Pre_GI: BLASTP Hits

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Query: NC_018939:1044000:1063446 Helicobacter pylori 26695 chromosome, complete genome

Start: 1063446, End: 1063730, Length: 285

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000915:1044000:106342810634281063712285Helicobacter pylori 26695, complete genomehypothetical protein2e-47187
NC_014256:448710:470450470450470734285Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-46184
NC_011498:448000:471523471523471807285Helicobacter pylori P12, complete genomehypothetical protein1e-46184
NC_017371:1030148:104981510498151050099285Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein3e-46183
NC_017376:57500:794937949379777285Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein8e-46182
NC_011333:1040192:106647510664751066759285Helicobacter pylori G27 chromosome, complete genomehypothetical protein4e-46182
NC_017361:930280:952709952709952993285Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein4e-46182
NC_017375:1498000:150371715037171504001285Helicobacter pylori 83 chromosome, complete genomehypothetical protein9e-46181
NC_017379:1035464:103890310389031039187285Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein1e-45181
NC_014555:1526775:155830015583001558584285Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein3e-45180
NC_017361:1528239:154890015489001549169270Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein2e-41167
NC_017367:278916:305126305126305395270Helicobacter pylori F57, complete genomehypothetical protein2e-41167
NC_010698:870312:892794892794893063270Helicobacter pylori Shi470, complete genomehypothetical protein4e-41166
NC_017358:220900:248624248624248893270Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein1e-40164
NC_017372:748097:768750768750769127378Helicobacter pylori India7 chromosome, complete genomehypothetical protein3e-0753.9
NC_017366:1055319:107133610713361071695360Helicobacter pylori F32, complete genomehypothetical protein3e-0753.9
NC_017378:1518529:153654715365471536939393Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein7e-0752.8
NC_014560:1366747:139495513949551395347393Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein1e-0652
NC_017375:77142:906059060591042438Helicobacter pylori 83 chromosome, complete genomehypothetical protein2e-0651.2
NC_017371:1470582:149089314908931491270378Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein3e-0650.8
NC_017063:834674:867654867654868031378Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein3e-0650.8
NC_014256:485969:506360506360506737378Helicobacter pylori B8 chromosome, complete genomehypothetical protein3e-0650.8