Pre_GI: BLASTP Hits

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Query: NC_018939:1044000:1062203 Helicobacter pylori 26695 chromosome, complete genome

Start: 1062203, End: 1062439, Length: 237

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014560:1366747:1382017138201713905218505Helicobacter pylori SJM180 chromosome, complete genomeadenine specific DNA methyltransferase8e-22102
NC_017362:1512959:1542212154221215508128601Helicobacter pylori Lithuania75 chromosome, complete genomeadenine specific DNA methyltransferase5e-2096.3
NC_017372:748097:7732547732547818548601Helicobacter pylori India7 chromosome, complete genomeadenine specific DNA methyltransferase2e-2097.8
NC_011333:1040192:1067764106776410761908427Helicobacter pylori G27 chromosome, complete genomeadenine specific DNA methyltransferase6e-35145
NC_017063:834674:8539908539908625368547Helicobacter pylori ELS37 chromosome, complete genomeadenine specific DNA methyltransferase3e-21100
NC_011498:448000:4620964620964705228427Helicobacter pylori P12, complete genomeDNA methylase2e-32137
NC_017376:57500:7006270062784888427Helicobacter pylori SNT49 chromosome, complete genomeDNA methylase5e-30129
NC_017375:1498000:1504994150499415134118418Helicobacter pylori 83 chromosome, complete genomeDNA methylase2e-31134
NC_014256:448710:4717384717384792947557Helicobacter pylori B8 chromosome, complete genomehypothetical protein2e-34144
NC_000915:1044000:106223610622361062421186Helicobacter pylori 26695, complete genomehypothetical protein4e-28123
NC_017361:930280:9432999432999517078409Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein9e-32135
NC_017367:278916:3063993063993148558457Helicobacter pylori F57, complete genomehypothetical protein1e-29128
NC_017378:1518529:1526278152627815321095832Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein1e-2098.6
NC_000921:1007519:103202510320251032477453Helicobacter pylori J99, complete genomehypothetical protein4e-1993.6
NC_017361:1528239:1550176155017615585848409Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein9e-32135
NC_010698:870312:8833758833758917868412Helicobacter pylori Shi470, complete genomehypothetical protein1e-29128
NC_017366:1055319:1062619106261910661703552Helicobacter pylori F32, complete genomehypothetical protein2e-1994.4