Pre_GI: BLASTP Hits

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Query: NC_018939:454000:459339 Helicobacter pylori 26695 chromosome, complete genome

Start: 459339, End: 461762, Length: 2424

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000915:453958:4593334593334617562424Helicobacter pylori 26695, complete genomeVirB4 homolog01559
NC_017361:1528239:1530624153062415330472424Helicobacter pylori SouthAfrica7 chromosome, complete genomeVirB4-like protein01501
NC_014555:1526775:1540379154037915427482370Helicobacter pylori PeCan4 chromosome, complete genomeVirB4-like protein01459
NC_014256:448710:4557574557574579102154Helicobacter pylori B8 chromosome, complete genomeprotein virB401351
NC_011498:448000:4871074871074895292423Helicobacter pylori P12, complete genome01048
NC_017358:220900:2311372311372336352499Helicobacter pylori Cuz20 chromosome, complete genomeDNA transfer protein1e-167590
NC_017367:278916:2876102876102901082499Helicobacter pylori F57, complete genomeDNA transfer protein3e-167589
NC_017376:57500:9483294832973302499Helicobacter pylori SNT49 chromosome, complete genomeDNA transfer protein4e-167589
NC_010698:870312:9080599080599105572499Helicobacter pylori Shi470, complete genomeDNA transfer protein2e-166587
NC_017361:930280:9679779679779704752499Helicobacter pylori SouthAfrica7 chromosome, complete genomeDNA transfer protein5e-166585
NC_017379:1035464:1054184105418410566822499Helicobacter pylori Puno135 chromosome, complete genomeDNA transfer protein2e-165583
NC_017371:1030148:1034552103455210364771926Helicobacter pylori Gambia94/24 chromosome, complete genomeDNA transfer protein4e-134479
NC_014256:485969:5220375220375246132577Helicobacter pylori B8 chromosome, complete genometype IV secretion system protein VirB42e-129464
NC_011498:1391788:1397130139713013997062577Helicobacter pylori P12, complete genomeVirB4 type IV secretion ATPase2e-129463
NC_017371:1470582:1516315151631515188912577Helicobacter pylori Gambia94/24 chromosome, complete genomeVirB4 type IV secretion ATPase3e-129462
NC_017372:748097:7931967931967957782583Helicobacter pylori India7 chromosome, complete genomeVirB4 type IV secretion ATPase1e-127457
NC_005090:1033746:1054413105441310567012289Wolinella succinogenes DSM 1740, complete genomeVIRB4 HOMOLOG6e-96352
NC_000921:1007519:1015042101504210164691428Helicobacter pylori J99, complete genomeDNA transfer protein2e-92340
NC_017366:1055319:1061646106164610626621017Helicobacter pylori F32, complete genomevirB4 type IV secretion ATPase3e-58227
NC_017366:1055319:1060409106040910615571149Helicobacter pylori F32, complete genomevirB4 protein4e-42173
NC_015674:1562968:157503915750391575908870Helicobacter bizzozeronii CIII-1, complete genomeATPase8e-41169
NC_014256:448710:455488455488455736249Helicobacter pylori B8 chromosome, complete genomeDNA transfer protein4e-35150
NC_007798:758873:7709267709267733372412Neorickettsia sennetsu str. Miyayama, complete genometype IV secretion system protein VirB47e-33142
NC_007354:756500:7787647787647811662403Ehrlichia canis str. Jake, complete genomeCagE, TrbE, VirB family component of typeIV transporter system2e-32141
NC_007799:474931:4813444813444837462403Ehrlichia chaffeensis str. Arkansas, complete genometype IV secretion system protein VirB43e-32140
NC_005295:873500:8983268983269007282403Ehrlichia ruminantium str. Welgevonden, complete genometype IV secretion system protein VirB48e-31136
NC_006832:853500:8778888778888802932406Ehrlichia ruminantium str. Welgevonden, complete genomeVIRB4 protein precursor1e-30135
