttccagtaat 901 gggtttattc acttttttta tagtatctct attataaatt tctcttaagg tagtagggga 961 taatgtttta tctacatccc accttggaga gtatatatcc ttaatattaa tagtctcttc 1021 cgcagaaacc atcctaacag aaaataccat caatgacaat actactataa aaaaagtagt 1081 tgacatatta accaaacgac aattctggtg taaaaaaatt ctcatttatc ttatattctc 1141 cttaataaat caatatagct attaaactat gtttttggaa cttgaacctc aaaatgctta 1201 aatcggaagt gcttgagcag aattcttaaa agacaataaa ctgaattcta taacgcacag 1261 aaatcaatct gagcggtttt ataatattcc tcggttaacc gacttttgac tgatagtgac 1321 aagctgctct aagtctacta aaaccgtcta attcataaaa atctatttaa atagactaaa 1381 aattaaatta agatagcatt caaccactaa tttttagaaa aatcttcgtt taagtaaaca 1441 tcaaagtgac ttactttact catatcaatc gtttcattat ctgtatagtt aggatgagtg 1501 aataaatcgg taaactttgt tgtattatct ttataatgaa ttccccaata ccctttttta 1561 caaattgagt tatgttcata taactttatt ctattatcgc tcatcaaact tttcctaagt 1621 ctaacatcaa tttcttgaaa agttacaaac ttattctgaa atgtgatttt atattttgat 1681 tgctctttta gcggtatctg ttccccaaaa atattcatat atattgttga atcaagtttc 1741 tctctgtcac ttgttcttat caaacctcca tcaacataat tatattgttc cttacatatc 1801 acactgtagg attttattag agcataaata tcaacttctt cttccttaaa gcgtctttct 1861 tgcgctggag aaacattgct agatataact ttattataat tatcatcgtc ccagactcta 1921 gttttttcat tcgtgttaaa tattaactgg gtgccaattt tctttgttat cttcatattg 1981 gttctattaa ttacatcttt cgtatagata ttttttaatt cgctattaac caacacagca 2041 tctgaaaaga cactctcagt agtgtataga gcaagcgata cacacacaag gaataacaaa 2101 gtcaaggtat tttttttcat tttttctcct aacatttttt aagtttaatc aatttgctta 2161 gcaagtatac tatatttaaa taataattca actataattt taaaaaaaca caaaaaaaac 2221 attatacagc tataaagctt aatataatag gattttatgt atacaattat ttaacagcat 2281 ctattcaaga tagcctactt catcaggttg gtatgactaa gtttttaact tatcttcccc 2341 cctttttttg ttttagaaga taaaagaatt ttcttgattt tgcacacaaa aaaccgccct 2401 caactaagag agcggttggt tttttattta aggagacagt gactaactac agttgttaaa 2461 acaagtaaga acattaaaga aaaataaaat gaatgtctca tgagaaaatg acgccattta 2521 tgccgacacc cattatcaca ttttgacgaa tagcagttac caaaattttt acctgtaatt 2581 ctagctaccc acagcaataa agaatacatc aatgtcaata caccgattag cattagactt 2641 gagacagtaa tcatccttga taaatcaaga gtctgaagat cattaccaat gtcaaatatc 2701 gcccttgcta catctatacc accaaacata acaaaaacaa aagctgaaaa cactcctaag 2761 atagcaataa agtctgtgta gattgaagat tttgtattcc gaacatcatc cactccttgc 2821 ttaacttttt gcaaaacacc gttagtctct gcggattgtt tttttaattc gtcatttgta 2881 gctgcaaggt tagaagtttc ttttgctaat gtttttagct cagggataat cttctccaga 2941 acatctttag cttcttgaga gtttttaagt ataaattttt tctgagtttg agctaatgaa 3001 taattgcttt ttattttatc gaggtttttt atcaaaatat ctttttgtgt atcagtccct 3061 gaaaattccg aaataataaa gtcgatattt