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Query: NC_018939:1044000:1050829 Helicobacter pylori 26695 chromosome, complete genome

Start: 1050829, End: 1051062, Length: 234

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000915:1044000:105081210508121051045234Helicobacter pylori 26695, complete genomehypothetical protein2e-36150
NC_000921:1007519:1045778104577810478112034Helicobacter pylori J99, complete genomehypothetical protein4e-23106
NC_017362:1512959:1517467151746715195002034Helicobacter pylori Lithuania75 chromosome, complete genomerelaxase5e-23106
NC_014256:485969:488306488306488938633Helicobacter pylori B8 chromosome, complete genomehypothetical protein5e-22103
NC_017371:1470582:1474666147466614766962031Helicobacter pylori Gambia94/24 chromosome, complete genomerelaxase1e-2098.6
NC_017372:748097:7529897529897550192031Helicobacter pylori India7 chromosome, complete genomehypothetical protein4e-1889.7
NC_017379:996500:1015676101567610177152040Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein6e-1889.4
NC_000915:453958:453958453958454323366Helicobacter pylori 26695, complete genomehypothetical protein1e-1065.1