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Query: NC_017379:996500:998936 Helicobacter pylori Puno135 chromosome, complete genome

Start: 998936, End: 999049, Length: 114

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017378:986611:989024989024989329306Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein3e-1477
NC_017355:997089:100027510002751000415141Helicobacter pylori v225d chromosome, complete genomehypothetical protein6e-1372.8
NC_017367:278916:2812252812252822801056Helicobacter pylori F57, complete genomehypothetical protein1e-0652
NC_018939:1044000:104457010445701044872303Helicobacter pylori 26695 chromosome, complete genomehypothetical protein6e-0649.7
NC_000915:1044000:104455210445521044854303Helicobacter pylori 26695, complete genomeconserved hypothetical secreted protein6e-0649.7
NC_012973:967380:967380967380967676297Helicobacter pylori B38 chromosome, complete genomemetallopeptidase9e-0648.9