gagtttaatt tctcattttc ttcaacgcta 3121 tcttcgtgac tatacacata ttcagcaatt atttcataag gaattgtgac attatcttta 3181 gccatttccc tatgataaac ctttaataaa gtgtcttgat tatttactgg tgctttgcaa 3241 aaattagcat ctagtaataa ttccataaac gctggagcta ttgtacccat attttagccc 3301 ctggattatg tccaaaaaag tcttttattt cttcgattgt atatttaatt ccttggacac 3361 cgtccattat tctatcctca tactttttcc aaggtgtatg gtcatgagta atatcaacaa 3421 gttcgaacgg accgaaccca tgcagagcat caactgtatt ctcaatcaat tgagtattct 3481 ctactttttg tgagtcatat tcagttatct ctaggtcaga taactccccg aatgggctga 3541 cgctgaattc aacatattcc ataatcatct cgtctgtaga aatggaaaaa gctccaaaac 3601 gtttatattc atgatagaca tcaggaacaa ccggtccata cttccacttt tccatactct 3661 cttcaaaaag cggagctcca ttttcaagaa tgtttcttac attaacgaag tataataatt 3721 tttgcaattt aaggttatta attttgtagc cttttttatt tgaatactca attatataat 3781 ttgcaacaaa taatgcatgc atctcaatta cacctccttt ttcttaatta taacatattt 3841 gtcaagtact atatcttgtt agctaaaaag ttagctaaca ctacatcttg attaggatac 3901 caaaaaacag cccccgcaaa aagcgagggc gtttgtctta tctaatttaa tttaccccaa 3961 atactgatgc ggttcccgtc tttatcagtc tgtccaatag ctaggtagtt acgcatacct 4021 aagcctccaa catagctaat ccaataatag ccattagcgt agccctcgct atcaaagctg 4081 acagtatcac cttgcttgta gatacctaca acctcgctgg ctagacttgg ccaacgccta 4141 atattaatct ctgcgacatc aagggtaaag gtgcctgttt ttgctgtctc tacgatagtg 4201 tccgagtttt gtggtgctgt atctactgtc tggtgagtgt gatcaactgg caatctaatc 4261 cagccaataa cgccagtaaa gtcgcggata ttaaagcgag cgggtccgcc tacctgcaga 4321 ctatcccagt taccgtcaat attttgctca acagttttaa tcgtatagcc atcactatcc 4381 tcgatgacag ctcctgtatg tccgtaggga ctaccagcta cctccatgac aaaaaggtca 4441 ctagctttgg gattgactcc aggggcatta tatatgacct ctagcccttg cgcagatgcg 4501 ctatttaaca ggtctatggc attaccccat aaatcaatgc cgaaccagtt tttgacgata 4561 aaacatggta agtcagcaca ctgcattatc ctttaattat aagcctctcc gtaatttcat 4621 ttctgaaaat acttgtatag cttataacac tctttcgagc tcttgctttc acaagagatg 4681 agactatatc ttcaatcata aatcttctac ttctatatat tttaaattgg tgttatgctc 4741 tttattatat ttttttatag cgttaactct agctctgtaa gcttctagcg gactgtcaaa 4801 agtcccaact tggatgtgtt tacgattaac atgaaacact gcagaataac gccctttttt 4861 agaagtgttt tctgtgactc cggtaaaacc tgtcttattg tggtaggttt tacgattgtt 4921 gcaattctct ttaggtagaa cccaacggca gttttcttta caataatttc cgtcgttatc 4981 aatcctatca agctgatgtc tgtcacttgg cggaaaaccc atatcgttca aaaatatttg 5041 aaaatcattc cactcatcgt taaacgtaat ccctcgacca ccatatctat ggtagtgttc 5101 gtaatttgga ttcgtacacc tttgacgcat ccctttccag gctctatgca cctttgttcc 5161 gctataccca tgtaccatct ggcgctcttt ggcttttatc gtagctagac atccgcatga 5221 tttgcttttt ccagtcctaa cttctgtcaa aatcatattt ttcttagctc cacatagtaa 5281 acactcacaa