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Query: NC_017379:996500:1012722 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1012722, End: 1013408, Length: 687

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017378:986611:100282010028201003506687Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein3e-120431
NC_017362:992293:100447810044781005095618Helicobacter pylori Lithuania75 chromosome, complete genomeprotein phosphatase 2 C-like protein (ptc1)2e-103374
NC_017355:997089:101454010145401015055516Helicobacter pylori v225d chromosome, complete genomeserine/threonine phosphatase 2C-like protein5e-87320
NC_012973:967380:982194982194982535342Helicobacter pylori B38 chromosome, complete genome2e-50199
NC_012973:967380:982561982561982812252Helicobacter pylori B38 chromosome, complete genome8e-40163
NC_010002:4572573:459391545939154594631717Delftia acidovorans SPH-1, complete genomehypothetical protein5e-1374.7
NC_010170:4463000:450176745017674502483717Bordetella petrii, complete genomehypothetical protein5e-1374.7
NC_013410:2691437:270616127061612706886726Fibrobacter succinogenes subsp. succinogenes S85 chromosome,hypothetical protein8e-1167.4
NC_017068:1450049:144935214493521450062711Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein2e-0756.2