NC_006831:849500:8734978734978759022406Ehrlichia ruminantium str. Gardel, complete genomeVIRB4 protein precursor1e-30135
NC_015593:1587684:1602558160255816049302373Sphingobium chlorophenolicum L-1 chromosome chromosome 1, completetype IV secretion/conjugal transfer ATPase VirB4 family1e-29132
NC_017028:180219:1951301951301975472418Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completetype IV secretion system ATPase VirB43e-29130
NC_017044:130000:1353941353941378112418Rickettsia parkeri str. Portsmouth chromosome, complete genometype IV secretion system ATPase VirB41e-28129
NC_010793:794494:7995707995708019872418Orientia tsutsugamushi str. Ikeda, complete genometype IV secretion system protein VirB42e-28128
NC_017048:452000:4560924560924585092418Rickettsia prowazekii str. GvV257 chromosome, complete genometype IV secretion system ATPase VirB45e-28127
NC_017049:109000:1122221122221146392418Rickettsia prowazekii str. Chernikova chromosome, complete genometype IV secretion system ATPase VirB45e-28127
NC_017051:109000:1122251122251146422418Rickettsia prowazekii str. Dachau chromosome, complete genometype IV secretion system ATPase VirB45e-28127
NC_017056:110500:1140311140311164482418Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genometype IV secretion system ATPase VirB45e-28127
NC_017057:110000:1141481141481165652418Rickettsia prowazekii str. RpGvF24 chromosome, complete genometype IV secretion system ATPase VirB45e-28127
NC_006142:33268:4454644546469632418Rickettsia typhi str. Wilmington, complete genomeVirB4 protein precursor4e-28127
NC_017062:33268:4451344513469302418Rickettsia typhi str. B9991CWPP chromosome, complete genometype IV secretion system ATPase VirB44e-28127
NC_017066:33268:4454644546469632418Rickettsia typhi str. TH1527 chromosome, complete genometype IV secretion system ATPase VirB44e-28127
NC_009488:1871912:1877046187704618794632418Orientia tsutsugamushi str. Boryong, complete genometype IV secretion system ATPase VirB44e-28127
NC_000963:110500:1140231140231164402418Rickettsia prowazekii str. Madrid E, complete genomeVIRB4 PROTEIN PRECURSOR (virB4)3e-28127
NC_017050:110500:1140211140211164382418Rickettsia prowazekii str. Katsinyian chromosome, complete genometype IV secretion system ATPase VirB43e-28127
NC_016929:109500:1131401131401155572418Rickettsia canadensis str. CA410 chromosome, complete genometype IV secretion system ATPase VirB41e-26122
NC_009879:107890:1122791122791146962418Rickettsia canadensis str. McKiel, complete genomeType IV secretion/conjugal transfer ATPase, VirB4 family protein1e-26122
NC_000921:1007519:101645710164571016879423Helicobacter pylori J99, complete genomeDNA transfer protein1e-21105
NC_014801:1:2335823358261262769Campylobacter jejuni subsp. jejuni ICDCCJ07001 plasmid pTet,type IV secretion system protein VirB41e-21105
NC_011206:1293880:1291361129136112938832523Acidithiobacillus ferrooxidans ATCC 53993, complete genomeCagE TrbE VirB component of type IV transporter system4e-1687.4
NC_013416:939668:9496729496729512131542Aggregatibacter actinomycetemcomitans D11S-1, complete genomeATPase7e-1583.2
NC_016513:2103958:2125571212557121283422772Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completeATPase1e-1482.4
NC_006371:1743982:1748726174872617511222397Photobacterium profundum SS9 chromosome 2, complete sequencehypothetical TrbE protein2e-1482
NC_011985:3869998:3871859387185938742462388Agrobacterium radiobacter K84 chromosome 1, complete genometype IV secretion protein AvhB42e-1481.6