aaagctagct ttttattgtg tttgtttttt cctgcgtagc taattactct 5341 caagttatta aaaacatttc caatttcttt tatttcagta gtcttcatag gttaaacctc 5401 aaatttcatc taacctatta tatcataatt gccccgtgct gtcttgcgat tgcaagcact 5461 tagtcgttga agcttcctct actgttacca tagaggctcg cctgctgatt tcccaatcat 5521 tgtaattttt taaccgtcac gctctctgtt gccagacacg ttgtggctta caatgctcta 5581 agggagtccc agcaattctc ggggttagga acccaattta ctaagttcca taagcaccat 5641 ctttatcaac tcccatgcct gaattggcaa ggtcgacaca gtattttaca atctcatttg 5701 cggttgtcat tgtttcctcc ttattacttt ttaagacttc ggcatcccaa aactgcaagc 5761 cattctcctt gataatttgg ataagtagct ccgcatatcc actcgcagta gcataccctg 5821 catctttaat agcatggcaa gcctttttat agtcagtctc accaacgact gccttatagc 5881 gtggattgtc gtttaaaaat ttgccgtgat caagaattga ctcatcccaa ctaccgtaag 5941 ccctaaagcg gtctacaata tccgtcacaa ctcctggttg atactcctct tgcgtcttag 6001 tatcaaatga cttaccagtc caagagctat cagccttaat cccaaataaa gcgttatgtg 6061 gggcatgttt gccccaaccg ctctctaaga ttgcttgtgc tgcggtcaag gatggcaaga 6121 ttttgtactt agtccagcca tctaagcagc cttgcttaat gttatctaaa aaggtcatct 6181 gtcctcctca tccaaaaacg gataaaagat aagagcaacc acagacatcg gcacatacag 6241 tattgcgatt gctagtatta acgctaatcg tgtgattgct cgcatgtccc ctcctattgt 6301 tttggttcgt ggtaagtcaa tgcttgctca ctgtctgaca ggccttgtgt ggttggatct 6361 gtgacaacac cgagcaatac taaaagcgtc acagctgtgt tagcaatatc cgcaatattg 6421 gatggtagtt taatacctaa ttgctgtgcc agtaaaaaga tagctcccaa aatagccatc 6481 aaagttactt tgttttgtag tcgtaatttt aaattgatca tttgatttct cctctcatca 6541 tatcttttaa atctttaaca tcatctgtta aatttttaat ttgctctgtc attgtaatca 6601 acgttttatt ttgctcagcg tgctcttcaa gccgccgagc attttggcgt gtaacaattt 6661 ttaaatgctc tacctcagac tgcaacaatg taatatctgt cgcatgcttg atagattttg 6721 cattaaaaat attgtaagtc gtgacgatag ctaaaataaa gccaccaacg ccaaaaatca 6781 gctctgttgc cataaaacac ctctacctct aatcttgctt aactaagtcc gcatatttga 6841 tgactgtaac tttatcctct tcctctaact ctttaagtgt ctgtttgtcg taagtaaatg 6901 gctcgttgac atgtacaaag acaagattgc cttcgcctgc ttgctcttcg tgtttatcgt 6961 ctaccaccgt aaagacatca tacgcttgat actcaccttt ttgggctgac tcgattagct 7021 caagcatgcc tttataaatg tcagaatcaa tcttgccgtc gctcgttaac atgtggatgg 7081 tttgcaagtt aatcattcgc tgtgtacgct ctgcggacac cttagctaat cctgcagctg 7141 tttgagcagt tttggcagta ttagcagttt cctgtgagat tttttctaag tcatccactt 7201 tttgcacggc ttcgcccata gcgatttcga cgtattcaga ttttttaaat tcttccaaag 7261 tagctttgat aatctctgtg tcattagttg aggttaagtc ctgcttgatt ggctgagaga 7321 tgactgagcc atcctcagca gtgataataa tatgtgtgct tgcgactgct cctgtgctgt 7381 catattgtgg gtattttcct gttactttcc aatttctcat gtttatttac cttcttcctt 7441 cggtgctgtt gcttcatcca attgtgcgtt tagttcttcc aattcgattt catgctgtgc 