Pre_GI: BLASTP Hits

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Query: NC_018939:547793:565083 Helicobacter pylori 26695 chromosome, complete genome

Start: 565083, End: 565754, Length: 672

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014560:518582:519383519383520225843Helicobacter pylori SJM180 chromosome, complete genomeCAG pathogenicity island protein 122e-128457
NC_017362:506950:524097524097524939843Helicobacter pylori Lithuania75 chromosome, complete genomeCAG pathogenicity island protein 123e-128457
NC_000915:547783:565073565073565915843Helicobacter pylori 26695, complete genomecag pathogenicity island protein (cag12)3e-128457
NC_011498:553525:570733570733571575843Helicobacter pylori P12, complete genomecag pathogenicity island protein T1e-127455
NC_014555:502151:518718518718519560843Helicobacter pylori PeCan4 chromosome, complete genomeCAG pathogenicity island protein 123e-127454
NC_017360:1052473:105357710535771054419843Helicobacter pylori 35A chromosome, complete genomeCAG pathogenicity island protein 123e-127454
NC_017365:848500:849477849477850319843Helicobacter pylori F30, complete genomecag pathogenicity island protein3e-127454
NC_017366:535188:552395552395553237843Helicobacter pylori F32, complete genomecag pathogenicity island protein3e-127454
NC_017368:852490:853291853291854133843Helicobacter pylori F16, complete genomecag pathogenicity island protein3e-127454
NC_011333:514464:531553531553532395843Helicobacter pylori G27 chromosome, complete genomecag pathogenicity island protein T2e-127454
NC_014256:683384:684180684180685022843Helicobacter pylori B8 chromosome, complete genomecag pathogenicity island protein T2e-127454
NC_008086:513407:531228531228532070843Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein T1e-127454
NC_017063:800156:817677817677818519843Helicobacter pylori ELS37 chromosome, complete genomeCAG pathogenicity island protein T3e-127453
NC_017354:848500:849386849386850228843Helicobacter pylori 52 chromosome, complete genomecag pathogenicity island protein T9e-127452
NC_017376:538000:556253556253557095843Helicobacter pylori SNT49 chromosome, complete genomeCAG pathogenicity island protein T9e-127452
NC_017355:493237:510109510109510951843Helicobacter pylori v225d chromosome, complete genomecag pathogenicity island protein8e-127452
NC_017358:563336:579434579434580276843Helicobacter pylori Cuz20 chromosome, complete genomeCAG pathogenicity island protein 128e-127452
NC_017359:813500:814480814480815322843Helicobacter pylori Sat464 chromosome, complete genomeCAG pathogenicity island protein 128e-127452
NC_017367:562918:579510579510580352843Helicobacter pylori F57, complete genomecag pathogenicity island protein8e-127452
NC_017378:502806:519494519494520336843Helicobacter pylori Puno120 chromosome, complete genomeCAG pathogenicity island protein T8e-127452
NC_017379:505350:522294522294523136843Helicobacter pylori Puno135 chromosome, complete genomeCAG pathogenicity island protein T8e-127452
NC_000921:511642:528613528613529455843Helicobacter pylori J99, complete genomecag island protein2e-126451
NC_017375:872478:873279873279874121843Helicobacter pylori 83 chromosome, complete genomeCAG pathogenicity island protein 122e-126451
NC_017372:855384:856185856185857027843Helicobacter pylori India7 chromosome, complete genomeCAG pathogenicity island protein 124e-126450
NC_010698:819912:826879826879827721843Helicobacter pylori Shi470, complete genomecag pathogenicity island protein (cag12)4e-126450
NC_017357:495213:514131514131514973843Helicobacter pylori 908 chromosome, complete genomecag pathogenicity island protein4e-126450
NC_017374:498588:513152513152513994843Helicobacter pylori 2017 chromosome, complete genomecag pathogenicity island protein4e-126450
NC_017381:500699:515252515252516094843Helicobacter pylori 2018 chromosome, complete genomecag pathogenicity island protein4e-126450
NC_017371:530673:547993547993548835843Helicobacter pylori Gambia94/24 chromosome, complete genomeCAG pathogenicity island protein T3e-125447