Pre_GI: BLASTP Hits

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Query: NC_018939:454000:462022 Helicobacter pylori 26695 chromosome, complete genome

Start: 462022, End: 462324, Length: 303

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000915:453958:462016462016462318303Helicobacter pylori 26695, complete genomehypothetical protein9e-53204
NC_017361:1528239:153006215300621530364303Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein7e-45179
NC_014555:1526775:153979015397901540065276Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein1e-44178
NC_011333:1040192:104843210484321048734303Helicobacter pylori G27 chromosome, complete genomehypothetical protein1e-1375.1
NC_017379:1035464:105695610569561057258303Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein1e-1375.1
NC_017358:220900:230561230561230863303Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein1e-1375.1
NC_017367:278916:287034287034287336303Helicobacter pylori F57, complete genomevirB2 type IV secretion protein2e-1374.7