7501 ttttaattga gcattttcta gcgttaaatt agcaacttta agtgctaaat cgttaataat 7561 tttacctaat aatttttctt gcattgtttc tcctaaattc cagtcatata attgctatgc 7621 tcgttcatga tagcgctagt aaaattcggg tgtgtagtat cccagccaac attttgtaga 7681 tgtttccagc accttgccaa agctacaatc gcataataca ttttattgat atccacaagt 7741 gtgtttacac ccgttggtgt cattttaaat ccacggttta taccaaaatc atccgcaaaa 7801 atgatggtat ctccataaat ttctgcctga tcaactgatg ctgtatgttc atatccgcta 7861 gccgtccgga aaaaccttgc tccacaaaaa cgaccagatg acgcgctatt gataccatca 7921 ccagatgaag tgattccgat tgacgcataa agagccgacc ttgtaaagtt ttttggtgtc 7981 gcattactaa aatgcacaaa agcagtgtgg gtacctgatt ttcgaacaag cgcattattg 8041 ttgctgttga aattgatgga tgcatcgcta ttaaaatcga tggtagagtt gtttaaatca 8101 atcatcatag caccatttct tgctctgata actttaccct caagcaaatc agtgatagca 8161 tagctaattc ttgccttgat aaaattggca tctaaaccaa caatactgct agctttgaga 8221 ttaatcacat tgattttgtt tgcatcgatt gtcccaccga taatctagtc ggctcttagc 8281 ttgataaact cccctaactt agccccaaaa gctccattaa ccgtcgtatt gccatcaaga 8341 gcgatgtttt taccagctat ttgcacaccg cgggaattca agttaatcgc tgagataata 8401 tcgctgccag acattttact ttgcgggatt ttgtctttaa tcgcaagcat gatactgtcg 8461 ccagattgcc gcaagaggga ctggattttt cctaaggtca cagactgatt tatcaagctt 8521 tttagctgtg taaagttaga ggagatagtg ttatcctgat tggatatcct gcgctcataa 8581 cccgctacag tctctctcaa actgttgtaa ttaccctctg cggactgtaa tcgtcgttga 8641 taactgtcta ggccctgttg tacacgactg acagcacctt cacggttact tatctcttgt 8701 gagatttgcc tggcagttgc ttgttgcgtt gattgcaacc cactgatttt tgactccagc 8761 tctacgcgca taccttgatt actatgagta aactcagctc gtaagccatc gagcttgctt 8821 tcataggcct ctgtagtgcc tgacgaggta gtggttattt tagcggacag cttgcgtatc 8881 tcgttataat acctttgata caagccttga gcggttgttt gtatctcagc ttgtaagccg 8941 attttatcac tacgcatggt ggctttgaga ccatctatgc ccagctgata gctagctgat 9001 agctttttat cagcattttg atactctcgc tttataccgt tgatagtgtc attgataagt 9061 gctagctttt tgccagtgtc ctctgtgata cgagtagcca caccttgtgc ggagttgact 9121 atctcagtct tgatcttacc gtcatagtac tcctgtatca tgccatggtt agtcaacttg 9181 atttttgacc aaagcttaga gtttttggtg tctgtcagct ctaaattaat agatttcaag 9241 ctactaagca tctcctcaaa gcttttaaag acgcctgttg acttaccact accctcaacg 9301 accgctgggg caacatagct agtggcttta tcccctcgct caatcatgac ttgattaaag 9361 tgagctgtcc ctagacagtt gctgactagt ctgactttct ggttatcatc ttgtgcagta 9421 aacgtgtagt gcatacgacc atctggtcct atgacgagtt ttgactcgtc taatgttagt 9481 gttgggtctc tactcattta tcctccttaa tctatttttt tggtatgagt ttttttaact 9541 cagcaatttt ttcatctacg tattttttag tcgcagcatg ttcgttagat gttggatttt 9601 taactgttag attaccatcc acgattgaat ctgcatatga gtgaaagcca ccatctggat 9661 ttacataaaa tttgtcttta tttttatttc taatcctaag