Pre_GI: BLASTP Hits

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Query: NC_018939:1583653:1583990 Helicobacter pylori 26695 chromosome, complete genome

Start: 1583990, End: 1584316, Length: 327

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000915:1583967:158396715839671584293327Helicobacter pylori 26695, complete genomehypothetical protein1e-57221
NC_017378:1489818:148981814898181490144327Helicobacter pylori Puno120 chromosome, complete genomeFrpB-like protein3e-54209
NC_017378:1489818:1490298149029814928892592Helicobacter pylori Puno120 chromosome, complete genomeiron-regulated outer membrane protein5e-0649.7
NC_017367:1505780:1505780150578015083712592Helicobacter pylori F57, complete genomeputative IRON-regulated outer membrane protein6e-0649.7
NC_017371:1601452:1601452160145216040912640Helicobacter pylori Gambia94/24 chromosome, complete genomeiron-regulated outer membrane protein8e-0649.3
NC_018939:1583653:1584470158447015871032634Helicobacter pylori 26695 chromosome, complete genomeiron-regulated outer membrane protein8e-0649.3
NC_000915:1583967:1584447158444715870802634Helicobacter pylori 26695, complete genomeiron-regulated outer membrane protein (frpB)8e-0649.3