NC_015221:12389:1238912389149232535Nitrosomonas sp. AL212 plasmid pNAL21202, complete sequencetype IV secretion/conjugal transfer ATPase, VirB4 family9e-1479.7
NC_013422:1755875:1755875175587517583342460Halothiobacillus neapolitanus c2, complete genomeCagE, TrbE, VirB component of type IV transporter system, conserved region3e-1377.8
NC_011071:2733438:2745103274510327475502448Stenotrophomonas maltophilia R551-3, complete genometype IV secretion/conjugal transfer ATPase, VirB4 family6e-1376.6
NC_015947:2752450:2763456276345627659032448Burkholderia sp. JV3 chromosome, complete genometype IV secretion/conjugal transfer ATPase, VirB4 family8e-1376.6
NC_010170:3908500:3916385391638539188292445Bordetella petrii, complete genometype IV secretion system protein VirB49e-1376.3
NC_013722:2150882:2156995215699521594662472Xanthomonas albilineans, complete genomeprobable type iv secretion system protein virb48e-1376.3
NC_010943:3034366:3043399304339930458462448Stenotrophomonas maltophilia K279a, complete genomeputative type IV secretion conjugal transfer protein1e-1275.9
NC_017271:2935643:2964110296411029665512442Xanthomonas campestris pv. raphani 756C chromosome, completeVirB4 protein3e-1274.7
NC_015675:6276357:6333713633371363360822370Mesorhizobium opportunistum WSM2075 chromosome, complete genometype IV secretion/conjugal transfer ATPase, VirB4 family3e-1171.2
NC_014923:5765660:5779042577904257814112370Mesorhizobium ciceri biovar biserrulae WSM1271 chromosome, completetype IV secretion/conjugal transfer ATPase, VirB4 family3e-1171.2
NC_019973:5694620:5708002570800257103712370Mesorhizobium australicum WSM2073, complete genometype IV secretion/conjugal transfer ATPase, VirB4 family3e-1171.2
NC_003919:3060484:3079127307912730815802454Xanthomonas axonopodis pv. citri str. 306, complete genomeVirB4 protein5e-1170.5
NC_007086:1936505:1964408196440819668612454Xanthomonas campestris pv. campestris str. 8004, complete genomeVirB4 protein8e-1169.7
NC_003902:2933121:2943358294335829458112454Xanthomonas campestris pv. campestris str. ATCC 33913, completeVirB4 protein8e-1169.7
NC_010688:1908012:1937139193713919395922454Xanthomonas campestris pv. campestris, complete genometype IV secretion system energizing component VirB41e-1069.3
NC_004547:1873390:1874142187414218768892748Erwinia carotovora subsp. atroseptica SCRI1043, complete genomeputative conjugal transfer protein6e-1067
NC_017047:2079368:2079368207936820821152748Rahnella aquatilis HX2 chromosome, complete genomeputative conjugal transfer protein4e-0964.3
NC_006833:976010:9866539866539890072355Wolbachia endosymbiont strain TRS of Brugia malayi, completeType IV secretory pathway, VirB4 components4e-0963.9
NC_010688:1908012:1944292194429219458151524Xanthomonas campestris pv. campestris, complete genomeVirB4 protein6e-0963.5
NC_011283:1811000:1847938184793818506852748Klebsiella pneumoniae 342 chromosome, complete genometype IV secretion/conjugal transfer ATPase9e-0963.2
NC_014500:3097362:3147941314794131507212781Dickeya dadantii 3937 chromosome, complete genomeATPase provides energy for both assembly of type IV secretion complex and secretion of T-DNA complex (VirB4)2e-0862
NC_012912:1701231:1705041170504117077882748Dickeya zeae Ech1591, complete genomeCagE TrbE VirB component of type IV transporter system2e-0862
NC_016818:1795576:1829965182996518327122748Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completetype IV secretory pathway, VirB4 component2e-0862
NC_014914:127873:1317401317401341452406Taylorella equigenitalis MCE9 chromosome, complete genomeVirB4 ATPase like protein4e-0860.8