caacttccct gtcgtgcctg 9721 aggttgagtt aatgtagatt ccctgagcag ctgttcctgc accgtttgtc tttttgacaa 9781 tatcaatgga taacgctgcc gcatttttat cataattcgc ttcaagactt gggttctcat 9841 gagtaatttt tagcgttcct agcgcttctt ctgaccctcg tagctgcatc gcactaccgc 9901 cttcattggc actagttata ttaagtgccg aggaaaaatt aggtgtgctt ggctggcgca 9961 ttacaatatt tacagcatta gtcttacctc tgtaatccac aaattgaact gactgatcaa 10021 acgtatcttt gttagaacgt aaaatcatca atggtccatc agtagtatct ttatttgtat 10081 acatcaccat agcagcacct ttcgatttag acatatcaat gttaatcgct cctcctgtag 10141 aagatgactt ctcaatacca ctattaggtt taagccgtag ttgtcctgtc actatgccac 10201 ctgtcaaact caattttttg tctagctcta ttttggactc tgcttttaag taaacagcgt 10261 ttttatctgc tttgcttgat tctaatttgg tgattttact attagtttct tctttttgtg 10321 caaacgcacc tagatctggt ttattaaggt acttaagctc actaaatcgg cttttaccat 10381 caccaaactt agcatatcct gtgtcggtct caaagcctat ctcaccctca agtaagatga 10441 cagcactgct agcccattct ttggcagtca tccgcttaaa ttggactcgt agcggtatag 10501 tttctgtcat tttttacctc catctaaaat tatttgtggg ctgtctgacc atgtccctgt 10561 gattgcggca tccttaccat ccacaacctc tttataagac atctctagag ccatattttg 10621 cacctctgac gcatttaaat ctatttgctt agatttatac caagtaccgc ttaaagtagc 10681 tgagtagctc aaaggataga cgttgatgac ctctgtgtcc ttaattagag taaaagtctc 10741 aggctccatt tttgccttag taggtgtcag taccagttta actcccttat tattagcttg 10801 ggtcagcgtg atagccactt tttggagcag ctcgcaagtc tggctaaagc taatcgtata 10861 ggtctcgcca cgcttaaatc cgccgtcatt agcttcaagc tcgataaagc cctcatcaat 10921 ttttttaaca cggttagggt cgccaaccag caaatttttg ttgtagcggg tcttaccgtt 10981 gttacctaaa atttcggcgt ttagacggga cgtctcgctc gtttcactga ctttgttttt 11041 taggtcatca aagctttgtt taatagacgg gatgtcatca actttgatag cctcggtgat 11101 ttttttaatc gcttcctctg gtaacgctag gtttttgagg gtggctcgga attcctctag 11161 ctctttatcg atgcgttcat caacttcttt gatttgttct ttcaaggtgt tgaattgcaa 11221 gccttcttgc tcaaccttct ttttaaagtt atcaaattca aggttaactt tgcgccaatt 11281 gtcttccatc tcctttttgc cagtctcgat gcgtttttcg atgtcttgca aaaattcctg 11341 aaatgtcatc cctaagcctg tgatagtctc taaagattca tctatcatgt tttggacagc 11401 ctctttgcgt gacattgctt cacgattttg gacgacgctg taatcaccaa gagttacgac 11461 tgacctgtta aaattaagct tatcaatatc aatctcatca acacgagttt caaaagctat 11521 ctttacctca tcatagataa tggctaccga gtcgcctttc cacgtctctg ggccaatgtc 11581 taaaatttct gctttgtaaa tcctaatggg gattgacaaa cgctgcaatt catcccatgt 11641 ggcttttaag agttctgtct tatcttcgat ttcctcattg acaaagacac cccagcggtg 11701 ttttagctca ccattttgag acaagccgta ttcttccctt gcactatcta gtgctacaaa 11761 gttttgacca gctggtttgt ctatcgggtc gcctttttcg accgaccaga caacatcagt 11821 aaattcgatt cttcgaccgt agccttgccg cctttcttcc tgtggcaagt gtccctcgac 