Pre_GI: BLASTP Hits

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Query: NC_018939:454000:464163 Helicobacter pylori 26695 chromosome, complete genome

Start: 464163, End: 464942, Length: 780

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000915:453958:464158464158464937780Helicobacter pylori 26695, complete genomehypothetical protein2e-150531
NC_014555:1526775:153714115371411537920780Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein3e-135480
NC_014256:448710:452304452304453038735Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-116419
NC_015674:1562968:157339315733931574160768Helicobacter bizzozeronii CIII-1, complete genomehypothetical protein4e-45181
NC_017063:834674:838627838627839415789Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein2e-38159
NC_011498:1391788:139483313948331395621789Helicobacter pylori P12, complete genomehypothetical protein2e-38159
NC_014256:485969:526001526001526789789Helicobacter pylori B8 chromosome, complete genomehypothetical protein2e-38159
NC_017366:1055319:105823610582361059024789Helicobacter pylori F32, complete genomeintegrase/recombinase (XERCD family)3e-38158
NC_011333:1040192:104576410457641046528765Helicobacter pylori G27 chromosome, complete genomehypothetical protein7e-33140
NC_017358:220900:227880227880228644765Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein1e-32140
NC_017367:278916:284353284353285117765Helicobacter pylori F57, complete genomehypothetical protein1e-31136
NC_000921:1007519:104368410436841044679996Helicobacter pylori J99, complete genomeINTEGRASE/RECOMBINASE (XERCD FAMILY)3e-1168.9