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Query: NC_017516:2220000:2224608 Neisseria meningitidis H44/76 chromosome, complete genome

Start: 2224608, End: 2225354, Length: 747

Host Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008767:2160000:216464921646492165416768Neisseria meningitidis FAM18, complete genomehypothetical protein1e-140499
NC_017512:2209000:221105722110572211842786Neisseria meningitidis WUE 2594, complete genomehypothetical protein1e-138492
NC_017511:1812000:181634318163431817089747Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomehypothetical protein4e-135480
NC_011035:1908000:191250019125001913246747Neisseria gonorrhoeae NCCP11945 chromosome, complete genomehypothetical protein4e-135480
NC_002946:1902642:191936219193621920108747Neisseria gonorrhoeae FA 1090, complete genomehypothetical protein3e-134477
NC_012913:1041969:105696610569661057679714Aggregatibacter aphrophilus NJ8700, complete genomehypothetical protein7e-30130