11881 ctctttaggt tcagtttctt cgtgttgaat ttcttcgcct tttcctcgcc cgatcaagca 11941 ggtcacaatg tcatctgttg attcctcgta gacgactttt aggagattgt taccatgttc 12001 aaattgcttg cccgttggct tgccaaagcg ctttttaagg tcgatatagc gactagtgat 12061 tttgttatta acaaaggtgt atctaacgtt aaattcgcag ttaaaagctt ctacaacctt 12121 aaccagagcc gctcgtggac tgatgtagta ataactaagt gttctaaccc cagaaattcc 12181 ttcaacttta ccaacttggt aacctgtgtc cactaaagca ccatcaagac aagcatctgc 12241 ggatgattgt ctaaagcgct tgtctttgat aatggcaatg gtgtcaaggt cactctcagc 12301 tttgtctagg cctttgtaaa acttgctatc ttcaagatta taatcaataa ccttgaagag 12361 tttaaagacg tctctttcct cgtctgggac tttgtgaaaa aaaccaaagt aaacaaaagg 12421 ctcgatgtca tagtcaattg gcacttcaaa attagcttgg tcccaatcat tgtttttgac 12481 cttaaaatgc cacgagagca aatcgtcagt accaacagta gcgatcaatc gctccagttt 12541 atcaaagaga taaatcatag ataaacctcc ctaaactcag ccgtaatggt cgcattgtca 12601 cactgcaaag tatttttacc aggtagtagc tcaaaatagc gactgttaac catatctaaa 12661 tcgctaagga tattgcgtcc gttctgggta atcttacccg tggccatatc aatcttgatt 12721 tcgtcagtag tataagtacc agtcagtctg atatactttt ggcttttgac atgtagcagc 12781 ttaatttctt ttgttggtga tgatagtttg agagtaatga taggttttgt ttcaaataac 12841 ccaccatttt ggatagatgt tcctttttta gtttttacat cagacatttt aaacggattg 12901 tagcagatga atgttagtcc tataatctgc tcgttagaaa cttcttctgg gacatcttta 12961 gatttaaaga tgcctagata atttctatca ggttcgtctg aaaatgataa aaaaacttga 13021 ttgtgactaa caattaatct gtttaatttt tcatattgta aacgcattga ctgattattt 13081 tttccactga ttttagcttt tatttctagt tttctgactt caactgtggc attgtggaaa 13141 tactctccgt ttcgtcctaa cacacttgtt gtttgatgct ctaaatcgac aatatcacgg 13201 cctgaaacgg ttaaagttcg aaaagtaccg aaatccttat tgagttcatc ttctaagact 13261 ttaccgtcaa tagtcgtttt tatactaaag gattcctttg gagtacctct gatagtatcg 13321 ttaaattcgt acattctacc tctcctaaaa accaaagaga agcaactacc agctacttct 13381 cttcaatctg attttttcaa tttttgcttg ttgactagtg atgtcactta caaatgcttc 13441 gtattcgttt ccgcctaaac taaagttgat atatgctggt tgagctgtat gtacaaactc 13501 ttgttgctgc gataacgatt gcgaactctc tgatttgaca acaccttgga atttagctcc 13561 aatgctagct aatctatctg cgatattaaa atcaaaacta ttgatgctat caaataaccc 13621 gccaacagag tcgtcaacga catcagcgtt tttgtcgata cccatagcta ccccttgcgg 13681 gatatattga ccaactcgtt ttgcaaacaa ccttgacggc gaatgaatca tcgccttggc 13741 tcttgctgct ctctcagctt gtgctacaag ggcgtttgct gcagctgtta cagctcctag 13801 cgctgaatac attccttgcg caagcccttg tccgatgtac gctccagctt gacgcatagg 13861 accagctccc gcgttggctc ttgataccgc agcgttaacc atgctagaaa tagcattaat 13921 aacagcactt tgttgagaag atagtccccg agcaagattt tgtcctgaac gctgtcccga 13981 ttgtctcatt tgttgctcta gttgagaccc aaatgtccta gcctgagata gcattcgaga 14041 taagattgat tgcatttgag aggccgcttg attaaatgat gttataatgc tgcttactat 14101 tgcggccatg gcagattgaa tcatagattg catgctagca aatgctgacg aaacaactgt 14161 tgtactagaa gcaaaagctt gtatttgacc aacagttgct gtcgcagaag cccctatttg 14221 gctaaagtca gctaatacaa cagaaagcac agctgataaa ccaactattg atgcaactag 14281 cgctcctgtt gttgcagata agctcatcaa attagcattg aatgctgcta ttgtaggacc 14341 ggcagatgct aaacctgtac taaatgttga tgattgagca acaaacgcgg caaagccagc 14401 gccagcttgt gctagagctg gtgttattgc cattagttga gctttaaaca tagtgattgg 14461 agcattaatt gcagccaatc cagtcactgc tgccaccgcc tgagtagtaa atgtggtaaa 14521 cccactcgct gccatcgtta ggactggcgg tagagttgca actgctgtct taatagttgc 14581 catggtggtg gcaaagactg ttaatccagt aattgctatc gtagcacttg ttgctagacg 14641 tgtcatacca ttggctacct tgctcatagc agaacctaat gttgtcattt cgccagctga 14701 gctagccatc ttccctagac cgcttgccac agctgctaat gtagcaacca aatctccaag 14761 ggataaatca acaagcattt taatgccttt agccatctct tttacgccac ggcctgcatt 14821 aagtgccgca gtacccatag aatcaaggat atttgcaaca ccgtcaagga cattcctaac 14881 tgcactacca aacgattcaa ttactgcccc aacaccttct agagctgatt ttacaccatt 14941 tccaaatcct tcaaaagcga ttcctagacc cgtcaataca tctttgatag ccgaaccgac 15001 agatgaaata acagtagcta tgccattgaa tactgcggta atcacaccag ttagcgattg 15061 gataacagcg ctaatggagt taataacccc agaaatacca ccaagaagtc ctgtgaaagc 15121 ccctataacg agagatgccc ctgttgaaac ggctataacg agctgagata atccgcccgc 15181 tactgcgcct acaatctgag agatagctcc agctacaatt ggcaacatag agccaatagc 15241 gtttgcgata ataggtagta aagtggctag actatcagtg acctgttgta agatttgcac 15301 aacaacatcg ccaacggttc ttaaaatttg actaatgcca tcagcttgag ttcctgccaa 15361 ggcaaaagct gctcctacca ttaaaacagc cgctcctaaa gctagccatg tggtaggcgg 15421 taccatagca atcgcagcac caagtccctt gaatgcaatc gctagcccag tgcctatacc 15481 ttgcgcaact gttgatattg cggttcctag agaactaatg ataggggggg attccagaca 15541 aagcagtttt aataccaact ccgatacctt ttgcagctgt tgatatggct gtaccagcag 15601 acttaacgat attacccaag ccgctgaaga tttggctaat aatgccaccg cttcttctag 15661 cgccgttaga ggctttgtct gttccttctt tggctttgtt tccaaagaga ccaaatttgc 15721 tgccaatttt atccaaaaaa gaaccaatga cgctttgtcc cgttaatttt tcgaataact 15781 taaaacctcc agctactgcg gcgaaggtag ctatccaact tcttagtctg ccagggtcca 15841 tctttcctaa aacatcggaa acagctttag cgaagttaga gacgtgttta acaatccctc 15901 caactgttgc tccaaaagtc ttccaattcc ctccgctcat ggcgctagcg acatttttta 15961 aagctcccca aacgctctgc aaagctcctg aaaaagcact aattgctcca gtttgtttga 16021 aaccgtccca aaattcttta acctttgaag tgacagatga aaccgccgat gaaatattag 16081 atacaatttt atcgatatta attccttcaa ggaatttccc aagattacta gcaaacttag 16141 aaaaatcaac tttatcgagt tgtttaccga ttgcttcgat cgctctaatt ccaaattggt 16201 tcactttttc aaacgctggt tgcaatttgt tggataagcc ttctcgcata ccgtcgatgg 16261 cttggtcaac agttttgaac tcagttgcca tcttttggaa actcttatca ttgcctgctt 16321 tttttaccgc ttccaaaaaa tcgctggttt taaccctacc cgcctggata tcggcgacga 16381 gttcatcaag atttttaccc atagatttag cgactttagc catccctgca ggcgtctgtt 16441 ccaacattat cctaaagtct tgccatgcaa ctgttggtct tccaacagct tgtgtcattt 16501 gctgactaat tgatttcata gcctgcttcg gattttcagc agatgcagct aaaccgccaa 16561 aagcttttac gagctttccg gtatctttca cgccaactgc tgctaactgt gcatacgtgc 16621 tagccatatc tgatgccgag tagattgttt tagttgcata gtcttgcatc gccgttttaa 16681 ctgccaaaat ttgttttttt ccaaacccaa tgtccgctaa attagcgtca aaagttttcc 16741 acgctttcgc tgaactattc atctcgccaa gcatagagcc aaggcctgat gacactgtcc 16801 ttgtcattgc cgagatagct tgtccagcta aattcgctcc taacatggat ttaaacatgg 16861 aactagcttt ttgagacacc gatgaaaaac cggttgaacg cttttccaag ccttcgattg 16921 aacggattgc cgattgtaat gttttgccaa aggttttatc aacagctgtc aaaaccgctt 16981 caacagaata agattctccc atttaacctc ctttccttaa aggttagctt tgagaagtaa 17041 atccatacct ttcttgtcgt aaccttcatc aatttcttga gtgatttttc ggatttcttc 17101 ctcataatca aaaaagtcct tgaatttttt ataaacaggg acttcttttt tatttttctt 17161 gccaccaaca agttttgttg ccgtaacttg gtaatttatc caagcttgtt tgtgagcttt 17221 atgtgattca tcaacagccg ctagtgcttt gcctgtcatt aataaatcat attcatacaa 17281 agttaatcgc ccgatttcat tgatgtcagt catgccgaga tatctaatac aattaagcac 17341 aatcatctca aagctttctt gagaagaata atgttttaag cctctgcttc catttccgcc 17401 atgtttttgt ccagtttggc gataaataac tttgaagcgt ttgactgacg taactcgtct 17461 agaacatcat tgaaaagttt ttcgatatct tcgacctcat caatgtagtc ataaatgtcg 17521 ttcaagcttg gacgaggtga ttctgtaatg gttccaacat gaatgatttc ggcaagtgtc 17581 acaacattac gttcaaacaa aaacggaacc gttgattgta aaccagtacc aaatttcatc 17641 ccctcacgtt ctgtaacatg agctttatcc atttcagcaa caaatcgtgt gccaaatttt 17701 acgttatgag tttttccttt aatttccaat tgcattattc tttctccttc aacaataaaa 17761 ggttggatac taaatccaac ctaaccgtta catttcaaag ctgttttctt ttttggtttc 17821 gctggttgta tctttaaatg cgtactgtac agcttttttt tggtcatttg ttaatgtagc 17881 gagccctttt ttaccaacac cattgatggc aaactccatt tcaattacaa tattttcttc 17941 tgcgtttttc ttagcgctga agcttgaaat gtaaccttgg taataagtcg ctaggtattt 18001 attttctcct ccgtttgtcc cattcttaat atcccaaact tttgcaatcc cattttcgtc 18061 gttttttttg cttgcttctt ctgaatcaat atcccaaatt tctacaagct caccatcctc 18121 catggctttt tctagtttag ctgctagtgt gtcaccttta gctaaaatag atgttgcttt 18181 aaagtcgtat tctaaagccc ccacggactg gataatacca tctttagttt tttgtccatc 18241 tacgtcacgg cttttaccaa cttcgtgttc tgtttgaaaa gctagtttag ttgctacctc 18301 actagatgct tcttttaaca aacgaaataa caagattgaa tgaattcctt gttttgcttc 18361 taattgtttt gtttgttctt gtgcttctga cat //